Refined structure (7BB7) of Gs - V2 receptor

RECEPTOR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-19

3D VIEW

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Structure (7BB7)
Model (AlphaFold2-Multimer)

REFINED G PROTEIN RESIDUES

Residue backbones - 218 from structure (55.3%), 176 from model (44.7%)
Residue sidechains - 218 from structure (55.3%), 176 from model (44.7%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 Structure Structure
G.HN 12 Q G.HN.29 Structure Structure
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 AF2 AF2
G.s1h1 48 A G.s1h1.02 AF2 AF2
G.s1h1 49 G G.s1h1.03 AF2 AF2
G.s1h1 50 E G.s1h1.04 AF2 AF2
G.s1h1 51 S G.s1h1.05 AF2 AF2
G.s1h1 52 G G.s1h1.06 AF2 AF2
G.H1 53 K G.H1.01 AF2 AF2
G.H1 54 S G.H1.02 AF2 AF2
G.H1 55 T G.H1.03 AF2 AF2
G.H1 56 I G.H1.04 AF2 AF2
G.H1 57 V G.H1.05 AF2 AF2
G.H1 58 K G.H1.06 AF2 AF2
G.H1 59 Q G.H1.07 AF2 AF2
G.H1 60 M G.H1.08 AF2 AF2
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 AF2 AF2
G.hfs2 206 G G.hfs2.07 AF2 AF2
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure Structure
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure Structure
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 Structure Structure
G.s4h3 261 N G.s4h3.12 Structure Structure
G.s4h3 262 Q G.s4h3.13 Structure Structure
G.s4h3 263 T G.s4h3.14 Structure Structure
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure Structure
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure Structure
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure Structure
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure Structure
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure Structure
G.h3s5 285 I G.h3s5.03 Structure Structure
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure Structure
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 266 from structure (75.4%), 87 from model (24.6%)
Residue sidechains - 266 from structure (75.4%), 87 from model (24.6%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 L - AF2 AF2
N-term 3 M - AF2 AF2
N-term 4 A - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 T - AF2 AF2
N-term 7 T - AF2 AF2
N-term 8 S - AF2 AF2
N-term 9 A - AF2 AF2
N-term 10 V - AF2 AF2
N-term 11 P - AF2 AF2
N-term 12 G - AF2 AF2
N-term 13 H - AF2 AF2
N-term 14 P - AF2 AF2
N-term 15 S - AF2 AF2
N-term 16 L - AF2 AF2
N-term 17 P - AF2 AF2
N-term 18 S - AF2 AF2
N-term 19 L - AF2 AF2
N-term 20 P - AF2 AF2
N-term 21 S - AF2 AF2
N-term 22 N - AF2 AF2
N-term 23 S - AF2 AF2
N-term 24 S - AF2 AF2
N-term 25 Q - AF2 AF2
N-term 26 E - AF2 AF2
N-term 27 R - AF2 AF2
N-term 28 P - AF2 AF2
N-term 29 L - AF2 AF2
N-term 30 D - AF2 AF2
N-term 31 T - AF2 AF2
N-term 32 R - AF2 AF2
TM1 33 D 1.28x28 Structure Structure
TM1 34 P 1.29x29 Structure Structure
TM1 35 L 1.30x30 Structure Structure
TM1 36 L 1.31x31 Structure Structure
TM1 37 A 1.32x32 Structure Structure
TM1 38 R 1.33x33 Structure Structure
TM1 39 A 1.34x34 Structure Structure
TM1 40 E 1.35x35 Structure Structure
TM1 41 L 1.36x36 Structure Structure
TM1 42 A 1.37x37 Structure Structure
TM1 43 L 1.38x38 Structure Structure
TM1 44 L 1.39x39 Structure Structure
TM1 45 S 1.40x40 Structure Structure
TM1 46 I 1.41x41 Structure Structure
TM1 47 V 1.42x42 Structure Structure
TM1 48 F 1.43x43 Structure Structure
TM1 49 V 1.44x44 Structure Structure
TM1 50 A 1.45x45 Structure Structure
TM1 51 V 1.46x46 Structure Structure
TM1 52 A 1.47x47 Structure Structure
TM1 53 L 1.48x48 Structure Structure
TM1 54 S 1.49x49 Structure Structure
TM1 55 N 1.50x50 Structure Structure
TM1 56 G 1.51x51 Structure Structure
TM1 57 L 1.52x52 Structure Structure
TM1 58 V 1.53x53 Structure Structure
TM1 59 L 1.54x54 Structure Structure
TM1 60 A 1.55x55 Structure Structure
TM1 61 A 1.56x56 Structure Structure
TM1 62 L 1.57x57 Structure Structure
TM1 63 A 1.58x58 Structure Structure
TM1 64 R 1.59x59 Structure Structure
TM1 65 R 1.60x60 Structure Structure
TM1 66 G 1.61x61 Structure Structure
TM1 67 R 1.62x62 Structure Structure
TM1 68 R 1.63x63 Structure Structure
TM1 69 G 1.64x64 Structure Structure
ICL1 70 H - Structure Structure
ICL1 71 W - Structure Structure
TM2 72 A 2.37x37 Structure Structure
TM2 73 P 2.38x38 Structure Structure
TM2 74 I 2.39x39 Structure Structure
TM2 75 H 2.40x40 Structure Structure
TM2 76 V 2.41x41 Structure Structure
TM2 77 F 2.42x42 Structure Structure
TM2 78 I 2.43x43 Structure Structure
TM2 79 G 2.44x44 Structure Structure
TM2 80 H 2.45x45 Structure Structure
TM2 81 L 2.46x46 Structure Structure
TM2 82 C 2.47x47 Structure Structure
TM2 83 L 2.48x48 Structure Structure
TM2 84 A 2.49x49 Structure Structure
TM2 85 D 2.50x50 Structure Structure
TM2 86 L 2.51x51 Structure Structure
TM2 87 A 2.52x52 Structure Structure
TM2 88 V 2.53x53 Structure Structure
TM2 89 A 2.54x54 Structure Structure
TM2 90 L 2.55x55 Structure Structure
TM2 91 F 2.56x551 Structure Structure
TM2 92 Q 2.57x56 Structure Structure
TM2 93 V 2.58x57 Structure Structure
TM2 94 L 2.59x58 Structure Structure
TM2 95 P 2.60x59 Structure Structure
TM2 96 Q 2.61x60 Structure Structure
TM2 97 L 2.62x61 Structure Structure
TM2 98 A 2.63x62 Structure Structure
TM2 99 W 2.64x63 Structure Structure
TM2 100 K 2.65x64 Structure Structure
TM2 101 A 2.66x65 Structure Structure
TM2 102 T 2.67x66 Structure Structure
TM2 103 D 2.68x67 Structure Structure
ECL1 104 R 23.49x49 Structure Structure
ECL1 105 F 23.50x50 Structure Structure
ECL1 106 R 23.51x51 Structure Structure
ECL1 107 G 23.52x52 Structure Structure
TM3 108 P 3.21x21 Structure Structure
TM3 109 D 3.22x22 Structure Structure
TM3 110 A 3.23x23 Structure Structure
TM3 111 L 3.24x24 Structure Structure
TM3 112 C 3.25x25 Structure Structure
TM3 113 R 3.26x26 Structure Structure
TM3 114 A 3.27x27 Structure Structure
TM3 115 V 3.28x28 Structure Structure
TM3 116 K 3.29x29 Structure Structure
TM3 117 Y 3.30x30 Structure Structure
TM3 118 L 3.31x31 Structure Structure
TM3 119 Q 3.32x32 Structure Structure
TM3 120 M 3.33x33 Structure Structure
TM3 121 V 3.34x34 Structure Structure
TM3 122 G 3.35x35 Structure Structure
TM3 123 M 3.36x36 Structure Structure
TM3 124 Y 3.37x37 Structure Structure
TM3 125 A 3.38x38 Structure Structure
TM3 126 S 3.39x39 Structure Structure
TM3 127 S 3.40x40 Structure Structure
TM3 128 Y 3.41x41 Structure Structure
TM3 129 M 3.42x42 Structure Structure
TM3 130 I 3.43x43 Structure Structure
TM3 131 L 3.44x44 Structure Structure
TM3 132 A 3.45x45 Structure Structure
TM3 133 M 3.46x46 Structure Structure
TM3 134 T 3.47x47 Structure Structure
TM3 135 L 3.48x48 Structure Structure
TM3 136 D 3.49x49 Structure Structure
TM3 137 R 3.50x50 Structure Structure
TM3 138 H 3.51x51 Structure Structure
TM3 139 R 3.52x52 Structure Structure
TM3 140 A 3.53x53 Structure Structure
TM3 141 I 3.54x54 Structure Structure
TM3 142 C 3.55x55 Structure Structure
TM3 143 R 3.56x56 AF2 AF2
ICL2 144 P 34.50x50 AF2 AF2
ICL2 145 M 34.51x51 AF2 AF2
ICL2 146 L 34.52x52 AF2 AF2
ICL2 147 A 34.53x53 AF2 AF2
ICL2 148 Y 34.54x54 AF2 AF2
ICL2 149 R 34.55x55 AF2 AF2
ICL2 150 H 34.56x56 AF2 AF2
ICL2 151 G 34.57x57 AF2 AF2
TM4 152 S 4.38x38 AF2 AF2
TM4 153 G 4.39x39 AF2 AF2
TM4 154 A 4.40x40 AF2 AF2
TM4 155 H 4.41x41 AF2 AF2
TM4 156 W 4.42x42 AF2 AF2
TM4 157 N 4.43x43 AF2 AF2
TM4 158 R 4.44x44 Structure Structure
TM4 159 P 4.45x45 Structure Structure
TM4 160 V 4.46x46 Structure Structure
TM4 161 L 4.47x47 Structure Structure
TM4 162 V 4.48x48 Structure Structure
TM4 163 A 4.49x49 Structure Structure
TM4 164 W 4.50x50 Structure Structure
TM4 165 A 4.51x51 Structure Structure
TM4 166 F 4.52x52 Structure Structure
TM4 167 S 4.53x53 Structure Structure
TM4 168 L 4.54x54 Structure Structure
TM4 169 L 4.55x55 Structure Structure
TM4 170 L 4.56x56 Structure Structure
TM4 171 S 4.57x57 Structure Structure
TM4 172 L 4.58x59 Structure Structure
TM4 173 P 4.59x60 Structure Structure
TM4 174 Q 4.60x61 Structure Structure
TM4 175 L 4.61x62 Structure Structure
TM4 176 F 4.62x63 Structure Structure
TM4 177 I 4.63x64 Structure Structure
TM4 178 F 4.64x65 Structure Structure
ECL2 179 A - Structure Structure
ECL2 180 Q - Structure Structure
ECL2 181 R - Structure Structure
ECL2 182 N - Structure Structure
ECL2 183 V - Structure Structure
ECL2 184 E - Structure Structure
ECL2 185 G - Structure Structure
ECL2 186 G - Structure Structure
ECL2 187 S - Structure Structure
ECL2 188 G - Structure Structure
ECL2 189 V - Structure Structure
ECL2 190 T - Structure Structure
ECL2 191 D - Structure Structure
ECL2 192 C 45.50x50 Structure Structure
ECL2 193 W 45.51x51 Structure Structure
ECL2 194 A 45.52x52 Structure Structure
ECL2 195 C - Structure Structure
ECL2 196 F - Structure Structure
ECL2 197 A - Structure Structure
ECL2 198 E - Structure Structure
ECL2 199 P - Structure Structure
TM5 200 W 5.33x34 Structure Structure
TM5 201 G 5.34x35 Structure Structure
TM5 202 R 5.35x36 Structure Structure
TM5 203 R 5.36x37 Structure Structure
TM5 204 T 5.37x38 Structure Structure
TM5 205 Y 5.38x39 Structure Structure
TM5 206 V 5.39x40 Structure Structure
TM5 207 T 5.40x41 Structure Structure
TM5 208 W 5.41x42 Structure Structure
TM5 209 I 5.42x43 Structure Structure
TM5 210 A 5.43x44 Structure Structure
TM5 211 L 5.44x45 Structure Structure
TM5 212 M 5.45x46 Structure Structure
TM5 213 V 5.46x461 Structure Structure
TM5 214 F 5.47x47 Structure Structure
TM5 215 V 5.48x48 Structure Structure
TM5 216 A 5.49x49 Structure Structure
TM5 217 P 5.50x50 Structure Structure
TM5 218 T 5.51x51 Structure Structure
TM5 219 L 5.52x52 Structure Structure
TM5 220 G 5.53x53 Structure Structure
TM5 221 I 5.54x54 Structure Structure
TM5 222 A 5.55x55 Structure Structure
TM5 223 A 5.56x56 Structure Structure
TM5 224 C 5.57x57 Structure Structure
TM5 225 Q 5.58x58 Structure Structure
TM5 226 V 5.59x59 Structure Structure
TM5 227 L 5.60x60 Structure Structure
TM5 228 I 5.61x61 Structure Structure
TM5 229 F 5.62x62 Structure Structure
TM5 230 R 5.63x63 Structure Structure
TM5 231 E 5.64x64 Structure Structure
TM5 232 I 5.65x65 Structure Structure
TM5 233 H 5.66x66 Structure Structure
TM5 234 A 5.67x67 Structure Structure
TM5 235 S 5.68x68 Structure Structure
TM5 236 L 5.69x69 AF2 AF2
TM5 237 V 5.70x70 AF2 AF2
TM5 238 P 5.71x71 AF2 AF2
TM5 239 G 5.72x72 AF2 AF2
TM5 240 P 5.73x73 AF2 AF2
TM5 241 S 5.74x74 AF2 AF2
TM5 242 E 5.75x75 AF2 AF2
TM5 243 R 5.76x76 AF2 AF2
ICL3 244 P - AF2 AF2
ICL3 245 G - AF2 AF2
ICL3 246 G - AF2 AF2
ICL3 247 R - AF2 AF2
ICL3 248 R - AF2 AF2
ICL3 249 R - AF2 AF2
ICL3 250 G - AF2 AF2
ICL3 253 T - AF2 AF2
ICL3 254 G - AF2 AF2
ICL3 255 S - AF2 AF2
ICL3 256 P - AF2 AF2
ICL3 257 G - AF2 AF2
ICL3 258 E - AF2 AF2
ICL3 259 G - AF2 AF2
TM6 260 A 6.24x24 AF2 AF2
TM6 261 H 6.25x25 AF2 AF2
TM6 262 V 6.26x26 AF2 AF2
TM6 263 S 6.27x27 Structure Structure
TM6 264 A 6.28x28 Structure Structure
TM6 265 A 6.29x29 Structure Structure
TM6 266 V 6.30x30 Structure Structure
TM6 267 A 6.31x31 Structure Structure
TM6 268 K 6.32x32 Structure Structure
TM6 269 T 6.33x33 Structure Structure
TM6 270 V 6.34x34 Structure Structure
TM6 271 R 6.35x35 Structure Structure
TM6 272 M 6.36x36 Structure Structure
TM6 273 T 6.37x37 Structure Structure
TM6 274 L 6.38x38 Structure Structure
TM6 275 V 6.39x39 Structure Structure
TM6 276 I 6.40x40 Structure Structure
TM6 277 V 6.41x41 Structure Structure
TM6 278 V 6.42x42 Structure Structure
TM6 279 V 6.43x43 Structure Structure
TM6 280 Y 6.44x44 Structure Structure
TM6 281 V 6.45x45 Structure Structure
TM6 282 L 6.46x46 Structure Structure
TM6 283 C 6.47x47 Structure Structure
TM6 284 W 6.48x48 Structure Structure
TM6 285 A 6.49x49 Structure Structure
TM6 286 P 6.50x50 Structure Structure
TM6 287 F 6.51x51 Structure Structure
TM6 288 F 6.52x52 Structure Structure
TM6 289 L 6.53x53 Structure Structure
TM6 290 V 6.54x54 Structure Structure
TM6 291 Q 6.55x55 Structure Structure
TM6 292 L 6.56x56 Structure Structure
TM6 293 W 6.57x57 Structure Structure
TM6 294 A 6.58x58 Structure Structure
TM6 295 A 6.59x59 Structure Structure
TM6 296 W 6.60x60 Structure Structure
TM6 297 D 6.61x61 Structure Structure
ECL3 298 P - Structure Structure
ECL3 299 E - Structure Structure
ECL3 300 A - Structure Structure
ECL3 301 P - Structure Structure
ECL3 302 L - Structure Structure
ECL3 303 E - Structure Structure
TM7 304 G 7.32x31 Structure Structure
TM7 305 A 7.33x32 Structure Structure
TM7 306 P 7.34x33 Structure Structure
TM7 307 F 7.35x34 Structure Structure
TM7 308 V 7.36x35 Structure Structure
TM7 309 L 7.37x36 Structure Structure
TM7 310 L 7.38x37 Structure Structure
TM7 311 M 7.39x38 Structure Structure
TM7 312 L 7.40x39 Structure Structure
TM7 313 L 7.41x40 Structure Structure
TM7 314 A 7.42x41 Structure Structure
TM7 315 S 7.43x42 Structure Structure
TM7 316 L 7.44x43 Structure Structure
TM7 317 N 7.45x45 Structure Structure
TM7 318 S 7.46x46 Structure Structure
TM7 319 C 7.47x47 Structure Structure
TM7 320 T 7.48x48 Structure Structure
TM7 321 N 7.49x49 Structure Structure
TM7 322 P 7.50x50 Structure Structure
TM7 323 W 7.51x51 Structure Structure
TM7 324 I 7.52x52 Structure Structure
TM7 325 Y 7.53x53 Structure Structure
TM7 326 A 7.54x54 Structure Structure
TM7 327 S 7.55x55 Structure Structure
TM7 328 F 7.56x56 Structure Structure
H8 329 S 8.47x47 Structure Structure
H8 330 S 8.48x48 Structure Structure
H8 331 S 8.49x49 Structure Structure
H8 332 V 8.50x50 Structure Structure
H8 333 S 8.51x51 Structure Structure
H8 334 S 8.52x52 Structure Structure
H8 335 E 8.53x53 Structure Structure
H8 336 L 8.54x54 Structure Structure
H8 337 R 8.55x55 Structure Structure
H8 338 S 8.56x56 Structure Structure
H8 339 L 8.57x57 Structure Structure
H8 340 L 8.58x58 Structure Structure
H8 341 C 8.59x59 AF2 AF2
H8 342 C 8.60x60 AF2 AF2
H8 343 A 8.61x61 AF2 AF2
H8 344 R 8.62x62 AF2 AF2
H8 345 G 8.63x63 AF2 AF2
C-term 346 R - AF2 AF2
C-term 347 T - AF2 AF2
C-term 348 P - AF2 AF2
C-term 349 P - AF2 AF2
C-term 350 S - AF2 AF2
C-term 351 L - AF2 AF2
C-term 352 G - AF2 AF2
C-term 353 P - AF2 AF2
C-term 354 Q - AF2 AF2
C-term 355 D - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

NGL is a WebGL based 3D viewer powered by MMTF.

GPCR Amino Acid GPCRdb# Segment G protein Amino Acid CGN# Interaction Type
I141 3.54x54 TM3 Q384 G.H5.16 hydrophobic
I141 3.54x54 TM3 Q384 G.H5.16 van-der-waals
P144 34.50x50 ICL2 I383 G.H5.15 hydrophobic
P144 34.50x50 ICL2 I383 G.H5.15 van-der-waals
R149 34.55x55 ICL2 N218 G.S3.02 polar
R149 34.55x55 ICL2 N218 G.S3.02 hydrophobic
R149 34.55x55 ICL2 N218 G.S3.02 van-der-waals
G246 - ICL3 Y339 G.H4.08 polar
E242 5.75x75 TM5 D323 G.hgh4.13 polar
E242 5.75x75 TM5 D323 G.hgh4.13 hydrophobic
E242 5.75x75 TM5 D323 G.hgh4.13 van-der-waals
A147 34.53x53 ICL2 T40 G.S1.01 polar
A147 34.53x53 ICL2 T40 G.S1.01 hydrophobic
R137 3.50x50 TM3 L394 G.H5.26 polar
R137 3.50x50 TM3 L394 G.H5.26 hydrophobic
R137 3.50x50 TM3 L394 G.H5.26 van-der-waals
G250 - ICL3 E322 G.hgh4.12 polar
G250 - ICL3 E322 G.hgh4.12 hydrophobic
G250 - ICL3 E322 G.hgh4.12 van-der-waals
M145 34.51x51 ICL2 C379 G.H5.11 hydrophobic
M145 34.51x51 ICL2 C379 G.H5.11 van-der-waals
P240 5.73x73 TM5 P361 G.S6.03 hydrophobic
P240 5.73x73 TM5 P361 G.S6.03 van-der-waals
D136 3.49x49 TM3 Y391 G.H5.23 polar
S152 4.38x38 TM4 V36 G.HN.53 polar
S152 4.38x38 TM4 V36 G.HN.53 hydrophobic
S152 4.38x38 TM4 V36 G.HN.53 van-der-waals
G153 4.39x39 TM4 A39 G.hns1.03 hydrophobic
H261 6.25x25 TM6 T350 G.h4s6.03 polar
H261 6.25x25 TM6 T350 G.h4s6.03 hydrophobic
H261 6.25x25 TM6 T350 G.h4s6.03 van-der-waals
D355 - C-term T284 G.h3s5.02 van-der-waals
G151 34.57x57 ICL2 V36 G.HN.53 hydrophobic
G151 34.57x57 ICL2 V36 G.HN.53 van-der-waals
R247 - ICL3 A324 G.hgh4.14 polar
R247 - ICL3 A324 G.hgh4.14 hydrophobic
R247 - ICL3 A324 G.hgh4.14 van-der-waals
E231 5.64x64 TM5 Q384 G.H5.16 hydrophobic
E231 5.64x64 TM5 Q384 G.H5.16 van-der-waals
G254 - ICL3 D343 G.H4.13 polar
G254 - ICL3 D343 G.H4.13 hydrophobic
G254 - ICL3 D343 G.H4.13 van-der-waals
R247 - ICL3 D323 G.hgh4.13 polar
R247 - ICL3 D323 G.hgh4.13 hydrophobic
R247 - ICL3 D323 G.hgh4.13 van-der-waals
S152 4.38x38 TM4 R38 G.hns1.02 polar
S152 4.38x38 TM4 R38 G.hns1.02 hydrophobic
S152 4.38x38 TM4 R38 G.hns1.02 van-der-waals
A140 3.53x53 TM3 H387 G.H5.19 hydrophobic
A140 3.53x53 TM3 H387 G.H5.19 van-der-waals
Y148 34.54x54 ICL2 F219 G.S3.03 polar
Y148 34.54x54 ICL2 F219 G.S3.03 hydrophobic
R149 34.55x55 ICL2 F376 G.H5.08 aromatic
R149 34.55x55 ICL2 F376 G.H5.08 hydrophobic
R149 34.55x55 ICL2 F376 G.H5.08 van-der-waals
A154 4.40x40 TM4 Q35 G.HN.52 polar
A154 4.40x40 TM4 Q35 G.HN.52 hydrophobic
A154 4.40x40 TM4 Q35 G.HN.52 van-der-waals
P144 34.50x50 ICL2 F376 G.H5.08 hydrophobic
P144 34.50x50 ICL2 F376 G.H5.08 van-der-waals
G246 - ICL3 T325 G.hgh4.15 polar
G246 - ICL3 T325 G.hgh4.15 hydrophobic
G246 - ICL3 T325 G.hgh4.15 van-der-waals
Y148 34.54x54 ICL2 T40 G.S1.01 polar
Y148 34.54x54 ICL2 T40 G.S1.01 hydrophobic
Y148 34.54x54 ICL2 T40 G.S1.01 van-der-waals
S255 - ICL3 Y318 G.hgh4.08 polar
S255 - ICL3 Y318 G.hgh4.08 hydrophobic
S255 - ICL3 Y318 G.hgh4.08 van-der-waals
E242 5.75x75 TM5 R342 G.H4.12 ionic
E242 5.75x75 TM5 R342 G.H4.12 polar
E242 5.75x75 TM5 R342 G.H4.12 hydrophobic
E242 5.75x75 TM5 R342 G.H4.12 van-der-waals
G246 - ICL3 D323 G.hgh4.13 hydrophobic
G246 - ICL3 D323 G.hgh4.13 van-der-waals
I74 2.39x39 TM2 Q390 G.H5.22 hydrophobic
I74 2.39x39 TM2 Q390 G.H5.22 van-der-waals
M272 6.36x36 TM6 L393 G.H5.25 hydrophobic
M272 6.36x36 TM6 L393 G.H5.25 van-der-waals
R248 - ICL3 A324 G.hgh4.14 polar
R248 - ICL3 A324 G.hgh4.14 hydrophobic
R248 - ICL3 A324 G.hgh4.14 van-der-waals
P240 5.73x73 TM5 L346 G.H4.16 hydrophobic
P240 5.73x73 TM5 L346 G.H4.16 van-der-waals
S255 - ICL3 D343 G.H4.13 polar
S255 - ICL3 D343 G.H4.13 hydrophobic
S255 - ICL3 D343 G.H4.13 van-der-waals
A147 34.53x53 ICL2 H41 G.S1.02 hydrophobic
R149 34.55x55 ICL2 V214 G.S2.08 polar
R149 34.55x55 ICL2 V214 G.S2.08 hydrophobic
R149 34.55x55 ICL2 V214 G.S2.08 van-der-waals
T269 6.33x33 TM6 R385 G.H5.17 hydrophobic
E242 5.75x75 TM5 P321 G.hgh4.11 hydrophobic
E242 5.75x75 TM5 P321 G.hgh4.11 van-der-waals
S329 8.47x47 H8 Q390 G.H5.22 polar
S329 8.47x47 H8 Q390 G.H5.22 hydrophobic
S329 8.47x47 H8 Q390 G.H5.22 van-der-waals
G245 - ICL3 T325 G.hgh4.15 hydrophobic
G245 - ICL3 T325 G.hgh4.15 van-der-waals
S241 5.74x74 TM5 K338 G.H4.07 polar
S241 5.74x74 TM5 K338 G.H4.07 hydrophobic
S241 5.74x74 TM5 K338 G.H4.07 van-der-waals
R248 - ICL3 P321 G.hgh4.11 hydrophobic
R248 - ICL3 P321 G.hgh4.11 van-der-waals
R249 - ICL3 E322 G.hgh4.12 polar
R249 - ICL3 E322 G.hgh4.12 hydrophobic
R249 - ICL3 E322 G.hgh4.12 van-der-waals
G151 34.57x57 ICL2 N218 G.S3.02 polar
G151 34.57x57 ICL2 N218 G.S3.02 van-der-waals
T253 - ICL3 P321 G.hgh4.11 hydrophobic
T253 - ICL3 P321 G.hgh4.11 van-der-waals
G257 - ICL3 A351 G.h4s6.04 hydrophobic
G257 - ICL3 A351 G.h4s6.04 van-der-waals
R64 1.59x59 TM1 Q390 G.H5.22 polar
R64 1.59x59 TM1 Q390 G.H5.22 van-der-waals
A140 3.53x53 TM3 I383 G.H5.15 hydrophobic
G69 1.64x64 TM1 Q35 G.HN.52 polar
D136 3.49x49 TM3 H387 G.H5.19 ionic
D136 3.49x49 TM3 H387 G.H5.19 polar
M272 6.36x36 TM6 E392 G.H5.24 hydrophobic
M272 6.36x36 TM6 E392 G.H5.24 van-der-waals
M145 34.51x51 ICL2 F376 G.H5.08 hydrophobic
M145 34.51x51 ICL2 F376 G.H5.08 van-der-waals
R149 34.55x55 ICL2 D215 G.s2s3.01 ionic
R149 34.55x55 ICL2 D215 G.s2s3.01 polar
R149 34.55x55 ICL2 D215 G.s2s3.01 hydrophobic
R149 34.55x55 ICL2 D215 G.s2s3.01 van-der-waals
Y148 34.54x54 ICL2 C379 G.H5.11 polar
Y148 34.54x54 ICL2 C379 G.H5.11 van-der-waals
E258 - ICL3 R342 G.H4.12 ionic
E258 - ICL3 R342 G.H4.12 polar
E258 - ICL3 R342 G.H4.12 hydrophobic
E258 - ICL3 R342 G.H4.12 van-der-waals
H70 - ICL1 Q35 G.HN.52 polar
H70 - ICL1 Q35 G.HN.52 hydrophobic
H70 - ICL1 Q35 G.HN.52 van-der-waals
G250 - ICL3 T320 G.hgh4.10 polar
G250 - ICL3 T320 G.hgh4.10 hydrophobic
G250 - ICL3 T320 G.hgh4.10 van-der-waals
I141 3.54x54 TM3 L394 G.H5.26 hydrophobic
I141 3.54x54 TM3 L394 G.H5.26 van-der-waals
D355 - C-term R283 G.h3s5.01 ionic
D355 - C-term R283 G.h3s5.01 polar
D355 - C-term R283 G.h3s5.01 van-der-waals
E242 5.75x75 TM5 Y339 G.H4.08 polar
E242 5.75x75 TM5 Y339 G.H4.08 hydrophobic
E242 5.75x75 TM5 Y339 G.H4.08 van-der-waals
A72 2.37x37 TM2 A39 G.hns1.03 hydrophobic
A72 2.37x37 TM2 A39 G.hns1.03 van-der-waals
I141 3.54x54 TM3 H387 G.H5.19 hydrophobic
S327 7.55x55 TM7 L393 G.H5.25 hydrophobic
S327 7.55x55 TM7 L393 G.H5.25 van-der-waals
H155 4.41x41 TM4 Q35 G.HN.52 polar
H155 4.41x41 TM4 Q35 G.HN.52 hydrophobic
H155 4.41x41 TM4 Q35 G.HN.52 van-der-waals
M145 34.51x51 ICL2 V217 G.S3.01 hydrophobic
M145 34.51x51 ICL2 V217 G.S3.01 van-der-waals
R248 - ICL3 D323 G.hgh4.13 polar
R248 - ICL3 D323 G.hgh4.13 hydrophobic
R248 - ICL3 D323 G.hgh4.13 van-der-waals
P244 - ICL3 T325 G.hgh4.15 hydrophobic
P240 5.73x73 TM5 R342 G.H4.12 hydrophobic
P240 5.73x73 TM5 R342 G.H4.12 van-der-waals
A154 4.40x40 TM4 R38 G.hns1.02 hydrophobic
R249 - ICL3 D323 G.hgh4.13 hydrophobic
R249 - ICL3 D323 G.hgh4.13 van-der-waals
I74 2.39x39 TM2 H387 G.H5.19 hydrophobic
G151 34.57x57 ICL2 A39 G.hns1.03 hydrophobic
M145 34.51x51 ICL2 F219 G.S3.03 hydrophobic
M145 34.51x51 ICL2 F219 G.S3.03 van-der-waals
M133 3.46x46 TM3 Y391 G.H5.23 hydrophobic
E258 - ICL3 D343 G.H4.13 polar
E258 - ICL3 D343 G.H4.13 hydrophobic
E258 - ICL3 D343 G.H4.13 van-der-waals
A140 3.53x53 TM3 Q384 G.H5.16 polar
A140 3.53x53 TM3 Q384 G.H5.16 hydrophobic
A140 3.53x53 TM3 Q384 G.H5.16 van-der-waals
I141 3.54x54 TM3 L388 G.H5.20 hydrophobic
T253 - ICL3 T319 G.hgh4.09 polar
T253 - ICL3 T319 G.hgh4.09 hydrophobic
T253 - ICL3 T319 G.hgh4.09 van-der-waals
V237 5.70x70 TM5 E322 G.hgh4.12 hydrophobic
V237 5.70x70 TM5 E322 G.hgh4.12 van-der-waals
Y148 34.54x54 ICL2 I383 G.H5.15 polar
Y148 34.54x54 ICL2 I383 G.H5.15 hydrophobic
Y148 34.54x54 ICL2 I383 G.H5.15 van-der-waals
T253 - ICL3 D343 G.H4.13 polar
T253 - ICL3 D343 G.H4.13 hydrophobic
T253 - ICL3 D343 G.H4.13 van-der-waals
R149 34.55x55 ICL2 K216 G.s2s3.02 polar
R149 34.55x55 ICL2 K216 G.s2s3.02 hydrophobic
R149 34.55x55 ICL2 K216 G.s2s3.02 van-der-waals
S241 5.74x74 TM5 F340 G.H4.10 polar
G153 4.39x39 TM4 Q35 G.HN.52 polar
G153 4.39x39 TM4 Q35 G.HN.52 hydrophobic
G153 4.39x39 TM4 Q35 G.HN.52 van-der-waals
H150 34.56x56 ICL2 K216 G.s2s3.02 polar
H150 34.56x56 ICL2 K216 G.s2s3.02 hydrophobic
H150 34.56x56 ICL2 K216 G.s2s3.02 van-der-waals
R243 5.76x76 TM5 H362 G.S6.04 polar
R243 5.76x76 TM5 H362 G.S6.04 aromatic
R243 5.76x76 TM5 H362 G.S6.04 hydrophobic
R243 5.76x76 TM5 H362 G.S6.04 van-der-waals
R149 34.55x55 ICL2 V217 G.S3.01 polar
R149 34.55x55 ICL2 V217 G.S3.01 hydrophobic
R149 34.55x55 ICL2 V217 G.S3.01 van-der-waals
T253 - ICL3 Y318 G.hgh4.08 polar
T253 - ICL3 Y318 G.hgh4.08 hydrophobic
T253 - ICL3 Y318 G.hgh4.08 van-der-waals
S241 5.74x74 TM5 R342 G.H4.12 polar
S241 5.74x74 TM5 R342 G.H4.12 hydrophobic
S241 5.74x74 TM5 R342 G.H4.12 van-der-waals
I276 6.40x40 TM6 L393 G.H5.25 hydrophobic
I276 6.40x40 TM6 L393 G.H5.25 van-der-waals
Y148 34.54x54 ICL2 A39 G.hns1.03 polar
Y148 34.54x54 ICL2 A39 G.hns1.03 hydrophobic
Y148 34.54x54 ICL2 A39 G.hns1.03 van-der-waals
L146 34.52x52 ICL2 D215 G.s2s3.01 hydrophobic
L146 34.52x52 ICL2 D215 G.s2s3.01 van-der-waals
S329 8.47x47 H8 Y391 G.H5.23 hydrophobic
R248 - ICL3 E322 G.hgh4.12 polar
R248 - ICL3 E322 G.hgh4.12 hydrophobic
R248 - ICL3 E322 G.hgh4.12 van-der-waals
A140 3.53x53 TM3 R380 G.H5.12 van-der-waals
R249 - ICL3 P321 G.hgh4.11 polar
R249 - ICL3 P321 G.hgh4.11 hydrophobic
R249 - ICL3 P321 G.hgh4.11 van-der-waals
L146 34.52x52 ICL2 K216 G.s2s3.02 hydrophobic
L146 34.52x52 ICL2 K216 G.s2s3.02 van-der-waals
A147 34.53x53 ICL2 A39 G.hns1.03 hydrophobic
A147 34.53x53 ICL2 A39 G.hns1.03 van-der-waals
F328 7.56x56 TM7 L393 G.H5.25 hydrophobic
F328 7.56x56 TM7 L393 G.H5.25 van-der-waals
G239 5.72x72 TM5 R342 G.H4.12 hydrophobic
G239 5.72x72 TM5 R342 G.H4.12 van-der-waals
F328 7.56x56 TM7 E392 G.H5.24 hydrophobic
E242 5.75x75 TM5 E322 G.hgh4.12 polar
E242 5.75x75 TM5 E322 G.hgh4.12 hydrophobic
E242 5.75x75 TM5 E322 G.hgh4.12 van-der-waals
S152 4.38x38 TM4 Q35 G.HN.52 polar
S152 4.38x38 TM4 Q35 G.HN.52 hydrophobic
S152 4.38x38 TM4 Q35 G.HN.52 van-der-waals
S152 4.38x38 TM4 A39 G.hns1.03 polar
S152 4.38x38 TM4 A39 G.hns1.03 hydrophobic
S152 4.38x38 TM4 A39 G.hns1.03 van-der-waals
G153 4.39x39 TM4 V36 G.HN.53 hydrophobic
G254 - ICL3 R342 G.H4.12 hydrophobic
G254 - ICL3 R342 G.H4.12 van-der-waals
V76 2.41x41 TM2 R38 G.hns1.02 van-der-waals
R249 - ICL3 T320 G.hgh4.10 polar
R249 - ICL3 T320 G.hgh4.10 hydrophobic
R249 - ICL3 T320 G.hgh4.10 van-der-waals
M133 3.46x46 TM3 L394 G.H5.26 hydrophobic
M133 3.46x46 TM3 L394 G.H5.26 van-der-waals
R243 5.76x76 TM5 P361 G.S6.03 polar
R243 5.76x76 TM5 P361 G.S6.03 hydrophobic
R243 5.76x76 TM5 P361 G.S6.03 van-der-waals
E258 - ICL3 L346 G.H4.16 hydrophobic
E258 - ICL3 L346 G.H4.16 van-der-waals
I78 2.43x43 TM2 Y391 G.H5.23 hydrophobic
R143 3.56x56 TM3 F376 G.H5.08 hydrophobic
T253 - ICL3 T320 G.hgh4.10 polar
T253 - ICL3 T320 G.hgh4.10 hydrophobic
T253 - ICL3 T320 G.hgh4.10 van-der-waals
P73 2.38x38 TM2 R38 G.hns1.02 hydrophobic
P73 2.38x38 TM2 R38 G.hns1.02 van-der-waals
Y148 34.54x54 ICL2 N218 G.S3.02 polar
Y148 34.54x54 ICL2 N218 G.S3.02 hydrophobic
Y148 34.54x54 ICL2 N218 G.S3.02 van-der-waals
P244 - ICL3 D323 G.hgh4.13 polar
P244 - ICL3 D323 G.hgh4.13 van-der-waals
M145 34.51x51 ICL2 V375 G.H5.07 hydrophobic
M145 34.51x51 ICL2 V375 G.H5.07 van-der-waals
G250 - ICL3 R342 G.H4.12 polar
G250 - ICL3 R342 G.H4.12 van-der-waals
G246 - ICL3 A324 G.hgh4.14 polar
G246 - ICL3 A324 G.hgh4.14 hydrophobic
G246 - ICL3 A324 G.hgh4.14 van-der-waals
G254 - ICL3 Y318 G.hgh4.08 hydrophobic
G254 - ICL3 Y318 G.hgh4.08 van-der-waals
R143 3.56x56 TM3 R380 G.H5.12 hydrophobic
M145 34.51x51 ICL2 V214 G.S2.08 hydrophobic
Y148 34.54x54 ICL2 H41 G.S1.02 polar
Y148 34.54x54 ICL2 H41 G.S1.02 aromatic
Y148 34.54x54 ICL2 H41 G.S1.02 hydrophobic
Y148 34.54x54 ICL2 H41 G.S1.02 van-der-waals
S152 4.38x38 TM4 T40 G.S1.01 polar
S152 4.38x38 TM4 T40 G.S1.01 hydrophobic
S152 4.38x38 TM4 T40 G.S1.01 van-der-waals
H155 4.41x41 TM4 K32 G.HN.49 hydrophobic
P144 34.50x50 ICL2 R380 G.H5.12 hydrophobic
P144 34.50x50 ICL2 R380 G.H5.12 van-der-waals
G151 34.57x57 ICL2 T40 G.S1.01 hydrophobic
T273 6.37x37 TM6 L394 G.H5.26 hydrophobic
I228 5.61x61 TM5 Q384 G.H5.16 hydrophobic
I228 5.61x61 TM5 Q384 G.H5.16 van-der-waals
S152 4.38x38 TM4 Y37 G.hns1.01 polar
S152 4.38x38 TM4 Y37 G.hns1.01 hydrophobic
S152 4.38x38 TM4 Y37 G.hns1.01 van-der-waals
R243 5.76x76 TM5 D378 G.H5.10 ionic
R243 5.76x76 TM5 D378 G.H5.10 polar
E231 5.64x64 TM5 D381 G.H5.13 hydrophobic
E231 5.64x64 TM5 D381 G.H5.13 van-der-waals
R247 - ICL3 E322 G.hgh4.12 hydrophobic
R247 - ICL3 E322 G.hgh4.12 van-der-waals
G239 5.72x72 TM5 P361 G.S6.03 hydrophobic
G239 5.72x72 TM5 P361 G.S6.03 van-der-waals
H70 - ICL1 Q31 G.HN.48 polar
Y148 34.54x54 ICL2 V217 G.S3.01 hydrophobic
Y148 34.54x54 ICL2 V217 G.S3.01 van-der-waals
S241 5.74x74 TM5 D343 G.H4.13 polar
F328 7.56x56 TM7 Y391 G.H5.23 hydrophobic
F328 7.56x56 TM7 Y391 G.H5.23 van-der-waals
I228 5.61x61 TM5 L388 G.H5.20 hydrophobic
S241 5.74x74 TM5 Y339 G.H4.08 polar
S241 5.74x74 TM5 Y339 G.H4.08 hydrophobic
S241 5.74x74 TM5 Y339 G.H4.08 van-der-waals
G250 - ICL3 P321 G.hgh4.11 polar
G250 - ICL3 P321 G.hgh4.11 hydrophobic
G250 - ICL3 P321 G.hgh4.11 van-der-waals
G254 - ICL3 P321 G.hgh4.11 hydrophobic
G254 - ICL3 P321 G.hgh4.11 van-der-waals
H261 6.25x25 TM6 A351 G.h4s6.04 polar
H261 6.25x25 TM6 A351 G.h4s6.04 hydrophobic
H261 6.25x25 TM6 A351 G.h4s6.04 van-der-waals