Refined structure (6NIY) of Gs - CT receptor

RECEPTOR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-19

3D VIEW

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Structure (6NIY)
Model (AlphaFold2-Multimer)

REFINED G PROTEIN RESIDUES

Residue backbones - 168 from structure (42.6%), 226 from model (57.4%)
Residue sidechains - 167 from structure (42.4%), 227 from model (57.6%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 Structure Structure
G.HN 11 D G.HN.28 Structure Structure
G.HN 12 Q G.HN.29 Structure Structure
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 AF2 AF2
G.s1h1 49 G G.s1h1.03 AF2 AF2
G.s1h1 50 E G.s1h1.04 AF2 AF2
G.s1h1 51 S G.s1h1.05 AF2 AF2
G.s1h1 52 G G.s1h1.06 AF2 AF2
G.H1 53 K G.H1.01 AF2 AF2
G.H1 54 S G.H1.02 AF2 AF2
G.H1 55 T G.H1.03 AF2 AF2
G.H1 56 I G.H1.04 AF2 AF2
G.H1 57 V G.H1.05 AF2 AF2
G.H1 58 K G.H1.06 AF2 AF2
G.H1 59 Q G.H1.07 AF2 AF2
G.H1 60 M G.H1.08 AF2 AF2
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 AF2 AF2
G.hfs2 206 G G.hfs2.07 AF2 AF2
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure AF2
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure Structure
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 AF2 AF2
G.s4h3 252 S G.s4h3.03 AF2 AF2
G.s4h3 253 Y G.s4h3.04 AF2 AF2
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 AF2 AF2
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure Structure
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure Structure
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure Structure
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure Structure
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure Structure
G.h3s5 285 I G.h3s5.03 Structure Structure
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 AF2 AF2
G.HG 294 Q G.HG.01 AF2 AF2
G.HG 295 D G.HG.02 AF2 AF2
G.HG 296 L G.HG.03 AF2 AF2
G.HG 297 L G.HG.04 AF2 AF2
G.HG 298 A G.HG.05 AF2 AF2
G.HG 299 E G.HG.06 AF2 AF2
G.HG 300 K G.HG.07 AF2 AF2
G.HG 301 V G.HG.08 AF2 AF2
G.HG 302 L G.HG.09 AF2 AF2
G.HG 303 A G.HG.10 AF2 AF2
G.HG 304 G G.HG.11 AF2 AF2
G.HG 305 K G.HG.12 AF2 AF2
G.HG 306 S G.HG.13 AF2 AF2
G.HG 307 K G.HG.14 AF2 AF2
G.HG 308 I G.HG.15 AF2 AF2
G.HG 309 E G.HG.16 AF2 AF2
G.HG 310 D G.HG.17 AF2 AF2
G.hgh4 311 Y G.hgh4.01 AF2 AF2
G.hgh4 312 F G.hgh4.02 AF2 AF2
G.hgh4 313 P G.hgh4.03 AF2 AF2
G.hgh4 314 E G.hgh4.04 AF2 AF2
G.hgh4 315 F G.hgh4.05 AF2 AF2
G.hgh4 316 A G.hgh4.06 AF2 AF2
G.hgh4 317 R G.hgh4.07 AF2 AF2
G.hgh4 318 Y G.hgh4.08 AF2 AF2
G.hgh4 319 T G.hgh4.09 AF2 AF2
G.hgh4 320 T G.hgh4.10 AF2 AF2
G.hgh4 321 P G.hgh4.11 AF2 AF2
G.hgh4 322 E G.hgh4.12 AF2 AF2
G.hgh4 323 D G.hgh4.13 AF2 AF2
G.hgh4 324 A G.hgh4.14 AF2 AF2
G.hgh4 325 T G.hgh4.15 AF2 AF2
G.hgh4 326 P G.hgh4.16 AF2 AF2
G.hgh4 327 E G.hgh4.17 AF2 AF2
G.hgh4 328 P G.hgh4.18 AF2 AF2
G.hgh4 329 G G.hgh4.19 AF2 AF2
G.hgh4 330 E G.hgh4.20 AF2 AF2
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 AF2 AF2
G.h4s6 354 D G.h4s6.10 AF2 AF2
G.h4s6 355 G G.h4s6.11 AF2 AF2
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 AF2 AF2
G.s6h5 367 V G.s6h5.04 AF2 AF2
G.s6h5 368 D G.s6h5.05 AF2 AF2
G.H5 369 T G.H5.01 AF2 AF2
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 261 from structure (60.7%), 169 from model (39.3%)
Residue sidechains - 261 from structure (60.7%), 169 from model (39.3%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 R - AF2 AF2
N-term 3 F - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 F - AF2 AF2
N-term 6 T - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 R - AF2 AF2
N-term 9 C - AF2 AF2
N-term 10 L - AF2 AF2
N-term 11 A - AF2 AF2
N-term 12 L - AF2 AF2
N-term 13 F - AF2 AF2
N-term 14 L - AF2 AF2
N-term 15 L - AF2 AF2
N-term 16 L - AF2 AF2
N-term 17 N - AF2 AF2
N-term 18 H - AF2 AF2
N-term 19 P - AF2 AF2
N-term 20 T - AF2 AF2
N-term 21 P - AF2 AF2
N-term 22 I - AF2 AF2
N-term 23 L - AF2 AF2
N-term 24 P - AF2 AF2
N-term 25 A - AF2 AF2
N-term 26 F - AF2 AF2
N-term 27 S - AF2 AF2
N-term 28 N - AF2 AF2
N-term 29 Q - AF2 AF2
N-term 30 T - AF2 AF2
N-term 31 Y - AF2 AF2
N-term 32 P - AF2 AF2
N-term 33 T - AF2 AF2
N-term 34 I - AF2 AF2
N-term 35 E - AF2 AF2
N-term 36 P - AF2 AF2
N-term 37 K - AF2 AF2
N-term 38 P - AF2 AF2
N-term 39 F - AF2 AF2
N-term 40 L - AF2 AF2
N-term 41 Y - AF2 AF2
N-term 42 V - AF2 AF2
N-term 43 V - AF2 AF2
N-term 44 G - AF2 AF2
N-term 45 R - AF2 AF2
N-term 46 K - AF2 AF2
N-term 47 K - AF2 AF2
N-term 48 M - AF2 AF2
N-term 49 M - AF2 AF2
N-term 50 D - AF2 AF2
N-term 51 A - AF2 AF2
N-term 52 Q - AF2 AF2
N-term 53 Y - AF2 AF2
N-term 54 K - AF2 AF2
N-term 55 C - AF2 AF2
N-term 56 Y - AF2 AF2
N-term 57 D - AF2 AF2
N-term 58 R - AF2 AF2
N-term 59 M - AF2 AF2
N-term 60 Q - AF2 AF2
N-term 61 Q - AF2 AF2
N-term 62 L - AF2 AF2
N-term 63 P - AF2 AF2
N-term 64 A - AF2 AF2
N-term 65 Y - AF2 AF2
N-term 66 Q - AF2 AF2
N-term 67 G - AF2 AF2
N-term 68 E - AF2 AF2
N-term 69 G - AF2 AF2
N-term 70 P - AF2 AF2
N-term 71 Y - AF2 AF2
N-term 72 C - AF2 AF2
N-term 73 N - AF2 AF2
N-term 74 R - AF2 AF2
N-term 75 T - AF2 AF2
N-term 76 W - AF2 AF2
N-term 77 D - AF2 AF2
N-term 78 G - AF2 AF2
N-term 79 W - AF2 AF2
N-term 80 L - AF2 AF2
N-term 81 C - AF2 AF2
N-term 82 W - AF2 AF2
N-term 83 D - AF2 AF2
N-term 84 D - AF2 AF2
N-term 85 T - AF2 AF2
N-term 86 P - AF2 AF2
N-term 87 A - AF2 AF2
N-term 88 G - AF2 AF2
N-term 89 V - AF2 AF2
N-term 90 L - AF2 AF2
N-term 91 S - AF2 AF2
N-term 92 Y - AF2 AF2
N-term 93 Q - AF2 AF2
N-term 94 F - AF2 AF2
N-term 95 C - AF2 AF2
N-term 96 P - AF2 AF2
N-term 97 D - AF2 AF2
N-term 98 Y - AF2 AF2
N-term 99 F - AF2 AF2
N-term 100 P - AF2 AF2
N-term 101 D - AF2 AF2
N-term 102 F - AF2 AF2
N-term 103 D - AF2 AF2
N-term 104 P - AF2 AF2
N-term 105 S - AF2 AF2
N-term 106 E - AF2 AF2
N-term 107 K - AF2 AF2
N-term 108 V - AF2 AF2
N-term 109 T - AF2 AF2
N-term 110 K - AF2 AF2
N-term 111 Y - AF2 AF2
N-term 112 C - AF2 AF2
N-term 113 D - AF2 AF2
N-term 114 E - AF2 AF2
N-term 115 K - AF2 AF2
N-term 116 G - AF2 AF2
N-term 117 V - AF2 AF2
N-term 118 W - AF2 AF2
N-term 119 F - AF2 AF2
N-term 120 K - AF2 AF2
N-term 121 H - AF2 AF2
N-term 122 P - AF2 AF2
N-term 123 E - AF2 AF2
N-term 124 N - AF2 AF2
N-term 125 N - AF2 AF2
N-term 126 R - AF2 AF2
N-term 127 T - AF2 AF2
N-term 128 W - AF2 AF2
N-term 129 S - AF2 AF2
N-term 130 N - AF2 AF2
N-term 131 Y - AF2 AF2
TM1 132 T 1.23x23 AF2 AF2
TM1 133 M 1.24x24 AF2 AF2
TM1 134 C 1.25x25 AF2 AF2
TM1 135 N 1.26x26 AF2 AF2
TM1 136 A 1.27x27 AF2 AF2
TM1 137 F 1.28x28 AF2 AF2
TM1 138 T 1.29x29 Structure Structure
TM1 139 P 1.30x30 Structure Structure
TM1 140 E 1.31x31 Structure Structure
TM1 141 K 1.32x32 Structure Structure
TM1 142 L 1.33x33 Structure Structure
TM1 143 K 1.34x34 Structure Structure
TM1 144 N 1.35x35 Structure Structure
TM1 145 A 1.36x36 Structure Structure
TM1 146 Y 1.37x37 Structure Structure
TM1 147 V 1.38x38 Structure Structure
TM1 148 L 1.39x39 Structure Structure
TM1 149 Y 1.40x40 Structure Structure
TM1 150 Y 1.41x41 Structure Structure
TM1 151 L 1.42x42 Structure Structure
TM1 152 A 1.43x43 Structure Structure
TM1 153 I 1.44x44 Structure Structure
TM1 154 V 1.45x45 Structure Structure
TM1 155 G 1.46x46 Structure Structure
TM1 156 H 1.47x47 Structure Structure
TM1 157 S 1.48x48 Structure Structure
TM1 158 L 1.49x49 Structure Structure
TM1 159 S 1.50x50 Structure Structure
TM1 160 I 1.51x51 Structure Structure
TM1 161 F 1.52x52 Structure Structure
TM1 162 T 1.53x53 Structure Structure
TM1 163 L 1.54x54 Structure Structure
TM1 164 V 1.55x55 Structure Structure
TM1 165 I 1.56x56 Structure Structure
TM1 166 S 1.57x57 Structure Structure
TM1 167 L 1.58x58 Structure Structure
TM1 168 G 1.59x59 Structure Structure
TM1 169 I 1.60x60 Structure Structure
TM1 170 F 1.61x61 Structure Structure
TM1 171 V 1.62x62 Structure Structure
TM1 172 F 1.63x63 Structure Structure
TM1 173 F 1.64x64 Structure Structure
ICL1 174 R 12.48x48 Structure Structure
ICL1 175 S 12.49x49 Structure Structure
ICL1 176 L 12.50x50 Structure Structure
ICL1 177 G 12.51x51 Structure Structure
TM2 178 C 2.44x44 Structure Structure
TM2 179 Q 2.45x45 Structure Structure
TM2 180 R 2.46x46 Structure Structure
TM2 181 V 2.47x47 Structure Structure
TM2 182 T 2.48x48 Structure Structure
TM2 183 L 2.49x49 Structure Structure
TM2 184 H 2.50x50 Structure Structure
TM2 185 K 2.51x51 Structure Structure
TM2 186 N 2.52x52 Structure Structure
TM2 187 M 2.53x53 Structure Structure
TM2 188 F 2.54x54 Structure Structure
TM2 189 L 2.55x55 Structure Structure
TM2 190 T 2.56x56 Structure Structure
TM2 191 Y 2.57x57 Structure Structure
TM2 192 I 2.58x58 Structure Structure
TM2 193 L 2.59x59 Structure Structure
TM2 194 N 2.60x60 Structure Structure
TM2 195 S 2.61x61 Structure Structure
TM2 196 M 2.62x62 Structure Structure
TM2 197 I 2.63x63 Structure Structure
TM2 198 I 2.64x64 Structure Structure
TM2 199 I 2.65x65 Structure Structure
TM2 200 I 2.66x66 Structure Structure
TM2 201 H 2.67x67 Structure Structure
TM2 202 L 2.68x68 Structure Structure
TM2 203 V 2.69x69 Structure Structure
TM2 204 E 2.70x70 Structure Structure
TM2 205 V 2.71x71 Structure Structure
ECL1 206 V - AF2 AF2
ECL1 207 P - AF2 AF2
ECL1 208 N - AF2 AF2
ECL1 209 G - AF2 AF2
ECL1 210 E - AF2 AF2
ECL1 211 L - AF2 AF2
ECL1 212 V - AF2 AF2
ECL1 213 R - AF2 AF2
ECL1 214 R - AF2 AF2
ECL1 215 D - AF2 AF2
TM3 216 P 3.26x26 AF2 AF2
TM3 217 V 3.27x27 Structure Structure
TM3 218 S 3.28x28 Structure Structure
TM3 219 C 3.29x29 Structure Structure
TM3 220 K 3.30x30 Structure Structure
TM3 221 I 3.31x31 Structure Structure
TM3 222 L 3.32x32 Structure Structure
TM3 223 H 3.33x33 Structure Structure
TM3 224 F 3.34x34 Structure Structure
TM3 225 F 3.35x35 Structure Structure
TM3 226 H 3.36x36 Structure Structure
TM3 227 Q 3.37x37 Structure Structure
TM3 228 Y 3.38x38 Structure Structure
TM3 229 M 3.39x39 Structure Structure
TM3 230 M 3.40x40 Structure Structure
TM3 231 A 3.41x41 Structure Structure
TM3 232 C 3.42x42 Structure Structure
TM3 233 N 3.43x43 Structure Structure
TM3 234 Y 3.44x44 Structure Structure
TM3 235 F 3.45x45 Structure Structure
TM3 236 W 3.46x46 Structure Structure
TM3 237 M 3.47x47 Structure Structure
TM3 238 L 3.48x48 Structure Structure
TM3 239 C 3.49x49 Structure Structure
TM3 240 E 3.50x50 Structure Structure
TM3 241 G 3.51x51 Structure Structure
TM3 242 I 3.52x52 Structure Structure
TM3 243 Y 3.53x53 Structure Structure
TM3 244 L 3.54x54 Structure Structure
TM3 245 H 3.55x55 Structure Structure
TM3 246 T 3.56x56 Structure Structure
TM3 247 L 3.57x57 Structure Structure
TM3 248 I 3.58x58 Structure Structure
TM3 249 V 3.59x59 Structure Structure
TM3 250 V 3.60x60 Structure Structure
ICL2 251 A - Structure Structure
ICL2 252 V - Structure Structure
ICL2 253 F - Structure Structure
ICL2 254 T - Structure Structure
ICL2 255 E - Structure Structure
ICL2 256 K - Structure Structure
ICL2 257 Q - Structure Structure
TM4 258 R 4.41x42 Structure Structure
TM4 259 L 4.42x43 Structure Structure
TM4 260 R 4.43x44 Structure Structure
TM4 261 W 4.44x45 Structure Structure
TM4 262 Y 4.45x46 Structure Structure
TM4 263 Y 4.46x47 Structure Structure
TM4 264 L 4.47x48 Structure Structure
TM4 265 L 4.48x49 Structure Structure
TM4 266 G 4.49x491 Structure Structure
TM4 267 W 4.50x50 Structure Structure
TM4 268 G 4.51x51 Structure Structure
TM4 269 F 4.52x52 Structure Structure
TM4 270 P 4.53x53 Structure Structure
TM4 271 L 4.54x54 Structure Structure
TM4 272 V 4.55x55 Structure Structure
TM4 273 P 4.56x56 Structure Structure
TM4 274 T 4.57x57 Structure Structure
TM4 275 T 4.58x58 Structure Structure
TM4 276 I 4.59x59 Structure Structure
TM4 277 H 4.60x60 Structure Structure
TM4 278 A 4.61x61 Structure Structure
TM4 279 I 4.62x62 Structure Structure
TM4 280 T 4.63x63 Structure Structure
TM4 281 R 4.64x64 Structure Structure
TM4 282 A 4.65x65 Structure Structure
TM4 283 V 4.66x66 Structure Structure
TM4 284 Y 4.67x67 Structure Structure
TM4 285 F 4.68x68 Structure Structure
ECL2 286 N - Structure Structure
ECL2 287 D - Structure Structure
ECL2 288 N - Structure Structure
ECL2 289 C 45.50x50 Structure Structure
ECL2 290 W 45.51x51 Structure Structure
ECL2 291 L 45.52x52 Structure Structure
ECL2 292 S - Structure Structure
ECL2 293 V - Structure Structure
ECL2 294 E - Structure Structure
ECL2 295 T - Structure Structure
ECL2 296 H - Structure Structure
ECL2 297 L - Structure Structure
TM5 298 L 5.36x37 Structure Structure
TM5 299 Y 5.37x38 Structure Structure
TM5 300 I 5.38x381 Structure Structure
TM5 301 I 5.39x39 Structure Structure
TM5 302 H 5.40x40 Structure Structure
TM5 303 G 5.41x41 Structure Structure
TM5 304 P 5.42x42 Structure Structure
TM5 305 V 5.43x43 Structure Structure
TM5 306 M 5.44x44 Structure Structure
TM5 307 A 5.45x45 Structure Structure
TM5 308 A 5.46x46 Structure Structure
TM5 309 L 5.47x47 Structure Structure
TM5 310 V 5.48x48 Structure Structure
TM5 311 V 5.49x49 Structure Structure
TM5 312 N 5.50x50 Structure Structure
TM5 313 F 5.51x51 Structure Structure
TM5 314 F 5.52x52 Structure Structure
TM5 315 F 5.53x53 Structure Structure
TM5 316 L 5.54x54 Structure Structure
TM5 317 L 5.55x55 Structure Structure
TM5 318 N 5.56x56 Structure Structure
TM5 319 I 5.57x57 Structure Structure
TM5 320 V 5.58x58 Structure Structure
TM5 321 R 5.59x59 Structure Structure
TM5 322 V 5.60x60 Structure Structure
TM5 323 L 5.61x61 Structure Structure
TM5 324 V 5.62x62 Structure Structure
TM5 325 T 5.63x63 Structure Structure
TM5 326 K 5.64x64 Structure Structure
TM5 327 M 5.65x65 Structure Structure
TM5 328 R 5.66x66 Structure Structure
TM5 329 E 5.67x67 Structure Structure
TM5 330 T 5.68x68 Structure Structure
TM5 331 H 5.69x69 AF2 AF2
ICL3 332 E - AF2 AF2
TM6 333 A 6.30x30 AF2 AF2
TM6 334 E 6.31x31 AF2 AF2
TM6 335 S 6.32x32 AF2 AF2
TM6 336 H 6.33x33 Structure Structure
TM6 337 M 6.34x34 Structure Structure
TM6 338 Y 6.35x35 Structure Structure
TM6 339 L 6.36x36 Structure Structure
TM6 340 K 6.37x37 Structure Structure
TM6 341 A 6.38x38 Structure Structure
TM6 342 V 6.39x39 Structure Structure
TM6 343 K 6.40x40 Structure Structure
TM6 344 A 6.41x41 Structure Structure
TM6 345 T 6.42x42 Structure Structure
TM6 346 M 6.43x43 Structure Structure
TM6 347 I 6.44x44 Structure Structure
TM6 348 L 6.45x45 Structure Structure
TM6 349 V 6.46x46 Structure Structure
TM6 350 P 6.47x47 Structure Structure
TM6 351 L 6.48x48 Structure Structure
TM6 352 L 6.49x49 Structure Structure
TM6 353 G 6.50x50 Structure Structure
TM6 354 I 6.51x51 Structure Structure
TM6 355 Q 6.52x52 Structure Structure
TM6 356 F 6.53x53 Structure Structure
TM6 357 V 6.54x54 Structure Structure
TM6 358 V 6.55x55 Structure Structure
TM6 359 F 6.56x56 Structure Structure
TM6 360 P 6.57x57 Structure Structure
TM6 361 W 6.58x58 Structure Structure
ECL3 362 R - Structure Structure
ECL3 363 P - Structure Structure
ECL3 364 S - Structure Structure
TM7 365 N 7.31x30 Structure Structure
TM7 366 K 7.32x31 Structure Structure
TM7 367 M 7.33x32 Structure Structure
TM7 368 L 7.34x33 Structure Structure
TM7 369 G 7.35x34 Structure Structure
TM7 370 K 7.36x35 Structure Structure
TM7 371 I 7.37x36 Structure Structure
TM7 372 Y 7.38x37 Structure Structure
TM7 373 D 7.39x38 Structure Structure
TM7 374 Y 7.40x39 Structure Structure
TM7 375 V 7.41x40 Structure Structure
TM7 376 M 7.42x41 Structure Structure
TM7 377 H 7.43x42 Structure Structure
TM7 378 S 7.44x43 Structure Structure
TM7 379 L 7.45x44 Structure Structure
TM7 380 I 7.46x45 Structure Structure
TM7 381 H 7.47x46 Structure Structure
TM7 382 F 7.48x47 Structure Structure
TM7 383 Q 7.49x49 Structure Structure
TM7 384 G 7.50x50 Structure Structure
TM7 385 F 7.51x51 Structure Structure
TM7 386 F 7.52x52 Structure Structure
TM7 387 V 7.53x53 Structure Structure
TM7 388 A 7.54x54 Structure Structure
TM7 389 T 7.55x55 Structure Structure
TM7 390 I 7.56x56 Structure Structure
TM7 391 Y 7.57x57 Structure Structure
TM7 392 C 7.58x58 Structure Structure
TM7 393 F 7.59x59 Structure Structure
TM7 394 C 7.60x60 Structure Structure
H8 395 N 8.47x47 Structure Structure
H8 396 N 8.48x48 Structure Structure
H8 397 E 8.49x49 Structure Structure
H8 398 V 8.50x50 Structure Structure
H8 399 Q 8.51x51 Structure Structure
H8 400 T 8.52x52 Structure Structure
H8 401 T 8.53x53 Structure Structure
H8 402 V 8.54x54 Structure Structure
H8 403 K 8.55x55 Structure Structure
H8 404 R 8.56x56 Structure Structure
H8 405 Q 8.57x57 Structure Structure
H8 406 W 8.58x58 Structure Structure
H8 407 A 8.59x59 Structure Structure
H8 408 Q 8.60x60 Structure Structure
H8 409 F 8.61x61 Structure Structure
H8 410 K 8.62x62 Structure Structure
H8 411 I 8.63x63 Structure Structure
H8 412 Q 8.64x64 Structure Structure
H8 413 W 8.65x65 Structure Structure
H8 414 N 8.66x66 Structure Structure
H8 415 Q 8.67x67 AF2 AF2
H8 416 R 8.68x68 AF2 AF2
H8 417 W 8.69x69 AF2 AF2
H8 418 G 8.70x70 AF2 AF2
H8 419 R 8.71x71 AF2 AF2
H8 420 R 8.72x72 AF2 AF2
C-term 421 P - AF2 AF2
C-term 422 S - AF2 AF2
C-term 423 N - AF2 AF2
C-term 424 R - AF2 AF2
C-term 425 S - AF2 AF2
C-term 426 A - AF2 AF2
C-term 427 R - AF2 AF2
C-term 428 A - AF2 AF2
C-term 429 A - AF2 AF2
C-term 430 A - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

NGL is a WebGL based 3D viewer powered by MMTF.

GPCR Amino Acid GPCRdb# Segment G protein Amino Acid CGN# Interaction Type
F253 - ICL2 H41 G.S1.02 aromatic
F253 - ICL2 H41 G.S1.02 hydrophobic
F253 - ICL2 H41 G.S1.02 van-der-waals
K326 5.64x64 TM5 L394 G.H5.26 hydrophobic
K326 5.64x64 TM5 L394 G.H5.26 van-der-waals
K343 6.40x40 TM6 E392 G.H5.24 polar
L348 6.45x45 TM6 L393 G.H5.25 hydrophobic
M327 5.65x65 TM5 L394 G.H5.26 hydrophobic
M327 5.65x65 TM5 L394 G.H5.26 van-der-waals
R180 2.46x46 TM2 Q390 G.H5.22 polar
R180 2.46x46 TM2 Q390 G.H5.22 hydrophobic
R180 2.46x46 TM2 Q390 G.H5.22 van-der-waals
K326 5.64x64 TM5 Q384 G.H5.16 polar
K326 5.64x64 TM5 Q384 G.H5.16 hydrophobic
K326 5.64x64 TM5 Q384 G.H5.16 van-der-waals
V252 - ICL2 Q384 G.H5.16 hydrophobic
V252 - ICL2 Q384 G.H5.16 van-der-waals
K340 6.37x37 TM6 L394 G.H5.26 hydrophobic
K326 5.64x64 TM5 R385 G.H5.17 polar
K326 5.64x64 TM5 R385 G.H5.17 hydrophobic
K326 5.64x64 TM5 R385 G.H5.17 van-der-waals
L247 3.57x57 TM3 H387 G.H5.19 hydrophobic
L247 3.57x57 TM3 H387 G.H5.19 van-der-waals
K326 5.64x64 TM5 L388 G.H5.20 hydrophobic
A344 6.41x41 TM6 L393 G.H5.25 hydrophobic
F253 - ICL2 F376 G.H5.08 hydrophobic
L247 3.57x57 TM3 Y391 G.H5.23 hydrophobic
V252 - ICL2 I383 G.H5.15 hydrophobic
L323 5.61x61 TM5 L393 G.H5.25 hydrophobic
L323 5.61x61 TM5 L393 G.H5.25 van-der-waals
V249 3.59x59 TM3 R380 G.H5.12 polar
V249 3.59x59 TM3 R380 G.H5.12 van-der-waals
T330 5.68x68 TM5 Y358 G.h4s6.20 hydrophobic
T330 5.68x68 TM5 Y358 G.h4s6.20 van-der-waals
L244 3.54x54 TM3 Y391 G.H5.23 hydrophobic
L244 3.54x54 TM3 Y391 G.H5.23 van-der-waals
L323 5.61x61 TM5 L388 G.H5.20 hydrophobic
Y243 3.53x53 TM3 Y391 G.H5.23 van-der-waals
F253 - ICL2 I383 G.H5.15 hydrophobic
F253 - ICL2 I383 G.H5.15 van-der-waals
K326 5.64x64 TM5 D381 G.H5.13 ionic
K326 5.64x64 TM5 D381 G.H5.13 polar
K326 5.64x64 TM5 D381 G.H5.13 van-der-waals
N395 8.47x47 H8 E392 G.H5.24 polar
N395 8.47x47 H8 E392 G.H5.24 hydrophobic
N395 8.47x47 H8 E392 G.H5.24 van-der-waals
F253 - ICL2 V217 G.S3.01 hydrophobic
F253 - ICL2 V217 G.S3.01 van-der-waals
I248 3.58x58 TM3 L388 G.H5.20 hydrophobic
I248 3.58x58 TM3 L388 G.H5.20 van-der-waals
V252 - ICL2 H387 G.H5.19 polar
V252 - ICL2 H387 G.H5.19 van-der-waals
V252 - ICL2 R380 G.H5.12 hydrophobic
V252 - ICL2 R380 G.H5.12 van-der-waals
N395 8.47x47 H8 Q390 G.H5.22 polar
I347 6.44x44 TM6 L393 G.H5.25 hydrophobic
N396 8.48x48 H8 E392 G.H5.24 polar
N396 8.48x48 H8 E392 G.H5.24 van-der-waals
Y391 7.57x57 TM7 Y391 G.H5.23 hydrophobic
R180 2.46x46 TM2 Y391 G.H5.23 aromatic
R180 2.46x46 TM2 Y391 G.H5.23 hydrophobic
R180 2.46x46 TM2 Y391 G.H5.23 van-der-waals
H184 2.50x50 TM2 Y391 G.H5.23 hydrophobic
I248 3.58x58 TM3 Q384 G.H5.16 polar
I248 3.58x58 TM3 Q384 G.H5.16 hydrophobic
I248 3.58x58 TM3 Q384 G.H5.16 van-der-waals
I319 5.57x57 TM5 L393 G.H5.25 hydrophobic