V2 receptor homology model
PROTEIN CLASS
Class A (Rhodopsin)
RECEPTOR
SPECIES
Homo sapiens
STATE
Intermediate
VERSION
2021-04-08
MODEL
TEMPLATES
5NDD (PAR2)
5WQC (OX2 receptor)
6OSA (NTS1 receptor)
6TPK (OT receptor)
6W25 (MC4 receptor)
6ME7 (MT2 receptor)
7JVQ (D1 receptor)
5WIV (D4 receptor)
None
5WQC (OX2 receptor)
6OSA (NTS1 receptor)
6TPK (OT receptor)
6W25 (MC4 receptor)
6ME7 (MT2 receptor)
7JVQ (D1 receptor)
5WIV (D4 receptor)
None
| Main template (%) | Additional templates (%) | No template - freely modelled (%) | |
|---|---|---|---|
| Backbone | 77.6 | 15.5 | 6.9 |
| Side-chains | 19.9 | 59.6 | 20.5 |
Number of backbone templates: 8
Number of rotamer templates: 48
| Segment | Seq.num. | AA | GPCRdb# | Backbone | PDB | Rotamer | PDB |
|---|---|---|---|---|---|---|---|
| N-term | 28 | P | - | PAR2 | 5NDD | PAR2 | 5NDD |
| N-term | 29 | L | - | PAR2 | 5NDD | PAR2 | 5NDD |
| N-term | 30 | D | - | PAR2 | 5NDD | PAR2 | 5NDD |
| N-term | 31 | T | - | PAR2 | 5NDD | PAR2 | 5NDD |
| N-term | 32 | R | - | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 33 | D | 1.28x28 | PAR2 | 5NDD | NTS1 receptor | 6OSA |
| TM1 | 34 | P | 1.29x29 | PAR2 | 5NDD | Rhodopsin | 1U19 |
| TM1 | 35 | L | 1.30x30 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 36 | L | 1.31x31 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM1 | 37 | A | 1.32x32 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM1 | 38 | R | 1.33x33 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM1 | 39 | A | 1.34x34 | PAR2 | 5NDD | MT2 receptor | 6ME7 |
| TM1 | 40 | E | 1.35x35 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM1 | 41 | L | 1.36x36 | PAR2 | 5NDD | D4 receptor | 5WIV |
| TM1 | 42 | A | 1.37x37 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM1 | 43 | L | 1.38x38 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM1 | 44 | L | 1.39x39 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM1 | 45 | S | 1.40x40 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM1 | 46 | I | 1.41x41 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 47 | V | 1.42x42 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 48 | F | 1.43x43 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 49 | V | 1.44x44 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 50 | A | 1.45x45 | PAR2 | 5NDD | D4 receptor | 5WIV |
| TM1 | 51 | V | 1.46x46 | PAR2 | 5NDD | D4 receptor | 5WIV |
| TM1 | 52 | A | 1.47x47 | PAR2 | 5NDD | GnRH1 receptor | 7BR3 |
| TM1 | 53 | L | 1.48x48 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM1 | 54 | S | 1.49x49 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 55 | N | 1.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 56 | G | 1.51x51 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 57 | L | 1.52x52 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM1 | 58 | V | 1.53x53 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM1 | 59 | L | 1.54x54 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 60 | A | 1.55x55 | PAR2 | 5NDD | 5-HT1B receptor | 4IAQ |
| TM1 | 61 | A | 1.56x56 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM1 | 62 | L | 1.57x57 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM1 | 63 | A | 1.58x58 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM1 | 64 | R | 1.59x59 | PAR2 | 5NDD | MT2 receptor | 6ME7 |
| TM1 | 65 | R | 1.60x60 | PAR2 | 5NDD | PAR2 | 5NDD |
| ICL1 | 66 | G | - | - | - | - | - |
| ICL1 | 67 | R | 12.48x48 | OX2 receptor | 5WQC | MT2 receptor | 6ME6 |
| ICL1 | 68 | R | 12.49x49 | OX2 receptor | 5WQC | LPA1 receptor | 4Z36 |
| ICL1 | 69 | G | 12.50x50 | OX2 receptor | 5WQC | CXCR2 | 6LFL |
| ICL1 | 70 | H | 12.51x51 | - | - | - | - |
| TM2 | 71 | W | 2.36x36 | NTS1 receptor | 6OSA | - | - |
| TM2 | 72 | A | 2.37x37 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 73 | P | 2.38x38 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 74 | I | 2.39x39 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM2 | 75 | H | 2.40x40 | PAR2 | 5NDD | NTS1 receptor | 6OSA |
| TM2 | 76 | V | 2.41x41 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM2 | 77 | F | 2.42x42 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM2 | 78 | I | 2.43x43 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM2 | 79 | G | 2.44x44 | PAR2 | 5NDD | NTS1 receptor | 6OSA |
| TM2 | 80 | H | 2.45x45 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM2 | 81 | L | 2.46x46 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 82 | C | 2.47x47 | PAR2 | 5NDD | - | - |
| TM2 | 83 | L | 2.48x48 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 84 | A | 2.49x49 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 85 | D | 2.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 86 | L | 2.51x51 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 87 | A | 2.52x52 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM2 | 88 | V | 2.53x53 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM2 | 89 | A | 2.54x54 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM2 | 90 | L | 2.55x55 | OT receptor | 6TPK | 5-HT2B receptor | 5TVN |
| TM2 | 91 | F | 2.56x551 | OT receptor | 6TPK | OT receptor | 6TPK |
| TM2 | 92 | Q | 2.57x56 | OT receptor | 6TPK | OT receptor | 6TPK |
| TM2 | 93 | V | 2.58x57 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM2 | 94 | L | 2.59x58 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM2 | 95 | P | 2.60x59 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM2 | 96 | Q | 2.61x60 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM2 | 97 | L | 2.62x61 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM2 | 98 | A | 2.63x62 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 99 | W | 2.64x63 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM2 | 100 | K | 2.65x64 | PAR2 | 5NDD | CXCR2 | 6LFL |
| TM2 | 101 | A | 2.66x65 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| ECL1 | 102 | T | 23.49x49 | OT receptor | 6TPK | OX2 receptor | 5WQC |
| ECL1 | 103 | D | 23.50x50 | OT receptor | 6TPK | - | - |
| ECL1 | 104 | R | 23.51x51 | OT receptor | 6TPK | - | - |
| ECL1 | 105 | F | 23.52x52 | OT receptor | 6TPK | CysLT2 receptor | 6RZ7 |
| TM3 | 106 | R | 3.19x19 | MC4 receptor | 6W25 | - | - |
| TM3 | 107 | G | 3.20x20 | MC4 receptor | 6W25 | - | - |
| TM3 | 108 | P | 3.21x21 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM3 | 109 | D | 3.22x22 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM3 | 110 | A | 3.23x23 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 111 | L | 3.24x24 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 112 | C | 3.25x25 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 113 | R | 3.26x26 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM3 | 114 | A | 3.27x27 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM3 | 115 | V | 3.28x28 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM3 | 116 | K | 3.29x29 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM3 | 117 | Y | 3.30x30 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM3 | 118 | L | 3.31x31 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM3 | 119 | Q | 3.32x32 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM3 | 120 | M | 3.33x33 | PAR2 | 5NDD | - | - |
| TM3 | 121 | V | 3.34x34 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM3 | 122 | G | 3.35x35 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM3 | 123 | M | 3.36x36 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 124 | Y | 3.37x37 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 125 | A | 3.38x38 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM3 | 126 | S | 3.39x39 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 127 | S | 3.40x40 | PAR2 | 5NDD | - | - |
| TM3 | 128 | Y | 3.41x41 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM3 | 129 | M | 3.42x42 | PAR2 | 5NDD | GnRH1 receptor | 7BR3 |
| TM3 | 130 | I | 3.43x43 | PAR2 | 5NDD | MT2 receptor | 6ME7 |
| TM3 | 131 | L | 3.44x44 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM3 | 132 | A | 3.45x45 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM3 | 133 | M | 3.46x46 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM3 | 134 | T | 3.47x47 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM3 | 135 | L | 3.48x48 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM3 | 136 | D | 3.49x49 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM3 | 137 | R | 3.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 138 | H | 3.51x51 | PAR2 | 5NDD | LPA1 receptor | 4Z35 |
| TM3 | 139 | R | 3.52x52 | PAR2 | 5NDD | H1 receptor | 3RZE |
| TM3 | 140 | A | 3.53x53 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM3 | 141 | I | 3.54x54 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 142 | C | 3.55x55 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM3 | 143 | R | 3.56x56 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| ICL2 | 144 | P | 34.50x50 | - | - | - | - |
| ICL2 | 145 | M | 34.51x51 | MT2 receptor | 6ME7 | MT2 receptor | 6ME7 |
| ICL2 | 146 | L | 34.52x52 | MT2 receptor | 6ME7 | OX1 receptor | 6TO7 |
| ICL2 | 147 | A | 34.53x53 | MT2 receptor | 6ME7 | NTS1 receptor | 6OSA |
| ICL2 | 148 | Y | 34.54x54 | MT2 receptor | 6ME7 | - | - |
| ICL2 | 149 | R | 34.55x55 | MT2 receptor | 6ME7 | MT2 receptor | 6ME6 |
| ICL2 | 150 | H | 34.56x56 | MT2 receptor | 6ME7 | EP3 receptor | 6M9T |
| ICL2 | 151 | G | 34.57x57 | - | - | - | - |
| TM4 | 152 | S | 4.38x38 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM4 | 153 | G | 4.39x39 | PAR2 | 5NDD | A2A receptor | 4UHR |
| TM4 | 154 | A | 4.40x40 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM4 | 155 | H | 4.41x41 | PAR2 | 5NDD | MT2 receptor | 6ME7 |
| TM4 | 156 | W | 4.42x42 | PAR2 | 5NDD | - | - |
| TM4 | 157 | N | 4.43x43 | PAR2 | 5NDD | - | - |
| TM4 | 158 | R | 4.44x44 | PAR2 | 5NDD | BLT1 receptor | 7K15 |
| TM4 | 159 | P | 4.45x45 | PAR2 | 5NDD | - | - |
| TM4 | 160 | V | 4.46x46 | PAR2 | 5NDD | TP receptor | 6IIV |
| TM4 | 161 | L | 4.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 162 | V | 4.48x48 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM4 | 163 | A | 4.49x49 | PAR2 | 5NDD | GnRH1 receptor | 7BR3 |
| TM4 | 164 | W | 4.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 165 | A | 4.51x51 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM4 | 166 | F | 4.52x52 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM4 | 167 | S | 4.53x53 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM4 | 168 | L | 4.54x54 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 169 | L | 4.55x55 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 170 | L | 4.56x56 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM4 | 171 | S | 4.57x57 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM4 | 172 | L | 4.58x59 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM4 | 173 | P | 4.59x60 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 174 | Q | 4.60x61 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM4 | 175 | L | 4.61x62 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM4 | 176 | F | 4.62x63 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM4 | 177 | I | 4.63x64 | OT receptor | 6TPK | OT receptor | 6TPK |
| TM4 | 178 | F | 4.64x65 | OT receptor | 6TPK | OT receptor | 6TPK |
| ECL2 | 179 | A | - | PAR2 | 5NDD | - | - |
| ECL2 | 180 | Q | - | PAR2 | 5NDD | - | - |
| ECL2 | 181 | R | - | PAR2 | 5NDD | - | - |
| ECL2 | 182 | N | - | PAR2 | 5NDD | - | - |
| ECL2 | 183 | V | - | PAR2 | 5NDD | - | - |
| ECL2 | 184 | E | - | PAR2 | 5NDD | - | - |
| ECL2 | 185 | G | - | PAR2 | 5NDD | - | - |
| ECL2 | 186 | G | - | PAR2 | 5NDD | - | - |
| ECL2 | 187 | S | - | PAR2 | 5NDD | - | - |
| ECL2 | 188 | G | - | PAR2 | 5NDD | - | - |
| ECL2 | 189 | V | - | PAR2 | 5NDD | - | - |
| ECL2 | 190 | T | - | PAR2 | 5NDD | - | - |
| ECL2 | 191 | D | - | PAR2 | 5NDD | - | - |
| ECL2 | 192 | C | 45.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| ECL2 | 193 | W | 45.51x51 | PAR2 | 5NDD | - | - |
| ECL2 | 194 | A | 45.52x52 | PAR2 | 5NDD | - | - |
| ECL2 | 195 | C | - | OT receptor | 6TPK | OT receptor | 6TPK |
| ECL2 | 196 | F | - | - | - | - | - |
| ECL2 | 197 | A | - | OT receptor | 6TPK | OT receptor | 6TPK |
| ECL2 | 198 | E | - | OT receptor | 6TPK | - | - |
| ECL2 | 199 | P | - | OT receptor | 6TPK | - | - |
| TM5 | 200 | W | 5.33x34 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM5 | 201 | G | 5.34x35 | PAR2 | 5NDD | TP receptor | 6IIV |
| TM5 | 202 | R | 5.35x36 | PAR2 | 5NDD | BLT1 receptor | 7K15 |
| TM5 | 203 | R | 5.36x37 | PAR2 | 5NDD | D4 receptor | 5WIV |
| TM5 | 204 | T | 5.37x38 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM5 | 205 | Y | 5.38x39 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 206 | V | 5.39x40 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM5 | 207 | T | 5.40x41 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM5 | 208 | W | 5.41x42 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM5 | 209 | I | 5.42x43 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM5 | 210 | A | 5.43x44 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 211 | L | 5.44x45 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM5 | 212 | M | 5.45x46 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM5 | 213 | V | 5.46x461 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 214 | F | 5.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 215 | V | 5.48x48 | PAR2 | 5NDD | δ receptor | 4N6H |
| TM5 | 216 | A | 5.49x49 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM5 | 217 | P | 5.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 218 | T | 5.51x51 | PAR2 | 5NDD | 5-HT1B receptor | 4IAQ |
| TM5 | 219 | L | 5.52x52 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM5 | 220 | G | 5.53x53 | PAR2 | 5NDD | CB2 receptor | 5ZTY |
| TM5 | 221 | I | 5.54x54 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM5 | 222 | A | 5.55x55 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 223 | A | 5.56x56 | PAR2 | 5NDD | BLT1 receptor | 7K15 |
| TM5 | 224 | C | 5.57x57 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM5 | 225 | Q | 5.58x58 | PAR2 | 5NDD | - | - |
| TM5 | 226 | V | 5.59x59 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 227 | L | 5.60x60 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 228 | I | 5.61x61 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM5 | 229 | F | 5.62x62 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM5 | 230 | R | 5.63x63 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 231 | E | 5.64x64 | PAR2 | 5NDD | P2Y12 receptor | 4PXZ |
| TM5 | 232 | I | 5.65x65 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM5 | 233 | H | 5.66x66 | D1 receptor | 7JVQ | CCR7 | 6QZH |
| TM5 | 234 | A | 5.67x67 | D1 receptor | 7JVQ | NK1 receptor | 6HLP |
| TM5 | 235 | S | 5.68x68 | D1 receptor | 7JVQ | P2Y12 receptor | 4NTJ |
| TM5 | 236 | L | 5.69x69 | D1 receptor | 7JVQ | GnRH1 receptor | 7BR3 |
| TM5 | 237 | V | 5.70x70 | D1 receptor | 7JVQ | P2Y12 receptor | 4NTJ |
| TM5 | 238 | P | 5.71x71 | D1 receptor | 7JVQ | - | - |
| TM5 | 239 | G | 5.72x72 | D1 receptor | 7JVQ | - | - |
| TM5 | 240 | P | 5.73x73 | D1 receptor | 7JVQ | - | - |
| TM5 | 241 | S | 5.74x74 | D1 receptor | 7JVQ | A2A receptor | 4UHR |
| TM5 | 242 | E | 5.75x75 | D1 receptor | 7JVQ | - | - |
| TM5 | 243 | R | 5.76x76 | D1 receptor | 7JVQ | GPR52 | 6LI3 |
| ICL3 | 244 | P | - | - | - | - | - |
| ICL3 | 245 | G | - | - | - | - | - |
| ICL3 | 246 | G | - | - | - | - | - |
| ICL3 | 247 | R | - | - | - | - | - |
| ICL3 | 248 | R | - | - | - | - | - |
| ICL3 | 255 | S | - | - | - | - | - |
| ICL3 | 256 | P | - | - | - | - | - |
| ICL3 | 257 | G | - | - | - | - | - |
| ICL3 | 258 | E | - | - | - | - | - |
| ICL3 | 259 | G | - | - | - | - | - |
| TM6 | 260 | A | 6.24x24 | NTS1 receptor | 6OSA | Rhodopsin | 4X1H |
| TM6 | 261 | H | 6.25x25 | NTS1 receptor | 6OSA | Y2 receptor | 7DDZ |
| TM6 | 262 | V | 6.26x26 | NTS1 receptor | 6OSA | M5 receptor | 6OL9 |
| TM6 | 263 | S | 6.27x27 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 264 | A | 6.28x28 | PAR2 | 5NDD | 5-HT1B receptor | 4IAQ |
| TM6 | 265 | A | 6.29x29 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM6 | 266 | V | 6.30x30 | PAR2 | 5NDD | - | - |
| TM6 | 267 | A | 6.31x31 | PAR2 | 5NDD | - | - |
| TM6 | 268 | K | 6.32x32 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 269 | T | 6.33x33 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM6 | 270 | V | 6.34x34 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM6 | 271 | R | 6.35x35 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM6 | 272 | M | 6.36x36 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM6 | 273 | T | 6.37x37 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM6 | 274 | L | 6.38x38 | PAR2 | 5NDD | NOP receptor | 5DHG |
| TM6 | 275 | V | 6.39x39 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 276 | I | 6.40x40 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM6 | 277 | V | 6.41x41 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 278 | V | 6.42x42 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM6 | 279 | V | 6.43x43 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM6 | 280 | Y | 6.44x44 | PAR2 | 5NDD | CCR5 | 4MBS |
| TM6 | 281 | V | 6.45x45 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM6 | 282 | L | 6.46x46 | OT receptor | 6TPK | PAR2 | 5NDD |
| TM6 | 283 | C | 6.47x47 | OT receptor | 6TPK | OT receptor | 6TPK |
| TM6 | 284 | W | 6.48x48 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM6 | 285 | A | 6.49x49 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM6 | 286 | P | 6.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 287 | F | 6.51x51 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM6 | 288 | F | 6.52x52 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM6 | 289 | L | 6.53x53 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 290 | V | 6.54x54 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM6 | 291 | Q | 6.55x55 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM6 | 292 | L | 6.56x56 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM6 | 293 | W | 6.57x57 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM6 | 294 | A | 6.58x58 | PAR2 | 5NDD | 5-HT2A receptor | 6A94 |
| TM6 | 295 | A | 6.59x59 | PAR2 | 5NDD | MT2 receptor | 6ME7 |
| TM6 | 296 | W | 6.60x60 | PAR2 | 5NDD | Y1 receptor | 5ZBH |
| TM6 | 297 | D | 6.61x61 | PAR2 | 5NDD | Y2 receptor | 7DDZ |
| ECL3 | 298 | P | - | - | - | - | - |
| ECL3 | 299 | E | - | D4 receptor | 5WIV | - | - |
| ECL3 | 300 | A | - | D4 receptor | 5WIV | - | - |
| ECL3 | 301 | P | - | D4 receptor | 5WIV | - | - |
| ECL3 | 302 | L | - | - | - | - | - |
| TM7 | 303 | E | 7.31x30 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM7 | 304 | G | 7.32x31 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM7 | 305 | A | 7.33x32 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 306 | P | 7.34x33 | PAR2 | 5NDD | EP4 receptor | 5YWY |
| TM7 | 307 | F | 7.35x34 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM7 | 308 | V | 7.36x35 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM7 | 309 | L | 7.37x36 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM7 | 310 | L | 7.38x37 | PAR2 | 5NDD | BLT1 receptor | 7K15 |
| TM7 | 311 | M | 7.39x38 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM7 | 312 | L | 7.40x39 | PAR2 | 5NDD | OT receptor | 6TPK |
| TM7 | 313 | L | 7.41x40 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 314 | A | 7.42x41 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM7 | 315 | S | 7.43x42 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM7 | 316 | L | 7.44x43 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 317 | N | 7.45x45 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 318 | S | 7.46x46 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 319 | C | 7.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 320 | T | 7.48x48 | PAR2 | 5NDD | S1P1 receptor | 3V2Y |
| TM7 | 321 | N | 7.49x49 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM7 | 322 | P | 7.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 323 | W | 7.51x51 | PAR2 | 5NDD | TP receptor | 6IIV |
| TM7 | 324 | I | 7.52x52 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM7 | 325 | Y | 7.53x53 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 326 | A | 7.54x54 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM7 | 327 | S | 7.55x55 | PAR2 | 5NDD | - | - |
| TM7 | 328 | F | 7.56x56 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| H8 | 329 | S | 8.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| H8 | 330 | S | 8.48x48 | PAR2 | 5NDD | GPR52 | 6LI1 |
| H8 | 331 | S | 8.49x49 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| H8 | 332 | V | 8.50x50 | PAR2 | 5NDD | TP receptor | 6IIV |
| H8 | 333 | S | 8.51x51 | PAR2 | 5NDD | LPA1 receptor | 4Z35 |
| H8 | 334 | S | 8.52x52 | PAR2 | 5NDD | 5-HT2A receptor | 6A94 |
| H8 | 335 | E | 8.53x53 | PAR2 | 5NDD | MT2 receptor | 6ME7 |
| H8 | 336 | L | 8.54x54 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| H8 | 337 | R | 8.55x55 | PAR2 | 5NDD | GPR52 | 6LI1 |
| H8 | 338 | S | 8.56x56 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| H8 | 339 | L | 8.57x57 | PAR2 | 5NDD | GPR52 | 6LI1 |
| H8 | 340 | L | 8.58x58 | PAR2 | 5NDD | PAR2 | 5NDD |
| H8 | 341 | C | 8.59x59 | MT2 receptor | 6ME7 | MC4 receptor | 6W25 |
| H8 | 342 | C | 8.60x60 | MT2 receptor | 6ME7 | MC4 receptor | 6W25 |
| H8 | 343 | A | 8.61x61 | MT2 receptor | 6ME7 | - | - |
| H8 | 344 | R | 8.62x62 | MT2 receptor | 6ME7 | - | - |
| H8 | 345 | G | 8.63x63 | MT2 receptor | 6ME7 | - | - |
| C-term | 346 | R | - | - | - | - | - |
| C-term | 347 | T | - | - | - | - | - |
| C-term | 348 | P | - | - | - | - | - |
| C-term | 349 | P | - | - | - | - | - |
| C-term | 350 | S | - | - | - | - | - |