CELSR3 homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

CELSR3

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-09-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

GLP-1 receptor (sequence similarity: 4%) PDB: 5NX2
Align

TEMPLATES

5NX2 (GLP-1 receptor)
6X1A (GLP-1 receptor)
6PB1 (CRF2 receptor)
7JHJ (BILF1)
7D77 (ADGRG3)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 81.7 7.8 10.4
Side-chains 21.3 30.2 48.5

Number of backbone templates: 5
Number of rotamer templates: 16

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 2529 R - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 2530 E - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 2531 R - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 2532 L - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 2533 E - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2534 G 1.34x34 GLP-1 receptor 5NX2 - -
TM1 2535 D 1.35x35 GLP-1 receptor 5NX2 - -
TM1 2536 L 1.36x36 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2537 E 1.37x37 GLP-1 receptor 5NX2 GIP receptor 7DTY
TM1 2538 L 1.38x38 GLP-1 receptor 5NX2 - -
TM1 2539 L 1.39x39 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2540 A 1.40x40 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM1 2541 V 1.41x41 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 2542 F 1.42x42 GLP-1 receptor 5NX2 - -
TM1 2543 T 1.43x43 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM1 2544 H 1.44x44 GLP-1 receptor 5NX2 - -
TM1 2545 V 1.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2546 V 1.46x46 GLP-1 receptor 5NX2 - -
TM1 2547 V 1.47x47 GLP-1 receptor 5NX2 - -
TM1 2548 A 1.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2549 V 1.49x49 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 2550 S 1.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2551 V 1.51x51 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 2552 A 1.52x52 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 2553 A 1.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2554 L 1.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2555 V 1.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2556 L 1.56x56 GLP-1 receptor 5NX2 GIP receptor 7DTY
TM1 2557 T 1.57x57 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 2558 A 1.58x58 GLP-1 receptor 5NX2 - -
TM1 2559 A 1.59x59 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2560 I 1.60x60 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2561 L 1.61x61 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2562 L 1.62x62 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2563 S 1.63x63 GLP-1 receptor 5NX2 - -
TM1 2564 L 1.64x64 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
ICL1 2565 R 12.48x48 - - - -
ICL1 2566 S 12.49x49 CRF2 receptor 6PB1 CRF2 receptor 6PB1
ICL1 2567 L 12.50x50 CRF2 receptor 6PB1 GLP-1 receptor 5NX2
ICL1 2568 K 12.51x51 - - - -
TM2 2569 S 2.44x44 GLP-1 receptor 5NX2 - -
TM2 2570 N 2.45x45 GLP-1 receptor 5NX2 - -
TM2 2571 V 2.46x46 GLP-1 receptor 5NX2 - -
TM2 2572 R 2.47x47 GLP-1 receptor 5NX2 - -
TM2 2573 G 2.48x48 GLP-1 receptor 5NX2 - -
TM2 2574 I 2.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 2575 H 2.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 2576 A 2.51x51 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM2 2577 N 2.52x52 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 2578 V 2.53x53 GLP-1 receptor 5NX2 - -
TM2 2579 A 2.54x54 GLP-1 receptor 5NX2 - -
TM2 2580 A 2.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 2581 A 2.56x56 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM2 2582 L 2.57x57 GLP-1 receptor 5NX2 ADGRG3 7D77
TM2 2583 G 2.58x58 GLP-1 receptor 5NX2 - -
TM2 2584 V 2.59x59 GLP-1 receptor 5NX2 - -
TM2 2585 A 2.60x60 GLP-1 receptor 5NX2 - -
TM2 2586 E 2.61x61 GLP-1 receptor 5NX2 - -
TM2 2587 L 2.62x62 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 2588 L 2.63x63 GLP-1 receptor 5NX2 - -
TM2 2589 F 2.64x64 GLP-1 receptor 5NX2 ADGRG3 7D77
TM2 2590 L 2.65x65 GLP-1 receptor 5NX2 ADGRG3 7D77
TM2 2591 L 2.66x66 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM2 2592 G 2.67x67 GLP-1 receptor 5NX2 - -
TM2 2593 I 2.68x68 GLP-1 receptor 5NX2 - -
TM2 2594 H 2.69x69 GLP-1 receptor 5NX2 - -
TM2 2595 R 2.70x70 GLP-1 receptor 5NX2 - -
ECL1 2596 T - - - - -
ECL1 2597 H - - - - -
ECL1 2598 N - - - - -
ECL1 2599 Q - - - - -
TM3 2600 L 3.27x27 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 2601 V 3.28x28 GLP-1 receptor 5NX2 - -
TM3 2602 C 3.29x29 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 2603 T 3.30x30 GLP-1 receptor 5NX2 - -
TM3 2604 A 3.31x31 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 2605 V 3.32x32 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 2606 A 3.33x33 GLP-1 receptor 5NX2 glucagon receptor 5YQZ
TM3 2607 I 3.34x34 GLP-1 receptor 5NX2 GIP receptor 7DTY
TM3 2608 L 3.35x35 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM3 2609 L 3.36x36 GLP-1 receptor 5NX2 GLP-2 receptor 7D68
TM3 2610 H 3.37x37 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 2611 Y 3.38x38 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 2612 F 3.39x39 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 2613 F 3.40x40 GLP-1 receptor 5NX2 - -
TM3 2614 L 3.41x41 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 2615 S 3.42x42 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM3 2616 T 3.43x43 GLP-1 receptor 5NX2 - -
TM3 2617 F 3.44x44 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 2618 A 3.45x45 GLP-1 receptor 5NX2 - -
TM3 2619 W 3.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 2620 L 3.47x47 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 2621 F 3.48x48 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 2622 V 3.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 2623 Q 3.50x50 GLP-1 receptor 5NX2 - -
TM3 2624 G 3.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 2625 L 3.52x52 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM3 2626 H 3.53x53 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 2627 L 3.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 2628 Y 3.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 2629 R 3.56x56 GLP-1 receptor 5NX2 - -
TM3 2630 M 3.57x57 GLP-1 receptor 5NX2 - -
TM3 2631 Q 3.58x58 GLP-1 receptor 5NX2 - -
TM3 2632 V 3.59x59 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 2633 E 3.60x60 GLP-1 receptor 5NX2 - -
ICL2 2634 P - - - - -
ICL2 2635 R - CRF2 receptor 6PB1 - -
ICL2 2636 N - CRF2 receptor 6PB1 - -
ICL2 2637 V - CRF2 receptor 6PB1 - -
ICL2 2638 D - CRF2 receptor 6PB1 - -
ICL2 2639 R - CRF2 receptor 6PB1 CRF2 receptor 6PB1
ICL2 2640 G - - - - -
TM4 2641 A 4.41x42 GLP-1 receptor 5NX2 GHRH receptor 7CZ5
TM4 2642 M 4.42x43 GLP-1 receptor 5NX2 - -
TM4 2643 R 4.43x44 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 2644 F 4.44x45 GLP-1 receptor 5NX2 - -
TM4 2645 Y 4.45x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 2646 H 4.46x47 GLP-1 receptor 5NX2 - -
TM4 2647 A 4.47x48 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 2648 L 4.48x49 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM4 2649 G 4.49x491 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 2650 W 4.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 2651 G 4.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 2652 V 4.52x52 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 2653 P 4.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 2654 A 4.54x54 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 2655 V 4.55x55 GLP-1 receptor 5NX2 CT receptor 6NIY
TM4 2656 L 4.56x56 GLP-1 receptor 5NX2 BILF1 7JHJ
TM4 2657 L 4.57x57 GLP-1 receptor 5NX2 - -
TM4 2658 G 4.58x58 GLP-1 receptor 5NX2 GHRH receptor 7CZ5
TM4 2659 L 4.59x59 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 2660 A 4.60x60 GLP-1 receptor 5NX2 - -
TM4 2661 V 4.61x61 GLP-1 receptor 5NX2 GIP receptor 7DTY
TM4 2662 G 4.62x62 GLP-1 receptor 5NX2 - -
TM4 2663 L 4.63x63 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM4 2664 D 4.64x64 GLP-1 receptor 5NX2 - -
ECL2 2665 P - - - - -
ECL2 2666 E - - - - -
ECL2 2667 G - - - - -
ECL2 2668 Y - - - - -
ECL2 2669 G - - - - -
ECL2 2670 N - - - - -
ECL2 2671 P - - - - -
ECL2 2672 D - - - - -
ECL2 2673 F - - - - -
ECL2 2674 C 45.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 2675 W 45.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 2676 I 45.52x52 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
ECL2 2677 S - GLP-1 receptor 5NX2 - -
ECL2 2678 V - GLP-1 receptor 5NX2 - -
ECL2 2679 H - GLP-1 receptor 5NX2 - -
TM5 2680 E 5.33x33 GLP-1 receptor 5NX2 - -
TM5 2681 P 5.34x34 GLP-1 receptor 5NX2 - -
TM5 2682 L 5.35x35 GLP-1 receptor 5NX2 - -
TM5 2683 I 5.36x36 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 2684 W 5.37x37 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 2685 S 5.38x38 BILF1 7JHJ - -
TM5 2686 F 5.39x39 BILF1 7JHJ - -
TM5 2687 A 5.40x40 GLP-1 receptor 5NX2 BILF1 7JHJ
TM5 2688 G 5.41x41 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM5 2689 P 5.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 2690 V 5.43x43 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 2691 V 5.44x44 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM5 2692 L 5.45x45 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM5 2693 V 5.46x46 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM5 2694 I 5.47x47 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 2695 V 5.48x48 GLP-1 receptor 5NX2 CT receptor 6NIY
TM5 2696 M 5.49x49 GLP-1 receptor 5NX2 - -
TM5 2697 N 5.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 2698 G 5.51x51 GLP-1 receptor 5NX2 - -
TM5 2699 T 5.52x52 GLP-1 receptor 5NX2 - -
TM5 2700 M 5.53x53 GLP-1 receptor 5NX2 - -
TM5 2701 F 5.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 2702 L 5.55x55 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM5 2703 L 5.56x56 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 2704 A 5.57x57 GLP-1 receptor 5NX2 - -
TM5 2705 A 5.58x58 GLP-1 receptor 5NX2 - -
TM5 2706 R 5.59x59 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM5 2707 T 5.60x60 GLP-1 receptor 5NX2 - -
TM5 2708 S 5.61x61 GLP-1 receptor 5NX2 - -
TM5 2709 C 5.62x62 GLP-1 receptor 5NX2 - -
TM5 2710 S 5.63x63 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 2711 T 5.64x64 GLP-1 receptor 5NX2 - -
TM5 2712 G 5.65x65 GLP-1 receptor 5NX2 - -
TM5 2713 Q 5.66x66 CRF2 receptor 6PB1 PAC1 receptor 6P9Y
TM5 2714 R 5.67x67 CRF2 receptor 6PB1 - -
ICL3 2715 E - - - - -
ICL3 2716 A - - - - -
ICL3 2717 K - - - - -
ICL3 2718 K - - - - -
TM6 2719 T 6.34x34 GLP-1 receptor 5NX2 - -
TM6 2720 S 6.35x35 GLP-1 receptor 5NX2 - -
TM6 2721 A 6.36x36 GLP-1 receptor 5NX2 - -
TM6 2722 L 6.37x37 GLP-1 receptor 5NX2 - -
TM6 2723 T 6.38x38 GLP-1 receptor 5NX2 - -
TM6 2724 L 6.39x39 GLP-1 receptor 5NX2 PTH1 receptor 6NBI
TM6 2725 R 6.40x40 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM6 2726 S 6.41x41 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 2727 S 6.42x42 GLP-1 receptor 5NX2 - -
TM6 2728 F 6.43x43 GLP-1 receptor 5NX2 - -
TM6 2729 L 6.44x44 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM6 2730 L 6.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 2731 L 6.46x46 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM6 2732 L 6.47x47 GLP-1 receptor 5NX2 BILF1 7JHJ
TM6 2733 L 6.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 2734 V 6.49x49 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 2735 S 6.50x50 GLP-1 receptor 5NX2 - -
TM6 2736 A 6.51x51 GLP-1 receptor 5NX2 - -
TM6 2737 S 6.52x52 GLP-1 receptor 5NX2 BILF1 7JHJ
TM6 2738 W 6.53x53 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 2739 L 6.54x54 GLP-1 receptor 5NX2 - -
TM6 2740 F 6.55x55 GLP-1 receptor 5NX2 - -
TM6 2741 G 6.56x56 GLP-1 receptor 5NX2 - -
TM6 2742 L 6.57x57 GLP-1 receptor 5NX2 - -
TM6 2743 L 6.58x58 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
ECL3 2744 A - - - - -
ECL3 2745 V - GLP-1 receptor 6X1A - -
ECL3 2746 N - GLP-1 receptor 6X1A - -
ECL3 2747 H - GLP-1 receptor 6X1A - -
ECL3 2748 S - - - - -
TM7 2749 I 7.35x34 GLP-1 receptor 5NX2 - -
TM7 2750 L 7.36x35 GLP-1 receptor 5NX2 GLP-2 receptor 7D68
TM7 2751 A 7.37x36 GLP-1 receptor 5NX2 GIP receptor 7DTY
TM7 2752 F 7.38x37 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 2753 H 7.39x38 GLP-1 receptor 5NX2 - -
TM7 2754 Y 7.40x39 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 2755 L 7.41x40 GLP-1 receptor 5NX2 GHRH receptor 7CZ5
TM7 2756 H 7.42x41 GLP-1 receptor 5NX2 - -
TM7 2757 A 7.43x42 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM7 2758 G 7.44x43 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM7 2759 L 7.45x44 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 2760 C 7.46x45 GLP-1 receptor 5NX2 - -
TM7 2761 G 7.47x46 GLP-1 receptor 5NX2 - -
TM7 2762 L 7.48x47 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 2763 Q 7.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 2764 G 7.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 2765 L 7.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 2766 A 7.52x52 GLP-1 receptor 5NX2 - -
TM7 2767 V 7.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 2768 L 7.54x54 GLP-1 receptor 5NX2 - -
TM7 2769 L 7.55x55 GLP-1 receptor 5NX2 GLP-2 receptor 7D68
TM7 2770 L 7.56x56 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 2771 F 7.57x57 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM7 2772 C 7.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 2773 V 7.59x59 GLP-1 receptor 5NX2 - -
TM7 2774 L 7.60x60 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM7 2775 N 7.61x61 ADGRG3 7D77 - -
H8 2776 A 8.48x48 GLP-1 receptor 5NX2 - -
H8 2777 D 8.49x49 GLP-1 receptor 5NX2 - -
H8 2778 A 8.50x50 GLP-1 receptor 5NX2 - -
H8 2779 R 8.51x51 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
H8 2780 A 8.52x52 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
H8 2781 A 8.53x53 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
H8 2782 W 8.54x54 GLP-1 receptor 5NX2 - -
H8 2783 M 8.55x55 GLP-1 receptor 5NX2 - -
H8 2784 P 8.56x56 GLP-1 receptor 5NX2 - -
H8 2785 A 8.57x57 GLP-1 receptor 5NX2 - -
H8 2786 C 8.58x58 CRF2 receptor 6PB1 - -
H8 2787 L 8.59x59 CRF2 receptor 6PB1 - -
H8 2788 G 8.60x60 CRF2 receptor 6PB1 GHRH receptor 7CZ5
H8 2789 R 8.61x61 CRF2 receptor 6PB1 - -
H8 2790 K 8.62x62 CRF2 receptor 6PB1 CT receptor 6NIY
H8 2791 A 8.63x63 CRF2 receptor 6PB1 - -
C-term 2792 A - - - - -
C-term 2793 P - - - - -
C-term 2794 E - - - - -
C-term 2795 E - - - - -
C-term 2796 A - - - - -