V2 receptor homology model
PROTEIN CLASS
Class A (Rhodopsin)
RECEPTOR
SPECIES
Homo sapiens
STATE
Intermediate
VERSION
2021-11-02
MODEL
TEMPLATES
5NDD (PAR2)
7KH0 (V2 receptor)
6ME7 (MT2 receptor)
7EZM (CCK1 receptor)
3SN6 (β2-adrenoceptor)
None
7KH0 (V2 receptor)
6ME7 (MT2 receptor)
7EZM (CCK1 receptor)
3SN6 (β2-adrenoceptor)
None
| Main template (%) | Additional templates (%) | No template - freely modelled (%) | |
|---|---|---|---|
| Backbone | 77.6 | 14.8 | 7.6 |
| Side-chains | 19.6 | 65.3 | 15.1 |
Number of backbone templates: 5
Number of rotamer templates: 29
| Segment | Seq.num. | AA | GPCRdb# | Backbone | PDB | Rotamer | PDB |
|---|---|---|---|---|---|---|---|
| N-term | 28 | P | - | PAR2 | 5NDD | PAR2 | 5NDD |
| N-term | 29 | L | - | PAR2 | 5NDD | PAR2 | 5NDD |
| N-term | 30 | D | - | PAR2 | 5NDD | PAR2 | 5NDD |
| N-term | 31 | T | - | PAR2 | 5NDD | PAR2 | 5NDD |
| N-term | 32 | R | - | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 33 | D | 1.28x28 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM1 | 34 | P | 1.29x29 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM1 | 35 | L | 1.30x30 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 36 | L | 1.31x31 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM1 | 37 | A | 1.32x32 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM1 | 38 | R | 1.33x33 | PAR2 | 5NDD | V2 receptor | 7DW9 |
| TM1 | 39 | A | 1.34x34 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM1 | 40 | E | 1.35x35 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM1 | 41 | L | 1.36x36 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM1 | 42 | A | 1.37x37 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM1 | 43 | L | 1.38x38 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM1 | 44 | L | 1.39x39 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM1 | 45 | S | 1.40x40 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM1 | 46 | I | 1.41x41 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 47 | V | 1.42x42 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 48 | F | 1.43x43 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 49 | V | 1.44x44 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 50 | A | 1.45x45 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM1 | 51 | V | 1.46x46 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM1 | 52 | A | 1.47x47 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM1 | 53 | L | 1.48x48 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM1 | 54 | S | 1.49x49 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 55 | N | 1.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 56 | G | 1.51x51 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 57 | L | 1.52x52 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM1 | 58 | V | 1.53x53 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM1 | 59 | L | 1.54x54 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 60 | A | 1.55x55 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM1 | 61 | A | 1.56x56 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM1 | 62 | L | 1.57x57 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM1 | 63 | A | 1.58x58 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM1 | 64 | R | 1.59x59 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM1 | 65 | R | 1.60x60 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM1 | 66 | G | 1.61x61 | V2 receptor | 7KH0 | V2 receptor | 7KH0 |
| TM1 | 67 | R | 1.62x62 | V2 receptor | 7KH0 | V2 receptor | 7KH0 |
| TM1 | 68 | R | 1.63x63 | V2 receptor | 7KH0 | V2 receptor | 7KH0 |
| TM1 | 69 | G | 1.64x64 | V2 receptor | 7KH0 | V2 receptor | 7KH0 |
| ICL1 | 70 | H | - | - | - | - | - |
| ICL1 | 71 | W | - | - | - | - | - |
| TM2 | 72 | A | 2.37x37 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 73 | P | 2.38x38 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 74 | I | 2.39x39 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM2 | 75 | H | 2.40x40 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM2 | 76 | V | 2.41x41 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM2 | 77 | F | 2.42x42 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM2 | 78 | I | 2.43x43 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM2 | 79 | G | 2.44x44 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM2 | 80 | H | 2.45x45 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM2 | 81 | L | 2.46x46 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 82 | C | 2.47x47 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM2 | 83 | L | 2.48x48 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 84 | A | 2.49x49 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 85 | D | 2.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 86 | L | 2.51x51 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 87 | A | 2.52x52 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM2 | 88 | V | 2.53x53 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM2 | 89 | A | 2.54x54 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM2 | 90 | L | 2.55x55 | V2 receptor | 7KH0 | V2 receptor | 7KH0 |
| TM2 | 91 | F | 2.56x551 | V2 receptor | 7KH0 | V2 receptor | 7KH0 |
| TM2 | 92 | Q | 2.57x56 | V2 receptor | 7KH0 | V2 receptor | 7KH0 |
| TM2 | 93 | V | 2.58x57 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM2 | 94 | L | 2.59x58 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM2 | 95 | P | 2.60x59 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM2 | 96 | Q | 2.61x60 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM2 | 97 | L | 2.62x61 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM2 | 98 | A | 2.63x62 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM2 | 99 | W | 2.64x63 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM2 | 100 | K | 2.65x64 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM2 | 101 | A | 2.66x65 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM2 | 102 | T | 2.67x66 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM2 | 103 | D | 2.68x67 | V2 receptor | 7KH0 | V2 receptor | 7KH0 |
| ECL1 | 104 | R | 23.49x49 | - | - | - | - |
| ECL1 | 105 | F | 23.50x50 | MT2 receptor | 6ME7 | V2 receptor | 7KH0 |
| ECL1 | 106 | R | 23.51x51 | MT2 receptor | 6ME7 | V2 receptor | 7DW9 |
| ECL1 | 107 | G | 23.52x52 | - | - | - | - |
| TM3 | 108 | P | 3.21x21 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM3 | 109 | D | 3.22x22 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM3 | 110 | A | 3.23x23 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 111 | L | 3.24x24 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 112 | C | 3.25x25 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 113 | R | 3.26x26 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM3 | 114 | A | 3.27x27 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM3 | 115 | V | 3.28x28 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM3 | 116 | K | 3.29x29 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM3 | 117 | Y | 3.30x30 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM3 | 118 | L | 3.31x31 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM3 | 119 | Q | 3.32x32 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM3 | 120 | M | 3.33x33 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM3 | 121 | V | 3.34x34 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM3 | 122 | G | 3.35x35 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM3 | 123 | M | 3.36x36 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 124 | Y | 3.37x37 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 125 | A | 3.38x38 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM3 | 126 | S | 3.39x39 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 127 | S | 3.40x40 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM3 | 128 | Y | 3.41x41 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM3 | 129 | M | 3.42x42 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM3 | 130 | I | 3.43x43 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM3 | 131 | L | 3.44x44 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM3 | 132 | A | 3.45x45 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM3 | 133 | M | 3.46x46 | PAR2 | 5NDD | CysLT1 receptor | 6RZ4 |
| TM3 | 134 | T | 3.47x47 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM3 | 135 | L | 3.48x48 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM3 | 136 | D | 3.49x49 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM3 | 137 | R | 3.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 138 | H | 3.51x51 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM3 | 139 | R | 3.52x52 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM3 | 140 | A | 3.53x53 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM3 | 141 | I | 3.54x54 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM3 | 142 | C | 3.55x55 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM3 | 143 | R | 3.56x56 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| ICL2 | 144 | P | 34.50x50 | - | - | - | - |
| ICL2 | 145 | M | 34.51x51 | CCK1 receptor | 7EZM | MT2 receptor | 6ME7 |
| ICL2 | 146 | L | 34.52x52 | CCK1 receptor | 7EZM | OX1 receptor | 6TO7 |
| ICL2 | 147 | A | 34.53x53 | CCK1 receptor | 7EZM | NTS1 receptor | 6OSA |
| ICL2 | 148 | Y | 34.54x54 | CCK1 receptor | 7EZM | - | - |
| ICL2 | 149 | R | 34.55x55 | CCK1 receptor | 7EZM | MT2 receptor | 6ME6 |
| ICL2 | 150 | H | 34.56x56 | CCK1 receptor | 7EZM | DP2 receptor | 7M8W |
| ICL2 | 151 | G | 34.57x57 | - | - | - | - |
| TM4 | 152 | S | 4.38x38 | PAR2 | 5NDD | 5-HT2B receptor | 4IB4 |
| TM4 | 153 | G | 4.39x39 | PAR2 | 5NDD | A2A receptor | 4UHR |
| TM4 | 154 | A | 4.40x40 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM4 | 155 | H | 4.41x41 | PAR2 | 5NDD | CCK1 receptor | 7EZM |
| TM4 | 156 | W | 4.42x42 | PAR2 | 5NDD | - | - |
| TM4 | 157 | N | 4.43x43 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM4 | 158 | R | 4.44x44 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM4 | 159 | P | 4.45x45 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM4 | 160 | V | 4.46x46 | PAR2 | 5NDD | TP receptor | 6IIV |
| TM4 | 161 | L | 4.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 162 | V | 4.48x48 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM4 | 163 | A | 4.49x49 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM4 | 164 | W | 4.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 165 | A | 4.51x51 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM4 | 166 | F | 4.52x52 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM4 | 167 | S | 4.53x53 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM4 | 168 | L | 4.54x54 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 169 | L | 4.55x55 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 170 | L | 4.56x56 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM4 | 171 | S | 4.57x57 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM4 | 172 | L | 4.58x59 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM4 | 173 | P | 4.59x60 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM4 | 174 | Q | 4.60x61 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM4 | 175 | L | 4.61x62 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM4 | 176 | F | 4.62x63 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM4 | 177 | I | 4.63x64 | V2 receptor | 7KH0 | V2 receptor | 7DW9 |
| TM4 | 178 | F | 4.64x65 | V2 receptor | 7KH0 | V2 receptor | 7KH0 |
| ECL2 | 179 | A | - | PAR2 | 5NDD | - | - |
| ECL2 | 180 | Q | - | PAR2 | 5NDD | - | - |
| ECL2 | 181 | R | - | PAR2 | 5NDD | - | - |
| ECL2 | 182 | N | - | PAR2 | 5NDD | - | - |
| ECL2 | 183 | V | - | PAR2 | 5NDD | - | - |
| ECL2 | 184 | E | - | PAR2 | 5NDD | - | - |
| ECL2 | 185 | G | - | PAR2 | 5NDD | - | - |
| ECL2 | 186 | G | - | PAR2 | 5NDD | - | - |
| ECL2 | 187 | S | - | PAR2 | 5NDD | - | - |
| ECL2 | 188 | G | - | PAR2 | 5NDD | - | - |
| ECL2 | 189 | V | - | PAR2 | 5NDD | - | - |
| ECL2 | 190 | T | - | PAR2 | 5NDD | - | - |
| ECL2 | 191 | D | - | PAR2 | 5NDD | - | - |
| ECL2 | 192 | C | 45.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| ECL2 | 193 | W | 45.51x51 | PAR2 | 5NDD | - | - |
| ECL2 | 194 | A | 45.52x52 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| ECL2 | 195 | C | - | V2 receptor | 7KH0 | V2 receptor | 7KH0 |
| ECL2 | 196 | F | - | - | - | - | - |
| ECL2 | 197 | A | - | V2 receptor | 7KH0 | V2 receptor | 7KH0 |
| ECL2 | 198 | E | - | V2 receptor | 7KH0 | V2 receptor | 7KH0 |
| ECL2 | 199 | P | - | V2 receptor | 7KH0 | - | - |
| TM5 | 200 | W | 5.33x34 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM5 | 201 | G | 5.34x35 | PAR2 | 5NDD | TP receptor | 6IIV |
| TM5 | 202 | R | 5.35x36 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM5 | 203 | R | 5.36x37 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM5 | 204 | T | 5.37x38 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM5 | 205 | Y | 5.38x39 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 206 | V | 5.39x40 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM5 | 207 | T | 5.40x41 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM5 | 208 | W | 5.41x42 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM5 | 209 | I | 5.42x43 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM5 | 210 | A | 5.43x44 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 211 | L | 5.44x45 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM5 | 212 | M | 5.45x46 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM5 | 213 | V | 5.46x461 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 214 | F | 5.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 215 | V | 5.48x48 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM5 | 216 | A | 5.49x49 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM5 | 217 | P | 5.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 218 | T | 5.51x51 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM5 | 219 | L | 5.52x52 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| TM5 | 220 | G | 5.53x53 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM5 | 221 | I | 5.54x54 | PAR2 | 5NDD | P2Y1 receptor | 4XNW |
| TM5 | 222 | A | 5.55x55 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 223 | A | 5.56x56 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM5 | 224 | C | 5.57x57 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM5 | 225 | Q | 5.58x58 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM5 | 226 | V | 5.59x59 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 227 | L | 5.60x60 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 228 | I | 5.61x61 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM5 | 229 | F | 5.62x62 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM5 | 230 | R | 5.63x63 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM5 | 231 | E | 5.64x64 | PAR2 | 5NDD | P2Y12 receptor | 4PXZ |
| TM5 | 232 | I | 5.65x65 | PAR2 | 5NDD | GPR52 | 6LI1 |
| TM5 | 233 | H | 5.66x66 | β2-adrenoceptor | 3SN6 | V2 receptor | 7KH0 |
| TM5 | 234 | A | 5.67x67 | β2-adrenoceptor | 3SN6 | V2 receptor | 7KH0 |
| TM5 | 235 | S | 5.68x68 | β2-adrenoceptor | 3SN6 | P2Y12 receptor | 4NTJ |
| TM5 | 236 | L | 5.69x69 | β2-adrenoceptor | 3SN6 | β2-adrenoceptor | 3SN6 |
| TM5 | 237 | V | 5.70x70 | β2-adrenoceptor | 3SN6 | P2Y12 receptor | 4NTJ |
| TM5 | 238 | P | 5.71x71 | β2-adrenoceptor | 3SN6 | V2 receptor | 7KH0 |
| TM5 | 239 | G | 5.72x72 | β2-adrenoceptor | 3SN6 | - | - |
| TM5 | 240 | P | 5.73x73 | β2-adrenoceptor | 3SN6 | - | - |
| TM5 | 241 | S | 5.74x74 | β2-adrenoceptor | 3SN6 | CCK1 receptor | 7EZM |
| TM5 | 242 | E | 5.75x75 | β2-adrenoceptor | 3SN6 | β3-adrenoceptor | 7DH5 |
| TM5 | 243 | R | 5.76x76 | β2-adrenoceptor | 3SN6 | - | - |
| ICL3 | 244 | P | - | - | - | - | - |
| ICL3 | 245 | G | - | - | - | - | - |
| ICL3 | 246 | G | - | - | - | - | - |
| ICL3 | 247 | R | - | - | - | - | - |
| ICL3 | 248 | R | - | - | - | - | - |
| ICL3 | 255 | S | - | - | - | - | - |
| ICL3 | 256 | P | - | - | - | - | - |
| ICL3 | 257 | G | - | - | - | - | - |
| ICL3 | 258 | E | - | - | - | - | - |
| ICL3 | 259 | G | - | - | - | - | - |
| TM6 | 260 | A | 6.24x24 | CCK1 receptor | 7EZM | CCK1 receptor | 7EZM |
| TM6 | 261 | H | 6.25x25 | CCK1 receptor | 7EZM | Y2 receptor | 7DDZ |
| TM6 | 262 | V | 6.26x26 | CCK1 receptor | 7EZM | β1-adrenoceptor | 7BVQ |
| TM6 | 263 | S | 6.27x27 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 264 | A | 6.28x28 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM6 | 265 | A | 6.29x29 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM6 | 266 | V | 6.30x30 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM6 | 267 | A | 6.31x31 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM6 | 268 | K | 6.32x32 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 269 | T | 6.33x33 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM6 | 270 | V | 6.34x34 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM6 | 271 | R | 6.35x35 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM6 | 272 | M | 6.36x36 | PAR2 | 5NDD | LPA6 receptor | 5XSZ |
| TM6 | 273 | T | 6.37x37 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM6 | 274 | L | 6.38x38 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM6 | 275 | V | 6.39x39 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 276 | I | 6.40x40 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM6 | 277 | V | 6.41x41 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 278 | V | 6.42x42 | PAR2 | 5NDD | succinate receptor | 6RNK |
| TM6 | 279 | V | 6.43x43 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM6 | 280 | Y | 6.44x44 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM6 | 281 | V | 6.45x45 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM6 | 282 | L | 6.46x46 | V2 receptor | 7KH0 | V2 receptor | 7KH0 |
| TM6 | 283 | C | 6.47x47 | V2 receptor | 7KH0 | V2 receptor | 7KH0 |
| TM6 | 284 | W | 6.48x48 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM6 | 285 | A | 6.49x49 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM6 | 286 | P | 6.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 287 | F | 6.51x51 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM6 | 288 | F | 6.52x52 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM6 | 289 | L | 6.53x53 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM6 | 290 | V | 6.54x54 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM6 | 291 | Q | 6.55x55 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM6 | 292 | L | 6.56x56 | PAR2 | 5NDD | PAF receptor | 5ZKQ |
| TM6 | 293 | W | 6.57x57 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM6 | 294 | A | 6.58x58 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM6 | 295 | A | 6.59x59 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM6 | 296 | W | 6.60x60 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM6 | 297 | D | 6.61x61 | PAR2 | 5NDD | CCK1 receptor | 7EZM |
| ECL3 | 298 | P | - | - | - | - | - |
| ECL3 | 299 | E | - | V2 receptor | 7KH0 | - | - |
| ECL3 | 300 | A | - | V2 receptor | 7KH0 | V2 receptor | 7KH0 |
| ECL3 | 301 | P | - | V2 receptor | 7KH0 | V2 receptor | 7KH0 |
| ECL3 | 302 | L | - | V2 receptor | 7KH0 | V2 receptor | 7KH0 |
| ECL3 | 303 | E | - | - | - | - | - |
| TM7 | 304 | G | 7.32x31 | PAR2 | 5NDD | FFA1 receptor | 5TZY |
| TM7 | 305 | A | 7.33x32 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 306 | P | 7.34x33 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM7 | 307 | F | 7.35x34 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM7 | 308 | V | 7.36x35 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM7 | 309 | L | 7.37x36 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM7 | 310 | L | 7.38x37 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM7 | 311 | M | 7.39x38 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM7 | 312 | L | 7.40x39 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM7 | 313 | L | 7.41x40 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 314 | A | 7.42x41 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| TM7 | 315 | S | 7.43x42 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM7 | 316 | L | 7.44x43 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 317 | N | 7.45x45 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 318 | S | 7.46x46 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 319 | C | 7.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 320 | T | 7.48x48 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM7 | 321 | N | 7.49x49 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| TM7 | 322 | P | 7.50x50 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 323 | W | 7.51x51 | PAR2 | 5NDD | TP receptor | 6IIV |
| TM7 | 324 | I | 7.52x52 | PAR2 | 5NDD | PAR1 | 3VW7 |
| TM7 | 325 | Y | 7.53x53 | PAR2 | 5NDD | PAR2 | 5NDD |
| TM7 | 326 | A | 7.54x54 | PAR2 | 5NDD | MC4 receptor | 6W25 |
| TM7 | 327 | S | 7.55x55 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| TM7 | 328 | F | 7.56x56 | PAR2 | 5NDD | 5-HT2B receptor | 5TVN |
| H8 | 329 | S | 8.47x47 | PAR2 | 5NDD | PAR2 | 5NDD |
| H8 | 330 | S | 8.48x48 | PAR2 | 5NDD | GPR52 | 6LI1 |
| H8 | 331 | S | 8.49x49 | PAR2 | 5NDD | P2Y12 receptor | 4NTJ |
| H8 | 332 | V | 8.50x50 | PAR2 | 5NDD | TP receptor | 6IIV |
| H8 | 333 | S | 8.51x51 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| H8 | 334 | S | 8.52x52 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| H8 | 335 | E | 8.53x53 | PAR2 | 5NDD | V2 receptor | 7KH0 |
| H8 | 336 | L | 8.54x54 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| H8 | 337 | R | 8.55x55 | PAR2 | 5NDD | GPR52 | 6LI1 |
| H8 | 338 | S | 8.56x56 | PAR2 | 5NDD | CysLT2 receptor | 6RZ6 |
| H8 | 339 | L | 8.57x57 | PAR2 | 5NDD | GPR52 | 6LI1 |
| H8 | 340 | L | 8.58x58 | PAR2 | 5NDD | PAR2 | 5NDD |
| H8 | 341 | C | 8.59x59 | MT2 receptor | 6ME7 | MC4 receptor | 6W25 |
| H8 | 342 | C | 8.60x60 | MT2 receptor | 6ME7 | MC4 receptor | 6W25 |
| H8 | 343 | A | 8.61x61 | MT2 receptor | 6ME7 | - | - |
| H8 | 344 | R | 8.62x62 | MT2 receptor | 6ME7 | - | - |
| H8 | 345 | G | 8.63x63 | MT2 receptor | 6ME7 | - | - |
| C-term | 346 | R | - | - | - | - | - |
| C-term | 347 | T | - | - | - | - | - |
| C-term | 348 | P | - | - | - | - | - |
| C-term | 349 | P | - | - | - | - | - |
| C-term | 350 | S | - | - | - | - | - |