PAR4 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

PAR4

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2022-06-19

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

PAR2 (sequence similarity: 44%) PDB: 5NDD
Align

TEMPLATES

5NDD (PAR2)
5O9H (C5a1 receptor)
7WVX (FPR2/ALX)
6RZ6 (CysLT2 receptor)
6LFL (CXCR2)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 89.2 4.4 6.4
Side-chains 34.1 47.6 18.2

Number of backbone templates: 5
Number of rotamer templates: 47

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 68 R - PAR2 5NDD PAR2 5NDD
N-term 69 A - PAR2 5NDD PAR2 5NDD
N-term 70 L - PAR2 5NDD PAR2 5NDD
N-term 71 L - PAR2 5NDD PAR2 5NDD
N-term 72 L - PAR2 5NDD PAR2 5NDD
TM1 73 G 1.28x28 PAR2 5NDD PAR2 5NDD
TM1 74 W 1.29x29 PAR2 5NDD - -
TM1 75 V 1.30x30 PAR2 5NDD FPR2/ALX 7WVX
TM1 76 P 1.31x31 PAR2 5NDD C5a1 receptor 6C1Q
TM1 77 T 1.32x32 PAR2 5NDD PAR2 5NDD
TM1 78 R 1.33x33 PAR2 5NDD CCR5 4MBS
TM1 79 L 1.34x34 PAR2 5NDD FPR2/ALX 7WVX
TM1 80 V 1.35x35 PAR2 5NDD CXCR2 6LFL
TM1 81 P 1.36x36 PAR2 5NDD PAR2 5NDD
TM1 82 A 1.37x37 PAR2 5NDD κ receptor 4DJH
TM1 83 L 1.38x38 PAR2 5NDD AT1 receptor 4ZUD
TM1 84 Y 1.39x39 PAR2 5NDD PAR2 5NDD
TM1 85 G 1.40x40 PAR2 5NDD FPR2/ALX 7WVX
TM1 86 L 1.41x41 PAR2 5NDD CXCR2 6LFL
TM1 87 V 1.42x42 PAR2 5NDD PAR2 5NDD
TM1 88 L 1.43x43 PAR2 5NDD BLT1 receptor 7K15
TM1 89 V 1.44x44 PAR2 5NDD PAR2 5NDD
TM1 90 V 1.45x45 PAR2 5NDD PAR2 5NDD
TM1 91 G 1.46x46 PAR2 5NDD FPR2/ALX 7WVX
TM1 92 L 1.47x47 PAR2 5NDD PAR2 5NDD
TM1 93 P 1.48x48 PAR2 5NDD PAR2 5NDD
TM1 94 A 1.49x49 PAR2 5NDD GPR139 7VUG
TM1 95 N 1.50x50 PAR2 5NDD PAR2 5NDD
TM1 96 G 1.51x51 PAR2 5NDD PAR2 5NDD
TM1 97 L 1.52x52 PAR2 5NDD FPR2/ALX 7WVX
TM1 98 A 1.53x53 PAR2 5NDD PAR2 5NDD
TM1 99 L 1.54x54 PAR2 5NDD PAR2 5NDD
TM1 100 W 1.55x55 PAR2 5NDD PAR2 5NDD
TM1 101 V 1.56x56 PAR2 5NDD PAR2 5NDD
TM1 102 L 1.57x57 PAR2 5NDD GAL1 receptor 7WQ3
TM1 103 A 1.58x58 PAR2 5NDD GAL1 receptor 7WQ3
TM1 104 T 1.59x59 PAR2 5NDD D4 receptor 5WIV
TM1 105 Q 1.60x60 PAR2 5NDD CXCR4 3ODU
ICL1 106 A - - - - -
ICL1 107 P - C5a1 receptor 5O9H - -
ICL1 108 R - - - - -
TM2 109 L 2.37x37 PAR2 5NDD - -
TM2 110 P 2.38x38 PAR2 5NDD PAR2 5NDD
TM2 111 S 2.39x39 PAR2 5NDD AT2 receptor 5UNG
TM2 112 T 2.40x40 PAR2 5NDD FPR2/ALX 7WVX
TM2 113 M 2.41x41 PAR2 5NDD CCR9 5LWE
TM2 114 L 2.42x42 PAR2 5NDD Y1 receptor 5ZBH
TM2 115 L 2.43x43 PAR2 5NDD CXCR2 6LFL
TM2 116 M 2.44x44 PAR2 5NDD β1-adrenoceptor 7BVQ
TM2 117 N 2.45x45 PAR2 5NDD PAR2 5NDD
TM2 118 L 2.46x46 PAR2 5NDD PAR2 5NDD
TM2 119 A 2.47x47 PAR2 5NDD PAR2 5NDD
TM2 120 A 2.48x48 PAR2 5NDD US28 5WB1
TM2 121 A 2.49x49 PAR2 5NDD PAR2 5NDD
TM2 122 D 2.50x50 PAR2 5NDD PAR2 5NDD
TM2 123 L 2.51x51 PAR2 5NDD PAR2 5NDD
TM2 124 L 2.52x52 PAR2 5NDD PAR2 5NDD
TM2 125 L 2.53x53 PAR2 5NDD AT2 receptor 5UNG
TM2 126 A 2.54x54 PAR2 5NDD CXCR2 6LFL
TM2 127 L 2.55x55 PAR2 5NDD CXCR2 6LFL
TM2 128 A 2.56x56 PAR2 5NDD C5a1 receptor 6C1Q
TM2 129 L 2.57x57 PAR2 5NDD FPR2/ALX 7WVX
TM2 130 P 2.58x58 PAR2 5NDD PAR2 5NDD
TM2 131 P 2.59x59 PAR2 5NDD V2 receptor 7KH0
TM2 132 R 2.60x60 PAR2 5NDD GPR183 7TUZ
TM2 133 I 2.61x61 PAR2 5NDD PAR2 5NDD
TM2 134 A 2.62x62 PAR2 5NDD PAR2 5NDD
TM2 135 Y 2.63x63 PAR2 5NDD PAR2 5NDD
TM2 136 H 2.64x64 PAR2 5NDD PAR2 5NDD
TM2 137 L 2.65x65 PAR2 5NDD κ receptor 4DJH
TM2 138 R 2.66x66 PAR2 5NDD apelin receptor 5VBL
ECL1 139 G - PAR2 5NDD PAR2 5NDD
ECL1 140 Q - PAR2 5NDD - -
ECL1 141 R 23.49x49 PAR2 5NDD AT1 receptor 4ZUD
ECL1 142 W 23.50x50 PAR2 5NDD PAR2 5NDD
ECL1 143 P 23.51x51 PAR2 5NDD FPR2/ALX 7WVX
ECL1 144 F 23.52x52 PAR2 5NDD CXCR2 6LFL
TM3 145 G 3.21x21 PAR2 5NDD PAR2 5NDD
TM3 146 E 3.22x22 PAR2 5NDD PAR2 5NDD
TM3 147 A 3.23x23 PAR2 5NDD PAR2 5NDD
TM3 148 A 3.24x24 PAR2 5NDD C5a1 receptor 6C1Q
TM3 149 C 3.25x25 PAR2 5NDD PAR2 5NDD
TM3 150 R 3.26x26 PAR2 5NDD SST2 receptor 7T10
TM3 151 L 3.27x27 PAR2 5NDD FPR2/ALX 7WVX
TM3 152 A 3.28x28 PAR2 5NDD AT1 receptor 4ZUD
TM3 153 T 3.29x29 PAR2 5NDD CCR5 4MBS
TM3 154 A 3.30x30 PAR2 5NDD AT1 receptor 4ZUD
TM3 155 A 3.31x31 PAR2 5NDD Y2 receptor 7DDZ
TM3 156 L 3.32x32 PAR2 5NDD AT2 receptor 5UNG
TM3 157 Y 3.33x33 PAR2 5NDD PAR2 5NDD
TM3 158 G 3.34x34 PAR2 5NDD - -
TM3 159 H 3.35x35 PAR2 5NDD - -
TM3 160 M 3.36x36 PAR2 5NDD PAR2 5NDD
TM3 161 Y 3.37x37 PAR2 5NDD PAR2 5NDD
TM3 162 G 3.38x38 PAR2 5NDD FPR2/ALX 7WVX
TM3 163 S 3.39x39 PAR2 5NDD PAR2 5NDD
TM3 164 V 3.40x40 PAR2 5NDD FPR2/ALX 7WVX
TM3 165 L 3.41x41 PAR2 5NDD PAR2 5NDD
TM3 166 L 3.42x42 PAR2 5NDD FPR2/ALX 7WVX
TM3 167 L 3.43x43 PAR2 5NDD CXCR2 6LFL
TM3 168 A 3.44x44 PAR2 5NDD CXCR2 6LFL
TM3 169 A 3.45x45 PAR2 5NDD GAL1 receptor 7WQ3
TM3 170 V 3.46x46 PAR2 5NDD GAL2 receptor 7WQ4
TM3 171 S 3.47x47 PAR2 5NDD PAR2 5NDD
TM3 172 L 3.48x48 PAR2 5NDD FPR2/ALX 7WVX
TM3 173 D 3.49x49 PAR2 5NDD FPR2/ALX 7WVX
TM3 174 R 3.50x50 PAR2 5NDD PAR2 5NDD
TM3 175 Y 3.51x51 PAR2 5NDD CXCR2 6LFL
TM3 176 L 3.52x52 PAR2 5NDD CXCR2 6LFL
TM3 177 A 3.53x53 PAR2 5NDD CXCR2 6LFL
TM3 178 L 3.54x54 PAR2 5NDD B1 receptor 7EIB
TM3 179 V 3.55x55 PAR2 5NDD PAR2 5NDD
TM3 180 H 3.56x56 PAR2 5NDD FPR2/ALX 7WVX
ICL2 181 P 34.50x50 - - - -
ICL2 182 L 34.51x51 FPR2/ALX 7WVX GPR183 7TUZ
ICL2 183 R 34.52x52 FPR2/ALX 7WVX CXCR2 6LFO
ICL2 184 A 34.53x53 FPR2/ALX 7WVX FPR2/ALX 7WVX
ICL2 185 R 34.54x54 FPR2/ALX 7WVX AT1 receptor 6DO1
ICL2 186 A 34.55x55 FPR2/ALX 7WVX β3-adrenoceptor 7DH5
ICL2 187 L 34.56x56 FPR2/ALX 7WVX GAL1 receptor 7WQ3
ICL2 188 R 34.57x57 - - - -
TM4 189 G 4.38x38 PAR2 5NDD - -
TM4 190 R 4.39x39 PAR2 5NDD CXCR2 6LFL
TM4 191 R 4.40x40 PAR2 5NDD GAL1 receptor 7WQ3
TM4 192 L 4.41x41 PAR2 5NDD FPR2/ALX 7WVX
TM4 193 A 4.42x42 PAR2 5NDD PAR2 5NDD
TM4 194 L 4.43x43 PAR2 5NDD GAL1 receptor 7WQ3
TM4 195 G 4.44x44 PAR2 5NDD PAR2 5NDD
TM4 196 L 4.45x45 PAR2 5NDD C5a1 receptor 5O9H
TM4 197 C 4.46x46 PAR2 5NDD CXCR2 6LFL
TM4 198 M 4.47x47 PAR2 5NDD BILF1 7JHJ
TM4 199 A 4.48x48 PAR2 5NDD PAR2 5NDD
TM4 200 A 4.49x49 PAR2 5NDD C5a1 receptor 6C1Q
TM4 201 W 4.50x50 PAR2 5NDD PAR2 5NDD
TM4 202 L 4.51x51 PAR2 5NDD PAR2 5NDD
TM4 203 M 4.52x52 PAR2 5NDD FPR1 7WVU
TM4 204 A 4.53x53 PAR2 5NDD FPR2/ALX 7WVX
TM4 205 A 4.54x54 PAR2 5NDD apelin receptor 5VBL
TM4 206 A 4.55x55 PAR2 5NDD GAL1 receptor 7WQ3
TM4 207 L 4.56x56 PAR2 5NDD FPR2/ALX 7WVX
TM4 208 A 4.57x57 PAR2 5NDD CXCR2 6LFL
TM4 209 L 4.58x59 PAR2 5NDD FPR2/ALX 7WVX
TM4 210 P 4.59x60 PAR2 5NDD PAR2 5NDD
TM4 211 L 4.60x61 PAR2 5NDD PAR2 5NDD
TM4 212 T 4.61x62 PAR2 5NDD - -
TM4 213 L 4.62x63 PAR2 5NDD FPR2/ALX 7WVX
ECL2 214 Q - PAR2 5NDD - -
ECL2 215 R - PAR2 5NDD - -
ECL2 216 Q - PAR2 5NDD PAR2 5NDD
ECL2 217 T - PAR2 5NDD PAR2 5NDD
ECL2 218 F - PAR2 5NDD - -
ECL2 219 R - PAR2 5NDD - -
ECL2 220 L - PAR2 5NDD - -
ECL2 221 A - PAR2 5NDD - -
ECL2 222 R - PAR2 5NDD - -
ECL2 223 S - PAR2 5NDD - -
ECL2 224 D - PAR2 5NDD - -
ECL2 225 R - PAR2 5NDD - -
ECL2 226 V - PAR2 5NDD - -
ECL2 227 L - PAR2 5NDD - -
ECL2 228 C 45.50x50 PAR2 5NDD PAR2 5NDD
ECL2 229 H 45.51x51 PAR2 5NDD PAR2 5NDD
ECL2 230 D 45.52x52 PAR2 5NDD PAR2 5NDD
ECL2 231 A - PAR2 5NDD - -
ECL2 232 L - PAR2 5NDD PAR2 5NDD
ECL2 233 P - PAR2 5NDD PAR2 5NDD
ECL2 234 L - PAR2 5NDD - -
ECL2 235 D - PAR2 5NDD - -
ECL2 236 A - PAR2 5NDD - -
TM5 237 Q 5.31x32 PAR2 5NDD NOP receptor 5DHG
TM5 238 A 5.32x33 PAR2 5NDD CXCR2 6LFO
TM5 239 S 5.33x34 PAR2 5NDD DP2 receptor 7M8W
TM5 240 H 5.34x35 PAR2 5NDD GAL1 receptor 7WQ3
TM5 241 W 5.35x36 PAR2 5NDD - -
TM5 242 Q 5.36x37 PAR2 5NDD CCK1 receptor 7F8Y
TM5 243 P 5.37x38 PAR2 5NDD β3-adrenoceptor 7DH5
TM5 244 A 5.38x39 PAR2 5NDD - -
TM5 245 F 5.39x40 PAR2 5NDD PAR2 5NDD
TM5 246 T 5.40x41 PAR2 5NDD CCK1 receptor 7F8Y
TM5 247 C 5.41x42 PAR2 5NDD κ receptor 4DJH
TM5 248 L 5.42x43 PAR2 5NDD PAR2 5NDD
TM5 249 A 5.43x44 PAR2 5NDD PAR2 5NDD
TM5 250 L 5.44x45 PAR2 5NDD CCR1 7VL9
TM5 251 L 5.45x46 PAR2 5NDD SST2 receptor 7T10
TM5 252 G 5.46x461 PAR2 5NDD FPR2/ALX 7WVX
TM5 253 C 5.47x47 PAR2 5NDD MRGPRX4 7S8P
TM5 254 F 5.48x48 PAR2 5NDD CCR6 6WWZ
TM5 255 L 5.49x49 PAR2 5NDD FPR2/ALX 7WVX
TM5 256 P 5.50x50 PAR2 5NDD PAR2 5NDD
TM5 257 L 5.51x51 PAR2 5NDD CXCR2 6LFL
TM5 258 L 5.52x52 PAR2 5NDD CXCR2 6LFL
TM5 259 A 5.53x53 PAR2 5NDD CCR7 6QZH
TM5 260 M 5.54x54 PAR2 5NDD CXCR2 6LFL
TM5 261 L 5.55x55 PAR2 5NDD CXCR2 6LFL
TM5 262 L 5.56x56 PAR2 5NDD SST2 receptor 7T10
TM5 263 C 5.57x57 PAR2 5NDD FPR2/ALX 7WVX
TM5 264 Y 5.58x58 PAR2 5NDD PAR2 5NDD
TM5 265 G 5.59x59 PAR2 5NDD FPR2/ALX 7WVX
TM5 266 A 5.60x60 PAR2 5NDD DP2 receptor 7M8W
TM5 267 T 5.61x61 PAR2 5NDD CXCR2 6LFL
TM5 268 L 5.62x62 PAR2 5NDD CXCR2 6LFL
TM5 269 H 5.63x63 PAR2 5NDD 5-HT2B receptor 5TUD
TM5 270 T 5.64x64 PAR2 5NDD CXCR2 6LFL
TM5 271 L 5.65x65 PAR2 5NDD PAR2 5NDD
TM5 272 A 5.66x66 CysLT2 receptor 6RZ6 apelin receptor 5VBL
TM5 273 A 5.67x67 CysLT2 receptor 6RZ6 BLT1 receptor 7VKT
TM5 274 S 5.68x68 CysLT2 receptor 6RZ6 V2 receptor 7KH0
ICL3 275 G - - - - -
ICL3 276 R - - - - -
ICL3 277 R - - - - -
TM6 278 Y 6.30x31 PAR2 5NDD - -
TM6 279 G 6.31x32 PAR2 5NDD - -
TM6 280 H 6.32x33 PAR2 5NDD EP2 receptor 7CX2
TM6 281 A 6.33x34 PAR2 5NDD PAR2 5NDD
TM6 282 L 6.34x35 PAR2 5NDD NTS1 receptor 4XES
TM6 283 R 6.35x36 PAR2 5NDD - -
TM6 284 L 6.36x37 PAR2 5NDD PAR2 5NDD
TM6 285 T 6.37x38 PAR2 5NDD FPR2/ALX 7WVX
TM6 286 A 6.38x39 PAR2 5NDD FPR2/ALX 7WVX
TM6 287 V 6.39x40 PAR2 5NDD FPR2/ALX 7WVX
TM6 288 V 6.40x41 PAR2 5NDD PAR2 5NDD
TM6 289 L 6.41x42 PAR2 5NDD CXCR2 6LFL
TM6 290 A 6.42x43 PAR2 5NDD PAR2 5NDD
TM6 291 S 6.43x44 PAR2 5NDD - -
TM6 292 A 6.44x45 PAR2 5NDD apelin receptor 5VBL
TM6 293 V 6.45x46 PAR2 5NDD κ receptor 4DJH
TM6 294 A 6.46x461 PAR2 5NDD - -
TM6 295 F 6.47x47 PAR2 5NDD C5a1 receptor 6C1Q
TM6 296 F 6.48x48 PAR2 5NDD PAR2 5NDD
TM6 297 V 6.49x49 PAR2 5NDD Rhodopsin 5W0P
TM6 298 P 6.50x50 PAR2 5NDD PAR2 5NDD
TM6 299 S 6.51x51 PAR2 5NDD PAR2 5NDD
TM6 300 N 6.52x52 PAR2 5NDD PAR2 5NDD
TM6 301 L 6.53x53 PAR2 5NDD PAR2 5NDD
TM6 302 L 6.54x54 PAR2 5NDD PAR2 5NDD
TM6 303 L 6.55x55 PAR2 5NDD PAR2 5NDD
TM6 304 L 6.56x56 PAR2 5NDD FPR2/ALX 7WVX
TM6 305 L 6.57x57 PAR2 5NDD FPR2/ALX 7WVX
TM6 306 H 6.58x58 PAR2 5NDD PAR2 5NDD
TM6 307 Y 6.59x59 PAR2 5NDD PAR2 5NDD
TM6 308 S 6.60x60 PAR2 5NDD BLT1 receptor 5X33
TM6 309 D 6.61x61 PAR2 5NDD CCR9 5LWE
TM6 310 P 6.62x62 PAR2 5NDD - -
ECL3 311 S - - - - -
ECL3 312 P - - - - -
ECL3 313 S - - - - -
ECL3 314 A - - - - -
ECL3 315 W - - - - -
ECL3 316 G - - - - -
ECL3 317 N - - - - -
TM7 318 L 7.31x30 PAR2 5NDD SST2 receptor 7T10
TM7 319 Y 7.32x31 PAR2 5NDD PAR2 5NDD
TM7 320 G 7.33x32 PAR2 5NDD SST2 receptor 7T10
TM7 321 A 7.34x33 PAR2 5NDD CXCR2 6LFL
TM7 322 Y 7.35x34 PAR2 5NDD PAR2 5NDD
TM7 323 V 7.36x35 PAR2 5NDD V2 receptor 7KH0
TM7 324 P 7.37x36 PAR2 5NDD FPR2/ALX 7WVX
TM7 325 S 7.38x37 PAR2 5NDD OX2 receptor 5WQC
TM7 326 L 7.39x38 PAR2 5NDD PAR2 5NDD
TM7 327 A 7.40x39 PAR2 5NDD κ receptor 4DJH
TM7 328 L 7.41x40 PAR2 5NDD PAR2 5NDD
TM7 329 S 7.42x41 PAR2 5NDD PAR2 5NDD
TM7 330 T 7.43x42 PAR2 5NDD PAR2 5NDD
TM7 331 L 7.44x43 PAR2 5NDD PAR2 5NDD
TM7 332 N 7.45x45 PAR2 5NDD PAR2 5NDD
TM7 333 S 7.46x46 PAR2 5NDD PAR2 5NDD
TM7 334 C 7.47x47 PAR2 5NDD PAR2 5NDD
TM7 335 V 7.48x48 PAR2 5NDD GAL1 receptor 7WQ3
TM7 336 D 7.49x49 PAR2 5NDD PAR2 5NDD
TM7 337 P 7.50x50 PAR2 5NDD PAR2 5NDD
TM7 338 F 7.51x51 PAR2 5NDD PAR2 5NDD
TM7 339 I 7.52x52 PAR2 5NDD CXCR2 6LFL
TM7 340 Y 7.53x53 PAR2 5NDD PAR2 5NDD
TM7 341 Y 7.54x54 PAR2 5NDD PAR2 5NDD
TM7 342 Y 7.55x55 PAR2 5NDD A2A receptor 4UHR
TM7 343 V 7.56x56 PAR2 5NDD PAR2 5NDD
H8 344 S 8.47x47 PAR2 5NDD PAR2 5NDD
H8 345 A 8.48x48 PAR2 5NDD NTS1 receptor 4XES
H8 346 E 8.49x49 PAR2 5NDD CCR5 4MBS
H8 347 F 8.50x50 PAR2 5NDD PAR2 5NDD
H8 348 R 8.51x51 PAR2 5NDD PAR2 5NDD
H8 349 D 8.52x52 PAR2 5NDD PAR2 5NDD
H8 350 K 8.53x53 PAR2 5NDD DP2 receptor 7M8W
H8 351 V 8.54x54 PAR2 5NDD B1 receptor 7EIB
H8 352 R 8.55x55 PAR2 5NDD κ receptor 6VI4
H8 353 A 8.56x56 PAR2 5NDD OX2 receptor 5WQC
H8 354 G 8.57x57 PAR2 5NDD - -
H8 355 L 8.58x58 PAR2 5NDD PAR2 5NDD
H8 356 F 8.59x59 CXCR2 6LFL - -
H8 357 Q 8.60x60 CXCR2 6LFL - -
H8 358 R 8.61x61 CXCR2 6LFL M1 receptor 6ZFZ
C-term 359 S - - - - -
C-term 360 P - - - - -
C-term 361 G - - - - -
C-term 362 D - - - - -
C-term 363 T - - - - -