TAS1R2 homology model

PROTEIN CLASS

Class C (Glutamate)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-11-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

mGlu5 receptor (sequence similarity: 16%) PDB: 6N51

TEMPLATES

7DD6 (CaS receptor)
7M3J (CaS receptor)
7DTW (CaS receptor)
7M3F (CaS receptor)
7M3E (CaS receptor)
7M3G (CaS receptor)
6N51 (mGlu5 receptor)
4OO9 (mGlu5 receptor)
7EPB (mGlu2 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 67.8 18.3 13.9
Side-chains 12.1 27.5 60.4

Number of backbone templates: 9
Number of rotamer templates: 17

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
TM1 563 E 1.37x37 CaS receptor 7DD6 CaS receptor 7DD6
TM1 564 A 1.38x38 mGlu5 receptor 6N51 mGlu2 receptor 7EPE
TM1 565 P 1.39x39 mGlu5 receptor 6N51 - -
TM1 566 T 1.40x40 mGlu5 receptor 6N51 - -
TM1 567 I 1.41x41 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 568 A 1.42x42 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 569 V 1.43x43 mGlu5 receptor 6N51 GABAB1 6W2Y
TM1 570 A 1.44x44 mGlu5 receptor 6N51 - -
TM1 571 L 1.45x45 mGlu5 receptor 6N51 CaS receptor 7DD6
TM1 572 L 1.46x46 mGlu5 receptor 6N51 mGlu4 receptor 7E9H
TM1 573 A 1.47x47 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 574 A 1.48x48 mGlu5 receptor 6N51 - -
TM1 575 L 1.49x49 mGlu5 receptor 6N51 CaS receptor 7DD6
TM1 576 G 1.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 577 F 1.51x51 mGlu5 receptor 6N51 - -
TM1 578 L 1.52x52 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 579 S 1.53x53 mGlu5 receptor 6N51 - -
TM1 580 T 1.54x54 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 581 L 1.55x55 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 582 A 1.56x56 mGlu5 receptor 6N51 GABAB2 7CA5
TM1 583 I 1.57x57 mGlu5 receptor 6N51 - -
TM1 584 L 1.58x58 mGlu5 receptor 6N51 CaS receptor 7DD6
TM1 585 V 1.59x59 mGlu5 receptor 6N51 mGlu5 receptor 6FFI
TM1 586 I 1.60x60 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM1 587 F 1.61x61 mGlu5 receptor 6N51 CaS receptor 7DD6
TM1 588 W 1.62x62 mGlu5 receptor 6N51 - -
TM1 589 R 1.63x63 CaS receptor 7DD6 mGlu2 receptor 7EPE
TM1 590 H 1.64x64 CaS receptor 7DD6 mGlu2 receptor 7EPE
ICL1 591 F - - - - -
ICL1 592 Q - CaS receptor 7DD6 - -
ICL1 593 T 12.47x47 CaS receptor 7DD6 CaS receptor 7DD6
ICL1 594 P 12.48x48 CaS receptor 7DD6 CaS receptor 7DD6
ICL1 595 I 12.49x49 CaS receptor 7DD6 CaS receptor 7DD6
ICL1 596 V 12.50x50 CaS receptor 7DD6 CaS receptor 7DD6
ICL1 597 R 12.51x51 CaS receptor 7DD6 - -
ICL1 598 S 12.52x52 CaS receptor 7DD6 mGlu5 receptor 6N51
ICL1 599 A 12.53x53 - - - -
TM2 600 G 2.35x35 mGlu5 receptor 6N51 mGlu2 receptor 7EPE
TM2 601 G 2.36x36 mGlu5 receptor 6N51 - -
TM2 602 P 2.37x37 mGlu5 receptor 6N51 - -
TM2 603 M 2.38x38 mGlu5 receptor 6N51 GABAB2 7C7Q
TM2 604 C 2.39x39 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 605 F 2.40x40 mGlu5 receptor 6N51 - -
TM2 606 L 2.41x41 mGlu5 receptor 6N51 CaS receptor 7DD6
TM2 607 M 2.42x42 mGlu5 receptor 6N51 - -
TM2 608 L 2.43x43 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 609 T 2.44x44 mGlu5 receptor 6N51 - -
TM2 610 L 2.45x45 mGlu5 receptor 6N51 - -
TM2 611 L 2.46x46 mGlu5 receptor 6N51 CaS receptor 7DD6
TM2 612 L 2.47x47 mGlu5 receptor 6N51 CaS receptor 7DD6
TM2 613 V 2.48x48 mGlu5 receptor 6N51 - -
TM2 614 A 2.49x49 mGlu5 receptor 6N51 GABAB1 6W2Y
TM2 615 Y 2.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 616 M 2.51x51 mGlu5 receptor 6N51 - -
TM2 617 V 2.52x52 mGlu5 receptor 6N51 - -
TM2 618 V 2.53x53 mGlu5 receptor 6N51 GABAB1 6W2Y
TM2 619 P 2.54x54 mGlu5 receptor 6N51 - -
TM2 620 V 2.55x55 mGlu5 receptor 6N51 - -
TM2 621 Y 2.56x56 CaS receptor 7M3J - -
TM2 622 V 2.57x57 CaS receptor 7M3J - -
ECL1 623 G - - - - -
ECL1 624 P - CaS receptor 7M3J - -
ECL1 625 P - - - - -
TM3 626 K 3.25x25 mGlu5 receptor 6N51 mGlu5 receptor 6FFI
TM3 627 V 3.26x26 mGlu5 receptor 6N51 - -
TM3 628 S 3.27x27 mGlu5 receptor 6N51 - -
TM3 629 T 3.28x28 mGlu5 receptor 6N51 CaS receptor 7DD6
TM3 630 C 3.29x29 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 631 L 3.30x30 mGlu5 receptor 6N51 - -
TM3 632 C 3.31x31 mGlu5 receptor 6N51 - -
TM3 633 R 3.32x32 mGlu5 receptor 6N51 CaS receptor 7M3G
TM3 634 Q 3.33x33 mGlu5 receptor 6N51 CaS receptor 7DD6
TM3 635 A 3.34x34 mGlu5 receptor 6N51 - -
TM3 636 L 3.35x35 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM3 637 F 3.36x36 mGlu5 receptor 6N51 CaS receptor 7DD6
TM3 638 P 3.37x37 mGlu5 receptor 6N51 - -
TM3 639 L 3.38x38 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 640 C 3.39x39 mGlu5 receptor 6N51 - -
TM3 641 F 3.40x40 mGlu5 receptor 6N51 CaS receptor 7DD6
TM3 642 T 3.41x41 mGlu5 receptor 6N51 GABAB2 7C7Q
TM3 643 I 3.42x42 mGlu5 receptor 6N51 mGlu7 receptor 7EPC
TM3 644 C 3.43x43 mGlu5 receptor 6N51 CaS receptor 7DD6
TM3 645 I 3.44x44 mGlu5 receptor 6N51 CaS receptor 7DD6
TM3 646 S 3.45x45 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 647 C 3.46x46 mGlu5 receptor 6N51 CaS receptor 7DD6
TM3 648 I 3.47x47 mGlu5 receptor 6N51 CaS receptor 7DD6
TM3 649 A 3.48x48 mGlu5 receptor 6N51 - -
TM3 650 V 3.49x49 mGlu5 receptor 6N51 CaS receptor 7DD6
TM3 651 R 3.50x50 mGlu5 receptor 6N51 - -
TM3 652 S 3.51x51 mGlu5 receptor 6N51 - -
TM3 653 F 3.52x52 mGlu5 receptor 6N51 - -
TM3 654 Q 3.53x53 mGlu5 receptor 6N51 - -
TM3 655 I 3.54x54 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 656 V 3.55x55 mGlu5 receptor 6N51 - -
TM3 657 C 3.56x56 mGlu5 receptor 6N51 - -
TM3 658 A 3.57x57 mGlu5 receptor 6N51 - -
TM3 659 F 3.58x58 mGlu5 receptor 6N51 mGlu2 receptor 7EPE
ICL2 660 K - - - - -
ICL2 661 M - - - - -
ICL2 662 A - - - - -
ICL2 663 S - - - - -
ICL2 664 R - - - - -
ICL2 665 F - - - - -
ICL2 666 P - - - - -
ICL2 667 R - - - - -
ICL2 668 A - - - - -
ICL2 669 Y - - - - -
ICL2 670 S - - - - -
ICL2 671 Y - - - - -
ICL2 672 W - - - - -
ICL2 673 V - - - - -
TM4 674 R 4.28x28 mGlu5 receptor 6N51 - -
TM4 675 Y 4.29x29 mGlu5 receptor 6N51 - -
TM4 676 Q 4.30x30 mGlu5 receptor 6N51 GABAB2 7EB2
TM4 677 G 4.31x31 mGlu5 receptor 6N51 - -
TM4 678 P 4.32x32 mGlu5 receptor 6N51 - -
TM4 679 Y 4.33x33 mGlu5 receptor 6N51 GABAB1 6W2Y
TM4 680 V 4.34x34 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 681 S 4.35x35 mGlu5 receptor 6N51 - -
TM4 682 M 4.36x36 mGlu5 receptor 6N51 - -
TM4 683 A 4.37x37 mGlu5 receptor 6N51 - -
TM4 684 F 4.38x38 mGlu5 receptor 6N51 - -
TM4 685 I 4.39x39 mGlu5 receptor 6N51 - -
TM4 686 T 4.40x40 mGlu5 receptor 6N51 CaS receptor 7DD6
TM4 687 V 4.41x41 mGlu5 receptor 6N51 - -
TM4 688 L 4.42x42 mGlu5 receptor 6N51 mGlu4 receptor 7E9H
TM4 689 K 4.43x43 mGlu5 receptor 6N51 - -
TM4 690 M 4.44x44 mGlu5 receptor 6N51 - -
TM4 691 V 4.45x45 mGlu5 receptor 6N51 CaS receptor 7DD6
TM4 692 I 4.46x46 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 693 V 4.47x47 mGlu5 receptor 6N51 mGlu2 receptor 7EPE
TM4 694 V 4.48x48 mGlu5 receptor 6N51 CaS receptor 7DD6
TM4 695 I 4.49x49 mGlu5 receptor 6N51 CaS receptor 7DD6
TM4 696 G 4.50x50 mGlu5 receptor 6N51 - -
TM4 697 M 4.51x51 mGlu5 receptor 6N51 - -
TM4 698 L 4.52x52 mGlu5 receptor 6N51 - -
TM4 699 A 4.53x53 mGlu5 receptor 6N51 - -
TM4 700 T 4.54x54 mGlu5 receptor 6N51 - -
ECL2 701 G - - - - -
ECL2 702 L - mGlu2 receptor 7EPB - -
ECL2 703 S - mGlu2 receptor 7EPB - -
ECL2 704 P - mGlu2 receptor 7EPB - -
ECL2 705 T - mGlu2 receptor 7EPB - -
ECL2 706 T - mGlu2 receptor 7EPB - -
ECL2 707 R - mGlu2 receptor 7EPB - -
ECL2 708 T - mGlu2 receptor 7EPB - -
ECL2 709 D - mGlu2 receptor 7EPB - -
ECL2 710 P - mGlu2 receptor 7EPB mGlu2 receptor 7EPB
ECL2 711 D - mGlu2 receptor 7EPB - -
ECL2 712 D - mGlu2 receptor 7EPB - -
ECL2 713 P - mGlu2 receptor 7EPB - -
ECL2 714 K - mGlu2 receptor 7EPB - -
ECL2 715 I - mGlu2 receptor 7EPB - -
ECL2 716 T - mGlu2 receptor 7EPB - -
ECL2 717 I - mGlu2 receptor 7EPB - -
ECL2 718 V - mGlu2 receptor 7EPB - -
ECL2 719 S - - - - -
ECL2 720 C 45.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
ECL2 721 N 45.51x51 mGlu5 receptor 6N51 mGlu5 receptor 6N51
ECL2 722 P 45.52x52 mGlu5 receptor 6N51 - -
ECL2 723 N - - - - -
ECL2 724 Y - - - - -
TM5 725 R 5.37x37 mGlu5 receptor 6N51 - -
TM5 726 N 5.38x38 mGlu5 receptor 6N51 - -
TM5 727 S 5.39x39 mGlu5 receptor 6N51 mGlu2 receptor 7MTS
TM5 728 L 5.40x40 mGlu5 receptor 6N51 CaS receptor 7DD6
TM5 729 L 5.41x41 mGlu5 receptor 6N51 mGlu2 receptor 7EPE
TM5 730 F 5.42x42 mGlu5 receptor 6N51 CaS receptor 7DD6
TM5 731 N 5.43x43 mGlu5 receptor 6N51 - -
TM5 732 T 5.44x44 mGlu5 receptor 6N51 - -
TM5 733 S 5.45x45 mGlu5 receptor 6N51 - -
TM5 734 L 5.46x46 mGlu5 receptor 6N51 - -
TM5 735 D 5.47x47 mGlu5 receptor 6N51 - -
TM5 736 L 5.48x48 mGlu5 receptor 6N51 - -
TM5 737 L 5.49x49 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 738 L 5.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 739 S 5.51x51 mGlu5 receptor 6N51 - -
TM5 740 V 5.52x52 mGlu5 receptor 6N51 - -
TM5 741 V 5.53x53 mGlu5 receptor 6N51 - -
TM5 742 G 5.54x54 mGlu5 receptor 6N51 GABAB2 7CA5
TM5 743 F 5.55x55 mGlu5 receptor 6N51 CaS receptor 7DD6
TM5 744 S 5.56x56 mGlu5 receptor 6N51 - -
TM5 745 F 5.57x57 mGlu5 receptor 6N51 CaS receptor 7DD6
TM5 746 A 5.58x58 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 747 Y 5.59x59 CaS receptor 7DTW - -
TM5 748 M 5.60x60 CaS receptor 7DTW - -
TM5 749 G 5.61x61 CaS receptor 7DTW - -
TM5 750 K 5.62x62 CaS receptor 7DTW - -
TM5 751 E 5.63x63 CaS receptor 7DTW - -
TM5 752 L 5.64x64 CaS receptor 7DTW - -
ICL3 753 P - - - - -
ICL3 754 T - CaS receptor 7DTW - -
ICL3 755 N - CaS receptor 7DTW - -
ICL3 756 Y - - - - -
TM6 757 N 6.34x34 CaS receptor 7M3F CaS receptor 7M3F
TM6 758 E 6.35x35 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 759 A 6.36x36 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 760 K 6.37x37 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 761 F 6.38x38 mGlu5 receptor 6N51 CaS receptor 7DD6
TM6 762 I 6.39x39 mGlu5 receptor 6N51 CaS receptor 7DD6
TM6 763 T 6.40x40 mGlu5 receptor 6N51 CaS receptor 7DD6
TM6 764 L 6.41x41 mGlu5 receptor 6N51 - -
TM6 765 S 6.42x42 mGlu5 receptor 6N51 CaS receptor 7DD6
TM6 766 M 6.43x43 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 767 T 6.44x44 mGlu5 receptor 6N51 - -
TM6 768 F 6.45x45 mGlu5 receptor 6N51 - -
TM6 769 Y 6.46x46 mGlu5 receptor 6N51 - -
TM6 770 F 6.47x47 mGlu5 receptor 6N51 CaS receptor 7DD6
TM6 771 T 6.48x48 mGlu5 receptor 6N51 - -
TM6 772 S 6.49x49 mGlu5 receptor 6N51 - -
TM6 773 S 6.50x50 mGlu5 receptor 6N51 - -
TM6 774 V 6.51x51 mGlu5 receptor 6N51 - -
TM6 775 S 6.52x52 mGlu5 receptor 6N51 CaS receptor 7DD6
TM6 776 L 6.53x53 mGlu5 receptor 6N51 - -
TM6 777 C 6.54x54 mGlu5 receptor 6N51 - -
TM6 778 T 6.55x55 mGlu5 receptor 6N51 - -
TM6 779 F 6.56x56 mGlu5 receptor 6N51 - -
TM6 780 M 6.57x57 mGlu5 receptor 6N51 - -
TM6 781 S 6.58x58 mGlu5 receptor 6N51 - -
TM6 782 A 6.59x59 mGlu5 receptor 6N51 - -
TM6 783 Y 6.60x60 CaS receptor 7M3F - -
ECL3 784 S - - - - -
TM7 785 G 7.25x26 CaS receptor 7M3E CaS receptor 7M3E
TM7 786 V 7.26x27 CaS receptor 7M3E - -
TM7 787 L 7.27x28 CaS receptor 7M3E - -
TM7 788 V 7.28x29 CaS receptor 7M3E CaS receptor 7M3E
TM7 789 T 7.29x30 mGlu5 receptor 6N51 mGlu2 receptor 7EPE
TM7 790 I 7.30x31 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 791 V 7.31x32 mGlu5 receptor 6N51 CaS receptor 7DD6
TM7 792 D 7.32x33 mGlu5 receptor 6N51 - -
TM7 793 L 7.33x34 mGlu5 receptor 6N51 - -
TM7 794 L 7.34x35 mGlu5 receptor 6N51 GABAB2 7C7Q
TM7 795 V 7.35x36 mGlu5 receptor 6N51 GABAB2 7C7Q
TM7 796 T 7.36x37 mGlu5 receptor 6N51 - -
TM7 797 V 7.37x38 mGlu5 receptor 6N51 GABAB1 6W2Y
TM7 798 L 7.38x39 mGlu5 receptor 6N51 mGlu2 receptor 7EPE
TM7 799 N 7.39x40 mGlu5 receptor 6N51 - -
TM7 800 L 7.40x41 mGlu5 receptor 6N51 - -
TM7 801 L 7.41x42 mGlu5 receptor 6N51 - -
TM7 802 A 7.42x43 mGlu5 receptor 6N51 - -
TM7 803 I 7.43x44 mGlu5 receptor 6N51 - -
TM7 804 S 7.44x45 mGlu5 receptor 6N51 - -
TM7 805 L 7.45x46 mGlu5 receptor 6N51 - -
TM7 806 G 7.46x47 mGlu5 receptor 6N51 - -
TM7 807 Y 7.47x471 mGlu5 receptor 6N51 - -
TM7 808 F 7.48x48 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 809 G 7.49x49 mGlu5 receptor 6N51 - -
TM7 810 P 7.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 811 K 7.51x51 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 812 C 7.52x52 mGlu5 receptor 6N51 - -
TM7 813 Y 7.53x53 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 814 M 7.54x54 mGlu5 receptor 6N51 - -
TM7 815 I 7.55x55 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 816 L 7.56x56 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 817 F 7.57x57 CaS receptor 7M3G CaS receptor 7M3G
TM7 818 Y 7.58x58 CaS receptor 7M3G - -
H8 819 P 8.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 820 E 8.47x47 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 821 R 8.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 822 N 8.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 823 T 8.50x50 - - - -
H8 824 P 8.51x51 - - - -
H8 825 A 8.52x52 - - - -
H8 826 Y 8.53x53 - - - -
H8 827 F 8.54x54 - - - -
H8 828 N 8.55x55 - - - -
H8 829 S 8.56x56 - - - -
H8 830 M 8.57x57 - - - -
C-term 831 I - - - - -
C-term 832 Q - - - - -
C-term 833 G - - - - -
C-term 834 Y - - - - -
C-term 835 T - - - - -