FFA2 receptor homology model
PROTEIN CLASS
Class A (Rhodopsin)
RECEPTOR
SPECIES
Homo sapiens
STATE
Intermediate
VERSION
2021-02-08
MODEL
TEMPLATES
5NDD (PAR2)
5NDZ (PAR2)
7D7M (EP4 receptor)
5TZY (FFA1 receptor)
6PWC (NTS1 receptor)
5UIW (CCR5)
3VW7 (PAR1)
6ME2 (MT1 receptor)
None
5NDZ (PAR2)
7D7M (EP4 receptor)
5TZY (FFA1 receptor)
6PWC (NTS1 receptor)
5UIW (CCR5)
3VW7 (PAR1)
6ME2 (MT1 receptor)
None
| Main template (%) | Additional templates (%) | No template - freely modelled (%) | |
|---|---|---|---|
| Backbone | 78.7 | 13.5 | 7.8 |
| Side-chains | 22.3 | 58.8 | 18.9 |
Number of backbone templates: 8
Number of rotamer templates: 46
| Segment | Seq.num. | AA | GPCRdb# | Backbone | PDB | Rotamer | PDB |
|---|---|---|---|---|---|---|---|
| N-term | 1 | M | PAR2 | 5NDD | PAR2 | 5NDD | |
| N-term | 2 | L | PAR2 | 5NDD | PAR2 | 5NDD | |
| TM1 | 3 | P | 1.28x28 | PAR2 | 5NDD | MT1 receptor | 6ME2 |
| TM1 | 4 | D | 1.29x29 | PAR2 | 5NDD | CysLT1 receptor | 6RZ5 |
| TM1 | 5 | W | 1.30x30 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM1 | 6 | K | 1.31x31 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM1 | 7 | S | 1.32x32 | PAR2 | 5NDD | CCR9 | 5LWE |
| TM1 | 8 | S | 1.33x33 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM1 | 9 | L | 1.34x34 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM1 | 10 | I | 1.35x35 | PAR2 | 5NDD | κ receptor | 6B73 |
| TM1 | 11 | L | 1.36x36 | PAR2 | 5NDD | D4 receptor | 5WIV |
| TM1 | 12 | M | 1.37x37 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM1 | 13 | A | 1.38x38 | PAR2 | 5NDD | CCR6 | 6WWZ |
| TM1 | 14 | Y | 1.39x39 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 15 | I | 1.40x40 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM1 | 16 | I | 1.41x41 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 17 | I | 1.42x42 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM1 | 18 | F | 1.43x43 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 19 | L | 1.44x44 | PAR2 | 5NDD | H1 receptor | 3RZE |
| TM1 | 20 | T | 1.45x45 | PAR2 | 5NDD | CXCR4 | 3ODU |
| TM1 | 21 | G | 1.46x46 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM1 | 22 | L | 1.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 23 | P | 1.48x48 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 24 | A | 1.49x49 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM1 | 25 | N | 1.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 26 | L | 1.51x51 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM1 | 27 | L | 1.52x52 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM1 | 28 | A | 1.53x53 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 29 | L | 1.54x54 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 30 | R | 1.55x55 | PAR2 | 5NDD | FFA1 receptor | 5TZR |
| TM1 | 31 | A | 1.56x56 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM1 | 32 | F | 1.57x57 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 33 | V | 1.58x58 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM1 | 34 | G | 1.59x59 | PAR2 | 5NDD | TP receptor | 6IIV |
| TM1 | 35 | R | 1.60x60 | PAR2 | 5NDD | PAR2 | 5NDD |
| ICL1 | 36 | I | - | - | - | - | |
| ICL1 | 37 | R | EP4 receptor | 7D7M | - | - | |
| ICL1 | 38 | Q | EP4 receptor | 7D7M | - | - | |
| ICL1 | 39 | P | EP4 receptor | 7D7M | - | - | |
| ICL1 | 40 | Q | EP4 receptor | 7D7M | - | - | |
| ICL1 | 41 | P | - | - | - | - | |
| TM2 | 42 | A | 2.37x37 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 43 | P | 2.38x38 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 44 | V | 2.39x39 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM2 | 45 | H | 2.40x40 | PAR2 | 5NDD | NTS1 receptor | 4XES |
| TM2 | 46 | I | 2.41x41 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 47 | L | 2.42x42 | PAR2 | 5NDD | D3 receptor | 3PBL |
| TM2 | 48 | L | 2.43x43 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM2 | 49 | L | 2.44x44 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM2 | 50 | S | 2.45x45 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM2 | 51 | L | 2.46x46 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 52 | T | 2.47x47 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM2 | 53 | L | 2.48x48 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 54 | A | 2.49x49 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 55 | D | 2.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 56 | L | 2.51x51 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 57 | L | 2.52x52 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 58 | L | 2.53x53 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM2 | 59 | L | 2.54x54 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM2 | 60 | L | 2.55x55 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM2 | 61 | L | 2.56x56 | PAR2 | 5NDD | - | - |
| TM2 | 62 | L | 2.57x57 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM2 | 63 | P | 2.58x58 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 64 | F | 2.59x59 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM2 | 65 | K | 2.60x60 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 66 | I | 2.61x61 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 67 | I | 2.62x62 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM2 | 68 | E | 2.63x63 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM2 | 69 | A | 2.64x64 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM2 | 70 | A | 2.65x65 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM2 | 71 | S | 2.66x66 | PAR2 | 5NDD | PAR1 | 3VW7 |
| ECL1 | 72 | N | - | - | - | - | |
| ECL1 | 73 | F | PAR2 | 5NDZ | - | - | |
| ECL1 | 74 | R | 23.49x49 | PAR2 | 5NDZ | AT1 receptor | 4ZUD |
| ECL1 | 75 | W | 23.50x50 | PAR2 | 5NDZ | PAR2 | 5NDZ |
| ECL1 | 76 | Y | 23.51x51 | PAR2 | 5NDZ | CXCR4 | 3ODU |
| ECL1 | 77 | L | 23.52x52 | - | - | - | - |
| TM3 | 78 | P | 3.21x21 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM3 | 79 | K | 3.22x22 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM3 | 80 | V | 3.23x23 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM3 | 81 | V | 3.24x24 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM3 | 82 | C | 3.25x25 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 83 | A | 3.26x26 | PAR2 | 5NDD | 5-HT2A receptor | 6A94 |
| TM3 | 84 | L | 3.27x27 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM3 | 85 | T | 3.28x28 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM3 | 86 | S | 3.29x29 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM3 | 87 | F | 3.30x30 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM3 | 88 | G | 3.31x31 | PAR2 | 5NDD | CB1 receptor | 5TGZ |
| TM3 | 89 | F | 3.32x32 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 90 | Y | 3.33x33 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 91 | S | 3.34x34 | PAR2 | 5NDD | ghrelin receptor | 6KO5 |
| TM3 | 92 | S | 3.35x35 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM3 | 93 | I | 3.36x36 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM3 | 94 | Y | 3.37x37 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 95 | C | 3.38x38 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 96 | S | 3.39x39 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 97 | T | 3.40x40 | PAR2 | 5NDD | Y2 receptor | 7DDZ |
| TM3 | 98 | W | 3.41x41 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM3 | 99 | L | 3.42x42 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM3 | 100 | L | 3.43x43 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 101 | A | 3.44x44 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM3 | 102 | G | 3.45x45 | PAR2 | 5NDD | MT1 receptor | 6ME2 |
| TM3 | 103 | I | 3.46x46 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM3 | 104 | S | 3.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 105 | I | 3.48x48 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM3 | 106 | E | 3.49x49 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM3 | 107 | R | 3.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 108 | Y | 3.51x51 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM3 | 109 | L | 3.52x52 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM3 | 110 | G | 3.53x53 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM3 | 111 | V | 3.54x54 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM3 | 112 | A | 3.55x55 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM3 | 113 | F | 3.56x56 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| ICL2 | 114 | P | 34.50x50 | - | - | - | - |
| ICL2 | 115 | V | 34.51x51 | FFA1 receptor | 5TZY | κ receptor | 6B73 |
| ICL2 | 116 | Q | 34.52x52 | FFA1 receptor | 5TZY | CysLT1 receptor | 6RZ5 |
| ICL2 | 117 | Y | 34.53x53 | FFA1 receptor | 5TZY | FFA1 receptor | 5TZY |
| ICL2 | 118 | K | 34.54x54 | FFA1 receptor | 5TZY | ghrelin receptor | 6KO5 |
| ICL2 | 119 | L | 34.55x55 | FFA1 receptor | 5TZY | AT1 receptor | 6OS2 |
| ICL2 | 120 | S | 34.56x56 | FFA1 receptor | 5TZY | - | - |
| ICL2 | 121 | R | 34.57x57 | - | - | - | - |
| TM4 | 122 | R | 4.38x38 | PAR2 | 5NDD | CCR9 | 5LWE |
| TM4 | 123 | P | 4.39x39 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM4 | 124 | L | 4.40x40 | PAR2 | 5NDD | P2Y12 receptor | 4PXZ |
| TM4 | 125 | Y | 4.41x41 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM4 | 126 | G | 4.42x42 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM4 | 127 | V | 4.43x43 | PAR2 | 5NDD | CCR5 | 5UIW |
| TM4 | 128 | I | 4.44x44 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM4 | 129 | A | 4.45x45 | PAR2 | 5NDD | apelin receptor | 5VBL |
| TM4 | 130 | A | 4.46x46 | PAR2 | 5NDD | - | - |
| TM4 | 131 | L | 4.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 132 | V | 4.48x48 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM4 | 133 | A | 4.49x49 | PAR2 | 5NDD | H1 receptor | 3RZE |
| TM4 | 134 | W | 4.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 135 | V | 4.51x51 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM4 | 136 | M | 4.52x52 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM4 | 137 | S | 4.53x53 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM4 | 138 | F | 4.54x54 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM4 | 139 | G | 4.55x55 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM4 | 140 | H | 4.56x56 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM4 | 141 | C | 4.57x57 | FFA1 receptor | 5TZY | CCR9 | 5LWE |
| TM4 | 142 | T | 4.58x58 | FFA1 receptor | 5TZY | - | - |
| TM4 | 143 | I | 4.59x59 | FFA1 receptor | 5TZY | FFA1 receptor | 5TZY |
| TM4 | 144 | V | 4.60x60 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM4 | 145 | I | 4.61x61 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM4 | 146 | I | 4.62x62 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| ECL2 | 147 | V | - | - | - | - | |
| ECL2 | 148 | Q | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 149 | Y | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 150 | L | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 151 | N | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 152 | T | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 153 | T | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 154 | E | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 155 | Q | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 156 | V | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 157 | R | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 158 | S | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 159 | G | NTS1 receptor | 6PWC | NTS1 receptor | 6PWC | |
| ECL2 | 160 | N | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 161 | E | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 162 | I | NTS1 receptor | 6PWC | - | - | |
| ECL2 | 163 | T | - | - | - | - | |
| ECL2 | 164 | C | 45.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| ECL2 | 165 | Y | 45.51x51 | PAR2 | 5NDD | - | - |
| ECL2 | 166 | E | 45.52x52 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| ECL2 | 167 | N | - | - | - | - | |
| ECL2 | 168 | F | CCR5 | 5UIW | CCR5 | 5UIW | |
| ECL2 | 169 | T | CCR5 | 5UIW | - | - | |
| ECL2 | 170 | D | CCR5 | 5UIW | - | - | |
| ECL2 | 171 | N | - | - | - | - | |
| TM5 | 172 | Q | 5.31x32 | PAR2 | 5NDD | NOP receptor | 5DHG |
| TM5 | 173 | L | 5.32x33 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM5 | 174 | D | 5.33x34 | PAR2 | 5NDD | - | - |
| TM5 | 175 | V | 5.34x35 | PAR2 | 5NDD | - | - |
| TM5 | 176 | V | 5.35x36 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM5 | 177 | L | 5.36x37 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM5 | 178 | P | 5.37x38 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM5 | 179 | V | 5.38x39 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM5 | 180 | R | 5.39x40 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM5 | 181 | L | 5.40x41 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 182 | E | 5.41x42 | PAR2 | 5NDD | US28 | 5WB1 |
| TM5 | 183 | L | 5.42x43 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 184 | C | 5.43x44 | PAR2 | 5NDD | α2A-adrenoceptor | 6KUX |
| TM5 | 185 | L | 5.44x45 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM5 | 186 | V | 5.45x46 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM5 | 187 | L | 5.46x461 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM5 | 188 | F | 5.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 189 | F | 5.48x48 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM5 | 190 | I | 5.49x49 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM5 | 191 | P | 5.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 192 | M | 5.51x51 | PAR2 | 5NDD | MT1 receptor | 6ME2 |
| TM5 | 193 | A | 5.52x52 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM5 | 194 | V | 5.53x53 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM5 | 195 | T | 5.54x54 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 196 | I | 5.55x55 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM5 | 197 | F | 5.56x56 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM5 | 198 | C | 5.57x57 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM5 | 199 | Y | 5.58x58 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 200 | W | 5.59x59 | PAR2 | 5NDD | D4 receptor | 5WIV |
| TM5 | 201 | R | 5.60x60 | PAR2 | 5NDD | MT1 receptor | 6ME2 |
| TM5 | 202 | F | 5.61x61 | PAR2 | 5NDD | - | - |
| TM5 | 203 | V | 5.62x62 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM5 | 204 | W | 5.63x63 | PAR2 | 5NDD | CB1 receptor | 5TGZ |
| TM5 | 205 | I | 5.64x64 | PAR2 | 5NDD | α2A-adrenoceptor | 6KUX |
| TM5 | 206 | M | 5.65x65 | PAR2 | 5NDD | ETB receptor | 5X93 |
| TM5 | 207 | L | 5.66x66 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM5 | 208 | S | 5.67x67 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| ICL3 | 209 | Q | - | - | - | - | |
| ICL3 | 210 | P | - | - | - | - | |
| ICL3 | 211 | L | - | - | - | - | |
| ICL3 | 212 | V | - | - | - | - | |
| TM6 | 213 | G | 6.26x27 | PAR2 | 5NDD | CXCR4 | 3ODU |
| TM6 | 214 | A | 6.27x28 | PAR2 | 5NDD | α2C-adrenoceptor | 6KUW |
| TM6 | 215 | Q | 6.28x29 | PAR2 | 5NDD | CXCR4 | 3ODU |
| TM6 | 216 | R | 6.29x30 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM6 | 217 | R | 6.30x31 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 218 | R | 6.31x32 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM6 | 219 | R | 6.32x33 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 220 | A | 6.33x34 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 221 | V | 6.34x35 | PAR2 | 5NDD | MT1 receptor | 6ME2 |
| TM6 | 222 | G | 6.35x36 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM6 | 223 | L | 6.36x37 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 224 | A | 6.37x38 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 225 | V | 6.38x39 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 226 | V | 6.39x40 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM6 | 227 | T | 6.40x41 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM6 | 228 | L | 6.41x42 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM6 | 229 | L | 6.42x43 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM6 | 230 | N | 6.43x44 | PAR2 | 5NDD | - | - |
| TM6 | 231 | F | 6.44x45 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM6 | 232 | L | 6.45x46 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 233 | V | 6.46x461 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM6 | 234 | C | 6.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 235 | F | 6.48x48 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 236 | G | 6.49x49 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM6 | 237 | P | 6.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 238 | Y | 6.51x51 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM6 | 239 | N | 6.52x52 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 240 | V | 6.53x53 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM6 | 241 | S | 6.54x54 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM6 | 242 | H | 6.55x55 | PAR2 | 5NDD | D3 receptor | 3PBL |
| TM6 | 243 | L | 6.56x56 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM6 | 244 | V | 6.57x57 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 245 | G | 6.58x58 | PAR2 | 5NDD | α2B-adrenoceptor | 6K42 |
| TM6 | 246 | Y | 6.59x59 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 247 | H | 6.60x60 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM6 | 248 | Q | 6.61x61 | PAR2 | 5NDD | CCR5 | 5UIW |
| ECL3 | 249 | R | - | - | - | - | |
| ECL3 | 250 | K | - | - | - | - | |
| ECL3 | 251 | S | - | - | - | - | |
| ECL3 | 252 | P | - | - | - | - | |
| TM7 | 253 | W | 7.33x32 | PAR2 | 5NDD | MT1 receptor | 6ME2 |
| TM7 | 254 | W | 7.34x33 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM7 | 255 | R | 7.35x34 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM7 | 256 | S | 7.36x35 | PAR2 | 5NDD | CXCR4 | 3ODU |
| TM7 | 257 | I | 7.37x36 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM7 | 258 | A | 7.38x37 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 259 | V | 7.39x38 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM7 | 260 | V | 7.40x39 | PAR2 | 5NDD | CCR6 | 6WWZ |
| TM7 | 261 | F | 7.41x40 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM7 | 262 | S | 7.42x41 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 263 | S | 7.43x42 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM7 | 264 | L | 7.44x43 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 265 | N | 7.45x45 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 266 | A | 7.46x46 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM7 | 267 | S | 7.47x47 | PAR2 | 5NDD | κ receptor | 6B73 |
| TM7 | 268 | L | 7.48x48 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM7 | 269 | D | 7.49x49 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 270 | P | 7.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 271 | L | 7.51x51 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM7 | 272 | L | 7.52x52 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM7 | 273 | F | 7.53x53 | PAR2 | 5NDD | - | - |
| TM7 | 274 | Y | 7.54x54 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 275 | F | 7.55x55 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 276 | S | 7.56x56 | PAR2 | 5NDD | GPR52 | 6LI1 |
| H8 | 277 | S | 8.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| H8 | 278 | S | 8.48x48 | PAR2 | 5NDD | GPR52 | 6LI1 |
| H8 | 279 | V | 8.49x49 | PAR2 | 5NDD | GPR52 | 6LI3 |
| H8 | 280 | V | 8.50x50 | PAR2 | 5NDD | TP receptor | 6IIV |
| H8 | 281 | R | 8.51x51 | PAR2 | 5NDD | PAR2 | 5NDD |
| H8 | 282 | R | 8.52x52 | PAR2 | 5NDD | TP receptor | 6IIV |
| H8 | 283 | A | 8.53x53 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| H8 | 284 | F | 8.54x54 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| H8 | 285 | G | 8.55x55 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| H8 | 286 | R | 8.56x56 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| H8 | 287 | G | 8.57x57 | PAR2 | 5NDD | - | - |
| H8 | 288 | L | 8.58x58 | PAR2 | 5NDD | PAR2 | 5NDD |
| H8 | 289 | Q | 8.59x59 | MT1 receptor | 6ME2 | CCR5 | 5UIW |
| H8 | 290 | V | 8.60x60 | MT1 receptor | 6ME2 | - | - |
| H8 | 291 | L | 8.61x61 | MT1 receptor | 6ME2 | MT1 receptor | 6ME3 |
| C-term | 292 | R | - | - | - | - | |
| C-term | 293 | N | - | - | - | - | |
| C-term | 294 | Q | - | - | - | - | |
| C-term | 295 | G | - | - | - | - | |
| C-term | 296 | S | - | - | - | - |