kisspeptin receptor homology model
PROTEIN CLASS
Class A (Rhodopsin)
RECEPTOR
SPECIES
Homo sapiens
STATE
Intermediate
VERSION
2021-02-08
MODEL
TEMPLATES
3VW7 (PAR1)
6VI4 (κ receptor)
6B73 (κ receptor)
4DJH (κ receptor)
6TO7 (OX1 receptor)
6LI3 (GPR52)
7CFN (GPBA receptor)
None
6VI4 (κ receptor)
6B73 (κ receptor)
4DJH (κ receptor)
6TO7 (OX1 receptor)
6LI3 (GPR52)
7CFN (GPBA receptor)
None
| Main template (%) | Additional templates (%) | No template - freely modelled (%) | |
|---|---|---|---|
| Backbone | 71.9 | 19.7 | 8.4 |
| Side-chains | 19.0 | 62.3 | 18.7 |
Number of backbone templates: 7
Number of rotamer templates: 47
| Segment | Seq.num. | AA | GPCRdb# | Backbone | PDB | Rotamer | PDB |
|---|---|---|---|---|---|---|---|
| N-term | 35 | P | PAR1 | 3VW7 | PAR1 | 3VW7 | |
| N-term | 36 | S | PAR1 | 3VW7 | PAR1 | 3VW7 | |
| N-term | 37 | P | PAR1 | 3VW7 | PAR1 | 3VW7 | |
| N-term | 38 | R | PAR1 | 3VW7 | PAR1 | 3VW7 | |
| N-term | 39 | A | PAR1 | 3VW7 | PAR1 | 3VW7 | |
| TM1 | 40 | V | 1.30x30 | PAR1 | 3VW7 | μ receptor | 5C1M |
| TM1 | 41 | D | 1.31x31 | PAR1 | 3VW7 | - | - |
| TM1 | 42 | A | 1.32x32 | PAR1 | 3VW7 | μ receptor | 5C1M |
| TM1 | 43 | W | 1.33x33 | PAR1 | 3VW7 | OX1 receptor | 6TO7 |
| TM1 | 44 | L | 1.34x34 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM1 | 45 | V | 1.35x35 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 46 | P | 1.36x36 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 47 | L | 1.37x37 | PAR1 | 3VW7 | P2Y12 receptor | 4NTJ |
| TM1 | 48 | F | 1.38x38 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM1 | 49 | F | 1.39x39 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM1 | 50 | A | 1.40x40 | PAR1 | 3VW7 | TP receptor | 6IIV |
| TM1 | 51 | A | 1.41x41 | PAR1 | 3VW7 | FFA1 receptor | 5TZY |
| TM1 | 52 | L | 1.42x42 | PAR1 | 3VW7 | Rhodopsin | 1GZM |
| TM1 | 53 | M | 1.43x43 | PAR1 | 3VW7 | BLT1 receptor | 5X33 |
| TM1 | 54 | L | 1.44x44 | PAR1 | 3VW7 | Y2 receptor | 7DDZ |
| TM1 | 55 | L | 1.45x45 | PAR1 | 3VW7 | Rhodopsin | 1GZM |
| TM1 | 56 | G | 1.46x46 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM1 | 57 | L | 1.47x47 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 58 | V | 1.48x48 | PAR1 | 3VW7 | κ receptor | 6B73 |
| TM1 | 59 | G | 1.49x49 | PAR1 | 3VW7 | P2Y1 receptor | 4XNW |
| TM1 | 60 | N | 1.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 61 | S | 1.51x51 | PAR1 | 3VW7 | P2Y1 receptor | 4XNW |
| TM1 | 62 | L | 1.52x52 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM1 | 63 | V | 1.53x53 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM1 | 64 | I | 1.54x54 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 65 | Y | 1.55x55 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM1 | 66 | V | 1.56x56 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 67 | I | 1.57x57 | PAR1 | 3VW7 | MC4 receptor | 6W25 |
| TM1 | 68 | C | 1.58x58 | PAR1 | 3VW7 | AT2 receptor | 6JOD |
| TM1 | 69 | R | 1.59x59 | PAR1 | 3VW7 | κ receptor | 4DJH |
| TM1 | 70 | H | 1.60x60 | PAR1 | 3VW7 | P2Y1 receptor | 4XNW |
| ICL1 | 71 | K | 12.48x48 | - | - | - | - |
| ICL1 | 72 | P | 12.49x49 | κ receptor | 6VI4 | - | - |
| ICL1 | 73 | M | 12.50x50 | κ receptor | 6VI4 | κ receptor | 6VI4 |
| ICL1 | 74 | R | 12.51x51 | - | - | - | - |
| TM2 | 75 | T | 2.37x37 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM2 | 76 | V | 2.38x38 | PAR1 | 3VW7 | OX1 receptor | 6TO7 |
| TM2 | 77 | T | 2.39x39 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM2 | 78 | N | 2.40x40 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM2 | 79 | F | 2.41x41 | PAR1 | 3VW7 | MC4 receptor | 6W25 |
| TM2 | 80 | Y | 2.42x42 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 81 | I | 2.43x43 | PAR1 | 3VW7 | MC4 receptor | 6W25 |
| TM2 | 82 | A | 2.44x44 | PAR1 | 3VW7 | PAR2 | 5NDD |
| TM2 | 83 | N | 2.45x45 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM2 | 84 | L | 2.46x46 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 85 | A | 2.47x47 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 86 | A | 2.48x48 | PAR1 | 3VW7 | D4 receptor | 5WIV |
| TM2 | 87 | T | 2.49x49 | PAR1 | 3VW7 | TP receptor | 6IIV |
| TM2 | 88 | D | 2.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 89 | V | 2.51x51 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 90 | T | 2.52x52 | PAR1 | 3VW7 | apelin receptor | 5VBL |
| TM2 | 91 | F | 2.53x53 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 92 | L | 2.54x54 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM2 | 93 | L | 2.55x55 | OX1 receptor | 6TO7 | LPA6 receptor | 5XSZ |
| TM2 | 94 | C | 2.56x551 | OX1 receptor | 6TO7 | - | - |
| TM2 | 95 | C | 2.57x56 | OX1 receptor | 6TO7 | OX1 receptor | 6TO7 |
| TM2 | 96 | V | 2.58x57 | PAR1 | 3VW7 | β2-adrenoceptor | 5JQH |
| TM2 | 97 | P | 2.59x58 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 98 | F | 2.60x59 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 99 | T | 2.61x60 | PAR1 | 3VW7 | Rhodopsin | 1GZM |
| TM2 | 100 | A | 2.62x61 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM2 | 101 | L | 2.63x62 | PAR1 | 3VW7 | 5-HT2B receptor | 4IB4 |
| TM2 | 102 | L | 2.64x63 | PAR1 | 3VW7 | D3 receptor | 3PBL |
| TM2 | 103 | Y | 2.65x64 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 104 | P | 2.66x65 | PAR1 | 3VW7 | - | - |
| TM2 | 105 | L | 2.67x66 | PAR1 | 3VW7 | MC4 receptor | 6W25 |
| ECL1 | 106 | P | - | - | - | - | |
| ECL1 | 107 | G | 23.49x49 | κ receptor | 6B73 | CXCR2 | 6LFL |
| ECL1 | 108 | W | 23.50x50 | κ receptor | 6B73 | κ receptor | 6B73 |
| ECL1 | 109 | V | 23.51x51 | κ receptor | 6B73 | Rhodopsin | 1GZM |
| ECL1 | 110 | L | 23.52x52 | - | - | - | - |
| TM3 | 111 | G | 3.21x21 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 112 | D | 3.22x22 | PAR1 | 3VW7 | P2Y1 receptor | 4XNW |
| TM3 | 113 | F | 3.23x23 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM3 | 114 | M | 3.24x24 | PAR1 | 3VW7 | P2Y1 receptor | 4XNW |
| TM3 | 115 | C | 3.25x25 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 116 | K | 3.26x26 | PAR1 | 3VW7 | P2Y1 receptor | 4XNW |
| TM3 | 117 | F | 3.27x27 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 118 | V | 3.28x28 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 119 | N | 3.29x29 | PAR1 | 3VW7 | NK1 receptor | 6HLP |
| TM3 | 120 | Y | 3.30x30 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM3 | 121 | I | 3.31x31 | PAR1 | 3VW7 | P2Y1 receptor | 4XNW |
| TM3 | 122 | Q | 3.32x32 | PAR1 | 3VW7 | OX1 receptor | 6TO7 |
| TM3 | 123 | Q | 3.33x33 | PAR1 | 3VW7 | - | - |
| TM3 | 124 | V | 3.34x34 | PAR1 | 3VW7 | P2Y1 receptor | 4XNW |
| TM3 | 125 | S | 3.35x35 | PAR1 | 3VW7 | MC4 receptor | 6W25 |
| TM3 | 126 | V | 3.36x36 | PAR1 | 3VW7 | OX1 receptor | 6TO7 |
| TM3 | 127 | Q | 3.37x37 | PAR1 | 3VW7 | Y2 receptor | 7DDZ |
| TM3 | 128 | A | 3.38x38 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 129 | T | 3.39x39 | PAR1 | 3VW7 | ETB receptor | 5X93 |
| TM3 | 130 | C | 3.40x40 | PAR1 | 3VW7 | - | - |
| TM3 | 131 | A | 3.41x41 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM3 | 132 | T | 3.42x42 | PAR1 | 3VW7 | κ receptor | 6B73 |
| TM3 | 133 | L | 3.43x43 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM3 | 134 | T | 3.44x44 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 135 | A | 3.45x45 | PAR1 | 3VW7 | 5-HT2B receptor | 4IB4 |
| TM3 | 136 | M | 3.46x46 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM3 | 137 | S | 3.47x47 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 138 | V | 3.48x48 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM3 | 139 | D | 3.49x49 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 140 | R | 3.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 141 | W | 3.51x51 | PAR1 | 3VW7 | OX1 receptor | 6TO7 |
| TM3 | 142 | Y | 3.52x52 | PAR1 | 3VW7 | OX1 receptor | 6TO7 |
| TM3 | 143 | V | 3.53x53 | PAR1 | 3VW7 | Rhodopsin | 1GZM |
| TM3 | 144 | T | 3.54x54 | PAR1 | 3VW7 | P2Y12 receptor | 4NTJ |
| TM3 | 145 | V | 3.55x55 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 146 | F | 3.56x56 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| ICL2 | 147 | P | 34.50x50 | - | - | - | - |
| ICL2 | 148 | L | 34.51x51 | κ receptor | 6B73 | P2Y1 receptor | 4XNW |
| ICL2 | 149 | R | 34.52x52 | κ receptor | 6B73 | CXCR2 | 6LFO |
| ICL2 | 150 | A | 34.53x53 | κ receptor | 6B73 | κ receptor | 6B73 |
| ICL2 | 151 | L | 34.54x54 | κ receptor | 6B73 | κ receptor | 6B73 |
| ICL2 | 152 | H | 34.55x55 | κ receptor | 6B73 | D3 receptor | 3PBL |
| ICL2 | 153 | R | 34.56x56 | κ receptor | 6B73 | P2Y1 receptor | 4XNW |
| ICL2 | 154 | R | 34.57x57 | - | - | - | - |
| TM4 | 155 | T | 4.38x38 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM4 | 156 | P | 4.39x39 | PAR1 | 3VW7 | GPR52 | 6LI1 |
| TM4 | 157 | R | 4.40x40 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ8 |
| TM4 | 158 | L | 4.41x41 | PAR1 | 3VW7 | CXCR2 | 6LFL |
| TM4 | 159 | A | 4.42x42 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM4 | 160 | L | 4.43x43 | PAR1 | 3VW7 | OX1 receptor | 6TO7 |
| TM4 | 161 | A | 4.44x44 | PAR1 | 3VW7 | TP receptor | 6IIV |
| TM4 | 162 | V | 4.45x45 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM4 | 163 | S | 4.46x46 | PAR1 | 3VW7 | P2Y1 receptor | 4XNW |
| TM4 | 164 | L | 4.47x47 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM4 | 165 | S | 4.48x48 | PAR1 | 3VW7 | CXCR2 | 6LFL |
| TM4 | 166 | I | 4.49x49 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM4 | 167 | W | 4.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM4 | 168 | V | 4.51x51 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM4 | 169 | G | 4.52x52 | PAR1 | 3VW7 | OT receptor | 6TPK |
| TM4 | 170 | S | 4.53x53 | PAR1 | 3VW7 | 5-HT2B receptor | 4IB4 |
| TM4 | 171 | A | 4.54x54 | PAR1 | 3VW7 | Y2 receptor | 7DDZ |
| TM4 | 172 | A | 4.55x55 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM4 | 173 | V | 4.56x56 | PAR1 | 3VW7 | PAR2 | 5NDD |
| TM4 | 174 | S | 4.57x57 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM4 | 175 | A | 4.58x59 | PAR1 | 3VW7 | D4 receptor | 5WIV |
| TM4 | 176 | P | 4.59x60 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM4 | 177 | V | 4.60x61 | PAR1 | 3VW7 | 5-HT2B receptor | 4IB4 |
| TM4 | 178 | L | 4.61x62 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM4 | 179 | A | 4.62x63 | PAR1 | 3VW7 | OX1 receptor | 6TO7 |
| TM4 | 180 | L | 4.63x64 | PAR1 | 3VW7 | - | - |
| TM4 | 181 | H | 4.64x65 | OX1 receptor | 6TO7 | - | - |
| ECL2 | 182 | R | - | - | - | - | |
| ECL2 | 183 | L | - | - | - | - | |
| ECL2 | 184 | S | - | - | - | - | |
| ECL2 | 185 | P | - | - | - | - | |
| ECL2 | 186 | G | - | - | - | - | |
| ECL2 | 187 | P | - | - | - | - | |
| ECL2 | 188 | R | - | - | - | - | |
| ECL2 | 189 | A | - | - | - | - | |
| ECL2 | 190 | Y | - | - | - | - | |
| ECL2 | 191 | C | 45.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| ECL2 | 192 | S | 45.51x51 | PAR1 | 3VW7 | P2Y12 receptor | 4PXZ |
| ECL2 | 193 | E | 45.52x52 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| ECL2 | 194 | A | - | - | - | - | |
| ECL2 | 195 | F | - | - | - | - | |
| TM5 | 196 | P | 5.30x31 | κ receptor | 4DJH | - | - |
| TM5 | 197 | S | 5.31x32 | PAR1 | 3VW7 | Y1 receptor | 5ZBH |
| TM5 | 198 | R | 5.32x33 | PAR1 | 3VW7 | - | - |
| TM5 | 199 | A | 5.33x34 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM5 | 200 | L | 5.34x35 | PAR1 | 3VW7 | AT1 receptor | 4ZUD |
| TM5 | 201 | E | 5.35x36 | PAR1 | 3VW7 | μ receptor | 5C1M |
| TM5 | 202 | R | 5.36x37 | PAR1 | 3VW7 | D4 receptor | 5WIV |
| TM5 | 203 | A | 5.37x38 | PAR1 | 3VW7 | MC4 receptor | 6W25 |
| TM5 | 204 | F | 5.38x39 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM5 | 205 | A | 5.39x40 | PAR1 | 3VW7 | NOP receptor | 5DHG |
| TM5 | 206 | L | 5.40x41 | PAR1 | 3VW7 | PAR2 | 5NDD |
| TM5 | 207 | Y | 5.41x42 | PAR1 | 3VW7 | Rhodopsin | 1GZM |
| TM5 | 208 | N | 5.42x43 | PAR1 | 3VW7 | A2A receptor | 4UHR |
| TM5 | 209 | L | 5.43x44 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM5 | 210 | L | 5.44x45 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM5 | 211 | A | 5.45x46 | κ receptor | 6B73 | P2Y1 receptor | 4XNW |
| TM5 | 212 | L | 5.46x461 | κ receptor | 6B73 | GPR52 | 6LI1 |
| TM5 | 213 | Y | 5.47x47 | κ receptor | 6B73 | OX1 receptor | 6TO7 |
| TM5 | 214 | L | 5.48x48 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM5 | 215 | L | 5.49x49 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM5 | 216 | P | 5.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM5 | 217 | L | 5.51x51 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM5 | 218 | L | 5.52x52 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM5 | 219 | A | 5.53x53 | PAR1 | 3VW7 | CCR7 | 6QZH |
| TM5 | 220 | T | 5.54x54 | PAR1 | 3VW7 | PAR2 | 5NDD |
| TM5 | 221 | C | 5.55x55 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM5 | 222 | A | 5.56x56 | PAR1 | 3VW7 | 5-HT1B receptor | 4IAQ |
| TM5 | 223 | C | 5.57x57 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM5 | 224 | Y | 5.58x58 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM5 | 225 | A | 5.59x59 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM5 | 226 | A | 5.60x60 | PAR1 | 3VW7 | D4 receptor | 5WIV |
| TM5 | 227 | M | 5.61x61 | PAR1 | 3VW7 | PAR2 | 5NDD |
| TM5 | 228 | L | 5.62x62 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM5 | 229 | R | 5.63x63 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM5 | 230 | H | 5.64x64 | PAR1 | 3VW7 | AT2 receptor | 6JOD |
| TM5 | 231 | L | 5.65x65 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM5 | 232 | G | 5.66x66 | PAR1 | 3VW7 | - | - |
| TM5 | 233 | R | 5.67x67 | PAR1 | 3VW7 | - | - |
| TM5 | 234 | V | 5.68x68 | GPR52 | 6LI3 | CysLT2 receptor | 6RZ6 |
| TM5 | 235 | A | 5.69x69 | GPR52 | 6LI3 | 5-HT2B receptor | 4IB4 |
| TM5 | 236 | V | 5.70x70 | GPR52 | 6LI3 | P2Y12 receptor | 4NTJ |
| TM5 | 237 | R | 5.71x71 | GPR52 | 6LI3 | P2Y12 receptor | 4NTJ |
| TM5 | 238 | P | 5.72x72 | GPR52 | 6LI3 | - | - |
| TM5 | 239 | A | 5.73x73 | GPR52 | 6LI3 | NTS1 receptor | 6OSA |
| TM5 | 240 | P | 5.74x74 | GPR52 | 6LI3 | - | - |
| TM5 | 241 | A | 5.75x75 | GPR52 | 6LI3 | - | - |
| TM5 | 242 | D | 5.76x76 | GPR52 | 6LI3 | - | - |
| TM5 | 243 | S | 5.77x77 | GPR52 | 6LI3 | - | - |
| TM5 | 244 | A | 5.78x78 | GPR52 | 6LI3 | GPR52 | 6LI3 |
| TM5 | 245 | L | 5.79x79 | GPR52 | 6LI3 | - | - |
| TM5 | 246 | Q | 5.80x80 | GPR52 | 6LI3 | - | - |
| ICL3 | 247 | G | - | - | - | - | |
| ICL3 | 248 | Q | GPBA receptor | 7CFN | - | - | |
| ICL3 | 249 | V | GPBA receptor | 7CFN | - | - | |
| ICL3 | 250 | L | - | - | - | - | |
| TM6 | 251 | A | 6.23x23 | κ receptor | 6B73 | A2A receptor | 4UHR |
| TM6 | 252 | E | 6.24x24 | κ receptor | 6B73 | - | - |
| TM6 | 253 | R | 6.25x25 | κ receptor | 6B73 | LPA1 receptor | 4Z35 |
| TM6 | 254 | A | 6.26x26 | κ receptor | 6B73 | α2C-adrenoceptor | 6KUW |
| TM6 | 255 | G | 6.27x27 | PAR1 | 3VW7 | CXCR4 | 3ODU |
| TM6 | 256 | A | 6.28x28 | PAR1 | 3VW7 | 5-HT1B receptor | 4IAQ |
| TM6 | 257 | V | 6.29x29 | PAR1 | 3VW7 | - | - |
| TM6 | 258 | R | 6.30x30 | PAR1 | 3VW7 | FFA1 receptor | 5TZY |
| TM6 | 259 | A | 6.31x31 | PAR1 | 3VW7 | - | - |
| TM6 | 260 | K | 6.32x32 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM6 | 261 | V | 6.33x33 | PAR1 | 3VW7 | Rhodopsin | 1GZM |
| TM6 | 262 | S | 6.34x34 | PAR1 | 3VW7 | P2Y1 receptor | 4XNW |
| TM6 | 263 | R | 6.35x35 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM6 | 264 | L | 6.36x36 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM6 | 265 | V | 6.37x37 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM6 | 266 | A | 6.38x38 | PAR1 | 3VW7 | PAR2 | 5NDD |
| TM6 | 267 | A | 6.39x39 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM6 | 268 | V | 6.40x40 | PAR1 | 3VW7 | 5-HT2B receptor | 4IB4 |
| TM6 | 269 | V | 6.41x41 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM6 | 270 | L | 6.42x42 | PAR1 | 3VW7 | P2Y1 receptor | 4XNW |
| TM6 | 271 | L | 6.43x43 | PAR1 | 3VW7 | 5-HT2B receptor | 4IB4 |
| TM6 | 272 | F | 6.44x44 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM6 | 273 | A | 6.45x45 | PAR1 | 3VW7 | TP receptor | 6IIV |
| TM6 | 274 | A | 6.46x46 | κ receptor | 6B73 | P2Y1 receptor | 4XNW |
| TM6 | 275 | C | 6.47x47 | κ receptor | 6B73 | κ receptor | 6B73 |
| TM6 | 276 | W | 6.48x48 | PAR1 | 3VW7 | Rhodopsin | 1GZM |
| TM6 | 277 | G | 6.49x49 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM6 | 278 | P | 6.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM6 | 279 | I | 6.51x51 | PAR1 | 3VW7 | κ receptor | 6B73 |
| TM6 | 280 | Q | 6.52x52 | PAR1 | 3VW7 | NOP receptor | 5DHG |
| TM6 | 281 | L | 6.53x53 | PAR1 | 3VW7 | PAR2 | 5NDD |
| TM6 | 282 | F | 6.54x54 | PAR1 | 3VW7 | TP receptor | 6IIV |
| TM6 | 283 | L | 6.55x55 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM6 | 284 | V | 6.56x56 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM6 | 285 | L | 6.57x57 | PAR1 | 3VW7 | GPR52 | 6LI1 |
| TM6 | 286 | Q | 6.58x58 | PAR1 | 3VW7 | NOP receptor | 5DHG |
| TM6 | 287 | A | 6.59x59 | PAR1 | 3VW7 | κ receptor | 6B73 |
| TM6 | 288 | L | 6.60x60 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM6 | 289 | G | 6.61x61 | PAR1 | 3VW7 | NOP receptor | 5DHG |
| ECL3 | 290 | P | - | - | - | - | |
| ECL3 | 291 | A | OX1 receptor | 6TO7 | - | - | |
| ECL3 | 292 | G | OX1 receptor | 6TO7 | - | - | |
| ECL3 | 293 | S | OX1 receptor | 6TO7 | - | - | |
| ECL3 | 294 | W | OX1 receptor | 6TO7 | - | - | |
| ECL3 | 295 | H | OX1 receptor | 6TO7 | - | - | |
| ECL3 | 296 | P | OX1 receptor | 6TO7 | - | - | |
| ECL3 | 297 | R | - | - | - | - | |
| TM7 | 298 | S | 7.28x27 | PAR1 | 3VW7 | TP receptor | 6IIV |
| TM7 | 299 | Y | 7.29x28 | PAR1 | 3VW7 | - | - |
| TM7 | 300 | A | 7.30x29 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM7 | 301 | A | 7.31x30 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM7 | 302 | Y | 7.32x31 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM7 | 303 | A | 7.33x32 | PAR1 | 3VW7 | P2Y1 receptor | 4XNW |
| TM7 | 304 | L | 7.34x33 | PAR1 | 3VW7 | PAR2 | 5NDD |
| TM7 | 305 | K | 7.35x34 | PAR1 | 3VW7 | P2Y12 receptor | 4NTJ |
| TM7 | 306 | T | 7.36x35 | PAR1 | 3VW7 | Rhodopsin | 1GZM |
| TM7 | 307 | W | 7.37x36 | PAR1 | 3VW7 | Rhodopsin | 6I9K |
| TM7 | 308 | A | 7.38x37 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM7 | 309 | H | 7.39x38 | PAR1 | 3VW7 | OX1 receptor | 6TO7 |
| TM7 | 310 | C | 7.40x39 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM7 | 311 | M | 7.41x40 | PAR1 | 3VW7 | MT1 receptor | 6ME2 |
| TM7 | 312 | S | 7.42x41 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM7 | 313 | Y | 7.43x42 | PAR1 | 3VW7 | 5-HT2B receptor | 4IB4 |
| TM7 | 314 | S | 7.44x43 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM7 | 315 | N | 7.45x45 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM7 | 316 | S | 7.46x46 | PAR1 | 3VW7 | P2Y1 receptor | 4XNW |
| TM7 | 317 | A | 7.47x47 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM7 | 318 | L | 7.48x48 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM7 | 319 | N | 7.49x49 | PAR1 | 3VW7 | P2Y1 receptor | 4XNW |
| TM7 | 320 | P | 7.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM7 | 321 | L | 7.51x51 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM7 | 322 | L | 7.52x52 | PAR1 | 3VW7 | P2Y1 receptor | 4XNW |
| TM7 | 323 | Y | 7.53x53 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM7 | 324 | A | 7.54x54 | PAR1 | 3VW7 | MC4 receptor | 6W25 |
| TM7 | 325 | F | 7.55x55 | κ receptor | 6VI4 | κ receptor | 6VI4 |
| TM7 | 326 | L | 7.56x56 | κ receptor | 6VI4 | κ receptor | 6VI4 |
| H8 | 327 | G | 8.47x47 | κ receptor | 6VI4 | κ receptor | 6VI4 |
| H8 | 328 | S | 8.48x48 | κ receptor | 6VI4 | GPR52 | 6LI1 |
| H8 | 329 | H | 8.49x49 | κ receptor | 6VI4 | succinate receptor | 6RNK |
| H8 | 330 | F | 8.50x50 | κ receptor | 6VI4 | PAR2 | 5NDD |
| H8 | 331 | R | 8.51x51 | κ receptor | 6VI4 | PAR2 | 5NDD |
| H8 | 332 | Q | 8.52x52 | κ receptor | 6VI4 | apelin receptor | 5VBL |
| H8 | 333 | A | 8.53x53 | κ receptor | 6VI4 | 5-HT2B receptor | 4IB4 |
| H8 | 334 | F | 8.54x54 | κ receptor | 6VI4 | 5-HT2B receptor | 4IB4 |
| H8 | 335 | R | 8.55x55 | κ receptor | 6VI4 | GPR52 | 6LI1 |
| H8 | 336 | R | 8.56x56 | κ receptor | 6VI4 | 5-HT2B receptor | 4IB4 |
| H8 | 337 | V | 8.57x57 | κ receptor | 6VI4 | AT2 receptor | 6JOD |
| H8 | 338 | C | 8.58x58 | κ receptor | 6VI4 | κ receptor | 6VI4 |
| H8 | 339 | P | 8.59x59 | κ receptor | 6VI4 | - | - |
| C-term | 340 | C | - | - | - | - | |
| C-term | 341 | A | - | - | - | - | |
| C-term | 342 | P | - | - | - | - | |
| C-term | 343 | R | - | - | - | - | |
| C-term | 344 | R | - | - | - | - |