GPR42 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

GPR42

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2022-06-19

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

PAR2 (sequence similarity: 35%) PDB: 5NDD
Align

TEMPLATES

5NDD (PAR2)
5VBL (apelin receptor)
5TZY (FFA1 receptor)
7TUZ (GPR183)
5LWE (CCR9)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 89.5 6.1 4.4
Side-chains 26.5 56.5 17.0

Number of backbone templates: 5
Number of rotamer templates: 50

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 6 D - PAR2 5NDD PAR2 5NDD
N-term 7 Q - PAR2 5NDD PAR2 5NDD
N-term 8 S - PAR2 5NDD PAR2 5NDD
N-term 9 Y - PAR2 5NDD PAR2 5NDD
N-term 10 F - PAR2 5NDD PAR2 5NDD
TM1 11 S 1.29x29 PAR2 5NDD GPR183 7TUZ
TM1 12 G 1.30x30 PAR2 5NDD NOP receptor 5DHG
TM1 13 N 1.31x31 PAR2 5NDD CXCR2 6LFL
TM1 14 H 1.32x32 PAR2 5NDD B1 receptor 7EIB
TM1 15 W 1.33x33 PAR2 5NDD CCR7 6QZH
TM1 16 F 1.34x34 PAR2 5NDD PAR2 5NDD
TM1 17 V 1.35x35 PAR2 5NDD CXCR2 6LFL
TM1 18 F 1.36x36 PAR2 5NDD - -
TM1 19 S 1.37x37 PAR2 5NDD - -
TM1 20 V 1.38x38 PAR2 5NDD PAR2 5NDD
TM1 21 Y 1.39x39 PAR2 5NDD PAR2 5NDD
TM1 22 L 1.40x40 PAR2 5NDD NOP receptor 5DHG
TM1 23 L 1.41x41 PAR2 5NDD GPR183 7TUZ
TM1 24 T 1.42x42 PAR2 5NDD FPR2/ALX 7WVX
TM1 25 F 1.43x43 PAR2 5NDD PAR2 5NDD
TM1 26 L 1.44x44 PAR2 5NDD CCK2 receptor 7F8W
TM1 27 V 1.45x45 PAR2 5NDD PAR2 5NDD
TM1 28 G 1.46x46 PAR2 5NDD GPR183 7TUZ
TM1 29 L 1.47x47 PAR2 5NDD PAR2 5NDD
TM1 30 P 1.48x48 PAR2 5NDD PAR2 5NDD
TM1 31 L 1.49x49 PAR2 5NDD H1 receptor 3RZE
TM1 32 N 1.50x50 PAR2 5NDD PAR2 5NDD
TM1 33 L 1.51x51 PAR2 5NDD GPR183 7TUZ
TM1 34 L 1.52x52 PAR2 5NDD GPR183 7TUZ
TM1 35 A 1.53x53 PAR2 5NDD PAR2 5NDD
TM1 36 L 1.54x54 PAR2 5NDD PAR2 5NDD
TM1 37 V 1.55x55 PAR2 5NDD GPR183 7TUZ
TM1 38 V 1.56x56 PAR2 5NDD PAR2 5NDD
TM1 39 F 1.57x57 PAR2 5NDD PAR2 5NDD
TM1 40 V 1.58x58 PAR2 5NDD GPR183 7TUZ
TM1 41 G 1.59x59 PAR2 5NDD - -
TM1 42 K 1.60x60 PAR2 5NDD NTS1 receptor 4XES
ICL1 43 L - - - - -
ICL1 44 R - apelin receptor 5VBL apelin receptor 5VBL
ICL1 45 C - apelin receptor 5VBL - -
ICL1 46 R - apelin receptor 5VBL - -
ICL1 47 P - - - - -
TM2 48 V 2.37x37 PAR2 5NDD - -
TM2 49 A 2.38x38 PAR2 5NDD CCR9 5LWE
TM2 50 V 2.39x39 PAR2 5NDD DP2 receptor 7M8W
TM2 51 D 2.40x40 PAR2 5NDD CCR7 6QZH
TM2 52 V 2.41x41 PAR2 5NDD AT1 receptor 4ZUD
TM2 53 L 2.42x42 PAR2 5NDD D3 receptor 7CMV
TM2 54 L 2.43x43 PAR2 5NDD CCR7 6QZH
TM2 55 L 2.44x44 PAR2 5NDD CCR7 6QZH
TM2 56 N 2.45x45 PAR2 5NDD PAR2 5NDD
TM2 57 L 2.46x46 PAR2 5NDD PAR2 5NDD
TM2 58 T 2.47x47 PAR2 5NDD GnRH1 receptor 7BR3
TM2 59 A 2.48x48 PAR2 5NDD US28 4XT1
TM2 60 S 2.49x49 PAR2 5NDD GPR183 7TUZ
TM2 61 D 2.50x50 PAR2 5NDD PAR2 5NDD
TM2 62 L 2.51x51 PAR2 5NDD PAR2 5NDD
TM2 63 L 2.52x52 PAR2 5NDD PAR2 5NDD
TM2 64 L 2.53x53 PAR2 5NDD CCK2 receptor 7F8W
TM2 65 L 2.54x54 PAR2 5NDD CCR7 6QZH
TM2 66 L 2.55x55 PAR2 5NDD CCR7 6QZH
TM2 67 F 2.56x56 PAR2 5NDD GPR139 7VUG
TM2 68 L 2.57x57 PAR2 5NDD GPR183 7TUZ
TM2 69 P 2.58x58 PAR2 5NDD PAR2 5NDD
TM2 70 F 2.59x59 PAR2 5NDD CCR7 6QZH
TM2 71 R 2.60x60 PAR2 5NDD GPR183 7TUZ
TM2 72 M 2.61x61 PAR2 5NDD US28 4XT1
TM2 73 V 2.62x62 PAR2 5NDD μ receptor 4DKL
TM2 74 E 2.63x63 PAR2 5NDD - -
TM2 75 A 2.64x64 PAR2 5NDD CCR7 6QZH
TM2 76 A 2.65x65 PAR2 5NDD CCR7 6QZH
TM2 77 N 2.66x66 PAR2 5NDD CXCR2 6LFO
ECL1 78 G - PAR2 5NDD PAR2 5NDD
ECL1 79 M - PAR2 5NDD - -
ECL1 80 H 23.49x49 PAR2 5NDD SST2 receptor 7T10
ECL1 81 W 23.50x50 PAR2 5NDD PAR2 5NDD
ECL1 82 P 23.51x51 PAR2 5NDD μ receptor 4DKL
ECL1 83 L 23.52x52 PAR2 5NDD GAL1 receptor 7WQ3
TM3 84 P 3.21x21 PAR2 5NDD 5-HT2C receptor 6BQH
TM3 85 F 3.22x22 PAR2 5NDD A1 receptor 5UEN
TM3 86 I 3.23x23 PAR2 5NDD μ receptor 4DKL
TM3 87 L 3.24x24 PAR2 5NDD PAR2 5NDD
TM3 88 C 3.25x25 PAR2 5NDD PAR2 5NDD
TM3 89 P 3.26x26 PAR2 5NDD 5-HT2C receptor 6BQH
TM3 90 L 3.27x27 PAR2 5NDD CCR7 6QZH
TM3 91 S 3.28x28 PAR2 5NDD apelin receptor 5VBL
TM3 92 G 3.29x29 PAR2 5NDD AT2 receptor 5UNG
TM3 93 F 3.30x30 PAR2 5NDD GAL2 receptor 7WQ4
TM3 94 I 3.31x31 PAR2 5NDD CCR7 6QZH
TM3 95 F 3.32x32 PAR2 5NDD PAR2 5NDD
TM3 96 F 3.33x33 PAR2 5NDD GAL2 receptor 7WQ4
TM3 97 T 3.34x34 PAR2 5NDD CCR1 7VL9
TM3 98 T 3.35x35 PAR2 5NDD GAL2 receptor 7WQ4
TM3 99 I 3.36x36 PAR2 5NDD GPR139 7VUG
TM3 100 Y 3.37x37 PAR2 5NDD PAR2 5NDD
TM3 101 L 3.38x38 PAR2 5NDD LH receptor 7FIG
TM3 102 T 3.39x39 PAR2 5NDD NTS1 receptor 4XES
TM3 103 A 3.40x40 PAR2 5NDD apelin receptor 5VBL
TM3 104 L 3.41x41 PAR2 5NDD PAR2 5NDD
TM3 105 F 3.42x42 PAR2 5NDD PAR2 5NDD
TM3 106 L 3.43x43 PAR2 5NDD CCR7 6QZH
TM3 107 A 3.44x44 PAR2 5NDD GAL1 receptor 7WQ3
TM3 108 A 3.45x45 PAR2 5NDD GAL1 receptor 7WQ3
TM3 109 V 3.46x46 PAR2 5NDD GAL2 receptor 7WQ4
TM3 110 S 3.47x47 PAR2 5NDD PAR2 5NDD
TM3 111 I 3.48x48 PAR2 5NDD GPR183 7TUZ
TM3 112 E 3.49x49 PAR2 5NDD CCK2 receptor 7F8W
TM3 113 R 3.50x50 PAR2 5NDD PAR2 5NDD
TM3 114 F 3.51x51 PAR2 5NDD GPR183 7TUZ
TM3 115 L 3.52x52 PAR2 5NDD SST2 receptor 7T10
TM3 116 S 3.53x53 PAR2 5NDD AT2 receptor 5UNG
TM3 117 V 3.54x54 PAR2 5NDD GPR183 7TUZ
TM3 118 A 3.55x55 PAR2 5NDD CCR9 5LWE
TM3 119 H 3.56x56 PAR2 5NDD μ receptor 4DKL
ICL2 120 P 34.50x50 - - - -
ICL2 121 L 34.51x51 FFA1 receptor 5TZY FFA1 receptor 5TZY
ICL2 122 W 34.52x52 FFA1 receptor 5TZY DP2 receptor 7M8W
ICL2 123 Y 34.53x53 FFA1 receptor 5TZY FFA1 receptor 5TZY
ICL2 124 K 34.54x54 FFA1 receptor 5TZY ghrelin receptor 7NA7
ICL2 125 T 34.55x55 FFA1 receptor 5TZY CCR9 5LWE
ICL2 126 R 34.56x56 FFA1 receptor 5TZY AT1 receptor 6DO1
ICL2 127 P 34.57x57 - - - -
TM4 128 R 4.38x38 PAR2 5NDD CCR9 5LWE
TM4 129 L 4.39x39 PAR2 5NDD CCR7 6QZH
TM4 130 G 4.40x40 PAR2 5NDD ghrelin receptor 7NA7
TM4 131 Q 4.41x41 PAR2 5NDD US28 4XT1
TM4 132 A 4.42x42 PAR2 5NDD PAR2 5NDD
TM4 133 G 4.43x43 PAR2 5NDD M2 receptor 5YC8
TM4 134 L 4.44x44 PAR2 5NDD CCR7 6QZH
TM4 135 V 4.45x45 PAR2 5NDD GPR183 7TUZ
TM4 136 S 4.46x46 PAR2 5NDD PAR2 5NDD
TM4 137 V 4.47x47 PAR2 5NDD CCR7 6QZH
TM4 138 A 4.48x48 PAR2 5NDD PAR2 5NDD
TM4 139 C 4.49x49 PAR2 5NDD A2A receptor 4UHR
TM4 140 W 4.50x50 PAR2 5NDD PAR2 5NDD
TM4 141 L 4.51x51 PAR2 5NDD PAR2 5NDD
TM4 142 L 4.52x52 PAR2 5NDD PAR2 5NDD
TM4 143 A 4.53x53 PAR2 5NDD CCR7 6QZH
TM4 144 S 4.54x54 PAR2 5NDD μ receptor 4DKL
TM4 145 A 4.55x55 PAR2 5NDD GPR183 7TUZ
TM4 146 H 4.56x56 PAR2 5NDD - -
TM4 147 C 4.57x57 FFA1 receptor 5TZY CCR9 5LWE
TM4 148 S 4.58x58 FFA1 receptor 5TZY EP2 receptor 7CX2
TM4 149 V 4.59x59 FFA1 receptor 5TZY CCK2 receptor 7F8W
TM4 150 V 4.60x60 PAR2 5NDD μ receptor 4DKL
TM4 151 Y 4.61x61 PAR2 5NDD CCK2 receptor 7F8W
TM4 152 V 4.62x62 PAR2 5NDD κ receptor 4DJH
TM4 153 I 4.63x63 PAR2 5NDD GPR183 7TUZ
ECL2 154 E - PAR2 5NDD - -
ECL2 155 F - PAR2 5NDD - -
ECL2 156 S - PAR2 5NDD - -
ECL2 157 G - PAR2 5NDD - -
ECL2 158 D - PAR2 5NDD - -
ECL2 159 I - PAR2 5NDD - -
ECL2 160 S - PAR2 5NDD - -
ECL2 161 H - PAR2 5NDD - -
ECL2 162 S - PAR2 5NDD - -
ECL2 163 Q - PAR2 5NDD - -
ECL2 164 G - PAR2 5NDD - -
ECL2 165 T - PAR2 5NDD - -
ECL2 166 N - PAR2 5NDD - -
ECL2 167 G - PAR2 5NDD - -
ECL2 168 T - - - - -
ECL2 169 C 45.50x50 PAR2 5NDD PAR2 5NDD
ECL2 170 Y 45.51x51 PAR2 5NDD - -
ECL2 171 L 45.52x52 PAR2 5NDD μ receptor 7U2L
ECL2 172 E - PAR2 5NDD - -
ECL2 173 F - PAR2 5NDD - -
ECL2 174 W - PAR2 5NDD - -
ECL2 175 K - PAR2 5NDD - -
ECL2 176 D - PAR2 5NDD - -
ECL2 177 Q - PAR2 5NDD PAR2 5NDD
TM5 178 L 5.32x33 PAR2 5NDD B2 receptor 7F2O
TM5 179 A 5.33x34 PAR2 5NDD SST2 receptor 7T10
TM5 180 I 5.34x35 PAR2 5NDD - -
TM5 181 L 5.35x36 PAR2 5NDD GPR183 7TUZ
TM5 182 L 5.36x37 PAR2 5NDD κ receptor 4DJH
TM5 183 P 5.37x38 PAR2 5NDD β3-adrenoceptor 7DH5
TM5 184 V 5.38x39 PAR2 5NDD NTS1 receptor 4XES
TM5 185 R 5.39x40 PAR2 5NDD CXCR2 6LFO
TM5 186 L 5.40x41 PAR2 5NDD PAR2 5NDD
TM5 187 E 5.41x42 PAR2 5NDD US28 4XT1
TM5 188 M 5.42x43 PAR2 5NDD Rhodopsin 1U19
TM5 189 A 5.43x44 PAR2 5NDD PAR2 5NDD
TM5 190 V 5.44x45 PAR2 5NDD CCR7 6QZH
TM5 191 V 5.45x46 PAR2 5NDD CXCR4 3ODU
TM5 192 L 5.46x461 PAR2 5NDD CCK2 receptor 7F8W
TM5 193 F 5.47x47 PAR2 5NDD PAR2 5NDD
TM5 194 V 5.48x48 PAR2 5NDD GPR183 7TUZ
TM5 195 V 5.49x49 PAR2 5NDD CCR7 6QZH
TM5 196 P 5.50x50 PAR2 5NDD PAR2 5NDD
TM5 197 L 5.51x51 PAR2 5NDD GPR183 7TUZ
TM5 198 I 5.52x52 PAR2 5NDD GPR183 7TUZ
TM5 199 I 5.53x53 PAR2 5NDD GPR183 7TUZ
TM5 200 T 5.54x54 PAR2 5NDD PAR2 5NDD
TM5 201 S 5.55x55 PAR2 5NDD CCR7 6QZH
TM5 202 Y 5.56x56 PAR2 5NDD US28 4XT1
TM5 203 C 5.57x57 PAR2 5NDD GPR183 7TUZ
TM5 204 Y 5.58x58 PAR2 5NDD PAR2 5NDD
TM5 205 S 5.59x59 PAR2 5NDD GPR183 7TUZ
TM5 206 R 5.60x60 PAR2 5NDD US28 4XT1
TM5 207 L 5.61x61 PAR2 5NDD Rhodopsin 4X1H
TM5 208 V 5.62x62 PAR2 5NDD CCR6 6WWZ
TM5 209 W 5.63x63 PAR2 5NDD CB1 receptor 5TGZ
TM5 210 I 5.64x64 PAR2 5NDD CCR1 7VL9
TM5 211 L 5.65x65 PAR2 5NDD PAR2 5NDD
TM5 212 G 5.66x66 GPR183 7TUZ - -
TM5 213 R 5.67x67 GPR183 7TUZ GPR183 7TUZ
TM5 214 G 5.68x68 GPR183 7TUZ CCK2 receptor 7F8W
ICL3 215 G - - - - -
ICL3 216 S - - - - -
ICL3 217 H - - - - -
TM6 218 R 6.28x29 PAR2 5NDD CCR2 5T1A
TM6 219 R 6.29x30 PAR2 5NDD AT2 receptor 5UNG
TM6 220 Q 6.30x31 PAR2 5NDD 5-HT2A receptor 6A94
TM6 221 R 6.31x32 PAR2 5NDD μ receptor 4DKL
TM6 222 R 6.32x33 PAR2 5NDD PAR2 5NDD
TM6 223 V 6.33x34 PAR2 5NDD CCR1 7VL9
TM6 224 A 6.34x35 PAR2 5NDD B1 receptor 7EIB
TM6 225 G 6.35x36 PAR2 5NDD - -
TM6 226 L 6.36x37 PAR2 5NDD PAR2 5NDD
TM6 227 V 6.37x38 PAR2 5NDD CXCR4 3ODU
TM6 228 A 6.38x39 PAR2 5NDD CCR7 6QZH
TM6 229 A 6.39x40 PAR2 5NDD GPBA receptor 7CFN
TM6 230 T 6.40x41 PAR2 5NDD GPR139 7VUG
TM6 231 L 6.41x42 PAR2 5NDD AT1 receptor 4ZUD
TM6 232 L 6.42x43 PAR2 5NDD CCK2 receptor 7F8W
TM6 233 N 6.43x44 PAR2 5NDD - -
TM6 234 F 6.44x45 PAR2 5NDD CCR1 7VL9
TM6 235 L 6.45x46 PAR2 5NDD PAR2 5NDD
TM6 236 V 6.46x461 PAR2 5NDD - -
TM6 237 C 6.47x47 PAR2 5NDD PAR2 5NDD
TM6 238 F 6.48x48 PAR2 5NDD PAR2 5NDD
TM6 239 G 6.49x49 PAR2 5NDD DP2 receptor 7M8W
TM6 240 P 6.50x50 PAR2 5NDD PAR2 5NDD
TM6 241 Y 6.51x51 PAR2 5NDD GPR183 7TUZ
TM6 242 N 6.52x52 PAR2 5NDD PAR2 5NDD
TM6 243 V 6.53x53 PAR2 5NDD GPR183 7TUZ
TM6 244 S 6.54x54 PAR2 5NDD B2 receptor 7F2O
TM6 245 H 6.55x55 PAR2 5NDD GAL1 receptor 7WQ3
TM6 246 V 6.56x56 PAR2 5NDD PAR2 5NDD
TM6 247 V 6.57x57 PAR2 5NDD PAR2 5NDD
TM6 248 G 6.58x58 PAR2 5NDD FPR2/ALX 7WVX
TM6 249 Y 6.59x59 PAR2 5NDD PAR2 5NDD
TM6 250 I 6.60x60 PAR2 5NDD GPR183 7TUZ
TM6 251 C 6.61x61 PAR2 5NDD D2 receptor 7JVR
ECL3 252 G - PAR2 5NDD PAR2 5NDD
ECL3 253 E - PAR2 5NDD - -
ECL3 254 S - PAR2 5NDD PAR2 5NDD
ECL3 255 P - PAR2 5NDD - -
TM7 256 V 7.33x32 PAR2 5NDD μ receptor 4DKL
TM7 257 W 7.34x33 PAR2 5NDD CXCR4 3ODU
TM7 258 R 7.35x34 PAR2 5NDD GAL1 receptor 7WQ3
TM7 259 I 7.36x35 PAR2 5NDD PAR2 5NDD
TM7 260 Y 7.37x36 PAR2 5NDD apelin receptor 5VBL
TM7 261 V 7.38x37 PAR2 5NDD SST2 receptor 7T10
TM7 262 T 7.39x38 PAR2 5NDD NOP receptor 5DHG
TM7 263 L 7.40x39 PAR2 5NDD CCK2 receptor 7F8W
TM7 264 L 7.41x40 PAR2 5NDD PAR2 5NDD
TM7 265 S 7.42x41 PAR2 5NDD PAR2 5NDD
TM7 266 T 7.43x42 PAR2 5NDD PAR2 5NDD
TM7 267 L 7.44x43 PAR2 5NDD PAR2 5NDD
TM7 268 N 7.45x45 PAR2 5NDD PAR2 5NDD
TM7 269 S 7.46x46 PAR2 5NDD PAR2 5NDD
TM7 270 C 7.47x47 PAR2 5NDD PAR2 5NDD
TM7 271 V 7.48x48 PAR2 5NDD CCR7 6QZH
TM7 272 D 7.49x49 PAR2 5NDD PAR2 5NDD
TM7 273 P 7.50x50 PAR2 5NDD PAR2 5NDD
TM7 274 F 7.51x51 PAR2 5NDD PAR2 5NDD
TM7 275 V 7.52x52 PAR2 5NDD PAR2 5NDD
TM7 276 Y 7.53x53 PAR2 5NDD PAR2 5NDD
TM7 277 Y 7.54x54 PAR2 5NDD PAR2 5NDD
TM7 278 F 7.55x55 PAR2 5NDD PAR2 5NDD
TM7 279 S 7.56x56 PAR2 5NDD 5-HT1B receptor 4IAQ
H8 280 S 8.47x47 PAR2 5NDD PAR2 5NDD
H8 281 S 8.48x48 PAR2 5NDD Y2 receptor 7DDZ
H8 282 G 8.49x49 PAR2 5NDD - -
H8 283 F 8.50x50 PAR2 5NDD PAR2 5NDD
H8 284 Q 8.51x51 PAR2 5NDD AT2 receptor 5UNF
H8 285 A 8.52x52 PAR2 5NDD NOP receptor 5DHG
H8 286 D 8.53x53 PAR2 5NDD CCR7 6QZH
H8 287 F 8.54x54 PAR2 5NDD μ receptor 4DKL
H8 288 H 8.55x55 PAR2 5NDD US28 4XT1
H8 289 E 8.56x56 PAR2 5NDD CCK2 receptor 7F8W
H8 290 L 8.57x57 PAR2 5NDD CCR1 7VL9
H8 291 L 8.58x58 PAR2 5NDD PAR2 5NDD
H8 292 R 8.59x59 CCR9 5LWE DP2 receptor 7M8W
H8 293 R 8.60x60 CCR9 5LWE CCR1 7VL9
H8 294 L 8.61x61 CCR9 5LWE CCR9 5LWE
C-term 295 C - - - - -
C-term 296 G - - - - -
C-term 297 L - - - - -
C-term 298 W - - - - -
C-term 299 G - - - - -