GPRC5B homology model

PROTEIN CLASS

Class C (Glutamate)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-05-12

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

mGlu5 receptor (sequence similarity: 10%) PDB: 6N51

TEMPLATES

6N51 (mGlu5 receptor)
4OO9 (mGlu5 receptor)
4OR2 (mGlu1 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 73.1 6.5 20.4
Side-chains 22.8 12.9 64.3

Number of backbone templates: 3
Number of rotamer templates: 7

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 23 I - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 24 T - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 25 S - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 26 V - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 27 A - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 28 S - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 29 E - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 30 N - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 31 A - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 32 S - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 33 T - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 34 S - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 35 R - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 36 G - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 37 C - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 38 G - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 39 L - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 40 D - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 41 L - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 42 L - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 43 P - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 44 Q - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 45 Y - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 46 V - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 47 S - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 48 L - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 49 C - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 50 D - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 51 L - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 52 D - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 53 A - mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 54 I 1.38x38 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM1 55 W 1.39x39 mGlu5 receptor 6N51 - -
TM1 56 G 1.40x40 mGlu5 receptor 6N51 CaS receptor 7DTU
TM1 57 I 1.41x41 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 58 V 1.42x42 mGlu5 receptor 6N51 - -
TM1 59 V 1.43x43 mGlu5 receptor 6N51 GABAB1 6W2Y
TM1 60 E 1.44x44 mGlu5 receptor 6N51 - -
TM1 61 A 1.45x45 mGlu5 receptor 6N51 GABAB2 7CA5
TM1 62 V 1.46x46 mGlu5 receptor 6N51 - -
TM1 63 A 1.47x47 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 64 G 1.48x48 mGlu5 receptor 6N51 - -
TM1 65 A 1.49x49 mGlu5 receptor 6N51 - -
TM1 66 G 1.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 67 A 1.51x51 mGlu5 receptor 6N51 - -
TM1 68 L 1.52x52 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 69 I 1.53x53 mGlu5 receptor 6N51 - -
TM1 70 T 1.54x54 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 71 L 1.55x55 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 72 L 1.56x56 mGlu5 receptor 6N51 - -
TM1 73 L 1.57x57 mGlu5 receptor 6N51 - -
TM1 74 M 1.58x58 mGlu5 receptor 6N51 - -
TM1 75 L 1.59x59 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM1 76 I 1.60x60 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM1 77 L 1.61x61 mGlu5 receptor 6N51 - -
TM1 78 L 1.62x62 mGlu5 receptor 6N51 - -
TM1 79 V 1.63x63 mGlu1 receptor 4OR2 - -
TM1 80 R 1.64x64 mGlu1 receptor 4OR2 - -
ICL1 81 L 12.47x47 - - - -
ICL1 82 P 12.48x48 - - - -
ICL1 83 F 12.49x49 - - - -
ICL1 84 I 12.50x50 - - - -
ICL1 85 K 12.51x51 - - - -
ICL1 86 E 12.52x52 - - - -
ICL1 87 K 12.53x53 - - - -
TM2 88 E 2.31x31 - - - -
TM2 89 K 2.32x32 - - - -
TM2 90 K 2.33x33 - - - -
TM2 91 S 2.34x34 - - - -
TM2 92 P 2.35x35 mGlu5 receptor 6N51 - -
TM2 93 V 2.36x36 mGlu5 receptor 6N51 - -
TM2 94 G 2.37x37 mGlu5 receptor 6N51 - -
TM2 95 L 2.38x38 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 96 H 2.39x39 mGlu5 receptor 6N51 - -
TM2 97 F 2.40x40 mGlu5 receptor 6N51 - -
TM2 98 L 2.41x41 mGlu5 receptor 6N51 GABAB2 7C7Q
TM2 99 F 2.42x42 mGlu5 receptor 6N51 - -
TM2 100 L 2.43x43 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 101 L 2.44x44 mGlu5 receptor 6N51 GABAB2 7C7Q
TM2 102 G 2.45x45 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 103 T 2.46x46 mGlu5 receptor 6N51 - -
TM2 104 L 2.47x47 mGlu5 receptor 6N51 - -
TM2 105 G 2.48x48 mGlu5 receptor 6N51 - -
TM2 106 L 2.49x49 mGlu5 receptor 6N51 - -
TM2 107 F 2.50x50 mGlu5 receptor 6N51 - -
TM2 108 G 2.51x51 mGlu5 receptor 6N51 - -
TM2 109 L 2.52x52 mGlu5 receptor 6N51 - -
TM2 110 T 2.53x53 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 111 F 2.54x54 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 112 A 2.55x55 mGlu5 receptor 6N51 - -
TM2 113 F 2.56x56 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM2 114 I 2.57x57 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ECL1 115 I - - - - -
ECL1 116 Q - mGlu1 receptor 4OR2 - -
ECL1 117 E - mGlu1 receptor 4OR2 - -
ECL1 118 D - - - - -
TM3 119 E 3.26x26 mGlu5 receptor 6N51 GABAB2 7C7Q
TM3 120 T 3.27x27 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM3 121 I 3.28x28 mGlu5 receptor 6N51 - -
TM3 122 C 3.29x29 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 123 S 3.30x30 mGlu5 receptor 6N51 - -
TM3 124 V 3.31x31 mGlu5 receptor 6N51 GABAB2 7C7Q
TM3 125 R 3.32x32 mGlu5 receptor 6N51 GABAB2 7C7Q
TM3 126 R 3.33x33 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM3 127 F 3.34x34 mGlu5 receptor 6N51 - -
TM3 128 L 3.35x35 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM3 129 W 3.36x36 mGlu5 receptor 6N51 - -
TM3 130 G 3.37x37 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 131 V 3.38x38 mGlu5 receptor 6N51 GABAB2 7C7Q
TM3 132 L 3.39x39 mGlu5 receptor 6N51 - -
TM3 133 F 3.40x40 mGlu5 receptor 6N51 GABAB1 6W2Y
TM3 134 A 3.41x41 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 135 L 3.42x42 mGlu5 receptor 6N51 GABAB1 6W2Y
TM3 136 C 3.43x43 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM3 137 F 3.44x44 mGlu5 receptor 6N51 GABAB2 7C7Q
TM3 138 S 3.45x45 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 139 C 3.46x46 mGlu5 receptor 6N51 - -
TM3 140 L 3.47x47 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 141 L 3.48x48 mGlu5 receptor 6N51 - -
TM3 142 S 3.49x49 mGlu5 receptor 6N51 - -
TM3 143 Q 3.50x50 mGlu5 receptor 6N51 - -
TM3 144 A 3.51x51 mGlu5 receptor 6N51 - -
TM3 145 W 3.52x52 mGlu5 receptor 6N51 GABAB2 7C7Q
TM3 146 R 3.53x53 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 147 V 3.54x54 mGlu5 receptor 6N51 GABAB2 7C7Q
TM3 148 R 3.55x55 mGlu5 receptor 6N51 - -
TM3 149 R 3.56x56 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 150 L 3.57x57 mGlu5 receptor 6N51 - -
TM3 151 V 3.58x58 mGlu5 receptor 6N51 - -
ICL2 152 R - - - - -
ICL2 153 H - - - - -
ICL2 154 G - - - - -
ICL2 155 T - - - - -
ICL2 156 G - - - - -
ICL2 157 P - - - - -
TM4 158 A 4.28x28 mGlu5 receptor 6N51 - -
TM4 159 G 4.29x29 mGlu5 receptor 6N51 - -
TM4 160 W 4.30x30 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM4 161 Q 4.31x31 mGlu5 receptor 6N51 - -
TM4 162 L 4.32x32 mGlu5 receptor 6N51 GABAB2 7C7Q
TM4 163 V 4.33x33 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM4 164 G 4.34x34 mGlu5 receptor 6N51 - -
TM4 165 L 4.35x35 mGlu5 receptor 6N51 - -
TM4 166 A 4.36x36 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 167 L 4.37x37 mGlu5 receptor 6N51 - -
TM4 168 C 4.38x38 mGlu5 receptor 6N51 - -
TM4 169 L 4.39x39 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 170 M 4.40x40 mGlu5 receptor 6N51 - -
TM4 171 L 4.41x41 mGlu5 receptor 6N51 GABAB2 7C7Q
TM4 172 V 4.42x42 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM4 173 Q 4.43x43 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 174 V 4.44x44 mGlu5 receptor 6N51 - -
TM4 175 I 4.45x45 mGlu5 receptor 6N51 - -
TM4 176 I 4.46x46 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 177 A 4.47x47 mGlu5 receptor 6N51 - -
TM4 178 V 4.48x48 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM4 179 E 4.49x49 mGlu5 receptor 6N51 - -
TM4 180 W 4.50x50 mGlu5 receptor 6N51 GABAB2 7C7Q
TM4 181 L 4.51x51 mGlu5 receptor 6N51 - -
TM4 182 V 4.52x52 mGlu5 receptor 6N51 - -
TM4 183 L 4.53x53 mGlu5 receptor 6N51 - -
TM4 184 T 4.54x54 mGlu5 receptor 6N51 - -
ECL2 185 V - - - - -
ECL2 186 L - - - - -
ECL2 187 R - - - - -
ECL2 188 D - - - - -
ECL2 189 T - - - - -
ECL2 190 R - - - - -
ECL2 191 P - - - - -
ECL2 192 A - - - - -
ECL2 193 C 45.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
ECL2 194 A 45.51x51 mGlu5 receptor 6N51 - -
ECL2 195 Y 45.52x52 mGlu5 receptor 6N51 - -
TM5 196 E 5.36x36 mGlu1 receptor 4OR2 - -
TM5 197 P 5.37x37 mGlu5 receptor 6N51 - -
TM5 198 M 5.38x38 mGlu5 receptor 6N51 - -
TM5 199 D 5.39x39 mGlu5 receptor 6N51 - -
TM5 200 F 5.40x40 mGlu5 receptor 6N51 - -
TM5 201 V 5.41x41 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 202 M 5.42x42 mGlu5 receptor 6N51 - -
TM5 203 A 5.43x43 mGlu5 receptor 6N51 - -
TM5 204 L 5.44x44 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 205 I 5.45x45 mGlu5 receptor 6N51 - -
TM5 206 Y 5.46x46 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM5 207 D 5.47x47 mGlu5 receptor 6N51 - -
TM5 208 M 5.48x48 mGlu5 receptor 6N51 - -
TM5 209 V 5.49x49 mGlu5 receptor 6N51 - -
TM5 210 L 5.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 211 L 5.51x51 mGlu5 receptor 6N51 GABAB1 6W2Y
TM5 212 V 5.52x52 mGlu5 receptor 6N51 - -
TM5 213 V 5.53x53 mGlu5 receptor 6N51 - -
TM5 214 T 5.54x54 mGlu5 receptor 6N51 - -
TM5 215 L 5.55x55 mGlu5 receptor 6N51 - -
TM5 216 G 5.56x56 mGlu5 receptor 6N51 - -
TM5 217 L 5.57x57 mGlu5 receptor 6N51 GABAB2 7C7Q
TM5 218 A 5.58x58 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 219 L 5.59x59 mGlu1 receptor 4OR2 - -
TM5 220 F 5.60x60 mGlu1 receptor 4OR2 - -
TM5 221 T 5.61x61 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ICL3 222 L - - - - -
ICL3 223 C - - - - -
ICL3 224 G - - - - -
ICL3 225 K - - - - -
ICL3 226 F - - - - -
ICL3 227 K - - - - -
ICL3 228 R - - - - -
ICL3 229 W - - - - -
ICL3 230 K - - - - -
ICL3 231 L - - - - -
TM6 232 N 6.35x35 mGlu5 receptor 6N51 - -
TM6 233 G 6.36x36 mGlu5 receptor 6N51 - -
TM6 234 A 6.37x37 mGlu5 receptor 6N51 - -
TM6 235 F 6.38x38 mGlu5 receptor 6N51 - -
TM6 236 L 6.39x39 mGlu5 receptor 6N51 - -
TM6 237 L 6.40x40 mGlu5 receptor 6N51 - -
TM6 238 I 6.41x41 mGlu5 receptor 6N51 - -
TM6 239 T 6.42x42 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 240 A 6.43x43 mGlu5 receptor 6N51 - -
TM6 241 F 6.44x44 mGlu5 receptor 6N51 - -
TM6 242 L 6.45x45 mGlu5 receptor 6N51 - -
TM6 243 S 6.46x46 mGlu5 receptor 6N51 - -
TM6 244 V 6.47x47 mGlu5 receptor 6N51 - -
TM6 245 L 6.48x48 mGlu5 receptor 6N51 - -
TM6 246 I 6.49x49 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 247 W 6.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 248 V 6.51x51 mGlu5 receptor 6N51 - -
TM6 249 A 6.52x52 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 250 W 6.53x53 mGlu5 receptor 6N51 - -
TM6 251 M 6.54x54 mGlu5 receptor 6N51 - -
TM6 252 T 6.55x55 mGlu5 receptor 6N51 - -
TM6 253 M 6.56x56 mGlu5 receptor 6N51 - -
TM6 254 Y 6.57x57 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM6 255 L 6.58x58 mGlu5 receptor 6N51 - -
TM6 256 F 6.59x59 mGlu5 receptor 6N51 - -
TM6 257 G 6.60x60 mGlu5 receptor 4OO9 - -
ECL3 258 N - - - - -
ECL3 259 V - - - - -
ECL3 260 K - - - - -
ECL3 261 L - - - - -
ECL3 262 Q - - - - -
ECL3 263 Q - - - - -
ECL3 264 G - - - - -
ECL3 265 D - - - - -
ECL3 266 A - - - - -
TM7 267 W 7.27x28 mGlu1 receptor 4OR2 - -
TM7 268 N 7.28x29 mGlu1 receptor 4OR2 - -
TM7 269 D 7.29x30 mGlu5 receptor 6N51 - -
TM7 270 P 7.30x31 mGlu5 receptor 6N51 - -
TM7 271 T 7.31x32 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 272 L 7.32x33 mGlu5 receptor 6N51 - -
TM7 273 A 7.33x34 mGlu5 receptor 6N51 GABAB2 7CA5
TM7 274 I 7.34x35 mGlu5 receptor 6N51 - -
TM7 275 T 7.35x36 mGlu5 receptor 6N51 - -
TM7 276 L 7.36x37 mGlu5 receptor 6N51 - -
TM7 277 A 7.37x38 mGlu5 receptor 6N51 - -
TM7 278 A 7.38x39 mGlu5 receptor 6N51 CaS receptor 7DTU
TM7 279 S 7.39x40 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 280 G 7.40x41 mGlu5 receptor 6N51 - -
TM7 281 W 7.41x42 mGlu5 receptor 6N51 - -
TM7 282 V 7.42x43 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 283 F 7.43x44 mGlu5 receptor 6N51 - -
TM7 284 V 7.44x45 mGlu5 receptor 6N51 - -
TM7 285 I 7.45x46 mGlu5 receptor 6N51 - -
TM7 286 F 7.46x47 mGlu5 receptor 6N51 - -
TM7 287 H 7.47x471 mGlu5 receptor 6N51 - -
TM7 288 A 7.48x48 mGlu5 receptor 6N51 - -
TM7 289 I 7.49x49 mGlu5 receptor 6N51 - -
TM7 290 P 7.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 291 E 7.51x51 mGlu5 receptor 6N51 - -
TM7 292 I 7.52x52 mGlu5 receptor 6N51 - -
TM7 293 H 7.53x53 mGlu5 receptor 6N51 - -
TM7 294 C 7.54x54 mGlu5 receptor 6N51 - -
TM7 295 T 7.55x55 mGlu5 receptor 6N51 - -
TM7 296 L 7.56x56 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 297 L 7.57x57 mGlu1 receptor 4OR2 - -
TM7 298 P 7.58x58 mGlu1 receptor 4OR2 - -
ICL4 299 A - - - - -
H8 300 L 8.46x46 mGlu5 receptor 4OO9 - -
H8 301 Q 8.47x47 mGlu5 receptor 4OO9 - -
H8 302 E 8.48x48 mGlu5 receptor 4OO9 - -
H8 303 N 8.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 304 T 8.50x50 - - - -
H8 305 P 8.51x51 - - - -
H8 306 N 8.52x52 - - - -
H8 307 Y 8.53x53 - - - -
H8 308 F 8.54x54 - - - -
H8 309 D 8.55x55 - - - -
H8 310 T 8.56x56 - - - -
H8 311 S 8.57x57 - - - -
C-term 312 Q - - - - -
C-term 313 P - - - - -
C-term 314 R - - - - -
C-term 315 M - - - - -
C-term 316 R - - - - -