GPRC6 receptor homology model

PROTEIN CLASS

Class C (Glutamate)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-06-10

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

mGlu5 receptor (sequence similarity: 18%) PDB: 6N51

TEMPLATES

7DTU (CaS receptor)
7DTW (CaS receptor)
7DTV (CaS receptor)
6N51 (mGlu5 receptor)
4OO9 (mGlu5 receptor)
4OR2 (mGlu1 receptor)
7C7Q (GABAB2)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 75.3 9.7 15.0
Side-chains 19.5 21.0 59.6

Number of backbone templates: 7
Number of rotamer templates: 9

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
TM1 591 D 1.37x37 CaS receptor 7DTU - -
TM1 592 S 1.38x38 mGlu5 receptor 6N51 - -
TM1 593 L 1.39x39 mGlu5 receptor 6N51 GABAB2 7C7Q
TM1 594 A 1.40x40 mGlu5 receptor 6N51 - -
TM1 595 I 1.41x41 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 596 L 1.42x42 mGlu5 receptor 6N51 - -
TM1 597 L 1.43x43 mGlu5 receptor 6N51 CaS receptor 7DTV
TM1 598 L 1.44x44 mGlu5 receptor 6N51 - -
TM1 599 I 1.45x45 mGlu5 receptor 6N51 - -
TM1 600 L 1.46x46 mGlu5 receptor 6N51 GABAB2 7C7Q
TM1 601 S 1.47x47 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM1 602 L 1.48x48 mGlu5 receptor 6N51 - -
TM1 603 L 1.49x49 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM1 604 G 1.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 605 I 1.51x51 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM1 606 I 1.52x52 mGlu5 receptor 6N51 GABAB2 7C7Q
TM1 607 F 1.53x53 mGlu5 receptor 6N51 - -
TM1 608 V 1.54x54 mGlu5 receptor 6N51 - -
TM1 609 L 1.55x55 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 610 V 1.56x56 mGlu5 receptor 6N51 GABAB1 6W2Y
TM1 611 V 1.57x57 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 612 G 1.58x58 mGlu5 receptor 6N51 - -
TM1 613 I 1.59x59 mGlu5 receptor 6N51 - -
TM1 614 I 1.60x60 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM1 615 F 1.61x61 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM1 616 T 1.62x62 mGlu5 receptor 6N51 - -
TM1 617 R 1.63x63 CaS receptor 7DTU - -
TM1 618 N 1.64x64 CaS receptor 7DTU GABAB2 7C7Q
ICL1 619 L - - - - -
ICL1 620 N - - - - -
ICL1 621 T 12.47x47 - - - -
ICL1 622 P 12.48x48 - - - -
ICL1 623 V 12.49x49 - - - -
ICL1 624 V 12.50x50 - - - -
ICL1 625 K 12.51x51 - - - -
ICL1 626 S 12.52x52 - - - -
ICL1 627 S 12.53x53 - - - -
TM2 628 G 2.34x34 - - - -
TM2 629 G 2.35x35 mGlu5 receptor 6N51 - -
TM2 630 L 2.36x36 mGlu5 receptor 6N51 - -
TM2 631 R 2.37x37 mGlu5 receptor 6N51 - -
TM2 632 V 2.38x38 mGlu5 receptor 6N51 - -
TM2 633 C 2.39x39 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 634 Y 2.40x40 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM2 635 V 2.41x41 mGlu5 receptor 6N51 - -
TM2 636 I 2.42x42 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 637 L 2.43x43 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 638 L 2.44x44 mGlu5 receptor 6N51 GABAB2 7C7Q
TM2 639 C 2.45x45 mGlu5 receptor 6N51 - -
TM2 640 H 2.46x46 mGlu5 receptor 6N51 - -
TM2 641 F 2.47x47 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM2 642 L 2.48x48 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 643 N 2.49x49 mGlu5 receptor 6N51 - -
TM2 644 F 2.50x50 mGlu5 receptor 6N51 - -
TM2 645 A 2.51x51 mGlu5 receptor 6N51 GABAB2 7CA5
TM2 646 S 2.52x52 mGlu5 receptor 6N51 GABAB2 7C7Q
TM2 647 T 2.53x53 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 648 S 2.54x54 mGlu5 receptor 6N51 - -
TM2 649 F 2.55x55 mGlu5 receptor 6N51 - -
TM2 650 F 2.56x56 CaS receptor 7DTW GABAB2 7C7Q
TM2 651 I 2.57x57 CaS receptor 7DTW mGlu5 receptor 6FFI
ECL1 652 G - - - - -
ECL1 653 E - mGlu1 receptor 4OR2 - -
ECL1 654 P - mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ECL1 655 Q - - - - -
TM3 656 D 3.26x26 mGlu5 receptor 6N51 - -
TM3 657 F 3.27x27 mGlu5 receptor 6N51 - -
TM3 658 T 3.28x28 mGlu5 receptor 6N51 - -
TM3 659 C 3.29x29 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 660 K 3.30x30 mGlu5 receptor 6N51 - -
TM3 661 T 3.31x31 mGlu5 receptor 6N51 - -
TM3 662 R 3.32x32 mGlu5 receptor 6N51 GABAB2 7C7Q
TM3 663 Q 3.33x33 mGlu5 receptor 6N51 - -
TM3 664 T 3.34x34 mGlu5 receptor 6N51 - -
TM3 665 M 3.35x35 mGlu5 receptor 6N51 - -
TM3 666 F 3.36x36 mGlu5 receptor 6N51 - -
TM3 667 G 3.37x37 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 668 V 3.38x38 mGlu5 receptor 6N51 GABAB2 7C7Q
TM3 669 S 3.39x39 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 670 F 3.40x40 mGlu5 receptor 6N51 GABAB1 6W2Y
TM3 671 T 3.41x41 mGlu5 receptor 6N51 GABAB2 7C7Q
TM3 672 L 3.42x42 mGlu5 receptor 6N51 GABAB1 6W2Y
TM3 673 C 3.43x43 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM3 674 I 3.44x44 mGlu5 receptor 6N51 - -
TM3 675 S 3.45x45 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 676 C 3.46x46 mGlu5 receptor 6N51 - -
TM3 677 I 3.47x47 mGlu5 receptor 6N51 - -
TM3 678 L 3.48x48 mGlu5 receptor 6N51 - -
TM3 679 T 3.49x49 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 680 K 3.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 681 S 3.51x51 mGlu5 receptor 6N51 - -
TM3 682 L 3.52x52 mGlu5 receptor 6N51 - -
TM3 683 K 3.53x53 mGlu5 receptor 6N51 - -
TM3 684 I 3.54x54 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 685 L 3.55x55 mGlu5 receptor 6N51 - -
TM3 686 L 3.56x56 mGlu5 receptor 6N51 - -
TM3 687 A 3.57x57 mGlu5 receptor 6N51 - -
TM3 688 F 3.58x58 mGlu5 receptor 6N51 GABAB2 7C7Q
TM3 689 S 3.59x59 GABAB2 7C7Q - -
ICL2 690 F - - - - -
ICL2 691 D - - - - -
ICL2 692 P - - - - -
ICL2 693 K - - - - -
ICL2 694 L - - - - -
ICL2 695 Q - - - - -
ICL2 696 K - - - - -
ICL2 697 F - - - - -
ICL2 698 L - - - - -
ICL2 699 K - - - - -
TM4 700 C 4.28x28 mGlu5 receptor 6N51 - -
TM4 701 L 4.29x29 mGlu5 receptor 6N51 - -
TM4 702 Y 4.30x30 mGlu5 receptor 6N51 - -
TM4 703 R 4.31x31 mGlu5 receptor 6N51 - -
TM4 704 P 4.32x32 mGlu5 receptor 6N51 - -
TM4 705 I 4.33x33 mGlu5 receptor 6N51 - -
TM4 706 L 4.34x34 mGlu5 receptor 6N51 - -
TM4 707 I 4.35x35 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 708 I 4.36x36 mGlu5 receptor 6N51 - -
TM4 709 F 4.37x37 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 710 T 4.38x38 mGlu5 receptor 6N51 - -
TM4 711 C 4.39x39 mGlu5 receptor 6N51 - -
TM4 712 T 4.40x40 mGlu5 receptor 6N51 - -
TM4 713 G 4.41x41 mGlu5 receptor 6N51 GABAB1 6W2Y
TM4 714 I 4.42x42 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 715 Q 4.43x43 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 716 V 4.44x44 mGlu5 receptor 6N51 - -
TM4 717 V 4.45x45 mGlu5 receptor 6N51 - -
TM4 718 I 4.46x46 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 719 C 4.47x47 mGlu5 receptor 6N51 - -
TM4 720 T 4.48x48 mGlu5 receptor 6N51 - -
TM4 721 L 4.49x49 mGlu5 receptor 6N51 - -
TM4 722 W 4.50x50 mGlu5 receptor 6N51 GABAB2 7C7Q
TM4 723 L 4.51x51 mGlu5 receptor 6N51 - -
TM4 724 I 4.52x52 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 725 F 4.53x53 mGlu5 receptor 6N51 - -
TM4 726 A 4.54x54 mGlu5 receptor 6N51 CaS receptor 7DTU
ECL2 727 A - mGlu5 receptor 6N51 - -
ECL2 728 P - mGlu5 receptor 6N51 mGlu5 receptor 6N51
ECL2 729 T - mGlu5 receptor 6N51 - -
ECL2 730 V - mGlu5 receptor 6N51 - -
ECL2 731 E - mGlu5 receptor 6N51 - -
ECL2 732 V - mGlu5 receptor 6N51 - -
ECL2 733 N - mGlu5 receptor 6N51 - -
ECL2 734 V - mGlu5 receptor 6N51 - -
ECL2 735 S - mGlu5 receptor 6N51 - -
ECL2 736 L - mGlu5 receptor 6N51 - -
ECL2 737 P - mGlu5 receptor 6N51 - -
ECL2 738 R - mGlu5 receptor 6N51 mGlu5 receptor 6N51
ECL2 739 V - mGlu5 receptor 6N51 - -
ECL2 740 I - mGlu5 receptor 6N51 - -
ECL2 741 I - mGlu5 receptor 6N51 - -
ECL2 742 L - mGlu5 receptor 6N51 mGlu5 receptor 6N51
ECL2 743 E - mGlu5 receptor 6N51 - -
ECL2 744 C 45.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
ECL2 745 E 45.51x51 mGlu5 receptor 6N51 GABAB2 7C7Q
ECL2 746 E 45.52x52 mGlu5 receptor 6N51 - -
ECL2 747 G - - - - -
ECL2 748 S - - - - -
TM5 749 I 5.37x37 mGlu5 receptor 6N51 - -
TM5 750 L 5.38x38 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 751 A 5.39x39 mGlu5 receptor 6N51 CaS receptor 7DTU
TM5 752 F 5.40x40 mGlu5 receptor 6N51 - -
TM5 753 G 5.41x41 mGlu5 receptor 6N51 GABAB2 7CA5
TM5 754 T 5.42x42 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 755 M 5.43x43 mGlu5 receptor 6N51 - -
TM5 756 L 5.44x44 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 757 G 5.45x45 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 758 Y 5.46x46 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM5 759 I 5.47x47 mGlu5 receptor 6N51 - -
TM5 760 A 5.48x48 mGlu5 receptor 6N51 - -
TM5 761 I 5.49x49 mGlu5 receptor 6N51 - -
TM5 762 L 5.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 763 A 5.51x51 mGlu5 receptor 6N51 CaS receptor 7DTU
TM5 764 F 5.52x52 mGlu5 receptor 6N51 - -
TM5 765 I 5.53x53 mGlu5 receptor 6N51 - -
TM5 766 C 5.54x54 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 767 F 5.55x55 mGlu5 receptor 6N51 - -
TM5 768 I 5.56x56 mGlu5 receptor 6N51 - -
TM5 769 F 5.57x57 mGlu5 receptor 6N51 - -
TM5 770 A 5.58x58 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 771 F 5.59x59 CaS receptor 7DTW mGlu1 receptor 4OR2
TM5 772 K 5.60x60 CaS receptor 7DTW mGlu5 receptor 6FFI
TM5 773 G 5.61x61 CaS receptor 7DTW - -
TM5 774 K 5.62x62 CaS receptor 7DTW - -
TM5 775 Y 5.63x63 CaS receptor 7DTW - -
TM5 776 E 5.64x64 CaS receptor 7DTW - -
ICL3 777 N - - - - -
ICL3 778 Y - - - - -
TM6 779 N 6.34x34 CaS receptor 7DTU mGlu5 receptor 6N51
TM6 780 E 6.35x35 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 781 A 6.36x36 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 782 K 6.37x37 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 783 F 6.38x38 mGlu5 receptor 6N51 - -
TM6 784 I 6.39x39 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM6 785 T 6.40x40 mGlu5 receptor 6N51 - -
TM6 786 F 6.41x41 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 787 G 6.42x42 mGlu5 receptor 6N51 - -
TM6 788 M 6.43x43 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 789 L 6.44x44 mGlu5 receptor 6N51 - -
TM6 790 I 6.45x45 mGlu5 receptor 6N51 - -
TM6 791 Y 6.46x46 mGlu5 receptor 6N51 - -
TM6 792 F 6.47x47 mGlu5 receptor 6N51 - -
TM6 793 I 6.48x48 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 794 A 6.49x49 mGlu5 receptor 6N51 - -
TM6 795 W 6.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 796 I 6.51x51 mGlu5 receptor 6N51 GABAB2 7C7Q
TM6 797 T 6.52x52 mGlu5 receptor 6N51 - -
TM6 798 F 6.53x53 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 799 I 6.54x54 mGlu5 receptor 6N51 - -
TM6 800 P 6.55x55 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 801 I 6.56x56 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 802 Y 6.57x57 mGlu5 receptor 6N51 CaS receptor 7DTV
TM6 803 A 6.58x58 mGlu5 receptor 6N51 CaS receptor 7DTU
TM6 804 T 6.59x59 mGlu5 receptor 6N51 - -
TM6 805 T 6.60x60 CaS receptor 7DTV CaS receptor 7DTV
ECL3 806 F - - - - -
TM7 807 G 7.25x26 CaS receptor 7DTU CaS receptor 7DTU
TM7 808 K 7.26x27 CaS receptor 7DTU CaS receptor 7DTV
TM7 809 Y 7.27x28 CaS receptor 7DTU mGlu1 receptor 4OR2
TM7 810 V 7.28x29 CaS receptor 7DTU CaS receptor 7DTV
TM7 811 P 7.29x30 mGlu5 receptor 6N51 - -
TM7 812 A 7.30x31 mGlu5 receptor 6N51 CaS receptor 7DTU
TM7 813 V 7.31x32 mGlu5 receptor 6N51 CaS receptor 7DTV
TM7 814 E 7.32x33 mGlu5 receptor 6N51 CaS receptor 7DTV
TM7 815 I 7.33x34 mGlu5 receptor 6N51 - -
TM7 816 I 7.34x35 mGlu5 receptor 6N51 - -
TM7 817 V 7.35x36 mGlu5 receptor 6N51 GABAB2 7C7Q
TM7 818 I 7.36x37 mGlu5 receptor 6N51 CaS receptor 7DTV
TM7 819 L 7.37x38 mGlu5 receptor 6N51 CaS receptor 7DTV
TM7 820 I 7.38x39 mGlu5 receptor 6N51 - -
TM7 821 S 7.39x40 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 822 N 7.40x41 mGlu5 receptor 6N51 - -
TM7 823 Y 7.41x42 mGlu5 receptor 6N51 GABAB1 6W2Y
TM7 824 G 7.42x43 mGlu5 receptor 6N51 CaS receptor 7DTU
TM7 825 I 7.43x44 mGlu5 receptor 6N51 - -
TM7 826 L 7.44x45 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 827 Y 7.45x46 mGlu5 receptor 6N51 - -
TM7 828 C 7.46x47 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 829 T 7.47x471 mGlu5 receptor 6N51 - -
TM7 830 F 7.48x48 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 831 I 7.49x49 mGlu5 receptor 6N51 - -
TM7 832 P 7.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 833 K 7.51x51 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 834 C 7.52x52 mGlu5 receptor 6N51 - -
TM7 835 Y 7.53x53 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 836 V 7.54x54 mGlu5 receptor 6N51 - -
TM7 837 I 7.55x55 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 838 I 7.56x56 mGlu5 receptor 6N51 - -
TM7 839 C 7.57x57 mGlu1 receptor 4OR2 - -
TM7 840 K 7.58x58 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
H8 841 Q 8.46x46 mGlu5 receptor 4OO9 - -
H8 842 E 8.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 843 I 8.48x48 mGlu5 receptor 4OO9 - -
H8 844 N 8.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 845 T 8.50x50 - - - -
H8 846 K 8.51x51 - - - -
H8 847 S 8.52x52 - - - -
H8 848 A 8.53x53 - - - -
H8 849 F 8.54x54 - - - -
H8 850 L 8.55x55 - - - -
H8 851 K 8.56x56 - - - -
H8 852 M 8.57x57 - - - -
C-term 853 I - - - - -
C-term 854 Y - - - - -
C-term 855 S - - - - -
C-term 856 Y - - - - -
C-term 857 S - - - - -