GPR12 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

GPR12

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-09-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

MC4 receptor (sequence similarity: 38%) PDB: 6W25
Align

TEMPLATES

6W25 (MC4 receptor)
7AUE (MC4 receptor)
7E2X (5-HT1A receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 82.3 5.3 12.4
Side-chains 29.7 49.8 20.5

Number of backbone templates: 3
Number of rotamer templates: 46

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 42 L - - - - -
N-term 43 V - MC4 receptor 6W25 MC4 receptor 6W25
N-term 44 V - MC4 receptor 6W25 MC4 receptor 6W25
N-term 45 N - MC4 receptor 6W25 MC4 receptor 6W25
N-term 46 P - MC4 receptor 6W25 MC4 receptor 6W25
TM1 47 W 1.35x35 MC4 receptor 6W25 - -
TM1 48 D 1.36x36 MC4 receptor 6W25 - -
TM1 49 I 1.37x37 MC4 receptor 6W25 M1 receptor 6WJC
TM1 50 V 1.38x38 MC4 receptor 6W25 MC4 receptor 6W25
TM1 51 L 1.39x39 MC4 receptor 6W25 5-HT1F receptor 7EXD
TM1 52 C 1.40x40 MC4 receptor 6W25 D3 receptor 7CMV
TM1 53 T 1.41x41 MC4 receptor 6W25 MC4 receptor 6W25
TM1 54 S 1.42x42 MC4 receptor 6W25 BLT1 receptor 5X33
TM1 55 G 1.43x43 MC4 receptor 6W25 MC4 receptor 6W25
TM1 56 T 1.44x44 MC4 receptor 6W25 CB1 receptor 5TGZ
TM1 57 L 1.45x45 MC4 receptor 6W25 GPR52 6LI1
TM1 58 I 1.46x46 MC4 receptor 6W25 GPR52 6LI0
TM1 59 S 1.47x47 MC4 receptor 6W25 US28 5WB1
TM1 60 C 1.48x48 MC4 receptor 6W25 - -
TM1 61 E 1.49x49 MC4 receptor 6W25 MC4 receptor 6W25
TM1 62 N 1.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM1 63 A 1.51x51 MC4 receptor 6W25 5-HT1B receptor 4IAQ
TM1 64 I 1.52x52 MC4 receptor 6W25 EP2 receptor 7CX2
TM1 65 V 1.53x53 MC4 receptor 6W25 MC4 receptor 6W25
TM1 66 V 1.54x54 MC4 receptor 6W25 5-HT1A receptor 7E2X
TM1 67 L 1.55x55 MC4 receptor 6W25 S1P1 receptor 3V2Y
TM1 68 I 1.56x56 MC4 receptor 6W25 CCR2 5T1A
TM1 69 I 1.57x57 MC4 receptor 6W25 MC4 receptor 6W25
TM1 70 F 1.58x58 MC4 receptor 6W25 α2A-adrenoceptor 6KUX
TM1 71 H 1.59x59 MC4 receptor 6W25 CB1 receptor 5TGZ
TM1 72 N 1.60x60 MC4 receptor 6W25 MC4 receptor 6W25
ICL1 73 P - MC4 receptor 6W25 - -
ICL1 74 S - MC4 receptor 6W25 - -
ICL1 75 L - MC4 receptor 6W25 MC4 receptor 6W25
ICL1 76 R - MC4 receptor 6W25 - -
TM2 77 A 2.37x37 MC4 receptor 6W25 α2A-adrenoceptor 6KUX
TM2 78 P 2.38x38 MC4 receptor 6W25 MC4 receptor 6W25
TM2 79 M 2.39x39 MC4 receptor 6W25 MC4 receptor 6W25
TM2 80 F 2.40x40 MC4 receptor 6W25 A1 receptor 5UEN
TM2 81 L 2.41x41 MC4 receptor 6W25 CB2 receptor 5ZTY
TM2 82 L 2.42x42 MC4 receptor 6W25 LPA1 receptor 4Z35
TM2 83 I 2.43x43 MC4 receptor 6W25 MC4 receptor 6W25
TM2 84 G 2.44x44 MC4 receptor 6W25 S1P1 receptor 3V2Y
TM2 85 S 2.45x45 MC4 receptor 6W25 MC4 receptor 6W25
TM2 86 L 2.46x46 MC4 receptor 6W25 MC4 receptor 6W25
TM2 87 A 2.47x47 MC4 receptor 6W25 MC4 receptor 6W25
TM2 88 L 2.48x48 MC4 receptor 6W25 S1P1 receptor 3V2Y
TM2 89 A 2.49x49 MC4 receptor 6W25 MC4 receptor 6W25
TM2 90 D 2.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM2 91 L 2.51x51 MC4 receptor 6W25 GPR52 6LI1
TM2 92 L 2.52x52 MC4 receptor 6W25 MC4 receptor 6W25
TM2 93 A 2.53x53 MC4 receptor 6W25 LPA1 receptor 4Z35
TM2 94 G 2.54x54 MC4 receptor 6W25 GPR52 6LI1
TM2 95 I 2.55x55 MC4 receptor 6W25 S1P3 receptor 7C4S
TM2 96 G 2.56x56 MC4 receptor 6W25 Rhodopsin 1U19
TM2 97 L 2.57x57 MC4 receptor 6W25 MC4 receptor 6W25
TM2 98 I 2.58x58 MC4 receptor 6W25 - -
TM2 99 T 2.59x59 MC4 receptor 6W25 Rhodopsin 1U19
TM2 100 N 2.60x60 MC4 receptor 6W25 S1P1 receptor 3V2Y
TM2 101 F 2.61x61 MC4 receptor 6W25 CB1 receptor 5TGZ
TM2 102 V 2.62x62 MC4 receptor 6W25 5-HT1F receptor 7EXD
ECL1 103 F - - - - -
ECL1 104 A 23.49x49 - - - -
ECL1 105 Y 23.50x50 - - - -
ECL1 106 L 23.51x51 - - - -
ECL1 107 L 23.52x52 - - - -
TM3 108 Q 3.20x20 MC4 receptor 6W25 - -
TM3 109 S 3.21x21 MC4 receptor 6W25 - -
TM3 110 E 3.22x22 MC4 receptor 6W25 MT2 receptor 6ME7
TM3 111 A 3.23x23 MC4 receptor 6W25 S1P1 receptor 3V2Y
TM3 112 T 3.24x24 MC4 receptor 6W25 GPR52 6LI1
TM3 113 K 3.25x25 MC4 receptor 6W25 - -
TM3 114 L 3.26x26 MC4 receptor 6W25 LPA1 receptor 4Z35
TM3 115 V 3.27x27 MC4 receptor 6W25 MC4 receptor 6W25
TM3 116 T 3.28x28 MC4 receptor 6W25 CCK1 receptor 7MBX
TM3 117 I 3.29x29 MC4 receptor 6W25 CB2 receptor 5ZTY
TM3 118 G 3.30x30 MC4 receptor 6W25 LPA1 receptor 4Z35
TM3 119 L 3.31x31 MC4 receptor 6W25 LPA1 receptor 4Z35
TM3 120 I 3.32x32 MC4 receptor 6W25 MC4 receptor 6W25
TM3 121 V 3.33x33 MC4 receptor 6W25 α2A-adrenoceptor 6KUX
TM3 122 A 3.34x34 MC4 receptor 6W25 MC4 receptor 6W25
TM3 123 S 3.35x35 MC4 receptor 6W25 MC4 receptor 6W25
TM3 124 F 3.36x36 MC4 receptor 6W25 CB1 receptor 5TGZ
TM3 125 S 3.37x37 MC4 receptor 6W25 GPR52 6LI1
TM3 126 A 3.38x38 MC4 receptor 6W25 MC4 receptor 6W25
TM3 127 S 3.39x39 MC4 receptor 6W25 MC4 receptor 6W25
TM3 128 V 3.40x40 MC4 receptor 6W25 LPA1 receptor 4Z35
TM3 129 C 3.41x41 MC4 receptor 6W25 MC4 receptor 6W25
TM3 130 S 3.42x42 MC4 receptor 6W25 MC4 receptor 6W25
TM3 131 L 3.43x43 MC4 receptor 6W25 MC4 receptor 6W25
TM3 132 L 3.44x44 MC4 receptor 6W25 MC4 receptor 6W25
TM3 133 A 3.45x45 MC4 receptor 6W25 LPA1 receptor 4Z35
TM3 134 I 3.46x46 MC4 receptor 6W25 MC4 receptor 6W25
TM3 135 T 3.47x47 MC4 receptor 6W25 CCR2 5T1A
TM3 136 V 3.48x48 MC4 receptor 6W25 MC4 receptor 6W25
TM3 137 D 3.49x49 MC4 receptor 6W25 MC4 receptor 6W25
TM3 138 R 3.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM3 139 Y 3.51x51 MC4 receptor 6W25 MC4 receptor 6W25
TM3 140 L 3.52x52 MC4 receptor 6W25 GPR52 6LI1
TM3 141 S 3.53x53 MC4 receptor 6W25 CB1 receptor 5TGZ
TM3 142 L 3.54x54 MC4 receptor 6W25 CB2 receptor 5ZTY
TM3 143 Y 3.55x55 MC4 receptor 6W25 - -
TM3 144 Y 3.56x56 MC4 receptor 6W25 MC4 receptor 6W25
ICL2 145 A 34.50x50 MC4 receptor 6W25 MC4 receptor 6W25
ICL2 146 L 34.51x51 MC4 receptor 6W25 MC4 receptor 6W25
ICL2 147 T 34.52x52 MC4 receptor 6W25 M5 receptor 6OL9
ICL2 148 Y 34.53x53 MC4 receptor 6W25 MC4 receptor 6W25
ICL2 149 H 34.54x54 MC4 receptor 6W25 MC4 receptor 6W25
ICL2 150 S 34.55x55 MC4 receptor 6W25 α2B-adrenoceptor 6K42
ICL2 151 E 34.56x56 MC4 receptor 6W25 - -
ICL2 152 R 34.57x57 MC4 receptor 6W25 5-HT1F receptor 7EXD
TM4 153 T 4.38x38 MC4 receptor 6W25 MC4 receptor 6W25
TM4 154 V 4.39x39 MC4 receptor 6W25 MC4 receptor 6W25
TM4 155 T 4.40x40 MC4 receptor 6W25 H1 receptor 3RZE
TM4 156 F 4.41x41 MC4 receptor 6W25 CCR2 5T1A
TM4 157 T 4.42x42 MC4 receptor 6W25 MT2 receptor 6ME7
TM4 158 Y 4.43x43 MC4 receptor 6W25 Y1 receptor 5ZBH
TM4 159 V 4.44x44 MC4 receptor 6W25 LPA1 receptor 4Z35
TM4 160 M 4.45x45 MC4 receptor 6W25 5-HT1F receptor 7EXD
TM4 161 L 4.46x46 MC4 receptor 6W25 CB2 receptor 5ZTY
TM4 162 V 4.47x47 MC4 receptor 6W25 LPA1 receptor 4Z35
TM4 163 M 4.48x48 MC4 receptor 6W25 S1P3 receptor 7C4S
TM4 164 L 4.49x49 MC4 receptor 6W25 apelin receptor 5VBL
TM4 165 W 4.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM4 166 G 4.51x51 MC4 receptor 6W25 CXCR2 6LFL
TM4 167 T 4.52x52 MC4 receptor 6W25 - -
TM4 168 S 4.53x53 MC4 receptor 6W25 GPR52 6LI1
TM4 169 I 4.54x54 MC4 receptor 6W25 LPA1 receptor 4Z35
TM4 170 C 4.55x55 MC4 receptor 6W25 5-HT1D receptor 7E32
TM4 171 L 4.56x56 MC4 receptor 6W25 S1P1 receptor 3V2Y
TM4 172 G 4.57x57 MC4 receptor 6W25 MC4 receptor 6W25
TM4 173 L 4.58x58 MC4 receptor 6W25 5-HT1B receptor 4IAQ
TM4 174 L 4.59x59 MC4 receptor 6W25 MC4 receptor 6W25
TM4 175 P 4.60x60 MC4 receptor 6W25 GPR52 6LI1
TM4 176 V 4.61x61 MC4 receptor 6W25 D1 receptor 7JVQ
TM4 177 M 4.62x62 MC4 receptor 6W25 CB2 receptor 5ZTY
TM4 178 G 4.63x63 MC4 receptor 6W25 LPA1 receptor 4Z35
TM4 179 W 4.64x64 MC4 receptor 6W25 5-HT1A receptor 7E2X
ECL2 180 N - - - - -
ECL2 181 C - - - - -
ECL2 182 L - - - - -
ECL2 183 R - - - - -
ECL2 184 D - - - - -
ECL2 185 E - - - - -
ECL2 186 S - - - - -
ECL2 187 T - - - - -
ECL2 188 C - - - - -
ECL2 189 S - - - - -
ECL2 190 V - - - - -
ECL2 191 V - - - - -
ECL2 192 R - - - - -
ECL2 193 P - - - - -
ECL2 194 L - - - - -
TM5 195 T 5.36x36 MC4 receptor 6W25 - -
TM5 196 K 5.37x37 MC4 receptor 6W25 S1P1 receptor 3V2Y
TM5 197 N 5.38x38 MC4 receptor 6W25 A2A receptor 4UHR
TM5 198 N 5.39x39 MC4 receptor 6W25 - -
TM5 199 A 5.40x40 MC4 receptor 6W25 D1 receptor 7JVQ
TM5 200 A 5.41x41 MC4 receptor 6W25 S1P3 receptor 7C4S
TM5 201 I 5.42x42 MC4 receptor 6W25 5-HT2C receptor 6BQH
TM5 202 L 5.43x43 MC4 receptor 6W25 MC4 receptor 6W25
TM5 203 S 5.44x44 MC4 receptor 6W25 D2 receptor 7JVR
TM5 204 V 5.45x45 MC4 receptor 6W25 GPR52 6LI1
TM5 205 S 5.46x46 MC4 receptor 6W25 PAF receptor 5ZKQ
TM5 206 F 5.47x47 MC4 receptor 6W25 MC4 receptor 6W25
TM5 207 L 5.48x48 MC4 receptor 6W25 LPA1 receptor 4Z35
TM5 208 F 5.49x49 MC4 receptor 6W25 CB2 receptor 5ZTY
TM5 209 M 5.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM5 210 F 5.51x51 MC4 receptor 6W25 LPA1 receptor 4Z35
TM5 211 A 5.52x52 MC4 receptor 6W25 MC4 receptor 6W25
TM5 212 L 5.53x53 MC4 receptor 6W25 MC4 receptor 6W25
TM5 213 M 5.54x54 MC4 receptor 6W25 MC4 receptor 6W25
TM5 214 L 5.55x55 MC4 receptor 6W25 5-HT1F receptor 7EXD
TM5 215 Q 5.56x56 MC4 receptor 6W25 - -
TM5 216 L 5.57x57 MC4 receptor 6W25 MC4 receptor 6W25
TM5 217 Y 5.58x58 MC4 receptor 6W25 MC4 receptor 6W25
TM5 218 I 5.59x59 MC4 receptor 6W25 D2 receptor 7JVR
TM5 219 Q 5.60x60 MC4 receptor 6W25 OX2 receptor 5WQC
TM5 220 I 5.61x61 MC4 receptor 6W25 LPA1 receptor 4Z35
TM5 221 C 5.62x62 MC4 receptor 6W25 EP4 receptor 5YWY
TM5 222 K 5.63x63 MC4 receptor 6W25 H1 receptor 3RZE
TM5 223 I 5.64x64 MC4 receptor 6W25 α2A-adrenoceptor 6KUX
TM5 224 V 5.65x65 MC4 receptor 7AUE LPA1 receptor 4Z35
TM5 225 M 5.66x66 MC4 receptor 7AUE EP2 receptor 7CX2
TM5 226 R 5.67x67 MC4 receptor 7AUE GPR52 6LI1
TM5 227 H 5.68x68 MC4 receptor 7AUE MC4 receptor 7AUE
TM5 228 A 5.69x69 MC4 receptor 7AUE CB1 receptor 6N4B
TM5 229 H 5.70x70 MC4 receptor 7AUE NTS1 receptor 4BUO
TM5 230 Q 5.71x71 MC4 receptor 7AUE A2A receptor 4UHR
TM5 231 I 5.72x72 MC4 receptor 7AUE MC4 receptor 7AUE
TM5 232 A 5.73x73 MC4 receptor 7AUE MC4 receptor 7AUE
ICL3 233 L - - - - -
ICL3 234 Q - - - - -
ICL3 235 H - - - - -
ICL3 236 H - - - - -
ICL3 237 F - - - - -
TM6 238 L 6.22x22 5-HT1A receptor 7E2X - -
TM6 239 A 6.23x23 5-HT1A receptor 7E2X A2A receptor 4UHR
TM6 240 T 6.24x24 5-HT1A receptor 7E2X - -
TM6 241 S 6.25x25 5-HT1A receptor 7E2X A2A receptor 4UHR
TM6 242 H 6.26x26 5-HT1A receptor 7E2X ETB receptor 5X93
TM6 243 Y 6.27x27 5-HT1A receptor 7E2X A1 receptor 6D9H
TM6 244 V 6.28x28 MC4 receptor 6W25 - -
TM6 245 T 6.29x29 MC4 receptor 6W25 LPA1 receptor 4Z35
TM6 246 T 6.30x30 MC4 receptor 6W25 Y1 receptor 5ZBH
TM6 247 R 6.31x31 MC4 receptor 6W25 GPR52 6LI1
TM6 248 K 6.32x32 MC4 receptor 6W25 MC4 receptor 6W25
TM6 249 G 6.33x33 MC4 receptor 6W25 MC4 receptor 6W25
TM6 250 V 6.34x34 MC4 receptor 6W25 5-HT1A receptor 7E2X
TM6 251 S 6.35x35 MC4 receptor 6W25 apelin receptor 5VBL
TM6 252 T 6.36x36 MC4 receptor 6W25 MC4 receptor 6W25
TM6 253 L 6.37x37 MC4 receptor 6W25 MC4 receptor 6W25
TM6 254 A 6.38x38 MC4 receptor 6W25 α2A-adrenoceptor 6KUX
TM6 255 I 6.39x39 MC4 receptor 6W25 MC4 receptor 6W25
TM6 256 I 6.40x40 MC4 receptor 6W25 GPR52 6LI1
TM6 257 L 6.41x41 MC4 receptor 6W25 LPA1 receptor 4Z35
TM6 258 G 6.42x42 MC4 receptor 6W25 MC4 receptor 6W25
TM6 259 T 6.43x43 MC4 receptor 6W25 5-HT1A receptor 7E2X
TM6 260 F 6.44x44 MC4 receptor 6W25 MC4 receptor 6W25
TM6 261 A 6.45x45 MC4 receptor 6W25 A2A receptor 4UHR
TM6 262 A 6.46x46 MC4 receptor 6W25 S1P1 receptor 3V2Y
TM6 263 C 6.47x47 MC4 receptor 6W25 MC4 receptor 6W25
TM6 264 W 6.48x48 MC4 receptor 6W25 MC4 receptor 6W25
TM6 265 M 6.49x49 MC4 receptor 6W25 CCK1 receptor 7MBX
TM6 266 P 6.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM6 267 F 6.51x51 MC4 receptor 6W25 MC4 receptor 6W25
TM6 268 T 6.52x52 MC4 receptor 6W25 Y1 receptor 5ZBH
TM6 269 L 6.53x53 MC4 receptor 6W25 MC4 receptor 6W25
TM6 270 Y 6.54x54 MC4 receptor 6W25 GPR52 6LI1
TM6 271 S 6.55x55 MC4 receptor 6W25 5-HT1B receptor 4IAQ
TM6 272 L 6.56x56 MC4 receptor 6W25 GPR52 6LI1
TM6 273 I 6.57x57 MC4 receptor 6W25 S1P3 receptor 7C4S
TM6 274 A 6.58x58 MC4 receptor 6W25 5-HT2A receptor 6A94
TM6 275 D 6.59x59 MC4 receptor 6W25 Y1 receptor 5ZBH
TM6 276 Y 6.60x60 MC4 receptor 6W25 CCK1 receptor 7MBX
TM6 277 T 6.61x61 MC4 receptor 6W25 CysLT2 receptor 6RZ6
ECL3 278 Y - - - - -
ECL3 279 P - - - - -
ECL3 280 S - - - - -
ECL3 281 I - - - - -
TM7 282 Y 7.34x33 MC4 receptor 6W25 M3 receptor 5ZHP
TM7 283 T 7.35x34 MC4 receptor 6W25 A1 receptor 5UEN
TM7 284 Y 7.36x35 MC4 receptor 6W25 A2A receptor 4UHR
TM7 285 A 7.37x36 MC4 receptor 6W25 D2 receptor 7JVR
TM7 286 T 7.38x37 MC4 receptor 6W25 GPR52 6LI1
TM7 287 L 7.39x38 MC4 receptor 6W25 MC4 receptor 6W25
TM7 288 L 7.40x39 MC4 receptor 6W25 LPA1 receptor 4Z35
TM7 289 P 7.41x40 MC4 receptor 6W25 - -
TM7 290 A 7.42x41 MC4 receptor 6W25 GPR52 6LI1
TM7 291 T 7.43x42 MC4 receptor 6W25 PAR2 5NDD
TM7 292 Y 7.44x43 MC4 receptor 6W25 - -
TM7 293 N 7.45x45 MC4 receptor 6W25 MC4 receptor 6W25
TM7 294 S 7.46x46 MC4 receptor 6W25 MC4 receptor 6W25
TM7 295 I 7.47x47 MC4 receptor 6W25 MC4 receptor 6W25
TM7 296 I 7.48x48 MC4 receptor 6W25 MC4 receptor 6W25
TM7 297 N 7.49x49 MC4 receptor 6W25 MC4 receptor 6W25
TM7 298 P 7.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM7 299 V 7.51x51 MC4 receptor 6W25 GPR52 6LI1
TM7 300 I 7.52x52 MC4 receptor 6W25 MC4 receptor 6W25
TM7 301 Y 7.53x53 MC4 receptor 6W25 MC4 receptor 6W25
TM7 302 A 7.54x54 MC4 receptor 6W25 MC4 receptor 6W25
TM7 303 F 7.55x55 MC4 receptor 6W25 D1 receptor 7JVQ
TM7 304 R 7.56x56 MC4 receptor 6W25 MC4 receptor 6W25
H8 305 N 8.47x47 MC4 receptor 6W25 S1P1 receptor 3V2Y
H8 306 Q 8.48x48 MC4 receptor 6W25 MC4 receptor 6W25
H8 307 E 8.49x49 MC4 receptor 6W25 MC4 receptor 6W25
H8 308 I 8.50x50 MC4 receptor 6W25 CB2 receptor 5ZTY
H8 309 Q 8.51x51 MC4 receptor 6W25 5-HT1A receptor 7E2X
H8 310 K 8.52x52 MC4 receptor 6W25 MC4 receptor 6W25
H8 311 A 8.53x53 MC4 receptor 6W25 S1P1 receptor 3V2Y
H8 312 L 8.54x54 MC4 receptor 6W25 GPR52 6LI1
H8 313 C 8.55x55 MC4 receptor 6W25 - -
H8 314 L 8.56x56 MC4 receptor 6W25 M1 receptor 6WJC
H8 315 I 8.57x57 MC4 receptor 6W25 MC4 receptor 6W25
H8 316 C 8.58x58 MC4 receptor 6W25 κ receptor 4DJH
H8 317 C 8.59x59 MC4 receptor 6W25 MC4 receptor 6W25
H8 318 G 8.60x60 MC4 receptor 6W25 - -
H8 319 C 8.61x61 MC4 receptor 6W25 OX2 receptor 5WQC
C-term 320 I - - - - -
C-term 321 P - - - - -
C-term 322 S - - - - -
C-term 323 S - - - - -
C-term 324 L - - - - -