Y4 receptor homology model
PROTEIN CLASS
Class A (Rhodopsin)
RECEPTOR
SPECIES
Homo sapiens
STATE
Intermediate
VERSION
2021-02-08
MODEL
TEMPLATES
5NDD (PAR2)
5ZBH (Y1 receptor)
5ZBQ (Y1 receptor)
5TZY (FFA1 receptor)
3SN6 (β2-adrenoceptor)
7DDZ (Y2 receptor)
None
5ZBH (Y1 receptor)
5ZBQ (Y1 receptor)
5TZY (FFA1 receptor)
3SN6 (β2-adrenoceptor)
7DDZ (Y2 receptor)
None
| Main template (%) | Additional templates (%) | No template - freely modelled (%) | |
|---|---|---|---|
| Backbone | 75.9 | 16.7 | 7.4 |
| Side-chains | 19.6 | 61.7 | 18.6 |
Number of backbone templates: 6
Number of rotamer templates: 45
| Segment | Seq.num. | AA | GPCRdb# | Backbone | PDB | Rotamer | PDB |
|---|---|---|---|---|---|---|---|
| N-term | 32 | E | PAR2 | 5NDD | PAR2 | 5NDD | |
| N-term | 33 | H | PAR2 | 5NDD | PAR2 | 5NDD | |
| N-term | 34 | C | PAR2 | 5NDD | PAR2 | 5NDD | |
| N-term | 35 | Q | PAR2 | 5NDD | PAR2 | 5NDD | |
| N-term | 36 | D | PAR2 | 5NDD | PAR2 | 5NDD | |
| TM1 | 37 | S | 1.28x28 | PAR2 | 5NDD | 5-HT1B receptor | 4IAQ |
| TM1 | 38 | V | 1.29x29 | PAR2 | 5NDD | - | - |
| TM1 | 39 | D | 1.30x30 | PAR2 | 5NDD | - | - |
| TM1 | 40 | V | 1.31x31 | PAR2 | 5NDD | Y2 receptor | 7DDZ |
| TM1 | 41 | M | 1.32x32 | PAR2 | 5NDD | M4 receptor | 6KP6 |
| TM1 | 42 | V | 1.33x33 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 43 | F | 1.34x34 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 44 | I | 1.35x35 | PAR2 | 5NDD | κ receptor | 6B73 |
| TM1 | 45 | V | 1.36x36 | PAR2 | 5NDD | NOP receptor | 5DHG |
| TM1 | 46 | T | 1.37x37 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM1 | 47 | S | 1.38x38 | PAR2 | 5NDD | D3 receptor | 3PBL |
| TM1 | 48 | Y | 1.39x39 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 49 | S | 1.40x40 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM1 | 50 | I | 1.41x41 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 51 | E | 1.42x42 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM1 | 52 | T | 1.43x43 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM1 | 53 | V | 1.44x44 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 54 | V | 1.45x45 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 55 | G | 1.46x46 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM1 | 56 | V | 1.47x47 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM1 | 57 | L | 1.48x48 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM1 | 58 | G | 1.49x49 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM1 | 59 | N | 1.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 60 | L | 1.51x51 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM1 | 61 | C | 1.52x52 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM1 | 62 | L | 1.53x53 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM1 | 63 | M | 1.54x54 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM1 | 64 | C | 1.55x55 | PAR2 | 5NDD | CB1 receptor | 5TGZ |
| TM1 | 65 | V | 1.56x56 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 66 | T | 1.57x57 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM1 | 67 | V | 1.58x58 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM1 | 68 | R | 1.59x59 | PAR2 | 5NDD | OX1 receptor | 6TO7 |
| TM1 | 69 | Q | 1.60x60 | PAR2 | 5NDD | CXCR4 | 3ODU |
| ICL1 | 70 | K | 12.48x48 | - | - | - | - |
| ICL1 | 71 | E | 12.49x49 | Y1 receptor | 5ZBH | Y1 receptor | 5ZBH |
| ICL1 | 72 | K | 12.50x50 | Y1 receptor | 5ZBH | - | - |
| ICL1 | 73 | A | 12.51x51 | - | - | - | - |
| TM2 | 74 | N | 2.37x37 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM2 | 75 | V | 2.38x38 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM2 | 76 | T | 2.39x39 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM2 | 77 | N | 2.40x40 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM2 | 78 | L | 2.41x41 | PAR2 | 5NDD | OX2 receptor | 6TPN |
| TM2 | 79 | L | 2.42x42 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM2 | 80 | I | 2.43x43 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM2 | 81 | A | 2.44x44 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 82 | N | 2.45x45 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 83 | L | 2.46x46 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 84 | A | 2.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 85 | F | 2.48x48 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM2 | 86 | S | 2.49x49 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM2 | 87 | D | 2.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 88 | F | 2.51x51 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM2 | 89 | L | 2.52x52 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 90 | M | 2.53x53 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM2 | 91 | C | 2.54x54 | PAR2 | 5NDD | C5a1 receptor | 5O9H |
| TM2 | 92 | L | 2.55x55 | Y1 receptor | 5ZBH | P2Y1 receptor | 4XNW |
| TM2 | 93 | L | 2.56x551 | Y1 receptor | 5ZBH | Y2 receptor | 7DDZ |
| TM2 | 94 | C | 2.57x56 | Y1 receptor | 5ZBH | Y1 receptor | 5ZBH |
| TM2 | 95 | Q | 2.58x57 | PAR2 | 5NDD | - | - |
| TM2 | 96 | P | 2.59x58 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 97 | L | 2.60x59 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 98 | T | 2.61x60 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM2 | 99 | A | 2.62x61 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM2 | 100 | V | 2.63x62 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM2 | 101 | Y | 2.64x63 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 102 | T | 2.65x64 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM2 | 103 | I | 2.66x65 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 104 | M | 2.67x66 | PAR2 | 5NDD | Y1 receptor | 5ZBQ |
| TM2 | 105 | D | 2.68x67 | Y1 receptor | 5ZBQ | Y1 receptor | 5ZBQ |
| ECL1 | 106 | Y | 23.49x49 | - | - | - | - |
| ECL1 | 107 | W | 23.50x50 | Y1 receptor | 5ZBQ | Y1 receptor | 5ZBQ |
| ECL1 | 108 | I | 23.51x51 | Y1 receptor | 5ZBQ | PAR2 | 5NDD |
| ECL1 | 109 | F | 23.52x52 | - | - | - | - |
| TM3 | 110 | G | 3.21x21 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 111 | E | 3.22x22 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 112 | T | 3.23x23 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM3 | 113 | L | 3.24x24 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 114 | C | 3.25x25 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 115 | K | 3.26x26 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM3 | 116 | M | 3.27x27 | PAR2 | 5NDD | A1 receptor | 5UEN |
| TM3 | 117 | S | 3.28x28 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM3 | 118 | A | 3.29x29 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM3 | 119 | F | 3.30x30 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM3 | 120 | I | 3.31x31 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM3 | 121 | Q | 3.32x32 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM3 | 122 | C | 3.33x33 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM3 | 123 | M | 3.34x34 | PAR2 | 5NDD | CCR7 | 6QZH |
| TM3 | 124 | S | 3.35x35 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM3 | 125 | V | 3.36x36 | PAR2 | 5NDD | Y2 receptor | 7DDZ |
| TM3 | 126 | T | 3.37x37 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM3 | 127 | V | 3.38x38 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM3 | 128 | S | 3.39x39 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 129 | I | 3.40x40 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 130 | L | 3.41x41 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 131 | S | 3.42x42 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM3 | 132 | L | 3.43x43 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 133 | V | 3.44x44 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM3 | 134 | L | 3.45x45 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM3 | 135 | V | 3.46x46 | PAR2 | 5NDD | NK1 receptor | 6HLP |
| TM3 | 136 | A | 3.47x47 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM3 | 137 | L | 3.48x48 | PAR2 | 5NDD | Y2 receptor | 7DDZ |
| TM3 | 138 | E | 3.49x49 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM3 | 139 | R | 3.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 140 | H | 3.51x51 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM3 | 141 | Q | 3.52x52 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM3 | 142 | L | 3.53x53 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM3 | 143 | I | 3.54x54 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 144 | I | 3.55x55 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM3 | 145 | N | 3.56x56 | PAR2 | 5NDD | PAR2 | 5NDD |
| ICL2 | 146 | P | - | - | - | - | |
| ICL2 | 147 | T | Y1 receptor | 5ZBH | - | - | |
| ICL2 | 148 | G | Y1 receptor | 5ZBH | Y1 receptor | 5ZBH | |
| ICL2 | 149 | W | Y1 receptor | 5ZBH | Y1 receptor | 5ZBH | |
| ICL2 | 150 | K | Y1 receptor | 5ZBH | - | - | |
| ICL2 | 151 | P | - | - | - | - | |
| TM4 | 152 | S | 4.38x38 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM4 | 153 | I | 4.39x39 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM4 | 154 | S | 4.40x40 | PAR2 | 5NDD | NOP receptor | 5DHG |
| TM4 | 155 | Q | 4.41x41 | PAR2 | 5NDD | AT2 receptor | 6JOD |
| TM4 | 156 | A | 4.42x42 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 157 | Y | 4.43x43 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM4 | 158 | L | 4.44x44 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM4 | 159 | G | 4.45x45 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM4 | 160 | I | 4.46x46 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM4 | 161 | V | 4.47x47 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM4 | 162 | L | 4.48x48 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM4 | 163 | I | 4.49x49 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 164 | W | 4.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 165 | V | 4.51x51 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM4 | 166 | I | 4.52x52 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM4 | 167 | A | 4.53x53 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM4 | 168 | C | 4.54x54 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM4 | 169 | V | 4.55x55 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM4 | 170 | L | 4.56x56 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM4 | 171 | S | 4.57x57 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM4 | 172 | L | 4.58x59 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM4 | 173 | P | 4.59x60 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 174 | F | 4.60x61 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM4 | 175 | L | 4.61x62 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM4 | 176 | A | 4.62x63 | PAR2 | 5NDD | OX1 receptor | 6TO7 |
| TM4 | 177 | N | 4.63x64 | Y1 receptor | 5ZBQ | - | - |
| TM4 | 178 | S | 4.64x65 | Y1 receptor | 5ZBQ | NK1 receptor | 6HLP |
| ECL2 | 179 | I | - | - | - | - | |
| ECL2 | 180 | L | FFA1 receptor | 5TZY | - | - | |
| ECL2 | 181 | E | FFA1 receptor | 5TZY | - | - | |
| ECL2 | 182 | N | FFA1 receptor | 5TZY | - | - | |
| ECL2 | 183 | V | FFA1 receptor | 5TZY | - | - | |
| ECL2 | 184 | F | FFA1 receptor | 5TZY | - | - | |
| ECL2 | 185 | H | FFA1 receptor | 5TZY | - | - | |
| ECL2 | 186 | K | FFA1 receptor | 5TZY | - | - | |
| ECL2 | 187 | N | FFA1 receptor | 5TZY | FFA1 receptor | 5TZY | |
| ECL2 | 188 | H | FFA1 receptor | 5TZY | - | - | |
| ECL2 | 189 | S | FFA1 receptor | 5TZY | FFA1 receptor | 5TZY | |
| ECL2 | 190 | K | FFA1 receptor | 5TZY | - | - | |
| ECL2 | 191 | A | FFA1 receptor | 5TZY | - | - | |
| ECL2 | 192 | L | FFA1 receptor | 5TZY | - | - | |
| ECL2 | 193 | E | FFA1 receptor | 5TZY | - | - | |
| ECL2 | 194 | F | FFA1 receptor | 5TZY | - | - | |
| ECL2 | 195 | L | FFA1 receptor | 5TZY | - | - | |
| ECL2 | 196 | A | - | - | - | - | |
| ECL2 | 197 | D | FFA1 receptor | 5TZY | - | - | |
| ECL2 | 198 | K | FFA1 receptor | 5TZY | - | - | |
| ECL2 | 199 | V | FFA1 receptor | 5TZY | - | - | |
| ECL2 | 200 | V | - | - | - | - | |
| ECL2 | 201 | C | 45.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| ECL2 | 202 | T | 45.51x51 | PAR2 | 5NDD | FPR2/ALX | 6OMM |
| ECL2 | 203 | E | 45.52x52 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| ECL2 | 204 | S | - | - | - | - | |
| ECL2 | 205 | W | Y1 receptor | 5ZBQ | - | - | |
| ECL2 | 206 | P | - | - | - | - | |
| TM5 | 207 | L | 5.31x32 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 208 | A | 5.32x33 | PAR2 | 5NDD | AT2 receptor | 6JOD |
| TM5 | 209 | H | 5.33x34 | PAR2 | 5NDD | - | - |
| TM5 | 210 | H | 5.34x35 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM5 | 211 | R | 5.35x36 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM5 | 212 | T | 5.36x37 | PAR2 | 5NDD | Y2 receptor | 7DDZ |
| TM5 | 213 | I | 5.37x38 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM5 | 214 | Y | 5.38x39 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 215 | T | 5.39x40 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM5 | 216 | T | 5.40x41 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM5 | 217 | F | 5.41x42 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM5 | 218 | L | 5.42x43 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 219 | L | 5.43x44 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM5 | 220 | L | 5.44x45 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM5 | 221 | F | 5.45x46 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM5 | 222 | Q | 5.46x461 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM5 | 223 | Y | 5.47x47 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM5 | 224 | C | 5.48x48 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM5 | 225 | L | 5.49x49 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM5 | 226 | P | 5.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 227 | L | 5.51x51 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM5 | 228 | G | 5.52x52 | PAR2 | 5NDD | TP receptor | 6IIV |
| TM5 | 229 | F | 5.53x53 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM5 | 230 | I | 5.54x54 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM5 | 231 | L | 5.55x55 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM5 | 232 | V | 5.56x56 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM5 | 233 | C | 5.57x57 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM5 | 234 | Y | 5.58x58 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 235 | A | 5.59x59 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM5 | 236 | R | 5.60x60 | PAR2 | 5NDD | Y2 receptor | 7DDZ |
| TM5 | 237 | I | 5.61x61 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM5 | 238 | Y | 5.62x62 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM5 | 239 | R | 5.63x63 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 240 | R | 5.64x64 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM5 | 241 | L | 5.65x65 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 242 | Q | 5.66x66 | β2-adrenoceptor | 3SN6 | 5-HT2B receptor | 4IB4 |
| TM5 | 243 | R | 5.67x67 | β2-adrenoceptor | 3SN6 | β2-adrenoceptor | 3SN6 |
| TM5 | 244 | Q | 5.68x68 | β2-adrenoceptor | 3SN6 | β2-adrenoceptor | 3SN6 |
| TM5 | 245 | G | 5.69x69 | β2-adrenoceptor | 3SN6 | FPR2/ALX | 6OMM |
| TM5 | 246 | R | 5.70x70 | β2-adrenoceptor | 3SN6 | M1 receptor | 6OIJ |
| TM5 | 247 | V | 5.71x71 | β2-adrenoceptor | 3SN6 | - | - |
| TM5 | 248 | F | 5.72x72 | β2-adrenoceptor | 3SN6 | - | - |
| ICL3 | 249 | H | - | - | - | - | |
| ICL3 | 250 | K | - | - | - | - | |
| ICL3 | 251 | G | - | - | - | - | |
| ICL3 | 252 | T | - | - | - | - | |
| ICL3 | 253 | Y | - | - | - | - | |
| TM6 | 254 | S | 6.24x24 | Y2 receptor | 7DDZ | - | - |
| TM6 | 255 | L | 6.25x25 | Y2 receptor | 7DDZ | D2 receptor | 6VMS |
| TM6 | 256 | R | 6.26x26 | Y2 receptor | 7DDZ | ghrelin receptor | 6KO5 |
| TM6 | 257 | A | 6.27x27 | PAR2 | 5NDD | 5-HT1B receptor | 4IAQ |
| TM6 | 258 | G | 6.28x28 | PAR2 | 5NDD | A1 receptor | 6D9H |
| TM6 | 259 | H | 6.29x29 | PAR2 | 5NDD | US28 | 5WB1 |
| TM6 | 260 | M | 6.30x30 | PAR2 | 5NDD | LPA1 receptor | 4Z35 |
| TM6 | 261 | K | 6.31x31 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM6 | 262 | Q | 6.32x32 | PAR2 | 5NDD | ghrelin receptor | 6KO5 |
| TM6 | 263 | V | 6.33x33 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM6 | 264 | N | 6.34x34 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM6 | 265 | V | 6.35x35 | PAR2 | 5NDD | MT1 receptor | 6ME2 |
| TM6 | 266 | V | 6.36x36 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM6 | 267 | L | 6.37x37 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 268 | V | 6.38x38 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM6 | 269 | V | 6.39x39 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 270 | M | 6.40x40 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM6 | 271 | V | 6.41x41 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 272 | V | 6.42x42 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM6 | 273 | A | 6.43x43 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 274 | F | 6.44x44 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM6 | 275 | A | 6.45x45 | PAR2 | 5NDD | TP receptor | 6IIV |
| TM6 | 276 | V | 6.46x46 | Y1 receptor | 5ZBH | Y1 receptor | 5ZBH |
| TM6 | 277 | L | 6.47x47 | Y1 receptor | 5ZBH | succinate receptor | 6RNK |
| TM6 | 278 | W | 6.48x48 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM6 | 279 | L | 6.49x49 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM6 | 280 | P | 6.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 281 | L | 6.51x51 | PAR2 | 5NDD | TP receptor | 6IIV |
| TM6 | 282 | H | 6.52x52 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM6 | 283 | V | 6.53x53 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM6 | 284 | F | 6.54x54 | PAR2 | 5NDD | TP receptor | 6IIV |
| TM6 | 285 | N | 6.55x55 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM6 | 286 | S | 6.56x56 | PAR2 | 5NDD | CXCR4 | 3ODU |
| TM6 | 287 | L | 6.57x57 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM6 | 288 | E | 6.58x58 | PAR2 | 5NDD | GPR52 | 6LI0 |
| TM6 | 289 | D | 6.59x59 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM6 | 290 | W | 6.60x60 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM6 | 291 | H | 6.61x61 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| ECL3 | 292 | H | - | - | - | - | |
| ECL3 | 293 | E | Y1 receptor | 5ZBH | - | - | |
| ECL3 | 294 | A | Y1 receptor | 5ZBH | - | - | |
| ECL3 | 295 | I | Y1 receptor | 5ZBH | Y1 receptor | 5ZBH | |
| ECL3 | 296 | P | - | - | - | - | |
| TM7 | 297 | I | 7.28x27 | Y1 receptor | 5ZBH | - | - |
| TM7 | 298 | C | 7.29x28 | Y1 receptor | 5ZBH | Y1 receptor | 5ZBH |
| TM7 | 299 | H | 7.30x29 | Y1 receptor | 5ZBH | CXCR2 | 6LFL |
| TM7 | 300 | G | 7.31x30 | PAR2 | 5NDD | - | - |
| TM7 | 301 | N | 7.32x31 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM7 | 302 | L | 7.33x32 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM7 | 303 | I | 7.34x33 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM7 | 304 | F | 7.35x34 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM7 | 305 | L | 7.36x35 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM7 | 306 | V | 7.37x36 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 307 | C | 7.38x37 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM7 | 308 | H | 7.39x38 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM7 | 309 | L | 7.40x39 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM7 | 310 | L | 7.41x40 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 311 | A | 7.42x41 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM7 | 312 | M | 7.43x42 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM7 | 313 | A | 7.44x43 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM7 | 314 | S | 7.45x45 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM7 | 315 | T | 7.46x46 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM7 | 316 | C | 7.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 317 | V | 7.48x48 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM7 | 318 | N | 7.49x49 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM7 | 319 | P | 7.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 320 | F | 7.51x51 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 321 | I | 7.52x52 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| TM7 | 322 | Y | 7.53x53 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 323 | G | 7.54x54 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM7 | 324 | F | 7.55x55 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 325 | L | 7.56x56 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| H8 | 326 | N | 8.47x47 | PAR2 | 5NDD | Rhodopsin | 1GZM |
| H8 | 327 | T | 8.48x48 | PAR2 | 5NDD | US28 | 5WB1 |
| H8 | 328 | N | 8.49x49 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| H8 | 329 | F | 8.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| H8 | 330 | K | 8.51x51 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| H8 | 331 | K | 8.52x52 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| H8 | 332 | E | 8.53x53 | PAR2 | 5NDD | OX2 receptor | 5WS3 |
| H8 | 333 | I | 8.54x54 | PAR2 | 5NDD | - | - |
| H8 | 334 | K | 8.55x55 | PAR2 | 5NDD | PAR2 | 5NDD |
| H8 | 335 | A | 8.56x56 | PAR2 | 5NDD | OX2 receptor | 5WS3 |
| H8 | 336 | L | 8.57x57 | PAR2 | 5NDD | GPR52 | 6LI1 |
| H8 | 337 | V | 8.58x58 | PAR2 | 5NDD | - | - |
| C-term | 338 | L | - | - | - | - | |
| C-term | 339 | T | - | - | - | - | |
| C-term | 340 | C | - | - | - | - | |
| C-term | 341 | Q | - | - | - | - | |
| C-term | 342 | Q | - | - | - | - |