Olfactory receptor 1A1 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

Olfactory receptor 1A1

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-01-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

MC4 receptor (sequence similarity: 35%) PDB: 6W25
Align

TEMPLATES

5UEN (A1 receptor)
6W25 (MC4 receptor)
7DFP (D2 receptor)
4UHR (A2A receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 70.5 12.3 17.1
Side-chains 12.0 57.9 30.1

Number of backbone templates: 4
Number of rotamer templates: 50

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 18 T - - - -
N-term 19 G - - - -
N-term 20 Q - - - -
N-term 21 Q - - - -
N-term 22 E - - - -
TM1 23 Q 1.31x31 A1 receptor 5UEN P2Y1 receptor 4XNW
TM1 24 E 1.32x32 A1 receptor 5UEN OX2 receptor 5WS3
TM1 25 D 1.33x33 A1 receptor 5UEN AT2 receptor 5UNH
TM1 26 F 1.34x34 A1 receptor 5UEN CysLT2 receptor 6RZ6
TM1 27 F 1.35x35 MC4 receptor 6W25 - -
TM1 28 Y 1.36x36 MC4 receptor 6W25 - -
TM1 29 I 1.37x37 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM1 30 L 1.38x38 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM1 31 F 1.39x39 MC4 receptor 6W25 MC4 receptor 6W25
TM1 32 L 1.40x40 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM1 33 F 1.41x41 MC4 receptor 6W25 α2B-adrenoceptor 6K41
TM1 34 I 1.42x42 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM1 35 Y 1.43x43 MC4 receptor 6W25 - -
TM1 36 P 1.44x44 MC4 receptor 6W25 - -
TM1 37 I 1.45x45 MC4 receptor 6W25 MC4 receptor 6W25
TM1 38 T 1.46x46 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM1 39 L 1.47x47 MC4 receptor 6W25 MC4 receptor 6W25
TM1 40 I 1.48x48 MC4 receptor 6W25 LPA6 receptor 5XSZ
TM1 41 G 1.49x49 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM1 42 N 1.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM1 43 L 1.51x51 MC4 receptor 6W25 GPR52 6LI1
TM1 44 L 1.52x52 MC4 receptor 6W25 MC4 receptor 6W25
TM1 45 I 1.53x53 MC4 receptor 6W25 DP2 receptor 6D27
TM1 46 V 1.54x54 MC4 receptor 6W25 succinate receptor 6RNK
TM1 47 L 1.55x55 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM1 48 A 1.56x56 MC4 receptor 6W25 MC4 receptor 6W25
TM1 49 I 1.57x57 MC4 receptor 6W25 MC4 receptor 6W25
TM1 50 C 1.58x58 MC4 receptor 6W25 EP4 receptor 5YWY
TM1 51 S 1.59x59 MC4 receptor 6W25 D4 receptor 6IQL
TM1 52 D 1.60x60 MC4 receptor 6W25 - -
ICL1 53 V 12.48x48 - - - -
ICL1 54 R 12.49x49 A1 receptor 5UEN LPA1 receptor 4Z36
ICL1 55 L 12.50x50 A1 receptor 5UEN A1 receptor 5UEN
ICL1 56 H 12.51x51 - - - -
TM2 57 N 2.37x37 MC4 receptor 6W25 LPA6 receptor 5XSZ
TM2 58 P 2.38x38 MC4 receptor 6W25 MC4 receptor 6W25
TM2 59 M 2.39x39 MC4 receptor 6W25 MC4 receptor 6W25
TM2 60 Y 2.40x40 MC4 receptor 6W25 MC4 receptor 6W25
TM2 61 F 2.41x41 MC4 receptor 6W25 MC4 receptor 6W25
TM2 62 L 2.42x42 MC4 receptor 6W25 D2 receptor 6CM4
TM2 63 L 2.43x43 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM2 64 A 2.44x44 MC4 receptor 6W25 PAR2 5NDD
TM2 65 N 2.45x45 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM2 66 L 2.46x46 MC4 receptor 6W25 MC4 receptor 6W25
TM2 67 S 2.47x47 MC4 receptor 6W25 succinate receptor 6RNK
TM2 68 L 2.48x48 MC4 receptor 6W25 P2Y1 receptor 4XNW
TM2 69 V 2.49x49 MC4 receptor 6W25 - -
TM2 70 D 2.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM2 71 I 2.51x51 MC4 receptor 6W25 A2A receptor 4UHR
TM2 72 F 2.52x52 MC4 receptor 6W25 GPR52 6LI1
TM2 73 F 2.53x53 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM2 74 S 2.54x54 MC4 receptor 6W25 MC4 receptor 6W25
TM2 75 S 2.55x55 A1 receptor 5UEN CysLT2 receptor 6RZ6
TM2 76 V 2.56x551 A1 receptor 5UEN TP receptor 6IIV
TM2 77 T 2.57x56 A1 receptor 5UEN CysLT2 receptor 6RZ6
TM2 78 I 2.58x57 MC4 receptor 6W25 A1 receptor 5UEN
TM2 79 P 2.59x58 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM2 80 K 2.60x59 MC4 receptor 6W25 - -
TM2 81 M 2.61x60 MC4 receptor 6W25 - -
TM2 82 L 2.62x61 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM2 83 A 2.63x62 MC4 receptor 6W25 PAR2 5NDD
TM2 84 N 2.64x63 MC4 receptor 6W25 α2B-adrenoceptor 6K41
TM2 85 H 2.65x64 MC4 receptor 6W25 PAR2 5NDD
TM2 86 L 2.66x65 MC4 receptor 6W25 CysLT2 receptor 6RZ6
ECL1 87 L - - - -
ECL1 88 G - - - -
ECL1 89 S - - - -
ECL1 90 K - - - -
ECL1 91 S - - - -
ECL1 92 I - - - -
TM3 93 S 3.21x21 MC4 receptor 6W25 - -
TM3 94 F 3.22x22 MC4 receptor 6W25 A1 receptor 5UEN
TM3 95 G 3.23x23 MC4 receptor 6W25 - -
TM3 96 G 3.24x24 MC4 receptor 6W25 A2A receptor 4UHR
TM3 97 C 3.25x25 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM3 98 L 3.26x26 MC4 receptor 6W25 A1 receptor 5UEN
TM3 99 T 3.27x27 MC4 receptor 6W25 D4 receptor 6IQL
TM3 100 Q 3.28x28 MC4 receptor 6W25 P2Y1 receptor 4XNW
TM3 101 M 3.29x29 MC4 receptor 6W25 D4 receptor 6IQL
TM3 102 Y 3.30x30 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM3 103 F 3.31x31 MC4 receptor 6W25 PAR2 5NDD
TM3 104 M 3.32x32 MC4 receptor 6W25 TP receptor 6IIV
TM3 105 I 3.33x33 MC4 receptor 6W25 TP receptor 6IIV
TM3 106 A 3.34x34 MC4 receptor 6W25 MC4 receptor 6W25
TM3 107 L 3.35x35 MC4 receptor 6W25 GPR52 6LI1
TM3 108 G 3.36x36 MC4 receptor 6W25 TP receptor 6IIV
TM3 109 N 3.37x37 MC4 receptor 6W25 M2 receptor 5ZKC
TM3 110 T 3.38x38 MC4 receptor 6W25 succinate receptor 6RNK
TM3 111 D 3.39x39 MC4 receptor 6W25 - -
TM3 112 S 3.40x40 MC4 receptor 6W25 - -
TM3 113 Y 3.41x41 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM3 114 I 3.42x42 MC4 receptor 6W25 EP4 receptor 5YWY
TM3 115 L 3.43x43 MC4 receptor 6W25 MC4 receptor 6W25
TM3 116 A 3.44x44 MC4 receptor 6W25 GPR52 6LI1
TM3 117 A 3.45x45 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM3 118 M 3.46x46 MC4 receptor 6W25 CysLT1 receptor 6RZ4
TM3 119 A 3.47x47 MC4 receptor 6W25 MC4 receptor 6W25
TM3 120 Y 3.48x48 MC4 receptor 6W25 PAF receptor 5ZKQ
TM3 121 D 3.49x49 MC4 receptor 6W25 MC4 receptor 6W25
TM3 122 R 3.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM3 123 A 3.51x51 MC4 receptor 6W25 PAR2 5NDD
TM3 124 V 3.52x52 MC4 receptor 6W25 5-HT2A receptor 6A94
TM3 125 A 3.53x53 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM3 126 I 3.54x54 MC4 receptor 6W25 MC4 receptor 6W25
TM3 127 S 3.55x55 MC4 receptor 6W25 α2B-adrenoceptor 6K41
TM3 128 R 3.56x56 MC4 receptor 6W25 P2Y12 receptor 4NTJ
ICL2 129 P 34.50x50 - - - -
ICL2 130 L 34.51x51 A1 receptor 5UEN A1 receptor 5UEN
ICL2 131 H 34.52x52 A1 receptor 5UEN D3 receptor 3PBL
ICL2 132 Y 34.53x53 A1 receptor 5UEN A1 receptor 5UEN
ICL2 133 T 34.54x54 A1 receptor 5UEN - -
ICL2 134 T 34.55x55 A1 receptor 5UEN CXCR2 6LFO
ICL2 135 I 34.56x56 A1 receptor 5UEN MC4 receptor 6W25
ICL2 136 M 34.57x57 - - - -
TM4 137 S 4.38x38 MC4 receptor 6W25 5-HT2B receptor 5TVN
TM4 138 P 4.39x39 MC4 receptor 6W25 GPR52 6LI1
TM4 139 R 4.40x40 MC4 receptor 6W25 CysLT2 receptor 6RZ8
TM4 140 S 4.41x41 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM4 141 C 4.42x42 MC4 receptor 6W25 - -
TM4 142 I 4.43x43 MC4 receptor 6W25 P2Y1 receptor 4XNW
TM4 143 W 4.44x44 MC4 receptor 6W25 BLT1 receptor 5X33
TM4 144 L 4.45x45 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM4 145 I 4.46x46 MC4 receptor 6W25 MC4 receptor 6W25
TM4 146 A 4.47x47 MC4 receptor 6W25 LPA6 receptor 5XSZ
TM4 147 G 4.48x48 MC4 receptor 6W25 CysLT1 receptor 6RZ4
TM4 148 S 4.49x49 MC4 receptor 6W25 - -
TM4 149 W 4.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM4 150 V 4.51x51 MC4 receptor 6W25 LPA6 receptor 5XSZ
TM4 151 I 4.52x52 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM4 152 G 4.53x53 MC4 receptor 6W25 - -
TM4 153 N 4.54x54 MC4 receptor 6W25 - -
TM4 154 A 4.55x55 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM4 155 N 4.56x56 MC4 receptor 6W25 DP2 receptor 6D27
TM4 156 A 4.57x57 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM4 157 L 4.58x58 MC4 receptor 6W25 LPA6 receptor 5XSZ
TM4 158 P 4.59x59 MC4 receptor 6W25 LPA6 receptor 5XSZ
TM4 159 H 4.60x60 MC4 receptor 6W25 - -
TM4 160 T 4.61x61 MC4 receptor 6W25 CCR6 6WWZ
TM4 161 L 4.62x62 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM4 162 L 4.63x63 MC4 receptor 6W25 PAR1 3VW7
TM4 163 T 4.64x64 MC4 receptor 6W25 NTS1 receptor 4BUO
ECL2 164 A - - - -
ECL2 165 S - - - -
ECL2 166 L - - - -
ECL2 167 S - - - -
ECL2 168 F - - - -
ECL2 169 C - - - -
ECL2 170 G - - - -
ECL2 171 N - - - -
ECL2 172 Q - - - -
ECL2 173 E - - - -
ECL2 174 V - - - -
ECL2 175 A - - - -
ECL2 176 N - - - -
ECL2 177 F - - - -
ECL2 178 Y - - - -
ECL2 179 C - - - -
ECL2 180 D - - - -
ECL2 181 I - - - -
ECL2 182 T - - - -
ECL2 183 P - - - -
ECL2 184 L - - - -
ECL2 185 L - - - -
ECL2 186 K - - - -
ECL2 187 L - - - -
ECL2 188 S - - - -
ECL2 189 C 45.50x50 D2 receptor 7DFP D2 receptor 7DFP
ECL2 190 S 45.51x51 D2 receptor 7DFP D3 receptor 3PBL
ECL2 191 D 45.52x52 D2 receptor 7DFP PAR1 3VW7
ECL2 192 I - - - -
ECL2 193 H - - - -
TM5 194 F 5.35x36 MC4 receptor 6W25 5-HT2B receptor 5TUD
TM5 195 H 5.36x37 MC4 receptor 6W25 - -
TM5 196 V 5.37x38 MC4 receptor 6W25 CysLT1 receptor 6RZ5
TM5 197 K 5.38x39 MC4 receptor 6W25 ETB receptor 5X93
TM5 198 M 5.39x40 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM5 199 M 5.40x41 MC4 receptor 6W25 P2Y1 receptor 4XNW
TM5 200 Y 5.41x42 MC4 receptor 6W25 D2 receptor 6CM4
TM5 201 L 5.42x43 MC4 receptor 6W25 MC4 receptor 6W25
TM5 202 G 5.43x44 MC4 receptor 6W25 - -
TM5 203 V 5.44x45 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM5 204 G 5.45x46 A1 receptor 5UEN PAR2 5NDD
TM5 205 I 5.46x461 A1 receptor 5UEN NK1 receptor 6HLP
TM5 206 F 5.47x47 A1 receptor 5UEN A1 receptor 5UEN
TM5 207 S 5.48x48 MC4 receptor 6W25 CB1 receptor 5TGZ
TM5 208 V 5.49x49 MC4 receptor 6W25 PAR1 3VW7
TM5 209 P 5.50x50 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM5 210 L 5.51x51 MC4 receptor 6W25 MC4 receptor 6W25
TM5 211 L 5.52x52 MC4 receptor 6W25 P2Y12 receptor 4NTJ
TM5 212 C 5.53x53 MC4 receptor 6W25 ghrelin receptor 6KO5
TM5 213 I 5.54x54 MC4 receptor 6W25 P2Y1 receptor 4XNW
TM5 214 I 5.55x55 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM5 215 V 5.56x56 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM5 216 S 5.57x57 MC4 receptor 6W25 BLT1 receptor 5X33
TM5 217 Y 5.58x58 MC4 receptor 6W25 MC4 receptor 6W25
TM5 218 I 5.59x59 MC4 receptor 6W25 D2 receptor 6CM4
TM5 219 R 5.60x60 MC4 receptor 6W25 A2A receptor 4UHR
TM5 220 V 5.61x61 MC4 receptor 6W25 LPA6 receptor 5XSZ
TM5 221 F 5.62x62 MC4 receptor 6W25 MC4 receptor 6W25
TM5 222 S 5.63x63 MC4 receptor 6W25 S1P1 receptor 3V2Y
TM5 223 T 5.64x64 MC4 receptor 6W25 LPA6 receptor 5XSZ
TM5 224 V 5.65x65 A2A receptor 4UHR S1P1 receptor 3V2Y
TM5 225 F 5.66x66 A2A receptor 4UHR CXCR2 6LFL
TM5 226 Q 5.67x67 A2A receptor 4UHR MT1 receptor 6ME2
TM5 227 V 5.68x68 A2A receptor 4UHR CysLT2 receptor 6RZ6
TM5 228 P 5.69x69 A2A receptor 4UHR - -
TM5 229 S 5.70x70 A2A receptor 4UHR - -
TM5 230 T 5.71x71 A2A receptor 4UHR - -
TM5 231 K 5.72x72 A2A receptor 4UHR EP3 receptor 6AK3
ICL3 232 G - - - -
ICL3 233 V - - - -
TM6 234 L 6.23x23 A2A receptor 4UHR - -
TM6 235 K 6.24x24 A2A receptor 4UHR D2 receptor 6VMS
TM6 236 A 6.25x25 A2A receptor 4UHR α2B-adrenoceptor 6K42
TM6 237 F 6.26x26 A2A receptor 4UHR - -
TM6 238 S 6.27x27 A2A receptor 4UHR PAR2 5NDD
TM6 239 T 6.28x28 MC4 receptor 6W25 - -
TM6 240 C 6.29x29 MC4 receptor 6W25 - -
TM6 241 G 6.30x30 MC4 receptor 6W25 - -
TM6 242 S 6.31x31 MC4 receptor 6W25 FPR2/ALX 6OMM
TM6 243 H 6.32x32 MC4 receptor 6W25 A2A receptor 4UHR
TM6 244 L 6.33x33 MC4 receptor 6W25 S1P1 receptor 3V2Y
TM6 245 T 6.34x34 MC4 receptor 6W25 D2 receptor 6CM4
TM6 246 V 6.35x35 MC4 receptor 6W25 MT1 receptor 6ME2
TM6 247 V 6.36x36 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM6 248 S 6.37x37 MC4 receptor 6W25 - -
TM6 249 L 6.38x38 MC4 receptor 6W25 μ receptor 5C1M
TM6 250 Y 6.39x39 MC4 receptor 6W25 - -
TM6 251 Y 6.40x40 MC4 receptor 6W25 D2 receptor 6VMS
TM6 252 G 6.41x41 MC4 receptor 6W25 - -
TM6 253 T 6.42x42 MC4 receptor 6W25 CysLT1 receptor 6RZ4
TM6 254 V 6.43x43 MC4 receptor 6W25 MC4 receptor 6W25
TM6 255 M 6.44x44 MC4 receptor 6W25 PAR2 5NDD
TM6 256 G 6.45x45 MC4 receptor 6W25 GPBA receptor 7CFN
TM6 257 T 6.46x46 MC4 receptor 6W25 - -
TM6 258 Y 6.47x47 MC4 receptor 6W25 - -
TM6 259 F 6.48x48 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM6 260 R 6.49x49 MC4 receptor 6W25 - -
TM6 261 P 6.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM6 262 L 6.51x51 MC4 receptor 6W25 TP receptor 6IIV
TM6 263 T 6.52x52 MC4 receptor 6W25 Y1 receptor 5ZBH
TM6 264 N 6.53x53 MC4 receptor 6W25 - -
TM6 265 Y 6.54x54 MC4 receptor 6W25 GPR52 6LI1
ECL3 266 S - - - -
TM7 267 L 7.32x31 A1 receptor 5UEN A2A receptor 4UHR
TM7 268 K 7.33x32 A1 receptor 5UEN CysLT2 receptor 6RZ6
TM7 269 D 7.34x33 MC4 receptor 6W25 - -
TM7 270 A 7.35x34 MC4 receptor 6W25 S1P1 receptor 3V2Y
TM7 271 V 7.36x35 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM7 272 I 7.37x36 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM7 273 T 7.38x37 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM7 274 V 7.39x38 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM7 275 M 7.40x39 MC4 receptor 6W25 CB1 receptor 5TGZ
TM7 276 Y 7.41x40 MC4 receptor 6W25 - -
TM7 277 T 7.42x41 MC4 receptor 6W25 P2Y12 receptor 4NTJ
TM7 278 A 7.43x42 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM7 279 V 7.44x43 MC4 receptor 6W25 5-HT2B receptor 4IB4
TM7 280 T 7.45x45 MC4 receptor 6W25 - -
TM7 281 P 7.46x46 MC4 receptor 6W25 EP4 receptor 5YWY
TM7 282 M 7.47x47 MC4 receptor 6W25 NK1 receptor 6HLP
TM7 283 L 7.48x48 MC4 receptor 6W25 P2Y12 receptor 4NTJ
TM7 284 N 7.49x49 MC4 receptor 6W25 MC4 receptor 6W25
TM7 285 P 7.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM7 286 F 7.51x51 MC4 receptor 6W25 P2Y12 receptor 4NTJ
TM7 287 I 7.52x52 MC4 receptor 6W25 MC4 receptor 6W25
TM7 288 Y 7.53x53 MC4 receptor 6W25 MC4 receptor 6W25
TM7 289 S 7.54x54 MC4 receptor 6W25 LPA1 receptor 4Z35
TM7 290 L 7.55x55 MC4 receptor 6W25 MC4 receptor 6W25
TM7 291 R 7.56x56 MC4 receptor 6W25 MC4 receptor 6W25
H8 292 N 8.47x47 MC4 receptor 6W25 5-HT2B receptor 4IB4
H8 293 R 8.48x48 MC4 receptor 6W25 TP receptor 6IIV
H8 294 D 8.49x49 MC4 receptor 6W25 PAR2 5NDD
H8 295 M 8.50x50 MC4 receptor 6W25 S1P1 receptor 3V2Y
H8 296 K 8.51x51 MC4 receptor 6W25 CysLT2 receptor 6RZ6
H8 297 A 8.52x52 MC4 receptor 6W25 LPA1 receptor 4Z35
H8 298 A 8.53x53 MC4 receptor 6W25 5-HT2B receptor 4IB4
H8 299 L 8.54x54 MC4 receptor 6W25 CysLT2 receptor 6RZ6
H8 300 R 8.55x55 MC4 receptor 6W25 GPR52 6LI1
H8 301 K 8.56x56 MC4 receptor 6W25 A1 receptor 5UEN
H8 302 L 8.57x57 MC4 receptor 6W25 GPR52 6LI1
H8 303 F 8.58x58 MC4 receptor 6W25 NK1 receptor 6HLP
H8 304 N 8.59x59 MC4 receptor 6W25 A1 receptor 5UEN
C-term 305 K - - - -
C-term 306 R - - - -
C-term 307 I - - - -
C-term 308 S - - - -
C-term 309 S - - - -