Refined structure (7E2Z) of Gi1 - 5-HT1A receptor

RECEPTOR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-19

3D VIEW

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Structure (7E2Z)
Model (AlphaFold2-Multimer)

REFINED G PROTEIN RESIDUES

Residue backbones - 219 from structure (61.9%), 135 from model (38.1%)
Residue sidechains - 215 from structure (60.7%), 139 from model (39.3%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 278 from structure (80.3%), 68 from model (19.7%)
Residue sidechains - 277 from structure (80.1%), 69 from model (19.9%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 V - AF2 AF2
N-term 4 L - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 P - AF2 AF2
N-term 7 G - AF2 AF2
N-term 8 Q - AF2 AF2
N-term 9 G - AF2 AF2
N-term 10 N - AF2 AF2
N-term 11 N - AF2 AF2
N-term 12 T - AF2 AF2
N-term 13 T - AF2 AF2
N-term 14 S - AF2 AF2
N-term 15 P - AF2 AF2
N-term 16 P - AF2 AF2
N-term 17 A - AF2 AF2
N-term 18 P - AF2 AF2
N-term 19 F - AF2 AF2
N-term 20 E - AF2 AF2
N-term 21 T - AF2 AF2
N-term 22 G - AF2 AF2
N-term 23 G - AF2 AF2
N-term 24 N - AF2 AF2
N-term 25 T - AF2 AF2
N-term 26 T - AF2 AF2
N-term 27 G - AF2 AF2
N-term 28 I - AF2 AF2
N-term 29 S - AF2 AF2
N-term 30 D - AF2 AF2
N-term 31 V - AF2 AF2
TM1 32 T 1.28x28 AF2 AF2
TM1 33 V 1.29x29 AF2 AF2
TM1 34 S 1.30x30 AF2 AF2
TM1 35 Y 1.31x31 Structure Structure
TM1 36 Q 1.32x32 Structure Structure
TM1 37 V 1.33x33 Structure Structure
TM1 38 I 1.34x34 Structure Structure
TM1 39 T 1.35x35 Structure Structure
TM1 40 S 1.36x36 Structure Structure
TM1 41 L 1.37x37 Structure Structure
TM1 42 L 1.38x38 Structure Structure
TM1 43 L 1.39x39 Structure Structure
TM1 44 G 1.40x40 Structure Structure
TM1 45 T 1.41x41 Structure Structure
TM1 46 L 1.42x42 Structure Structure
TM1 47 I 1.43x43 Structure Structure
TM1 48 F 1.44x44 Structure Structure
TM1 49 C 1.45x45 Structure Structure
TM1 50 A 1.46x46 Structure Structure
TM1 51 V 1.47x47 Structure Structure
TM1 52 L 1.48x48 Structure Structure
TM1 53 G 1.49x49 Structure Structure
TM1 54 N 1.50x50 Structure Structure
TM1 55 A 1.51x51 Structure Structure
TM1 56 C 1.52x52 Structure Structure
TM1 57 V 1.53x53 Structure Structure
TM1 58 V 1.54x54 Structure Structure
TM1 59 A 1.55x55 Structure Structure
TM1 60 A 1.56x56 Structure Structure
TM1 61 I 1.57x57 Structure Structure
TM1 62 A 1.58x58 Structure Structure
TM1 63 L 1.59x59 Structure Structure
TM1 64 E 1.60x60 Structure Structure
ICL1 65 R 12.48x48 Structure Structure
ICL1 66 S 12.49x49 Structure Structure
ICL1 67 L 12.50x50 Structure Structure
ICL1 68 Q 12.51x51 Structure Structure
TM2 69 N 2.37x37 Structure Structure
TM2 70 V 2.38x38 Structure Structure
TM2 71 A 2.39x39 Structure Structure
TM2 72 N 2.40x40 Structure Structure
TM2 73 Y 2.41x41 Structure Structure
TM2 74 L 2.42x42 Structure Structure
TM2 75 I 2.43x43 Structure Structure
TM2 76 G 2.44x44 Structure Structure
TM2 77 S 2.45x45 Structure Structure
TM2 78 L 2.46x46 Structure Structure
TM2 79 A 2.47x47 Structure Structure
TM2 80 V 2.48x48 Structure Structure
TM2 81 T 2.49x49 Structure Structure
TM2 82 D 2.50x50 Structure Structure
TM2 83 L 2.51x51 Structure Structure
TM2 84 M 2.52x52 Structure Structure
TM2 85 V 2.53x53 Structure Structure
TM2 86 S 2.54x54 Structure Structure
TM2 87 V 2.55x55 Structure Structure
TM2 88 L 2.56x551 Structure Structure
TM2 89 V 2.57x56 Structure Structure
TM2 90 L 2.58x57 Structure Structure
TM2 91 P 2.59x58 Structure Structure
TM2 92 M 2.60x59 Structure Structure
TM2 93 A 2.61x60 Structure Structure
TM2 94 A 2.62x61 Structure Structure
TM2 95 L 2.63x62 Structure Structure
TM2 96 Y 2.64x63 Structure Structure
TM2 97 Q 2.65x64 Structure Structure
TM2 98 V 2.66x65 Structure Structure
TM2 99 L 2.67x66 Structure Structure
TM2 100 N 2.68x67 Structure Structure
ECL1 101 K 23.49x49 Structure Structure
ECL1 102 W 23.50x50 Structure Structure
ECL1 103 T 23.51x51 Structure Structure
ECL1 104 L 23.52x52 Structure Structure
TM3 105 G 3.21x21 Structure Structure
TM3 106 Q 3.22x22 Structure Structure
TM3 107 V 3.23x23 Structure Structure
TM3 108 T 3.24x24 Structure Structure
TM3 109 C 3.25x25 Structure Structure
TM3 110 D 3.26x26 Structure Structure
TM3 111 L 3.27x27 Structure Structure
TM3 112 F 3.28x28 Structure Structure
TM3 113 I 3.29x29 Structure Structure
TM3 114 A 3.30x30 Structure Structure
TM3 115 L 3.31x31 Structure Structure
TM3 116 D 3.32x32 Structure Structure
TM3 117 V 3.33x33 Structure Structure
TM3 118 L 3.34x34 Structure Structure
TM3 119 C 3.35x35 Structure Structure
TM3 120 C 3.36x36 Structure Structure
TM3 121 T 3.37x37 Structure Structure
TM3 122 S 3.38x38 Structure Structure
TM3 123 S 3.39x39 Structure Structure
TM3 124 I 3.40x40 Structure Structure
TM3 125 L 3.41x41 Structure AF2
TM3 126 H 3.42x42 Structure Structure
TM3 127 L 3.43x43 Structure Structure
TM3 128 C 3.44x44 Structure Structure
TM3 129 A 3.45x45 Structure Structure
TM3 130 I 3.46x46 Structure Structure
TM3 131 A 3.47x47 Structure Structure
TM3 132 L 3.48x48 Structure Structure
TM3 133 D 3.49x49 Structure Structure
TM3 134 R 3.50x50 Structure Structure
TM3 135 Y 3.51x51 Structure Structure
TM3 136 W 3.52x52 Structure Structure
TM3 137 A 3.53x53 Structure Structure
TM3 138 I 3.54x54 Structure Structure
TM3 139 T 3.55x55 Structure Structure
TM3 140 D 3.56x56 Structure Structure
ICL2 141 P 34.50x50 Structure Structure
ICL2 142 I 34.51x51 Structure Structure
ICL2 143 D 34.52x52 Structure Structure
ICL2 144 Y 34.53x53 Structure Structure
ICL2 145 V 34.54x54 Structure Structure
ICL2 146 N 34.55x55 Structure Structure
ICL2 147 K 34.56x56 Structure Structure
ICL2 148 R 34.57x57 Structure Structure
TM4 149 T 4.38x38 Structure Structure
TM4 150 P 4.39x39 Structure Structure
TM4 151 R 4.40x40 Structure Structure
TM4 152 R 4.41x41 Structure Structure
TM4 153 A 4.42x42 Structure Structure
TM4 154 A 4.43x43 Structure Structure
TM4 155 A 4.44x44 Structure Structure
TM4 156 L 4.45x45 Structure Structure
TM4 157 I 4.46x46 Structure Structure
TM4 158 S 4.47x47 Structure Structure
TM4 159 L 4.48x48 Structure Structure
TM4 160 T 4.49x49 Structure Structure
TM4 161 W 4.50x50 Structure Structure
TM4 162 L 4.51x51 Structure Structure
TM4 163 I 4.52x52 Structure Structure
TM4 164 G 4.53x53 Structure Structure
TM4 165 F 4.54x54 Structure Structure
TM4 166 L 4.55x55 Structure Structure
TM4 167 I 4.56x56 Structure Structure
TM4 168 S 4.57x57 Structure Structure
TM4 169 I 4.58x58 Structure Structure
TM4 170 P 4.59x59 Structure Structure
TM4 171 P 4.60x60 Structure Structure
TM4 172 M 4.61x61 Structure Structure
TM4 173 L 4.62x62 Structure Structure
TM4 174 G 4.63x63 Structure Structure
TM4 175 W 4.64x64 Structure Structure
ECL2 176 R - AF2 AF2
ECL2 177 T - AF2 AF2
ECL2 178 P - AF2 AF2
ECL2 179 E - AF2 AF2
ECL2 180 D - AF2 AF2
ECL2 181 R - AF2 AF2
ECL2 182 S - AF2 AF2
ECL2 183 D - AF2 AF2
ECL2 184 P - Structure Structure
ECL2 185 D - Structure Structure
ECL2 186 A - Structure Structure
ECL2 187 C 45.50x50 Structure Structure
ECL2 188 T 45.51x51 Structure Structure
ECL2 189 I 45.52x52 Structure Structure
ECL2 190 S - Structure Structure
ECL2 191 K - Structure Structure
TM5 192 D 5.35x36 Structure Structure
TM5 193 H 5.36x37 Structure Structure
TM5 194 G 5.37x38 Structure Structure
TM5 195 Y 5.38x39 Structure Structure
TM5 196 T 5.39x40 Structure Structure
TM5 197 I 5.40x41 Structure Structure
TM5 198 Y 5.41x42 Structure Structure
TM5 199 S 5.42x43 Structure Structure
TM5 200 T 5.43x44 Structure Structure
TM5 201 F 5.44x45 Structure Structure
TM5 202 G 5.45x46 Structure Structure
TM5 203 A 5.46x461 Structure Structure
TM5 204 F 5.47x47 Structure Structure
TM5 205 Y 5.48x48 Structure Structure
TM5 206 I 5.49x49 Structure Structure
TM5 207 P 5.50x50 Structure Structure
TM5 208 L 5.51x51 Structure Structure
TM5 209 L 5.52x52 Structure Structure
TM5 210 L 5.53x53 Structure Structure
TM5 211 M 5.54x54 Structure Structure
TM5 212 L 5.55x55 Structure Structure
TM5 213 V 5.56x56 Structure Structure
TM5 214 L 5.57x57 Structure Structure
TM5 215 Y 5.58x58 Structure Structure
TM5 216 G 5.59x59 Structure Structure
TM5 217 R 5.60x60 Structure Structure
TM5 218 I 5.61x61 Structure Structure
TM5 219 F 5.62x62 Structure Structure
TM5 220 R 5.63x63 Structure Structure
TM5 221 A 5.64x64 Structure Structure
TM5 222 A 5.65x65 Structure Structure
TM5 223 R 5.66x66 Structure Structure
TM5 224 F 5.67x67 Structure Structure
TM5 225 R 5.68x68 Structure Structure
TM5 226 I 5.69x69 Structure Structure
TM5 227 R 5.70x70 Structure Structure
TM5 228 K 5.71x71 Structure Structure
TM5 229 T 5.72x72 AF2 AF2
TM5 230 V 5.73x73 AF2 AF2
TM5 231 K 5.74x74 AF2 AF2
TM5 232 K 5.75x75 AF2 AF2
TM5 233 V 5.76x76 AF2 AF2
ICL3 234 E - AF2 AF2
ICL3 235 K - AF2 AF2
ICL3 236 T - AF2 AF2
ICL3 237 G - AF2 AF2
ICL3 238 A - AF2 AF2
ICL3 239 D - AF2 AF2
ICL3 240 T - AF2 AF2
ICL3 317 A - AF2 AF2
ICL3 318 P - AF2 AF2
ICL3 319 A - AF2 AF2
ICL3 320 S - AF2 AF2
ICL3 321 F - AF2 AF2
ICL3 322 E - AF2 AF2
ICL3 323 R - AF2 AF2
TM6 324 K 6.14x14 Structure Structure
TM6 325 N 6.15x15 Structure Structure
TM6 326 E 6.16x16 Structure Structure
TM6 327 R 6.17x17 Structure Structure
TM6 328 N 6.18x18 Structure Structure
TM6 329 A 6.19x19 Structure Structure
TM6 330 E 6.20x20 Structure Structure
TM6 331 A 6.21x21 Structure Structure
TM6 332 K 6.22x22 Structure Structure
TM6 333 R 6.23x23 Structure Structure
TM6 334 K 6.24x24 Structure Structure
TM6 335 M 6.25x25 Structure Structure
TM6 336 A 6.26x26 Structure Structure
TM6 337 L 6.27x27 Structure Structure
TM6 338 A 6.28x28 Structure Structure
TM6 339 R 6.29x29 Structure Structure
TM6 340 E 6.30x30 Structure Structure
TM6 341 R 6.31x31 Structure Structure
TM6 342 K 6.32x32 Structure Structure
TM6 343 T 6.33x33 Structure Structure
TM6 344 V 6.34x34 Structure Structure
TM6 345 K 6.35x35 Structure Structure
TM6 346 T 6.36x36 Structure Structure
TM6 347 L 6.37x37 Structure Structure
TM6 348 G 6.38x38 Structure Structure
TM6 349 I 6.39x39 Structure Structure
TM6 350 I 6.40x40 Structure Structure
TM6 351 M 6.41x41 Structure Structure
TM6 352 G 6.42x42 Structure Structure
TM6 353 T 6.43x43 Structure Structure
TM6 354 F 6.44x44 Structure Structure
TM6 355 I 6.45x45 Structure Structure
TM6 356 L 6.46x46 Structure Structure
TM6 357 C 6.47x47 Structure Structure
TM6 358 W 6.48x48 Structure Structure
TM6 359 L 6.49x49 Structure Structure
TM6 360 P 6.50x50 Structure Structure
TM6 361 F 6.51x51 Structure Structure
TM6 362 F 6.52x52 Structure Structure
TM6 363 I 6.53x53 Structure Structure
TM6 364 V 6.54x54 Structure Structure
TM6 365 A 6.55x55 Structure Structure
TM6 366 L 6.56x56 Structure Structure
TM6 367 V 6.57x57 Structure Structure
TM6 368 L 6.58x58 Structure Structure
TM6 369 P 6.59x59 Structure Structure
TM6 370 F 6.60x60 Structure Structure
TM6 371 C 6.61x61 Structure Structure
ECL3 372 E - Structure Structure
ECL3 373 S - Structure Structure
ECL3 374 S - Structure Structure
ECL3 375 C - Structure Structure
ECL3 376 H - Structure Structure
ECL3 377 M - Structure Structure
TM7 378 P 7.31x30 Structure Structure
TM7 379 T 7.32x31 Structure Structure
TM7 380 L 7.33x32 Structure Structure
TM7 381 L 7.34x33 Structure Structure
TM7 382 G 7.35x34 Structure Structure
TM7 383 A 7.36x35 Structure Structure
TM7 384 I 7.37x36 Structure Structure
TM7 385 I 7.38x37 Structure Structure
TM7 386 N 7.39x38 Structure Structure
TM7 387 W 7.40x39 Structure Structure
TM7 388 L 7.41x40 Structure Structure
TM7 389 G 7.42x41 Structure Structure
TM7 390 Y 7.43x42 Structure Structure
TM7 391 S 7.44x43 Structure Structure
TM7 392 N 7.45x45 Structure Structure
TM7 393 S 7.46x46 Structure Structure
TM7 394 L 7.47x47 Structure Structure
TM7 395 L 7.48x48 Structure Structure
TM7 396 N 7.49x49 Structure Structure
TM7 397 P 7.50x50 Structure Structure
TM7 398 V 7.51x51 Structure Structure
TM7 399 I 7.52x52 Structure Structure
TM7 400 Y 7.53x53 Structure Structure
TM7 401 A 7.54x54 Structure Structure
TM7 402 Y 7.55x55 Structure Structure
TM7 403 F 7.56x56 Structure Structure
H8 404 N 8.47x47 Structure Structure
H8 405 K 8.48x48 Structure Structure
H8 406 D 8.49x49 Structure Structure
H8 407 F 8.50x50 Structure Structure
H8 408 Q 8.51x51 Structure Structure
H8 409 N 8.52x52 Structure Structure
H8 410 A 8.53x53 Structure Structure
H8 411 F 8.54x54 Structure Structure
H8 412 K 8.55x55 Structure Structure
H8 413 K 8.56x56 Structure Structure
H8 414 I 8.57x57 Structure Structure
H8 415 I 8.58x58 Structure Structure
C-term 416 K - AF2 AF2
C-term 417 C - AF2 AF2
C-term 418 K - AF2 AF2
C-term 419 F - AF2 AF2
C-term 420 C - AF2 AF2
C-term 421 R - AF2 AF2
C-term 422 Q - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

NGL is a WebGL based 3D viewer powered by MMTF.

GPCR Amino Acid GPCRdb# Segment G protein Amino Acid CGN# Interaction Type
I138 3.54x54 TM3 L353 G.H5.25 hydrophobic
I138 3.54x54 TM3 C351 G.H5.23 hydrophobic
P141 34.50x50 ICL2 T340 G.H5.12 hydrophobic
P141 34.50x50 ICL2 T340 G.H5.12 van-der-waals
I138 3.54x54 TM3 I344 G.H5.16 van-der-waals
V145 34.54x54 ICL2 I343 G.H5.15 hydrophobic
V145 34.54x54 ICL2 I343 G.H5.15 van-der-waals
Y144 34.53x53 ICL2 I343 G.H5.15 hydrophobic
K147 34.56x56 ICL2 D193 G.s2s3.02 ionic
I218 5.61x61 TM5 L353 G.H5.25 hydrophobic
I218 5.61x61 TM5 L353 G.H5.25 van-der-waals
T346 6.36x36 TM6 L353 G.H5.25 hydrophobic
R225 5.68x68 TM5 D341 G.H5.13 ionic
R225 5.68x68 TM5 D341 G.H5.13 polar
R225 5.68x68 TM5 D341 G.H5.13 hydrophobic
R225 5.68x68 TM5 D341 G.H5.13 van-der-waals
F321 - ICL3 Q306 G.H4.14 hydrophobic
F321 - ICL3 Q306 G.H4.14 van-der-waals
V145 34.54x54 ICL2 R32 G.hns1.03 hydrophobic
Y144 34.53x53 ICL2 N347 G.H5.19 polar
Y144 34.53x53 ICL2 N347 G.H5.19 hydrophobic
Y144 34.53x53 ICL2 N347 G.H5.19 van-der-waals
T236 - ICL3 C305 G.H4.13 polar
F321 - ICL3 C305 G.H4.13 hydrophobic
F321 - ICL3 C305 G.H4.13 van-der-waals
I226 5.69x69 TM5 F354 G.H5.26 hydrophobic
N146 34.55x55 ICL2 R32 G.hns1.03 hydrophobic
N146 34.55x55 ICL2 R32 G.hns1.03 van-der-waals
A137 3.53x53 TM3 N347 G.H5.19 polar
A137 3.53x53 TM3 N347 G.H5.19 van-der-waals
K232 5.75x75 TM5 Y320 G.S6.02 van-der-waals
I138 3.54x54 TM3 L348 G.H5.20 hydrophobic
T236 - ICL3 Q304 G.H4.12 hydrophobic
T236 - ICL3 Q304 G.H4.12 van-der-waals
T346 6.36x36 TM6 G352 G.H5.24 polar
P141 34.50x50 ICL2 I344 G.H5.16 hydrophobic
P318 - ICL3 Y290 G.hgh4.05 hydrophobic
P318 - ICL3 Y290 G.hgh4.05 van-der-waals
T229 5.72x72 TM5 E318 G.h4s6.12 polar
T229 5.72x72 TM5 E318 G.h4s6.12 hydrophobic
T229 5.72x72 TM5 E318 G.h4s6.12 van-der-waals
R225 5.68x68 TM5 I344 G.H5.16 hydrophobic
R225 5.68x68 TM5 I344 G.H5.16 van-der-waals
K342 6.32x32 TM6 G352 G.H5.24 hydrophobic
K342 6.32x32 TM6 G352 G.H5.24 van-der-waals
N146 34.55x55 ICL2 D193 G.s2s3.02 polar
P141 34.50x50 ICL2 I343 G.H5.15 hydrophobic
R225 5.68x68 TM5 L348 G.H5.20 hydrophobic
K228 5.71x71 TM5 D341 G.H5.13 ionic
K228 5.71x71 TM5 D341 G.H5.13 polar
K228 5.71x71 TM5 D341 G.H5.13 van-der-waals
T343 6.33x33 TM6 F354 G.H5.26 polar
P318 - ICL3 A291 G.hgh4.06 hydrophobic
P318 - ICL3 A291 G.hgh4.06 van-der-waals
R134 3.50x50 TM3 C351 G.H5.23 hydrophobic
R134 3.50x50 TM3 C351 G.H5.23 van-der-waals
A317 - ICL3 E298 G.H4.05 polar
A317 - ICL3 E298 G.H4.05 hydrophobic
A317 - ICL3 E298 G.H4.05 van-der-waals
F321 - ICL3 Y302 G.H4.10 aromatic
F321 - ICL3 Y302 G.H4.10 hydrophobic
F321 - ICL3 Y302 G.H4.10 van-der-waals
A222 5.65x65 TM5 L348 G.H5.20 hydrophobic
K342 6.32x32 TM6 F354 G.H5.26 hydrophobic
V145 34.54x54 ICL2 L194 G.S3.01 hydrophobic
R339 6.29x29 TM6 F354 G.H5.26 hydrophobic
R339 6.29x29 TM6 F354 G.H5.26 van-der-waals
N328 6.18x18 TM6 D309 G.H4.17 polar
I142 34.51x51 ICL2 F336 G.H5.08 hydrophobic
R339 6.29x29 TM6 D315 G.h4s6.09 polar
R339 6.29x29 TM6 D315 G.h4s6.09 van-der-waals
T240 - ICL3 S293 G.hgh4.08 hydrophobic
L347 6.37x37 TM6 L353 G.H5.25 hydrophobic
I138 3.54x54 TM3 N347 G.H5.19 hydrophobic
M335 6.25x25 TM6 D315 G.h4s6.09 hydrophobic
V145 34.54x54 ICL2 V34 G.S1.02 hydrophobic
T240 - ICL3 E298 G.H4.05 polar
T240 - ICL3 E298 G.H4.05 hydrophobic
T240 - ICL3 E298 G.H4.05 van-der-waals
T343 6.33x33 TM6 L353 G.H5.25 polar
T343 6.33x33 TM6 L353 G.H5.25 hydrophobic
T343 6.33x33 TM6 L353 G.H5.25 van-der-waals