BB2 receptor homology model
PROTEIN CLASS
Class A (Rhodopsin)
RECEPTOR
SPECIES
Homo sapiens
STATE
Intermediate
VERSION
2020-09-02
MODEL
TEMPLATES
5X93 (ETB receptor)
5NDD (PAR2)
5WS3 (OX2 receptor)
6B73 (κ receptor)
6LW5 (FPR2/ALX)
6KO5 (ghrelin receptor)
3SN6 (β2-adrenoceptor)
4UHR (A2A receptor)
None
5NDD (PAR2)
5WS3 (OX2 receptor)
6B73 (κ receptor)
6LW5 (FPR2/ALX)
6KO5 (ghrelin receptor)
3SN6 (β2-adrenoceptor)
4UHR (A2A receptor)
None
| Main template (%) | Additional templates (%) | No template - freely modelled (%) | |
|---|---|---|---|
| Backbone | 71.2 | 16.6 | 12.2 |
| Side-chains | 16.2 | 60.9 | 22.8 |
Number of backbone templates: 8
Number of rotamer templates: 48
| Segment | Seq.num. | AA | GPCRdb# | Backbone | PDB | Rotamer | PDB |
|---|---|---|---|---|---|---|---|
| N-term | 25 | S | ETB receptor | 5X93 | ETB receptor | 5X93 | |
| N-term | 26 | A | ETB receptor | 5X93 | ETB receptor | 5X93 | |
| N-term | 27 | D | ETB receptor | 5X93 | ETB receptor | 5X93 | |
| N-term | 28 | L | ETB receptor | 5X93 | ETB receptor | 5X93 | |
| N-term | 29 | P | ETB receptor | 5X93 | ETB receptor | 5X93 | |
| TM1 | 30 | V | 1.22x22 | ETB receptor | 5X93 | - | - |
| TM1 | 31 | N | 1.23x23 | ETB receptor | 5X93 | - | - |
| TM1 | 32 | D | 1.24x24 | ETB receptor | 5X93 | - | - |
| TM1 | 33 | D | 1.25x25 | ETB receptor | 5X93 | - | - |
| TM1 | 34 | W | 1.26x26 | ETB receptor | 5X93 | - | - |
| TM1 | 35 | S | 1.27x27 | ETB receptor | 5X93 | δ receptor | 4N6H |
| TM1 | 36 | H | 1.28x28 | PAR2 | 5NDD | AT1 receptor | 4ZUD |
| TM1 | 37 | P | 1.29x29 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM1 | 38 | G | 1.30x30 | PAR2 | 5NDD | NOP receptor | 5DHG |
| TM1 | 39 | I | 1.31x31 | PAR2 | 5NDD | κ receptor | 6B73 |
| TM1 | 40 | L | 1.32x32 | PAR2 | 5NDD | ghrelin receptor | 6KO5 |
| TM1 | 41 | Y | 1.33x33 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM1 | 42 | V | 1.34x34 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM1 | 43 | I | 1.35x35 | PAR2 | 5NDD | apelin receptor | 5VBL |
| TM1 | 44 | P | 1.36x36 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 45 | A | 1.37x37 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM1 | 46 | V | 1.38x38 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 47 | Y | 1.39x39 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 48 | G | 1.40x40 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM1 | 49 | V | 1.41x41 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM1 | 50 | I | 1.42x42 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM1 | 51 | I | 1.43x43 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM1 | 52 | L | 1.44x44 | PAR2 | 5NDD | apelin receptor | 5VBL |
| TM1 | 53 | I | 1.45x45 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM1 | 54 | G | 1.46x46 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM1 | 55 | L | 1.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 56 | I | 1.48x48 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM1 | 57 | G | 1.49x49 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM1 | 58 | N | 1.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 59 | I | 1.51x51 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM1 | 60 | T | 1.52x52 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM1 | 61 | L | 1.53x53 | PAR2 | 5NDD | ETB receptor | 5X93 |
| TM1 | 62 | I | 1.54x54 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM1 | 63 | K | 1.55x55 | PAR2 | 5NDD | - | - |
| TM1 | 64 | I | 1.56x56 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM1 | 65 | F | 1.57x57 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 66 | C | 1.58x58 | PAR2 | 5NDD | AT2 receptor | 6JOD |
| TM1 | 67 | T | 1.59x59 | PAR2 | 5NDD | α2C-adrenoceptor | 6KUW |
| TM1 | 68 | V | 1.60x60 | PAR2 | 5NDD | - | - |
| ICL1 | 69 | K | 12.48x48 | - | - | - | - |
| ICL1 | 70 | S | 12.49x49 | OX2 receptor | 5WS3 | α2B-adrenoceptor | 6K41 |
| ICL1 | 71 | M | 12.50x50 | OX2 receptor | 5WS3 | OX2 receptor | 5WS3 |
| ICL1 | 72 | R | 12.51x51 | - | - | - | - |
| TM2 | 73 | N | 2.37x37 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM2 | 74 | V | 2.38x38 | PAR2 | 5NDD | OX2 receptor | 5WS3 |
| TM2 | 75 | P | 2.39x39 | PAR2 | 5NDD | ETB receptor | 5X93 |
| TM2 | 76 | N | 2.40x40 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM2 | 77 | L | 2.41x41 | PAR2 | 5NDD | OX2 receptor | 6TPN |
| TM2 | 78 | F | 2.42x42 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM2 | 79 | I | 2.43x43 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM2 | 80 | S | 2.44x44 | PAR2 | 5NDD | ghrelin receptor | 6KO5 |
| TM2 | 81 | S | 2.45x45 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM2 | 82 | L | 2.46x46 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 83 | A | 2.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 84 | L | 2.48x48 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 85 | G | 2.49x49 | PAR2 | 5NDD | ETB receptor | 5X93 |
| TM2 | 86 | D | 2.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 87 | L | 2.51x51 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 88 | L | 2.52x52 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 89 | L | 2.53x53 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM2 | 90 | L | 2.54x54 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM2 | 91 | I | 2.55x55 | ETB receptor | 5X93 | ETB receptor | 5X93 |
| TM2 | 92 | T | 2.56x551 | ETB receptor | 5X93 | OX2 receptor | 5WS3 |
| TM2 | 93 | C | 2.57x56 | ETB receptor | 5X93 | OX2 receptor | 5WS3 |
| TM2 | 94 | A | 2.58x57 | PAR2 | 5NDD | BLT1 receptor | 5X33 |
| TM2 | 95 | P | 2.59x58 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 96 | V | 2.60x59 | PAR2 | 5NDD | NK1 receptor | 6HLP |
| TM2 | 97 | D | 2.61x60 | PAR2 | 5NDD | ghrelin receptor | 6KO5 |
| TM2 | 98 | A | 2.62x61 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM2 | 99 | S | 2.63x62 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM2 | 100 | R | 2.64x63 | PAR2 | 5NDD | ghrelin receptor | 6KO5 |
| TM2 | 101 | Y | 2.65x64 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM2 | 102 | L | 2.66x65 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM2 | 103 | A | 2.67x66 | PAR2 | 5NDD | TP receptor | 6IIV |
| ECL1 | 104 | D | - | - | - | - | |
| ECL1 | 105 | R | 23.49x49 | ETB receptor | 5X93 | AT1 receptor | 4ZUD |
| ECL1 | 106 | W | 23.50x50 | ETB receptor | 5X93 | ETB receptor | 5X93 |
| ECL1 | 107 | L | 23.51x51 | ETB receptor | 5X93 | CysLT1 receptor | 6RZ5 |
| ECL1 | 108 | F | 23.52x52 | - | - | - | - |
| TM3 | 109 | G | 3.21x21 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 110 | R | 3.22x22 | PAR2 | 5NDD | 5-HT2C receptor | 6BQH |
| TM3 | 111 | I | 3.23x23 | PAR2 | 5NDD | μ receptor | 5C1M |
| TM3 | 112 | G | 3.24x24 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM3 | 113 | C | 3.25x25 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 114 | K | 3.26x26 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM3 | 115 | L | 3.27x27 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM3 | 116 | I | 3.28x28 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM3 | 117 | P | 3.29x29 | PAR2 | 5NDD | ETB receptor | 5X93 |
| TM3 | 118 | F | 3.30x30 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM3 | 119 | I | 3.31x31 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM3 | 120 | Q | 3.32x32 | PAR2 | 5NDD | ETB receptor | 5X93 |
| TM3 | 121 | L | 3.33x33 | PAR2 | 5NDD | A2A receptor | 4UHR |
| TM3 | 122 | T | 3.34x34 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM3 | 123 | S | 3.35x35 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM3 | 124 | V | 3.36x36 | PAR2 | 5NDD | ETB receptor | 5X93 |
| TM3 | 125 | G | 3.37x37 | PAR2 | 5NDD | ETB receptor | 5X93 |
| TM3 | 126 | V | 3.38x38 | PAR2 | 5NDD | OX2 receptor | 5WS3 |
| TM3 | 127 | S | 3.39x39 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 128 | V | 3.40x40 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM3 | 129 | F | 3.41x41 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM3 | 130 | T | 3.42x42 | PAR2 | 5NDD | OX2 receptor | 5WS3 |
| TM3 | 131 | L | 3.43x43 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 132 | T | 3.44x44 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 133 | A | 3.45x45 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM3 | 134 | L | 3.46x46 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 135 | S | 3.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 136 | A | 3.48x48 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM3 | 137 | D | 3.49x49 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM3 | 138 | R | 3.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 139 | Y | 3.51x51 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM3 | 140 | K | 3.52x52 | PAR2 | 5NDD | - | - |
| TM3 | 141 | A | 3.53x53 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM3 | 142 | I | 3.54x54 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 143 | V | 3.55x55 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 144 | R | 3.56x56 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| ICL2 | 145 | P | 34.50x50 | - | - | - | - |
| ICL2 | 146 | M | 34.51x51 | κ receptor | 6B73 | MT2 receptor | 6ME7 |
| ICL2 | 147 | D | 34.52x52 | κ receptor | 6B73 | - | - |
| ICL2 | 148 | I | 34.53x53 | κ receptor | 6B73 | - | - |
| ICL2 | 149 | Q | 34.54x54 | κ receptor | 6B73 | FFA1 receptor | 5TZY |
| ICL2 | 150 | A | 34.55x55 | κ receptor | 6B73 | FFA1 receptor | 5TZY |
| ICL2 | 151 | S | 34.56x56 | κ receptor | 6B73 | - | - |
| ICL2 | 152 | H | 34.57x57 | - | - | - | - |
| TM4 | 153 | A | 4.38x38 | PAR2 | 5NDD | - | - |
| TM4 | 154 | L | 4.39x39 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM4 | 155 | M | 4.40x40 | PAR2 | 5NDD | - | - |
| TM4 | 156 | K | 4.41x41 | PAR2 | 5NDD | CysLT1 receptor | 6RZ5 |
| TM4 | 157 | I | 4.42x42 | PAR2 | 5NDD | α2A-adrenoceptor | 6KUX |
| TM4 | 158 | C | 4.43x43 | PAR2 | 5NDD | US28 | 5WB1 |
| TM4 | 159 | L | 4.44x44 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM4 | 160 | K | 4.45x45 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM4 | 161 | A | 4.46x46 | PAR2 | 5NDD | - | - |
| TM4 | 162 | A | 4.47x47 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM4 | 163 | F | 4.48x48 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM4 | 164 | I | 4.49x49 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 165 | W | 4.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 166 | I | 4.51x51 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM4 | 167 | I | 4.52x52 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM4 | 168 | S | 4.53x53 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM4 | 169 | M | 4.54x54 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM4 | 170 | L | 4.55x55 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 171 | L | 4.56x56 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM4 | 172 | A | 4.57x57 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM4 | 173 | I | 4.58x59 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 174 | P | 4.59x60 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 175 | E | 4.60x61 | PAR2 | 5NDD | ETB receptor | 5X93 |
| TM4 | 176 | A | 4.61x62 | PAR2 | 5NDD | ETB receptor | 5X93 |
| TM4 | 177 | V | 4.62x63 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 178 | F | 4.63x64 | ETB receptor | 5X93 | succinate receptor | 6RNK |
| TM4 | 179 | S | 4.64x65 | ETB receptor | 5X93 | NK1 receptor | 6HLP |
| ECL2 | 180 | D | - | - | - | - | |
| ECL2 | 181 | L | - | - | - | - | |
| ECL2 | 182 | H | - | - | - | - | |
| ECL2 | 183 | P | - | - | - | - | |
| ECL2 | 184 | F | - | - | - | - | |
| ECL2 | 185 | H | - | - | - | - | |
| ECL2 | 186 | E | - | - | - | - | |
| ECL2 | 187 | E | - | - | - | - | |
| ECL2 | 188 | S | - | - | - | - | |
| ECL2 | 189 | T | - | - | - | - | |
| ECL2 | 190 | N | - | - | - | - | |
| ECL2 | 191 | Q | - | - | - | - | |
| ECL2 | 192 | T | - | - | - | - | |
| ECL2 | 193 | F | - | - | - | - | |
| ECL2 | 194 | I | - | - | - | - | |
| ECL2 | 195 | S | - | - | - | - | |
| ECL2 | 196 | C | 45.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| ECL2 | 197 | A | 45.51x51 | PAR2 | 5NDD | GPR52 | 6LI1 |
| ECL2 | 198 | P | 45.52x52 | PAR2 | 5NDD | - | - |
| ECL2 | 199 | Y | - | - | - | - | |
| TM5 | 200 | P | 5.28x28 | FPR2/ALX | 6LW5 | - | - |
| TM5 | 201 | H | 5.29x29 | FPR2/ALX | 6LW5 | - | - |
| TM5 | 202 | S | 5.30x30 | FPR2/ALX | 6LW5 | - | - |
| TM5 | 203 | N | 5.31x31 | FPR2/ALX | 6LW5 | - | - |
| TM5 | 204 | E | 5.32x32 | PAR2 | 5NDD | apelin receptor | 5VBL |
| TM5 | 205 | L | 5.33x33 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM5 | 206 | H | 5.34x34 | PAR2 | 5NDD | - | - |
| TM5 | 207 | P | 5.35x35 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM5 | 208 | K | 5.36x36 | PAR2 | 5NDD | CCR6 | 6WWZ |
| TM5 | 209 | I | 5.37x37 | PAR2 | 5NDD | AT1 receptor | 4ZUD |
| TM5 | 210 | H | 5.38x38 | PAR2 | 5NDD | S1P1 receptor | 3V2Y |
| TM5 | 211 | S | 5.39x39 | PAR2 | 5NDD | - | - |
| TM5 | 212 | M | 5.40x40 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM5 | 213 | A | 5.41x41 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM5 | 214 | S | 5.42x42 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 215 | F | 5.43x43 | PAR2 | 5NDD | TP receptor | 6IIV |
| TM5 | 216 | L | 5.44x44 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM5 | 217 | V | 5.45x45 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM5 | 218 | F | 5.46x46 | ghrelin receptor | 6KO5 | ghrelin receptor | 6KO5 |
| TM5 | 219 | Y | 5.47x47 | ghrelin receptor | 6KO5 | OX2 receptor | 5WS3 |
| TM5 | 220 | V | 5.48x48 | PAR2 | 5NDD | apelin receptor | 5VBL |
| TM5 | 221 | I | 5.49x49 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM5 | 222 | P | 5.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 223 | L | 5.51x51 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM5 | 224 | S | 5.52x52 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM5 | 225 | I | 5.53x53 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM5 | 226 | I | 5.54x54 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM5 | 227 | S | 5.55x55 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM5 | 228 | V | 5.56x56 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM5 | 229 | Y | 5.57x57 | PAR2 | 5NDD | - | - |
| TM5 | 230 | Y | 5.58x58 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 231 | Y | 5.59x59 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM5 | 232 | F | 5.60x60 | PAR2 | 5NDD | apelin receptor | 5VBL |
| TM5 | 233 | I | 5.61x61 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM5 | 234 | A | 5.62x62 | PAR2 | 5NDD | apelin receptor | 5VBL |
| TM5 | 235 | K | 5.63x63 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM5 | 236 | N | 5.64x64 | PAR2 | 5NDD | - | - |
| TM5 | 237 | L | 5.65x65 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 238 | I | 5.66x66 | β2-adrenoceptor | 3SN6 | P2Y1 receptor | 4XNW |
| TM5 | 239 | Q | 5.67x67 | β2-adrenoceptor | 3SN6 | MT1 receptor | 6ME2 |
| TM5 | 240 | S | 5.68x68 | β2-adrenoceptor | 3SN6 | P2Y12 receptor | 4NTJ |
| TM5 | 241 | A | 5.69x69 | β2-adrenoceptor | 3SN6 | 5-HT2B receptor | 4IB4 |
| TM5 | 242 | Y | 5.70x70 | β2-adrenoceptor | 3SN6 | - | - |
| TM5 | 243 | N | 5.71x71 | β2-adrenoceptor | 3SN6 | - | - |
| TM5 | 244 | L | 5.72x72 | β2-adrenoceptor | 3SN6 | M1 receptor | 6OIJ |
| TM5 | 245 | P | 5.73x73 | β2-adrenoceptor | 3SN6 | - | - |
| ICL3 | 246 | V | - | - | - | - | |
| ICL3 | 247 | E | - | - | - | - | |
| ICL3 | 248 | G | - | - | - | - | |
| ICL3 | 249 | N | - | - | - | - | |
| ICL3 | 250 | I | - | - | - | - | |
| TM6 | 251 | H | 6.22x22 | A2A receptor | 4UHR | - | - |
| TM6 | 252 | V | 6.23x23 | A2A receptor | 4UHR | - | - |
| TM6 | 253 | K | 6.24x24 | A2A receptor | 4UHR | δ receptor | 6PT2 |
| TM6 | 254 | K | 6.25x25 | A2A receptor | 4UHR | OX2 receptor | 5WS3 |
| TM6 | 255 | Q | 6.26x26 | A2A receptor | 4UHR | OX2 receptor | 5WS3 |
| TM6 | 256 | I | 6.27x27 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM6 | 257 | E | 6.28x28 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 258 | S | 6.29x29 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM6 | 259 | R | 6.30x30 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM6 | 260 | K | 6.31x31 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM6 | 261 | R | 6.32x32 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM6 | 262 | L | 6.33x33 | PAR2 | 5NDD | apelin receptor | 5VBL |
| TM6 | 263 | A | 6.34x34 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 264 | K | 6.35x35 | PAR2 | 5NDD | ETB receptor | 5X93 |
| TM6 | 265 | T | 6.36x36 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM6 | 266 | V | 6.37x37 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM6 | 267 | L | 6.38x38 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM6 | 268 | V | 6.39x39 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 269 | F | 6.40x40 | PAR2 | 5NDD | - | - |
| TM6 | 270 | V | 6.41x41 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 271 | G | 6.42x42 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM6 | 272 | L | 6.43x43 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM6 | 273 | F | 6.44x44 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM6 | 274 | A | 6.45x45 | PAR2 | 5NDD | TP receptor | 6IIV |
| TM6 | 275 | F | 6.46x46 | ETB receptor | 5X93 | LPA6 receptor | 5XSZ |
| TM6 | 276 | C | 6.47x47 | ETB receptor | 5X93 | ETB receptor | 5X93 |
| TM6 | 277 | W | 6.48x48 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM6 | 278 | L | 6.49x49 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM6 | 279 | P | 6.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 280 | N | 6.51x51 | PAR2 | 5NDD | - | - |
| TM6 | 281 | H | 6.52x52 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM6 | 282 | V | 6.53x53 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM6 | 283 | I | 6.54x54 | PAR2 | 5NDD | MT2 receptor | 6ME6 |
| TM6 | 284 | Y | 6.55x55 | PAR2 | 5NDD | α2C-adrenoceptor | 6KUW |
| TM6 | 285 | L | 6.56x56 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM6 | 286 | Y | 6.57x57 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM6 | 287 | R | 6.58x58 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM6 | 288 | S | 6.59x59 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM6 | 289 | Y | 6.60x60 | PAR2 | 5NDD | NTS1 receptor | 4BUO |
| TM6 | 290 | H | 6.61x61 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| ECL3 | 291 | Y | - | - | - | - | |
| ECL3 | 292 | S | - | - | - | - | |
| ECL3 | 293 | E | - | - | - | - | |
| ECL3 | 294 | V | - | - | - | - | |
| ECL3 | 295 | D | - | - | - | - | |
| ECL3 | 296 | T | - | - | - | - | |
| TM7 | 297 | S | 7.28x27 | ETB receptor | 5X93 | CCR7 | 6QZH |
| TM7 | 298 | M | 7.29x28 | ETB receptor | 5X93 | - | - |
| TM7 | 299 | L | 7.30x29 | ETB receptor | 5X93 | δ receptor | 4N6H |
| TM7 | 300 | H | 7.31x30 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM7 | 301 | F | 7.32x31 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM7 | 302 | V | 7.33x32 | PAR2 | 5NDD | ETB receptor | 5X93 |
| TM7 | 303 | T | 7.34x33 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM7 | 304 | S | 7.35x34 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM7 | 305 | I | 7.36x35 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 306 | C | 7.37x36 | PAR2 | 5NDD | - | - |
| TM7 | 307 | A | 7.38x37 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 308 | R | 7.39x38 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM7 | 309 | L | 7.40x39 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM7 | 310 | L | 7.41x40 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 311 | A | 7.42x41 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM7 | 312 | F | 7.43x42 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM7 | 313 | T | 7.44x43 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM7 | 314 | N | 7.45x45 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 315 | S | 7.46x46 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 316 | C | 7.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 317 | V | 7.48x48 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM7 | 318 | N | 7.49x49 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM7 | 319 | P | 7.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 320 | F | 7.51x51 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 321 | A | 7.52x52 | PAR2 | 5NDD | ETB receptor | 5X93 |
| TM7 | 322 | L | 7.53x53 | PAR2 | 5NDD | ETB receptor | 5X93 |
| TM7 | 323 | Y | 7.54x54 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 324 | L | 7.55x55 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM7 | 325 | L | 7.56x56 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| H8 | 326 | S | 8.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| H8 | 327 | K | 8.48x48 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| H8 | 328 | S | 8.49x49 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| H8 | 329 | F | 8.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| H8 | 330 | R | 8.51x51 | PAR2 | 5NDD | PAR2 | 5NDD |
| H8 | 331 | K | 8.52x52 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| H8 | 332 | Q | 8.53x53 | PAR2 | 5NDD | OX1 receptor | 6TO7 |
| H8 | 333 | F | 8.54x54 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| H8 | 334 | N | 8.55x55 | PAR2 | 5NDD | - | - |
| H8 | 335 | T | 8.56x56 | PAR2 | 5NDD | M3 receptor | 5ZHP |
| H8 | 336 | Q | 8.57x57 | PAR2 | 5NDD | - | - |
| H8 | 337 | L | 8.58x58 | PAR2 | 5NDD | PAR2 | 5NDD |
| H8 | 338 | L | 8.59x59 | ETB receptor | 5X93 | apelin receptor | 5VBL |
| H8 | 339 | C | 8.60x60 | ETB receptor | 5X93 | ETB receptor | 5X93 |
| C-term | 340 | C | - | - | - | - | |
| C-term | 341 | Q | - | - | - | - | |
| C-term | 342 | P | - | - | - | - | |
| C-term | 343 | G | - | - | - | - | |
| C-term | 344 | L | - | - | - | - |