MRGPRX2 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-01-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

PAR2 (sequence similarity: 40%) PDB: 5NDD

TEMPLATES

5NDD (PAR2)
5O9H (C5a1 receptor)
4XNW (P2Y1 receptor)
6D27 (DP2 receptor)
5TGZ (CB1 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 81.2 10.5 8.3
Side-chains 17.4 60.9 21.7

Number of backbone templates: 5
Number of rotamer templates: 41

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 22 L PAR2 5NDD PAR2 5NDD
N-term 23 L PAR2 5NDD PAR2 5NDD
N-term 24 L PAR2 5NDD PAR2 5NDD
N-term 25 L PAR2 5NDD PAR2 5NDD
N-term 26 C PAR2 5NDD PAR2 5NDD
TM1 27 G 1.29x29 PAR2 5NDD CB2 receptor 5ZTY
TM1 28 K 1.30x30 PAR2 5NDD - -
TM1 29 E 1.31x31 PAR2 5NDD succinate receptor 6RNK
TM1 30 T 1.32x32 PAR2 5NDD PAR2 5NDD
TM1 31 L 1.33x33 PAR2 5NDD PAR1 3VW7
TM1 32 I 1.34x34 PAR2 5NDD κ receptor 6B73
TM1 33 P 1.35x35 PAR2 5NDD FPR2/ALX 6LW5
TM1 34 V 1.36x36 PAR2 5NDD DP2 receptor 6D27
TM1 35 F 1.37x37 PAR2 5NDD US28 5WB1
TM1 36 L 1.38x38 PAR2 5NDD CysLT1 receptor 6RZ4
TM1 37 I 1.39x39 PAR2 5NDD GPR52 6LI1
TM1 38 L 1.40x40 PAR2 5NDD CysLT2 receptor 6RZ6
TM1 39 F 1.41x41 PAR2 5NDD MT1 receptor 6ME2
TM1 40 I 1.42x42 PAR2 5NDD CysLT1 receptor 6RZ4
TM1 41 A 1.43x43 PAR2 5NDD A1 receptor 5UEN
TM1 42 L 1.44x44 PAR2 5NDD C5a1 receptor 5O9H
TM1 43 V 1.45x45 PAR2 5NDD PAR2 5NDD
TM1 44 G 1.46x46 PAR2 5NDD CysLT1 receptor 6RZ4
TM1 45 L 1.47x47 PAR2 5NDD PAR2 5NDD
TM1 46 V 1.48x48 PAR2 5NDD DP2 receptor 6D27
TM1 47 G 1.49x49 PAR2 5NDD CysLT1 receptor 6RZ4
TM1 48 N 1.50x50 PAR2 5NDD PAR2 5NDD
TM1 49 G 1.51x51 PAR2 5NDD PAR2 5NDD
TM1 50 F 1.52x52 PAR2 5NDD CysLT1 receptor 6RZ4
TM1 51 V 1.53x53 PAR2 5NDD CysLT1 receptor 6RZ4
TM1 52 L 1.54x54 PAR2 5NDD PAR2 5NDD
TM1 53 W 1.55x55 PAR2 5NDD PAR2 5NDD
TM1 54 L 1.56x56 PAR2 5NDD AT2 receptor 6JOD
TM1 55 L 1.57x57 PAR2 5NDD CysLT1 receptor 6RZ4
TM1 56 G 1.58x58 PAR2 5NDD DP2 receptor 6D27
TM1 57 F 1.59x59 PAR2 5NDD PAR2 5NDD
TM1 58 R 1.60x60 PAR2 5NDD PAR2 5NDD
ICL1 59 M - - - -
ICL1 60 R C5a1 receptor 5O9H - -
ICL1 61 R - - - -
TM2 62 N 2.37x37 PAR2 5NDD LPA6 receptor 5XSZ
TM2 63 A 2.38x38 PAR2 5NDD CysLT1 receptor 6RZ4
TM2 64 F 2.39x39 PAR2 5NDD CysLT1 receptor 6RZ4
TM2 65 S 2.40x40 PAR2 5NDD P2Y1 receptor 4XNW
TM2 66 V 2.41x41 PAR2 5NDD CysLT1 receptor 6RZ4
TM2 67 Y 2.42x42 PAR2 5NDD PAR2 5NDD
TM2 68 V 2.43x43 PAR2 5NDD DP2 receptor 6D27
TM2 69 L 2.44x44 PAR2 5NDD CysLT2 receptor 6RZ6
TM2 70 S 2.45x45 PAR2 5NDD MC4 receptor 6W25
TM2 71 L 2.46x46 PAR2 5NDD PAR2 5NDD
TM2 72 A 2.47x47 PAR2 5NDD PAR2 5NDD
TM2 73 G 2.48x48 PAR2 5NDD CB2 receptor 6PT0
TM2 74 A 2.49x49 PAR2 5NDD PAR2 5NDD
TM2 75 D 2.50x50 PAR2 5NDD PAR2 5NDD
TM2 76 F 2.51x51 PAR2 5NDD P2Y1 receptor 4XNW
TM2 77 L 2.52x52 PAR2 5NDD PAR2 5NDD
TM2 78 F 2.53x53 PAR2 5NDD LPA6 receptor 5XSZ
TM2 79 L 2.54x54 PAR2 5NDD succinate receptor 6RNK
TM2 80 C 2.55x55 PAR2 5NDD CysLT1 receptor 6RZ4
TM2 81 F 2.56x56 PAR2 5NDD NK1 receptor 6HLP
TM2 82 Q 2.57x57 PAR2 5NDD - -
TM2 83 I 2.58x58 PAR2 5NDD - -
TM2 84 I 2.59x59 PAR2 5NDD 5-HT2B receptor 4IB4
TM2 85 N 2.60x60 PAR2 5NDD H1 receptor 3RZE
TM2 86 C 2.61x61 PAR2 5NDD - -
TM2 87 L 2.62x62 PAR2 5NDD P2Y12 receptor 4NTJ
TM2 88 V 2.63x63 PAR2 5NDD MC4 receptor 6W25
TM2 89 Y 2.64x64 PAR2 5NDD CysLT1 receptor 6RZ4
TM2 90 L 2.65x65 PAR2 5NDD CysLT2 receptor 6RZ6
TM2 91 S 2.66x66 PAR2 5NDD PAR1 3VW7
TM2 92 N 2.67x67 C5a1 receptor 5O9H κ receptor 6B73
ECL1 93 F - - - -
ECL1 94 F C5a1 receptor 5O9H - -
ECL1 95 C C5a1 receptor 5O9H - -
ECL1 96 S C5a1 receptor 5O9H - -
ECL1 97 I - - - -
TM3 98 S 3.21x21 PAR2 5NDD CB1 receptor 5TGZ
TM3 99 I 3.22x22 PAR2 5NDD - -
TM3 100 N 3.23x23 PAR2 5NDD MC4 receptor 6W25
TM3 101 F 3.24x24 PAR2 5NDD DP2 receptor 6D27
TM3 102 P 3.25x25 PAR2 5NDD - -
TM3 103 S 3.26x26 PAR2 5NDD C5a1 receptor 5O9H
TM3 104 F 3.27x27 PAR2 5NDD PAR1 3VW7
TM3 105 F 3.28x28 PAR2 5NDD GPR52 6LI1
TM3 106 T 3.29x29 PAR2 5NDD CysLT1 receptor 6RZ4
TM3 107 T 3.30x30 PAR2 5NDD D2 receptor 6CM4
TM3 108 V 3.31x31 PAR2 5NDD MC4 receptor 6W25
TM3 109 M 3.32x32 PAR2 5NDD TP receptor 6IIV
TM3 110 T 3.33x33 PAR2 5NDD CB1 receptor 5TGZ
TM3 111 C 3.34x34 PAR2 5NDD PAR1 3VW7
TM3 112 A 3.35x35 PAR2 5NDD US28 5WB1
TM3 113 Y 3.36x36 PAR2 5NDD CCR2 5T1A
TM3 114 L 3.37x37 PAR2 5NDD MC4 receptor 6W25
TM3 115 A 3.38x38 PAR2 5NDD PAR1 3VW7
TM3 116 G 3.39x39 PAR2 5NDD FFA1 receptor 5TZY
TM3 117 L 3.40x40 PAR2 5NDD TP receptor 6IIV
TM3 118 S 3.41x41 PAR2 5NDD P2Y12 receptor 4NTJ
TM3 119 M 3.42x42 PAR2 5NDD GnRH1 receptor 7BR3
TM3 120 L 3.43x43 PAR2 5NDD PAR2 5NDD
TM3 121 S 3.44x44 PAR2 5NDD DP2 receptor 6D27
TM3 122 T 3.45x45 PAR2 5NDD C5a1 receptor 5O9H
TM3 123 V 3.46x46 PAR2 5NDD NK1 receptor 6HLP
TM3 124 S 3.47x47 PAR2 5NDD PAR2 5NDD
TM3 125 T 3.48x48 PAR2 5NDD - -
TM3 126 E 3.49x49 PAR2 5NDD TP receptor 6IIV
TM3 127 R 3.50x50 PAR2 5NDD PAR2 5NDD
TM3 128 C 3.51x51 PAR2 5NDD CysLT1 receptor 6RZ4
TM3 129 L 3.52x52 PAR2 5NDD LPA6 receptor 5XSZ
TM3 130 S 3.53x53 PAR2 5NDD CB1 receptor 5TGZ
TM3 131 V 3.54x54 PAR2 5NDD P2Y1 receptor 4XNW
TM3 132 L 3.55x55 PAR2 5NDD FPR2/ALX 6LW5
TM3 133 W 3.56x56 PAR2 5NDD - -
ICL2 134 P 34.50x50 - - - -
ICL2 135 I 34.51x51 C5a1 receptor 5O9H C5a1 receptor 6C1R
ICL2 136 W 34.52x52 C5a1 receptor 5O9H C5a1 receptor 5O9H
ICL2 137 Y 34.53x53 C5a1 receptor 5O9H MC4 receptor 6W25
ICL2 138 R 34.54x54 C5a1 receptor 5O9H LPA6 receptor 5XSZ
ICL2 139 C 34.55x55 C5a1 receptor 5O9H - -
ICL2 140 R 34.56x56 C5a1 receptor 5O9H P2Y1 receptor 4XNW
ICL2 141 R 34.57x57 - - - -
TM4 142 P 4.38x38 PAR2 5NDD - -
TM4 143 R 4.39x39 PAR2 5NDD PAF receptor 5ZKQ
TM4 144 H 4.40x40 PAR2 5NDD - -
TM4 145 L 4.41x41 PAR2 5NDD C5a1 receptor 5O9H
TM4 146 S 4.42x42 PAR2 5NDD FFA1 receptor 5TZY
TM4 147 A 4.43x43 PAR2 5NDD apelin receptor 5VBL
TM4 148 V 4.44x44 PAR2 5NDD AT1 receptor 4ZUD
TM4 149 V 4.45x45 PAR2 5NDD CysLT1 receptor 6RZ4
TM4 150 C 4.46x46 PAR2 5NDD CysLT1 receptor 6RZ4
TM4 151 V 4.47x47 PAR2 5NDD CysLT1 receptor 6RZ4
TM4 152 L 4.48x48 PAR2 5NDD P2Y1 receptor 4XNW
TM4 153 L 4.49x49 PAR2 5NDD DP2 receptor 6D27
TM4 154 W 4.50x50 PAR2 5NDD PAR2 5NDD
TM4 155 A 4.51x51 PAR2 5NDD PAR1 3VW7
TM4 156 L 4.52x52 PAR2 5NDD PAR2 5NDD
TM4 157 S 4.53x53 PAR2 5NDD 5-HT2B receptor 4IB4
TM4 158 L 4.54x54 PAR2 5NDD PAR2 5NDD
TM4 159 L 4.55x55 PAR2 5NDD PAR2 5NDD
TM4 160 L 4.56x56 PAR2 5NDD P2Y12 receptor 4NTJ
TM4 161 S 4.57x57 P2Y1 receptor 4XNW CysLT1 receptor 6RZ4
TM4 162 I 4.58x58 P2Y1 receptor 4XNW MC4 receptor 6W25
TM4 163 L 4.59x59 P2Y1 receptor 4XNW MC4 receptor 6W25
TM4 164 E 4.60x60 PAR2 5NDD - -
TM4 165 G 4.61x61 PAR2 5NDD LPA6 receptor 5XSZ
TM4 166 K 4.62x62 PAR2 5NDD - -
TM4 167 F 4.63x63 PAR2 5NDD GPR52 6LI1
TM4 168 C 4.64x64 C5a1 receptor 5O9H - -
ECL2 169 G - - - -
ECL2 170 F - - - -
ECL2 171 L - - - -
ECL2 172 F - - - -
ECL2 173 S - - - -
ECL2 174 D - - - -
ECL2 175 G - - - -
ECL2 176 D - - - -
TM5 177 S 5.31x31 DP2 receptor 6D27 apelin receptor 5VBL
TM5 178 G 5.32x32 PAR2 5NDD P2Y12 receptor 4NTJ
TM5 179 W 5.33x33 PAR2 5NDD apelin receptor 5VBL
TM5 180 C 5.34x34 PAR2 5NDD - -
TM5 181 Q 5.35x35 PAR2 5NDD - -
TM5 182 T 5.36x36 PAR2 5NDD - -
TM5 183 F 5.37x37 PAR2 5NDD PAR2 5NDD
TM5 184 D 5.38x38 PAR2 5NDD 5-HT2B receptor 4IB4
TM5 185 F 5.39x39 PAR2 5NDD PAR1 3VW7
TM5 186 I 5.40x40 PAR2 5NDD MC4 receptor 6W25
TM5 187 T 5.41x41 PAR2 5NDD GPR52 6LI1
TM5 188 A 5.42x42 PAR2 5NDD CCR7 6QZH
TM5 189 A 5.43x43 PAR2 5NDD CysLT2 receptor 6RZ6
TM5 190 W 5.44x44 PAR2 5NDD - -
TM5 191 L 5.45x45 PAR2 5NDD succinate receptor 6RNK
TM5 192 I 5.46x46 CB1 receptor 5TGZ P2Y12 receptor 4NTJ
TM5 193 F 5.47x47 CB1 receptor 5TGZ PAR2 5NDD
TM5 194 L 5.48x48 PAR2 5NDD PAR2 5NDD
TM5 195 F 5.49x49 PAR2 5NDD PAR2 5NDD
TM5 196 M 5.50x50 PAR2 5NDD MC4 receptor 6W25
TM5 197 V 5.51x51 PAR2 5NDD TP receptor 6IIV
TM5 198 L 5.52x52 PAR2 5NDD P2Y12 receptor 4NTJ
TM5 199 C 5.53x53 PAR2 5NDD ghrelin receptor 6KO5
TM5 200 G 5.54x54 PAR2 5NDD - -
TM5 201 S 5.55x55 PAR2 5NDD CysLT2 receptor 6RZ6
TM5 202 S 5.56x56 PAR2 5NDD PAR2 5NDD
TM5 203 L 5.57x57 PAR2 5NDD MC4 receptor 6W25
TM5 204 A 5.58x58 PAR2 5NDD - -
TM5 205 L 5.59x59 PAR2 5NDD CysLT2 receptor 6RZ6
TM5 206 L 5.60x60 PAR2 5NDD PAR2 5NDD
TM5 207 V 5.61x61 PAR2 5NDD LPA6 receptor 5XSZ
TM5 208 R 5.62x62 PAR2 5NDD AT2 receptor 6JOD
TM5 209 I 5.63x63 PAR2 5NDD NK1 receptor 6HLP
TM5 210 L 5.64x64 PAR2 5NDD A1 receptor 5UEN
TM5 211 C 5.65x65 PAR2 5NDD - -
TM5 212 G 5.66x66 C5a1 receptor 5O9H - -
TM5 213 S 5.67x67 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM5 214 R 5.68x68 C5a1 receptor 5O9H succinate receptor 6IBB
ICL3 215 G - - - -
ICL3 216 L - - - -
ICL3 217 P - - - -
TM6 218 L 6.30x30 PAR2 5NDD P2Y1 receptor 4XNW
TM6 219 T 6.31x31 PAR2 5NDD C5a1 receptor 6C1R
TM6 220 R 6.32x32 PAR2 5NDD P2Y1 receptor 4XNW
TM6 221 L 6.33x33 PAR2 5NDD apelin receptor 5VBL
TM6 222 Y 6.34x34 PAR2 5NDD - -
TM6 223 L 6.35x35 PAR2 5NDD CysLT2 receptor 6RZ6
TM6 224 T 6.36x36 PAR2 5NDD CysLT2 receptor 6RZ6
TM6 225 I 6.37x37 PAR2 5NDD LPA6 receptor 5XSZ
TM6 226 L 6.38x38 PAR2 5NDD μ receptor 5C1M
TM6 227 L 6.39x39 PAR2 5NDD succinate receptor 6RNK
TM6 228 T 6.40x40 PAR2 5NDD PAR2 5NDD
TM6 229 V 6.41x41 PAR2 5NDD PAR2 5NDD
TM6 230 L 6.42x42 PAR2 5NDD P2Y1 receptor 4XNW
TM6 231 V 6.43x43 PAR2 5NDD MC4 receptor 6W25
TM6 232 F 6.44x44 PAR2 5NDD LPA6 receptor 5XSZ
TM6 233 L 6.45x45 PAR2 5NDD 5-HT2B receptor 4IB4
TM6 234 L 6.46x46 C5a1 receptor 5O9H PAR2 5NDD
TM6 235 C 6.47x47 C5a1 receptor 5O9H PAR2 5NDD
TM6 236 G 6.48x48 PAR2 5NDD - -
TM6 237 L 6.49x49 PAR2 5NDD CysLT2 receptor 6RZ6
TM6 238 P 6.50x50 PAR2 5NDD PAR2 5NDD
TM6 239 F 6.51x51 PAR2 5NDD P2Y1 receptor 4XNW
TM6 240 G 6.52x52 PAR2 5NDD - -
TM6 241 I 6.53x53 PAR2 5NDD CysLT1 receptor 6RZ4
TM6 242 Q 6.54x54 PAR2 5NDD CysLT1 receptor 6RZ4
TM6 243 W 6.55x55 PAR2 5NDD - -
TM6 244 F 6.56x56 PAR2 5NDD AT1 receptor 4ZUD
TM6 245 L 6.57x57 PAR2 5NDD GPR52 6LI1
TM6 246 I 6.58x58 PAR2 5NDD H1 receptor 3RZE
TM6 247 L 6.59x59 PAR2 5NDD CysLT1 receptor 6RZ4
TM6 248 W 6.60x60 PAR2 5NDD Y1 receptor 5ZBH
TM6 249 I 6.61x61 PAR2 5NDD AT1 receptor 4ZUD
ECL3 250 W - - - -
TM7 251 K 7.25x24 C5a1 receptor 5O9H - -
TM7 252 D 7.26x25 C5a1 receptor 5O9H CysLT1 receptor 6RZ4
TM7 253 S 7.27x26 C5a1 receptor 5O9H CysLT1 receptor 6RZ4
TM7 254 D 7.28x27 C5a1 receptor 5O9H apelin receptor 5VBL
TM7 255 V 7.29x28 C5a1 receptor 5O9H - -
TM7 256 L 7.30x29 C5a1 receptor 5O9H C5a1 receptor 5O9H
TM7 257 F 7.31x30 PAR2 5NDD - -
TM7 258 C 7.32x31 PAR2 5NDD EP3 receptor 6M9T
TM7 259 H 7.33x32 PAR2 5NDD H1 receptor 3RZE
TM7 260 I 7.34x33 PAR2 5NDD LPA6 receptor 5XSZ
TM7 261 H 7.35x34 PAR2 5NDD PAF receptor 5ZKQ
TM7 262 P 7.36x35 PAR2 5NDD LPA6 receptor 5XSZ
TM7 263 V 7.37x36 PAR2 5NDD PAR2 5NDD
TM7 264 S 7.38x37 PAR2 5NDD ghrelin receptor 6KO5
TM7 265 V 7.39x38 PAR2 5NDD PAR1 3VW7
TM7 266 V 7.40x39 PAR2 5NDD CCR6 6WWZ
TM7 267 L 7.41x40 PAR2 5NDD PAR2 5NDD
TM7 268 S 7.42x41 PAR2 5NDD PAR2 5NDD
TM7 269 S 7.43x42 PAR2 5NDD P2Y1 receptor 4XNW
TM7 270 L 7.44x43 PAR2 5NDD PAR2 5NDD
TM7 271 N 7.45x45 PAR2 5NDD PAR2 5NDD
TM7 272 S 7.46x46 PAR2 5NDD PAR2 5NDD
TM7 273 S 7.47x47 PAR2 5NDD κ receptor 6B73
TM7 274 A 7.48x48 PAR2 5NDD DP2 receptor 6D27
TM7 275 N 7.49x49 PAR2 5NDD P2Y1 receptor 4XNW
TM7 276 P 7.50x50 PAR2 5NDD PAR2 5NDD
TM7 277 I 7.51x51 PAR2 5NDD P2Y1 receptor 4XNW
TM7 278 I 7.52x52 PAR2 5NDD PAR1 3VW7
TM7 279 Y 7.53x53 PAR2 5NDD PAR2 5NDD
TM7 280 F 7.54x54 PAR2 5NDD P2Y1 receptor 4XNW
TM7 281 F 7.55x55 PAR2 5NDD PAR2 5NDD
TM7 282 V 7.56x56 PAR2 5NDD PAR2 5NDD
H8 283 G 8.47x47 PAR2 5NDD AT1 receptor 6OS2
H8 284 S 8.48x48 PAR2 5NDD GPR52 6LI1
H8 285 F 8.49x49 PAR2 5NDD - -
H8 286 R 8.50x50 PAR2 5NDD - -
H8 287 K 8.51x51 PAR2 5NDD CysLT2 receptor 6RZ6
H8 288 Q 8.52x52 PAR2 5NDD apelin receptor 5VBL
H8 289 W 8.53x53 PAR2 5NDD - -
H8 290 R 8.54x54 PAR2 5NDD - -
H8 291 L 8.55x55 PAR2 5NDD AT1 receptor 6OS2
H8 292 Q 8.56x56 PAR2 5NDD AT1 receptor 6OS2
C-term 293 Q - - - -
C-term 294 P - - - -
C-term 295 I - - - -
C-term 296 L - - - -
C-term 297 K - - - -