TAS1R3 homology model

PROTEIN CLASS

Class C (Glutamate)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-06-10

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

mGlu5 receptor (sequence similarity: 16%) PDB: 6N51

TEMPLATES

7DTU (CaS receptor)
7DTW (CaS receptor)
7DTV (CaS receptor)
6N51 (mGlu5 receptor)
6FFI (mGlu5 receptor)
4OO9 (mGlu5 receptor)
7C7Q (GABAB2)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 73.9 12.5 13.6
Side-chains 10.3 19.5 70.2

Number of backbone templates: 7
Number of rotamer templates: 9

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
TM1 566 E 1.37x37 CaS receptor 7DTU - -
TM1 567 P 1.38x38 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 568 A 1.39x39 mGlu5 receptor 6N51 mGlu5 receptor 6FFI
TM1 569 V 1.40x40 mGlu5 receptor 6N51 - -
TM1 570 L 1.41x41 mGlu5 receptor 6N51 - -
TM1 571 L 1.42x42 mGlu5 receptor 6N51 - -
TM1 572 L 1.43x43 mGlu5 receptor 6N51 CaS receptor 7DTV
TM1 573 L 1.44x44 mGlu5 receptor 6N51 - -
TM1 574 L 1.45x45 mGlu5 receptor 6N51 - -
TM1 575 L 1.46x46 mGlu5 receptor 6N51 GABAB2 7C7Q
TM1 576 L 1.47x47 mGlu5 receptor 6N51 - -
TM1 577 S 1.48x48 mGlu5 receptor 6N51 GABAB1 6W2Y
TM1 578 L 1.49x49 mGlu5 receptor 6N51 mGlu5 receptor 6FFI
TM1 579 A 1.50x50 mGlu5 receptor 6N51 - -
TM1 580 L 1.51x51 mGlu5 receptor 6N51 mGlu5 receptor 6FFI
TM1 581 G 1.52x52 mGlu5 receptor 6N51 - -
TM1 582 L 1.53x53 mGlu5 receptor 6N51 GABAB1 6W2Y
TM1 583 V 1.54x54 mGlu5 receptor 6N51 - -
TM1 584 L 1.55x55 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 585 A 1.56x56 mGlu5 receptor 6N51 GABAB2 7CA5
TM1 586 A 1.57x57 mGlu5 receptor 6N51 - -
TM1 587 L 1.58x58 mGlu5 receptor 6N51 GABAB2 7C7Q
TM1 588 G 1.59x59 mGlu5 receptor 6N51 CaS receptor 7DTU
TM1 589 L 1.60x60 mGlu5 receptor 6N51 - -
TM1 590 F 1.61x61 mGlu5 receptor 6N51 mGlu5 receptor 6FFI
TM1 591 V 1.62x62 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM1 592 H 1.63x63 CaS receptor 7DTU - -
TM1 593 H 1.64x64 CaS receptor 7DTU - -
ICL1 594 R - - - - -
ICL1 595 D - mGlu5 receptor 6FFI mGlu5 receptor 6FFI
ICL1 596 S 12.47x47 mGlu5 receptor 6FFI - -
ICL1 597 P 12.48x48 mGlu5 receptor 6FFI mGlu5 receptor 6FFI
ICL1 598 L 12.49x49 mGlu5 receptor 6FFI GABAB2 7C7Q
ICL1 599 V 12.50x50 mGlu5 receptor 6FFI mGlu5 receptor 6FFI
ICL1 600 Q 12.51x51 mGlu5 receptor 6FFI - -
ICL1 601 A 12.52x52 mGlu5 receptor 6FFI - -
ICL1 602 S 12.53x53 - - - -
TM2 603 G 2.35x35 mGlu5 receptor 6N51 - -
TM2 604 G 2.36x36 mGlu5 receptor 6N51 - -
TM2 605 P 2.37x37 mGlu5 receptor 6N51 - -
TM2 606 L 2.38x38 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 607 A 2.39x39 mGlu5 receptor 6N51 - -
TM2 608 C 2.40x40 mGlu5 receptor 6N51 - -
TM2 609 F 2.41x41 mGlu5 receptor 6N51 - -
TM2 610 G 2.42x42 mGlu5 receptor 6N51 - -
TM2 611 L 2.43x43 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 612 V 2.44x44 mGlu5 receptor 6N51 - -
TM2 613 C 2.45x45 mGlu5 receptor 6N51 - -
TM2 614 L 2.46x46 mGlu5 receptor 6N51 - -
TM2 615 G 2.47x47 mGlu5 receptor 6N51 - -
TM2 616 L 2.48x48 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 617 V 2.49x49 mGlu5 receptor 6N51 - -
TM2 618 C 2.50x50 mGlu5 receptor 6N51 - -
TM2 619 L 2.51x51 mGlu5 receptor 6N51 mGlu5 receptor 6FFI
TM2 620 S 2.52x52 mGlu5 receptor 6N51 GABAB2 7C7Q
TM2 621 V 2.53x53 mGlu5 receptor 6N51 GABAB1 6W2Y
TM2 622 L 2.54x54 mGlu5 receptor 6N51 - -
TM2 623 L 2.55x55 mGlu5 receptor 6N51 GABAB2 7C7Q
TM2 624 F 2.56x56 CaS receptor 7DTW GABAB2 7C7Q
TM2 625 P 2.57x57 CaS receptor 7DTW - -
ECL1 626 G - - - - -
ECL1 627 Q - CaS receptor 7DTW - -
ECL1 628 P - - - - -
TM3 629 S 3.26x25 mGlu5 receptor 6N51 - -
TM3 630 P 3.27x26 mGlu5 receptor 6N51 GABAB1 6W2Y
TM3 631 A 3.28x27 mGlu5 receptor 6N51 - -
TM3 632 R 3.29x28 mGlu5 receptor 6N51 - -
TM3 633 C 3.30x29 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 634 L 3.31x30 mGlu5 receptor 6N51 - -
TM3 635 A 3.32x31 mGlu5 receptor 6N51 GABAB1 6W2Y
TM3 636 Q 3.33x33 mGlu5 receptor 6N51 - -
TM3 637 Q 3.34x34 mGlu5 receptor 6N51 - -
TM3 638 P 3.35x35 mGlu5 receptor 6N51 CaS receptor 7DTV
TM3 639 L 3.36x36 mGlu5 receptor 6N51 GABAB2 7C7Q
TM3 640 S 3.37x37 mGlu5 receptor 6N51 - -
TM3 641 H 3.38x38 mGlu5 receptor 6N51 - -
TM3 642 L 3.39x39 mGlu5 receptor 6N51 - -
TM3 643 P 3.40x40 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 644 L 3.41x41 mGlu5 receptor 6N51 - -
TM3 645 T 3.42x42 mGlu5 receptor 6N51 GABAB2 7C7Q
TM3 646 G 3.43x43 mGlu5 receptor 6N51 GABAB1 6W2Y
TM3 647 C 3.44x44 mGlu5 receptor 6N51 - -
TM3 648 L 3.45x45 mGlu5 receptor 6N51 - -
TM3 649 S 3.46x46 mGlu5 receptor 6N51 GABAB1 6W2Y
TM3 650 T 3.47x47 mGlu5 receptor 6N51 - -
TM3 651 L 3.48x48 mGlu5 receptor 6N51 - -
TM3 652 F 3.49x49 mGlu5 receptor 6N51 - -
TM3 653 L 3.50x50 mGlu5 receptor 6N51 - -
TM3 654 Q 3.51x51 mGlu5 receptor 6N51 - -
TM3 655 A 3.52x52 mGlu5 receptor 6N51 - -
TM3 656 A 3.53x53 mGlu5 receptor 6N51 - -
TM3 657 E 3.54x54 mGlu5 receptor 6N51 - -
TM3 658 I 3.55x55 mGlu5 receptor 6N51 - -
TM3 659 F 3.56x56 mGlu5 receptor 6N51 - -
TM3 660 V 3.57x57 mGlu5 receptor 6N51 - -
TM3 661 E 3.58x58 mGlu5 receptor 6N51 - -
TM3 662 S 3.59x59 GABAB2 7C7Q - -
ICL2 663 E - - - - -
ICL2 664 L - - - - -
ICL2 665 P - - - - -
ICL2 666 L - - - - -
ICL2 667 S - - - - -
ICL2 668 W - - - - -
ICL2 669 A - - - - -
ICL2 670 D - - - - -
ICL2 671 R - - - - -
ICL2 672 L - - - - -
ICL2 673 S - - - - -
ICL2 674 G - - - - -
ICL2 675 C - - - - -
ICL2 676 L - - - - -
TM4 677 R 4.28x28 mGlu5 receptor 6N51 - -
TM4 678 G 4.29x29 mGlu5 receptor 6N51 - -
TM4 679 P 4.30x30 mGlu5 receptor 6N51 - -
TM4 680 W 4.31x31 mGlu5 receptor 6N51 - -
TM4 681 A 4.32x32 mGlu5 receptor 6N51 - -
TM4 682 W 4.33x33 mGlu5 receptor 6N51 - -
TM4 683 L 4.34x34 mGlu5 receptor 6N51 - -
TM4 684 V 4.35x35 mGlu5 receptor 6N51 - -
TM4 685 V 4.36x36 mGlu5 receptor 6N51 GABAB2 7C7Q
TM4 686 L 4.37x37 mGlu5 receptor 6N51 - -
TM4 687 L 4.38x38 mGlu5 receptor 6N51 GABAB1 6W2Y
TM4 688 A 4.39x39 mGlu5 receptor 6N51 - -
TM4 689 M 4.40x40 mGlu5 receptor 6N51 - -
TM4 690 L 4.41x41 mGlu5 receptor 6N51 GABAB2 7C7Q
TM4 691 V 4.42x42 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM4 692 E 4.43x43 mGlu5 receptor 6N51 - -
TM4 693 V 4.44x44 mGlu5 receptor 6N51 - -
TM4 694 A 4.45x45 mGlu5 receptor 6N51 - -
TM4 695 L 4.46x46 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM4 696 C 4.47x47 mGlu5 receptor 6N51 - -
TM4 697 T 4.48x48 mGlu5 receptor 6N51 - -
TM4 698 W 4.49x49 mGlu5 receptor 6N51 - -
TM4 699 Y 4.50x50 mGlu5 receptor 6N51 - -
TM4 700 L 4.51x51 mGlu5 receptor 6N51 - -
TM4 701 V 4.52x52 mGlu5 receptor 6N51 - -
TM4 702 A 4.53x53 mGlu5 receptor 6N51 - -
TM4 703 F 4.54x54 mGlu5 receptor 6N51 - -
ECL2 704 P - mGlu5 receptor 6N51 mGlu5 receptor 6N51
ECL2 705 P - mGlu5 receptor 6N51 mGlu5 receptor 6N51
ECL2 706 E - mGlu5 receptor 6N51 - -
ECL2 707 V - mGlu5 receptor 6N51 - -
ECL2 708 V - mGlu5 receptor 6N51 - -
ECL2 709 T - mGlu5 receptor 6N51 - -
ECL2 710 D - mGlu5 receptor 6N51 mGlu5 receptor 6N51
ECL2 711 W - mGlu5 receptor 6N51 - -
ECL2 712 H - mGlu5 receptor 6N51 - -
ECL2 713 M - mGlu5 receptor 6N51 - -
ECL2 714 L - mGlu5 receptor 6N51 - -
ECL2 715 P - mGlu5 receptor 6N51 - -
ECL2 716 T - mGlu5 receptor 6N51 - -
ECL2 717 E - mGlu5 receptor 6N51 - -
ECL2 718 A - mGlu5 receptor 6N51 - -
ECL2 719 L - mGlu5 receptor 6N51 mGlu5 receptor 6N51
ECL2 720 V - mGlu5 receptor 6N51 - -
ECL2 721 H - - - - -
ECL2 722 C 45.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
ECL2 723 R 45.51x51 mGlu5 receptor 6N51 - -
ECL2 724 T 45.52x52 mGlu5 receptor 6N51 mGlu5 receptor 6N51
ECL2 725 R - - - - -
ECL2 726 S - - - - -
TM5 727 W 5.37x37 mGlu5 receptor 6N51 - -
TM5 728 V 5.38x38 mGlu5 receptor 6N51 - -
TM5 729 S 5.39x39 mGlu5 receptor 6N51 - -
TM5 730 F 5.40x40 mGlu5 receptor 6N51 - -
TM5 731 G 5.41x41 mGlu5 receptor 6N51 GABAB2 7CA5
TM5 732 L 5.42x42 mGlu5 receptor 6N51 - -
TM5 733 A 5.43x43 mGlu5 receptor 6N51 - -
TM5 734 H 5.44x44 mGlu5 receptor 6N51 - -
TM5 735 A 5.45x45 mGlu5 receptor 6N51 GABAB2 7CA5
TM5 736 T 5.46x46 mGlu5 receptor 6N51 - -
TM5 737 N 5.47x47 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 738 A 5.48x48 mGlu5 receptor 6N51 - -
TM5 739 T 5.49x49 mGlu5 receptor 6N51 - -
TM5 740 L 5.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 741 A 5.51x51 mGlu5 receptor 6N51 CaS receptor 7DTU
TM5 742 F 5.52x52 mGlu5 receptor 6N51 - -
TM5 743 L 5.53x53 mGlu5 receptor 6N51 GABAB1 6W2Y
TM5 744 C 5.54x54 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 745 F 5.55x55 mGlu5 receptor 6N51 - -
TM5 746 L 5.56x56 mGlu5 receptor 6N51 - -
TM5 747 G 5.57x57 mGlu5 receptor 6N51 - -
TM5 748 T 5.58x58 mGlu5 receptor 6N51 - -
TM5 749 F 5.59x59 CaS receptor 7DTW mGlu5 receptor 6FFI
TM5 750 L 5.60x60 CaS receptor 7DTW - -
TM5 751 V 5.61x61 CaS receptor 7DTW - -
TM5 752 R 5.62x62 CaS receptor 7DTW GABAB2 7C7Q
TM5 753 S 5.63x63 CaS receptor 7DTW - -
TM5 754 Q 5.64x64 CaS receptor 7DTW - -
ICL3 755 P - - - - -
ICL3 756 G - CaS receptor 7DTW - -
ICL3 757 C - CaS receptor 7DTW - -
ICL3 758 Y - - - - -
TM6 759 N 6.34x34 CaS receptor 7DTU mGlu5 receptor 6N51
TM6 760 R 6.35x35 mGlu5 receptor 6N51 - -
TM6 761 A 6.36x36 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 762 R 6.37x37 mGlu5 receptor 6N51 - -
TM6 763 G 6.38x38 mGlu5 receptor 6N51 - -
TM6 764 L 6.39x39 mGlu5 receptor 6N51 - -
TM6 765 T 6.40x40 mGlu5 receptor 6N51 - -
TM6 766 F 6.41x41 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 767 A 6.42x42 mGlu5 receptor 6N51 GABAB1 6W2Y
TM6 768 M 6.43x43 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 769 L 6.44x44 mGlu5 receptor 6N51 - -
TM6 770 A 6.45x45 mGlu5 receptor 6N51 - -
TM6 771 Y 6.46x46 mGlu5 receptor 6N51 - -
TM6 772 F 6.47x47 mGlu5 receptor 6N51 - -
TM6 773 I 6.48x48 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 774 T 6.49x49 mGlu5 receptor 6N51 - -
TM6 775 W 6.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 776 V 6.51x51 mGlu5 receptor 6N51 - -
TM6 777 S 6.52x52 mGlu5 receptor 6N51 - -
TM6 778 F 6.53x53 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 779 V 6.54x54 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 780 P 6.55x55 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 781 L 6.56x56 mGlu5 receptor 6N51 - -
TM6 782 L 6.57x57 mGlu5 receptor 6N51 - -
TM6 783 A 6.58x58 mGlu5 receptor 6N51 CaS receptor 7DTU
TM6 784 N 6.59x59 mGlu5 receptor 6N51 - -
TM6 785 V 6.60x60 CaS receptor 7DTV - -
ECL3 786 Q - - - - -
TM7 787 V 7.25x26 CaS receptor 7DTU - -
TM7 788 V 7.26x27 CaS receptor 7DTU - -
TM7 789 L 7.27x28 CaS receptor 7DTU - -
TM7 790 R 7.28x29 CaS receptor 7DTU - -
TM7 791 P 7.29x30 mGlu5 receptor 6N51 - -
TM7 792 A 7.30x31 mGlu5 receptor 6N51 CaS receptor 7DTU
TM7 793 V 7.31x32 mGlu5 receptor 6N51 CaS receptor 7DTV
TM7 794 Q 7.32x33 mGlu5 receptor 6N51 - -
TM7 795 M 7.33x34 mGlu5 receptor 6N51 - -
TM7 796 G 7.34x35 mGlu5 receptor 6N51 - -
TM7 797 A 7.35x36 mGlu5 receptor 6N51 CaS receptor 7DTU
TM7 798 L 7.36x37 mGlu5 receptor 6N51 - -
TM7 799 L 7.37x38 mGlu5 receptor 6N51 CaS receptor 7DTV
TM7 800 L 7.38x39 mGlu5 receptor 6N51 mGlu5 receptor 6FFI
TM7 801 C 7.39x40 mGlu5 receptor 6N51 GABAB2 7C7Q
TM7 802 V 7.40x41 mGlu5 receptor 6N51 mGlu1 receptor 4OR2
TM7 803 L 7.41x42 mGlu5 receptor 6N51 - -
TM7 804 G 7.42x43 mGlu5 receptor 6N51 CaS receptor 7DTU
TM7 805 I 7.43x44 mGlu5 receptor 6N51 - -
TM7 806 L 7.44x45 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 807 A 7.45x46 mGlu5 receptor 6N51 CaS receptor 7DTU
TM7 808 A 7.46x47 mGlu5 receptor 6N51 - -
TM7 809 F 7.47x471 mGlu5 receptor 6N51 - -
TM7 810 H 7.48x48 mGlu5 receptor 6N51 - -
TM7 811 L 7.49x49 mGlu5 receptor 6N51 - -
TM7 812 P 7.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 813 R 7.51x51 mGlu5 receptor 6N51 - -
TM7 814 C 7.52x52 mGlu5 receptor 6N51 - -
TM7 815 Y 7.53x53 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 816 L 7.54x54 mGlu5 receptor 6N51 - -
TM7 817 L 7.55x55 mGlu5 receptor 6N51 GABAB2 7C7Q
TM7 818 M 7.56x56 mGlu5 receptor 6N51 - -
TM7 819 R 7.57x57 mGlu5 receptor 4OO9 - -
TM7 820 Q 7.58x58 mGlu5 receptor 4OO9 - -
H8 821 P 8.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 822 G 8.47x47 mGlu5 receptor 4OO9 - -
H8 823 L 8.48x48 mGlu5 receptor 4OO9 - -
H8 824 N 8.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 825 T 8.50x50 - - - -
H8 826 P 8.51x51 - - - -
H8 827 E 8.52x52 - - - -
H8 828 F 8.53x53 - - - -
H8 829 F 8.54x54 - - - -
H8 830 L 8.55x55 - - - -
H8 831 G 8.56x56 - - - -
H8 832 G 8.57x57 - - - -
C-term 833 G - - - - -
C-term 834 P - - - - -
C-term 835 G - - - - -
C-term 836 D - - - - -
C-term 837 A - - - - -