Refined structure (6CMO) of Gi1 - Rhodopsin

RECEPTOR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-19

3D VIEW

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Structure (6CMO)
Model (AlphaFold2-Multimer)

REFINED G PROTEIN RESIDUES

Residue backbones - 354 from structure (100.0%), 0 from model (0.0%)
Residue sidechains - 352 from structure (99.4%), 2 from model (0.6%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 Structure Structure
G.HN 2 G G.HN.02 Structure Structure
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 Structure Structure
G.H1 57 H G.H1.12 Structure Structure
G.h1ha 58 E G.h1ha.01 Structure Structure
G.h1ha 59 A G.h1ha.02 Structure Structure
G.h1ha 60 G G.h1ha.03 Structure Structure
G.h1ha 61 Y G.h1ha.04 Structure Structure
G.h1ha 62 S G.h1ha.05 Structure Structure
H.HA 63 E H.HA.01 Structure Structure
H.HA 64 E H.HA.02 Structure Structure
H.HA 65 E H.HA.03 Structure Structure
H.HA 66 C H.HA.04 Structure Structure
H.HA 67 K H.HA.05 Structure Structure
H.HA 68 Q H.HA.06 Structure Structure
H.HA 69 Y H.HA.07 Structure Structure
H.HA 70 K H.HA.08 Structure Structure
H.HA 71 A H.HA.09 Structure Structure
H.HA 72 V H.HA.10 Structure Structure
H.HA 73 V H.HA.11 Structure Structure
H.HA 74 Y H.HA.12 Structure Structure
H.HA 75 S H.HA.13 Structure Structure
H.HA 76 N H.HA.14 Structure Structure
H.HA 77 T H.HA.15 Structure Structure
H.HA 78 I H.HA.16 Structure Structure
H.HA 79 Q H.HA.17 Structure Structure
H.HA 80 S H.HA.18 Structure Structure
H.HA 81 I H.HA.19 Structure Structure
H.HA 82 I H.HA.20 Structure Structure
H.HA 83 A H.HA.21 Structure Structure
H.HA 84 I H.HA.22 Structure Structure
H.HA 85 I H.HA.23 Structure Structure
H.HA 86 R H.HA.24 Structure Structure
H.HA 87 A H.HA.25 Structure Structure
H.HA 88 M H.HA.26 Structure Structure
H.HA 89 G H.HA.27 Structure Structure
H.HA 90 R H.HA.28 Structure Structure
H.HA 91 L H.HA.29 Structure Structure
H.hahb 92 K H.hahb.01 Structure Structure
H.hahb 93 I H.hahb.04 Structure Structure
H.hahb 94 D H.hahb.05 Structure Structure
H.hahb 95 F H.hahb.06 Structure Structure
H.hahb 96 G H.hahb.07 Structure Structure
H.hahb 97 D H.hahb.08 Structure Structure
H.hahb 98 S H.hahb.09 Structure Structure
H.HB 99 A H.HB.01 Structure Structure
H.HB 100 R H.HB.02 Structure Structure
H.HB 101 A H.HB.03 Structure Structure
H.HB 102 D H.HB.04 Structure Structure
H.HB 103 D H.HB.05 Structure Structure
H.HB 104 A H.HB.06 Structure Structure
H.HB 105 R H.HB.07 Structure Structure
H.HB 106 Q H.HB.08 Structure Structure
H.HB 107 L H.HB.09 Structure Structure
H.HB 108 F H.HB.10 Structure Structure
H.HB 109 V H.HB.11 Structure Structure
H.HB 110 L H.HB.12 Structure Structure
H.HB 111 A H.HB.13 Structure Structure
H.HB 112 G H.HB.14 Structure Structure
H.hbhc 113 A H.hbhc.01 Structure Structure
H.hbhc 114 A H.hbhc.02 Structure Structure
H.hbhc 115 E H.hbhc.03 Structure Structure
H.hbhc 116 E H.hbhc.04 Structure Structure
H.hbhc 117 G H.hbhc.12 Structure Structure
H.hbhc 118 F H.hbhc.13 Structure Structure
H.hbhc 119 M H.hbhc.14 Structure Structure
H.hbhc 120 T H.hbhc.15 Structure Structure
H.HC 121 A H.HC.01 Structure Structure
H.HC 122 E H.HC.02 Structure Structure
H.HC 123 L H.HC.03 Structure Structure
H.HC 124 A H.HC.04 Structure Structure
H.HC 125 G H.HC.05 Structure Structure
H.HC 126 V H.HC.06 Structure Structure
H.HC 127 I H.HC.07 Structure Structure
H.HC 128 K H.HC.08 Structure Structure
H.HC 129 R H.HC.09 Structure Structure
H.HC 130 L H.HC.10 Structure Structure
H.HC 131 W H.HC.11 Structure Structure
H.HC 132 K H.HC.12 Structure Structure
H.hchd 133 D H.hchd.01 Structure Structure
H.HD 134 S H.HD.01 Structure Structure
H.HD 135 G H.HD.02 Structure Structure
H.HD 136 V H.HD.03 Structure Structure
H.HD 137 Q H.HD.04 Structure Structure
H.HD 138 A H.HD.05 Structure Structure
H.HD 139 C H.HD.06 Structure Structure
H.HD 140 F H.HD.07 Structure Structure
H.HD 141 N H.HD.08 Structure Structure
H.HD 142 R H.HD.09 Structure Structure
H.HD 143 S H.HD.10 Structure Structure
H.HD 144 R H.HD.11 Structure Structure
H.HD 145 E H.HD.12 Structure Structure
H.hdhe 146 Y H.hdhe.01 Structure Structure
H.hdhe 147 Q H.hdhe.02 Structure Structure
H.hdhe 148 L H.hdhe.03 Structure Structure
H.hdhe 149 N H.hdhe.04 Structure Structure
H.hdhe 150 D H.hdhe.05 Structure Structure
H.HE 151 S H.HE.01 Structure Structure
H.HE 152 A H.HE.02 Structure Structure
H.HE 153 A H.HE.03 Structure Structure
H.HE 154 Y H.HE.04 Structure Structure
H.HE 155 Y H.HE.05 Structure Structure
H.HE 156 L H.HE.06 Structure Structure
H.HE 157 N H.HE.07 Structure Structure
H.HE 158 D H.HE.08 Structure Structure
H.HE 159 L H.HE.09 Structure Structure
H.HE 160 D H.HE.10 Structure Structure
H.HE 161 R H.HE.11 Structure Structure
H.HE 162 I H.HE.12 Structure Structure
H.HE 163 A H.HE.13 Structure Structure
H.hehf 164 Q H.hehf.01 Structure Structure
H.hehf 165 P H.hehf.02 Structure Structure
H.hehf 166 N H.hehf.03 Structure Structure
H.hehf 167 Y H.hehf.04 Structure Structure
H.hehf 168 I H.hehf.05 Structure Structure
H.hehf 169 P H.hehf.06 Structure Structure
H.hehf 170 T H.hehf.07 Structure Structure
H.HF 171 Q H.HF.01 Structure Structure
H.HF 172 Q H.HF.02 Structure Structure
H.HF 173 D H.HF.03 Structure Structure
H.HF 174 V H.HF.04 Structure Structure
H.HF 175 L H.HF.05 Structure Structure
H.HF 176 R H.HF.06 Structure Structure
G.hfs2 177 T G.hfs2.01 Structure Structure
G.hfs2 178 R G.hfs2.02 Structure Structure
G.hfs2 179 V G.hfs2.03 Structure Structure
G.hfs2 180 K G.hfs2.04 Structure Structure
G.hfs2 181 T G.hfs2.05 Structure Structure
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure Structure
G.s4h3 237 D G.s4h3.11 Structure Structure
G.s4h3 238 E G.s4h3.12 Structure Structure
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 321 from structure (96.7%), 11 from model (3.3%)
Residue sidechains - 318 from structure (95.8%), 14 from model (4.2%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 N - AF2 AF2
N-term 3 G - Structure Structure
N-term 4 T - Structure Structure
N-term 5 E - Structure Structure
N-term 6 G - Structure Structure
N-term 7 P - Structure Structure
N-term 8 N - Structure Structure
N-term 9 F - Structure Structure
N-term 10 Y - Structure Structure
N-term 11 V - Structure Structure
N-term 12 P - Structure Structure
N-term 13 F - Structure Structure
N-term 14 S - Structure Structure
N-term 15 N - Structure Structure
N-term 16 A - Structure Structure
N-term 17 T - Structure Structure
N-term 18 G - Structure Structure
N-term 19 V - Structure Structure
N-term 20 V - Structure Structure
N-term 21 R - Structure Structure
N-term 22 S - Structure Structure
N-term 23 P - Structure Structure
N-term 24 F - Structure Structure
N-term 25 E - Structure Structure
N-term 26 Y - Structure Structure
N-term 27 P - Structure Structure
N-term 28 Q - Structure Structure
N-term 29 Y - Structure Structure
N-term 30 Y - Structure Structure
N-term 31 L - Structure Structure
N-term 32 A - Structure Structure
TM1 33 E 1.28x28 Structure Structure
TM1 34 P 1.29x29 Structure Structure
TM1 35 W 1.30x30 Structure Structure
TM1 36 Q 1.31x31 Structure Structure
TM1 37 F 1.32x32 Structure Structure
TM1 38 S 1.33x33 Structure Structure
TM1 39 M 1.34x34 Structure Structure
TM1 40 L 1.35x35 Structure Structure
TM1 41 A 1.36x36 Structure Structure
TM1 42 A 1.37x37 Structure Structure
TM1 43 Y 1.38x38 Structure Structure
TM1 44 M 1.39x39 Structure Structure
TM1 45 F 1.40x40 Structure Structure
TM1 46 L 1.41x41 Structure Structure
TM1 47 L 1.42x42 Structure Structure
TM1 48 I 1.43x43 Structure Structure
TM1 49 V 1.44x44 Structure Structure
TM1 50 L 1.45x45 Structure Structure
TM1 51 G 1.46x46 Structure Structure
TM1 52 F 1.47x47 Structure Structure
TM1 53 P 1.48x48 Structure Structure
TM1 54 I 1.49x49 Structure Structure
TM1 55 N 1.50x50 Structure Structure
TM1 56 F 1.51x51 Structure Structure
TM1 57 L 1.52x52 Structure Structure
TM1 58 T 1.53x53 Structure Structure
TM1 59 L 1.54x54 Structure Structure
TM1 60 Y 1.55x55 Structure Structure
TM1 61 V 1.56x56 Structure Structure
TM1 62 T 1.57x57 Structure Structure
TM1 63 V 1.58x58 Structure Structure
TM1 64 Q 1.59x59 Structure Structure
TM1 65 H 1.60x60 Structure Structure
ICL1 66 K 12.48x48 Structure Structure
ICL1 67 K 12.49x49 Structure Structure
ICL1 68 L 12.50x50 Structure Structure
ICL1 69 R 12.51x51 Structure Structure
TM2 70 T 2.37x37 Structure Structure
TM2 71 P 2.38x38 Structure Structure
TM2 72 L 2.39x39 Structure Structure
TM2 73 N 2.40x40 Structure Structure
TM2 74 Y 2.41x41 Structure Structure
TM2 75 I 2.42x42 Structure Structure
TM2 76 L 2.43x43 Structure Structure
TM2 77 L 2.44x44 Structure Structure
TM2 78 N 2.45x45 Structure Structure
TM2 79 L 2.46x46 Structure Structure
TM2 80 A 2.47x47 Structure Structure
TM2 81 V 2.48x48 Structure Structure
TM2 82 A 2.49x49 Structure Structure
TM2 83 D 2.50x50 Structure Structure
TM2 84 L 2.51x51 Structure Structure
TM2 85 F 2.52x52 Structure Structure
TM2 86 M 2.53x53 Structure Structure
TM2 87 V 2.54x54 Structure Structure
TM2 88 L 2.55x55 Structure Structure
TM2 89 G 2.56x551 Structure Structure
TM2 90 G 2.57x56 Structure Structure
TM2 91 F 2.58x57 Structure Structure
TM2 92 T 2.59x58 Structure Structure
TM2 93 S 2.60x59 Structure Structure
TM2 94 T 2.61x60 Structure Structure
TM2 95 L 2.62x61 Structure Structure
TM2 96 Y 2.63x62 Structure Structure
TM2 97 T 2.64x63 Structure Structure
TM2 98 S 2.65x64 Structure Structure
TM2 99 L 2.66x65 Structure Structure
TM2 100 H 2.67x66 Structure Structure
TM2 101 G 2.68x67 Structure Structure
ECL1 102 Y 23.49x49 Structure Structure
ECL1 103 F 23.50x50 Structure Structure
ECL1 104 V 23.51x51 Structure Structure
ECL1 105 F 23.52x52 Structure Structure
TM3 106 G 3.21x21 Structure Structure
TM3 107 P 3.22x22 Structure Structure
TM3 108 T 3.23x23 Structure Structure
TM3 109 G 3.24x24 Structure Structure
TM3 110 C 3.25x25 Structure Structure
TM3 111 N 3.26x26 Structure Structure
TM3 112 L 3.27x27 Structure Structure
TM3 113 E 3.28x28 Structure AF2
TM3 114 G 3.29x29 Structure Structure
TM3 115 F 3.30x30 Structure Structure
TM3 116 F 3.31x31 Structure Structure
TM3 117 A 3.32x32 Structure Structure
TM3 118 T 3.33x33 Structure Structure
TM3 119 L 3.34x34 Structure Structure
TM3 120 G 3.35x35 Structure Structure
TM3 121 G 3.36x36 Structure Structure
TM3 122 E 3.37x37 Structure Structure
TM3 123 I 3.38x38 Structure Structure
TM3 124 A 3.39x39 Structure Structure
TM3 125 L 3.40x40 Structure Structure
TM3 126 W 3.41x41 Structure Structure
TM3 127 S 3.42x42 Structure Structure
TM3 128 L 3.43x43 Structure Structure
TM3 129 V 3.44x44 Structure Structure
TM3 130 V 3.45x45 Structure Structure
TM3 131 L 3.46x46 Structure Structure
TM3 132 A 3.47x47 Structure Structure
TM3 133 I 3.48x48 Structure Structure
TM3 134 E 3.49x49 Structure Structure
TM3 135 R 3.50x50 Structure Structure
TM3 136 Y 3.51x51 Structure Structure
TM3 137 V 3.52x52 Structure Structure
TM3 138 V 3.53x53 Structure Structure
TM3 139 V 3.54x54 Structure Structure
TM3 140 C 3.55x55 Structure Structure
TM3 141 K 3.56x56 Structure Structure
ICL2 142 P 34.50x50 Structure Structure
ICL2 143 M 34.51x51 Structure Structure
ICL2 144 S 34.52x52 Structure Structure
ICL2 145 N 34.53x53 Structure Structure
ICL2 146 F 34.54x54 Structure Structure
ICL2 147 R 34.55x55 Structure Structure
ICL2 148 F 34.56x56 Structure Structure
TM4 149 G 4.38x38 Structure Structure
TM4 150 E 4.39x39 Structure Structure
TM4 151 N 4.40x40 Structure Structure
TM4 152 H 4.41x41 Structure Structure
TM4 153 A 4.42x42 Structure Structure
TM4 154 I 4.43x43 Structure Structure
TM4 155 M 4.44x44 Structure Structure
TM4 156 G 4.45x45 Structure Structure
TM4 157 V 4.46x46 Structure Structure
TM4 158 A 4.47x47 Structure Structure
TM4 159 F 4.48x48 Structure Structure
TM4 160 T 4.49x49 Structure Structure
TM4 161 W 4.50x50 Structure Structure
TM4 162 V 4.51x51 Structure Structure
TM4 163 M 4.52x52 Structure Structure
TM4 164 A 4.53x53 Structure Structure
TM4 165 L 4.54x54 Structure Structure
TM4 166 A 4.55x55 Structure Structure
TM4 167 C 4.56x56 Structure Structure
TM4 168 A 4.57x57 Structure Structure
TM4 169 A 4.58x58 Structure Structure
TM4 170 P 4.59x59 Structure Structure
TM4 171 P 4.60x60 Structure Structure
TM4 172 L 4.61x61 Structure Structure
TM4 173 A 4.62x62 Structure Structure
TM4 174 G 4.63x63 Structure Structure
ECL2 175 W - Structure Structure
ECL2 176 S - Structure Structure
ECL2 177 R - Structure Structure
ECL2 178 Y - Structure Structure
ECL2 179 I - Structure Structure
ECL2 180 P - Structure Structure
ECL2 181 E - Structure Structure
ECL2 182 G - Structure Structure
ECL2 183 L - Structure Structure
ECL2 184 Q - Structure Structure
ECL2 185 C - Structure Structure
ECL2 186 S - Structure Structure
ECL2 187 C 45.50x50 Structure Structure
ECL2 188 G 45.51x51 Structure Structure
ECL2 189 I 45.52x52 Structure Structure
ECL2 190 D - Structure Structure
ECL2 191 Y - Structure Structure
ECL2 192 Y - Structure Structure
ECL2 193 T - Structure Structure
ECL2 194 L - Structure Structure
ECL2 195 K - Structure Structure
ECL2 196 P - Structure Structure
ECL2 197 E - Structure Structure
ECL2 198 V - Structure Structure
TM5 199 N 5.34x35 Structure Structure
TM5 200 N 5.35x36 Structure Structure
TM5 201 E 5.36x37 Structure Structure
TM5 202 S 5.37x38 Structure Structure
TM5 203 F 5.38x39 Structure Structure
TM5 204 V 5.39x40 Structure Structure
TM5 205 I 5.40x41 Structure Structure
TM5 206 Y 5.41x42 Structure Structure
TM5 207 M 5.42x43 Structure Structure
TM5 208 F 5.43x44 Structure Structure
TM5 209 V 5.44x45 Structure Structure
TM5 210 V 5.45x46 Structure Structure
TM5 211 H 5.46x461 Structure Structure
TM5 212 F 5.47x47 Structure Structure
TM5 213 T 5.48x48 Structure Structure
TM5 214 I 5.49x49 Structure Structure
TM5 215 P 5.50x50 Structure Structure
TM5 216 M 5.51x51 Structure Structure
TM5 217 I 5.52x52 Structure Structure
TM5 218 I 5.53x53 Structure Structure
TM5 219 I 5.54x54 Structure Structure
TM5 220 F 5.55x55 Structure Structure
TM5 221 F 5.56x56 Structure Structure
TM5 222 C 5.57x57 Structure Structure
TM5 223 Y 5.58x58 Structure Structure
TM5 224 G 5.59x59 Structure Structure
TM5 225 Q 5.60x60 Structure Structure
TM5 226 L 5.61x61 Structure Structure
TM5 227 V 5.62x62 Structure Structure
TM5 228 F 5.63x63 Structure Structure
TM5 229 T 5.64x64 Structure Structure
TM5 230 V 5.65x65 Structure Structure
TM5 231 K 5.66x66 Structure Structure
TM5 232 E 5.67x67 Structure Structure
TM5 233 A 5.68x68 Structure Structure
TM5 234 A 5.69x69 Structure Structure
TM5 235 A 5.70x70 Structure Structure
TM5 236 Q 5.71x71 Structure Structure
TM5 237 Q 5.72x72 Structure Structure
ICL3 238 Q - Structure Structure
ICL3 239 E - Structure Structure
ICL3 240 S - Structure Structure
TM6 241 A 6.24x24 Structure Structure
TM6 242 T 6.25x25 Structure Structure
TM6 243 T 6.26x26 Structure Structure
TM6 244 Q 6.27x27 Structure Structure
TM6 245 K 6.28x28 Structure Structure
TM6 246 A 6.29x29 Structure Structure
TM6 247 E 6.30x30 Structure Structure
TM6 248 K 6.31x31 Structure Structure
TM6 249 E 6.32x32 Structure Structure
TM6 250 V 6.33x33 Structure Structure
TM6 251 T 6.34x34 Structure Structure
TM6 252 R 6.35x35 Structure Structure
TM6 253 M 6.36x36 Structure Structure
TM6 254 V 6.37x37 Structure Structure
TM6 255 I 6.38x38 Structure Structure
TM6 256 I 6.39x39 Structure Structure
TM6 257 M 6.40x40 Structure AF2
TM6 258 V 6.41x41 Structure Structure
TM6 259 I 6.42x42 Structure Structure
TM6 260 A 6.43x43 Structure Structure
TM6 261 F 6.44x44 Structure Structure
TM6 262 L 6.45x45 Structure Structure
TM6 263 I 6.46x46 Structure Structure
TM6 264 C 6.47x47 Structure Structure
TM6 265 W 6.48x48 Structure Structure
TM6 266 V 6.49x49 Structure Structure
TM6 267 P 6.50x50 Structure Structure
TM6 268 Y 6.51x51 Structure Structure
TM6 269 A 6.52x52 Structure Structure
TM6 270 S 6.53x53 Structure Structure
TM6 271 V 6.54x54 Structure Structure
TM6 272 A 6.55x55 Structure Structure
TM6 273 F 6.56x56 Structure Structure
TM6 274 Y 6.57x57 Structure Structure
TM6 275 I 6.58x58 Structure Structure
TM6 276 F 6.59x59 Structure Structure
TM6 277 T 6.60x60 Structure Structure
TM6 278 H 6.61x61 Structure Structure
ECL3 279 Q - Structure Structure
ECL3 280 G - Structure Structure
ECL3 281 S - Structure Structure
ECL3 282 N - Structure AF2
ECL3 283 F - Structure Structure
TM7 284 G 7.31x30 Structure Structure
TM7 285 P 7.32x31 Structure Structure
TM7 286 I 7.33x32 Structure Structure
TM7 287 F 7.34x33 Structure Structure
TM7 288 M 7.35x34 Structure Structure
TM7 289 T 7.36x35 Structure Structure
TM7 290 I 7.37x36 Structure Structure
TM7 291 P 7.38x37 Structure Structure
TM7 292 A 7.39x38 Structure Structure
TM7 293 F 7.40x39 Structure Structure
TM7 294 F 7.41x40 Structure Structure
TM7 295 A 7.42x41 Structure Structure
TM7 296 K 7.43x42 Structure Structure
TM7 297 S 7.44x43 Structure Structure
TM7 298 A 7.45x45 Structure Structure
TM7 299 A 7.46x46 Structure Structure
TM7 300 I 7.47x47 Structure Structure
TM7 301 Y 7.48x48 Structure Structure
TM7 302 N 7.49x49 Structure Structure
TM7 303 P 7.50x50 Structure Structure
TM7 304 V 7.51x51 Structure Structure
TM7 305 I 7.52x52 Structure Structure
TM7 306 Y 7.53x53 Structure Structure
TM7 307 I 7.54x54 Structure Structure
TM7 308 M 7.55x55 Structure Structure
TM7 309 M 7.56x56 Structure Structure
H8 310 N 8.47x47 Structure Structure
H8 311 K 8.48x48 Structure Structure
H8 312 Q 8.49x49 Structure Structure
H8 313 F 8.50x50 Structure Structure
H8 314 R 8.51x51 Structure Structure
H8 315 N 8.52x52 Structure Structure
H8 316 C 8.53x53 Structure Structure
H8 317 M 8.54x54 Structure Structure
H8 318 L 8.55x55 Structure Structure
H8 319 T 8.56x56 Structure Structure
H8 320 T 8.57x57 Structure Structure
H8 321 I 8.58x58 Structure Structure
H8 322 C 8.59x59 Structure Structure
C-term 323 C - Structure Structure
C-term 324 G - AF2 AF2
C-term 325 K - AF2 AF2
C-term 326 N - AF2 AF2
C-term 327 P - AF2 AF2
C-term 328 L - AF2 AF2
C-term 329 G - AF2 AF2
C-term 330 D - AF2 AF2
C-term 331 D - AF2 AF2
C-term 332 E - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

NGL is a WebGL based 3D viewer powered by MMTF.

GPCR Amino Acid GPCRdb# Segment G protein Amino Acid CGN# Interaction Type
V139 3.54x54 TM3 L348 G.H5.20 hydrophobic
V138 3.53x53 TM3 C351 G.H5.23 hydrophobic
S240 - ICL3 E318 G.h4s6.12 polar
S240 - ICL3 E318 G.h4s6.12 hydrophobic
S240 - ICL3 E318 G.h4s6.12 van-der-waals
M253 6.36x36 TM6 L353 G.H5.25 hydrophobic
M253 6.36x36 TM6 L353 G.H5.25 van-der-waals
K311 8.48x48 H8 G352 G.H5.24 polar
V139 3.54x54 TM3 C351 G.H5.23 hydrophobic
A246 6.29x29 TM6 L348 G.H5.20 hydrophobic
R147 34.55x55 ICL2 A31 G.hns1.02 polar
N310 8.47x47 H8 G352 G.H5.24 hydrophobic
K245 6.28x28 TM6 F354 G.H5.26 hydrophobic
S240 - ICL3 K345 G.H5.17 polar
V250 6.33x33 TM6 L353 G.H5.25 hydrophobic
M309 7.56x56 TM7 G352 G.H5.24 van-der-waals
T242 6.25x25 TM6 F354 G.H5.26 hydrophobic
T242 6.25x25 TM6 F354 G.H5.26 van-der-waals
K141 3.56x56 TM3 D193 G.s2s3.02 ionic
A246 6.29x29 TM6 F354 G.H5.26 hydrophobic
A246 6.29x29 TM6 F354 G.H5.26 van-der-waals
R147 34.55x55 ICL2 R32 G.hns1.03 hydrophobic
Q237 5.72x72 TM5 Y320 G.S6.02 polar
A241 6.24x24 TM6 E318 G.h4s6.12 polar
E249 6.32x32 TM6 L353 G.H5.25 hydrophobic
E249 6.32x32 TM6 L353 G.H5.25 van-der-waals
K311 8.48x48 H8 F354 G.H5.26 polar
K311 8.48x48 H8 F354 G.H5.26 hydrophobic
K311 8.48x48 H8 F354 G.H5.26 van-der-waals
E239 - ICL3 Y320 G.S6.02 hydrophobic
E239 - ICL3 Y320 G.S6.02 van-der-waals
R135 3.50x50 TM3 L353 G.H5.25 hydrophobic
E249 6.32x32 TM6 F354 G.H5.26 hydrophobic
Q237 5.72x72 TM5 D341 G.H5.13 hydrophobic
T242 6.25x25 TM6 D315 G.h4s6.09 polar
V139 3.54x54 TM3 N347 G.H5.19 hydrophobic