MAS1 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

MAS1

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2020-09-02

MODEL

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PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

PAR2 (sequence similarity: 39%) PDB: 5NDD
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TEMPLATES

5NDD (PAR2)
6D27 (DP2 receptor)
4ZUD (AT1 receptor)
6OS2 (AT1 receptor)
4PXZ (P2Y12 receptor)
4N6H (δ receptor)
6WWZ (CCR6)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 80.4 8.2 11.4
Side-chains 19.2 59.1 21.7

Number of backbone templates: 7
Number of rotamer templates: 48

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 23 A PAR2 5NDD PAR2 5NDD
N-term 24 S PAR2 5NDD PAR2 5NDD
N-term 25 V PAR2 5NDD PAR2 5NDD
N-term 26 G PAR2 5NDD PAR2 5NDD
N-term 27 N PAR2 5NDD PAR2 5NDD
TM1 28 A 1.28x28 PAR2 5NDD CXCR4 3ODU
TM1 29 H 1.29x29 PAR2 5NDD - -
TM1 30 R 1.30x30 PAR2 5NDD - -
TM1 31 Q 1.31x31 PAR2 5NDD P2Y1 receptor 4XNW
TM1 32 I 1.32x32 PAR2 5NDD NK1 receptor 6HLP
TM1 33 P 1.33x33 PAR2 5NDD LPA6 receptor 5XSZ
TM1 34 I 1.34x34 PAR2 5NDD κ receptor 6B73
TM1 35 V 1.35x35 PAR2 5NDD PAR1 3VW7
TM1 36 H 1.36x36 PAR2 5NDD - -
TM1 37 W 1.37x37 PAR2 5NDD TP receptor 6IIV
TM1 38 V 1.38x38 PAR2 5NDD PAR2 5NDD
TM1 39 I 1.39x39 PAR2 5NDD 5-HT2C receptor 6BQH
TM1 40 M 1.40x40 PAR2 5NDD apelin receptor 5VBL
TM1 41 S 1.41x41 PAR2 5NDD TP receptor 6IIV
TM1 42 I 1.42x42 PAR2 5NDD CysLT2 receptor 6RZ6
TM1 43 S 1.43x43 PAR2 5NDD CysLT1 receptor 6RZ4
TM1 44 P 1.44x44 PAR2 5NDD - -
TM1 45 V 1.45x45 PAR2 5NDD PAR2 5NDD
TM1 46 G 1.46x46 PAR2 5NDD CysLT2 receptor 6RZ6
TM1 47 F 1.47x47 PAR2 5NDD CysLT1 receptor 6RZ4
TM1 48 V 1.48x48 PAR2 5NDD DP2 receptor 6D27
TM1 49 E 1.49x49 PAR2 5NDD MC4 receptor 6W25
TM1 50 N 1.50x50 PAR2 5NDD PAR2 5NDD
TM1 51 G 1.51x51 PAR2 5NDD PAR2 5NDD
TM1 52 I 1.52x52 PAR2 5NDD - -
TM1 53 L 1.53x53 PAR2 5NDD Y1 receptor 5ZBH
TM1 54 L 1.54x54 PAR2 5NDD PAR2 5NDD
TM1 55 W 1.55x55 PAR2 5NDD PAR2 5NDD
TM1 56 F 1.56x56 PAR2 5NDD - -
TM1 57 L 1.57x57 PAR2 5NDD CysLT1 receptor 6RZ4
TM1 58 C 1.58x58 PAR2 5NDD AT2 receptor 6JOD
TM1 59 F 1.59x59 PAR2 5NDD PAR2 5NDD
TM1 60 R 1.60x60 PAR2 5NDD PAR2 5NDD
ICL1 61 M - - - -
ICL1 62 R DP2 receptor 6D27 DP2 receptor 6D27
ICL1 63 R - - - -
TM2 64 N 2.37x37 PAR2 5NDD succinate receptor 6RNK
TM2 65 P 2.38x38 PAR2 5NDD PAR2 5NDD
TM2 66 F 2.39x39 PAR2 5NDD CysLT1 receptor 6RZ4
TM2 67 T 2.40x40 PAR2 5NDD LPA6 receptor 5XSZ
TM2 68 V 2.41x41 PAR2 5NDD CysLT2 receptor 6RZ6
TM2 69 Y 2.42x42 PAR2 5NDD PAR2 5NDD
TM2 70 I 2.43x43 PAR2 5NDD MC4 receptor 6W25
TM2 71 T 2.44x44 PAR2 5NDD β2-adrenoceptor 5JQH
TM2 72 H 2.45x45 PAR2 5NDD PAR1 3VW7
TM2 73 L 2.46x46 PAR2 5NDD PAR2 5NDD
TM2 74 S 2.47x47 PAR2 5NDD succinate receptor 6RNK
TM2 75 I 2.48x48 PAR2 5NDD CysLT2 receptor 6RZ6
TM2 76 A 2.49x49 PAR2 5NDD PAR2 5NDD
TM2 77 D 2.50x50 PAR2 5NDD PAR2 5NDD
TM2 78 I 2.51x51 PAR2 5NDD CCR7 6QZH
TM2 79 S 2.52x52 PAR2 5NDD FPR2/ALX 6LW5
TM2 80 L 2.53x53 PAR2 5NDD FFA1 receptor 5TZY
TM2 81 L 2.54x54 PAR2 5NDD succinate receptor 6RNK
TM2 82 F 2.55x55 PAR2 5NDD MT2 receptor 6ME6
TM2 83 C 2.56x56 PAR2 5NDD OX1 receptor 6TO7
TM2 84 I 2.57x57 PAR2 5NDD A2A receptor 4UHR
TM2 85 F 2.58x58 PAR2 5NDD LPA1 receptor 4Z35
TM2 86 I 2.59x59 PAR2 5NDD 5-HT2B receptor 4IB4
TM2 87 L 2.60x60 PAR2 5NDD P2Y1 receptor 4XNW
TM2 88 S 2.61x61 PAR2 5NDD δ receptor 4N6H
TM2 89 I 2.62x62 PAR2 5NDD MC4 receptor 6W25
TM2 90 D 2.63x63 PAR2 5NDD δ receptor 6PT2
TM2 91 Y 2.64x64 PAR2 5NDD CysLT2 receptor 6RZ6
TM2 92 A 2.65x65 PAR2 5NDD succinate receptor 6RNK
TM2 93 L 2.66x66 PAR2 5NDD MC4 receptor 6W25
TM2 94 D 2.67x67 AT1 receptor 4ZUD apelin receptor 5VBL
ECL1 95 Y - - - -
ECL1 96 E - - - -
ECL1 97 L - - - -
TM3 98 S 3.18x18 P2Y12 receptor 4PXZ - -
TM3 99 S 3.19x19 P2Y12 receptor 4PXZ MC4 receptor 6W25
TM3 100 G 3.20x20 P2Y12 receptor 4PXZ - -
TM3 101 H 3.21x21 PAR2 5NDD - -
TM3 102 Y 3.22x22 PAR2 5NDD MT1 receptor 6ME2
TM3 103 Y 3.23x23 PAR2 5NDD AT1 receptor 4ZUD
TM3 104 T 3.24x24 PAR2 5NDD CCR6 6WWZ
TM3 105 I 3.25x25 PAR2 5NDD - -
TM3 106 V 3.26x26 PAR2 5NDD - -
TM3 107 T 3.27x27 PAR2 5NDD NOP receptor 5DHG
TM3 108 L 3.28x28 PAR2 5NDD PAR2 5NDD
TM3 109 S 3.29x29 PAR2 5NDD CysLT2 receptor 6RZ6
TM3 110 V 3.30x30 PAR2 5NDD P2Y12 receptor 4NTJ
TM3 111 T 3.31x31 PAR2 5NDD EP3 receptor 6M9T
TM3 112 F 3.32x32 PAR2 5NDD PAR2 5NDD
TM3 113 L 3.33x33 PAR2 5NDD C5a1 receptor 5O9H
TM3 114 F 3.34x34 PAR2 5NDD P2Y12 receptor 4NTJ
TM3 115 G 3.35x35 PAR2 5NDD CCR5 5UIW
TM3 116 Y 3.36x36 PAR2 5NDD CCR2 5T1A
TM3 117 N 3.37x37 PAR2 5NDD CCR6 6WWZ
TM3 118 T 3.38x38 PAR2 5NDD succinate receptor 6RNK
TM3 119 G 3.39x39 PAR2 5NDD FFA1 receptor 5TZY
TM3 120 L 3.40x40 PAR2 5NDD TP receptor 6IIV
TM3 121 Y 3.41x41 PAR2 5NDD CysLT2 receptor 6RZ6
TM3 122 L 3.42x42 PAR2 5NDD PAR1 3VW7
TM3 123 L 3.43x43 PAR2 5NDD PAR2 5NDD
TM3 124 T 3.44x44 PAR2 5NDD PAR2 5NDD
TM3 125 A 3.45x45 PAR2 5NDD CysLT1 receptor 6RZ4
TM3 126 I 3.46x46 PAR2 5NDD MC4 receptor 6W25
TM3 127 S 3.47x47 PAR2 5NDD PAR2 5NDD
TM3 128 V 3.48x48 PAR2 5NDD PAR2 5NDD
TM3 129 E 3.49x49 PAR2 5NDD TP receptor 6IIV
TM3 130 R 3.50x50 PAR2 5NDD PAR2 5NDD
TM3 131 C 3.51x51 PAR2 5NDD CysLT1 receptor 6RZ4
TM3 132 L 3.52x52 PAR2 5NDD CysLT2 receptor 6RZ6
TM3 133 S 3.53x53 PAR2 5NDD AT2 receptor 6JOD
TM3 134 V 3.54x54 PAR2 5NDD P2Y1 receptor 4XNW
TM3 135 L 3.55x55 PAR2 5NDD FPR2/ALX 6LW5
TM3 136 Y 3.56x56 PAR2 5NDD MC4 receptor 6W25
ICL2 137 P 34.50x50 - - - -
ICL2 138 I 34.51x51 AT1 receptor 6OS2 C5a1 receptor 6C1R
ICL2 139 W 34.52x52 AT1 receptor 6OS2 DP2 receptor 6D27
ICL2 140 Y 34.53x53 AT1 receptor 6OS2 MC4 receptor 6W25
ICL2 141 R 34.54x54 AT1 receptor 6OS2 AT1 receptor 6OS2
ICL2 142 C 34.55x55 AT1 receptor 6OS2 - -
ICL2 143 H 34.56x56 AT1 receptor 6OS2 DP2 receptor 6D27
ICL2 144 R 34.57x57 - - - -
TM4 145 P 4.38x38 PAR2 5NDD - -
TM4 146 K 4.39x39 PAR2 5NDD P2Y1 receptor 4XNW
TM4 147 Y 4.40x40 PAR2 5NDD - -
TM4 148 Q 4.41x41 PAR2 5NDD AT2 receptor 6JOD
TM4 149 S 4.42x42 PAR2 5NDD FFA1 receptor 5TZY
TM4 150 A 4.43x43 PAR2 5NDD apelin receptor 5VBL
TM4 151 L 4.44x44 PAR2 5NDD succinate receptor 6RNK
TM4 152 V 4.45x45 PAR2 5NDD CysLT1 receptor 6RZ4
TM4 153 C 4.46x46 PAR2 5NDD CysLT2 receptor 6RZ6
TM4 154 A 4.47x47 PAR2 5NDD LPA6 receptor 5XSZ
TM4 155 L 4.48x48 PAR2 5NDD P2Y1 receptor 4XNW
TM4 156 L 4.49x49 PAR2 5NDD DP2 receptor 6D27
TM4 157 W 4.50x50 PAR2 5NDD PAR2 5NDD
TM4 158 A 4.51x51 PAR2 5NDD MC4 receptor 6W25
TM4 159 L 4.52x52 PAR2 5NDD PAR2 5NDD
TM4 160 S 4.53x53 PAR2 5NDD 5-HT2B receptor 4IB4
TM4 161 C 4.54x54 PAR2 5NDD AT2 receptor 6JOD
TM4 162 L 4.55x55 PAR2 5NDD PAR2 5NDD
TM4 163 V 4.56x56 PAR2 5NDD PAR2 5NDD
TM4 164 T 4.57x57 δ receptor 4N6H δ receptor 4N6H
TM4 165 T 4.58x58 δ receptor 4N6H - -
TM4 166 M 4.59x59 δ receptor 4N6H apelin receptor 5VBL
TM4 167 E 4.60x60 PAR2 5NDD - -
TM4 168 Y 4.61x61 PAR2 5NDD DP2 receptor 6D27
TM4 169 V 4.62x62 PAR2 5NDD δ receptor 4N6H
TM4 170 M 4.63x63 PAR2 5NDD CysLT1 receptor 6RZ4
TM4 171 C 4.64x64 AT1 receptor 4ZUD - -
ECL2 172 I - - - -
ECL2 173 D - - - -
ECL2 174 R - - - -
ECL2 175 E - - - -
ECL2 176 E - - - -
ECL2 177 E - - - -
ECL2 178 S - - - -
ECL2 179 H - - - -
ECL2 180 S - - - -
ECL2 181 R - - - -
ECL2 182 N - - - -
ECL2 183 D - - - -
ECL2 184 C - - - -
TM5 185 R 5.34x35 PAR2 5NDD DP2 receptor 6D27
TM5 186 A 5.35x36 PAR2 5NDD PAR1 3VW7
TM5 187 V 5.36x37 PAR2 5NDD TP receptor 6IIV
TM5 188 I 5.37x38 PAR2 5NDD P2Y1 receptor 4XNW
TM5 189 I 5.38x39 PAR2 5NDD PAF receptor 5ZKQ
TM5 190 F 5.39x40 PAR2 5NDD PAR2 5NDD
TM5 191 I 5.40x41 PAR2 5NDD MC4 receptor 6W25
TM5 192 A 5.41x42 PAR2 5NDD CCR7 6QZH
TM5 193 I 5.42x43 PAR2 5NDD LPA6 receptor 5XSZ
TM5 194 L 5.43x44 PAR2 5NDD CysLT2 receptor 6RZ6
TM5 195 S 5.44x45 PAR2 5NDD ETB receptor 5X93
TM5 196 F 5.45x46 PAR2 5NDD PAR1 3VW7
TM5 197 L 5.46x461 PAR2 5NDD FFA1 receptor 5TZY
TM5 198 V 5.47x47 PAR2 5NDD A2A receptor 4UHR
TM5 199 F 5.48x48 PAR2 5NDD MC4 receptor 6W25
TM5 200 T 5.49x49 PAR2 5NDD MC4 receptor 6W25
TM5 201 P 5.50x50 PAR2 5NDD PAR2 5NDD
TM5 202 L 5.51x51 PAR2 5NDD MC4 receptor 6W25
TM5 203 M 5.52x52 PAR2 5NDD CCR6 6WWZ
TM5 204 L 5.53x53 PAR2 5NDD PAR2 5NDD
TM5 205 V 5.54x54 PAR2 5NDD P2Y12 receptor 4NTJ
TM5 206 S 5.55x55 PAR2 5NDD CysLT2 receptor 6RZ6
TM5 207 S 5.56x56 PAR2 5NDD PAR2 5NDD
TM5 208 T 5.57x57 PAR2 5NDD 5-HT2B receptor 4IB4
TM5 209 I 5.58x58 PAR2 5NDD - -
TM5 210 L 5.59x59 PAR2 5NDD CysLT2 receptor 6RZ6
TM5 211 V 5.60x60 PAR2 5NDD PAF receptor 5ZKQ
TM5 212 V 5.61x61 PAR2 5NDD LPA6 receptor 5XSZ
TM5 213 K 5.62x62 PAR2 5NDD - -
TM5 214 I 5.63x63 PAR2 5NDD NK1 receptor 6HLP
TM5 215 R 5.64x64 PAR2 5NDD DP2 receptor 6D27
TM5 216 K 5.65x65 PAR2 5NDD - -
TM5 217 N 5.66x66 AT1 receptor 6OS2 - -
TM5 218 T 5.67x67 AT1 receptor 6OS2 S1P1 receptor 3V2Y
TM5 219 W 5.68x68 AT1 receptor 6OS2 D4 receptor 5WIV
ICL3 220 A - - - -
ICL3 221 S - - - -
ICL3 222 H - - - -
TM6 223 S 6.30x30 PAR2 5NDD CysLT2 receptor 6RZ6
TM6 224 S 6.31x31 PAR2 5NDD FPR2/ALX 6OMM
TM6 225 K 6.32x32 PAR2 5NDD PAR2 5NDD
TM6 226 L 6.33x33 PAR2 5NDD apelin receptor 5VBL
TM6 227 Y 6.34x34 PAR2 5NDD - -
TM6 228 I 6.35x35 PAR2 5NDD PAR2 5NDD
TM6 229 V 6.36x36 PAR2 5NDD P2Y12 receptor 4PXZ
TM6 230 I 6.37x37 PAR2 5NDD LPA6 receptor 5XSZ
TM6 231 M 6.38x38 PAR2 5NDD AT1 receptor 4ZUD
TM6 232 V 6.39x39 PAR2 5NDD PAR2 5NDD
TM6 233 T 6.40x40 PAR2 5NDD PAR2 5NDD
TM6 234 I 6.41x41 PAR2 5NDD MC4 receptor 6W25
TM6 235 I 6.42x42 PAR2 5NDD P2Y12 receptor 4NTJ
TM6 236 I 6.43x43 PAR2 5NDD CysLT2 receptor 6RZ6
TM6 237 F 6.44x44 PAR2 5NDD MC4 receptor 6W25
TM6 238 L 6.45x45 PAR2 5NDD FFA1 receptor 5TZY
TM6 239 I 6.46x46 AT1 receptor 4ZUD PAR1 3VW7
TM6 240 F 6.47x47 AT1 receptor 4ZUD CCR7 6QZH
TM6 241 A 6.48x48 PAR2 5NDD - -
TM6 242 M 6.49x49 PAR2 5NDD CysLT1 receptor 6RZ4
TM6 243 P 6.50x50 PAR2 5NDD PAR2 5NDD
TM6 244 M 6.51x51 PAR2 5NDD - -
TM6 245 R 6.52x52 PAR2 5NDD - -
TM6 246 L 6.53x53 PAR2 5NDD PAR2 5NDD
TM6 247 L 6.54x54 PAR2 5NDD PAR2 5NDD
TM6 248 Y 6.55x55 PAR2 5NDD α2C-adrenoceptor 6KUW
TM6 249 L 6.56x56 PAR2 5NDD PAF receptor 5ZKQ
TM6 250 L 6.57x57 PAR2 5NDD AT1 receptor 4ZUD
TM6 251 Y 6.58x58 PAR2 5NDD MC4 receptor 6W25
TM6 252 Y 6.59x59 PAR2 5NDD PAR2 5NDD
TM6 253 E 6.60x60 PAR2 5NDD - -
TM6 254 Y 6.61x61 PAR2 5NDD - -
ECL3 255 W - - - -
ECL3 256 S - - - -
ECL3 257 T - - - -
ECL3 258 F - - - -
TM7 259 G 7.32x31 PAR2 5NDD FFA1 receptor 5TZY
TM7 260 N 7.33x32 PAR2 5NDD apelin receptor 5VBL
TM7 261 L 7.34x33 PAR2 5NDD PAR2 5NDD
TM7 262 H 7.35x34 PAR2 5NDD PAF receptor 5ZKQ
TM7 263 H 7.36x35 PAR2 5NDD δ receptor 4N6H
TM7 264 I 7.37x36 PAR2 5NDD CysLT2 receptor 6RZ6
TM7 265 S 7.38x37 PAR2 5NDD MT2 receptor 6ME6
TM7 266 L 7.39x38 PAR2 5NDD PAR2 5NDD
TM7 267 L 7.40x39 PAR2 5NDD AT2 receptor 6JOD
TM7 268 F 7.41x40 PAR2 5NDD C5a1 receptor 5O9H
TM7 269 S 7.42x41 PAR2 5NDD PAR2 5NDD
TM7 270 T 7.43x42 PAR2 5NDD PAR2 5NDD
TM7 271 I 7.44x43 PAR2 5NDD PAR1 3VW7
TM7 272 N 7.45x45 PAR2 5NDD PAR2 5NDD
TM7 273 S 7.46x46 PAR2 5NDD PAR2 5NDD
TM7 274 S 7.47x47 PAR2 5NDD δ receptor 4N6H
TM7 275 A 7.48x48 PAR2 5NDD DP2 receptor 6D27
TM7 276 N 7.49x49 PAR2 5NDD CysLT2 receptor 6RZ6
TM7 277 P 7.50x50 PAR2 5NDD PAR2 5NDD
TM7 278 F 7.51x51 PAR2 5NDD PAR2 5NDD
TM7 279 I 7.52x52 PAR2 5NDD MC4 receptor 6W25
TM7 280 Y 7.53x53 PAR2 5NDD PAR2 5NDD
TM7 281 F 7.54x54 PAR2 5NDD CysLT1 receptor 6RZ5
TM7 282 F 7.55x55 PAR2 5NDD PAR2 5NDD
TM7 283 V 7.56x56 PAR2 5NDD PAR2 5NDD
H8 284 G 8.47x47 PAR2 5NDD AT1 receptor 6OS2
H8 285 S 8.48x48 PAR2 5NDD GPR52 6LI1
H8 286 S 8.49x49 PAR2 5NDD P2Y12 receptor 4NTJ
H8 287 K 8.50x50 PAR2 5NDD - -
H8 288 K 8.51x51 PAR2 5NDD CysLT2 receptor 6RZ6
H8 289 K 8.52x52 PAR2 5NDD MC4 receptor 6W25
H8 290 R 8.53x53 PAR2 5NDD CysLT2 receptor 6RZ6
H8 291 F 8.54x54 PAR2 5NDD MC4 receptor 6W25
H8 292 K 8.55x55 PAR2 5NDD PAR2 5NDD
H8 293 E 8.56x56 PAR2 5NDD MC4 receptor 6W25
H8 294 S 8.57x57 PAR2 5NDD DP2 receptor 6D27
H8 295 L 8.58x58 PAR2 5NDD PAR2 5NDD
H8 296 K 8.59x59 CCR6 6WWZ CCR6 6WWZ
H8 297 V 8.60x60 CCR6 6WWZ - -
H8 298 V 8.61x61 CCR6 6WWZ DP2 receptor 6D27
C-term 299 L - - - -
C-term 300 T - - - -
C-term 301 R - - - -
C-term 302 A - - - -
C-term 303 F - - - -