GPRC5C homology model

PROTEIN CLASS

Class C (Glutamate)

RECEPTOR

GPRC5C

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2022-06-19

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

mGlu5 receptor (sequence similarity: 9%) PDB: 6N51
Align

TEMPLATES

6N51 (mGlu5 receptor)
4OO9 (mGlu5 receptor)
4OR2 (mGlu1 receptor)
7WIH (mGlu3 receptor)
7WI8 (mGlu3 receptor)
7WI6 (mGlu3 receptor)
6W2X (GABAB2)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 69.5 11.6 18.9
Side-chains 18.9 20.9 60.3

Number of backbone templates: 7
Number of rotamer templates: 14

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 23 A - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 24 Q - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 25 G - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 26 H - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 27 V - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 28 P - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 29 P - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 30 G - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 31 C - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 32 S - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 33 Q - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 34 G - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 35 L - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 36 N - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 37 P - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 38 L - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 39 Y - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 40 Y - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 41 N - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 42 L - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 43 C - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 44 D - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 45 R - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 46 S - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 47 G - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 48 A - mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 49 W 1.39x39 mGlu5 receptor 6N51 mGlu2 receptor 7EPE
TM1 50 G 1.40x40 mGlu5 receptor 6N51 CaS receptor 7DD5
TM1 51 I 1.41x41 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 52 V 1.42x42 mGlu5 receptor 6N51 - -
TM1 53 L 1.43x43 mGlu5 receptor 6N51 CaS receptor 7DD5
TM1 54 E 1.44x44 mGlu5 receptor 6N51 - -
TM1 55 A 1.45x45 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM1 56 V 1.46x46 mGlu5 receptor 6N51 - -
TM1 57 A 1.47x47 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 58 G 1.48x48 mGlu5 receptor 6N51 - -
TM1 59 A 1.49x49 mGlu5 receptor 6N51 - -
TM1 60 G 1.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 61 I 1.51x51 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM1 62 V 1.52x52 mGlu5 receptor 6N51 GABAB1 6W2Y
TM1 63 T 1.53x53 mGlu5 receptor 6N51 - -
TM1 64 T 1.54x54 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 65 F 1.55x55 mGlu5 receptor 6N51 GPR158 7SHE
TM1 66 V 1.56x56 mGlu5 receptor 6N51 GABAB1 6W2Y
TM1 67 L 1.57x57 mGlu5 receptor 6N51 - -
TM1 68 T 1.58x58 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM1 69 I 1.59x59 mGlu5 receptor 6N51 - -
TM1 70 I 1.60x60 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM1 71 L 1.61x61 mGlu5 receptor 6N51 - -
TM1 72 V 1.62x62 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM1 73 A 1.63x63 mGlu1 receptor 4OR2 - -
TM1 74 S 1.64x64 mGlu1 receptor 4OR2 - -
ICL1 75 L 12.47x47 - - - -
ICL1 76 P 12.48x48 - - - -
ICL1 77 F 12.49x49 - - - -
ICL1 78 V 12.50x50 - - - -
ICL1 79 Q 12.51x51 - - - -
ICL1 80 D 12.52x52 - - - -
ICL1 81 T 12.53x53 - - - -
TM2 82 K 2.31x31 - - - -
TM2 83 K 2.32x32 - - - -
TM2 84 R 2.33x33 - - - -
TM2 85 S 2.34x34 - - - -
TM2 86 L 2.35x35 mGlu5 receptor 6N51 - -
TM2 87 L 2.36x36 mGlu5 receptor 6N51 GPR158 7SHE
TM2 88 G 2.37x37 mGlu5 receptor 6N51 - -
TM2 89 T 2.38x38 mGlu5 receptor 6N51 - -
TM2 90 Q 2.39x39 mGlu5 receptor 6N51 - -
TM2 91 V 2.40x40 mGlu5 receptor 6N51 - -
TM2 92 F 2.41x41 mGlu5 receptor 6N51 - -
TM2 93 F 2.42x42 mGlu5 receptor 6N51 - -
TM2 94 L 2.43x43 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 95 L 2.44x44 mGlu5 receptor 6N51 GABAB2 7C7Q
TM2 96 G 2.45x45 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 97 T 2.46x46 mGlu5 receptor 6N51 - -
TM2 98 L 2.47x47 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 99 G 2.48x48 mGlu5 receptor 6N51 - -
TM2 100 L 2.49x49 mGlu5 receptor 6N51 GPR158 7SHE
TM2 101 F 2.50x50 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 102 C 2.51x51 mGlu5 receptor 6N51 mGlu2 receptor 7EPE
TM2 103 L 2.52x52 mGlu5 receptor 6N51 - -
TM2 104 V 2.53x53 mGlu5 receptor 6N51 GABAB1 6W2Y
TM2 105 F 2.54x54 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 106 A 2.55x55 mGlu5 receptor 6N51 - -
TM2 107 C 2.56x56 mGlu3 receptor 7WIH - -
TM2 108 V 2.57x57 mGlu3 receptor 7WIH - -
ECL1 109 V - - - - -
ECL1 110 K - mGlu3 receptor 7WIH - -
ECL1 111 P - - - - -
TM3 112 D 3.25x25 mGlu5 receptor 6N51 - -
TM3 113 F 3.26x26 mGlu5 receptor 6N51 - -
TM3 114 S 3.27x27 mGlu5 receptor 6N51 - -
TM3 115 T 3.28x28 mGlu5 receptor 6N51 mGlu4 receptor 7E9H
TM3 116 C 3.29x29 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 117 A 3.30x30 mGlu5 receptor 6N51 mGlu3 receptor 7WIH
TM3 118 S 3.31x31 mGlu5 receptor 6N51 - -
TM3 119 R 3.32x32 mGlu5 receptor 6N51 mGlu3 receptor 7WIH
TM3 120 R 3.33x33 mGlu5 receptor 6N51 mGlu3 receptor 7WIH
TM3 121 F 3.34x34 mGlu5 receptor 6N51 - -
TM3 122 L 3.35x35 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM3 123 F 3.36x36 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 124 G 3.37x37 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 125 V 3.38x38 mGlu5 receptor 6N51 GABAB2 7C7Q
TM3 126 L 3.39x39 mGlu5 receptor 6N51 - -
TM3 127 F 3.40x40 mGlu5 receptor 6N51 mGlu3 receptor 7WIH
TM3 128 A 3.41x41 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 129 I 3.42x42 mGlu5 receptor 6N51 mGlu3 receptor 7WIH
TM3 130 C 3.43x43 mGlu5 receptor 6N51 mGlu3 receptor 7WI6
TM3 131 F 3.44x44 mGlu5 receptor 6N51 GABAB2 7C7Q
TM3 132 S 3.45x45 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 133 C 3.46x46 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 134 L 3.47x47 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 135 A 3.48x48 mGlu5 receptor 6N51 - -
TM3 136 A 3.49x49 mGlu5 receptor 6N51 GABAB2 7C7Q
TM3 137 H 3.50x50 mGlu5 receptor 6N51 - -
TM3 138 V 3.51x51 mGlu5 receptor 6N51 - -
TM3 139 F 3.52x52 mGlu5 receptor 6N51 - -
TM3 140 A 3.53x53 mGlu5 receptor 6N51 - -
TM3 141 L 3.54x54 mGlu5 receptor 6N51 - -
TM3 142 N 3.55x55 mGlu5 receptor 6N51 - -
TM3 143 F 3.56x56 mGlu5 receptor 6N51 - -
TM3 144 L 3.57x57 mGlu5 receptor 6N51 - -
TM3 145 A 3.58x58 mGlu5 receptor 6N51 - -
ICL2 146 R - - - - -
ICL2 147 K - - - - -
ICL2 148 N - - - - -
ICL2 149 H - - - - -
ICL2 150 G - - - - -
ICL2 151 P - - - - -
TM4 152 R 4.28x28 mGlu5 receptor 6N51 - -
TM4 153 G 4.29x29 mGlu5 receptor 6N51 GPR158 7EWP
TM4 154 W 4.30x30 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM4 155 V 4.31x31 mGlu5 receptor 6N51 - -
TM4 156 I 4.32x32 mGlu5 receptor 6N51 - -
TM4 157 F 4.33x33 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 158 T 4.34x34 mGlu5 receptor 6N51 - -
TM4 159 V 4.35x35 mGlu5 receptor 6N51 - -
TM4 160 A 4.36x36 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 161 L 4.37x37 mGlu5 receptor 6N51 mGlu3 receptor 7WI6
TM4 162 L 4.38x38 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 163 L 4.39x39 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 164 T 4.40x40 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 165 L 4.41x41 mGlu5 receptor 6N51 mGlu3 receptor 7WI6
TM4 166 V 4.42x42 mGlu5 receptor 6N51 mGlu3 receptor 7WIH
TM4 167 E 4.43x43 mGlu5 receptor 6N51 - -
TM4 168 V 4.44x44 mGlu5 receptor 6N51 - -
TM4 169 I 4.45x45 mGlu5 receptor 6N51 - -
TM4 170 I 4.46x46 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 171 N 4.47x47 mGlu5 receptor 6N51 - -
TM4 172 T 4.48x48 mGlu5 receptor 6N51 - -
TM4 173 E 4.49x49 mGlu5 receptor 6N51 - -
TM4 174 W 4.50x50 mGlu5 receptor 6N51 mGlu2 receptor 7EPE
TM4 175 L 4.51x51 mGlu5 receptor 6N51 mGlu2 receptor 7EPE
TM4 176 I 4.52x52 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 177 I 4.53x53 mGlu5 receptor 6N51 - -
TM4 178 T 4.54x54 mGlu5 receptor 6N51 - -
ECL2 179 L - - - - -
ECL2 180 V - GABAB2 6W2X - -
ECL2 181 R - GABAB2 6W2X - -
ECL2 182 G - GABAB2 6W2X - -
ECL2 183 S - GABAB2 6W2X - -
ECL2 184 G - GABAB2 6W2X - -
ECL2 185 E - GABAB2 6W2X - -
ECL2 186 G - GABAB2 6W2X - -
ECL2 187 G - GABAB2 6W2X - -
ECL2 188 P - GABAB2 6W2X - -
ECL2 189 Q - GABAB2 6W2X - -
ECL2 190 G - GABAB2 6W2X - -
ECL2 191 N - GABAB2 6W2X - -
ECL2 192 S - - - - -
ECL2 193 S - - - - -
ECL2 194 A - - - - -
ECL2 195 G - - - - -
ECL2 196 W - - - - -
ECL2 197 A - GABAB2 6W2X - -
ECL2 198 V - GABAB2 6W2X - -
ECL2 199 A - GABAB2 6W2X - -
ECL2 200 S - GABAB2 6W2X - -
ECL2 201 P - - - - -
ECL2 202 C 45.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
ECL2 203 A 45.51x51 mGlu5 receptor 6N51 - -
ECL2 204 I 45.52x52 mGlu5 receptor 6N51 GPR158 7SHE
TM5 205 A 5.36x36 mGlu3 receptor 7WIH - -
TM5 206 N 5.37x37 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 207 M 5.38x38 mGlu5 receptor 6N51 CaS receptor 7DD5
TM5 208 D 5.39x39 mGlu5 receptor 6N51 - -
TM5 209 F 5.40x40 mGlu5 receptor 6N51 - -
TM5 210 V 5.41x41 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 211 M 5.42x42 mGlu5 receptor 6N51 GPR158 7SHE
TM5 212 A 5.43x43 mGlu5 receptor 6N51 - -
TM5 213 L 5.44x44 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 214 I 5.45x45 mGlu5 receptor 6N51 - -
TM5 215 Y 5.46x46 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM5 216 V 5.47x47 mGlu5 receptor 6N51 - -
TM5 217 M 5.48x48 mGlu5 receptor 6N51 - -
TM5 218 L 5.49x49 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 219 L 5.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 220 L 5.51x51 mGlu5 receptor 6N51 GABAB1 6W2Y
TM5 221 L 5.52x52 mGlu5 receptor 6N51 mGlu5 receptor 6FFI
TM5 222 G 5.53x53 mGlu5 receptor 6N51 - -
TM5 223 A 5.54x54 mGlu5 receptor 6N51 - -
TM5 224 F 5.55x55 mGlu5 receptor 6N51 CaS receptor 7DD5
TM5 225 L 5.56x56 mGlu5 receptor 6N51 mGlu2 receptor 7EPE
TM5 226 G 5.57x57 mGlu5 receptor 6N51 - -
TM5 227 A 5.58x58 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 228 W 5.59x59 mGlu3 receptor 7WI8 GABAB2 7C7Q
TM5 229 P 5.60x60 mGlu3 receptor 7WI8 - -
TM5 230 A 5.61x61 mGlu3 receptor 7WI8 - -
ICL3 231 L - - - - -
ICL3 232 C - - - - -
ICL3 233 G - - - - -
ICL3 234 R - - - - -
ICL3 235 Y - - - - -
ICL3 236 K - - - - -
ICL3 237 R - - - - -
ICL3 238 W - - - - -
ICL3 239 R - - - - -
ICL3 240 K - - - - -
TM6 241 H 6.35x35 mGlu5 receptor 6N51 - -
TM6 242 G 6.36x36 mGlu5 receptor 6N51 - -
TM6 243 V 6.37x37 mGlu5 receptor 6N51 - -
TM6 244 F 6.38x38 mGlu5 receptor 6N51 mGlu2 receptor 7EPE
TM6 245 V 6.39x39 mGlu5 receptor 6N51 - -
TM6 246 L 6.40x40 mGlu5 receptor 6N51 - -
TM6 247 L 6.41x41 mGlu5 receptor 6N51 - -
TM6 248 T 6.42x42 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 249 T 6.43x43 mGlu5 receptor 6N51 - -
TM6 250 A 6.44x44 mGlu5 receptor 6N51 - -
TM6 251 T 6.45x45 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 252 S 6.46x46 mGlu5 receptor 6N51 - -
TM6 253 V 6.47x47 mGlu5 receptor 6N51 - -
TM6 254 A 6.48x48 mGlu5 receptor 6N51 - -
TM6 255 I 6.49x49 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 256 W 6.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 257 V 6.51x51 mGlu5 receptor 6N51 - -
TM6 258 V 6.52x52 mGlu5 receptor 6N51 - -
TM6 259 W 6.53x53 mGlu5 receptor 6N51 - -
TM6 260 I 6.54x54 mGlu5 receptor 6N51 mGlu4 receptor 7E9H
TM6 261 V 6.55x55 mGlu5 receptor 6N51 - -
TM6 262 M 6.56x56 mGlu5 receptor 6N51 - -
TM6 263 Y 6.57x57 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM6 264 T 6.58x58 mGlu5 receptor 6N51 - -
TM6 265 Y 6.59x59 mGlu5 receptor 6N51 - -
TM6 266 G 6.60x60 mGlu3 receptor 7WI6 - -
ECL3 267 N - - - - -
ECL3 268 K - - - - -
ECL3 269 Q - - - - -
ECL3 270 H - - - - -
ECL3 271 N - - - - -
ECL3 272 S - - - - -
ECL3 273 P - - - - -
TM7 274 T 7.26x27 mGlu3 receptor 7WIH - -
TM7 275 W 7.27x28 mGlu3 receptor 7WIH GPR158 7SHE
TM7 276 D 7.28x29 mGlu3 receptor 7WIH - -
TM7 277 D 7.29x30 mGlu5 receptor 6N51 - -
TM7 278 P 7.30x31 mGlu5 receptor 6N51 - -
TM7 279 T 7.31x32 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 280 L 7.32x33 mGlu5 receptor 6N51 mGlu4 receptor 7E9H
TM7 281 A 7.33x34 mGlu5 receptor 6N51 GABAB2 7C7Q
TM7 282 I 7.34x35 mGlu5 receptor 6N51 mGlu3 receptor 7WI6
TM7 283 A 7.35x36 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM7 284 L 7.36x37 mGlu5 receptor 6N51 - -
TM7 285 A 7.37x38 mGlu5 receptor 6N51 - -
TM7 286 A 7.38x39 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 287 N 7.39x40 mGlu5 receptor 6N51 - -
TM7 288 A 7.40x41 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 289 W 7.41x42 mGlu5 receptor 6N51 - -
TM7 290 A 7.42x43 mGlu5 receptor 6N51 - -
TM7 291 F 7.43x44 mGlu5 receptor 6N51 - -
TM7 292 V 7.44x45 mGlu5 receptor 6N51 - -
TM7 293 L 7.45x46 mGlu5 receptor 6N51 - -
TM7 294 F 7.46x47 mGlu5 receptor 6N51 - -
TM7 295 Y 7.47x471 mGlu5 receptor 6N51 - -
TM7 296 V 7.48x48 mGlu5 receptor 6N51 - -
TM7 297 I 7.49x49 mGlu5 receptor 6N51 GPR158 7SHE
TM7 298 P 7.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 299 E 7.51x51 mGlu5 receptor 6N51 - -
TM7 300 V 7.52x52 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 301 S 7.53x53 mGlu5 receptor 6N51 GPR158 7SHF
TM7 302 Q 7.54x54 mGlu5 receptor 6N51 - -
TM7 303 V 7.55x55 mGlu5 receptor 6N51 - -
TM7 304 T 7.56x56 mGlu5 receptor 6N51 - -
TM7 305 K 7.57x57 mGlu1 receptor 4OR2 - -
TM7 306 S 7.58x58 mGlu1 receptor 4OR2 - -
ICL4 307 S - - - - -
H8 308 P 8.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 309 E 8.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 310 Q 8.48x48 mGlu5 receptor 4OO9 - -
H8 311 S 8.49x49 mGlu5 receptor 4OO9 - -
H8 312 Y 8.50x50 - - - -
H8 313 Q 8.51x51 - - - -
H8 314 G 8.52x52 - - - -
H8 315 D 8.53x53 - - - -
H8 316 M 8.54x54 - - - -
H8 317 Y 8.55x55 - - - -
H8 318 P 8.56x56 - - - -
H8 319 T 8.57x57 - - - -
C-term 320 R - - - - -
C-term 321 G - - - - -
C-term 322 V - - - - -
C-term 323 G - - - - -
C-term 324 Y - - - - -