GPRC5A homology model

PROTEIN CLASS

Class C (Glutamate)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-06-10

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

mGlu5 receptor (sequence similarity: 8%) PDB: 6N51

TEMPLATES

6N51 (mGlu5 receptor)
4OO9 (mGlu5 receptor)
4OR2 (mGlu1 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 68.1 7.0 24.8
Side-chains 11.1 13.7 75.2

Number of backbone templates: 3
Number of rotamer templates: 9

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 21 C - - - - -
N-term 22 D - - - - -
N-term 23 K - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 24 A - mGlu5 receptor 6N51 mGlu5 receptor 6N51
N-term 25 E - mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 26 A 1.38x38 mGlu5 receptor 6N51 - -
TM1 27 W 1.39x39 mGlu5 receptor 6N51 - -
TM1 28 G 1.40x40 mGlu5 receptor 6N51 CaS receptor 7DTU
TM1 29 I 1.41x41 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 30 V 1.42x42 mGlu5 receptor 6N51 - -
TM1 31 L 1.43x43 mGlu5 receptor 6N51 CaS receptor 7DTV
TM1 32 E 1.44x44 mGlu5 receptor 6N51 - -
TM1 33 T 1.45x45 mGlu5 receptor 6N51 - -
TM1 34 V 1.46x46 mGlu5 receptor 6N51 - -
TM1 35 A 1.47x47 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 36 T 1.48x48 mGlu5 receptor 6N51 - -
TM1 37 A 1.49x49 mGlu5 receptor 6N51 - -
TM1 38 G 1.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 39 V 1.51x51 mGlu5 receptor 6N51 - -
TM1 40 V 1.52x52 mGlu5 receptor 6N51 GABAB1 6W2Y
TM1 41 T 1.53x53 mGlu5 receptor 6N51 - -
TM1 42 S 1.54x54 mGlu5 receptor 6N51 - -
TM1 43 V 1.55x55 mGlu5 receptor 6N51 GABAB1 6W2Y
TM1 44 A 1.56x56 mGlu5 receptor 6N51 GABAB2 7CA5
TM1 45 F 1.57x57 mGlu5 receptor 6N51 GABAB2 7C7Q
TM1 46 M 1.58x58 mGlu5 receptor 6N51 - -
TM1 47 L 1.59x59 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM1 48 T 1.60x60 mGlu5 receptor 6N51 - -
TM1 49 L 1.61x61 mGlu5 receptor 6N51 - -
TM1 50 P 1.62x62 mGlu5 receptor 6N51 - -
TM1 51 I 1.63x63 mGlu1 receptor 4OR2 mGlu5 receptor 6FFI
TM1 52 L 1.64x64 mGlu1 receptor 4OR2 - -
ICL1 53 V 12.47x47 - - - -
ICL1 54 C 12.48x48 - - - -
ICL1 55 K 12.49x49 - - - -
ICL1 56 V 12.50x50 - - - -
ICL1 57 Q 12.51x51 - - - -
ICL1 58 D 12.52x52 - - - -
ICL1 59 S 12.53x53 - - - -
TM2 60 N 2.31x31 - - - -
TM2 61 R 2.32x32 - - - -
TM2 62 R 2.33x33 - - - -
TM2 63 K 2.34x34 - - - -
TM2 64 M 2.35x35 mGlu5 receptor 6N51 - -
TM2 65 L 2.36x36 mGlu5 receptor 6N51 - -
TM2 66 P 2.37x37 mGlu5 receptor 6N51 - -
TM2 67 T 2.38x38 mGlu5 receptor 6N51 - -
TM2 68 Q 2.39x39 mGlu5 receptor 6N51 - -
TM2 69 F 2.40x40 mGlu5 receptor 6N51 - -
TM2 70 L 2.41x41 mGlu5 receptor 6N51 GABAB2 7C7Q
TM2 71 F 2.42x42 mGlu5 receptor 6N51 - -
TM2 72 L 2.43x43 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 73 L 2.44x44 mGlu5 receptor 6N51 GABAB2 7C7Q
TM2 74 G 2.45x45 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 75 V 2.46x46 mGlu5 receptor 6N51 - -
TM2 76 L 2.47x47 mGlu5 receptor 6N51 - -
TM2 77 G 2.48x48 mGlu5 receptor 6N51 - -
TM2 78 I 2.49x49 mGlu5 receptor 6N51 - -
TM2 79 F 2.50x50 mGlu5 receptor 6N51 - -
TM2 80 G 2.51x51 mGlu5 receptor 6N51 - -
TM2 81 L 2.52x52 mGlu5 receptor 6N51 - -
TM2 82 T 2.53x53 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 83 F 2.54x54 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 84 A 2.55x55 mGlu5 receptor 6N51 - -
TM2 85 F 2.56x56 mGlu1 receptor 4OR2 GABAB2 7C7Q
TM2 86 I 2.57x57 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ECL1 87 I - - - - -
ECL1 88 G - mGlu1 receptor 4OR2 - -
ECL1 89 L - mGlu1 receptor 4OR2 - -
ECL1 90 D - - - - -
TM3 91 G 3.26x26 mGlu5 receptor 6N51 - -
TM3 92 S 3.27x27 mGlu5 receptor 6N51 - -
TM3 93 T 3.28x28 mGlu5 receptor 6N51 - -
TM3 94 G 3.29x29 mGlu5 receptor 6N51 - -
TM3 95 P 3.30x30 mGlu5 receptor 6N51 - -
TM3 96 T 3.31x31 mGlu5 receptor 6N51 - -
TM3 97 R 3.32x32 mGlu5 receptor 6N51 GABAB2 7C7Q
TM3 98 F 3.33x33 mGlu5 receptor 6N51 - -
TM3 99 F 3.34x34 mGlu5 receptor 6N51 - -
TM3 100 L 3.35x35 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM3 101 F 3.36x36 mGlu5 receptor 6N51 - -
TM3 102 G 3.37x37 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 103 I 3.38x38 mGlu5 receptor 6N51 - -
TM3 104 L 3.39x39 mGlu5 receptor 6N51 - -
TM3 105 F 3.40x40 mGlu5 receptor 6N51 GABAB1 6W2Y
TM3 106 S 3.41x41 mGlu5 receptor 6N51 GABAB1 6W2Y
TM3 107 I 3.42x42 mGlu5 receptor 6N51 - -
TM3 108 C 3.43x43 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM3 109 F 3.44x44 mGlu5 receptor 6N51 GABAB2 7C7Q
TM3 110 S 3.45x45 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 111 C 3.46x46 mGlu5 receptor 6N51 - -
TM3 112 L 3.47x47 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 113 L 3.48x48 mGlu5 receptor 6N51 - -
TM3 114 A 3.49x49 mGlu5 receptor 6N51 GABAB2 7CA5
TM3 115 H 3.50x50 mGlu5 receptor 6N51 - -
TM3 116 A 3.51x51 mGlu5 receptor 6N51 - -
TM3 117 V 3.52x52 mGlu5 receptor 6N51 - -
TM3 118 S 3.53x53 mGlu5 receptor 6N51 - -
TM3 119 L 3.54x54 mGlu5 receptor 6N51 - -
TM3 120 T 3.55x55 mGlu5 receptor 6N51 - -
TM3 121 K 3.56x56 mGlu5 receptor 6N51 - -
TM3 122 L 3.57x57 mGlu5 receptor 6N51 - -
TM3 123 V 3.58x58 mGlu5 receptor 6N51 - -
ICL2 124 R - - - - -
ICL2 125 G - - - - -
ICL2 126 R - - - - -
ICL2 127 K - - - - -
ICL2 128 P - - - - -
ICL2 129 L - - - - -
TM4 130 S 4.28x28 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 131 L 4.29x29 mGlu5 receptor 6N51 - -
TM4 132 L 4.30x30 mGlu5 receptor 6N51 - -
TM4 133 V 4.31x31 mGlu5 receptor 6N51 - -
TM4 134 I 4.32x32 mGlu5 receptor 6N51 - -
TM4 135 L 4.33x33 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 136 G 4.34x34 mGlu5 receptor 6N51 - -
TM4 137 L 4.35x35 mGlu5 receptor 6N51 - -
TM4 138 A 4.36x36 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 139 V 4.37x37 mGlu5 receptor 6N51 - -
TM4 140 G 4.38x38 mGlu5 receptor 6N51 GABAB2 7CA5
TM4 141 F 4.39x39 mGlu5 receptor 6N51 - -
TM4 142 S 4.40x40 mGlu5 receptor 6N51 - -
TM4 143 L 4.41x41 mGlu5 receptor 6N51 GABAB2 7C7Q
TM4 144 V 4.42x42 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM4 145 Q 4.43x43 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 146 D 4.44x44 mGlu5 receptor 6N51 - -
TM4 147 V 4.45x45 mGlu5 receptor 6N51 - -
TM4 148 I 4.46x46 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 149 A 4.47x47 mGlu5 receptor 6N51 - -
TM4 150 I 4.48x48 mGlu5 receptor 6N51 GABAB2 7C7Q
TM4 151 E 4.49x49 mGlu5 receptor 6N51 - -
TM4 152 Y 4.50x50 mGlu5 receptor 6N51 - -
TM4 153 I 4.51x51 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM4 154 V 4.52x52 mGlu5 receptor 6N51 - -
TM4 155 L 4.53x53 mGlu5 receptor 6N51 - -
TM4 156 T 4.54x54 mGlu5 receptor 6N51 - -
ECL2 157 M - - - - -
ECL2 158 N - - - - -
ECL2 159 R - - - - -
ECL2 160 T - - - - -
ECL2 161 N - - - - -
ECL2 162 V - - - - -
ECL2 163 N - - - - -
ECL2 164 V - - - - -
ECL2 165 F - - - - -
ECL2 166 S - - - - -
ECL2 167 E - - - - -
ECL2 168 L - - - - -
ECL2 169 S - - - - -
ECL2 170 A - - - - -
ECL2 171 P - - - - -
ECL2 172 R - - - - -
TM5 173 R 5.36x36 mGlu1 receptor 4OR2 - -
TM5 174 N 5.37x37 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 175 E 5.38x38 mGlu5 receptor 6N51 - -
TM5 176 D 5.39x39 mGlu5 receptor 6N51 - -
TM5 177 F 5.40x40 mGlu5 receptor 6N51 - -
TM5 178 V 5.41x41 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 179 L 5.42x42 mGlu5 receptor 6N51 - -
TM5 180 L 5.43x43 mGlu5 receptor 6N51 - -
TM5 181 L 5.44x44 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 182 T 5.45x45 mGlu5 receptor 6N51 - -
TM5 183 Y 5.46x46 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM5 184 V 5.47x47 mGlu5 receptor 6N51 - -
TM5 185 L 5.48x48 mGlu5 receptor 6N51 - -
TM5 186 F 5.49x49 mGlu5 receptor 6N51 - -
TM5 187 L 5.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 188 M 5.51x51 mGlu5 receptor 6N51 GABAB2 7C7Q
TM5 189 A 5.52x52 mGlu5 receptor 6N51 CaS receptor 7DTU
TM5 190 L 5.53x53 mGlu5 receptor 6N51 GABAB1 6W2Y
TM5 191 T 5.54x54 mGlu5 receptor 6N51 - -
TM5 192 F 5.55x55 mGlu5 receptor 6N51 - -
TM5 193 L 5.56x56 mGlu5 receptor 6N51 - -
TM5 194 M 5.57x57 mGlu5 receptor 6N51 - -
TM5 195 S 5.58x58 mGlu5 receptor 6N51 - -
TM5 196 S 5.59x59 mGlu1 receptor 4OR2 - -
TM5 197 F 5.60x60 mGlu1 receptor 4OR2 - -
TM5 198 T 5.61x61 mGlu1 receptor 4OR2 mGlu1 receptor 4OR2
ICL3 199 F - - - - -
ICL3 200 C - - - - -
ICL3 201 G - - - - -
ICL3 202 S - - - - -
ICL3 203 F - - - - -
ICL3 204 T - - - - -
ICL3 205 G - - - - -
ICL3 206 W - - - - -
ICL3 207 K - - - - -
ICL3 208 R - - - - -
TM6 209 H 6.35x35 mGlu5 receptor 6N51 - -
TM6 210 G 6.36x36 mGlu5 receptor 6N51 - -
TM6 211 A 6.37x37 mGlu5 receptor 6N51 - -
TM6 212 H 6.38x38 mGlu5 receptor 6N51 - -
TM6 213 I 6.39x39 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM6 214 Y 6.40x40 mGlu5 receptor 6N51 - -
TM6 215 L 6.41x41 mGlu5 receptor 6N51 - -
TM6 216 T 6.42x42 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 217 M 6.43x43 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 218 L 6.44x44 mGlu5 receptor 6N51 - -
TM6 219 L 6.45x45 mGlu5 receptor 6N51 - -
TM6 220 S 6.46x46 mGlu5 receptor 6N51 - -
TM6 221 I 6.47x47 mGlu5 receptor 6N51 - -
TM6 222 A 6.48x48 mGlu5 receptor 6N51 - -
TM6 223 I 6.49x49 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 224 W 6.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 225 V 6.51x51 mGlu5 receptor 6N51 - -
TM6 226 A 6.52x52 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 227 W 6.53x53 mGlu5 receptor 6N51 - -
TM6 228 I 6.54x54 mGlu5 receptor 6N51 - -
TM6 229 T 6.55x55 mGlu5 receptor 6N51 - -
TM6 230 L 6.56x56 mGlu5 receptor 6N51 - -
TM6 231 L 6.57x57 mGlu5 receptor 6N51 - -
TM6 232 M 6.58x58 mGlu5 receptor 6N51 GABAB1 6W2Y
TM6 233 L 6.59x59 mGlu5 receptor 6N51 GABAB2 7C7Q
TM6 234 P 6.60x60 mGlu5 receptor 4OO9 - -
ECL3 235 D - - - - -
ECL3 236 F - - - - -
ECL3 237 D - - - - -
ECL3 238 R - - - - -
ECL3 239 R - - - - -
TM7 240 W 7.27x28 mGlu1 receptor 4OR2 - -
TM7 241 D 7.28x29 mGlu1 receptor 4OR2 - -
TM7 242 D 7.29x30 mGlu5 receptor 6N51 - -
TM7 243 T 7.30x31 mGlu5 receptor 6N51 - -
TM7 244 I 7.31x32 mGlu5 receptor 6N51 GABAB2 7C7Q
TM7 245 L 7.32x33 mGlu5 receptor 6N51 - -
TM7 246 S 7.33x34 mGlu5 receptor 6N51 - -
TM7 247 S 7.34x35 mGlu5 receptor 6N51 - -
TM7 248 A 7.35x36 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM7 249 L 7.36x37 mGlu5 receptor 6N51 - -
TM7 250 A 7.37x38 mGlu5 receptor 6N51 - -
TM7 251 A 7.38x39 mGlu5 receptor 6N51 CaS receptor 7DTU
TM7 252 N 7.39x40 mGlu5 receptor 6N51 - -
TM7 253 G 7.40x41 mGlu5 receptor 6N51 - -
TM7 254 W 7.41x42 mGlu5 receptor 6N51 - -
TM7 255 V 7.42x43 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 256 F 7.43x44 mGlu5 receptor 6N51 - -
TM7 257 L 7.44x45 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 258 L 7.45x46 mGlu5 receptor 6N51 - -
TM7 259 A 7.46x47 mGlu5 receptor 6N51 - -
TM7 260 Y 7.47x471 mGlu5 receptor 6N51 - -
TM7 261 V 7.48x48 mGlu5 receptor 6N51 - -
TM7 262 S 7.49x49 mGlu5 receptor 6N51 - -
TM7 263 P 7.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 264 E 7.51x51 mGlu5 receptor 6N51 - -
TM7 265 F 7.52x52 mGlu5 receptor 6N51 - -
TM7 266 W 7.53x53 mGlu5 receptor 6N51 - -
TM7 267 L 7.54x54 mGlu5 receptor 6N51 - -
TM7 268 L 7.55x55 mGlu5 receptor 6N51 GABAB2 7C7Q
TM7 269 T 7.56x56 mGlu5 receptor 6N51 - -
TM7 270 K 7.57x57 mGlu1 receptor 4OR2 - -
TM7 271 Q 7.58x58 mGlu1 receptor 4OR2 - -
ICL4 272 R - - - - -
H8 273 N 8.45x45 - - - -
H8 274 P 8.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 275 M 8.47x47 mGlu5 receptor 4OO9 - -
H8 276 D 8.48x48 mGlu5 receptor 4OO9 - -
H8 277 Y 8.49x49 mGlu5 receptor 4OO9 - -
H8 278 P 8.50x50 - - - -
H8 279 V 8.51x51 - - - -
H8 280 E 8.52x52 - - - -
H8 281 D 8.53x53 - - - -
H8 282 A 8.54x54 - - - -
H8 283 F 8.55x55 - - - -
H8 284 C 8.56x56 - - - -
H8 285 K 8.57x57 - - - -
C-term 286 P - - - - -
C-term 287 Q - - - - -
C-term 288 L - - - - -
C-term 289 V - - - - -
C-term 290 K - - - - -