PAR3 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

PAR3

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-11-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

PAR2 (sequence similarity: 40%) PDB: 5NDD
Align

TEMPLATES

5NDD (PAR2)
5O9H (C5a1 receptor)
4XNW (P2Y1 receptor)
5ZBH (Y1 receptor)
6RZ6 (CysLT2 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 80.9 11.0 8.2
Side-chains 34.0 45.7 20.2

Number of backbone templates: 5
Number of rotamer templates: 35

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 85 M - PAR2 5NDD PAR2 5NDD
N-term 86 G - PAR2 5NDD PAR2 5NDD
N-term 87 Y - PAR2 5NDD PAR2 5NDD
N-term 88 L - PAR2 5NDD PAR2 5NDD
N-term 89 T - PAR2 5NDD PAR2 5NDD
TM1 90 S 1.28x28 PAR2 5NDD α2C-adrenoceptor 6KUW
TM1 91 S 1.29x29 PAR2 5NDD PAR1 3VW7
TM1 92 L 1.30x30 PAR2 5NDD PAR2 5NDD
TM1 93 S 1.31x31 PAR2 5NDD CCR6 6WWZ
TM1 94 T 1.32x32 PAR2 5NDD PAR2 5NDD
TM1 95 K 1.33x33 PAR2 5NDD LPA1 receptor 4Z35
TM1 96 L 1.34x34 PAR2 5NDD LPA6 receptor 5XSZ
TM1 97 I 1.35x35 PAR2 5NDD apelin receptor 5VBL
TM1 98 P 1.36x36 PAR2 5NDD PAR2 5NDD
TM1 99 A 1.37x37 PAR2 5NDD P2Y1 receptor 4XNW
TM1 100 I 1.38x38 PAR2 5NDD CXCR2 6LFL
TM1 101 Y 1.39x39 PAR2 5NDD PAR2 5NDD
TM1 102 L 1.40x40 PAR2 5NDD CysLT2 receptor 6RZ6
TM1 103 L 1.41x41 PAR2 5NDD P2Y1 receptor 4XNW
TM1 104 V 1.42x42 PAR2 5NDD PAR2 5NDD
TM1 105 F 1.43x43 PAR2 5NDD PAR2 5NDD
TM1 106 V 1.44x44 PAR2 5NDD PAR2 5NDD
TM1 107 V 1.45x45 PAR2 5NDD PAR2 5NDD
TM1 108 G 1.46x46 PAR2 5NDD P2Y1 receptor 4XNW
TM1 109 V 1.47x47 PAR2 5NDD CysLT2 receptor 6RZ6
TM1 110 P 1.48x48 PAR2 5NDD PAR2 5NDD
TM1 111 A 1.49x49 PAR2 5NDD PAF receptor 5ZKQ
TM1 112 N 1.50x50 PAR2 5NDD PAR2 5NDD
TM1 113 A 1.51x51 PAR2 5NDD C5a1 receptor 6C1Q
TM1 114 V 1.52x52 PAR2 5NDD P2Y1 receptor 4XNW
TM1 115 T 1.53x53 PAR2 5NDD ghrelin receptor 6KO5
TM1 116 L 1.54x54 PAR2 5NDD PAR2 5NDD
TM1 117 W 1.55x55 PAR2 5NDD PAR2 5NDD
TM1 118 M 1.56x56 PAR2 5NDD P2Y1 receptor 4XNW
TM1 119 L 1.57x57 PAR2 5NDD CysLT1 receptor 6RZ4
TM1 120 F 1.58x58 PAR2 5NDD P2Y12 receptor 4NTJ
TM1 121 F 1.59x59 PAR2 5NDD PAR2 5NDD
TM1 122 R 1.60x60 PAR2 5NDD PAR2 5NDD
ICL1 123 T - - - - -
ICL1 124 R - C5a1 receptor 5O9H - -
ICL1 125 S - - - - -
TM2 126 I 2.37x37 PAR2 5NDD - -
TM2 127 C 2.38x38 PAR2 5NDD - -
TM2 128 T 2.39x39 PAR2 5NDD LPA6 receptor 5XSZ
TM2 129 T 2.40x40 PAR2 5NDD LPA6 receptor 5XSZ
TM2 130 V 2.41x41 PAR2 5NDD PAR1 3VW7
TM2 131 F 2.42x42 PAR2 5NDD CysLT2 receptor 6RZ6
TM2 132 Y 2.43x43 PAR2 5NDD FPR2/ALX 6OMM
TM2 133 T 2.44x44 PAR2 5NDD β2-adrenoceptor 3SN6
TM2 134 N 2.45x45 PAR2 5NDD PAR2 5NDD
TM2 135 L 2.46x46 PAR2 5NDD PAR2 5NDD
TM2 136 A 2.47x47 PAR2 5NDD PAR2 5NDD
TM2 137 I 2.48x48 PAR2 5NDD CysLT2 receptor 6RZ6
TM2 138 A 2.49x49 PAR2 5NDD PAR2 5NDD
TM2 139 D 2.50x50 PAR2 5NDD PAR2 5NDD
TM2 140 F 2.51x51 PAR2 5NDD P2Y1 receptor 4XNW
TM2 141 L 2.52x52 PAR2 5NDD PAR2 5NDD
TM2 142 F 2.53x53 PAR2 5NDD PAR1 3VW7
TM2 143 C 2.54x54 PAR2 5NDD C5a1 receptor 6C1Q
TM2 144 V 2.55x55 PAR2 5NDD FFA1 receptor 5TZY
TM2 145 T 2.56x56 PAR2 5NDD P2Y1 receptor 4XNW
TM2 146 L 2.57x57 PAR2 5NDD PAR1 3VW7
TM2 147 P 2.58x58 PAR2 5NDD PAR2 5NDD
TM2 148 F 2.59x59 PAR2 5NDD PAR1 3VW7
TM2 149 K 2.60x60 PAR2 5NDD PAR2 5NDD
TM2 150 I 2.61x61 PAR2 5NDD PAR2 5NDD
TM2 151 A 2.62x62 PAR2 5NDD PAR2 5NDD
TM2 152 Y 2.63x63 PAR2 5NDD PAR2 5NDD
TM2 153 H 2.64x64 PAR2 5NDD PAR2 5NDD
TM2 154 L 2.65x65 PAR2 5NDD CysLT2 receptor 6RZ6
TM2 155 N 2.66x66 PAR2 5NDD P2Y1 receptor 4XNW
ECL1 156 G - PAR2 5NDD PAR2 5NDD
ECL1 157 N - PAR2 5NDD PAR2 5NDD
ECL1 158 N 23.49x49 PAR2 5NDD PAR2 5NDD
ECL1 159 W 23.50x50 PAR2 5NDD PAR2 5NDD
ECL1 160 V 23.51x51 PAR2 5NDD CCR2 5T1A
ECL1 161 F 23.52x52 PAR2 5NDD PAR1 3VW7
TM3 162 G 3.21x21 PAR2 5NDD PAR2 5NDD
TM3 163 E 3.22x22 PAR2 5NDD PAR2 5NDD
TM3 164 V 3.23x23 PAR2 5NDD succinate receptor 6RNK
TM3 165 L 3.24x24 PAR2 5NDD PAR2 5NDD
TM3 166 C 3.25x25 PAR2 5NDD PAR2 5NDD
TM3 167 R 3.26x26 PAR2 5NDD PAR1 3VW7
TM3 168 A 3.27x27 PAR2 5NDD 5-HT2B receptor 5TVN
TM3 169 T 3.28x28 PAR2 5NDD P2Y12 receptor 4NTJ
TM3 170 T 3.29x29 PAR2 5NDD PAR1 3VW7
TM3 171 V 3.30x30 PAR2 5NDD P2Y12 receptor 4NTJ
TM3 172 I 3.31x31 PAR2 5NDD P2Y1 receptor 4XNW
TM3 173 F 3.32x32 PAR2 5NDD PAR2 5NDD
TM3 174 Y 3.33x33 PAR2 5NDD PAR2 5NDD
TM3 175 G 3.34x34 PAR2 5NDD - -
TM3 176 N 3.35x35 PAR2 5NDD PAR2 5NDD
TM3 177 M 3.36x36 PAR2 5NDD PAR2 5NDD
TM3 178 Y 3.37x37 PAR2 5NDD PAR2 5NDD
TM3 179 C 3.38x38 PAR2 5NDD PAR2 5NDD
TM3 180 S 3.39x39 PAR2 5NDD PAR2 5NDD
TM3 181 I 3.40x40 PAR2 5NDD PAR2 5NDD
TM3 182 L 3.41x41 PAR2 5NDD PAR2 5NDD
TM3 183 L 3.42x42 PAR2 5NDD PAR1 3VW7
TM3 184 L 3.43x43 PAR2 5NDD PAR2 5NDD
TM3 185 A 3.44x44 PAR2 5NDD FFA1 receptor 5TZY
TM3 186 C 3.45x45 PAR2 5NDD PAR2 5NDD
TM3 187 I 3.46x46 PAR2 5NDD PAR1 3VW7
TM3 188 S 3.47x47 PAR2 5NDD PAR2 5NDD
TM3 189 I 3.48x48 PAR2 5NDD PAR1 3VW7
TM3 190 N 3.49x49 PAR2 5NDD PAF receptor 5ZKQ
TM3 191 R 3.50x50 PAR2 5NDD PAR2 5NDD
TM3 192 Y 3.51x51 PAR2 5NDD P2Y1 receptor 4XNW
TM3 193 L 3.52x52 PAR2 5NDD PAR1 3VW7
TM3 194 A 3.53x53 PAR2 5NDD PAR1 3VW7
TM3 195 I 3.54x54 PAR2 5NDD PAR2 5NDD
TM3 196 V 3.55x55 PAR2 5NDD PAR2 5NDD
TM3 197 H 3.56x56 PAR2 5NDD CysLT2 receptor 6RZ6
ICL2 198 P 34.50x50 - - - -
ICL2 199 F 34.51x51 P2Y1 receptor 4XNW LPA6 receptor 5XSZ
ICL2 200 T 34.52x52 P2Y1 receptor 4XNW M2 receptor 5YC8
ICL2 201 Y 34.53x53 P2Y1 receptor 4XNW FFA1 receptor 5TZY
ICL2 202 R 34.54x54 P2Y1 receptor 4XNW LPA6 receptor 5XSZ
ICL2 203 G 34.55x55 P2Y1 receptor 4XNW P2Y1 receptor 4XNW
ICL2 204 L 34.56x56 P2Y1 receptor 4XNW LPA6 receptor 5XSZ
ICL2 205 P 34.57x57 - - - -
TM4 206 K 4.38x38 PAR2 5NDD PAR2 5NDD
TM4 207 H 4.39x39 PAR2 5NDD - -
TM4 208 T 4.40x40 PAR2 5NDD CCR5 4MBS
TM4 209 Y 4.41x41 PAR2 5NDD FFA1 receptor 5TZY
TM4 210 A 4.42x42 PAR2 5NDD PAR2 5NDD
TM4 211 L 4.43x43 PAR2 5NDD MT1 receptor 6ME2
TM4 212 V 4.44x44 PAR2 5NDD CXCR4 3ODU
TM4 213 T 4.45x45 PAR2 5NDD PAR1 3VW7
TM4 214 C 4.46x46 PAR2 5NDD PAR1 3VW7
TM4 215 G 4.47x47 PAR2 5NDD CysLT2 receptor 6RZ6
TM4 216 L 4.48x48 PAR2 5NDD P2Y1 receptor 4XNW
TM4 217 V 4.49x49 PAR2 5NDD P2Y1 receptor 4XNW
TM4 218 W 4.50x50 PAR2 5NDD PAR2 5NDD
TM4 219 A 4.51x51 PAR2 5NDD PAR1 3VW7
TM4 220 T 4.52x52 PAR2 5NDD - -
TM4 221 V 4.53x53 PAR2 5NDD P2Y1 receptor 4XNW
TM4 222 F 4.54x54 PAR2 5NDD P2Y12 receptor 4NTJ
TM4 223 L 4.55x55 PAR2 5NDD PAR2 5NDD
TM4 224 Y 4.56x56 PAR2 5NDD - -
TM4 225 M 4.57x57 PAR2 5NDD OX2 receptor 5WQC
TM4 226 L 4.58x59 PAR2 5NDD succinate receptor 6RNK
TM4 227 P 4.59x60 PAR2 5NDD PAR2 5NDD
TM4 228 F 4.60x61 PAR2 5NDD CysLT1 receptor 6RZ4
TM4 229 F 4.61x62 PAR2 5NDD P2Y1 receptor 4XNW
TM4 230 I 4.62x63 PAR2 5NDD 5-HT2B receptor 5TVN
ECL2 231 L - - - - -
ECL2 232 K - Y1 receptor 5ZBH - -
ECL2 233 Q - Y1 receptor 5ZBH - -
ECL2 234 E - Y1 receptor 5ZBH - -
ECL2 235 Y - Y1 receptor 5ZBH - -
ECL2 236 Y - Y1 receptor 5ZBH - -
ECL2 237 L - Y1 receptor 5ZBH - -
ECL2 238 V - Y1 receptor 5ZBH - -
ECL2 239 Q - Y1 receptor 5ZBH - -
ECL2 240 P - Y1 receptor 5ZBH - -
ECL2 241 D - Y1 receptor 5ZBH - -
ECL2 242 I - Y1 receptor 5ZBH - -
ECL2 243 T - Y1 receptor 5ZBH - -
ECL2 244 T - Y1 receptor 5ZBH - -
ECL2 245 C - Y1 receptor 5ZBH - -
ECL2 246 H - Y1 receptor 5ZBH - -
ECL2 247 D - Y1 receptor 5ZBH Y1 receptor 5ZBH
ECL2 248 V - Y1 receptor 5ZBH - -
ECL2 249 H - Y1 receptor 5ZBH - -
ECL2 250 N - Y1 receptor 5ZBH - -
ECL2 251 T - - - - -
ECL2 252 C 45.50x50 PAR2 5NDD PAR2 5NDD
ECL2 253 E 45.51x51 PAR2 5NDD - -
ECL2 254 S 45.52x52 PAR2 5NDD GPBA receptor 7CFN
ECL2 255 S - - - - -
ECL2 256 S - CysLT2 receptor 6RZ6 - -
ECL2 257 P - CysLT2 receptor 6RZ6 - -
ECL2 258 F - - - - -
TM5 259 Q 5.35x36 PAR2 5NDD DP2 receptor 7M8W
TM5 260 L 5.36x37 PAR2 5NDD succinate receptor 6RNK
TM5 261 Y 5.37x38 PAR2 5NDD PAR1 3VW7
TM5 262 Y 5.38x39 PAR2 5NDD PAR2 5NDD
TM5 263 F 5.39x40 PAR2 5NDD PAR2 5NDD
TM5 264 I 5.40x41 PAR2 5NDD LPA6 receptor 5XSZ
TM5 265 S 5.41x42 PAR2 5NDD PAR2 5NDD
TM5 266 L 5.42x43 PAR2 5NDD PAR2 5NDD
TM5 267 A 5.43x44 PAR2 5NDD PAR2 5NDD
TM5 268 F 5.44x45 PAR2 5NDD CysLT1 receptor 6RZ4
TM5 269 F 5.45x46 PAR2 5NDD PAR1 3VW7
TM5 270 G 5.46x461 PAR2 5NDD CysLT2 receptor 6RZ6
TM5 271 F 5.47x47 PAR2 5NDD PAR2 5NDD
TM5 272 L 5.48x48 PAR2 5NDD PAR2 5NDD
TM5 273 I 5.49x49 PAR2 5NDD LPA6 receptor 5XSZ
TM5 274 P 5.50x50 PAR2 5NDD PAR2 5NDD
TM5 275 F 5.51x51 PAR2 5NDD CysLT2 receptor 6RZ6
TM5 276 V 5.52x52 PAR2 5NDD P2Y1 receptor 4XNW
TM5 277 L 5.53x53 PAR2 5NDD PAR2 5NDD
TM5 278 I 5.54x54 PAR2 5NDD P2Y1 receptor 4XNW
TM5 279 I 5.55x55 PAR2 5NDD CysLT1 receptor 6RZ4
TM5 280 Y 5.56x56 PAR2 5NDD US28 5WB1
TM5 281 C 5.57x57 PAR2 5NDD PAR1 3VW7
TM5 282 Y 5.58x58 PAR2 5NDD PAR2 5NDD
TM5 283 A 5.59x59 PAR2 5NDD LPA6 receptor 5XSZ
TM5 284 A 5.60x60 PAR2 5NDD DP2 receptor 7M8W
TM5 285 I 5.61x61 PAR2 5NDD PAR1 3VW7
TM5 286 I 5.62x62 PAR2 5NDD PAR2 5NDD
TM5 287 R 5.63x63 PAR2 5NDD PAR2 5NDD
TM5 288 T 5.64x64 PAR2 5NDD LPA6 receptor 5XSZ
TM5 289 L 5.65x65 PAR2 5NDD PAR2 5NDD
TM5 290 N 5.66x66 P2Y1 receptor 4XNW - -
TM5 291 A 5.67x67 P2Y1 receptor 4XNW BLT1 receptor 5X33
TM5 292 Y 5.68x68 P2Y1 receptor 4XNW - -
ICL3 293 D - - - - -
ICL3 294 H - - - - -
ICL3 295 R - - - - -
TM6 296 W 6.30x31 PAR2 5NDD GPBA receptor 7CFN
TM6 297 L 6.31x32 PAR2 5NDD FFA1 receptor 5TZY
TM6 298 W 6.32x33 PAR2 5NDD - -
TM6 299 Y 6.33x34 PAR2 5NDD - -
TM6 300 V 6.34x35 PAR2 5NDD MT1 receptor 6ME2
TM6 301 K 6.35x36 PAR2 5NDD PAR2 5NDD
TM6 302 A 6.36x37 PAR2 5NDD AT2 receptor 5UNG
TM6 303 S 6.37x38 PAR2 5NDD PAR1 3VW7
TM6 304 L 6.38x39 PAR2 5NDD succinate receptor 6RNK
TM6 305 L 6.39x40 PAR2 5NDD MC4 receptor 6W25
TM6 306 I 6.40x41 PAR2 5NDD P2Y12 receptor 4NTJ
TM6 307 L 6.41x42 PAR2 5NDD P2Y1 receptor 4XNW
TM6 308 V 6.42x43 PAR2 5NDD TP receptor 6IIV
TM6 309 I 6.43x44 PAR2 5NDD PAR1 3VW7
TM6 310 F 6.44x45 PAR2 5NDD PAR1 3VW7
TM6 311 T 6.45x46 PAR2 5NDD LH receptor 7FIG
TM6 312 I 6.46x461 PAR2 5NDD PAR2 5NDD
TM6 313 C 6.47x47 PAR2 5NDD PAR2 5NDD
TM6 314 F 6.48x48 PAR2 5NDD PAR2 5NDD
TM6 315 A 6.49x49 PAR2 5NDD MC4 receptor 6W25
TM6 316 P 6.50x50 PAR2 5NDD PAR2 5NDD
TM6 317 S 6.51x51 PAR2 5NDD PAR2 5NDD
TM6 318 N 6.52x52 PAR2 5NDD PAR2 5NDD
TM6 319 I 6.53x53 PAR2 5NDD succinate receptor 6RNK
TM6 320 I 6.54x54 PAR2 5NDD MT1 receptor 6ME2
TM6 321 L 6.55x55 PAR2 5NDD PAR2 5NDD
TM6 322 I 6.56x56 PAR2 5NDD PAR1 3VW7
TM6 323 I 6.57x57 PAR2 5NDD CysLT1 receptor 6RZ4
TM6 324 H 6.58x58 PAR2 5NDD PAR2 5NDD
TM6 325 H 6.59x59 PAR2 5NDD - -
TM6 326 A 6.60x60 PAR2 5NDD succinate receptor 6RNK
TM6 327 N 6.61x61 PAR2 5NDD - -
TM6 328 Y 6.62x62 PAR2 5NDD GPBA receptor 7CFN
ECL3 329 Y - - - - -
ECL3 330 Y - - - - -
ECL3 331 N - - - - -
ECL3 332 N - - - - -
ECL3 333 T - - - - -
ECL3 334 D - - - - -
ECL3 335 G - - - - -
TM7 336 L 7.31x30 PAR2 5NDD CysLT2 receptor 6RZ6
TM7 337 Y 7.32x31 PAR2 5NDD PAR2 5NDD
TM7 338 F 7.33x32 PAR2 5NDD PAR1 3VW7
TM7 339 I 7.34x33 PAR2 5NDD LPA6 receptor 5XSZ
TM7 340 Y 7.35x34 PAR2 5NDD PAR2 5NDD
TM7 341 L 7.36x35 PAR2 5NDD PAR1 3VW7
TM7 342 I 7.37x36 PAR2 5NDD CysLT2 receptor 6RZ6
TM7 343 A 7.38x37 PAR2 5NDD PAR2 5NDD
TM7 344 L 7.39x38 PAR2 5NDD PAR2 5NDD
TM7 345 C 7.40x39 PAR2 5NDD PAR2 5NDD
TM7 346 L 7.41x40 PAR2 5NDD PAR2 5NDD
TM7 347 G 7.42x41 PAR2 5NDD FFA1 receptor 5TZY
TM7 348 S 7.43x42 PAR2 5NDD PAR1 3VW7
TM7 349 L 7.44x43 PAR2 5NDD PAR2 5NDD
TM7 350 N 7.45x45 PAR2 5NDD PAR2 5NDD
TM7 351 S 7.46x46 PAR2 5NDD PAR2 5NDD
TM7 352 C 7.47x47 PAR2 5NDD PAR2 5NDD
TM7 353 L 7.48x48 PAR2 5NDD PAF receptor 5ZKQ
TM7 354 D 7.49x49 PAR2 5NDD PAR2 5NDD
TM7 355 P 7.50x50 PAR2 5NDD PAR2 5NDD
TM7 356 F 7.51x51 PAR2 5NDD PAR2 5NDD
TM7 357 L 7.52x52 PAR2 5NDD P2Y1 receptor 4XNW
TM7 358 Y 7.53x53 PAR2 5NDD PAR2 5NDD
TM7 359 F 7.54x54 PAR2 5NDD P2Y1 receptor 4XNW
TM7 360 L 7.55x55 PAR2 5NDD P2Y1 receptor 4XNW
TM7 361 M 7.56x56 PAR2 5NDD ghrelin receptor 6KO5
C-term 362 S - - - - -
C-term 363 K - - - - -
C-term 364 T - - - - -
C-term 365 R - - - - -
C-term 366 N - - - - -