GPR88 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

GPR88

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2022-06-19

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

MC4 receptor (sequence similarity: 25%) PDB: 6W25
Align

TEMPLATES

4N6H (δ receptor)
6W25 (MC4 receptor)
7EJX (GPR88)
7F4H (MC1 receptor)
6LI0 (GPR52)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 69.6 13.9 16.6
Side-chains 12.5 66.9 20.6

Number of backbone templates: 5
Number of rotamer templates: 19

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 18 L - - - - -
N-term 19 L - - - - -
N-term 20 L - - - - -
N-term 21 C - - - - -
N-term 22 E - - - - -
TM1 23 E 1.24x24 δ receptor 4N6H - -
TM1 24 E 1.25x25 δ receptor 4N6H CXCR4 4RWS
TM1 25 E 1.26x26 δ receptor 4N6H CCR6 6WWZ
TM1 26 S 1.27x27 δ receptor 4N6H δ receptor 4N6H
TM1 27 W 1.28x28 δ receptor 4N6H B1 receptor 7EIB
TM1 28 A 1.29x29 δ receptor 4N6H α2C-adrenoceptor 6KUW
TM1 29 G 1.30x30 δ receptor 4N6H α2C-adrenoceptor 6KUW
TM1 30 R 1.31x31 δ receptor 4N6H - -
TM1 31 R 1.32x32 δ receptor 4N6H D1 receptor 7JVQ
TM1 32 I 1.33x33 δ receptor 4N6H δ receptor 4N6H
TM1 33 P 1.34x34 δ receptor 4N6H H1 receptor 7DFL
TM1 34 V 1.35x35 MC4 receptor 6W25 - -
TM1 35 S 1.36x36 MC4 receptor 6W25 MT2 receptor 6ME7
TM1 36 L 1.37x37 MC4 receptor 6W25 β1-adrenoceptor 7BVQ
TM1 37 L 1.38x38 MC4 receptor 6W25 GPR88 7EJX
TM1 38 Y 1.39x39 MC4 receptor 6W25 GPR88 7EJX
TM1 39 S 1.40x40 MC4 receptor 6W25 GPR88 7EJX
TM1 40 G 1.41x41 MC4 receptor 6W25 GPR88 7EJX
TM1 41 L 1.42x42 MC4 receptor 6W25 MC4 receptor 6W25
TM1 42 A 1.43x43 MC4 receptor 6W25 GPR88 7EJX
TM1 43 I 1.44x44 MC4 receptor 6W25 GPR88 7EJX
TM1 44 G 1.45x45 MC4 receptor 6W25 GPR88 7EJX
TM1 45 G 1.46x46 MC4 receptor 6W25 GPR88 7EJX
TM1 46 T 1.47x47 MC4 receptor 6W25 GPR88 7EJX
TM1 47 L 1.48x48 MC4 receptor 6W25 MC4 receptor 6W25
TM1 48 A 1.49x49 MC4 receptor 6W25 GPR88 7EJX
TM1 49 N 1.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM1 50 G 1.51x51 MC4 receptor 6W25 GPR88 7EJX
TM1 51 M 1.52x52 MC4 receptor 6W25 GPR88 7EJX
TM1 52 V 1.53x53 MC4 receptor 6W25 MC4 receptor 6W25
TM1 53 I 1.54x54 MC4 receptor 6W25 MC4 receptor 6W25
TM1 54 Y 1.55x55 MC4 receptor 6W25 GPR88 7EJX
TM1 55 L 1.56x56 MC4 receptor 6W25 GPR88 7EJX
TM1 56 V 1.57x57 MC4 receptor 6W25 GPR88 7EJX
TM1 57 S 1.58x58 MC4 receptor 6W25 GPR88 7EJX
TM1 58 S 1.59x59 MC4 receptor 6W25 GPR88 7EJX
TM1 59 F 1.60x60 MC4 receptor 6W25 GPR88 7EJX
ICL1 60 R 12.48x48 - - - -
ICL1 61 K 12.49x49 GPR88 7EJX GPR88 7EJX
ICL1 62 L 12.50x50 GPR88 7EJX GPR88 7EJX
ICL1 63 Q 12.51x51 - - - -
TM2 64 T 2.37x37 MC4 receptor 6W25 GPR88 7EJX
TM2 65 T 2.38x38 MC4 receptor 6W25 GPR88 7EJX
TM2 66 S 2.39x39 MC4 receptor 6W25 GPR88 7EJX
TM2 67 N 2.40x40 MC4 receptor 6W25 GPR88 7EJX
TM2 68 A 2.41x41 MC4 receptor 6W25 GPR88 7EJX
TM2 69 F 2.42x42 MC4 receptor 6W25 MC4 receptor 6W25
TM2 70 I 2.43x43 MC4 receptor 6W25 MC4 receptor 6W25
TM2 71 V 2.44x44 MC4 receptor 6W25 GPR88 7EJX
TM2 72 N 2.45x45 MC4 receptor 6W25 GPR88 7EJX
TM2 73 G 2.46x46 MC4 receptor 6W25 GPR88 7EJX
TM2 74 C 2.47x47 MC4 receptor 6W25 GPR88 7EJX
TM2 75 A 2.48x48 MC4 receptor 6W25 GPR88 7EJX
TM2 76 A 2.49x49 MC4 receptor 6W25 MC4 receptor 6W25
TM2 77 D 2.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM2 78 L 2.51x51 MC4 receptor 6W25 GPR88 7EJX
TM2 79 S 2.52x52 MC4 receptor 6W25 GPR88 7EJX
TM2 80 V 2.53x53 MC4 receptor 6W25 MC4 receptor 6W25
TM2 81 C 2.54x54 MC4 receptor 6W25 GPR88 7EJX
TM2 82 A 2.55x55 GPR88 7EJX GPR88 7EJX
TM2 83 L 2.56x551 GPR88 7EJX GPR88 7EJX
TM2 84 W 2.57x56 GPR88 7EJX GPR88 7EJX
TM2 85 M 2.58x57 MC4 receptor 6W25 D1 receptor 7JVQ
TM2 86 P 2.59x58 MC4 receptor 6W25 β1-adrenoceptor 7BVQ
TM2 87 Q 2.60x59 MC4 receptor 6W25 - -
TM2 88 E 2.61x60 MC4 receptor 6W25 MC4 receptor 6W25
TM2 89 A 2.62x61 MC4 receptor 6W25 β1-adrenoceptor 7BVQ
TM2 90 V 2.63x62 MC4 receptor 6W25 D1 receptor 7JVQ
TM2 91 L 2.64x63 MC4 receptor 6W25 D2 receptor 7JVR
TM2 92 G 2.65x64 MC4 receptor 6W25 - -
TM2 93 L 2.66x65 MC4 receptor 6W25 β2-adrenoceptor 3SN6
TM2 94 L 2.67x66 MC4 receptor 6W25 MC4 receptor 6W25
TM2 95 P 2.68x67 MC4 receptor 6W25 - -
ECL1 96 T - - - - -
ECL1 97 G - - - - -
ECL1 98 S - - - - -
ECL1 99 A - - - - -
ECL1 100 E - - - - -
ECL1 101 P - - - - -
ECL1 102 P - - - - -
ECL1 103 A - - - - -
ECL1 104 D - - - - -
ECL1 105 W - - - - -
TM3 106 D 3.18x18 MC1 receptor 7F4H - -
TM3 107 G 3.19x19 MC4 receptor 6W25 - -
TM3 108 A 3.20x20 MC4 receptor 6W25 - -
TM3 109 G 3.21x21 MC4 receptor 6W25 ghrelin receptor 7F83
TM3 110 G 3.22x22 MC4 receptor 6W25 D1 receptor 7JVQ
TM3 111 S 3.23x23 MC4 receptor 6W25 D1 receptor 7JVQ
TM3 112 Y 3.24x24 MC4 receptor 6W25 NK1 receptor 6HLP
TM3 113 R 3.25x25 MC4 receptor 6W25 MRGPRX4 7S8P
TM3 114 L 3.26x26 MC4 receptor 6W25 GPR88 7EJX
TM3 115 L 3.27x27 MC4 receptor 6W25 GPR88 7EJX
TM3 116 R 3.28x28 MC4 receptor 6W25 GPR88 7EJX
TM3 117 G 3.29x29 MC4 receptor 6W25 GPR88 7EJX
TM3 118 G 3.30x30 MC4 receptor 6W25 GPR88 7EJX
TM3 119 L 3.31x31 MC4 receptor 6W25 GPR88 7EJX
TM3 120 L 3.32x32 MC4 receptor 6W25 GPR88 7EJX
TM3 121 G 3.33x33 MC4 receptor 6W25 GPR88 7EJX
TM3 122 L 3.34x34 MC4 receptor 6W25 GPR88 7EJX
TM3 123 G 3.35x35 MC4 receptor 6W25 GPR88 7EJX
TM3 124 L 3.36x36 MC4 receptor 6W25 MC4 receptor 6W25
TM3 125 T 3.37x37 MC4 receptor 6W25 GPR88 7EJX
TM3 126 V 3.38x38 MC4 receptor 6W25 GPR88 7EJX
TM3 127 S 3.39x39 MC4 receptor 6W25 MC4 receptor 6W25
TM3 128 L 3.40x40 MC4 receptor 6W25 GPR88 7EJX
TM3 129 L 3.41x41 MC4 receptor 6W25 GPR88 7EJX
TM3 130 S 3.42x42 MC4 receptor 6W25 MC4 receptor 6W25
TM3 131 H 3.43x43 MC4 receptor 6W25 GPR88 7EJX
TM3 132 C 3.44x44 MC4 receptor 6W25 GPR88 7EJX
TM3 133 L 3.45x45 MC4 receptor 6W25 GPR88 7EJX
TM3 134 V 3.46x46 MC4 receptor 6W25 GPR88 7EJX
TM3 135 A 3.47x47 MC4 receptor 6W25 MC4 receptor 6W25
TM3 136 L 3.48x48 MC4 receptor 6W25 GPR88 7EJX
TM3 137 N 3.49x49 MC4 receptor 6W25 GPR88 7EJX
TM3 138 R 3.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM3 139 Y 3.51x51 MC4 receptor 6W25 MC4 receptor 6W25
TM3 140 L 3.52x52 MC4 receptor 6W25 GPR88 7EJX
TM3 141 L 3.53x53 MC4 receptor 6W25 GPR88 7EJX
TM3 142 I 3.54x54 MC4 receptor 6W25 MC4 receptor 6W25
TM3 143 T 3.55x55 MC4 receptor 6W25 GPR88 7EJX
TM3 144 R 3.56x56 MC4 receptor 6W25 GPR88 7EJX
ICL2 145 A - - - - -
ICL2 146 P 34.50x50 GPR88 7EJX GPR88 7EJX
ICL2 147 A 34.51x51 GPR88 7EJX GPR88 7EJX
ICL2 148 T 34.52x52 GPR88 7EJX GPR88 7EJX
ICL2 149 Y 34.53x53 GPR88 7EJX GPR88 7EJX
ICL2 150 Q 34.54x54 GPR88 7EJX GPR88 7EJX
ICL2 151 A 34.55x55 GPR88 7EJX GPR88 7EJX
ICL2 152 L 34.56x56 GPR88 7EJX GPR88 7EJX
ICL2 153 Y 34.57x57 - - - -
TM4 154 Q 4.38x38 MC4 receptor 6W25 GPR88 7EJX
TM4 155 R 4.39x39 MC4 receptor 6W25 GPR88 7EJX
TM4 156 R 4.40x40 MC4 receptor 6W25 GPR88 7EJX
TM4 157 H 4.41x41 MC4 receptor 6W25 GPR88 7EJX
TM4 158 T 4.42x42 MC4 receptor 6W25 GPR88 7EJX
TM4 159 A 4.43x43 MC4 receptor 6W25 GPR88 7EJX
TM4 160 G 4.44x44 MC4 receptor 6W25 GPR88 7EJX
TM4 161 M 4.45x45 MC4 receptor 6W25 GPR88 7EJX
TM4 162 L 4.46x46 MC4 receptor 6W25 GPR88 7EJX
TM4 163 A 4.47x47 MC4 receptor 6W25 GPR88 7EJX
TM4 164 L 4.48x48 MC4 receptor 6W25 GPR88 7EJX
TM4 165 S 4.49x49 MC4 receptor 6W25 GPR88 7EJX
TM4 166 W 4.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM4 167 A 4.51x51 MC4 receptor 6W25 MC4 receptor 6W25
TM4 168 L 4.52x52 MC4 receptor 6W25 GPR88 7EJX
TM4 169 A 4.53x53 MC4 receptor 6W25 GPR88 7EJX
TM4 170 L 4.54x54 MC4 receptor 6W25 GPR88 7EJX
TM4 171 G 4.55x55 MC4 receptor 6W25 GPR88 7EJX
TM4 172 L 4.56x56 MC4 receptor 6W25 GPR88 7EJX
TM4 173 V 4.57x57 MC4 receptor 6W25 GPR88 7EJX
TM4 174 L 4.58x58 MC4 receptor 6W25 GPR88 7EJX
TM4 175 L 4.59x59 MC4 receptor 6W25 MC4 receptor 6W25
TM4 176 L 4.60x60 MC4 receptor 6W25 BILF1 7JHJ
ECL2 177 P - - - - -
ECL2 178 P - - - - -
ECL2 179 W - - - - -
ECL2 180 A - - - - -
ECL2 181 P - - - - -
ECL2 182 R - - - - -
ECL2 183 P - - - - -
ECL2 184 G - - - - -
ECL2 185 A - - - - -
ECL2 186 A - - - - -
ECL2 187 P - - - - -
ECL2 188 P - - - - -
TM5 189 R 5.35x36 MC4 receptor 6W25 - -
TM5 190 V 5.36x37 MC4 receptor 6W25 5-HT1E receptor 7E33
TM5 191 H 5.37x38 MC4 receptor 6W25 S1P1 receptor 7TD4
TM5 192 Y 5.38x39 MC4 receptor 6W25 β1-adrenoceptor 7BVQ
TM5 193 P 5.39x40 MC4 receptor 6W25 GPR88 7EJX
TM5 194 A 5.40x41 MC4 receptor 6W25 GPR88 7EJX
TM5 195 L 5.41x42 MC4 receptor 6W25 GPR88 7EJX
TM5 196 L 5.42x43 MC4 receptor 6W25 MC4 receptor 6W25
TM5 197 A 5.43x44 MC4 receptor 6W25 GPR88 7EJX
TM5 198 A 5.44x45 MC4 receptor 6W25 GPR88 7EJX
TM5 199 A 5.45x46 GPR88 7EJX GPR88 7EJX
TM5 200 A 5.46x461 GPR88 7EJX GPR88 7EJX
TM5 201 L 5.47x47 GPR88 7EJX GPR88 7EJX
TM5 202 L 5.48x48 MC4 receptor 6W25 GPR88 7EJX
TM5 203 A 5.49x49 MC4 receptor 6W25 GPR88 7EJX
TM5 204 Q 5.50x50 MC4 receptor 6W25 GPR88 7EJX
TM5 205 T 5.51x51 MC4 receptor 6W25 GPR88 7EJX
TM5 206 A 5.52x52 MC4 receptor 6W25 MC4 receptor 6W25
TM5 207 L 5.53x53 MC4 receptor 6W25 MC4 receptor 6W25
TM5 208 L 5.54x54 MC4 receptor 6W25 GPR88 7EJX
TM5 209 L 5.55x55 MC4 receptor 6W25 GPR88 7EJX
TM5 210 H 5.56x56 MC4 receptor 6W25 GPR88 7EJX
TM5 211 C 5.57x57 MC4 receptor 6W25 GPR88 7EJX
TM5 212 Y 5.58x58 MC4 receptor 6W25 MC4 receptor 6W25
TM5 213 L 5.59x59 MC4 receptor 6W25 GPR88 7EJX
TM5 214 G 5.60x60 MC4 receptor 6W25 GPR88 7EJX
TM5 215 I 5.61x61 MC4 receptor 6W25 GPR88 7EJX
TM5 216 V 5.62x62 MC4 receptor 6W25 GPR88 7EJX
TM5 217 R 5.63x63 MC4 receptor 6W25 GPR88 7EJX
TM5 218 R 5.64x64 MC4 receptor 6W25 GPR88 7EJX
TM5 219 V 5.65x65 GPR88 7EJX GPR88 7EJX
TM5 220 R 5.66x66 GPR88 7EJX GPR88 7EJX
TM5 221 V 5.67x67 GPR88 7EJX GPR88 7EJX
TM5 222 S 5.68x68 GPR88 7EJX GPR88 7EJX
TM5 223 V 5.69x69 GPR88 7EJX GPR88 7EJX
TM5 224 K 5.70x70 GPR88 7EJX GPR88 7EJX
TM5 225 R 5.71x71 GPR88 7EJX GPR88 7EJX
TM5 226 V 5.72x72 GPR88 7EJX GPR88 7EJX
TM5 227 S 5.73x73 GPR88 7EJX GPR88 7EJX
TM5 228 V 5.74x74 GPR88 7EJX GPR88 7EJX
ICL3 229 L - - - - -
ICL3 230 N - - - - -
ICL3 231 F - - - - -
ICL3 232 H - - - - -
ICL3 233 L - - - - -
ICL3 278 Q - - - - -
ICL3 279 R - - - - -
ICL3 280 R - - - - -
ICL3 281 L - - - - -
ICL3 282 S - - - - -
TM6 283 G 6.34x34 MC4 receptor 6W25 GPR88 7EJX
TM6 284 L 6.35x35 MC4 receptor 6W25 GPR88 7EJX
TM6 285 S 6.36x36 MC4 receptor 6W25 GPR88 7EJX
TM6 286 V 6.37x37 MC4 receptor 6W25 GPR88 7EJX
TM6 287 L 6.38x38 MC4 receptor 6W25 GPR88 7EJX
TM6 288 L 6.39x39 MC4 receptor 6W25 GPR88 7EJX
TM6 289 L 6.40x40 MC4 receptor 6W25 MC4 receptor 6W25
TM6 290 C 6.41x41 MC4 receptor 6W25 GPR88 7EJX
TM6 291 C 6.42x42 MC4 receptor 6W25 GPR88 7EJX
TM6 292 V 6.43x43 MC4 receptor 6W25 MC4 receptor 6W25
TM6 293 F 6.44x44 MC4 receptor 6W25 MC4 receptor 6W25
TM6 294 L 6.45x45 MC4 receptor 6W25 GPR88 7EJX
TM6 295 L 6.46x46 MC4 receptor 6W25 GPR88 7EJX
TM6 296 A 6.47x47 MC4 receptor 6W25 GPR88 7EJX
TM6 297 T 6.48x48 MC4 receptor 6W25 GPR88 7EJX
TM6 298 Q 6.49x49 MC4 receptor 6W25 GPR88 7EJX
TM6 299 P 6.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM6 300 L 6.51x51 MC4 receptor 6W25 GPR88 7EJX
TM6 301 V 6.52x52 MC4 receptor 6W25 GPR88 7EJX
TM6 302 W 6.53x53 MC4 receptor 6W25 GPR88 7EJX
TM6 303 V 6.54x54 MC4 receptor 6W25 GPR88 7EJX
TM6 304 S 6.55x55 MC4 receptor 6W25 GPR88 7EJX
TM6 305 L 6.56x56 MC4 receptor 6W25 GPR88 7EJX
TM6 306 A 6.57x57 MC4 receptor 6W25 GPR88 7EJX
TM6 307 S 6.58x58 MC4 receptor 6W25 GPR88 7EJX
TM6 308 G 6.59x59 MC4 receptor 6W25 GPR88 7EJX
TM6 309 F 6.60x60 MC4 receptor 6W25 β1-adrenoceptor 7BVQ
TM6 310 S 6.61x61 MC4 receptor 6W25 5-HT1E receptor 7E33
ECL3 311 L - - - - -
ECL3 312 P - GPR52 6LI0 - -
ECL3 313 V - - - - -
TM7 314 P 7.31x30 GPR88 7EJX GPR88 7EJX
TM7 315 W 7.32x31 GPR88 7EJX GPR88 7EJX
TM7 316 G 7.33x32 GPR88 7EJX GPR88 7EJX
TM7 317 V 7.34x33 MC4 receptor 6W25 GPR88 7EJX
TM7 318 Q 7.35x34 MC4 receptor 6W25 GPR88 7EJX
TM7 319 A 7.36x35 MC4 receptor 6W25 GPR88 7EJX
TM7 320 A 7.37x36 MC4 receptor 6W25 GPR88 7EJX
TM7 321 S 7.38x37 MC4 receptor 6W25 GPR88 7EJX
TM7 322 W 7.39x38 MC4 receptor 6W25 GPR88 7EJX
TM7 323 L 7.40x39 MC4 receptor 6W25 GPR88 7EJX
TM7 324 L 7.41x40 MC4 receptor 6W25 MC4 receptor 6W25
TM7 325 C 7.42x41 MC4 receptor 6W25 GPR88 7EJX
TM7 326 C 7.43x42 MC4 receptor 6W25 GPR88 7EJX
TM7 327 A 7.44x43 MC4 receptor 6W25 GPR88 7EJX
TM7 328 L 7.45x45 MC4 receptor 6W25 GPR88 7EJX
TM7 329 S 7.46x46 MC4 receptor 6W25 MC4 receptor 6W25
TM7 330 A 7.47x47 MC4 receptor 6W25 GPR88 7EJX
TM7 331 L 7.48x48 MC4 receptor 6W25 GPR88 7EJX
TM7 332 N 7.49x49 MC4 receptor 6W25 GPR88 7EJX
TM7 333 P 7.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM7 334 L 7.51x51 MC4 receptor 6W25 MC4 receptor 6W25
TM7 335 L 7.52x52 MC4 receptor 6W25 GPR88 7EJX
TM7 336 Y 7.53x53 MC4 receptor 6W25 MC4 receptor 6W25
TM7 337 T 7.54x54 MC4 receptor 6W25 GPR88 7EJX
TM7 338 W 7.55x55 MC4 receptor 6W25 GPR88 7EJX
ICL4 339 R - - - - -
H8 340 N 8.47x47 MC4 receptor 6W25 GPR88 7EJX
H8 341 E 8.48x48 MC4 receptor 6W25 GPR88 7EJX
H8 342 E 8.49x49 MC4 receptor 6W25 MC4 receptor 6W25
H8 343 F 8.50x50 MC4 receptor 6W25 GPR88 7EJX
H8 344 R 8.51x51 MC4 receptor 6W25 MC4 receptor 6W25
H8 345 R 8.52x52 MC4 receptor 6W25 GPR88 7EJX
H8 346 S 8.53x53 MC4 receptor 6W25 GPR88 7EJX
H8 347 V 8.54x54 MC4 receptor 6W25 GPR88 7EJX
H8 348 R 8.55x55 MC4 receptor 6W25 GPR88 7EJX
H8 349 S 8.56x56 MC4 receptor 6W25 GPR88 7EJX
H8 350 V 8.57x57 MC4 receptor 6W25 GPR88 7EJX
H8 351 L 8.58x58 MC4 receptor 6W25 β1-adrenoceptor 7BVQ
H8 352 P 8.59x59 MC4 receptor 6W25 - -
C-term 353 G - - - - -
C-term 354 V - - - - -
C-term 355 G - - - - -
C-term 356 D - - - - -
C-term 357 A - - - - -