TAS2R60 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-04-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

PAR1 (sequence similarity: 19%) PDB: 3VW7

TEMPLATES

3VW7 (PAR1)
5TZY (FFA1 receptor)
5VBL (apelin receptor)
5ZKQ (PAF receptor)
4PXZ (P2Y12 receptor)
5C1M (μ receptor)
7JVR (D2 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 69.7 13.7 16.6
Side-chains 9.4 55.0 35.5

Number of backbone templates: 7
Number of rotamer templates: 49

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 12 V - PAR1 3VW7 PAR1 3VW7
N-term 13 T - PAR1 3VW7 PAR1 3VW7
N-term 14 D - PAR1 3VW7 PAR1 3VW7
N-term 15 K - PAR1 3VW7 PAR1 3VW7
N-term 16 K - PAR1 3VW7 PAR1 3VW7
TM1 17 A 1.32x32 PAR1 3VW7 μ receptor 5C1M
TM1 18 I 1.33x33 PAR1 3VW7 GPR52 6LI1
TM1 19 I 1.34x34 PAR1 3VW7 κ receptor 4DJH
TM1 20 L 1.35x35 PAR1 3VW7 P2Y1 receptor 4XNW
TM1 21 V 1.36x36 PAR1 3VW7 H1 receptor 7DFL
TM1 22 T 1.37x37 PAR1 3VW7 CysLT1 receptor 6RZ4
TM1 23 I 1.38x38 PAR1 3VW7 apelin receptor 5VBL
TM1 24 L 1.39x39 PAR1 3VW7 5-HT2B receptor 5TVN
TM1 25 L 1.40x40 PAR1 3VW7 CysLT2 receptor 6RZ6
TM1 26 L 1.41x41 PAR1 3VW7 5-HT2B receptor 5TVN
TM1 27 L 1.42x42 PAR1 3VW7 MC4 receptor 6W25
TM1 28 R 1.43x43 PAR1 3VW7 - -
TM1 29 L 1.44x44 PAR1 3VW7 apelin receptor 5VBL
TM1 30 V 1.45x45 PAR1 3VW7 PAR1 3VW7
TM1 31 A 1.46x46 PAR1 3VW7 PAR2 5NDD
TM1 32 I 1.47x47 PAR1 3VW7 5-HT2B receptor 5TVN
TM1 33 A 1.48x48 PAR1 3VW7 GPR52 6LI1
TM1 34 G 1.49x49 PAR1 3VW7 CysLT2 receptor 6RZ6
TM1 35 N 1.50x50 PAR1 3VW7 PAR1 3VW7
TM1 36 G 1.51x51 PAR1 3VW7 CysLT2 receptor 6RZ6
TM1 37 F 1.52x52 PAR1 3VW7 CysLT1 receptor 6RZ4
TM1 38 I 1.53x53 PAR1 3VW7 DP2 receptor 6D27
TM1 39 T 1.54x54 PAR1 3VW7 - -
TM1 40 A 1.55x55 PAR1 3VW7 5-HT1B receptor 4IAQ
TM1 41 A 1.56x56 PAR1 3VW7 MC4 receptor 6W25
TM1 42 L 1.57x57 PAR1 3VW7 CysLT1 receptor 6RZ4
TM1 43 G 1.58x58 PAR1 3VW7 DP2 receptor 6D27
TM1 44 V 1.59x59 PAR1 3VW7 LPA1 receptor 4Z35
TM1 45 E 1.60x60 PAR1 3VW7 C5a1 receptor 6C1Q
TM1 46 W 1.61x61 FFA1 receptor 5TZY - -
TM1 47 V 1.62x62 FFA1 receptor 5TZY - -
ICL1 48 L 12.48x48 - - - -
ICL1 49 R 12.49x49 apelin receptor 5VBL apelin receptor 5VBL
ICL1 50 R 12.50x50 apelin receptor 5VBL - -
ICL1 51 M 12.51x51 - - - -
TM2 52 L 2.36x36 PAF receptor 5ZKQ - -
TM2 53 L 2.37x37 PAR1 3VW7 - -
TM2 54 P 2.38x38 PAR1 3VW7 PAR1 3VW7
TM2 55 C 2.39x39 PAR1 3VW7 - -
TM2 56 D 2.40x40 PAR1 3VW7 apelin receptor 5VBL
TM2 57 K 2.41x41 PAR1 3VW7 CXCR4 3ODU
TM2 58 L 2.42x42 PAR1 3VW7 D2 receptor 7JVR
TM2 59 L 2.43x43 PAR1 3VW7 5-HT2B receptor 5TVN
TM2 60 V 2.44x44 PAR1 3VW7 PAF receptor 5ZKQ
TM2 61 S 2.45x45 PAR1 3VW7 MC4 receptor 6W25
TM2 62 L 2.46x46 PAR1 3VW7 PAR1 3VW7
TM2 63 G 2.47x47 PAR1 3VW7 FFA1 receptor 5TZY
TM2 64 A 2.48x48 PAR1 3VW7 LPA1 receptor 4Z35
TM2 65 S 2.49x49 PAR1 3VW7 CysLT2 receptor 6RZ6
TM2 66 R 2.50x50 PAR1 3VW7 - -
TM2 67 F 2.51x51 PAR1 3VW7 P2Y1 receptor 4XNW
TM2 68 C 2.52x52 PAR1 3VW7 AT1 receptor 4ZUD
TM2 69 L 2.53x53 PAR1 3VW7 FFA1 receptor 5TZY
TM2 70 Q 2.54x54 PAR1 3VW7 EP3 receptor 6AK3
TM2 71 S 2.55x55 PAR1 3VW7 PAR1 3VW7
TM2 72 V 2.56x56 PAR1 3VW7 PAR1 3VW7
TM2 73 V 2.57x57 PAR1 3VW7 OT receptor 6TPK
TM2 74 M 2.58x58 PAR1 3VW7 Rhodopsin 6I9K
TM2 75 G 2.59x59 PAR1 3VW7 - -
TM2 76 K 2.60x60 PAR1 3VW7 PAR1 3VW7
TM2 77 T 2.61x61 PAR1 3VW7 MC4 receptor 6W25
TM2 78 I 2.62x62 PAR1 3VW7 MC4 receptor 6W25
TM2 79 Y 2.63x63 PAR1 3VW7 PAR1 3VW7
TM2 80 V 2.64x64 PAR1 3VW7 - -
TM2 81 F 2.65x65 PAR1 3VW7 PAR1 3VW7
TM2 82 L 2.66x66 PAR1 3VW7 MC4 receptor 6W25
ECL1 83 H - - - - -
ECL1 84 P - P2Y12 receptor 4PXZ - -
ECL1 85 M - - - - -
TM3 86 A 3.18x18 P2Y12 receptor 4PXZ - -
TM3 87 F 3.19x19 P2Y12 receptor 4PXZ - -
TM3 88 P 3.20x20 P2Y12 receptor 4PXZ - -
TM3 89 Y 3.21x21 PAR1 3VW7 A1 receptor 5UEN
TM3 90 N 3.22x22 PAR1 3VW7 μ receptor 5C1M
TM3 91 P 3.23x23 PAR1 3VW7 H1 receptor 3RZE
TM3 92 V 3.24x24 PAR1 3VW7 P2Y12 receptor 4NTJ
TM3 93 L 3.25x25 PAR1 3VW7 - -
TM3 94 Q 3.26x26 PAR1 3VW7 GPR52 6LI1
TM3 95 F 3.27x27 PAR1 3VW7 PAR1 3VW7
TM3 96 L 3.28x28 PAR1 3VW7 PAR2 5NDD
TM3 97 A 3.29x29 PAR1 3VW7 FFA1 receptor 5TZY
TM3 98 F 3.30x30 PAR1 3VW7 5-HT2B receptor 5TVN
TM3 99 Q 3.31x31 PAR1 3VW7 - -
TM3 100 W 3.32x32 PAR1 3VW7 - -
TM3 101 D 3.33x33 PAR1 3VW7 LPA1 receptor 4Z35
TM3 102 F 3.34x34 PAR1 3VW7 P2Y12 receptor 4NTJ
TM3 103 L 3.35x35 PAR1 3VW7 GPR52 6LI1
TM3 104 N 3.36x36 PAR1 3VW7 - -
TM3 105 A 3.37x37 PAR1 3VW7 A2A receptor 4UHR
TM3 106 A 3.38x38 PAR1 3VW7 PAR1 3VW7
TM3 107 T 3.39x39 PAR1 3VW7 ETB receptor 5X93
TM3 108 L 3.40x40 PAR1 3VW7 TP receptor 6IIV
TM3 109 W 3.41x41 PAR1 3VW7 5-HT2B receptor 5TVN
TM3 110 S 3.42x42 PAR1 3VW7 MC4 receptor 6W25
TM3 111 S 3.43x43 PAR1 3VW7 - -
TM3 112 T 3.44x44 PAR1 3VW7 PAR1 3VW7
TM3 113 W 3.45x45 PAR1 3VW7 - -
TM3 114 L 3.46x46 PAR1 3VW7 CysLT2 receptor 6RZ6
TM3 115 S 3.47x47 PAR1 3VW7 PAR1 3VW7
TM3 116 V 3.48x48 PAR1 3VW7 MC4 receptor 6W25
TM3 117 F 3.49x49 PAR1 3VW7 CysLT1 receptor 6RZ4
TM3 118 Y 3.50x50 PAR1 3VW7 - -
TM3 119 C 3.51x51 PAR1 3VW7 CysLT1 receptor 6RZ4
TM3 120 V 3.52x52 PAR1 3VW7 5-HT2C receptor 6BQH
TM3 121 K 3.53x53 PAR1 3VW7 P2Y12 receptor 4NTJ
TM3 122 I 3.54x54 PAR1 3VW7 MC4 receptor 6W25
TM3 123 A 3.55x55 PAR1 3VW7 FFA1 receptor 5TZY
TM3 124 T 3.56x56 PAR1 3VW7 - -
ICL2 125 F - - - - -
ICL2 126 T - - - - -
ICL2 127 H 34.50x50 μ receptor 5C1M - -
ICL2 128 P 34.51x51 μ receptor 5C1M CB2 receptor 5ZTY
ICL2 129 V 34.52x52 μ receptor 5C1M BLT1 receptor 7K15
ICL2 130 F 34.53x53 μ receptor 5C1M - -
ICL2 131 F 34.54x54 μ receptor 5C1M CCR6 6WWZ
ICL2 132 W 34.55x55 μ receptor 5C1M - -
ICL2 133 L 34.56x56 μ receptor 5C1M LPA6 receptor 5XSZ
ICL2 134 K 34.57x57 - - - -
TM4 135 H 4.38x38 PAR1 3VW7 - -
TM4 136 K 4.39x39 PAR1 3VW7 P2Y1 receptor 4XNW
TM4 137 L 4.40x40 PAR1 3VW7 P2Y12 receptor 4PXZ
TM4 138 S 4.41x41 PAR1 3VW7 CysLT2 receptor 6RZ6
TM4 139 G 4.42x42 PAR1 3VW7 PAF receptor 5ZKQ
TM4 140 W 4.43x43 PAR1 3VW7 CysLT2 receptor 6RZ6
TM4 141 L 4.44x44 PAR1 3VW7 succinate receptor 6RNK
TM4 142 P 4.45x45 PAR1 3VW7 - -
TM4 143 W 4.46x46 PAR1 3VW7 - -
TM4 144 M 4.47x47 PAR1 3VW7 - -
TM4 145 L 4.48x48 PAR1 3VW7 P2Y1 receptor 4XNW
TM4 146 F 4.49x49 PAR1 3VW7 - -
TM4 147 S 4.50x50 PAR1 3VW7 - -
TM4 148 S 4.51x51 PAR1 3VW7 - -
TM4 149 V 4.52x52 PAR1 3VW7 ghrelin receptor 6KO5
TM4 150 G 4.53x53 PAR1 3VW7 - -
TM4 151 L 4.54x54 PAR1 3VW7 LPA6 receptor 5XSZ
TM4 152 S 4.55x55 PAR1 3VW7 LPA6 receptor 5XSZ
TM4 153 S 4.56x56 PAR1 3VW7 MC4 receptor 6W25
TM4 154 F 4.57x57 μ receptor 5C1M GPR52 6LI1
TM4 155 T 4.58x58 μ receptor 5C1M - -
TM4 156 T 4.59x59 μ receptor 5C1M BLT1 receptor 7K15
TM4 157 I 4.60x60 PAR1 3VW7 P2Y1 receptor 4XNW
TM4 158 L 4.61x61 PAR1 3VW7 PAR1 3VW7
TM4 159 F 4.62x62 PAR1 3VW7 LPA6 receptor 5XSZ
TM4 160 F 4.63x63 PAR1 3VW7 GPR52 6LI1
TM4 161 I 4.64x64 PAR1 3VW7 - -
ECL2 162 G - - - - -
ECL2 163 N - - - - -
ECL2 164 H - - - - -
ECL2 165 R - - - - -
ECL2 166 M - - - - -
ECL2 167 Y - - - - -
ECL2 168 Q - - - - -
ECL2 169 N - - - - -
ECL2 170 Y - - - - -
ECL2 171 L - - - - -
ECL2 172 R - - - - -
ECL2 173 N - - - - -
ECL2 174 H - - - - -
ECL2 175 L - - - - -
ECL2 176 Q - - - - -
ECL2 177 P - - - - -
ECL2 178 W - - - - -
ECL2 179 N - - - - -
ECL2 180 V - - - - -
ECL2 181 T - - - - -
ECL2 182 G - - - - -
ECL2 183 D - - - - -
ECL2 184 S - - - - -
ECL2 185 I - - - - -
ECL2 186 R - - - - -
TM5 187 S 5.32x32 PAR1 3VW7 BLT1 receptor 7K15
TM5 188 Y 5.33x33 PAR1 3VW7 - -
TM5 189 C 5.34x34 PAR1 3VW7 - -
TM5 190 E 5.35x35 PAR1 3VW7 - -
TM5 191 K 5.36x36 PAR1 3VW7 BLT1 receptor 5X33
TM5 192 F 5.37x37 PAR1 3VW7 P2Y1 receptor 4XNW
TM5 193 Y 5.38x38 PAR1 3VW7 PAR1 3VW7
TM5 194 L 5.39x39 PAR1 3VW7 CysLT1 receptor 6RZ4
TM5 195 F 5.40x40 PAR1 3VW7 GPR52 6LI1
TM5 196 P 5.41x41 PAR1 3VW7 - -
TM5 197 L 5.42x42 PAR1 3VW7 TP receptor 6IIV
TM5 198 K 5.43x43 PAR1 3VW7 DP2 receptor 6D27
TM5 199 M 5.44x44 PAR1 3VW7 US28 5WB1
TM5 200 I 5.45x45 PAR1 3VW7 PAR2 5NDD
TM5 201 T 5.46x46 PAR1 3VW7 BLT1 receptor 7K15
TM5 202 W 5.47x47 PAR1 3VW7 - -
TM5 203 T 5.48x48 PAR1 3VW7 Rhodopsin 5W0P
TM5 204 M 5.49x49 PAR1 3VW7 μ receptor 5C1M
TM5 205 P 5.50x50 PAR1 3VW7 PAR1 3VW7
TM5 206 T 5.51x51 PAR1 3VW7 H1 receptor 3RZE
TM5 207 A 5.52x52 PAR1 3VW7 MC4 receptor 6W25
TM5 208 V 5.53x53 PAR1 3VW7 succinate receptor 6RNK
TM5 209 F 5.54x54 PAR1 3VW7 - -
TM5 210 F 5.55x55 PAR1 3VW7 TP receptor 6IIV
TM5 211 I 5.56x56 PAR1 3VW7 CysLT2 receptor 6RZ6
TM5 212 C 5.57x57 PAR1 3VW7 PAR1 3VW7
TM5 213 M 5.58x58 PAR1 3VW7 - -
TM5 214 I 5.59x59 PAR1 3VW7 D2 receptor 7JVR
TM5 215 L 5.60x60 PAR1 3VW7 CysLT2 receptor 6RZ6
TM5 216 L 5.61x61 PAR1 3VW7 Rhodopsin 5W0P
TM5 217 I 5.62x62 PAR1 3VW7 PAR1 3VW7
TM5 218 T 5.63x63 PAR1 3VW7 - -
TM5 219 S 5.64x64 PAR1 3VW7 5-HT2A receptor 6A94
TM5 220 L 5.65x65 PAR1 3VW7 PAR1 3VW7
TM5 221 G 5.66x66 PAR1 3VW7 - -
TM5 222 R 5.67x67 PAR1 3VW7 - -
TM5 223 H 5.68x68 D2 receptor 7JVR Rhodopsin 6I9K
TM5 224 R 5.69x69 D2 receptor 7JVR D2 receptor 7JVR
TM5 225 K 5.70x70 D2 receptor 7JVR D2 receptor 7JVR
TM5 226 K 5.71x71 D2 receptor 7JVR β2-adrenoceptor 3SN6
TM5 227 A 5.72x72 D2 receptor 7JVR NTS1 receptor 7L0R
ICL3 228 L - - - - -
ICL3 229 L - - - - -
ICL3 230 T - - - - -
ICL3 231 T - - - - -
ICL3 232 S - - - - -
ICL3 233 G - - - - -
ICL3 234 F - - - - -
ICL3 235 R - - - - -
ICL3 236 E - - - - -
TM6 237 P 6.29x29 PAR1 3VW7 P2Y1 receptor 4XNW
TM6 238 S 6.30x30 PAR1 3VW7 CysLT2 receptor 6RZ6
TM6 239 V 6.31x31 PAR1 3VW7 A2A receptor 4UHR
TM6 240 Q 6.32x32 PAR1 3VW7 ghrelin receptor 6KO5
TM6 241 A 6.33x33 PAR1 3VW7 5-HT2B receptor 5TVN
TM6 242 H 6.34x34 PAR1 3VW7 - -
TM6 243 I 6.35x35 PAR1 3VW7 MC4 receptor 6W25
TM6 244 K 6.36x36 PAR1 3VW7 PAR2 5NDD
TM6 245 A 6.37x37 PAR1 3VW7 D2 receptor 6LUQ
TM6 246 L 6.38x38 PAR1 3VW7 μ receptor 5C1M
TM6 247 L 6.39x39 PAR1 3VW7 succinate receptor 6RNK
TM6 248 A 6.40x40 PAR1 3VW7 PAR1 3VW7
TM6 249 L 6.41x41 PAR1 3VW7 LPA6 receptor 5XSZ
TM6 250 L 6.42x42 PAR1 3VW7 CysLT2 receptor 6RZ6
TM6 251 S 6.43x43 PAR1 3VW7 FPR2/ALX 6OMM
TM6 252 F 6.44x44 PAR1 3VW7 MC4 receptor 6W25
TM6 253 A 6.45x45 PAR1 3VW7 TP receptor 6IIV
TM6 254 M 6.46x46 μ receptor 5C1M GPR52 6LI1
TM6 255 L 6.47x47 μ receptor 5C1M GPR52 6LI1
TM6 256 F 6.48x48 PAR1 3VW7 PAR1 3VW7
TM6 257 I 6.49x49 PAR1 3VW7 LPA6 receptor 5XSZ
TM6 258 S 6.50x50 PAR1 3VW7 - -
TM6 259 Y 6.51x51 PAR1 3VW7 CysLT2 receptor 6RZ6
TM6 260 F 6.52x52 PAR1 3VW7 MC4 receptor 6W25
TM6 261 L 6.53x53 PAR1 3VW7 MC4 receptor 6W25
TM6 262 S 6.54x54 PAR1 3VW7 FFA1 receptor 5TZY
TM6 263 L 6.55x55 PAR1 3VW7 PAR1 3VW7
TM6 264 V 6.56x56 PAR1 3VW7 LPA6 receptor 5XSZ
TM6 265 F 6.57x57 PAR1 3VW7 MC4 receptor 6W25
TM6 266 S 6.58x58 PAR1 3VW7 FFA1 receptor 5TZY
TM6 267 A 6.59x59 PAR1 3VW7 μ receptor 5C1M
TM6 268 A 6.60x60 PAR1 3VW7 succinate receptor 6RNK
TM6 269 G 6.61x61 PAR1 3VW7 apelin receptor 5VBL
ECL3 270 I - - - - -
ECL3 271 F - - - - -
ECL3 272 P - - - - -
ECL3 273 P - - - - -
TM7 274 L 7.31x31 PAR1 3VW7 κ receptor 4DJH
TM7 275 D 7.32x32 PAR1 3VW7 PAF receptor 5ZKQ
TM7 276 F 7.33x33 PAR1 3VW7 Rhodopsin 5W0P
TM7 277 K 7.34x34 PAR1 3VW7 P2Y12 receptor 4NTJ
TM7 278 F 7.35x35 PAR1 3VW7 GPR52 6LI1
TM7 279 W 7.36x36 PAR1 3VW7 Rhodopsin 6I9K
TM7 280 V 7.37x37 PAR1 3VW7 DP2 receptor 6D27
TM7 281 W 7.38x38 PAR1 3VW7 - -
TM7 282 E 7.39x39 PAR1 3VW7 - -
TM7 283 S 7.40x40 PAR1 3VW7 - -
TM7 284 V 7.41x41 PAR1 3VW7 OX2 receptor 5WQC
TM7 285 I 7.42x42 PAR1 3VW7 GPR52 6LI1
TM7 286 Y 7.43x43 PAR1 3VW7 - -
TM7 287 L 7.44x44 - - - -
TM7 288 C 7.45x45 PAR1 3VW7 - -
TM7 289 A 7.46x46 PAR1 3VW7 CysLT2 receptor 6RZ6
TM7 290 A 7.47x47 PAR1 3VW7 succinate receptor 6RNK
TM7 291 V 7.48x48 PAR1 3VW7 5-HT2B receptor 5TVN
TM7 292 H 7.49x49 PAR1 3VW7 - -
TM7 293 P 7.50x50 PAR1 3VW7 PAR1 3VW7
TM7 294 I 7.51x51 PAR1 3VW7 LPA6 receptor 5XSZ
TM7 295 I 7.52x52 PAR1 3VW7 PAR1 3VW7
TM7 296 L 7.53x53 PAR1 3VW7 ETB receptor 5X93
TM7 297 L 7.54x54 PAR1 3VW7 - -
TM7 298 F 7.55x55 apelin receptor 5VBL apelin receptor 5VBL
TM7 299 S 7.56x56 apelin receptor 5VBL GPR52 6LI1
H8 300 N 8.47x47 apelin receptor 5VBL 5-HT2B receptor 5TVN
H8 301 C 8.48x48 apelin receptor 5VBL - -
H8 302 R 8.49x49 apelin receptor 5VBL apelin receptor 5VBL
H8 303 L 8.50x50 apelin receptor 5VBL MC4 receptor 6W25
H8 304 R 8.51x51 apelin receptor 5VBL MC4 receptor 6W25
H8 305 A 8.52x52 apelin receptor 5VBL LPA1 receptor 4Z35
H8 306 V 8.53x53 apelin receptor 5VBL D4 receptor 5WIV
H8 307 L 8.54x54 apelin receptor 5VBL CysLT2 receptor 6RZ6
H8 308 K 8.55x55 apelin receptor 5VBL MC4 receptor 6W25
H8 309 S 8.56x56 apelin receptor 5VBL CysLT2 receptor 6RZ6
H8 310 R 8.57x57 apelin receptor 5VBL - -
H8 311 R 8.58x58 apelin receptor 5VBL - -
H8 312 S 8.59x59 apelin receptor 5VBL OX2 receptor 5WQC
H8 313 S 8.60x60 apelin receptor 5VBL MT1 receptor 6ME2
C-term 314 R - - - - -
C-term 315 C - - - - -
C-term 316 G - - - - -
C-term 317 T - - - - -
C-term 318 P - - - - -