TAS2R41 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-04-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

PAR1 (sequence similarity: 20%) PDB: 3VW7

TEMPLATES

3VW7 (PAR1)
6M9T (EP3 receptor)
3RZE (H1 receptor)
5ZKQ (PAF receptor)
7JVR (D2 receptor)
7CMV (D3 receptor)
3PBL (D3 receptor)
4DJH (κ receptor)
5VBL (apelin receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 69.8 13.8 16.4
Side-chains 11.1 54.8 34.1

Number of backbone templates: 9
Number of rotamer templates: 51

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 1 M - PAR1 3VW7 PAR1 3VW7
N-term 2 Q - PAR1 3VW7 PAR1 3VW7
N-term 3 A - PAR1 3VW7 PAR1 3VW7
N-term 4 A - PAR1 3VW7 PAR1 3VW7
N-term 5 L - PAR1 3VW7 PAR1 3VW7
TM1 6 T 1.32x32 PAR1 3VW7 PAR1 3VW7
TM1 7 A 1.33x33 PAR1 3VW7 apelin receptor 5VBL
TM1 8 F 1.34x34 PAR1 3VW7 PAR1 3VW7
TM1 9 F 1.35x35 PAR1 3VW7 CysLT2 receptor 6RZ6
TM1 10 V 1.36x36 PAR1 3VW7 H1 receptor 7DFL
TM1 11 L 1.37x37 PAR1 3VW7 P2Y12 receptor 4NTJ
TM1 12 L 1.38x38 PAR1 3VW7 5-HT2B receptor 5TVN
TM1 13 F 1.39x39 PAR1 3VW7 LPA6 receptor 5XSZ
TM1 14 S 1.40x40 PAR1 3VW7 LPA6 receptor 5XSZ
TM1 15 L 1.41x41 PAR1 3VW7 5-HT2B receptor 5TVN
TM1 16 L 1.42x42 PAR1 3VW7 MC4 receptor 6W25
TM1 17 S 1.43x43 PAR1 3VW7 CysLT1 receptor 6RZ4
TM1 18 L 1.44x44 PAR1 3VW7 H1 receptor 3RZE
TM1 19 L 1.45x45 PAR1 3VW7 PAF receptor 5ZKQ
TM1 20 G 1.46x46 PAR1 3VW7 LPA6 receptor 5XSZ
TM1 21 I 1.47x47 PAR1 3VW7 5-HT2B receptor 5TVN
TM1 22 A 1.48x48 PAR1 3VW7 GPR52 6LI1
TM1 23 A 1.49x49 PAR1 3VW7 PAF receptor 5ZKQ
TM1 24 N 1.50x50 PAR1 3VW7 PAR1 3VW7
TM1 25 G 1.51x51 PAR1 3VW7 PAR2 5NDD
TM1 26 F 1.52x52 PAR1 3VW7 CysLT1 receptor 6RZ4
TM1 27 I 1.53x53 PAR1 3VW7 DP2 receptor 6D27
TM1 28 V 1.54x54 PAR1 3VW7 succinate receptor 6RNK
TM1 29 L 1.55x55 PAR1 3VW7 5-HT2B receptor 5TVN
TM1 30 V 1.56x56 PAR1 3VW7 PAR1 3VW7
TM1 31 L 1.57x57 PAR1 3VW7 CysLT1 receptor 6RZ4
TM1 32 G 1.58x58 PAR1 3VW7 CXCR4 3ODU
TM1 33 R 1.59x59 PAR1 3VW7 D2 receptor 7JVR
TM1 34 E 1.60x60 PAR1 3VW7 C5a1 receptor 6C1Q
TM1 35 W 1.61x61 EP3 receptor 6M9T - -
TM1 36 L 1.62x62 EP3 receptor 6M9T - -
ICL1 37 R 12.48x48 - - - -
ICL1 38 Y 12.49x49 H1 receptor 3RZE - -
ICL1 39 G 12.50x50 H1 receptor 3RZE CXCR2 6LFL
ICL1 40 R 12.51x51 - - - -
TM2 41 L 2.36x36 PAF receptor 5ZKQ - -
TM2 42 L 2.37x37 PAR1 3VW7 - -
TM2 43 P 2.38x38 PAR1 3VW7 PAR1 3VW7
TM2 44 L 2.39x39 PAR1 3VW7 Rhodopsin 5W0P
TM2 45 D 2.40x40 PAR1 3VW7 apelin receptor 5VBL
TM2 46 M 2.41x41 PAR1 3VW7 CCR9 5LWE
TM2 47 I 2.42x42 PAR1 3VW7 Rhodopsin 5W0P
TM2 48 L 2.43x43 PAR1 3VW7 5-HT2B receptor 5TVN
TM2 49 I 2.44x44 PAR1 3VW7 CysLT1 receptor 6RZ4
TM2 50 S 2.45x45 PAR1 3VW7 5-HT2B receptor 5TVN
TM2 51 L 2.46x46 PAR1 3VW7 PAR1 3VW7
TM2 52 G 2.47x47 PAR1 3VW7 FFA1 receptor 5TZY
TM2 53 A 2.48x48 PAR1 3VW7 LPA1 receptor 4Z35
TM2 54 S 2.49x49 PAR1 3VW7 LPA6 receptor 5XSZ
TM2 55 R 2.50x50 PAR1 3VW7 - -
TM2 56 F 2.51x51 PAR1 3VW7 P2Y1 receptor 4XNW
TM2 57 C 2.52x52 PAR1 3VW7 AT1 receptor 4ZUD
TM2 58 L 2.53x53 PAR1 3VW7 FFA1 receptor 5TZY
TM2 59 Q 2.54x54 PAR1 3VW7 EP3 receptor 6AK3
TM2 60 L 2.55x55 PAR1 3VW7 LPA6 receptor 5XSZ
TM2 61 V 2.56x56 PAR1 3VW7 PAR1 3VW7
TM2 62 G 2.57x57 PAR1 3VW7 TP receptor 6IIV
TM2 63 T 2.58x58 PAR1 3VW7 TP receptor 6IIV
TM2 64 V 2.59x59 PAR1 3VW7 GPR52 6LI1
TM2 65 H 2.60x60 PAR1 3VW7 - -
TM2 66 N 2.61x61 PAR1 3VW7 NK1 receptor 6HLP
TM2 67 F 2.62x62 PAR1 3VW7 LPA6 receptor 5XSZ
TM2 68 Y 2.63x63 PAR1 3VW7 PAR1 3VW7
TM2 69 Y 2.64x64 PAR1 3VW7 PAR1 3VW7
TM2 70 S 2.65x65 PAR1 3VW7 AT2 receptor 5UNG
TM2 71 A 2.66x66 PAR1 3VW7 TP receptor 6IIV
TM2 72 Q 2.67x67 D2 receptor 7JVR PAF receptor 5ZKQ
ECL1 73 K - - - - -
ECL1 74 V - D3 receptor 7CMV D3 receptor 7CMV
ECL1 75 E - D3 receptor 7CMV - -
ECL1 76 Y - D3 receptor 7CMV - -
ECL1 77 S - - - - -
TM3 78 G 3.21x21 PAR1 3VW7 PAR1 3VW7
TM3 79 G 3.22x22 PAR1 3VW7 D1 receptor 7JVQ
TM3 80 L 3.23x23 PAR1 3VW7 CysLT2 receptor 6RZ6
TM3 81 G 3.24x24 PAR1 3VW7 BLT1 receptor 5X33
TM3 82 R 3.25x25 PAR1 3VW7 - -
TM3 83 Q 3.26x26 PAR1 3VW7 P2Y12 receptor 4NTJ
TM3 84 F 3.27x27 PAR1 3VW7 PAR1 3VW7
TM3 85 F 3.28x28 PAR1 3VW7 GPR52 6LI1
TM3 86 H 3.29x29 PAR1 3VW7 CXCR4 3ODU
TM3 87 L 3.30x30 PAR1 3VW7 CXCR2 6LFL
TM3 88 H 3.31x31 PAR1 3VW7 - -
TM3 89 W 3.32x32 PAR1 3VW7 - -
TM3 90 H 3.33x33 PAR1 3VW7 P2Y1 receptor 4XNW
TM3 91 F 3.34x34 PAR1 3VW7 P2Y12 receptor 4NTJ
TM3 92 L 3.35x35 PAR1 3VW7 GPR52 6LI1
TM3 93 N 3.36x36 PAR1 3VW7 - -
TM3 94 S 3.37x37 PAR1 3VW7 GPR52 6LI1
TM3 95 A 3.38x38 PAR1 3VW7 PAR1 3VW7
TM3 96 T 3.39x39 PAR1 3VW7 ETB receptor 5X93
TM3 97 F 3.40x40 PAR1 3VW7 - -
TM3 98 W 3.41x41 PAR1 3VW7 5-HT2B receptor 5TVN
TM3 99 F 3.42x42 PAR1 3VW7 LPA6 receptor 5XSZ
TM3 100 C 3.43x43 PAR1 3VW7 - -
TM3 101 S 3.44x44 PAR1 3VW7 DP2 receptor 6D27
TM3 102 W 3.45x45 PAR1 3VW7 - -
TM3 103 L 3.46x46 PAR1 3VW7 PAR2 5NDD
TM3 104 S 3.47x47 PAR1 3VW7 PAR1 3VW7
TM3 105 V 3.48x48 PAR1 3VW7 LPA6 receptor 5XSZ
TM3 106 L 3.49x49 PAR1 3VW7 - -
TM3 107 F 3.50x50 PAR1 3VW7 - -
TM3 108 C 3.51x51 PAR1 3VW7 CysLT1 receptor 6RZ4
TM3 109 V 3.52x52 PAR1 3VW7 5-HT2A receptor 6A94
TM3 110 K 3.53x53 PAR1 3VW7 P2Y12 receptor 4NTJ
TM3 111 I 3.54x54 PAR1 3VW7 LPA6 receptor 5XSZ
TM3 112 A 3.55x55 PAR1 3VW7 FFA1 receptor 5TZY
TM3 113 N 3.56x56 PAR1 3VW7 PAR2 5NDD
ICL2 114 I - - - - -
ICL2 115 T - - - - -
ICL2 116 H 34.50x50 D3 receptor 3PBL - -
ICL2 117 S 34.51x51 D3 receptor 3PBL - -
ICL2 118 T 34.52x52 D3 receptor 3PBL M2 receptor 5YC8
ICL2 119 F 34.53x53 D3 receptor 3PBL - -
ICL2 120 L 34.54x54 D3 receptor 3PBL P2Y1 receptor 4XNW
ICL2 121 W 34.55x55 D3 receptor 3PBL - -
ICL2 122 L 34.56x56 D3 receptor 3PBL LPA6 receptor 5XSZ
ICL2 123 K 34.57x57 - - - -
TM4 124 W 4.38x38 PAR1 3VW7 - -
TM4 125 R 4.39x39 PAR1 3VW7 5-HT2B receptor 5TVN
TM4 126 F 4.40x40 PAR1 3VW7 S1P1 receptor 3V2Y
TM4 127 P 4.41x41 PAR1 3VW7 - -
TM4 128 G 4.42x42 PAR1 3VW7 PAF receptor 5ZKQ
TM4 129 W 4.43x43 PAR1 3VW7 CysLT2 receptor 6RZ6
TM4 130 V 4.44x44 PAR1 3VW7 D2 receptor 7JVR
TM4 131 P 4.45x45 PAR1 3VW7 - -
TM4 132 W 4.46x46 PAR1 3VW7 - -
TM4 133 L 4.47x47 PAR1 3VW7 PAR1 3VW7
TM4 134 L 4.48x48 PAR1 3VW7 P2Y1 receptor 4XNW
TM4 135 L 4.49x49 PAR1 3VW7 apelin receptor 5VBL
TM4 136 G 4.50x50 PAR1 3VW7 - -
TM4 137 S 4.51x51 PAR1 3VW7 - -
TM4 138 V 4.52x52 PAR1 3VW7 CCR2 5T1A
TM4 139 L 4.53x53 PAR1 3VW7 - -
TM4 140 I 4.54x54 PAR1 3VW7 PAR1 3VW7
TM4 141 S 4.55x55 PAR1 3VW7 LPA6 receptor 5XSZ
TM4 142 F 4.56x56 PAR1 3VW7 EP4 receptor 5YWY
TM4 143 I 4.57x57 κ receptor 4DJH P2Y1 receptor 4XNW
TM4 144 I 4.58x58 κ receptor 4DJH κ receptor 4DJH
TM4 145 T 4.59x59 κ receptor 4DJH BLT1 receptor 5X33
TM4 146 L 4.60x60 PAR1 3VW7 - -
TM4 147 L 4.61x61 PAR1 3VW7 PAR1 3VW7
TM4 148 F 4.62x62 PAR1 3VW7 LPA6 receptor 5XSZ
TM4 149 F 4.63x63 PAR1 3VW7 GPR52 6LI1
ECL2 150 W - - - - -
ECL2 151 V - - - - -
ECL2 152 N - - - - -
ECL2 153 Y - - - - -
ECL2 154 P - - - - -
ECL2 155 V - - - - -
ECL2 156 Y - - - - -
ECL2 157 Q - - - - -
ECL2 158 E - - - - -
ECL2 159 F - - - - -
ECL2 160 L - - - - -
ECL2 161 I - - - - -
ECL2 162 R - - - - -
ECL2 163 K - - - - -
ECL2 164 F - - - - -
ECL2 165 S - - - - -
ECL2 166 G - - - - -
ECL2 167 N - - - - -
ECL2 168 M - - - - -
ECL2 169 T - - - - -
ECL2 170 Y - - - - -
ECL2 171 K - - - - -
ECL2 172 W - - - - -
ECL2 173 N - - - - -
TM5 174 T 5.32x32 PAR1 3VW7 - -
TM5 175 R 5.33x33 PAR1 3VW7 - -
TM5 176 I 5.34x34 PAR1 3VW7 NK1 receptor 6HLP
TM5 177 E 5.35x35 PAR1 3VW7 - -
TM5 178 T 5.36x36 PAR1 3VW7 - -
TM5 179 Y 5.37x37 PAR1 3VW7 PAR1 3VW7
TM5 180 Y 5.38x38 PAR1 3VW7 PAR1 3VW7
TM5 181 F 5.39x39 PAR1 3VW7 PAR1 3VW7
TM5 182 P 5.40x40 PAR1 3VW7 - -
TM5 183 S 5.41x41 PAR1 3VW7 EP3 receptor 6AK3
TM5 184 L 5.42x42 PAR1 3VW7 TP receptor 6IIV
TM5 185 K 5.43x43 PAR1 3VW7 AT1 receptor 4ZUD
TM5 186 L 5.44x44 PAR1 3VW7 CysLT2 receptor 6RZ6
TM5 187 V 5.45x45 PAR1 3VW7 PAR1 3VW7
TM5 188 I 5.46x46 PAR1 3VW7 P2Y12 receptor 4NTJ
TM5 189 W 5.47x47 PAR1 3VW7 - -
TM5 190 S 5.48x48 PAR1 3VW7 CB1 receptor 5TGZ
TM5 191 I 5.49x49 PAR1 3VW7 LPA6 receptor 5XSZ
TM5 192 P 5.50x50 PAR1 3VW7 PAR1 3VW7
TM5 193 F 5.51x51 PAR1 3VW7 CysLT2 receptor 6RZ6
TM5 194 S 5.52x52 PAR1 3VW7 succinate receptor 6RNK
TM5 195 V 5.53x53 PAR1 3VW7 succinate receptor 6RNK
TM5 196 F 5.54x54 PAR1 3VW7 - -
TM5 197 L 5.55x55 PAR1 3VW7 P2Y1 receptor 4XNW
TM5 198 V 5.56x56 PAR1 3VW7 PAR1 3VW7
TM5 199 S 5.57x57 PAR1 3VW7 AT1 receptor 4ZUD
TM5 200 I 5.58x58 PAR1 3VW7 - -
TM5 201 M 5.59x59 PAR1 3VW7 CB1 receptor 5TGZ
TM5 202 L 5.60x60 PAR1 3VW7 PAR2 5NDD
TM5 203 L 5.61x61 PAR1 3VW7 Rhodopsin 5W0P
TM5 204 I 5.62x62 PAR1 3VW7 PAR1 3VW7
TM5 205 N 5.63x63 PAR1 3VW7 NTS1 receptor 6OSA
TM5 206 S 5.64x64 PAR1 3VW7 5-HT2A receptor 6A94
TM5 207 L 5.65x65 PAR1 3VW7 PAR1 3VW7
TM5 208 R 5.66x66 PAR1 3VW7 H1 receptor 7DFL
TM5 209 R 5.67x67 PAR1 3VW7 - -
TM5 210 H 5.68x68 D2 receptor 7JVR CB1 receptor 5TGZ
TM5 211 T 5.69x69 D2 receptor 7JVR α2A-adrenoceptor 6KUX
TM5 212 Q 5.70x70 D2 receptor 7JVR β2-adrenoceptor 3SN6
TM5 213 R 5.71x71 D2 receptor 7JVR D2 receptor 7JVR
TM5 214 M 5.72x72 D2 receptor 7JVR CB1 receptor 6N4B
ICL3 215 Q - - - - -
ICL3 216 H - - - - -
ICL3 217 N - - - - -
ICL3 218 G - - - - -
ICL3 219 H - - - - -
ICL3 220 S - - - - -
ICL3 221 L - - - - -
ICL3 222 Q - - - - -
ICL3 223 D - - - - -
TM6 224 P 6.29x29 PAR1 3VW7 P2Y1 receptor 4XNW
TM6 225 S 6.30x30 PAR1 3VW7 CysLT2 receptor 6RZ6
TM6 226 T 6.31x31 PAR1 3VW7 D1 receptor 7JVQ
TM6 227 Q 6.32x32 PAR1 3VW7 ghrelin receptor 6KO5
TM6 228 A 6.33x33 PAR1 3VW7 5-HT2B receptor 5TVN
TM6 229 H 6.34x34 PAR1 3VW7 - -
TM6 230 T 6.35x35 PAR1 3VW7 - -
TM6 231 R 6.36x36 PAR1 3VW7 - -
TM6 232 A 6.37x37 PAR1 3VW7 D2 receptor 6LUQ
TM6 233 L 6.38x38 PAR1 3VW7 κ receptor 4DJH
TM6 234 K 6.39x39 PAR1 3VW7 - -
TM6 235 S 6.40x40 PAR1 3VW7 - -
TM6 236 L 6.41x41 PAR1 3VW7 LPA6 receptor 5XSZ
TM6 237 I 6.42x42 PAR1 3VW7 P2Y12 receptor 4NTJ
TM6 238 S 6.43x43 PAR1 3VW7 FPR2/ALX 6OMM
TM6 239 F 6.44x44 PAR1 3VW7 LPA6 receptor 5XSZ
TM6 240 L 6.45x45 PAR1 3VW7 5-HT2B receptor 5TVN
TM6 241 I 6.46x46 H1 receptor 3RZE PAR1 3VW7
TM6 242 L 6.47x47 H1 receptor 3RZE GPR52 6LI1
TM6 243 Y 6.48x48 PAR1 3VW7 P2Y1 receptor 4XNW
TM6 244 A 6.49x49 PAR1 3VW7 MC4 receptor 6W25
TM6 245 L 6.50x50 PAR1 3VW7 - -
TM6 246 S 6.51x51 PAR1 3VW7 PAR2 5NDD
TM6 247 F 6.52x52 PAR1 3VW7 5-HT2B receptor 5TVN
TM6 248 L 6.53x53 PAR1 3VW7 PAR2 5NDD
TM6 249 S 6.54x54 PAR1 3VW7 FFA1 receptor 5TZY
TM6 250 L 6.55x55 PAR1 3VW7 PAR1 3VW7
TM6 251 I 6.56x56 PAR1 3VW7 PAR1 3VW7
TM6 252 I 6.57x57 PAR1 3VW7 CysLT1 receptor 6RZ4
TM6 253 D 6.58x58 PAR1 3VW7 LPA1 receptor 4Z35
TM6 254 A 6.59x59 PAR1 3VW7 H1 receptor 3RZE
TM6 255 A 6.60x60 PAR1 3VW7 succinate receptor 6RNK
TM6 256 K 6.61x61 PAR1 3VW7 US28 4XT1
ECL3 257 F - - - - -
ECL3 258 I - - - - -
ECL3 259 S - - - - -
ECL3 260 M - - - - -
TM7 261 Q 7.31x31 PAR1 3VW7 5-HT2B receptor 5TVN
TM7 262 N 7.32x32 PAR1 3VW7 apelin receptor 5VBL
TM7 263 D 7.33x33 PAR1 3VW7 - -
TM7 264 F 7.34x34 PAR1 3VW7 MC4 receptor 6W25
TM7 265 Y 7.35x35 PAR1 3VW7 κ receptor 4DJH
TM7 266 W 7.36x36 PAR1 3VW7 Rhodopsin 6I9K
TM7 267 P 7.37x37 PAR1 3VW7 Rhodopsin 5W0P
TM7 268 W 7.38x38 PAR1 3VW7 - -
TM7 269 Q 7.39x39 PAR1 3VW7 - -
TM7 270 I 7.40x40 PAR1 3VW7 LPA6 receptor 5XSZ
TM7 271 A 7.41x41 PAR1 3VW7 LPA6 receptor 5XSZ
TM7 272 V 7.42x42 PAR1 3VW7 LPA6 receptor 5XSZ
TM7 273 Y 7.43x43 PAR1 3VW7 - -
TM7 274 L 7.44x44 - - - -
TM7 275 C 7.45x45 PAR1 3VW7 - -
TM7 276 I 7.46x46 PAR1 3VW7 - -
TM7 277 S 7.47x47 PAR1 3VW7 κ receptor 4DJH
TM7 278 V 7.48x48 PAR1 3VW7 5-HT2B receptor 5TVN
TM7 279 H 7.49x49 PAR1 3VW7 - -
TM7 280 P 7.50x50 PAR1 3VW7 PAR1 3VW7
TM7 281 F 7.51x51 PAR1 3VW7 PAR2 5NDD
TM7 282 I 7.52x52 PAR1 3VW7 PAR1 3VW7
TM7 283 L 7.53x53 PAR1 3VW7 ETB receptor 5X93
TM7 284 I 7.54x54 PAR1 3VW7 TP receptor 6IIV
TM7 285 F 7.55x55 H1 receptor 3RZE LPA6 receptor 5XSZ
TM7 286 S 7.56x56 H1 receptor 3RZE GPR52 6LI1
H8 287 N 8.47x47 H1 receptor 3RZE 5-HT2B receptor 5TVN
H8 288 L 8.48x48 H1 receptor 3RZE - -
H8 289 K 8.49x49 H1 receptor 3RZE CCR2 5T1A
H8 290 L 8.50x50 H1 receptor 3RZE MC4 receptor 6W25
H8 291 R 8.51x51 H1 receptor 3RZE PAR2 5NDD
H8 292 S 8.52x52 H1 receptor 3RZE 5-HT2A receptor 6A94
H8 293 V 8.53x53 H1 receptor 3RZE D4 receptor 5WIV
H8 294 F 8.54x54 H1 receptor 3RZE 5-HT2B receptor 5TVN
H8 295 S 8.55x55 H1 receptor 3RZE CCR2 5T1A
H8 296 Q 8.56x56 H1 receptor 3RZE LPA1 receptor 4Z36
H8 297 L 8.57x57 H1 receptor 3RZE GPR52 6LI1
H8 298 L 8.58x58 H1 receptor 3RZE PAR2 5NDD
H8 299 L 8.59x59 H1 receptor 3RZE apelin receptor 5VBL
H8 300 L 8.60x60 apelin receptor 5VBL - -
C-term 301 A - - - - -
C-term 302 R - - - - -
C-term 303 G - - - - -
C-term 304 F - - - - -
C-term 305 W - - - - -