Class A Aminergic 5-Hydroxytryptamine 5HT1A5HT1B5HT1D5HT1E5HT1F5HT2A5HT2B5HT2C5HT4R5HT5A5HT6R5HT7RAcetylcholine (musc.)ACM1ACM2ACM3ACM4ACM5AdrenoceptorsADA1AADA1BADA1DADA2AADA2BADA2CADRB1ADRB2ADRB3Dopamine DRD1DRD2DRD3DRD4DRD5Histamine HRH1HRH2HRH3HRH4TAAR1Peptide Angiotensin AGTR1AGTR2APJBombesin NMBRGRPRBRS3Bradykinin BKRB1BKRB2Cholecystokinin CCKARGASRComplement C3ARC5AR1C5AR2Endothelin EDNRAEDNRBFormylpeptide FPR1FPR2FPR3Galanin GALR1GALR2GALR3GHSRGNRHRKISSRMelanin-conc.MCHR1MCHR2Melanocortin MSHRACTHRMC3RMC4RMC5RMTLRNeuromedin U NMUR1NMUR2Neuropeptide FF/ AF NPFF1NPFF2NPSR1Neuropeptide W/ B NPBW1NPBW2Neuropeptide Y NPY1RNPY2RNPY4RNPY5RNPY6RNeurotensin NTR1NTR2Opioid OPRDOPRKOPRMOPRXOrexin OX1ROX2RQRFPRPRLHRProteinase-activated PAR1PAR2PAR3PAR4Relaxin family RXFP1RXFP2RL3R1RL3R2Somatostatin SSR1SSR2SSR3SSR4SSR5Tachykinin NK1RNK2RNK3RTRFRUR2RVasopressin/Oxytocin V1ARV1BRV2ROXYRProtein ChemerinCML1CML2Chemokine CCR1CCR2CCR3CCR4CCR5CCR6CCR7CCR8CCR9CCR10CXCR1CXCR2CXCR3CXCR4CXCR5CXCR6CX3C1XCR1ACKR1ACKR2ACKR3ACKR4CCRL2Glycoprotein FSHRLSHRTSHRProkineticin PKR1PKR2Lipid Free fatty acid FFAR1FFAR2FFAR3FFAR4GPR42Leukotriene LT4R1LT4R2CLTR1CLTR2OXER1Lysophospholipid LPAR1LPAR2LPAR3LPAR4LPAR5LPAR6Lysophospholipid S1PR1S1PR2S1PR3S1PR4S1PR5Cannabinoid CNR1CNR2GPR18/55/119GPR18GPR55GP119PTAFRProstanoid PD2RPD2R2PE2R1PE2R2PE2R3PE2R4PF2RPI2RTA2RMelatonin MelatoninMTR1AMTR1BNucleotide Adenosine AA1RAA2ARAA2BRAA3RP2Y P2RY1P2RY2P2RY4P2RY6P2Y11P2Y12P2Y13P2Y14Steroid GPBARGPER1Alicarboxylic acid Hydroxycarboxylic acid HCAR1HCAR2HCAR3OXGR1SUCR1Sensory OpsinsOPSDOPN3OPN4OPN5OPSBOPSGOPSROPSXClass B1 Peptide Calcitonin CALCRCALRLCorticotropin CRFR1CRFR2Glucagon familyGHRHRGIPRGLP1RGLP2RGLRSCTRParathyroid PTH1RPTH2RVIP and PACAP PACRVIPR1VIPR2Class B2 Adhesion ADGRLAGRL1AGRL2AGRL3AGRL4ADGREAGRE1AGRE2AGRE3AGRE4AGRE5ADGRAAGRA1AGRA2AGRA3ADGRCCELR1CELR2CELR3ADGRDAGRD1AGRD2ADGRFAGRF1AGRF2AGRF3AGRF4AGRF5ADGRBAGRB1AGRB2AGRB3ADGRGAGRG1AGRG2AGRG3AGRG4AGRG5AGRG6AGRG7AGRV1Class C Ion CASRAmino acid GABAGABR1GABR2Metabotropic glutamate GRM1GRM2GRM3GRM4GRM5GRM6GRM7GRM8Sensory Taste 1 TS1R1TS1R2TS1R3Orphan Class C OrphansGP156GP158GP179RAI3GPC5BGPC5CGPC5DGPC6AClass F Protein FrizzledFZD1FZD2FZD3FZD4FZD5FZD6FZD7FZD8FZD9FZD10SMOClass O1 Odorant Odorant family 51O51A2O51A4O51A7O51B2O51B4O51B5O51B6O51D1O51E1O51E2O51F1O51F2O51G1O51G2O51H1O51I1O51I2O51J1O51L1O51M1O51Q1O51S1O51T1O51V1Odorant family 52O52A1O52A5O52B2O52B4O52B6O52D1O52E1O52E2O52E4O52E5O52E6O52E8O52H1O52I1O52I2O52J3O52K1O52K2O52L1O52M1O52N1O52N2O52N4O52N5O52P1O52R1O52W1Odorant family 56O56A1O56A3O56A4O56A5O56B1O56B4Class O2 Odorant Odorant family 1OR1A1OR1A2OR1B1OR1C1OR1D2OR1D4OR1D5OR1E1OR1E2OR1E3OR1F1OR1G1OR1I1OR1J1OR1J2OR1J4OR1K1OR1L1OR1L3OR1L4OR1L6OR1L8OR1M1OR1N1OR1N2OR1P1OR1Q1OR1S1OR1S2Odorant family 2OR2A1OR2A2OR2A4OR2A5OR2A7O2A12O2A14O2A25O2AE1O2AG1O2AG2O2AJ1O2AK2O2AP1O2AT4OR2B2OR2B3OR2B6OR2BBOR2C1OR2C3OR2D2OR2D3OR2F1OR2F2OR2G2OR2G3OR2G6OR2H1OR2H2OR2J1OR2J2OR2J3OR2K2OR2L2OR2L3OR2L5OR2L8OR2LDOR2M2OR2M3OR2M4OR2M5OR2M7OR2S1OR2T1OR2T2OR2T3OR2T4OR2T5OR2T6OR2T7OR2T8O2T10O2T11O2T12O2T27O2T29O2T33O2T34O2T35OR2V1OR2V2OR2W1OR2W3OR2Y1OR2Z1Odorant family 3OR3A1OR3A2OR3A3Odorant family 4OR4A5OR4A8O4A15O4A16O4A47OR4B1OR4C3OR4C5OR4C6OR4CBOR4CCOR4CDOR4CFOR4CGO4C45O4C46OR4D1OR4D2OR4D5OR4D6OR4D9OR4DAOR4DBOR4E1OR4E2OR4F3OR4F4OR4F5OR4F6O4F15O4F17O4F21OR4K1OR4K2OR4K3OR4K5OR4KDOR4KEOR4KFOR4KHOR4L1OR4M1OR4M2ORM2BOR4N2OR4N4ORN4COR4N5OR4P4OR4Q2OR4Q3OR4S1OR4S2OR4X1OR4X2Odorant family 5OR5A1OR5A2O5AC1O5AC2O5AK2O5AL1O5AN1O5AP2O5AR1O5AS1O5AU1OR5B2OR5B3OR5BCOR5BHO5B21OR5C1OR5DDOR5DEOR5DGOR5DIOR5F1OR5G3OR5H1OR5H2OR5H6OR5H8O5H14O5H15OR5I1OR5J2OR5K1OR5K2OR5K3OR5K4OR5L1OR5L2OR5M1OR5M3OR5M8OR5M9OR5MAOR5MBOR5P2OR5P3OR5T1OR5T2OR5T3OR5V1OR5W2Odorant family 6OR6A2OR6B1OR6B2OR6B3OR6C1OR6C2OR6C3OR6C4OR6C6O6C65O6C68O6C70O6C74O6C75O6C76OR6F1OR6J1OR6K2OR6K3OR6K6OR6M1OR6N1OR6N2OR6P1OR6Q1OR6S1OR6T1OR6V1OR6X1OR6Y1Odorant family 7OR7A5OR7AAOR7AHOR7C1OR7C2OR7D2OR7D4O7E24OR7G1OR7G2OR7G3Odorant family 8OR8A1OR8B2OR8B3OR8B4OR8B8OR8BCOR8D1OR8D2OR8D4OR8G1OR8G5OR8H1OR8H2OR8H3OR8I2OR8J1OR8J2OR8J3OR8K1OR8K3OR8K5OR8S1OR8U1OR5R1OR8U8OR8U9Odorant family 9OR9A2OR9A4OR9G1OR9G4OR9G9OR9I1OR9K2OR9Q1OR9Q2Odorant family 10O10A2O10A3O10A4O10A5O10A6O10A7O10ACO10ADO10AGO10C1O10D3O10G2O10G3O10G4O10G6O10G7O10G8O10G9O10H1O10H2O10H3O10H4O10H5O10J1O10J3O10J4O10J5O10K1O10K2O10P1O10Q1O10R2O10S1O10T2O10V1O10W1O10X1O10Z1Odorant family 11O11A1O11G2O11H1O11H2O11H4O11H6O11H7O11HCO11L1Odorant family 12O12D1O12D2O12D3Odorant family 13O13A1O13C2O13C3O13C4O13C5O13C7O13C8O13C9O13D1O13F1O13G1O13H1O13J1Odorant family 14O14A2O14AGO14CZO14I1O14J1O14K1O14L1Class T2 Sensory Taste 2 TA2R1TA2R3TA2R4TA2R5TA2R7TA2R8TA2R9T2R10T2R13T2R14T2R16T2R19T2R20T2R30T2R31T2R38T2R39T2R40T2R41T2R42T2R43T2R45T2R46T2R50T2R60
The classification tree highlights the number of unique isoforms detected for each receptor gene.
Non-reference isoforms included in this analysis preserve at least one TM segment of their reference GPCR.
The structural annotation table includes all the analysed non-reference isoforms.
Conserved, partially conserved, and non-conserved structural segments are coloured in green, orange, and red. Purple triangles indicate insertions.