TAS2R43 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

TAS2R43

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-09-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

MC4 receptor (sequence similarity: 26%) PDB: 6W25
Align

TEMPLATES

7JVR (D2 receptor)
6W25 (MC4 receptor)
6M9T (EP3 receptor)
4XES (NTS1 receptor)
3RZE (H1 receptor)
6DO1 (AT1 receptor)
5VBL (apelin receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 72.4 10.6 16.9
Side-chains 10.3 55.5 34.2

Number of backbone templates: 7
Number of rotamer templates: 65

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 1 M - - - - -
N-term 2 I - - - - -
N-term 3 T - - - - -
N-term 4 F - - - - -
N-term 5 L - - - - -
TM1 6 P 1.32x32 D2 receptor 7JVR GPBA receptor 7BW0
TM1 7 I 1.33x33 D2 receptor 7JVR GPR52 6LI1
TM1 8 I 1.34x34 D2 receptor 7JVR κ receptor 4DJH
TM1 9 F 1.35x35 MC4 receptor 6W25 - -
TM1 10 S 1.36x36 MC4 receptor 6W25 5-HT1A receptor 7E2X
TM1 11 S 1.37x37 MC4 receptor 6W25 PAR1 3VW7
TM1 12 L 1.38x38 MC4 receptor 6W25 D2 receptor 7JVR
TM1 13 V 1.39x39 MC4 receptor 6W25 α2C-adrenoceptor 6KUW
TM1 14 V 1.40x40 MC4 receptor 6W25 MC4 receptor 6W25
TM1 15 V 1.41x41 MC4 receptor 6W25 5-HT2A receptor 6A94
TM1 16 T 1.42x42 MC4 receptor 6W25 MT2 receptor 6ME7
TM1 17 F 1.43x43 MC4 receptor 6W25 apelin receptor 5VBL
TM1 18 V 1.44x44 MC4 receptor 6W25 MC4 receptor 6W25
TM1 19 I 1.45x45 MC4 receptor 6W25 MC4 receptor 6W25
TM1 20 G 1.46x46 MC4 receptor 6W25 apelin receptor 5VBL
TM1 21 N 1.47x47 MC4 receptor 6W25 - -
TM1 22 F 1.48x48 MC4 receptor 6W25 D2 receptor 7JVR
TM1 23 A 1.49x49 MC4 receptor 6W25 LPA1 receptor 4Z35
TM1 24 N 1.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM1 25 G 1.51x51 MC4 receptor 6W25 apelin receptor 5VBL
TM1 26 F 1.52x52 MC4 receptor 6W25 BLT1 receptor 5X33
TM1 27 I 1.53x53 MC4 receptor 6W25 DP2 receptor 6D27
TM1 28 A 1.54x54 MC4 receptor 6W25 NTS1 receptor 6UP7
TM1 29 L 1.55x55 MC4 receptor 6W25 5-HT2B receptor 5TVN
TM1 30 V 1.56x56 MC4 receptor 6W25 GPR52 6LI1
TM1 31 N 1.57x57 MC4 receptor 6W25 - -
TM1 32 S 1.58x58 MC4 receptor 6W25 D2 receptor 7JVR
TM1 33 I 1.59x59 MC4 receptor 6W25 - -
TM1 34 E 1.60x60 MC4 receptor 6W25 D2 receptor 7JVR
TM1 35 W 1.61x61 EP3 receptor 6M9T - -
TM1 36 F 1.62x62 EP3 receptor 6M9T - -
ICL1 37 K 12.48x48 - - - -
ICL1 38 R 12.49x49 D2 receptor 7JVR β2-adrenoceptor 2RH1
ICL1 39 Q 12.50x50 D2 receptor 7JVR - -
ICL1 40 K 12.51x51 - - - -
TM2 41 I 2.36x36 NTS1 receptor 4XES - -
TM2 42 S 2.37x37 MC4 receptor 6W25 MC4 receptor 6W25
TM2 43 F 2.38x38 MC4 receptor 6W25 - -
TM2 44 A 2.39x39 MC4 receptor 6W25 apelin receptor 5VBL
TM2 45 D 2.40x40 MC4 receptor 6W25 apelin receptor 5VBL
TM2 46 Q 2.41x41 MC4 receptor 6W25 - -
TM2 47 I 2.42x42 MC4 receptor 6W25 Rhodopsin 1U19
TM2 48 L 2.43x43 MC4 receptor 6W25 5-HT2C receptor 6BQH
TM2 49 T 2.44x44 MC4 receptor 6W25 β2-adrenoceptor 3SN6
TM2 50 A 2.45x45 MC4 receptor 6W25 - -
TM2 51 L 2.46x46 MC4 receptor 6W25 MC4 receptor 6W25
TM2 52 A 2.47x47 MC4 receptor 6W25 MC4 receptor 6W25
TM2 53 V 2.48x48 MC4 receptor 6W25 MC4 receptor 6W25
TM2 54 S 2.49x49 MC4 receptor 6W25 CCK1 receptor 7MBX
TM2 55 R 2.50x50 MC4 receptor 6W25 - -
TM2 56 V 2.51x51 MC4 receptor 6W25 A1 receptor 5UEN
TM2 57 G 2.52x52 MC4 receptor 6W25 Rhodopsin 6I9K
TM2 58 L 2.53x53 MC4 receptor 6W25 5-HT2A receptor 6A94
TM2 59 L 2.54x54 MC4 receptor 6W25 AT1 receptor 4ZUD
TM2 60 W 2.55x55 MC4 receptor 6W25 - -
TM2 61 V 2.56x56 MC4 receptor 6W25 D2 receptor 7JVR
TM2 62 L 2.57x57 MC4 receptor 6W25 MC4 receptor 6W25
TM2 63 L 2.58x58 MC4 receptor 6W25 GPR52 6LI1
TM2 64 L 2.59x59 MC4 receptor 6W25 5-HT2C receptor 6BQH
TM2 65 N 2.60x60 MC4 receptor 6W25 H1 receptor 3RZE
TM2 66 W 2.61x61 MC4 receptor 6W25 - -
TM2 67 Y 2.62x62 MC4 receptor 6W25 D2 receptor 7JVR
TM2 68 S 2.63x63 MC4 receptor 6W25 GPR52 6LI1
TM2 69 T 2.64x64 MC4 receptor 6W25 apelin receptor 5VBL
TM2 70 V 2.65x65 MC4 receptor 6W25 D2 receptor 7JVR
TM2 71 L 2.66x66 MC4 receptor 6W25 MC4 receptor 6W25
ECL1 72 N - - - - -
ECL1 73 P - H1 receptor 3RZE - -
ECL1 74 A - H1 receptor 3RZE - -
ECL1 75 F - H1 receptor 3RZE - -
ECL1 76 N - - - - -
TM3 77 S 3.21x21 MC4 receptor 6W25 - -
TM3 78 V 3.22x22 MC4 receptor 6W25 MC4 receptor 6W25
TM3 79 E 3.23x23 MC4 receptor 6W25 MT2 receptor 6ME6
TM3 80 V 3.24x24 MC4 receptor 6W25 CCK1 receptor 7MBX
TM3 81 R 3.25x25 MC4 receptor 6W25 - -
TM3 82 T 3.26x26 MC4 receptor 6W25 US28 5WB1
TM3 83 T 3.27x27 MC4 receptor 6W25 CCK1 receptor 7MBX
TM3 84 A 3.28x28 MC4 receptor 6W25 AT1 receptor 4ZUD
TM3 85 Y 3.29x29 MC4 receptor 6W25 NTS1 receptor 4XES
TM3 86 N 3.30x30 MC4 receptor 6W25 - -
TM3 87 I 3.31x31 MC4 receptor 6W25 GPR52 6LI1
TM3 88 W 3.32x32 MC4 receptor 6W25 - -
TM3 89 A 3.33x33 MC4 receptor 6W25 CCR6 6WWZ
TM3 90 V 3.34x34 MC4 receptor 6W25 GPR52 6LI1
TM3 91 I 3.35x35 MC4 receptor 6W25 - -
TM3 92 N 3.36x36 MC4 receptor 6W25 - -
TM3 93 H 3.37x37 MC4 receptor 6W25 - -
TM3 94 F 3.38x38 MC4 receptor 6W25 - -
TM3 95 S 3.39x39 MC4 receptor 6W25 MC4 receptor 6W25
TM3 96 N 3.40x40 MC4 receptor 6W25 - -
TM3 97 W 3.41x41 MC4 receptor 6W25 GPR52 6LI1
TM3 98 L 3.42x42 MC4 receptor 6W25 AT1 receptor 4ZUD
TM3 99 A 3.43x43 MC4 receptor 6W25 EP3 receptor 6AK3
TM3 100 T 3.44x44 MC4 receptor 6W25 apelin receptor 5VBL
TM3 101 T 3.45x45 MC4 receptor 6W25 μ receptor 5C1M
TM3 102 L 3.46x46 MC4 receptor 6W25 apelin receptor 5VBL
TM3 103 S 3.47x47 MC4 receptor 6W25 GPR52 6LI1
TM3 104 I 3.48x48 MC4 receptor 6W25 D2 receptor 7JVR
TM3 105 F 3.49x49 MC4 receptor 6W25 CysLT1 receptor 6RZ4
TM3 106 Y 3.50x50 MC4 receptor 6W25 - -
TM3 107 L 3.51x51 MC4 receptor 6W25 - -
TM3 108 L 3.52x52 MC4 receptor 6W25 GPR52 6LI1
TM3 109 K 3.53x53 MC4 receptor 6W25 P2Y12 receptor 4NTJ
TM3 110 I 3.54x54 MC4 receptor 6W25 MC4 receptor 6W25
TM3 111 A 3.55x55 MC4 receptor 6W25 D2 receptor 7JVR
TM3 112 N 3.56x56 MC4 receptor 6W25 5-HT2C receptor 6BQG
ICL2 113 F - - - - -
ICL2 114 S - - - - -
ICL2 115 N 34.50x50 AT1 receptor 6DO1 - -
ICL2 116 F 34.51x51 AT1 receptor 6DO1 NTS1 receptor 4XES
ICL2 117 I 34.52x52 AT1 receptor 6DO1 - -
ICL2 118 F 34.53x53 AT1 receptor 6DO1 - -
ICL2 119 L 34.54x54 AT1 receptor 6DO1 κ receptor 6B73
ICL2 120 H 34.55x55 AT1 receptor 6DO1 D3 receptor 3PBL
ICL2 121 L 34.56x56 AT1 receptor 6DO1 GPR52 6LI1
ICL2 122 K 34.57x57 - - - -
TM4 123 R 4.38x38 MC4 receptor 6W25 OT receptor 6TPK
TM4 124 R 4.39x39 MC4 receptor 6W25 5-HT2C receptor 6BQH
TM4 125 V 4.40x40 MC4 receptor 6W25 apelin receptor 5VBL
TM4 126 K 4.41x41 MC4 receptor 6W25 5-HT2C receptor 6BQG
TM4 127 S 4.42x42 MC4 receptor 6W25 CCR9 5LWE
TM4 128 V 4.43x43 MC4 receptor 6W25 CCR2 5T1A
TM4 129 I 4.44x44 MC4 receptor 6W25 MC4 receptor 6W25
TM4 130 L 4.45x45 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM4 131 V 4.46x46 MC4 receptor 6W25 β1-adrenoceptor 7BVQ
TM4 132 M 4.47x47 MC4 receptor 6W25 - -
TM4 133 L 4.48x48 MC4 receptor 6W25 GPR52 6LI1
TM4 134 L 4.49x49 MC4 receptor 6W25 apelin receptor 5VBL
TM4 135 G 4.50x50 MC4 receptor 6W25 - -
TM4 136 P 4.51x51 MC4 receptor 6W25 - -
TM4 137 L 4.52x52 MC4 receptor 6W25 D2 receptor 7JVR
TM4 138 L 4.53x53 MC4 receptor 6W25 - -
TM4 139 F 4.54x54 MC4 receptor 6W25 D2 receptor 7JVR
TM4 140 L 4.55x55 MC4 receptor 6W25 GPR52 6LI1
TM4 141 A 4.56x56 MC4 receptor 6W25 AT1 receptor 4ZUD
TM4 142 C 4.57x57 MC4 receptor 6W25 CCR9 5LWE
TM4 143 H 4.58x58 MC4 receptor 6W25 - -
TM4 144 L 4.59x59 MC4 receptor 6W25 MC4 receptor 6W25
TM4 145 F 4.60x60 MC4 receptor 6W25 MC4 receptor 6W25
TM4 146 V 4.61x61 MC4 receptor 6W25 apelin receptor 5VBL
TM4 147 I 4.62x62 MC4 receptor 6W25 MC4 receptor 6W25
TM4 148 N 4.63x63 MC4 receptor 6W25 - -
ECL2 149 M - - - - -
ECL2 150 N - - - - -
ECL2 151 E - - - - -
ECL2 152 I - - - - -
ECL2 153 V - - - - -
ECL2 154 R - - - - -
ECL2 155 T - - - - -
ECL2 156 K - - - - -
ECL2 157 E - - - - -
ECL2 158 F - - - - -
ECL2 159 E - - - - -
ECL2 160 G - - - - -
ECL2 161 N - - - - -
ECL2 162 M - - - - -
ECL2 163 T - - - - -
ECL2 164 W - - - - -
ECL2 165 K - - - - -
ECL2 166 I - - - - -
ECL2 167 K - - - - -
ECL2 168 L - - - - -
TM5 169 K 5.32x32 apelin receptor 5VBL CysLT2 receptor 6RZ6
TM5 170 S 5.33x33 apelin receptor 5VBL κ receptor 4DJH
TM5 171 A 5.34x34 apelin receptor 5VBL apelin receptor 5VBL
TM5 172 M 5.35x35 apelin receptor 5VBL CCK1 receptor 7MBX
TM5 173 Y 5.36x36 MC4 receptor 6W25 - -
TM5 174 F 5.37x37 MC4 receptor 6W25 PAR2 5NDD
TM5 175 S 5.38x38 MC4 receptor 6W25 CCK1 receptor 7MBX
TM5 176 N 5.39x39 MC4 receptor 6W25 - -
TM5 177 M 5.40x40 MC4 receptor 6W25 5-HT2B receptor 5TVN
TM5 178 T 5.41x41 MC4 receptor 6W25 GPR52 6LI1
TM5 179 V 5.42x42 MC4 receptor 6W25 NTS1 receptor 4XES
TM5 180 T 5.43x43 MC4 receptor 6W25 H1 receptor 3RZE
TM5 181 M 5.44x44 MC4 receptor 6W25 CCR7 6QZH
TM5 182 V 5.45x45 MC4 receptor 6W25 GPR52 6LI1
TM5 183 A 5.46x46 MC4 receptor 6W25 5-HT2B receptor 5TVN
TM5 184 N 5.47x47 MC4 receptor 6W25 LPA1 receptor 4Z35
TM5 185 L 5.48x48 MC4 receptor 6W25 AT1 receptor 4ZUD
TM5 186 V 5.49x49 MC4 receptor 6W25 D2 receptor 7JVR
TM5 187 P 5.50x50 MC4 receptor 6W25 GPR52 6LI1
TM5 188 F 5.51x51 MC4 receptor 6W25 D2 receptor 7JVR
TM5 189 T 5.52x52 MC4 receptor 6W25 5-HT2C receptor 6BQH
TM5 190 L 5.53x53 MC4 receptor 6W25 MC4 receptor 6W25
TM5 191 T 5.54x54 MC4 receptor 6W25 D2 receptor 7JVR
TM5 192 L 5.55x55 MC4 receptor 6W25 D2 receptor 7JVR
TM5 193 L 5.56x56 MC4 receptor 6W25 D2 receptor 7JVR
TM5 194 S 5.57x57 MC4 receptor 6W25 AT1 receptor 4ZUD
TM5 195 F 5.58x58 MC4 receptor 6W25 FFA1 receptor 5TZY
TM5 196 M 5.59x59 MC4 receptor 6W25 CB1 receptor 5TGZ
TM5 197 L 5.60x60 MC4 receptor 6W25 5-HT2C receptor 6BQH
TM5 198 L 5.61x61 MC4 receptor 6W25 Rhodopsin 4X1H
TM5 199 I 5.62x62 MC4 receptor 6W25 GPR52 6LI0
TM5 200 C 5.63x63 MC4 receptor 6W25 ETB receptor 5X93
TM5 201 S 5.64x64 MC4 receptor 6W25 5-HT2A receptor 6A94
TM5 202 L 5.65x65 D2 receptor 7JVR D2 receptor 7JVR
TM5 203 C 5.66x66 D2 receptor 7JVR GPR52 6LI1
TM5 204 K 5.67x67 D2 receptor 7JVR 5-HT2A receptor 6A94
TM5 205 H 5.68x68 D2 receptor 7JVR MC4 receptor 7AUE
TM5 206 L 5.69x69 D2 receptor 7JVR β2-adrenoceptor 3SN6
TM5 207 K 5.70x70 D2 receptor 7JVR D2 receptor 7JVR
TM5 208 K 5.71x71 D2 receptor 7JVR D3 receptor 7CMV
TM5 209 M 5.72x72 D2 receptor 7JVR CB1 receptor 6N4B
ICL3 210 Q - - - - -
ICL3 211 L - - - - -
ICL3 212 H - - - - -
ICL3 213 G - - - - -
ICL3 214 K - - - - -
ICL3 215 G - - - - -
ICL3 216 S - - - - -
ICL3 217 Q - - - - -
ICL3 218 D - MC4 receptor 6W25 - -
TM6 219 P 6.29x29 MC4 receptor 6W25 P2Y1 receptor 4XNW
TM6 220 S 6.30x30 MC4 receptor 6W25 CysLT2 receptor 6RZ6
TM6 221 T 6.31x31 MC4 receptor 6W25 D1 receptor 7JVQ
TM6 222 K 6.32x32 MC4 receptor 6W25 MC4 receptor 6W25
TM6 223 V 6.33x33 MC4 receptor 6W25 CCK1 receptor 7MBX
TM6 224 H 6.34x34 MC4 receptor 6W25 - -
TM6 225 I 6.35x35 MC4 receptor 6W25 MC4 receptor 6W25
TM6 226 K 6.36x36 MC4 receptor 6W25 PAR2 5NDD
TM6 227 A 6.37x37 MC4 receptor 6W25 D2 receptor 6LUQ
TM6 228 L 6.38x38 MC4 receptor 6W25 κ receptor 4DJH
TM6 229 Q 6.39x39 MC4 receptor 6W25 - -
TM6 230 T 6.40x40 MC4 receptor 6W25 EP4 receptor 5YWY
TM6 231 V 6.41x41 MC4 receptor 6W25 apelin receptor 5VBL
TM6 232 I 6.42x42 MC4 receptor 6W25 CCR2 5T1A
TM6 233 S 6.43x43 MC4 receptor 6W25 FPR2/ALX 6OMM
TM6 234 F 6.44x44 MC4 receptor 6W25 MC4 receptor 6W25
TM6 235 L 6.45x45 MC4 receptor 6W25 5-HT2C receptor 6BQH
TM6 236 L 6.46x46 MC4 receptor 6W25 apelin receptor 5VBL
TM6 237 L 6.47x47 MC4 receptor 6W25 GPR52 6LI1
TM6 238 C 6.48x48 MC4 receptor 6W25 - -
TM6 239 A 6.49x49 MC4 receptor 6W25 MC4 receptor 6W25
TM6 240 I 6.50x50 MC4 receptor 6W25 - -
TM6 241 Y 6.51x51 MC4 receptor 6W25 GPR52 6LI1
TM6 242 F 6.52x52 MC4 receptor 6W25 MC4 receptor 6W25
TM6 243 L 6.53x53 MC4 receptor 6W25 MC4 receptor 6W25
TM6 244 S 6.54x54 MC4 receptor 6W25 α2B-adrenoceptor 6K42
TM6 245 I 6.55x55 MC4 receptor 6W25 κ receptor 4DJH
TM6 246 M 6.56x56 MC4 receptor 6W25 H1 receptor 3RZE
TM6 247 I 6.57x57 MC4 receptor 6W25 M2 receptor 5YC8
TM6 248 S 6.58x58 MC4 receptor 6W25 5-HT2C receptor 6BQH
TM6 249 V 6.59x59 MC4 receptor 6W25 5-HT2C receptor 6BQH
TM6 250 W 6.60x60 MC4 receptor 6W25 Y1 receptor 5ZBH
TM6 251 S 6.61x61 MC4 receptor 6W25 5-ht1E receptor 7E33
ECL3 252 F - - - - -
ECL3 253 G - - - - -
ECL3 254 S - - - - -
ECL3 255 L - - - - -
ECL3 256 E - - - - -
TM7 257 N 7.31x31 D2 receptor 7JVR M2 receptor 5YC8
TM7 258 K 7.32x32 D2 receptor 7JVR 5-HT2C receptor 6BQH
TM7 259 P 7.33x33 MC4 receptor 6W25 CCK1 receptor 7MBX
TM7 260 V 7.34x34 MC4 receptor 6W25 CysLT1 receptor 6RZ4
TM7 261 F 7.35x35 MC4 receptor 6W25 GPR52 6LI1
TM7 262 M 7.36x36 MC4 receptor 6W25 - -
TM7 263 F 7.37x37 MC4 receptor 6W25 D2 receptor 7JVR
TM7 264 C 7.38x38 MC4 receptor 6W25 - -
TM7 265 K 7.39x39 MC4 receptor 6W25 - -
TM7 266 A 7.40x40 MC4 receptor 6W25 - -
TM7 267 I 7.41x41 MC4 receptor 6W25 MC4 receptor 6W25
TM7 268 R 7.42x42 MC4 receptor 6W25 - -
TM7 269 F 7.43x43 MC4 receptor 6W25 AT1 receptor 4ZUD
TM7 270 S 7.44x44 - - - -
TM7 271 Y 7.45x45 MC4 receptor 6W25 - -
TM7 272 P 7.46x46 MC4 receptor 6W25 EP4 receptor 5YWY
TM7 273 S 7.47x47 MC4 receptor 6W25 κ receptor 4DJH
TM7 274 I 7.48x48 MC4 receptor 6W25 MC4 receptor 6W25
TM7 275 H 7.49x49 MC4 receptor 6W25 - -
TM7 276 P 7.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM7 277 F 7.51x51 MC4 receptor 6W25 apelin receptor 5VBL
TM7 278 I 7.52x52 MC4 receptor 6W25 MC4 receptor 6W25
TM7 279 L 7.53x53 MC4 receptor 6W25 ETB receptor 5X93
TM7 280 I 7.54x54 MC4 receptor 6W25 EP4 receptor 5YWY
TM7 281 W 7.55x55 MC4 receptor 6W25 Y2 receptor 7DDZ
TM7 282 G 7.56x56 MC4 receptor 6W25 GPBA receptor 7CFN
H8 283 N 8.47x47 MC4 receptor 6W25 D2 receptor 7JVR
H8 284 K 8.48x48 MC4 receptor 6W25 5-HT2C receptor 6BQH
H8 285 K 8.49x49 MC4 receptor 6W25 CCR2 5T1A
H8 286 L 8.50x50 MC4 receptor 6W25 MC4 receptor 6W25
H8 287 K 8.51x51 MC4 receptor 6W25 AT1 receptor 6DO1
H8 288 Q 8.52x52 MC4 receptor 6W25 apelin receptor 5VBL
H8 289 T 8.53x53 MC4 receptor 6W25 MC4 receptor 6W25
H8 290 F 8.54x54 MC4 receptor 6W25 MC4 receptor 6W25
H8 291 L 8.55x55 MC4 receptor 6W25 D2 receptor 7JVR
H8 292 S 8.56x56 MC4 receptor 6W25 apelin receptor 5VBL
H8 293 V 8.57x57 MC4 receptor 6W25 AT2 receptor 5UNG
H8 294 F 8.58x58 MC4 receptor 6W25 CCR2 5T1A
H8 295 W 8.59x59 MC4 receptor 6W25 - -
H8 296 Q 8.60x60 MC4 receptor 6W25 succinate receptor 6IBB
C-term 297 M - - - - -
C-term 298 R - - - - -
C-term 299 Y - - - - -
C-term 300 W - - - - -
C-term 301 V - - - - -