P2RY8 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

P2RY8

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-11-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

PAR2 (sequence similarity: 39%) PDB: 5NDD
Align

TEMPLATES

5NDD (PAR2)
4XNW (P2Y1 receptor)
3VW7 (PAR1)
7BR3 (GnRH1 receptor)
6LFL (CXCR2)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 86.5 6.3 7.3
Side-chains 33.7 50.2 16.2

Number of backbone templates: 5
Number of rotamer templates: 44

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 14 L - PAR2 5NDD PAR2 5NDD
N-term 15 Q - PAR2 5NDD PAR2 5NDD
N-term 16 M - PAR2 5NDD PAR2 5NDD
N-term 17 L - PAR2 5NDD PAR2 5NDD
N-term 18 R - PAR2 5NDD PAR2 5NDD
TM1 19 N 1.28x28 PAR2 5NDD CB1 receptor 5U09
TM1 20 P 1.29x29 PAR2 5NDD Rhodopsin 1U19
TM1 21 A 1.30x30 PAR2 5NDD δ receptor 4N6H
TM1 22 I 1.31x31 PAR2 5NDD κ receptor 4DJH
TM1 23 A 1.32x32 PAR2 5NDD δ receptor 4N6H
TM1 24 V 1.33x33 PAR2 5NDD PAR2 5NDD
TM1 25 A 1.34x34 PAR2 5NDD δ receptor 4N6H
TM1 26 L 1.35x35 PAR2 5NDD PAR2 5NDD
TM1 27 P 1.36x36 PAR2 5NDD PAR2 5NDD
TM1 28 V 1.37x37 PAR2 5NDD MC4 receptor 6W25
TM1 29 V 1.38x38 PAR2 5NDD PAR2 5NDD
TM1 30 Y 1.39x39 PAR2 5NDD PAR2 5NDD
TM1 31 S 1.40x40 PAR2 5NDD LPA6 receptor 5XSZ
TM1 32 L 1.41x41 PAR2 5NDD P2Y1 receptor 4XNW
TM1 33 V 1.42x42 PAR2 5NDD PAR2 5NDD
TM1 34 A 1.43x43 PAR2 5NDD A1 receptor 5UEN
TM1 35 A 1.44x44 PAR2 5NDD FFA1 receptor 5TZY
TM1 36 V 1.45x45 PAR2 5NDD PAR2 5NDD
TM1 37 S 1.46x46 PAR2 5NDD PAR1 3VW7
TM1 38 I 1.47x47 PAR2 5NDD 5-HT2B receptor 5TVN
TM1 39 P 1.48x48 PAR2 5NDD PAR2 5NDD
TM1 40 G 1.49x49 PAR2 5NDD P2Y1 receptor 4XNW
TM1 41 N 1.50x50 PAR2 5NDD PAR2 5NDD
TM1 42 L 1.51x51 PAR2 5NDD TP receptor 6IIV
TM1 43 F 1.52x52 PAR2 5NDD CysLT1 receptor 6RZ4
TM1 44 S 1.53x53 PAR2 5NDD CysLT2 receptor 6RZ6
TM1 45 L 1.54x54 PAR2 5NDD PAR2 5NDD
TM1 46 W 1.55x55 PAR2 5NDD PAR2 5NDD
TM1 47 V 1.56x56 PAR2 5NDD PAR2 5NDD
TM1 48 L 1.57x57 PAR2 5NDD CysLT1 receptor 6RZ4
TM1 49 C 1.58x58 PAR2 5NDD AT2 receptor 5UNG
TM1 50 R 1.59x59 PAR2 5NDD δ receptor 4N6H
TM1 51 R 1.60x60 PAR2 5NDD PAR2 5NDD
ICL1 52 M - PAR2 5NDD - -
ICL1 53 G - PAR2 5NDD - -
ICL1 54 P - PAR2 5NDD - -
ICL1 55 R - PAR2 5NDD - -
TM2 56 S 2.37x37 PAR2 5NDD P2Y1 receptor 4XNW
TM2 57 P 2.38x38 PAR2 5NDD PAR2 5NDD
TM2 58 S 2.39x39 PAR2 5NDD FFA1 receptor 5TZY
TM2 59 V 2.40x40 PAR2 5NDD PAR2 5NDD
TM2 60 I 2.41x41 PAR2 5NDD PAR2 5NDD
TM2 61 F 2.42x42 PAR2 5NDD CysLT2 receptor 6RZ6
TM2 62 M 2.43x43 PAR2 5NDD PAR2 5NDD
TM2 63 I 2.44x44 PAR2 5NDD CysLT1 receptor 6RZ4
TM2 64 N 2.45x45 PAR2 5NDD PAR2 5NDD
TM2 65 L 2.46x46 PAR2 5NDD PAR2 5NDD
TM2 66 S 2.47x47 PAR2 5NDD succinate receptor 6RNK
TM2 67 V 2.48x48 PAR2 5NDD LPA6 receptor 5XSZ
TM2 68 T 2.49x49 PAR2 5NDD TP receptor 6IIV
TM2 69 D 2.50x50 PAR2 5NDD PAR2 5NDD
TM2 70 L 2.51x51 PAR2 5NDD PAR2 5NDD
TM2 71 M 2.52x52 PAR2 5NDD CCK1 receptor 7EZM
TM2 72 L 2.53x53 PAR2 5NDD FFA1 receptor 5TZY
TM2 73 A 2.54x54 PAR2 5NDD CXCR2 6LFL
TM2 74 S 2.55x55 PAR2 5NDD PAR1 3VW7
TM2 75 V 2.56x56 PAR2 5NDD PAR1 3VW7
TM2 76 L 2.57x57 PAR2 5NDD PAR1 3VW7
TM2 77 P 2.58x58 PAR2 5NDD PAR2 5NDD
TM2 78 F 2.59x59 PAR2 5NDD PAR1 3VW7
TM2 79 Q 2.60x60 PAR2 5NDD δ receptor 4N6H
TM2 80 I 2.61x61 PAR2 5NDD PAR2 5NDD
TM2 81 Y 2.62x62 PAR2 5NDD CCR7 6QZH
TM2 82 Y 2.63x63 PAR2 5NDD PAR2 5NDD
TM2 83 H 2.64x64 PAR2 5NDD PAR2 5NDD
TM2 84 C 2.65x65 PAR2 5NDD Rhodopsin 6I9K
TM2 85 N 2.66x66 PAR2 5NDD P2Y1 receptor 4XNW
ECL1 86 R - PAR2 5NDD - -
ECL1 87 H - PAR2 5NDD - -
ECL1 88 H 23.49x49 PAR2 5NDD Y1 receptor 5ZBH
ECL1 89 W 23.50x50 PAR2 5NDD PAR2 5NDD
ECL1 90 V 23.51x51 PAR2 5NDD CCR7 6QZH
ECL1 91 F 23.52x52 PAR2 5NDD PAR1 3VW7
TM3 92 G 3.21x21 PAR2 5NDD PAR2 5NDD
TM3 93 V 3.22x22 PAR2 5NDD MC4 receptor 6W25
TM3 94 L 3.23x23 PAR2 5NDD CysLT2 receptor 6RZ6
TM3 95 L 3.24x24 PAR2 5NDD PAR2 5NDD
TM3 96 C 3.25x25 PAR2 5NDD PAR2 5NDD
TM3 97 N 3.26x26 PAR2 5NDD PAR2 5NDD
TM3 98 V 3.27x27 PAR2 5NDD PAR2 5NDD
TM3 99 V 3.28x28 PAR2 5NDD PAR1 3VW7
TM3 100 T 3.29x29 PAR2 5NDD PAR1 3VW7
TM3 101 V 3.30x30 PAR2 5NDD P2Y12 receptor 4NTJ
TM3 102 A 3.31x31 PAR2 5NDD PAR1 3VW7
TM3 103 F 3.32x32 PAR2 5NDD PAR2 5NDD
TM3 104 Y 3.33x33 PAR2 5NDD PAR2 5NDD
TM3 105 A 3.34x34 PAR2 5NDD PAR2 5NDD
TM3 106 N 3.35x35 PAR2 5NDD PAR2 5NDD
TM3 107 M 3.36x36 PAR2 5NDD PAR2 5NDD
TM3 108 Y 3.37x37 PAR2 5NDD PAR2 5NDD
TM3 109 S 3.38x38 PAR2 5NDD CysLT2 receptor 6RZ6
TM3 110 S 3.39x39 PAR2 5NDD PAR2 5NDD
TM3 111 I 3.40x40 PAR2 5NDD PAR2 5NDD
TM3 112 L 3.41x41 PAR2 5NDD PAR2 5NDD
TM3 113 T 3.42x42 PAR2 5NDD δ receptor 4N6H
TM3 114 M 3.43x43 PAR2 5NDD PAR1 3VW7
TM3 115 T 3.44x44 PAR2 5NDD PAR2 5NDD
TM3 116 C 3.45x45 PAR2 5NDD PAR2 5NDD
TM3 117 I 3.46x46 PAR2 5NDD PAR1 3VW7
TM3 118 S 3.47x47 PAR2 5NDD PAR2 5NDD
TM3 119 V 3.48x48 PAR2 5NDD PAR2 5NDD
TM3 120 E 3.49x49 PAR2 5NDD TP receptor 6IIV
TM3 121 R 3.50x50 PAR2 5NDD PAR2 5NDD
TM3 122 F 3.51x51 PAR2 5NDD PAR1 3VW7
TM3 123 L 3.52x52 PAR2 5NDD PAR1 3VW7
TM3 124 G 3.53x53 PAR2 5NDD P2Y1 receptor 4XNW
TM3 125 V 3.54x54 PAR2 5NDD PAR1 3VW7
TM3 126 L 3.55x55 PAR2 5NDD FPR2/ALX 6OMM
TM3 127 Y 3.56x56 PAR2 5NDD PAR1 3VW7
ICL2 128 P 34.50x50 - - - -
ICL2 129 L 34.51x51 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
ICL2 130 S 34.52x52 P2Y1 receptor 4XNW GPR52 6LI1
ICL2 131 S 34.53x53 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
ICL2 132 K 34.54x54 P2Y1 receptor 4XNW ghrelin receptor 6KO5
ICL2 133 R 34.55x55 P2Y1 receptor 4XNW CCR6 6WWZ
ICL2 134 W 34.56x56 P2Y1 receptor 4XNW CCK1 receptor 7EZM
ICL2 135 R 34.57x57 - - - -
TM4 136 R 4.38x38 PAR2 5NDD CCR9 5LWE
TM4 137 R 4.39x39 PAR2 5NDD PAF receptor 5ZKQ
TM4 138 R 4.40x40 PAR2 5NDD CysLT2 receptor 6RZ8
TM4 139 Y 4.41x41 PAR2 5NDD FFA1 receptor 5TZY
TM4 140 A 4.42x42 PAR2 5NDD PAR2 5NDD
TM4 141 V 4.43x43 PAR2 5NDD CCR5 4MBS
TM4 142 A 4.44x44 PAR2 5NDD TP receptor 6IIV
TM4 143 A 4.45x45 PAR2 5NDD apelin receptor 5VBL
TM4 144 C 4.46x46 PAR2 5NDD PAR1 3VW7
TM4 145 A 4.47x47 PAR2 5NDD LPA6 receptor 5XSZ
TM4 146 G 4.48x48 PAR2 5NDD CysLT1 receptor 6RZ4
TM4 147 T 4.49x49 PAR2 5NDD CCR5 4MBS
TM4 148 W 4.50x50 PAR2 5NDD PAR2 5NDD
TM4 149 L 4.51x51 PAR2 5NDD PAR2 5NDD
TM4 150 L 4.52x52 PAR2 5NDD PAR2 5NDD
TM4 151 L 4.53x53 PAR2 5NDD - -
TM4 152 L 4.54x54 PAR2 5NDD PAR2 5NDD
TM4 153 T 4.55x55 PAR2 5NDD CCK1 receptor 7EZM
TM4 154 A 4.56x56 PAR2 5NDD P2Y1 receptor 4XNW
TM4 155 L 4.57x57 P2Y1 receptor 4XNW FFA1 receptor 5TZY
TM4 156 S 4.58x58 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM4 157 P 4.59x59 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
TM4 158 L 4.60x60 PAR2 5NDD BILF1 7JHJ
TM4 159 A 4.61x61 PAR2 5NDD AT1 receptor 4ZUD
TM4 160 R 4.62x62 PAR2 5NDD - -
ECL2 161 T - PAR2 5NDD - -
ECL2 162 D - PAR2 5NDD - -
ECL2 163 L - PAR2 5NDD - -
ECL2 164 T - PAR2 5NDD PAR2 5NDD
ECL2 165 Y - PAR2 5NDD - -
ECL2 166 P - PAR2 5NDD - -
ECL2 167 V - PAR2 5NDD - -
ECL2 168 H - PAR2 5NDD - -
ECL2 169 A - PAR2 5NDD PAR2 5NDD
ECL2 170 L - PAR2 5NDD PAR2 5NDD
ECL2 171 G - PAR2 5NDD - -
ECL2 172 I - PAR2 5NDD PAR2 5NDD
ECL2 173 I - PAR2 5NDD - -
ECL2 174 T - PAR2 5NDD PAR2 5NDD
ECL2 175 C 45.50x50 PAR2 5NDD PAR2 5NDD
ECL2 176 F 45.51x51 PAR2 5NDD LPA6 receptor 5XSZ
ECL2 177 D 45.52x52 PAR2 5NDD PAR2 5NDD
ECL2 178 V - - - - -
ECL2 179 L - - - - -
ECL2 180 K - - - - -
ECL2 181 W - - - - -
ECL2 182 T - - - - -
ECL2 183 M - - - - -
ECL2 184 L - - - - -
ECL2 185 P - - - - -
TM5 186 S 5.31x32 PAR2 5NDD δ receptor 4N6H
TM5 187 V 5.32x33 PAR2 5NDD PAR2 5NDD
TM5 188 A 5.33x34 PAR2 5NDD CysLT2 receptor 6RZ6
TM5 189 M 5.34x35 PAR2 5NDD CCK1 receptor 7EZM
TM5 190 W 5.35x36 PAR2 5NDD - -
TM5 191 A 5.36x37 PAR2 5NDD AT2 receptor 5UNG
TM5 192 V 5.37x38 PAR2 5NDD CysLT1 receptor 6RZ5
TM5 193 F 5.38x39 PAR2 5NDD PAR1 3VW7
TM5 194 L 5.39x40 PAR2 5NDD BLT1 receptor 7K15
TM5 195 F 5.40x41 PAR2 5NDD FFA1 receptor 5TZY
TM5 196 T 5.41x42 PAR2 5NDD AT1 receptor 4ZUD
TM5 197 I 5.42x43 PAR2 5NDD LPA6 receptor 5XSZ
TM5 198 F 5.43x44 PAR2 5NDD δ receptor 4N6H
TM5 199 I 5.44x45 PAR2 5NDD PAR2 5NDD
TM5 200 L 5.45x46 PAR2 5NDD FFA1 receptor 5TZY
TM5 201 L 5.46x461 PAR2 5NDD FFA1 receptor 5TZY
TM5 202 F 5.47x47 PAR2 5NDD PAR2 5NDD
TM5 203 L 5.48x48 PAR2 5NDD PAR2 5NDD
TM5 204 I 5.49x49 PAR2 5NDD LPA6 receptor 5XSZ
TM5 205 P 5.50x50 PAR2 5NDD PAR2 5NDD
TM5 206 F 5.51x51 PAR2 5NDD CysLT2 receptor 6RZ6
TM5 207 V 5.52x52 PAR2 5NDD P2Y1 receptor 4XNW
TM5 208 I 5.53x53 PAR2 5NDD PAR1 3VW7
TM5 209 T 5.54x54 PAR2 5NDD PAR2 5NDD
TM5 210 V 5.55x55 PAR2 5NDD LPA6 receptor 5XSZ
TM5 211 A 5.56x56 PAR2 5NDD BLT1 receptor 7K15
TM5 212 C 5.57x57 PAR2 5NDD PAR1 3VW7
TM5 213 Y 5.58x58 PAR2 5NDD PAR2 5NDD
TM5 214 T 5.59x59 PAR2 5NDD CysLT1 receptor 6RZ4
TM5 215 A 5.60x60 PAR2 5NDD DP2 receptor 7M8W
TM5 216 T 5.61x61 PAR2 5NDD 5-HT2B receptor 5TVN
TM5 217 I 5.62x62 PAR2 5NDD PAR2 5NDD
TM5 218 L 5.63x63 PAR2 5NDD CysLT1 receptor 6RZ4
TM5 219 K 5.64x64 PAR2 5NDD GPR52 6LI1
TM5 220 L 5.65x65 PAR2 5NDD PAR2 5NDD
TM5 221 L 5.66x66 PAR1 3VW7 CysLT2 receptor 6RZ6
TM5 222 R 5.67x67 PAR1 3VW7 CCR5 7F1T
ICL3 223 T - - - - -
ICL3 224 E - - - - -
ICL3 225 E - - - - -
ICL3 226 A - - - - -
ICL3 227 H - - - - -
TM6 228 G 6.26x27 PAR2 5NDD CXCR4 3ODU
TM6 229 R 6.27x28 PAR2 5NDD PAR1 3VW7
TM6 230 E 6.28x29 PAR2 5NDD Y1 receptor 5ZBH
TM6 231 Q 6.29x30 PAR2 5NDD - -
TM6 232 R 6.30x31 PAR2 5NDD PAR2 5NDD
TM6 233 R 6.31x32 PAR2 5NDD P2Y1 receptor 4XNW
TM6 234 R 6.32x33 PAR2 5NDD PAR2 5NDD
TM6 235 A 6.33x34 PAR2 5NDD PAR2 5NDD
TM6 236 V 6.34x35 PAR2 5NDD MT1 receptor 6ME2
TM6 237 G 6.35x36 PAR2 5NDD CysLT1 receptor 6RZ4
TM6 238 L 6.36x37 PAR2 5NDD PAR2 5NDD
TM6 239 A 6.37x38 PAR2 5NDD PAR2 5NDD
TM6 240 A 6.38x39 PAR2 5NDD PAR1 3VW7
TM6 241 V 6.39x40 PAR2 5NDD CysLT1 receptor 6RZ4
TM6 242 V 6.40x41 PAR2 5NDD PAR2 5NDD
TM6 243 L 6.41x42 PAR2 5NDD P2Y1 receptor 4XNW
TM6 244 L 6.42x43 PAR2 5NDD FFA1 receptor 5TZY
TM6 245 A 6.43x44 PAR2 5NDD CysLT1 receptor 6RZ4
TM6 246 F 6.44x45 PAR2 5NDD PAR1 3VW7
TM6 247 V 6.45x46 PAR2 5NDD succinate receptor 6RNK
TM6 248 T 6.46x461 PAR2 5NDD - -
TM6 249 C 6.47x47 PAR2 5NDD PAR2 5NDD
TM6 250 F 6.48x48 PAR2 5NDD PAR2 5NDD
TM6 251 A 6.49x49 PAR2 5NDD MC4 receptor 6W25
TM6 252 P 6.50x50 PAR2 5NDD PAR2 5NDD
TM6 253 N 6.51x51 PAR2 5NDD - -
TM6 254 N 6.52x52 PAR2 5NDD PAR2 5NDD
TM6 255 F 6.53x53 PAR2 5NDD P2Y12 receptor 4NTJ
TM6 256 V 6.54x54 PAR2 5NDD PAF receptor 5ZKQ
TM6 257 L 6.55x55 PAR2 5NDD PAR2 5NDD
TM6 258 L 6.56x56 PAR2 5NDD PAF receptor 5ZKQ
TM6 259 A 6.57x57 PAR2 5NDD PAR1 3VW7
TM6 260 H 6.58x58 PAR2 5NDD PAR2 5NDD
TM6 261 I 6.59x59 PAR2 5NDD succinate receptor 6RNK
TM6 262 V 6.60x60 PAR2 5NDD FPR2/ALX 6OMM
TM6 263 S 6.61x61 PAR2 5NDD P2Y12 receptor 4PXZ
ECL3 264 R - - - - -
ECL3 265 L - GnRH1 receptor 7BR3 - -
ECL3 266 F - GnRH1 receptor 7BR3 - -
ECL3 267 Y - GnRH1 receptor 7BR3 - -
ECL3 268 G - GnRH1 receptor 7BR3 - -
ECL3 269 K - GnRH1 receptor 7BR3 - -
ECL3 270 S - - - - -
TM7 271 Y 7.31x30 PAR2 5NDD Y2 receptor 7DDZ
TM7 272 Y 7.32x31 PAR2 5NDD PAR2 5NDD
TM7 273 H 7.33x32 PAR2 5NDD H1 receptor 3RZE
TM7 274 V 7.34x33 PAR2 5NDD P2Y12 receptor 4NTJ
TM7 275 Y 7.35x34 PAR2 5NDD PAR2 5NDD
TM7 276 K 7.36x35 PAR2 5NDD FFA1 receptor 5TZY
TM7 277 L 7.37x36 PAR2 5NDD PAR1 3VW7
TM7 278 T 7.38x37 PAR2 5NDD P2Y1 receptor 4XNW
TM7 279 L 7.39x38 PAR2 5NDD PAR2 5NDD
TM7 280 C 7.40x39 PAR2 5NDD PAR2 5NDD
TM7 281 L 7.41x40 PAR2 5NDD PAR2 5NDD
TM7 282 S 7.42x41 PAR2 5NDD PAR2 5NDD
TM7 283 C 7.43x42 PAR2 5NDD CCR7 6QZH
TM7 284 L 7.44x43 PAR2 5NDD PAR2 5NDD
TM7 285 N 7.45x45 PAR2 5NDD PAR2 5NDD
TM7 286 N 7.46x46 PAR2 5NDD AT1 receptor 4ZUD
TM7 287 C 7.47x47 PAR2 5NDD PAR2 5NDD
TM7 288 L 7.48x48 PAR2 5NDD PAF receptor 5ZKQ
TM7 289 D 7.49x49 PAR2 5NDD PAR2 5NDD
TM7 290 P 7.50x50 PAR2 5NDD PAR2 5NDD
TM7 291 F 7.51x51 PAR2 5NDD PAR2 5NDD
TM7 292 V 7.52x52 PAR2 5NDD PAR2 5NDD
TM7 293 Y 7.53x53 PAR2 5NDD PAR2 5NDD
TM7 294 Y 7.54x54 PAR2 5NDD PAR2 5NDD
TM7 295 F 7.55x55 PAR2 5NDD PAR2 5NDD
TM7 296 A 7.56x56 PAR2 5NDD CysLT2 receptor 6RZ6
H8 297 S 8.47x47 PAR2 5NDD PAR2 5NDD
H8 298 R 8.48x48 PAR2 5NDD TP receptor 6IIV
H8 299 E 8.49x49 PAR2 5NDD MC4 receptor 6W25
H8 300 F 8.50x50 PAR2 5NDD PAR2 5NDD
H8 301 Q 8.51x51 PAR2 5NDD AT2 receptor 5UNF
H8 302 L 8.52x52 PAR2 5NDD GPR52 6LI1
H8 303 R 8.53x53 PAR2 5NDD CysLT2 receptor 6RZ6
H8 304 L 8.54x54 PAR2 5NDD CysLT2 receptor 6RZ6
H8 305 R 8.55x55 PAR2 5NDD GPR52 6LI1
H8 306 E 8.56x56 PAR2 5NDD MC4 receptor 6W25
H8 307 Y 8.57x57 PAR2 5NDD 5-HT2B receptor 5TVN
H8 308 L 8.58x58 PAR2 5NDD PAR2 5NDD
H8 309 G 8.59x59 CXCR2 6LFL ghrelin receptor 6KO5
H8 310 C 8.60x60 CXCR2 6LFL MC4 receptor 6W25
H8 311 R 8.61x61 CXCR2 6LFL - -
C-term 312 R - - - - -
C-term 313 V - - - - -
C-term 314 P - - - - -
C-term 315 R - - - - -
C-term 316 D - - - - -