NTS2 receptor homology model
PROTEIN CLASS
Class A (Rhodopsin)
RECEPTOR
SPECIES
Homo sapiens
STATE
Intermediate
VERSION
2021-09-08
MODEL
TEMPLATES
4XES (NTS1 receptor)
5T04 (NTS1 receptor)
6LI1 (GPR52)
7JVQ (D1 receptor)
6OSA (NTS1 receptor)
None
5T04 (NTS1 receptor)
6LI1 (GPR52)
7JVQ (D1 receptor)
6OSA (NTS1 receptor)
None
| Main template (%) | Additional templates (%) | No template - freely modelled (%) | |
|---|---|---|---|
| Backbone | 69.3 | 17.2 | 13.5 |
| Side-chains | 14.7 | 65.6 | 19.6 |
Number of backbone templates: 5
Number of rotamer templates: 54
| Segment | Seq.num. | AA | GPCRdb# | Backbone | PDB | Rotamer | PDB |
|---|---|---|---|---|---|---|---|
| N-term | 24 | G | - | NTS1 receptor | 4XES | NTS1 receptor | 4XES |
| N-term | 25 | V | - | NTS1 receptor | 4XES | NTS1 receptor | 4XES |
| N-term | 26 | D | - | NTS1 receptor | 4XES | NTS1 receptor | 4XES |
| N-term | 27 | T | - | NTS1 receptor | 4XES | NTS1 receptor | 4XES |
| N-term | 28 | R | - | NTS1 receptor | 4XES | NTS1 receptor | 4XES |
| TM1 | 29 | L | 1.29x29 | NTS1 receptor | 4XES | δ receptor | 4N6H |
| TM1 | 30 | W | 1.30x30 | NTS1 receptor | 4XES | M5 receptor | 6OL9 |
| TM1 | 31 | A | 1.31x31 | NTS1 receptor | 4XES | CCR9 | 5LWE |
| TM1 | 32 | K | 1.32x32 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM1 | 33 | V | 1.33x33 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM1 | 34 | L | 1.34x34 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM1 | 35 | F | 1.35x35 | GPR52 | 6LI1 | CysLT2 receptor | 6RZ6 |
| TM1 | 36 | T | 1.36x36 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM1 | 37 | A | 1.37x37 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM1 | 38 | L | 1.38x38 | GPR52 | 6LI1 | μ receptor | 5C1M |
| TM1 | 39 | Y | 1.39x39 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM1 | 40 | A | 1.40x40 | GPR52 | 6LI1 | 5-HT2A receptor | 6A94 |
| TM1 | 41 | L | 1.41x41 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM1 | 42 | I | 1.42x42 | GPR52 | 6LI1 | β1-adrenoceptor | 7BVQ |
| TM1 | 43 | W | 1.43x43 | GPR52 | 6LI1 | - | - |
| TM1 | 44 | A | 1.44x44 | GPR52 | 6LI1 | δ receptor | 4N6H |
| TM1 | 45 | L | 1.45x45 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM1 | 46 | G | 1.46x46 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM1 | 47 | A | 1.47x47 | GPR52 | 6LI1 | CCR9 | 5LWE |
| TM1 | 48 | A | 1.48x48 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM1 | 49 | G | 1.49x49 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM1 | 50 | N | 1.50x50 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM1 | 51 | A | 1.51x51 | GPR52 | 6LI1 | 5-HT1B receptor | 4IAQ |
| TM1 | 52 | L | 1.52x52 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM1 | 53 | S | 1.53x53 | GPR52 | 6LI1 | CysLT2 receptor | 6RZ6 |
| TM1 | 54 | A | 1.54x54 | GPR52 | 6LI1 | NTS1 receptor | 6UP7 |
| TM1 | 55 | H | 1.55x55 | GPR52 | 6LI1 | Y2 receptor | 7DDZ |
| TM1 | 56 | V | 1.56x56 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM1 | 57 | V | 1.57x57 | GPR52 | 6LI1 | ghrelin receptor | 6KO5 |
| TM1 | 58 | L | 1.58x58 | GPR52 | 6LI1 | CXCR2 | 6LFL |
| TM1 | 59 | K | 1.59x59 | GPR52 | 6LI1 | OX2 receptor | 5WQC |
| TM1 | 60 | A | 1.60x60 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| ICL1 | 61 | R | - | - | - | - | - |
| ICL1 | 62 | A | - | D1 receptor | 7JVQ | - | - |
| ICL1 | 63 | G | - | D1 receptor | 7JVQ | - | - |
| ICL1 | 64 | R | - | D1 receptor | 7JVQ | D1 receptor | 7JVQ |
| ICL1 | 65 | A | - | - | - | - | - |
| TM2 | 66 | G | 2.37x37 | GPR52 | 6LI1 | - | - |
| TM2 | 67 | R | 2.38x38 | GPR52 | 6LI1 | OT receptor | 6TPK |
| TM2 | 68 | L | 2.39x39 | GPR52 | 6LI1 | Rhodopsin | 1U19 |
| TM2 | 69 | R | 2.40x40 | GPR52 | 6LI1 | - | - |
| TM2 | 70 | H | 2.41x41 | GPR52 | 6LI1 | CB1 receptor | 5TGZ |
| TM2 | 71 | H | 2.42x42 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM2 | 72 | V | 2.43x43 | GPR52 | 6LI1 | D3 receptor | 7CMV |
| TM2 | 73 | L | 2.44x44 | GPR52 | 6LI1 | CXCR2 | 6LFL |
| TM2 | 74 | S | 2.45x45 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM2 | 75 | L | 2.46x46 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM2 | 76 | A | 2.47x47 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM2 | 77 | L | 2.48x48 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM2 | 78 | A | 2.49x49 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM2 | 79 | G | 2.50x50 | GPR52 | 6LI1 | δ receptor | 6PT2 |
| TM2 | 80 | L | 2.51x51 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM2 | 81 | L | 2.52x52 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM2 | 82 | L | 2.53x53 | GPR52 | 6LI1 | 5-HT2A receptor | 6A94 |
| TM2 | 83 | L | 2.54x54 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM2 | 84 | L | 2.55x55 | NTS1 receptor | 4XES | NTS1 receptor | 4XES |
| TM2 | 85 | V | 2.56x551 | NTS1 receptor | 4XES | H1 receptor | 3RZE |
| TM2 | 86 | G | 2.57x56 | NTS1 receptor | 4XES | Rhodopsin | 1U19 |
| TM2 | 87 | V | 2.58x57 | GPR52 | 6LI1 | β1-adrenoceptor | 7BVQ |
| TM2 | 88 | P | 2.59x58 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM2 | 89 | V | 2.60x59 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM2 | 90 | E | 2.61x60 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM2 | 91 | L | 2.62x61 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM2 | 92 | Y | 2.63x62 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM2 | 93 | S | 2.64x63 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM2 | 94 | F | 2.65x64 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM2 | 95 | V | 2.66x65 | GPR52 | 6LI1 | D2 receptor | 7JVR |
| TM2 | 96 | W | 2.67x66 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM2 | 97 | F | 2.68x67 | NTS1 receptor | 4XES | - | - |
| ECL1 | 98 | H | - | - | - | - | - |
| ECL1 | 99 | Y | - | NTS1 receptor | 4XES | - | - |
| ECL1 | 100 | P | 23.49x49 | NTS1 receptor | 4XES | NTS1 receptor | 4XES |
| ECL1 | 101 | W | 23.50x50 | NTS1 receptor | 4XES | NTS1 receptor | 4XES |
| ECL1 | 102 | V | 23.51x51 | NTS1 receptor | 4XES | CCR7 | 6QZH |
| ECL1 | 103 | F | 23.52x52 | - | - | - | - |
| TM3 | 104 | G | 3.21x21 | GPR52 | 6LI1 | Rhodopsin | 1F88 |
| TM3 | 105 | D | 3.22x22 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM3 | 106 | L | 3.23x23 | GPR52 | 6LI1 | GPR52 | 6LI0 |
| TM3 | 107 | G | 3.24x24 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM3 | 108 | C | 3.25x25 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM3 | 109 | R | 3.26x26 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM3 | 110 | G | 3.27x27 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM3 | 111 | Y | 3.28x28 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM3 | 112 | Y | 3.29x29 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM3 | 113 | F | 3.30x30 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM3 | 114 | V | 3.31x31 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM3 | 115 | H | 3.32x32 | GPR52 | 6LI1 | FFA1 receptor | 5TZY |
| TM3 | 116 | E | 3.33x33 | GPR52 | 6LI1 | ghrelin receptor | 6KO5 |
| TM3 | 117 | L | 3.34x34 | GPR52 | 6LI1 | 5-HT2A receptor | 6A94 |
| TM3 | 118 | C | 3.35x35 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM3 | 119 | A | 3.36x36 | GPR52 | 6LI1 | A2A receptor | 5IU4 |
| TM3 | 120 | Y | 3.37x37 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM3 | 121 | A | 3.38x38 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM3 | 122 | T | 3.39x39 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM3 | 123 | V | 3.40x40 | GPR52 | 6LI1 | ghrelin receptor | 6KO5 |
| TM3 | 124 | L | 3.41x41 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM3 | 125 | S | 3.42x42 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM3 | 126 | V | 3.43x43 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM3 | 127 | A | 3.44x44 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM3 | 128 | G | 3.45x45 | GPR52 | 6LI1 | apelin receptor | 5VBL |
| TM3 | 129 | L | 3.46x46 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM3 | 130 | S | 3.47x47 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM3 | 131 | A | 3.48x48 | GPR52 | 6LI1 | P2Y1 receptor | 4XNW |
| TM3 | 132 | E | 3.49x49 | GPR52 | 6LI1 | NTS1 receptor | 4BUO |
| TM3 | 133 | R | 3.50x50 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM3 | 134 | C | 3.51x51 | GPR52 | 6LI1 | CysLT1 receptor | 6RZ4 |
| TM3 | 135 | L | 3.52x52 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM3 | 136 | A | 3.53x53 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM3 | 137 | V | 3.54x54 | GPR52 | 6LI1 | μ receptor | 5C1M |
| TM3 | 138 | C | 3.55x55 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM3 | 139 | Q | 3.56x56 | GPR52 | 6LI1 | CCR9 | 5LWE |
| ICL2 | 140 | P | 34.50x50 | - | - | - | - |
| ICL2 | 141 | L | 34.51x51 | NTS1 receptor | 4XES | GPR52 | 6LI0 |
| ICL2 | 142 | R | 34.52x52 | NTS1 receptor | 4XES | ghrelin receptor | 6KO5 |
| ICL2 | 143 | A | 34.53x53 | NTS1 receptor | 4XES | NTS1 receptor | 4XES |
| ICL2 | 144 | R | 34.54x54 | NTS1 receptor | 4XES | LPA6 receptor | 5XSZ |
| ICL2 | 145 | S | 34.55x55 | NTS1 receptor | 4XES | β1-adrenoceptor | 7BVQ |
| ICL2 | 146 | L | 34.56x56 | NTS1 receptor | 4XES | NTS1 receptor | 4XES |
| ICL2 | 147 | L | 34.57x57 | - | - | - | - |
| TM4 | 148 | T | 4.38x38 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM4 | 149 | P | 4.39x39 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM4 | 150 | R | 4.40x40 | GPR52 | 6LI1 | OX1 receptor | 6TO7 |
| TM4 | 151 | R | 4.41x41 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM4 | 152 | T | 4.42x42 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM4 | 153 | R | 4.43x43 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM4 | 154 | W | 4.44x44 | GPR52 | 6LI1 | BLT1 receptor | 5X33 |
| TM4 | 155 | L | 4.45x45 | GPR52 | 6LI1 | β1-adrenoceptor | 7BVQ |
| TM4 | 156 | V | 4.46x46 | GPR52 | 6LI1 | β1-adrenoceptor | 7BVQ |
| TM4 | 157 | A | 4.47x47 | GPR52 | 6LI1 | 5-HT2C receptor | 6BQH |
| TM4 | 158 | L | 4.48x48 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM4 | 159 | S | 4.49x49 | GPR52 | 6LI1 | - | - |
| TM4 | 160 | W | 4.50x50 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM4 | 161 | A | 4.51x51 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM4 | 162 | A | 4.52x52 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM4 | 163 | S | 4.53x53 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM4 | 164 | L | 4.54x54 | GPR52 | 6LI1 | OX1 receptor | 6TO7 |
| TM4 | 165 | G | 4.55x55 | GPR52 | 6LI1 | δ receptor | 4N6H |
| TM4 | 166 | L | 4.56x56 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM4 | 167 | A | 4.57x57 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM4 | 168 | L | 4.58x59 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM4 | 169 | P | 4.59x60 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM4 | 170 | M | 4.60x61 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM4 | 171 | A | 4.61x62 | GPR52 | 6LI1 | OX2 receptor | 5WQC |
| TM4 | 172 | V | 4.62x63 | GPR52 | 6LI1 | ghrelin receptor | 6KO5 |
| TM4 | 173 | I | 4.63x64 | NTS1 receptor | 4XES | 5-HT2C receptor | 6BQH |
| TM4 | 174 | M | 4.64x65 | NTS1 receptor | 4XES | NTS1 receptor | 4XES |
| ECL2 | 175 | G | - | - | - | - | - |
| ECL2 | 176 | Q | - | - | - | - | - |
| ECL2 | 177 | K | - | - | - | - | - |
| ECL2 | 178 | H | - | - | - | - | - |
| ECL2 | 179 | E | - | - | - | - | - |
| ECL2 | 180 | L | - | - | - | - | - |
| ECL2 | 181 | E | - | - | - | - | - |
| ECL2 | 182 | T | - | - | - | - | - |
| ECL2 | 183 | A | - | - | - | - | - |
| ECL2 | 184 | D | - | - | - | - | - |
| ECL2 | 185 | G | - | - | - | - | - |
| ECL2 | 186 | E | - | - | - | - | - |
| ECL2 | 187 | P | - | - | - | - | - |
| ECL2 | 188 | E | - | - | - | - | - |
| ECL2 | 189 | P | - | - | - | - | - |
| ECL2 | 190 | A | - | - | - | - | - |
| ECL2 | 191 | S | - | - | - | - | - |
| ECL2 | 192 | R | - | - | - | - | - |
| ECL2 | 193 | V | - | - | - | - | - |
| ECL2 | 194 | C | 45.50x50 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| ECL2 | 195 | T | 45.51x51 | GPR52 | 6LI1 | FPR2/ALX | 6OMM |
| ECL2 | 196 | V | 45.52x52 | GPR52 | 6LI1 | - | - |
| ECL2 | 197 | L | - | - | - | - | - |
| ECL2 | 198 | V | - | NTS1 receptor | 4XES | NTS1 receptor | 4XES |
| ECL2 | 199 | S | - | - | - | - | - |
| TM5 | 200 | R | 5.32x33 | NTS1 receptor | 4XES | - | - |
| TM5 | 201 | T | 5.33x34 | NTS1 receptor | 4XES | FPR2/ALX | 6OMM |
| TM5 | 202 | A | 5.34x35 | NTS1 receptor | 4XES | OX1 receptor | 6TO7 |
| TM5 | 203 | L | 5.35x36 | NTS1 receptor | 4XES | NTS1 receptor | 4BUO |
| TM5 | 204 | Q | 5.36x37 | GPR52 | 6LI1 | - | - |
| TM5 | 205 | V | 5.37x38 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM5 | 206 | F | 5.38x39 | GPR52 | 6LI1 | D2 receptor | 7JVR |
| TM5 | 207 | I | 5.39x40 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM5 | 208 | Q | 5.40x41 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM5 | 209 | V | 5.41x42 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM5 | 210 | N | 5.42x43 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM5 | 211 | V | 5.43x44 | GPR52 | 6LI1 | MT1 receptor | 6ME2 |
| TM5 | 212 | L | 5.44x45 | GPR52 | 6LI1 | OX2 receptor | 5WQC |
| TM5 | 213 | V | 5.45x46 | GPR52 | 6LI1 | OX2 receptor | 5WQC |
| TM5 | 214 | S | 5.46x461 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM5 | 215 | F | 5.47x47 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM5 | 216 | V | 5.48x48 | GPR52 | 6LI1 | κ receptor | 4DJH |
| TM5 | 217 | L | 5.49x49 | GPR52 | 6LI1 | ghrelin receptor | 6KO5 |
| TM5 | 218 | P | 5.50x50 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM5 | 219 | L | 5.51x51 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM5 | 220 | A | 5.52x52 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM5 | 221 | L | 5.53x53 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM5 | 222 | T | 5.54x54 | GPR52 | 6LI1 | D2 receptor | 7JVR |
| TM5 | 223 | A | 5.55x55 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM5 | 224 | F | 5.56x56 | GPR52 | 6LI1 | CXCR2 | 6LFL |
| TM5 | 225 | L | 5.57x57 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM5 | 226 | N | 5.58x58 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM5 | 227 | G | 5.59x59 | GPR52 | 6LI1 | μ receptor | 5C1M |
| TM5 | 228 | V | 5.60x60 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM5 | 229 | T | 5.61x61 | GPR52 | 6LI1 | 5-HT2A receptor | 6A94 |
| TM5 | 230 | V | 5.62x62 | GPR52 | 6LI1 | P2Y1 receptor | 4XNW |
| TM5 | 231 | S | 5.63x63 | GPR52 | 6LI1 | Y2 receptor | 7DDZ |
| TM5 | 232 | H | 5.64x64 | GPR52 | 6LI1 | AT2 receptor | 5UNG |
| TM5 | 233 | L | 5.65x65 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM5 | 234 | L | 5.66x66 | GPR52 | 6LI1 | ETB receptor | 5X93 |
| TM5 | 235 | A | 5.67x67 | GPR52 | 6LI1 | NK1 receptor | 6HLP |
| TM5 | 236 | L | 5.68x68 | GPR52 | 6LI1 | 5-HT1F receptor | 7EXD |
| TM5 | 237 | C | 5.69x69 | NTS1 receptor | 6OSA | EP3 receptor | 6AK3 |
| TM5 | 238 | S | 5.70x70 | NTS1 receptor | 6OSA | EP2 receptor | 7CX2 |
| TM5 | 239 | Q | 5.71x71 | NTS1 receptor | 6OSA | NTS1 receptor | 6OSA |
| TM5 | 240 | V | 5.72x72 | NTS1 receptor | 6OSA | D2 receptor | 7JVR |
| TM5 | 241 | P | 5.73x73 | NTS1 receptor | 6OSA | - | - |
| TM5 | 242 | S | 5.74x74 | NTS1 receptor | 6OSA | A2A receptor | 4UHR |
| ICL3 | 243 | T | - | - | - | - | - |
| ICL3 | 244 | S | - | - | - | - | - |
| ICL3 | 245 | T | - | - | - | - | - |
| ICL3 | 246 | P | - | - | - | - | - |
| ICL3 | 247 | G | - | - | - | - | - |
| ICL3 | 281 | V | - | - | - | - | - |
| ICL3 | 282 | R | - | - | - | - | - |
| ICL3 | 283 | H | - | - | - | - | - |
| ICL3 | 284 | K | - | - | - | - | - |
| ICL3 | 285 | D | - | - | - | - | - |
| TM6 | 286 | V | 6.24x24 | NTS1 receptor | 5T04 | OX1 receptor | 6TO7 |
| TM6 | 287 | R | 6.25x25 | NTS1 receptor | 5T04 | LPA1 receptor | 4Z35 |
| TM6 | 288 | R | 6.26x26 | NTS1 receptor | 5T04 | NTS1 receptor | 5T04 |
| TM6 | 289 | I | 6.27x27 | NTS1 receptor | 5T04 | OX2 receptor | 5WQC |
| TM6 | 290 | R | 6.28x28 | NTS1 receptor | 5T04 | OX2 receptor | 5WQC |
| TM6 | 291 | S | 6.29x29 | NTS1 receptor | 5T04 | δ receptor | 4N6H |
| TM6 | 292 | L | 6.30x30 | NTS1 receptor | 5T04 | NTS1 receptor | 5T04 |
| TM6 | 293 | Q | 6.31x31 | GPR52 | 6LI1 | 5-HT2A receptor | 6A94 |
| TM6 | 294 | R | 6.32x32 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM6 | 295 | S | 6.33x33 | GPR52 | 6LI1 | - | - |
| TM6 | 296 | V | 6.34x34 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM6 | 297 | Q | 6.35x35 | GPR52 | 6LI1 | D2 receptor | 7JVR |
| TM6 | 298 | V | 6.36x36 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM6 | 299 | L | 6.37x37 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM6 | 300 | R | 6.38x38 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM6 | 301 | A | 6.39x39 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM6 | 302 | I | 6.40x40 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM6 | 303 | V | 6.41x41 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM6 | 304 | V | 6.42x42 | GPR52 | 6LI1 | δ receptor | 6PT2 |
| TM6 | 305 | M | 6.43x43 | GPR52 | 6LI1 | - | - |
| TM6 | 306 | Y | 6.44x44 | GPR52 | 6LI1 | CCR2 | 5T1A |
| TM6 | 307 | V | 6.45x45 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM6 | 308 | I | 6.46x46 | GPR52 | 6LI1 | OX2 receptor | 5WQC |
| TM6 | 309 | C | 6.47x47 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM6 | 310 | W | 6.48x48 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM6 | 311 | L | 6.49x49 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM6 | 312 | P | 6.50x50 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM6 | 313 | Y | 6.51x51 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM6 | 314 | H | 6.52x52 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM6 | 315 | A | 6.53x53 | GPR52 | 6LI1 | Y2 receptor | 7DDZ |
| TM6 | 316 | R | 6.54x54 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM6 | 317 | R | 6.55x55 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM6 | 318 | L | 6.56x56 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM6 | 319 | M | 6.57x57 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM6 | 320 | Y | 6.58x58 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM6 | 321 | C | 6.59x59 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM6 | 322 | Y | 6.60x60 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM6 | 323 | V | 6.61x61 | NTS1 receptor | 4XES | δ receptor | 4N6H |
| ECL3 | 324 | P | - | - | - | - | - |
| ECL3 | 325 | D | - | NTS1 receptor | 4XES | NTS1 receptor | 4XES |
| ECL3 | 326 | D | - | NTS1 receptor | 4XES | - | - |
| ECL3 | 327 | A | - | NTS1 receptor | 4XES | - | - |
| ECL3 | 328 | W | - | - | - | - | - |
| TM7 | 329 | T | 7.24x23 | NTS1 receptor | 4XES | NTS1 receptor | 4XES |
| TM7 | 330 | D | 7.25x24 | NTS1 receptor | 4XES | - | - |
| TM7 | 331 | P | 7.26x25 | NTS1 receptor | 4XES | C5a1 receptor | 6C1Q |
| TM7 | 332 | L | 7.27x26 | NTS1 receptor | 4XES | NTS1 receptor | 4XES |
| TM7 | 333 | Y | 7.28x27 | NTS1 receptor | 4XES | NTS1 receptor | 6OSA |
| TM7 | 334 | N | 7.29x28 | NTS1 receptor | 4XES | CXCR2 | 6LFL |
| TM7 | 335 | F | 7.30x29 | NTS1 receptor | 4XES | NTS1 receptor | 4XES |
| TM7 | 336 | Y | 7.31x30 | GPR52 | 6LI1 | - | - |
| TM7 | 337 | H | 7.32x31 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM7 | 338 | Y | 7.33x32 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM7 | 339 | F | 7.34x33 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM7 | 340 | Y | 7.35x34 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM7 | 341 | M | 7.36x35 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM7 | 342 | V | 7.37x36 | GPR52 | 6LI1 | NTS1 receptor | 6OSA |
| TM7 | 343 | T | 7.38x37 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM7 | 344 | N | 7.39x38 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM7 | 345 | T | 7.40x39 | GPR52 | 6LI1 | CCR2 | 5T1A |
| TM7 | 346 | L | 7.41x40 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM7 | 347 | F | 7.42x41 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM7 | 348 | Y | 7.43x42 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM7 | 349 | V | 7.44x43 | GPR52 | 6LI1 | NTS1 receptor | 4BUO |
| TM7 | 350 | S | 7.45x45 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM7 | 351 | S | 7.46x46 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM7 | 352 | A | 7.47x47 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM7 | 353 | V | 7.48x48 | GPR52 | 6LI1 | D2 receptor | 7JVR |
| TM7 | 354 | T | 7.49x49 | GPR52 | 6LI1 | - | - |
| TM7 | 355 | P | 7.50x50 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM7 | 356 | L | 7.51x51 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| TM7 | 357 | L | 7.52x52 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM7 | 358 | Y | 7.53x53 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| TM7 | 359 | N | 7.54x54 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| TM7 | 360 | A | 7.55x55 | GPR52 | 6LI1 | - | - |
| TM7 | 361 | V | 7.56x56 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| H8 | 362 | S | 8.47x47 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| H8 | 363 | S | 8.48x48 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| H8 | 364 | S | 8.49x49 | GPR52 | 6LI1 | V2 receptor | 7KH0 |
| H8 | 365 | F | 8.50x50 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| H8 | 366 | R | 8.51x51 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| H8 | 367 | K | 8.52x52 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| H8 | 368 | L | 8.53x53 | GPR52 | 6LI1 | EP2 receptor | 7CX2 |
| H8 | 369 | F | 8.54x54 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| H8 | 370 | L | 8.55x55 | GPR52 | 6LI1 | NTS1 receptor | 4XES |
| H8 | 371 | E | 8.56x56 | GPR52 | 6LI1 | MC4 receptor | 6W25 |
| H8 | 372 | A | 8.57x57 | GPR52 | 6LI1 | OX2 receptor | 5WQC |
| H8 | 373 | V | 8.58x58 | GPR52 | 6LI1 | 5-HT1D receptor | 7E32 |
| H8 | 374 | S | 8.59x59 | GPR52 | 6LI1 | OX2 receptor | 5WQC |
| H8 | 375 | S | 8.60x60 | GPR52 | 6LI1 | MT1 receptor | 6ME2 |
| H8 | 376 | L | 8.61x61 | GPR52 | 6LI1 | NTS1 receptor | 6OSA |
| H8 | 377 | C | 8.62x62 | GPR52 | 6LI1 | GPR52 | 6LI1 |
| C-term | 378 | G | - | - | - | - | - |
| C-term | 379 | E | - | - | - | - | - |
| C-term | 380 | H | - | - | - | - | - |
| C-term | 381 | H | - | - | - | - | - |
| C-term | 382 | P | - | - | - | - | - |