TAS2R16 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

TAS2R16

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-09-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

MC4 receptor (sequence similarity: 20%) PDB: 6W25
Align

TEMPLATES

6D27 (DP2 receptor)
6W25 (MC4 receptor)
6M9T (EP3 receptor)
4DJH (κ receptor)
3VW7 (PAR1)
6I9K (Rhodopsin)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 74.7 17.5 7.7
Side-chains 6.3 61.4 32.3

Number of backbone templates: 6
Number of rotamer templates: 57

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
TM1 7 T 1.32x32 DP2 receptor 6D27 - -
TM1 8 V 1.33x33 DP2 receptor 6D27 κ receptor 4DJH
TM1 9 F 1.34x34 DP2 receptor 6D27 GPR52 6LI1
TM1 10 F 1.35x35 MC4 receptor 6W25 - -
TM1 11 M 1.36x36 MC4 receptor 6W25 μ receptor 5C1M
TM1 12 I 1.37x37 MC4 receptor 6W25 CXCR2 6LFL
TM1 13 I 1.38x38 MC4 receptor 6W25 CXCR2 6LFL
TM1 14 Y 1.39x39 MC4 receptor 6W25 κ receptor 4DJH
TM1 15 V 1.40x40 MC4 receptor 6W25 MC4 receptor 6W25
TM1 16 L 1.41x41 MC4 receptor 6W25 GPR52 6LI1
TM1 17 E 1.42x42 MC4 receptor 6W25 β3-adrenoceptor 7DH5
TM1 18 S 1.43x43 MC4 receptor 6W25 DP2 receptor 6D27
TM1 19 L 1.44x44 MC4 receptor 6W25 DP2 receptor 6D27
TM1 20 T 1.45x45 MC4 receptor 6W25 CXCR4 3ODU
TM1 21 I 1.46x46 MC4 receptor 6W25 GPR52 6LI0
TM1 22 I 1.47x47 MC4 receptor 6W25 GPR52 6LI1
TM1 23 V 1.48x48 MC4 receptor 6W25 DP2 receptor 6D27
TM1 24 Q 1.49x49 MC4 receptor 6W25 - -
TM1 25 S 1.50x50 MC4 receptor 6W25 - -
TM1 26 S 1.51x51 MC4 receptor 6W25 κ receptor 4DJH
TM1 27 L 1.52x52 MC4 receptor 6W25 MC4 receptor 6W25
TM1 28 I 1.53x53 MC4 receptor 6W25 DP2 receptor 6D27
TM1 29 V 1.54x54 MC4 receptor 6W25 CCR2 5T1A
TM1 30 A 1.55x55 MC4 receptor 6W25 5-HT1B receptor 4IAQ
TM1 31 V 1.56x56 MC4 receptor 6W25 GPR52 6LI1
TM1 32 L 1.57x57 MC4 receptor 6W25 CCR5 4MBS
TM1 33 G 1.58x58 MC4 receptor 6W25 DP2 receptor 6D27
TM1 34 R 1.59x59 MC4 receptor 6W25 κ receptor 4DJH
TM1 35 E 1.60x60 MC4 receptor 6W25 5-HT2C receptor 6BQH
TM1 36 W 1.61x61 EP3 receptor 6M9T - -
TM1 37 L 1.62x62 EP3 receptor 6M9T - -
ICL1 38 Q 12.48x48 - - - -
ICL1 39 V 12.49x49 κ receptor 4DJH - -
ICL1 40 R 12.50x50 κ receptor 4DJH - -
ICL1 41 R 12.51x51 - - - -
TM2 42 L 2.36x36 EP3 receptor 6M9T - -
TM2 43 M 2.37x37 MC4 receptor 6W25 - -
TM2 44 P 2.38x38 MC4 receptor 6W25 MC4 receptor 6W25
TM2 45 V 2.39x39 MC4 receptor 6W25 DP2 receptor 6D27
TM2 46 D 2.40x40 MC4 receptor 6W25 CXCR2 6LFL
TM2 47 M 2.41x41 MC4 receptor 6W25 CCR9 5LWE
TM2 48 I 2.42x42 MC4 receptor 6W25 Rhodopsin 1U19
TM2 49 L 2.43x43 MC4 receptor 6W25 CXCR2 6LFL
TM2 50 I 2.44x44 MC4 receptor 6W25 CysLT1 receptor 6RZ4
TM2 51 S 2.45x45 MC4 receptor 6W25 MC4 receptor 6W25
TM2 52 L 2.46x46 MC4 receptor 6W25 MC4 receptor 6W25
TM2 53 G 2.47x47 MC4 receptor 6W25 FFA1 receptor 5TZY
TM2 54 I 2.48x48 MC4 receptor 6W25 5-HT2C receptor 6BQH
TM2 55 S 2.49x49 MC4 receptor 6W25 DP2 receptor 6D27
TM2 56 R 2.50x50 MC4 receptor 6W25 - -
TM2 57 F 2.51x51 MC4 receptor 6W25 Rhodopsin 6I9K
TM2 58 C 2.52x52 MC4 receptor 6W25 AT1 receptor 4ZUD
TM2 59 L 2.53x53 MC4 receptor 6W25 CCK1 receptor 7MBX
TM2 60 Q 2.54x54 MC4 receptor 6W25 EP3 receptor 6AK3
TM2 61 W 2.55x55 MC4 receptor 6W25 - -
TM2 62 A 2.56x56 MC4 receptor 6W25 S1P1 receptor 3V2Y
TM2 63 S 2.57x57 MC4 receptor 6W25 EP4 receptor 5YWY
TM2 64 M 2.58x58 MC4 receptor 6W25 Rhodopsin 6I9K
TM2 65 L 2.59x59 MC4 receptor 6W25 MT2 receptor 6ME7
TM2 66 N 2.60x60 MC4 receptor 6W25 H1 receptor 3RZE
TM2 67 N 2.61x61 MC4 receptor 6W25 NK1 receptor 6HLP
TM2 68 F 2.62x62 MC4 receptor 6W25 P2Y1 receptor 4XNW
TM2 69 C 2.63x63 MC4 receptor 6W25 β2-adrenoceptor 4QKX
TM2 70 S 2.64x64 MC4 receptor 6W25 A2A receptor 4UHR
TM2 71 Y 2.65x65 MC4 receptor 6W25 apelin receptor 5VBL
TM2 72 F 2.66x66 MC4 receptor 6W25 Rhodopsin 6I9K
ECL1 73 N - - - - -
ECL1 74 L - - - - -
ECL1 75 N - - - - -
ECL1 76 Y - - - - -
TM3 77 V 3.24x24 MC4 receptor 6W25 5-HT1B receptor 4IAQ
TM3 78 L 3.25x25 MC4 receptor 6W25 - -
TM3 79 C 3.26x26 MC4 receptor 6W25 - -
TM3 80 N 3.27x27 MC4 receptor 6W25 - -
TM3 81 L 3.28x28 MC4 receptor 6W25 CCR5 4MBS
TM3 82 T 3.29x29 MC4 receptor 6W25 CCR5 4MBS
TM3 83 I 3.30x30 MC4 receptor 6W25 FPR2/ALX 6OMM
TM3 84 T 3.31x31 MC4 receptor 6W25 EP3 receptor 6AK3
TM3 85 W 3.32x32 MC4 receptor 6W25 - -
TM3 86 E 3.33x33 MC4 receptor 6W25 CXCR2 6LFL
TM3 87 F 3.34x34 MC4 receptor 6W25 AT1 receptor 4ZUD
TM3 88 F 3.35x35 MC4 receptor 6W25 Rhodopsin 6I9K
TM3 89 N 3.36x36 MC4 receptor 6W25 - -
TM3 90 I 3.37x37 MC4 receptor 6W25 MT2 receptor 6ME7
TM3 91 L 3.38x38 MC4 receptor 6W25 - -
TM3 92 T 3.39x39 MC4 receptor 6W25 ETB receptor 5X93
TM3 93 F 3.40x40 MC4 receptor 6W25 - -
TM3 94 W 3.41x41 MC4 receptor 6W25 GPR52 6LI1
TM3 95 L 3.42x42 MC4 receptor 6W25 DP2 receptor 6D27
TM3 96 N 3.43x43 MC4 receptor 6W25 - -
TM3 97 S 3.44x44 MC4 receptor 6W25 DP2 receptor 6D27
TM3 98 L 3.45x45 MC4 receptor 6W25 CCR5 4MBS
TM3 99 L 3.46x46 MC4 receptor 6W25 CCR5 4MBS
TM3 100 T 3.47x47 MC4 receptor 6W25 Rhodopsin 6I9K
TM3 101 V 3.48x48 MC4 receptor 6W25 MC4 receptor 6W25
TM3 102 F 3.49x49 MC4 receptor 6W25 CysLT1 receptor 6RZ4
TM3 103 Y 3.50x50 MC4 receptor 6W25 - -
TM3 104 C 3.51x51 MC4 receptor 6W25 DP2 receptor 6D27
TM3 105 I 3.52x52 MC4 receptor 6W25 κ receptor 4DJH
TM3 106 K 3.53x53 MC4 receptor 6W25 P2Y12 receptor 4NTJ
TM3 107 V 3.54x54 MC4 receptor 6W25 DP2 receptor 6D27
TM3 108 S 3.55x55 MC4 receptor 6W25 D1 receptor 7JVQ
TM3 109 S 3.56x56 MC4 receptor 6W25 β1-adrenoceptor 7BVQ
ICL2 110 F - - - - -
ICL2 111 T - - - - -
ICL2 112 H 34.50x50 DP2 receptor 6D27 - -
ICL2 113 H 34.51x51 DP2 receptor 6D27 EP3 receptor 6AK3
ICL2 114 I 34.52x52 DP2 receptor 6D27 - -
ICL2 115 F 34.53x53 DP2 receptor 6D27 - -
ICL2 116 L 34.54x54 DP2 receptor 6D27 κ receptor 6B73
ICL2 117 W 34.55x55 DP2 receptor 6D27 - -
ICL2 118 L 34.56x56 DP2 receptor 6D27 GPR52 6LI1
ICL2 119 R 34.57x57 - - - -
TM4 120 W 4.38x38 MC4 receptor 6W25 - -
TM4 121 R 4.39x39 MC4 receptor 6W25 CXCR2 6LFL
TM4 122 I 4.40x40 MC4 receptor 6W25 - -
TM4 123 L 4.41x41 MC4 receptor 6W25 CXCR2 6LFL
TM4 124 R 4.42x42 MC4 receptor 6W25 - -
TM4 125 L 4.43x43 MC4 receptor 6W25 Rhodopsin 6I9K
TM4 126 F 4.44x44 MC4 receptor 6W25 CXCR2 6LFL
TM4 127 P 4.45x45 MC4 receptor 6W25 V2 receptor 7KH0
TM4 128 W 4.46x46 MC4 receptor 6W25 - -
TM4 129 I 4.47x47 MC4 receptor 6W25 GPR52 6LI1
TM4 130 L 4.48x48 MC4 receptor 6W25 GPR52 6LI1
TM4 131 L 4.49x49 MC4 receptor 6W25 DP2 receptor 6D27
TM4 132 G 4.50x50 MC4 receptor 6W25 - -
TM4 133 S 4.51x51 MC4 receptor 6W25 - -
TM4 134 L 4.52x52 MC4 receptor 6W25 DP2 receptor 6D27
TM4 135 M 4.53x53 MC4 receptor 6W25 P2Y12 receptor 4NTJ
TM4 136 I 4.54x54 MC4 receptor 6W25 5-HT2C receptor 6BQH
TM4 137 T 4.55x55 MC4 receptor 6W25 CCK1 receptor 7MBX
TM4 138 C 4.56x56 MC4 receptor 6W25 Rhodopsin 1U19
TM4 139 V 4.57x57 MC4 receptor 6W25 PAR1 3VW7
TM4 140 T 4.58x58 MC4 receptor 6W25 - -
TM4 141 I 4.59x59 MC4 receptor 6W25 CXCR4 3ODU
TM4 142 I 4.60x60 MC4 receptor 6W25 P2Y1 receptor 4XNW
TM4 143 P 4.61x61 MC4 receptor 6W25 - -
TM4 144 S 4.62x62 MC4 receptor 6W25 - -
TM4 145 A 4.63x63 MC4 receptor 6W25 BLT1 receptor 5X33
TM4 146 I 4.64x64 MC4 receptor 6W25 5-HT2C receptor 6BQH
ECL2 147 G - - - - -
ECL2 148 N - PAR1 3VW7 - -
ECL2 149 Y - PAR1 3VW7 - -
ECL2 150 I - PAR1 3VW7 PAR1 3VW7
ECL2 151 Q - PAR1 3VW7 PAR1 3VW7
ECL2 152 I - PAR1 3VW7 - -
ECL2 153 Q - PAR1 3VW7 - -
ECL2 154 L - PAR1 3VW7 - -
ECL2 155 L - PAR1 3VW7 PAR1 3VW7
ECL2 156 T - PAR1 3VW7 - -
ECL2 157 M - PAR1 3VW7 - -
ECL2 158 E - PAR1 3VW7 - -
ECL2 159 H - PAR1 3VW7 - -
ECL2 160 L - PAR1 3VW7 - -
ECL2 161 P - PAR1 3VW7 - -
ECL2 162 R - PAR1 3VW7 - -
ECL2 163 N - PAR1 3VW7 - -
ECL2 164 S - PAR1 3VW7 - -
ECL2 165 T - PAR1 3VW7 - -
ECL2 166 V - PAR1 3VW7 - -
ECL2 167 T - PAR1 3VW7 PAR1 3VW7
ECL2 168 D - PAR1 3VW7 - -
ECL2 169 K - - - - -
TM5 170 L 5.32x32 DP2 receptor 6D27 PAR2 5NDD
TM5 171 E 5.33x33 DP2 receptor 6D27 BLT1 receptor 7K15
TM5 172 N 5.34x34 DP2 receptor 6D27 CXCR2 6LFL
TM5 173 F 5.35x35 DP2 receptor 6D27 - -
TM5 174 H 5.36x36 MC4 receptor 6W25 5-HT1B receptor 4IAQ
TM5 175 Q 5.37x37 MC4 receptor 6W25 CCK1 receptor 7MBX
TM5 176 Y 5.38x38 MC4 receptor 6W25 PAR1 3VW7
TM5 177 Q 5.39x39 MC4 receptor 6W25 CCR5 4MBS
TM5 178 F 5.40x40 MC4 receptor 6W25 GPR52 6LI1
TM5 179 Q 5.41x41 MC4 receptor 6W25 NTS1 receptor 6OSA
TM5 180 A 5.42x42 MC4 receptor 6W25 MT2 receptor 6ME7
TM5 181 H 5.43x43 MC4 receptor 6W25 CXCR4 3ODU
TM5 182 T 5.44x44 MC4 receptor 6W25 P2Y1 receptor 4XNW
TM5 183 V 5.45x45 MC4 receptor 6W25 GPR52 6LI1
TM5 184 A 5.46x46 MC4 receptor 6W25 P2Y1 receptor 4XNW
TM5 185 L 5.47x47 MC4 receptor 6W25 GPR52 6LI1
TM5 186 V 5.48x48 MC4 receptor 6W25 κ receptor 4DJH
TM5 187 I 5.49x49 MC4 receptor 6W25 κ receptor 4DJH
TM5 188 P 5.50x50 MC4 receptor 6W25 GPR52 6LI1
TM5 189 F 5.51x51 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM5 190 I 5.52x52 MC4 receptor 6W25 CXCR4 3ODU
TM5 191 L 5.53x53 MC4 receptor 6W25 MC4 receptor 6W25
TM5 192 F 5.54x54 MC4 receptor 6W25 - -
TM5 193 L 5.55x55 MC4 receptor 6W25 CXCR2 6LFL
TM5 194 A 5.56x56 MC4 receptor 6W25 5-HT1B receptor 4IAQ
TM5 195 S 5.57x57 MC4 receptor 6W25 DP2 receptor 6D27
TM5 196 T 5.58x58 MC4 receptor 6W25 GPR52 6LI1
TM5 197 I 5.59x59 MC4 receptor 6W25 D2 receptor 7JVR
TM5 198 F 5.60x60 MC4 receptor 6W25 GPR52 6LI1
TM5 199 L 5.61x61 MC4 receptor 6W25 EP2 receptor 7CX2
TM5 200 M 5.62x62 MC4 receptor 6W25 - -
TM5 201 A 5.63x63 MC4 receptor 6W25 TP receptor 6IIV
TM5 202 S 5.64x64 MC4 receptor 6W25 5-HT2A receptor 6A94
TM5 203 L 5.65x65 Rhodopsin 6I9K DP2 receptor 6D27
TM5 204 T 5.66x66 Rhodopsin 6I9K β3-adrenoceptor 7DH5
TM5 205 K 5.67x67 Rhodopsin 6I9K CXCR2 6LFL
TM5 206 Q 5.68x68 Rhodopsin 6I9K GPR52 6LI2
TM5 207 I 5.69x69 Rhodopsin 6I9K 5-HT1B receptor 4IAR
TM5 208 Q 5.70x70 Rhodopsin 6I9K β2-adrenoceptor 3SN6
TM5 209 H 5.71x71 Rhodopsin 6I9K - -
TM5 210 H 5.72x72 Rhodopsin 6I9K - -
ICL3 211 S - - - - -
ICL3 212 T - - - - -
ICL3 213 G - - - - -
ICL3 214 H - - - - -
ICL3 215 C - - - - -
ICL3 216 N - - - - -
TM6 217 P 6.29x29 MC4 receptor 6W25 P2Y1 receptor 4XNW
TM6 218 S 6.30x30 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM6 219 M 6.31x31 MC4 receptor 6W25 MC4 receptor 6W25
TM6 220 K 6.32x32 MC4 receptor 6W25 MC4 receptor 6W25
TM6 221 A 6.33x33 MC4 receptor 6W25 CXCR2 6LFO
TM6 222 R 6.34x34 MC4 receptor 6W25 - -
TM6 223 F 6.35x35 MC4 receptor 6W25 α2A-adrenoceptor 6KUX
TM6 224 T 6.36x36 MC4 receptor 6W25 MC4 receptor 6W25
TM6 225 A 6.37x37 MC4 receptor 6W25 Rhodopsin 6I9K
TM6 226 L 6.38x38 MC4 receptor 6W25 κ receptor 4DJH
TM6 227 R 6.39x39 MC4 receptor 6W25 GPR52 6LI1
TM6 228 S 6.40x40 MC4 receptor 6W25 - -
TM6 229 L 6.41x41 MC4 receptor 6W25 5-HT1B receptor 4IAQ
TM6 230 A 6.42x42 MC4 receptor 6W25 DP2 receptor 6D27
TM6 231 V 6.43x43 MC4 receptor 6W25 MC4 receptor 6W25
TM6 232 L 6.44x44 MC4 receptor 6W25 CB1 receptor 5TGZ
TM6 233 F 6.45x45 MC4 receptor 6W25 Rhodopsin 6I9K
TM6 234 I 6.46x46 MC4 receptor 6W25 MT2 receptor 6ME7
TM6 235 V 6.47x47 MC4 receptor 6W25 - -
TM6 236 F 6.48x48 MC4 receptor 6W25 MT2 receptor 6ME7
TM6 237 T 6.49x49 MC4 receptor 6W25 κ receptor 4DJH
TM6 238 S 6.50x50 MC4 receptor 6W25 - -
TM6 239 Y 6.51x51 MC4 receptor 6W25 GPR52 6LI1
TM6 240 F 6.52x52 MC4 receptor 6W25 MC4 receptor 6W25
TM6 241 L 6.53x53 MC4 receptor 6W25 MC4 receptor 6W25
TM6 242 T 6.54x54 MC4 receptor 6W25 5-HT2C receptor 6BQH
TM6 243 I 6.55x55 MC4 receptor 6W25 κ receptor 4DJH
TM6 244 L 6.56x56 MC4 receptor 6W25 GPR52 6LI1
TM6 245 I 6.57x57 MC4 receptor 6W25 CXCR4 3ODU
TM6 246 T 6.58x58 MC4 receptor 6W25 α2A-adrenoceptor 6KUX
TM6 247 I 6.59x59 MC4 receptor 6W25 MC4 receptor 6W25
TM6 248 I 6.60x60 MC4 receptor 6W25 MT2 receptor 6ME7
TM6 249 G 6.61x61 MC4 receptor 6W25 κ receptor 6B73
ECL3 250 T - - - - -
ECL3 251 L - - - - -
ECL3 252 F - - - - -
ECL3 253 D - - - - -
TM7 254 K 7.31x31 DP2 receptor 6D27 CB1 receptor 5TGZ
TM7 255 R 7.32x32 DP2 receptor 6D27 DP2 receptor 6D27
TM7 256 C 7.33x33 MC4 receptor 6W25 CCR9 5LWE
TM7 257 W 7.34x34 MC4 receptor 6W25 μ receptor 5C1M
TM7 258 L 7.35x35 MC4 receptor 6W25 PAR1 3VW7
TM7 259 W 7.36x36 MC4 receptor 6W25 Rhodopsin 6I9K
TM7 260 V 7.37x37 MC4 receptor 6W25 DP2 receptor 6D27
TM7 261 W 7.38x38 MC4 receptor 6W25 - -
TM7 262 E 7.39x39 MC4 receptor 6W25 - -
TM7 263 A 7.40x40 MC4 receptor 6W25 - -
TM7 264 F 7.41x41 MC4 receptor 6W25 ghrelin receptor 6KO5
TM7 265 V 7.42x42 MC4 receptor 6W25 LPA6 receptor 5XSZ
TM7 266 Y 7.43x43 MC4 receptor 6W25 - -
TM7 267 A 7.44x44 - - - -
TM7 268 F 7.45x45 MC4 receptor 6W25 - -
TM7 269 I 7.46x46 MC4 receptor 6W25 - -
TM7 270 L 7.47x47 MC4 receptor 6W25 5-HT1B receptor 4IAQ
TM7 271 M 7.48x48 MC4 receptor 6W25 LPA1 receptor 4Z35
TM7 272 H 7.49x49 MC4 receptor 6W25 - -
TM7 273 S 7.50x50 MC4 receptor 6W25 - -
TM7 274 T 7.51x51 MC4 receptor 6W25 - -
TM7 275 S 7.52x52 MC4 receptor 6W25 - -
TM7 276 L 7.53x53 MC4 receptor 6W25 ETB receptor 5X93
TM7 277 M 7.54x54 MC4 receptor 6W25 OT receptor 6TPK
TM7 278 L 7.55x55 MC4 receptor 6W25 MC4 receptor 6W25
TM7 279 S 7.56x56 MC4 receptor 6W25 GPR52 6LI1
H8 280 S 8.47x47 MC4 receptor 6W25 MC4 receptor 6W25
H8 281 P 8.48x48 MC4 receptor 6W25 DP2 receptor 6D27
H8 282 T 8.49x49 MC4 receptor 6W25 GPR52 6LI1
H8 283 L 8.50x50 MC4 receptor 6W25 MC4 receptor 6W25
H8 284 K 8.51x51 MC4 receptor 6W25 κ receptor 4DJH
H8 285 R 8.52x52 MC4 receptor 6W25 DP2 receptor 6D27
H8 286 I 8.53x53 MC4 receptor 6W25 NTS1 receptor 6OSA
H8 287 L 8.54x54 MC4 receptor 6W25 GPR52 6LI1
H8 288 K 8.55x55 MC4 receptor 6W25 MC4 receptor 6W25
H8 289 G 8.56x56 MC4 receptor 6W25 β1-adrenoceptor 7BVQ
H8 290 K 8.57x57 MC4 receptor 6W25 EP4 receptor 5YWY
H8 291 C 8.58x58 MC4 receptor 6W25 κ receptor 4DJH