Refined structure (6G79) of Go - 5-HT1B receptor

RECEPTOR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-19

3D VIEW

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Structure (6G79)
Model (AlphaFold2-Multimer)

REFINED G PROTEIN RESIDUES

Residue backbones - 209 from structure (59.0%), 145 from model (41.0%)
Residue sidechains - 151 from structure (42.7%), 203 from model (57.3%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 Structure AF2
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure AF2
G.HN 9 E G.HN.33 Structure Structure
G.HN 10 R G.HN.34 Structure AF2
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 L G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure AF2
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure AF2
G.HN 18 A G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 E G.HN.44 Structure AF2
G.HN 21 K G.HN.45 Structure AF2
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 K G.HN.48 Structure AF2
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 I G.HN.52 Structure Structure
G.HN 29 S G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 K G.hns1.03 Structure Structure
G.S1 33 D G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure AF2
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure AF2
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure AF2
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure AF2
G.H1 53 M G.H1.08 Structure AF2
G.H1 54 K G.H1.09 Structure AF2
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 D G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 F G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 G H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 D H.HA.03 AF2 AF2
H.HA 66 V H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 P H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 L H.HA.19 AF2 AF2
H.HA 82 A H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 V H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 D H.HA.27 AF2 AF2
H.HA 90 T H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 G H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 E H.hahb.05 AF2 AF2
H.hahb 95 Y H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 K H.hahb.09 AF2 AF2
H.HB 99 E H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 K H.HB.03 AF2 AF2
H.HB 102 A H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 K H.HB.07 AF2 AF2
H.HB 106 M H.HB.08 AF2 AF2
H.HB 107 V H.HB.09 AF2 AF2
H.HB 108 C H.HB.10 AF2 AF2
H.HB 109 D H.HB.11 AF2 AF2
H.HB 110 V H.HB.12 AF2 AF2
H.HB 111 V H.HB.13 AF2 AF2
H.HB 112 S H.HB.14 AF2 AF2
H.hbhc 113 R H.hbhc.01 AF2 AF2
H.hbhc 114 M H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 D H.hbhc.04 AF2 AF2
H.hbhc 117 T H.hbhc.05 AF2 AF2
H.hbhc 118 E H.hbhc.12 AF2 AF2
H.hbhc 119 P H.hbhc.13 AF2 AF2
H.hbhc 120 F H.hbhc.14 AF2 AF2
H.hbhc 121 S H.hbhc.15 AF2 AF2
H.HC 122 A H.HC.01 AF2 AF2
H.HC 123 E H.HC.02 AF2 AF2
H.HC 124 L H.HC.03 AF2 AF2
H.HC 125 L H.HC.04 AF2 AF2
H.HC 126 S H.HC.05 AF2 AF2
H.HC 127 A H.HC.06 AF2 AF2
H.HC 128 M H.HC.07 AF2 AF2
H.HC 129 M H.HC.08 AF2 AF2
H.HC 130 R H.HC.09 AF2 AF2
H.HC 131 L H.HC.10 AF2 AF2
H.HC 132 W H.HC.11 AF2 AF2
H.HC 133 G H.HC.12 AF2 AF2
H.hchd 134 D H.hchd.01 AF2 AF2
H.HD 135 S H.HD.01 AF2 AF2
H.HD 136 G H.HD.02 AF2 AF2
H.HD 137 I H.HD.03 AF2 AF2
H.HD 138 Q H.HD.04 AF2 AF2
H.HD 139 E H.HD.05 AF2 AF2
H.HD 140 C H.HD.06 AF2 AF2
H.HD 141 F H.HD.07 AF2 AF2
H.HD 142 N H.HD.08 AF2 AF2
H.HD 143 R H.HD.09 AF2 AF2
H.HD 144 S H.HD.10 AF2 AF2
H.HD 145 R H.HD.11 AF2 AF2
H.HD 146 E H.HD.12 AF2 AF2
H.hdhe 147 Y H.hdhe.01 AF2 AF2
H.hdhe 148 Q H.hdhe.02 AF2 AF2
H.hdhe 149 L H.hdhe.03 AF2 AF2
H.hdhe 150 N H.hdhe.04 AF2 AF2
H.hdhe 151 D H.hdhe.05 AF2 AF2
H.HE 152 S H.HE.01 AF2 AF2
H.HE 153 A H.HE.02 AF2 AF2
H.HE 154 K H.HE.03 AF2 AF2
H.HE 155 Y H.HE.04 AF2 AF2
H.HE 156 Y H.HE.05 AF2 AF2
H.HE 157 L H.HE.06 AF2 AF2
H.HE 158 D H.HE.07 AF2 AF2
H.HE 159 S H.HE.08 AF2 AF2
H.HE 160 L H.HE.09 AF2 AF2
H.HE 161 D H.HE.10 AF2 AF2
H.HE 162 R H.HE.11 AF2 AF2
H.HE 163 I H.HE.12 AF2 AF2
H.HE 164 G H.HE.13 AF2 AF2
H.hehf 165 A H.hehf.01 AF2 AF2
H.hehf 166 A H.hehf.02 AF2 AF2
H.hehf 167 D H.hehf.03 AF2 AF2
H.hehf 168 Y H.hehf.04 AF2 AF2
H.hehf 169 Q H.hehf.05 AF2 AF2
H.hehf 170 P H.hehf.06 AF2 AF2
H.hehf 171 T H.hehf.07 AF2 AF2
H.HF 172 E H.HF.01 AF2 AF2
H.HF 173 Q H.HF.02 AF2 AF2
H.HF 174 D H.HF.03 AF2 AF2
H.HF 175 I H.HF.04 AF2 AF2
H.HF 176 L H.HF.05 AF2 AF2
H.HF 177 R H.HF.06 AF2 AF2
G.hfs2 178 T G.hfs2.01 AF2 AF2
G.hfs2 179 R G.hfs2.02 AF2 AF2
G.hfs2 180 V G.hfs2.03 AF2 AF2
G.hfs2 181 K G.hfs2.04 AF2 AF2
G.hfs2 182 T G.hfs2.05 AF2 AF2
G.hfs2 183 T G.hfs2.06 Structure Structure
G.hfs2 184 G G.hfs2.07 Structure Structure
G.S2 185 I G.S2.01 Structure Structure
G.S2 186 V G.S2.02 Structure Structure
G.S2 187 E G.S2.03 Structure AF2
G.S2 188 T G.S2.04 Structure Structure
G.S2 189 H G.S2.05 Structure Structure
G.S2 190 F G.S2.06 Structure Structure
G.S2 191 T G.S2.07 Structure Structure
G.S2 192 F G.S2.08 Structure AF2
G.s2s3 193 K G.s2s3.01 Structure AF2
G.s2s3 194 N G.s2s3.02 Structure AF2
G.S3 195 L G.S3.01 Structure Structure
G.S3 196 H G.S3.02 Structure Structure
G.S3 197 F G.S3.03 Structure Structure
G.S3 198 R G.S3.04 Structure Structure
G.S3 199 L G.S3.05 Structure Structure
G.S3 200 F G.S3.06 Structure Structure
G.S3 201 D G.S3.07 Structure AF2
G.S3 202 V G.S3.08 Structure Structure
G.s3h2 203 G G.s3h2.01 Structure Structure
G.s3h2 204 G G.s3h2.02 Structure Structure
G.s3h2 205 Q G.s3h2.03 Structure Structure
G.H2 206 R G.H2.01 Structure AF2
G.H2 207 S G.H2.02 Structure Structure
G.H2 208 E G.H2.03 Structure AF2
G.H2 209 R G.H2.04 Structure AF2
G.H2 210 K G.H2.05 Structure AF2
G.H2 211 K G.H2.06 Structure Structure
G.H2 212 W G.H2.07 Structure Structure
G.H2 213 I G.H2.08 Structure Structure
G.H2 214 H G.H2.09 Structure Structure
G.H2 215 C G.H2.10 Structure Structure
G.h2s4 216 F G.h2s4.01 Structure Structure
G.h2s4 217 E G.h2s4.02 Structure AF2
G.h2s4 218 D G.h2s4.03 Structure AF2
G.h2s4 219 V G.h2s4.04 Structure Structure
G.h2s4 220 T G.h2s4.05 Structure Structure
G.S4 221 A G.S4.01 Structure Structure
G.S4 222 I G.S4.02 Structure Structure
G.S4 223 I G.S4.03 Structure Structure
G.S4 224 F G.S4.04 Structure Structure
G.S4 225 C G.S4.05 Structure Structure
G.S4 226 V G.S4.06 Structure Structure
G.S4 227 A G.S4.07 Structure AF2
G.s4h3 228 L G.s4h3.01 Structure Structure
G.s4h3 229 S G.s4h3.02 Structure Structure
G.s4h3 230 G G.s4h3.03 Structure AF2
G.s4h3 231 Y G.s4h3.04 Structure Structure
G.s4h3 232 D G.s4h3.05 AF2 AF2
G.s4h3 233 Q G.s4h3.06 AF2 AF2
G.s4h3 234 V G.s4h3.07 AF2 AF2
G.s4h3 235 L G.s4h3.08 AF2 AF2
G.s4h3 236 H G.s4h3.09 AF2 AF2
G.s4h3 237 E G.s4h3.10 AF2 AF2
G.s4h3 238 D G.s4h3.11 AF2 AF2
G.s4h3 239 E G.s4h3.12 AF2 AF2
G.s4h3 240 T G.s4h3.13 AF2 AF2
G.s4h3 241 T G.s4h3.14 AF2 AF2
G.s4h3 242 N G.s4h3.15 Structure Structure
G.H3 243 R G.H3.01 Structure AF2
G.H3 244 M G.H3.02 Structure Structure
G.H3 245 H G.H3.03 Structure Structure
G.H3 246 E G.H3.04 Structure AF2
G.H3 247 S G.H3.05 Structure Structure
G.H3 248 L G.H3.06 Structure Structure
G.H3 249 M G.H3.07 Structure AF2
G.H3 250 L G.H3.08 Structure Structure
G.H3 251 F G.H3.09 Structure Structure
G.H3 252 D G.H3.10 Structure AF2
G.H3 253 S G.H3.11 Structure Structure
G.H3 254 I G.H3.12 Structure Structure
G.H3 255 C G.H3.13 Structure Structure
G.H3 256 N G.H3.14 Structure AF2
G.H3 257 N G.H3.15 Structure Structure
G.H3 258 K G.H3.16 Structure AF2
G.H3 259 F G.H3.17 Structure Structure
G.H3 260 F G.H3.18 Structure Structure
G.h3s5 261 I G.h3s5.01 Structure Structure
G.h3s5 262 D G.h3s5.02 Structure Structure
G.h3s5 263 T G.h3s5.03 Structure Structure
G.S5 264 S G.S5.01 Structure Structure
G.S5 265 I G.S5.02 Structure Structure
G.S5 266 I G.S5.03 Structure Structure
G.S5 267 L G.S5.04 Structure Structure
G.S5 268 F G.S5.05 Structure Structure
G.S5 269 L G.S5.06 Structure Structure
G.S5 270 N G.S5.07 Structure Structure
G.s5hg 271 K G.s5hg.01 Structure Structure
G.HG 272 K G.HG.01 Structure AF2
G.HG 273 D G.HG.02 Structure AF2
G.HG 274 L G.HG.03 Structure AF2
G.HG 275 F G.HG.04 Structure Structure
G.HG 276 G G.HG.05 Structure Structure
G.HG 277 E G.HG.06 Structure AF2
G.HG 278 K G.HG.07 Structure AF2
G.HG 279 I G.HG.08 Structure Structure
G.HG 280 K G.HG.09 Structure AF2
G.HG 281 K G.HG.12 Structure AF2
G.HG 282 S G.HG.13 Structure Structure
G.HG 283 P G.HG.14 Structure Structure
G.HG 284 L G.HG.15 Structure AF2
G.HG 285 T G.HG.16 Structure AF2
G.HG 286 I G.HG.17 Structure Structure
G.hgh4 287 C G.hgh4.01 Structure Structure
G.hgh4 288 F G.hgh4.02 Structure Structure
G.hgh4 289 P G.hgh4.03 Structure Structure
G.hgh4 290 E G.hgh4.04 AF2 AF2
G.hgh4 291 Y G.hgh4.05 AF2 AF2
G.hgh4 292 T G.hgh4.06 AF2 AF2
G.hgh4 293 G G.hgh4.07 Structure Structure
G.hgh4 294 P G.hgh4.08 Structure Structure
G.H4 295 N G.H4.01 Structure AF2
G.H4 296 T G.H4.02 Structure AF2
G.H4 297 Y G.H4.03 Structure Structure
G.H4 298 E G.H4.04 Structure AF2
G.H4 299 D G.H4.05 Structure Structure
G.H4 300 A G.H4.06 Structure Structure
G.H4 301 A G.H4.07 Structure Structure
G.H4 302 A G.H4.08 Structure Structure
G.H4 303 Y G.H4.10 Structure Structure
G.H4 304 I G.H4.11 Structure Structure
G.H4 305 Q G.H4.12 Structure Structure
G.H4 306 A G.H4.13 Structure Structure
G.H4 307 Q G.H4.14 Structure Structure
G.H4 308 F G.H4.15 Structure Structure
G.H4 309 E G.H4.16 Structure AF2
G.H4 310 S G.H4.17 Structure Structure
G.h4s6 311 K G.h4s6.01 Structure Structure
G.h4s6 312 N G.h4s6.02 Structure Structure
G.h4s6 313 R G.h4s6.03 Structure Structure
G.h4s6 314 S G.h4s6.08 Structure AF2
G.h4s6 315 P G.h4s6.09 Structure Structure
G.h4s6 316 N G.h4s6.10 Structure AF2
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure AF2
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 C G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 M G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure AF2
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure AF2
G.s6h5 328 D G.s6h5.05 Structure AF2
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 N G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 I G.H5.04 Structure AF2
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 V G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure AF2
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure AF2
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 I G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 A G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 R G.H5.21 Structure AF2
G.H5 350 G G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 Y G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 262 from structure (75.7%), 84 from model (24.3%)
Residue sidechains - 226 from structure (65.3%), 120 from model (34.7%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 E - AF2 AF2
N-term 3 E - AF2 AF2
N-term 4 P - AF2 AF2
N-term 5 G - AF2 AF2
N-term 6 A - AF2 AF2
N-term 7 Q - AF2 AF2
N-term 8 C - AF2 AF2
N-term 9 A - AF2 AF2
N-term 10 P - AF2 AF2
N-term 11 P - AF2 AF2
N-term 12 P - AF2 AF2
N-term 13 P - AF2 AF2
N-term 14 A - AF2 AF2
N-term 15 G - AF2 AF2
N-term 16 S - AF2 AF2
N-term 17 E - AF2 AF2
N-term 18 T - AF2 AF2
N-term 19 W - AF2 AF2
N-term 20 V - AF2 AF2
N-term 21 P - AF2 AF2
N-term 22 Q - AF2 AF2
N-term 23 A - AF2 AF2
N-term 24 N - AF2 AF2
N-term 25 L - AF2 AF2
N-term 26 S - AF2 AF2
N-term 27 S - AF2 AF2
N-term 28 A - AF2 AF2
N-term 29 P - AF2 AF2
N-term 30 S - AF2 AF2
N-term 31 Q - AF2 AF2
N-term 32 N - AF2 AF2
N-term 33 C - AF2 AF2
N-term 34 S - AF2 AF2
N-term 35 A - AF2 AF2
N-term 36 K - AF2 AF2
N-term 37 D - AF2 AF2
N-term 38 Y - AF2 AF2
N-term 39 I - AF2 AF2
N-term 40 Y - AF2 AF2
N-term 41 Q - AF2 AF2
N-term 42 D - AF2 AF2
N-term 43 S - AF2 AF2
N-term 44 I - AF2 AF2
TM1 45 S 1.28x28 Structure Structure
TM1 46 L 1.29x29 Structure Structure
TM1 47 P 1.30x30 Structure Structure
TM1 48 W 1.31x31 Structure Structure
TM1 49 K 1.32x32 Structure AF2
TM1 50 V 1.33x33 Structure Structure
TM1 51 L 1.34x34 Structure Structure
TM1 52 L 1.35x35 Structure Structure
TM1 53 V 1.36x36 Structure Structure
TM1 54 M 1.37x37 Structure AF2
TM1 55 L 1.38x38 Structure Structure
TM1 56 L 1.39x39 Structure Structure
TM1 57 A 1.40x40 Structure Structure
TM1 58 L 1.41x41 Structure Structure
TM1 59 I 1.42x42 Structure Structure
TM1 60 T 1.43x43 Structure AF2
TM1 61 L 1.44x44 Structure Structure
TM1 62 A 1.45x45 Structure Structure
TM1 63 T 1.46x46 Structure Structure
TM1 64 T 1.47x47 Structure Structure
TM1 65 L 1.48x48 Structure AF2
TM1 66 S 1.49x49 Structure Structure
TM1 67 N 1.50x50 Structure Structure
TM1 68 A 1.51x51 Structure Structure
TM1 69 F 1.52x52 Structure Structure
TM1 70 V 1.53x53 Structure Structure
TM1 71 I 1.54x54 Structure Structure
TM1 72 A 1.55x55 Structure Structure
TM1 73 T 1.56x56 Structure Structure
TM1 74 V 1.57x57 Structure Structure
TM1 75 Y 1.58x58 Structure Structure
TM1 76 R 1.59x59 Structure AF2
TM1 77 T 1.60x60 Structure Structure
ICL1 78 R 12.48x48 Structure AF2
ICL1 79 K 12.49x49 Structure AF2
ICL1 80 L 12.50x50 Structure Structure
ICL1 81 H 12.51x51 Structure Structure
TM2 82 T 2.37x37 Structure Structure
TM2 83 P 2.38x38 Structure Structure
TM2 84 A 2.39x39 Structure Structure
TM2 85 N 2.40x40 Structure Structure
TM2 86 Y 2.41x41 Structure Structure
TM2 87 L 2.42x42 Structure Structure
TM2 88 I 2.43x43 Structure Structure
TM2 89 A 2.44x44 Structure Structure
TM2 90 S 2.45x45 Structure Structure
TM2 91 L 2.46x46 Structure Structure
TM2 92 A 2.47x47 Structure Structure
TM2 93 V 2.48x48 Structure Structure
TM2 94 T 2.49x49 Structure Structure
TM2 95 D 2.50x50 Structure Structure
TM2 96 L 2.51x51 Structure Structure
TM2 97 L 2.52x52 Structure Structure
TM2 98 V 2.53x53 Structure Structure
TM2 99 S 2.54x54 Structure Structure
TM2 100 I 2.55x55 Structure Structure
TM2 101 L 2.56x551 Structure Structure
TM2 102 V 2.57x56 Structure Structure
TM2 103 M 2.58x57 Structure AF2
TM2 104 P 2.59x58 Structure Structure
TM2 105 I 2.60x59 Structure AF2
TM2 106 S 2.61x60 Structure Structure
TM2 107 T 2.62x61 Structure Structure
TM2 108 M 2.63x62 Structure AF2
TM2 109 Y 2.64x63 Structure Structure
TM2 110 T 2.65x64 Structure Structure
TM2 111 V 2.66x65 Structure Structure
TM2 112 T 2.67x66 Structure Structure
TM2 113 G 2.68x67 Structure Structure
ECL1 114 R 23.49x49 Structure AF2
ECL1 115 W 23.50x50 Structure Structure
ECL1 116 T 23.51x51 Structure AF2
ECL1 117 L 23.52x52 Structure AF2
TM3 118 G 3.21x21 Structure Structure
TM3 119 Q 3.22x22 Structure AF2
TM3 120 V 3.23x23 Structure AF2
TM3 121 V 3.24x24 Structure Structure
TM3 122 C 3.25x25 Structure Structure
TM3 123 D 3.26x26 Structure AF2
TM3 124 F 3.27x27 Structure Structure
TM3 125 W 3.28x28 Structure Structure
TM3 126 L 3.29x29 Structure Structure
TM3 127 S 3.30x30 Structure Structure
TM3 128 S 3.31x31 Structure Structure
TM3 129 D 3.32x32 Structure Structure
TM3 130 I 3.33x33 Structure Structure
TM3 131 T 3.34x34 Structure Structure
TM3 132 C 3.35x35 Structure Structure
TM3 133 C 3.36x36 Structure Structure
TM3 134 T 3.37x37 Structure Structure
TM3 135 A 3.38x38 Structure Structure
TM3 136 S 3.39x39 Structure Structure
TM3 137 I 3.40x40 Structure Structure
TM3 138 L 3.41x41 Structure AF2
TM3 139 H 3.42x42 Structure Structure
TM3 140 L 3.43x43 Structure Structure
TM3 141 C 3.44x44 Structure Structure
TM3 142 V 3.45x45 Structure Structure
TM3 143 I 3.46x46 Structure Structure
TM3 144 A 3.47x47 Structure Structure
TM3 145 L 3.48x48 Structure Structure
TM3 146 D 3.49x49 Structure Structure
TM3 147 R 3.50x50 Structure Structure
TM3 148 Y 3.51x51 Structure Structure
TM3 149 W 3.52x52 Structure Structure
TM3 150 A 3.53x53 Structure Structure
TM3 151 I 3.54x54 Structure Structure
TM3 152 T 3.55x55 Structure Structure
TM3 153 D 3.56x56 Structure AF2
ICL2 154 A 34.50x50 Structure Structure
ICL2 155 V 34.51x51 Structure Structure
ICL2 156 E 34.52x52 Structure Structure
ICL2 157 Y 34.53x53 Structure Structure
ICL2 158 S 34.54x54 Structure Structure
ICL2 159 A 34.55x55 Structure Structure
ICL2 160 K 34.56x56 Structure Structure
ICL2 161 R 34.57x57 Structure Structure
TM4 162 T 4.38x38 Structure Structure
TM4 163 P 4.39x39 Structure Structure
TM4 164 K 4.40x40 Structure Structure
TM4 165 R 4.41x41 Structure Structure
TM4 166 A 4.42x42 Structure Structure
TM4 167 A 4.43x43 Structure Structure
TM4 168 V 4.44x44 Structure Structure
TM4 169 M 4.45x45 Structure Structure
TM4 170 I 4.46x46 Structure Structure
TM4 171 A 4.47x47 Structure Structure
TM4 172 L 4.48x48 Structure Structure
TM4 173 V 4.49x49 Structure Structure
TM4 174 W 4.50x50 Structure Structure
TM4 175 V 4.51x51 Structure Structure
TM4 176 F 4.52x52 Structure Structure
TM4 177 S 4.53x53 Structure Structure
TM4 178 I 4.54x54 Structure Structure
TM4 179 S 4.55x55 Structure Structure
TM4 180 I 4.56x56 Structure Structure
TM4 181 S 4.57x57 Structure Structure
TM4 182 L 4.58x58 Structure Structure
TM4 183 P 4.59x59 Structure Structure
TM4 184 P 4.60x60 Structure Structure
TM4 185 F 4.61x61 Structure Structure
TM4 186 F 4.62x62 Structure Structure
TM4 187 W 4.63x63 Structure Structure
ECL2 188 R - AF2 AF2
ECL2 189 Q - AF2 AF2
ECL2 190 A - AF2 AF2
ECL2 191 K - AF2 AF2
ECL2 192 A - AF2 AF2
ECL2 193 E - AF2 AF2
ECL2 194 E - AF2 AF2
ECL2 195 E - AF2 AF2
ECL2 196 V - AF2 AF2
ECL2 197 S - Structure Structure
ECL2 198 E - Structure AF2
ECL2 199 C 45.50x50 Structure Structure
ECL2 200 V 45.51x51 Structure AF2
ECL2 201 V 45.52x52 Structure Structure
ECL2 202 N - Structure Structure
ECL2 203 T - Structure Structure
ECL2 204 D - Structure Structure
TM5 205 H 5.35x36 Structure Structure
TM5 206 I 5.36x37 Structure AF2
TM5 207 L 5.37x38 Structure AF2
TM5 208 Y 5.38x39 Structure AF2
TM5 209 T 5.39x40 Structure Structure
TM5 210 V 5.40x41 Structure Structure
TM5 211 Y 5.41x42 Structure AF2
TM5 212 S 5.42x43 Structure Structure
TM5 213 T 5.43x44 Structure Structure
TM5 214 V 5.44x45 Structure Structure
TM5 215 G 5.45x46 Structure Structure
TM5 216 A 5.46x461 Structure Structure
TM5 217 F 5.47x47 Structure Structure
TM5 218 Y 5.48x48 Structure Structure
TM5 219 F 5.49x49 Structure Structure
TM5 220 P 5.50x50 Structure Structure
TM5 221 T 5.51x51 Structure Structure
TM5 222 L 5.52x52 Structure AF2
TM5 223 L 5.53x53 Structure Structure
TM5 224 L 5.54x54 Structure Structure
TM5 225 I 5.55x55 Structure Structure
TM5 226 A 5.56x56 Structure Structure
TM5 227 L 5.57x57 Structure Structure
TM5 228 Y 5.58x58 Structure Structure
TM5 229 G 5.59x59 Structure Structure
TM5 230 R 5.60x60 Structure AF2
TM5 231 I 5.61x61 Structure Structure
TM5 232 Y 5.62x62 Structure Structure
TM5 233 V 5.63x63 Structure Structure
TM5 234 E 5.64x64 Structure Structure
TM5 235 A 5.65x65 Structure Structure
TM5 236 R 5.66x66 Structure Structure
TM5 237 S 5.67x67 Structure Structure
TM5 238 R 5.68x68 Structure Structure
TM5 239 I 5.69x69 Structure Structure
TM5 240 L 5.70x70 Structure Structure
TM5 241 K 5.71x71 AF2 AF2
TM5 242 Q 5.72x72 AF2 AF2
TM5 243 T 5.73x73 AF2 AF2
TM5 244 P 5.74x74 AF2 AF2
ICL3 245 N - AF2 AF2
ICL3 246 R - AF2 AF2
ICL3 247 T - AF2 AF2
ICL3 248 G - AF2 AF2
ICL3 249 K - AF2 AF2
ICL3 250 R - AF2 AF2
ICL3 251 L - AF2 AF2
ICL3 296 D - AF2 AF2
ICL3 297 A - AF2 AF2
ICL3 298 L - AF2 AF2
ICL3 299 L - AF2 AF2
ICL3 300 E - AF2 AF2
ICL3 301 K - AF2 AF2
ICL3 302 K - AF2 AF2
TM6 303 K 6.24x24 AF2 AF2
TM6 304 L 6.25x25 AF2 AF2
TM6 305 M 6.26x26 Structure AF2
TM6 306 A 6.27x27 Structure Structure
TM6 307 A 6.28x28 Structure Structure
TM6 308 R 6.29x29 Structure Structure
TM6 309 E 6.30x30 Structure Structure
TM6 310 R 6.31x31 Structure AF2
TM6 311 K 6.32x32 Structure Structure
TM6 312 A 6.33x33 Structure Structure
TM6 313 T 6.34x34 Structure Structure
TM6 314 K 6.35x35 Structure Structure
TM6 315 T 6.36x36 Structure Structure
TM6 316 L 6.37x37 Structure Structure
TM6 317 G 6.38x38 Structure Structure
TM6 318 I 6.39x39 Structure Structure
TM6 319 I 6.40x40 Structure Structure
TM6 320 L 6.41x41 Structure Structure
TM6 321 G 6.42x42 Structure Structure
TM6 322 A 6.43x43 Structure Structure
TM6 323 F 6.44x44 Structure Structure
TM6 324 I 6.45x45 Structure Structure
TM6 325 V 6.46x46 Structure Structure
TM6 326 C 6.47x47 Structure Structure
TM6 327 W 6.48x48 Structure Structure
TM6 328 L 6.49x49 Structure Structure
TM6 329 P 6.50x50 Structure Structure
TM6 330 F 6.51x51 Structure Structure
TM6 331 F 6.52x52 Structure Structure
TM6 332 I 6.53x53 Structure Structure
TM6 333 I 6.54x54 Structure Structure
TM6 334 S 6.55x55 Structure Structure
TM6 335 L 6.56x56 Structure Structure
TM6 336 V 6.57x57 Structure Structure
TM6 337 M 6.58x58 Structure Structure
TM6 338 P 6.59x59 Structure Structure
TM6 339 I 6.60x60 AF2 AF2
TM6 340 C 6.61x61 AF2 AF2
ECL3 341 K - AF2 AF2
ECL3 342 D - AF2 AF2
ECL3 343 A - AF2 AF2
ECL3 344 C - AF2 AF2
ECL3 345 W - Structure Structure
ECL3 346 F - Structure Structure
TM7 347 H 7.31x30 Structure Structure
TM7 348 L 7.32x31 Structure AF2
TM7 349 A 7.33x32 Structure Structure
TM7 350 I 7.34x33 Structure Structure
TM7 351 F 7.35x34 Structure Structure
TM7 352 D 7.36x35 Structure AF2
TM7 353 F 7.37x36 Structure Structure
TM7 354 F 7.38x37 Structure Structure
TM7 355 T 7.39x38 Structure Structure
TM7 356 W 7.40x39 Structure Structure
TM7 357 L 7.41x40 Structure Structure
TM7 358 G 7.42x41 Structure Structure
TM7 359 Y 7.43x42 Structure Structure
TM7 360 L 7.44x43 Structure AF2
TM7 361 N 7.45x45 Structure Structure
TM7 362 S 7.46x46 Structure Structure
TM7 363 L 7.47x47 Structure Structure
TM7 364 I 7.48x48 Structure Structure
TM7 365 N 7.49x49 Structure Structure
TM7 366 P 7.50x50 Structure Structure
TM7 367 I 7.51x51 Structure Structure
TM7 368 I 7.52x52 Structure Structure
TM7 369 Y 7.53x53 Structure Structure
TM7 370 T 7.54x54 Structure Structure
TM7 371 M 7.55x55 Structure AF2
TM7 372 S 7.56x56 Structure Structure
H8 373 N 8.47x47 Structure Structure
H8 374 E 8.48x48 Structure AF2
H8 375 D 8.49x49 Structure AF2
H8 376 F 8.50x50 Structure Structure
H8 377 K 8.51x51 Structure Structure
H8 378 Q 8.52x52 Structure AF2
H8 379 A 8.53x53 Structure Structure
H8 380 F 8.54x54 Structure Structure
H8 381 H 8.55x55 Structure Structure
H8 382 K 8.56x56 Structure AF2
H8 383 L 8.57x57 Structure Structure
H8 384 I 8.58x58 Structure Structure
C-term 385 R - Structure Structure
C-term 386 F - AF2 AF2
C-term 387 K - AF2 AF2
C-term 388 C - AF2 AF2
C-term 389 T - AF2 AF2
C-term 390 S - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

NGL is a WebGL based 3D viewer powered by MMTF.

GPCR Amino Acid GPCRdb# Segment G protein Amino Acid CGN# Interaction Type
T247 - ICL3 E298 G.H4.04 hydrophobic
T247 - ICL3 E298 G.H4.04 van-der-waals
I151 3.54x54 TM3 N347 G.H5.19 hydrophobic
R238 5.68x68 TM5 D341 G.H5.13 ionic
R238 5.68x68 TM5 D341 G.H5.13 polar
R238 5.68x68 TM5 D341 G.H5.13 hydrophobic
R238 5.68x68 TM5 D341 G.H5.13 van-der-waals
R147 3.50x50 TM3 C351 G.H5.23 polar
R147 3.50x50 TM3 C351 G.H5.23 hydrophobic
R147 3.50x50 TM3 C351 G.H5.23 van-der-waals
I151 3.54x54 TM3 L348 G.H5.20 hydrophobic
I151 3.54x54 TM3 L348 G.H5.20 van-der-waals
T315 6.36x36 TM6 G352 G.H5.24 polar
T315 6.36x36 TM6 G352 G.H5.24 hydrophobic
T315 6.36x36 TM6 G352 G.H5.24 van-der-waals
I239 5.69x69 TM5 Y354 G.H5.26 hydrophobic
I239 5.69x69 TM5 Y354 G.H5.26 van-der-waals
G248 - ICL3 A302 G.H4.08 polar
G248 - ICL3 A302 G.H4.08 hydrophobic
G248 - ICL3 A302 G.H4.08 van-der-waals
A154 34.50x50 ICL2 I343 G.H5.15 hydrophobic
G248 - ICL3 Y303 G.H4.10 polar
G248 - ICL3 Y303 G.H4.10 hydrophobic
G248 - ICL3 Y303 G.H4.10 van-der-waals
K311 6.32x32 TM6 Y354 G.H5.26 polar
K311 6.32x32 TM6 Y354 G.H5.26 hydrophobic
K311 6.32x32 TM6 Y354 G.H5.26 van-der-waals
K249 - ICL3 A302 G.H4.08 polar
R238 5.68x68 TM5 I344 G.H5.16 hydrophobic
R238 5.68x68 TM5 I344 G.H5.16 van-der-waals
P244 5.74x74 TM5 E309 G.H4.16 hydrophobic
P244 5.74x74 TM5 E309 G.H4.16 van-der-waals
S372 7.56x56 TM7 C351 G.H5.23 polar
S372 7.56x56 TM7 C351 G.H5.23 hydrophobic
S372 7.56x56 TM7 C351 G.H5.23 van-der-waals
L316 6.37x37 TM6 L353 G.H5.25 hydrophobic
R308 6.29x29 TM6 Y354 G.H5.26 polar
R308 6.29x29 TM6 Y354 G.H5.26 aromatic
R308 6.29x29 TM6 Y354 G.H5.26 hydrophobic
R308 6.29x29 TM6 Y354 G.H5.26 van-der-waals
I151 3.54x54 TM3 I344 G.H5.16 hydrophobic
A312 6.33x33 TM6 L353 G.H5.25 hydrophobic
A312 6.33x33 TM6 L353 G.H5.25 van-der-waals
Q242 5.72x72 TM5 Y354 G.H5.26 polar
Q242 5.72x72 TM5 Y354 G.H5.26 hydrophobic
Q242 5.72x72 TM5 Y354 G.H5.26 van-der-waals
T315 6.36x36 TM6 L353 G.H5.25 hydrophobic
R250 - ICL3 Y303 G.H4.10 polar
Q242 5.72x72 TM5 E318 G.h4s6.12 polar
Q242 5.72x72 TM5 E318 G.h4s6.12 hydrophobic
Q242 5.72x72 TM5 E318 G.h4s6.12 van-der-waals
T247 - ICL3 Q305 G.H4.12 polar
R238 5.68x68 TM5 L348 G.H5.20 hydrophobic
A150 3.53x53 TM3 N347 G.H5.19 polar
A150 3.53x53 TM3 N347 G.H5.19 hydrophobic
A150 3.53x53 TM3 N347 G.H5.19 van-der-waals
R308 6.29x29 TM6 E318 G.h4s6.12 ionic
R308 6.29x29 TM6 E318 G.h4s6.12 polar
S372 7.56x56 TM7 G352 G.H5.24 hydrophobic
A235 5.65x65 TM5 L353 G.H5.25 hydrophobic
A154 34.50x50 ICL2 I344 G.H5.16 hydrophobic
A154 34.50x50 ICL2 I344 G.H5.16 van-der-waals
G248 - ICL3 A306 G.H4.13 hydrophobic
G248 - ICL3 A306 G.H4.13 van-der-waals
K249 - ICL3 E309 G.H4.16 ionic
K249 - ICL3 E309 G.H4.16 polar
K249 - ICL3 E309 G.H4.16 hydrophobic
K249 - ICL3 E309 G.H4.16 van-der-waals
K249 - ICL3 A306 G.H4.13 hydrophobic
K249 - ICL3 A306 G.H4.13 van-der-waals
R238 5.68x68 TM5 Y354 G.H5.26 hydrophobic
I231 5.61x61 TM5 L353 G.H5.25 hydrophobic
I231 5.61x61 TM5 L353 G.H5.25 van-der-waals
R250 - ICL3 E290 G.hgh4.04 ionic
R250 - ICL3 E290 G.hgh4.04 polar
R250 - ICL3 E290 G.hgh4.04 van-der-waals
A235 5.65x65 TM5 L348 G.H5.20 hydrophobic
T247 - ICL3 A302 G.H4.08 hydrophobic
T247 - ICL3 A302 G.H4.08 van-der-waals
V155 34.51x51 ICL2 T340 G.H5.12 hydrophobic
V155 34.51x51 ICL2 F336 G.H5.08 hydrophobic