MRGPRX2 homology model
PROTEIN CLASS
Class A (Rhodopsin)
RECEPTOR
SPECIES
Homo sapiens
STATE
Intermediate
VERSION
2021-01-08
MODEL
TEMPLATES
5NDD (PAR2)
5O9H (C5a1 receptor)
4XNW (P2Y1 receptor)
6D27 (DP2 receptor)
5TGZ (CB1 receptor)
None
5O9H (C5a1 receptor)
4XNW (P2Y1 receptor)
6D27 (DP2 receptor)
5TGZ (CB1 receptor)
None
| Main template (%) | Additional templates (%) | No template - freely modelled (%) | |
|---|---|---|---|
| Backbone | 81.2 | 10.5 | 8.3 |
| Side-chains | 17.4 | 60.9 | 21.7 |
Number of backbone templates: 5
Number of rotamer templates: 41
| Segment | Seq.num. | AA | GPCRdb# | Backbone | PDB | Rotamer | PDB |
|---|---|---|---|---|---|---|---|
| N-term | 22 | L | PAR2 | 5NDD | PAR2 | 5NDD | |
| N-term | 23 | L | PAR2 | 5NDD | PAR2 | 5NDD | |
| N-term | 24 | L | PAR2 | 5NDD | PAR2 | 5NDD | |
| N-term | 25 | L | PAR2 | 5NDD | PAR2 | 5NDD | |
| N-term | 26 | C | PAR2 | 5NDD | PAR2 | 5NDD | |
| TM1 | 27 | G | 1.29x29 | PAR2 | 5NDD | CB2 receptor | 5ZTY |
| TM1 | 28 | K | 1.30x30 | PAR2 | 5NDD | - | - |
| TM1 | 29 | E | 1.31x31 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM1 | 30 | T | 1.32x32 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 31 | L | 1.33x33 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM1 | 32 | I | 1.34x34 | PAR2 | 5NDD | κ receptor | 6B73 |
| TM1 | 33 | P | 1.35x35 | PAR2 | 5NDD | FPR2/ALX | 6LW5 |
| TM1 | 34 | V | 1.36x36 | PAR2 | 5NDD | DP2 receptor | 6D27 |
| TM1 | 35 | F | 1.37x37 | PAR2 | 5NDD | US28 | 5WB1 |
| TM1 | 36 | L | 1.38x38 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM1 | 37 | I | 1.39x39 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM1 | 38 | L | 1.40x40 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM1 | 39 | F | 1.41x41 | PAR2 | 5NDD | MT1 receptor | 6ME2 |
| TM1 | 40 | I | 1.42x42 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM1 | 41 | A | 1.43x43 | PAR2 | 5NDD | A1 receptor | 5UEN |
| TM1 | 42 | L | 1.44x44 | PAR2 | 5NDD | C5a1 receptor | 5O9H |
| TM1 | 43 | V | 1.45x45 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 44 | G | 1.46x46 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM1 | 45 | L | 1.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 46 | V | 1.48x48 | PAR2 | 5NDD | DP2 receptor | 6D27 |
| TM1 | 47 | G | 1.49x49 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM1 | 48 | N | 1.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 49 | G | 1.51x51 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 50 | F | 1.52x52 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM1 | 51 | V | 1.53x53 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM1 | 52 | L | 1.54x54 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 53 | W | 1.55x55 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 54 | L | 1.56x56 | PAR2 | 5NDD | AT2 receptor | 6JOD |
| TM1 | 55 | L | 1.57x57 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM1 | 56 | G | 1.58x58 | PAR2 | 5NDD | DP2 receptor | 6D27 |
| TM1 | 57 | F | 1.59x59 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 58 | R | 1.60x60 | PAR2 | 5NDD | PAR2 | 5NDD |
| ICL1 | 59 | M | - | - | - | - | |
| ICL1 | 60 | R | C5a1 receptor | 5O9H | - | - | |
| ICL1 | 61 | R | - | - | - | - | |
| TM2 | 62 | N | 2.37x37 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM2 | 63 | A | 2.38x38 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM2 | 64 | F | 2.39x39 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM2 | 65 | S | 2.40x40 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM2 | 66 | V | 2.41x41 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM2 | 67 | Y | 2.42x42 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 68 | V | 2.43x43 | PAR2 | 5NDD | DP2 receptor | 6D27 |
| TM2 | 69 | L | 2.44x44 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM2 | 70 | S | 2.45x45 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM2 | 71 | L | 2.46x46 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 72 | A | 2.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 73 | G | 2.48x48 | PAR2 | 5NDD | CB2 receptor | 6PT0 |
| TM2 | 74 | A | 2.49x49 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 75 | D | 2.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 76 | F | 2.51x51 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM2 | 77 | L | 2.52x52 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 78 | F | 2.53x53 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM2 | 79 | L | 2.54x54 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM2 | 80 | C | 2.55x55 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM2 | 81 | F | 2.56x56 | PAR2 | 5NDD | NK1 receptor | 6HLP |
| TM2 | 82 | Q | 2.57x57 | PAR2 | 5NDD | - | - |
| TM2 | 83 | I | 2.58x58 | PAR2 | 5NDD | - | - |
| TM2 | 84 | I | 2.59x59 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM2 | 85 | N | 2.60x60 | PAR2 | 5NDD | H1 receptor | 3RZE |
| TM2 | 86 | C | 2.61x61 | PAR2 | 5NDD | - | - |
| TM2 | 87 | L | 2.62x62 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM2 | 88 | V | 2.63x63 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM2 | 89 | Y | 2.64x64 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM2 | 90 | L | 2.65x65 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM2 | 91 | S | 2.66x66 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM2 | 92 | N | 2.67x67 | C5a1 receptor | 5O9H | κ receptor | 6B73 |
| ECL1 | 93 | F | - | - | - | - | |
| ECL1 | 94 | F | C5a1 receptor | 5O9H | - | - | |
| ECL1 | 95 | C | C5a1 receptor | 5O9H | - | - | |
| ECL1 | 96 | S | C5a1 receptor | 5O9H | - | - | |
| ECL1 | 97 | I | - | - | - | - | |
| TM3 | 98 | S | 3.21x21 | PAR2 | 5NDD | CB1 receptor | 5TGZ |
| TM3 | 99 | I | 3.22x22 | PAR2 | 5NDD | - | - |
| TM3 | 100 | N | 3.23x23 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM3 | 101 | F | 3.24x24 | PAR2 | 5NDD | DP2 receptor | 6D27 |
| TM3 | 102 | P | 3.25x25 | PAR2 | 5NDD | - | - |
| TM3 | 103 | S | 3.26x26 | PAR2 | 5NDD | C5a1 receptor | 5O9H |
| TM3 | 104 | F | 3.27x27 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM3 | 105 | F | 3.28x28 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM3 | 106 | T | 3.29x29 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM3 | 107 | T | 3.30x30 | PAR2 | 5NDD | D2 receptor | 6CM4 |
| TM3 | 108 | V | 3.31x31 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM3 | 109 | M | 3.32x32 | PAR2 | 5NDD | TP receptor | 6IIV |
| TM3 | 110 | T | 3.33x33 | PAR2 | 5NDD | CB1 receptor | 5TGZ |
| TM3 | 111 | C | 3.34x34 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM3 | 112 | A | 3.35x35 | PAR2 | 5NDD | US28 | 5WB1 |
| TM3 | 113 | Y | 3.36x36 | PAR2 | 5NDD | CCR2 | 5T1A |
| TM3 | 114 | L | 3.37x37 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM3 | 115 | A | 3.38x38 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM3 | 116 | G | 3.39x39 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM3 | 117 | L | 3.40x40 | PAR2 | 5NDD | TP receptor | 6IIV |
| TM3 | 118 | S | 3.41x41 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM3 | 119 | M | 3.42x42 | PAR2 | 5NDD | GnRH1 receptor | 7BR3 |
| TM3 | 120 | L | 3.43x43 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 121 | S | 3.44x44 | PAR2 | 5NDD | DP2 receptor | 6D27 |
| TM3 | 122 | T | 3.45x45 | PAR2 | 5NDD | C5a1 receptor | 5O9H |
| TM3 | 123 | V | 3.46x46 | PAR2 | 5NDD | NK1 receptor | 6HLP |
| TM3 | 124 | S | 3.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 125 | T | 3.48x48 | PAR2 | 5NDD | - | - |
| TM3 | 126 | E | 3.49x49 | PAR2 | 5NDD | TP receptor | 6IIV |
| TM3 | 127 | R | 3.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 128 | C | 3.51x51 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM3 | 129 | L | 3.52x52 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM3 | 130 | S | 3.53x53 | PAR2 | 5NDD | CB1 receptor | 5TGZ |
| TM3 | 131 | V | 3.54x54 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM3 | 132 | L | 3.55x55 | PAR2 | 5NDD | FPR2/ALX | 6LW5 |
| TM3 | 133 | W | 3.56x56 | PAR2 | 5NDD | - | - |
| ICL2 | 134 | P | 34.50x50 | - | - | - | - |
| ICL2 | 135 | I | 34.51x51 | C5a1 receptor | 5O9H | C5a1 receptor | 6C1R |
| ICL2 | 136 | W | 34.52x52 | C5a1 receptor | 5O9H | C5a1 receptor | 5O9H |
| ICL2 | 137 | Y | 34.53x53 | C5a1 receptor | 5O9H | MC4 receptor | 6W25 |
| ICL2 | 138 | R | 34.54x54 | C5a1 receptor | 5O9H | LPA6 receptor | 5XSZ |
| ICL2 | 139 | C | 34.55x55 | C5a1 receptor | 5O9H | - | - |
| ICL2 | 140 | R | 34.56x56 | C5a1 receptor | 5O9H | P2Y1 receptor | 4XNW |
| ICL2 | 141 | R | 34.57x57 | - | - | - | - |
| TM4 | 142 | P | 4.38x38 | PAR2 | 5NDD | - | - |
| TM4 | 143 | R | 4.39x39 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM4 | 144 | H | 4.40x40 | PAR2 | 5NDD | - | - |
| TM4 | 145 | L | 4.41x41 | PAR2 | 5NDD | C5a1 receptor | 5O9H |
| TM4 | 146 | S | 4.42x42 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM4 | 147 | A | 4.43x43 | PAR2 | 5NDD | apelin receptor | 5VBL |
| TM4 | 148 | V | 4.44x44 | PAR2 | 5NDD | AT1 receptor | 4ZUD |
| TM4 | 149 | V | 4.45x45 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM4 | 150 | C | 4.46x46 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM4 | 151 | V | 4.47x47 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM4 | 152 | L | 4.48x48 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM4 | 153 | L | 4.49x49 | PAR2 | 5NDD | DP2 receptor | 6D27 |
| TM4 | 154 | W | 4.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 155 | A | 4.51x51 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM4 | 156 | L | 4.52x52 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 157 | S | 4.53x53 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM4 | 158 | L | 4.54x54 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 159 | L | 4.55x55 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 160 | L | 4.56x56 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM4 | 161 | S | 4.57x57 | P2Y1 receptor | 4XNW | CysLT1 receptor | 6RZ4 |
| TM4 | 162 | I | 4.58x58 | P2Y1 receptor | 4XNW | MC4 receptor | 6W25 |
| TM4 | 163 | L | 4.59x59 | P2Y1 receptor | 4XNW | MC4 receptor | 6W25 |
| TM4 | 164 | E | 4.60x60 | PAR2 | 5NDD | - | - |
| TM4 | 165 | G | 4.61x61 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM4 | 166 | K | 4.62x62 | PAR2 | 5NDD | - | - |
| TM4 | 167 | F | 4.63x63 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM4 | 168 | C | 4.64x64 | C5a1 receptor | 5O9H | - | - |
| ECL2 | 169 | G | - | - | - | - | |
| ECL2 | 170 | F | - | - | - | - | |
| ECL2 | 171 | L | - | - | - | - | |
| ECL2 | 172 | F | - | - | - | - | |
| ECL2 | 173 | S | - | - | - | - | |
| ECL2 | 174 | D | - | - | - | - | |
| ECL2 | 175 | G | - | - | - | - | |
| ECL2 | 176 | D | - | - | - | - | |
| TM5 | 177 | S | 5.31x31 | DP2 receptor | 6D27 | apelin receptor | 5VBL |
| TM5 | 178 | G | 5.32x32 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM5 | 179 | W | 5.33x33 | PAR2 | 5NDD | apelin receptor | 5VBL |
| TM5 | 180 | C | 5.34x34 | PAR2 | 5NDD | - | - |
| TM5 | 181 | Q | 5.35x35 | PAR2 | 5NDD | - | - |
| TM5 | 182 | T | 5.36x36 | PAR2 | 5NDD | - | - |
| TM5 | 183 | F | 5.37x37 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 184 | D | 5.38x38 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM5 | 185 | F | 5.39x39 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM5 | 186 | I | 5.40x40 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM5 | 187 | T | 5.41x41 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM5 | 188 | A | 5.42x42 | PAR2 | 5NDD | CCR7 | 6QZH |
| TM5 | 189 | A | 5.43x43 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM5 | 190 | W | 5.44x44 | PAR2 | 5NDD | - | - |
| TM5 | 191 | L | 5.45x45 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM5 | 192 | I | 5.46x46 | CB1 receptor | 5TGZ | P2Y12 receptor | 4NTJ |
| TM5 | 193 | F | 5.47x47 | CB1 receptor | 5TGZ | PAR2 | 5NDD |
| TM5 | 194 | L | 5.48x48 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 195 | F | 5.49x49 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 196 | M | 5.50x50 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM5 | 197 | V | 5.51x51 | PAR2 | 5NDD | TP receptor | 6IIV |
| TM5 | 198 | L | 5.52x52 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM5 | 199 | C | 5.53x53 | PAR2 | 5NDD | ghrelin receptor | 6KO5 |
| TM5 | 200 | G | 5.54x54 | PAR2 | 5NDD | - | - |
| TM5 | 201 | S | 5.55x55 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM5 | 202 | S | 5.56x56 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 203 | L | 5.57x57 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM5 | 204 | A | 5.58x58 | PAR2 | 5NDD | - | - |
| TM5 | 205 | L | 5.59x59 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM5 | 206 | L | 5.60x60 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 207 | V | 5.61x61 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM5 | 208 | R | 5.62x62 | PAR2 | 5NDD | AT2 receptor | 6JOD |
| TM5 | 209 | I | 5.63x63 | PAR2 | 5NDD | NK1 receptor | 6HLP |
| TM5 | 210 | L | 5.64x64 | PAR2 | 5NDD | A1 receptor | 5UEN |
| TM5 | 211 | C | 5.65x65 | PAR2 | 5NDD | - | - |
| TM5 | 212 | G | 5.66x66 | C5a1 receptor | 5O9H | - | - |
| TM5 | 213 | S | 5.67x67 | C5a1 receptor | 5O9H | C5a1 receptor | 5O9H |
| TM5 | 214 | R | 5.68x68 | C5a1 receptor | 5O9H | succinate receptor | 6IBB |
| ICL3 | 215 | G | - | - | - | - | |
| ICL3 | 216 | L | - | - | - | - | |
| ICL3 | 217 | P | - | - | - | - | |
| TM6 | 218 | L | 6.30x30 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM6 | 219 | T | 6.31x31 | PAR2 | 5NDD | C5a1 receptor | 6C1R |
| TM6 | 220 | R | 6.32x32 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM6 | 221 | L | 6.33x33 | PAR2 | 5NDD | apelin receptor | 5VBL |
| TM6 | 222 | Y | 6.34x34 | PAR2 | 5NDD | - | - |
| TM6 | 223 | L | 6.35x35 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM6 | 224 | T | 6.36x36 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM6 | 225 | I | 6.37x37 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM6 | 226 | L | 6.38x38 | PAR2 | 5NDD | μ receptor | 5C1M |
| TM6 | 227 | L | 6.39x39 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM6 | 228 | T | 6.40x40 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 229 | V | 6.41x41 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 230 | L | 6.42x42 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM6 | 231 | V | 6.43x43 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM6 | 232 | F | 6.44x44 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM6 | 233 | L | 6.45x45 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM6 | 234 | L | 6.46x46 | C5a1 receptor | 5O9H | PAR2 | 5NDD |
| TM6 | 235 | C | 6.47x47 | C5a1 receptor | 5O9H | PAR2 | 5NDD |
| TM6 | 236 | G | 6.48x48 | PAR2 | 5NDD | - | - |
| TM6 | 237 | L | 6.49x49 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM6 | 238 | P | 6.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 239 | F | 6.51x51 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM6 | 240 | G | 6.52x52 | PAR2 | 5NDD | - | - |
| TM6 | 241 | I | 6.53x53 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM6 | 242 | Q | 6.54x54 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM6 | 243 | W | 6.55x55 | PAR2 | 5NDD | - | - |
| TM6 | 244 | F | 6.56x56 | PAR2 | 5NDD | AT1 receptor | 4ZUD |
| TM6 | 245 | L | 6.57x57 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM6 | 246 | I | 6.58x58 | PAR2 | 5NDD | H1 receptor | 3RZE |
| TM6 | 247 | L | 6.59x59 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM6 | 248 | W | 6.60x60 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM6 | 249 | I | 6.61x61 | PAR2 | 5NDD | AT1 receptor | 4ZUD |
| ECL3 | 250 | W | - | - | - | - | |
| TM7 | 251 | K | 7.25x24 | C5a1 receptor | 5O9H | - | - |
| TM7 | 252 | D | 7.26x25 | C5a1 receptor | 5O9H | CysLT1 receptor | 6RZ4 |
| TM7 | 253 | S | 7.27x26 | C5a1 receptor | 5O9H | CysLT1 receptor | 6RZ4 |
| TM7 | 254 | D | 7.28x27 | C5a1 receptor | 5O9H | apelin receptor | 5VBL |
| TM7 | 255 | V | 7.29x28 | C5a1 receptor | 5O9H | - | - |
| TM7 | 256 | L | 7.30x29 | C5a1 receptor | 5O9H | C5a1 receptor | 5O9H |
| TM7 | 257 | F | 7.31x30 | PAR2 | 5NDD | - | - |
| TM7 | 258 | C | 7.32x31 | PAR2 | 5NDD | EP3 receptor | 6M9T |
| TM7 | 259 | H | 7.33x32 | PAR2 | 5NDD | H1 receptor | 3RZE |
| TM7 | 260 | I | 7.34x33 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM7 | 261 | H | 7.35x34 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM7 | 262 | P | 7.36x35 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM7 | 263 | V | 7.37x36 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 264 | S | 7.38x37 | PAR2 | 5NDD | ghrelin receptor | 6KO5 |
| TM7 | 265 | V | 7.39x38 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM7 | 266 | V | 7.40x39 | PAR2 | 5NDD | CCR6 | 6WWZ |
| TM7 | 267 | L | 7.41x40 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 268 | S | 7.42x41 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 269 | S | 7.43x42 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM7 | 270 | L | 7.44x43 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 271 | N | 7.45x45 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 272 | S | 7.46x46 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 273 | S | 7.47x47 | PAR2 | 5NDD | κ receptor | 6B73 |
| TM7 | 274 | A | 7.48x48 | PAR2 | 5NDD | DP2 receptor | 6D27 |
| TM7 | 275 | N | 7.49x49 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM7 | 276 | P | 7.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 277 | I | 7.51x51 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM7 | 278 | I | 7.52x52 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM7 | 279 | Y | 7.53x53 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 280 | F | 7.54x54 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM7 | 281 | F | 7.55x55 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 282 | V | 7.56x56 | PAR2 | 5NDD | PAR2 | 5NDD |
| H8 | 283 | G | 8.47x47 | PAR2 | 5NDD | AT1 receptor | 6OS2 |
| H8 | 284 | S | 8.48x48 | PAR2 | 5NDD | GPR52 | 6LI1 |
| H8 | 285 | F | 8.49x49 | PAR2 | 5NDD | - | - |
| H8 | 286 | R | 8.50x50 | PAR2 | 5NDD | - | - |
| H8 | 287 | K | 8.51x51 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| H8 | 288 | Q | 8.52x52 | PAR2 | 5NDD | apelin receptor | 5VBL |
| H8 | 289 | W | 8.53x53 | PAR2 | 5NDD | - | - |
| H8 | 290 | R | 8.54x54 | PAR2 | 5NDD | - | - |
| H8 | 291 | L | 8.55x55 | PAR2 | 5NDD | AT1 receptor | 6OS2 |
| H8 | 292 | Q | 8.56x56 | PAR2 | 5NDD | AT1 receptor | 6OS2 |
| C-term | 293 | Q | - | - | - | - | |
| C-term | 294 | P | - | - | - | - | |
| C-term | 295 | I | - | - | - | - | |
| C-term | 296 | L | - | - | - | - | |
| C-term | 297 | K | - | - | - | - |