Stabilising Mutation Analyser

Group by: Mutant Subsets: Only show mutations present in minimum 2 GPCRs
STATE TARGETS MUTATIONS FREQUENCY SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS
No. Receptor Families
No. Structures
PDBs Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A
1 1 4
4UHR, 4UG2, 2YDO, 2YDV
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N
1 1 1
5WF5
Pos Match 1
Active
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM2 2x52
A
L
2 1 28
5IU8, 3RFM, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 4UG2, 5OM4, 5NM4, 4UHR, 2YDV, 3UZC, 5MZJ, 2YDO, 5NLX, 3REY, 5N2S, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
1
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A
1 1 4
4UG2, 2YDO, 4UHR, 2YDV
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM3 3x36
T
A
2 1 24
5IU8, 3RFM, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 5N2S, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
42
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A
1 1 4
4UG2, 2YDO, 4UHR, 2YDV
16
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A
1 1 23
5IU8, 3RFM, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
1 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A
1 1 23
5IU8, 3RFM, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM5 5x63
L
Y
A
2 1 24
5IU8, 3RFM, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 5N2S, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
Active
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Peptide
Neurotensin
Adenosine
Dopamine
NTR1
AA1R
DRD2
AA2AR
A1
A2A
NTS1
D2
TM6 6x37
L
A
4 3 26
5IU8, 3RFM, 6CM4, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 5N2S, 3UZA, 4GRV, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
2 1 4
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Adenosine
Dopamine
AA1R
DRD2
AA2AR
A1
A2A
D2
TM6 6x41
L
V
A
3 2 25
5IU8, 3RFM, 6CM4, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 5N2S, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM7 7x41
T
S
A
2 1 24
5IU8, 3RFM, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 5N2S, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
12
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S
1 1 24
3ZPQ, 4AMI, 6H7L, 6IBL, 2Y02, 2Y00, 5F8U, 2YCX, 2YCZ, 2Y04, 3ZPR, 4GPO, 6H7N, 2VT4, 2Y03, 2Y01, 4AMJ, 4BVN, 5A8E, 2YCW, 6H7M, 6H7J, 2YCY, 6H7O
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V
1 1 25
3ZPQ, 4AMI, 6H7L, 6IBL, 2Y02, 2Y00, 5F8U, 2YCX, 2YCZ, 2Y04, 3ZPR, 4GPO, 6TKO, 6H7N, 2VT4, 2Y03, 2Y01, 4AMJ, 4BVN, 5A8E, 2YCW, 6H7M, 6H7J, 2YCY, 6H7O
4
Inactive
A (Rhodopsin)
Aminergic
Peptide
Apelin
Adrenoceptors
Dopamine
ADRB1
DRD2
APJ
apelin
β1
D2
TM3 3x40
I
V
V
A
3 3 4
5VBL, 6CM4, 4BVN, 5A8E
3
Intermediate
Active
Inactive
A (Rhodopsin)
Aminergic
Protein
Peptide
5-Hydroxytryptamine
Adrenoceptors
Neuropeptide Y
Dopamine
Chemokine
ADRB1
5HT1B
5HT2B
ADRB2
NPY1R
DRD3
CXCR4
5-HT1B
CXCR4
D3
β2
5-HT2B
Y1
β1
TM3 3x41
L
M
F
E
W
7 5 27
5TVN, 3NYA, 5TUD, 3D4S, 6DS0, 4IAQ, 3NY8, 6DRY, 4NC3, 3OE6, 5ZBH, 3OE8, 3OE0, 5ZBQ, 3ODU, 4IB4, 7C61, 3OE9, 5A8E, 4RWS, 3NY9, 3PBL, 6DRX, 6G79, 4IAR, 5V54, 6DRZ
3
Intermediate
Inactive
A (Rhodopsin)
Lipid
Aminergic
Adrenoceptors
Free fatty acid
ADRB1
FFAR1
FFA1
β1
TM5 5x58
Y
A
F
2 2 22
5KW2, 3ZPQ, 4AMI, 2Y02, 2Y00, 5TZY, 4PHU, 5F8U, 2YCX, 5TZR, 2YCZ, 2Y04, 4GPO, 2VT4, 2Y03, 2Y01, 4AMJ, 4BVN, 5A8E, 2YCW, 2YCY, 3ZPR
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L
1 1 18
2Y04, 3ZPQ, 4GPO, 4AMI, 2VT4, 2Y03, 2Y02, 2Y00, 2Y01, 4AMJ, 4BVN, 5A8E, 5F8U, 2YCW, 2YCX, 2YCZ, 2YCY, 3ZPR
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K
1 1 1
4BVN
16
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A
1 1 25
3ZPQ, 4AMI, 6H7L, 6IBL, 2Y02, 2Y00, 5F8U, 2YCX, 2YCZ, 2Y04, 3ZPR, 4GPO, 6TKO, 6H7N, 2VT4, 2Y03, 2Y01, 4AMJ, 4BVN, 5A8E, 2YCW, 6H7M, 6H7J, 2YCY, 6H7O
Active
Inactive
A (Rhodopsin)
Aminergic
Peptide
Endothelin
Adrenoceptors
ADRB1
EDNRB
ETB
β1
TM7 7x48
I
F
A
M
2 2 27
3ZPQ, 4AMI, 6H7L, 6IBL, 2Y02, 2Y00, 5F8U, 2YCX, 2YCZ, 2Y04, 3ZPR, 4GPO, 6TKO, 6H7N, 2VT4, 2Y03, 2Y01, 4AMJ, 4BVN, 5A8E, 2YCW, 6H7M, 6H7J, 5X93, 5XPR, 2YCY, 6H7O
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L
1 1 2
4BVN, 5A8E
Pos Match Pos Match 4
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C
1 1 2
3PDS, 4QKX
16
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K
1 1 1
5VBL
Pos Match 34
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y
1 1 5
7F1T, 6AKY, 6AKX, 4MBS, 5UIW
2
Active
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N
1 1 8
7F1T, 7F1Q, 6AKY, 6AKX, 7F1S, 4MBS, 7F1R, 5UIW
16
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D
1 1 5
7F1T, 6AKY, 6AKX, 4MBS, 5UIW
2 1 6
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E
1 1 5
7F1T, 6AKY, 6AKX, 4MBS, 5UIW
5 1 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A
1 1 1
5LWE
4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A
1 1 1
5LWE
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A
1 1 1
5LWE
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C
1 1 1
5LWE
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A
1 1 1
5LWE
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CXCR4
CXCR4
CCR9
TM6 6x36
T
V
A
P
2 1 4
3OE9, 5LWE, 4RWS, 3OE0
2 1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A
1 1 1
5LWE
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A
1 1 1
5LWE
8
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A
1 1 4
5XR8, 5TGZ, 5U09, 5XRA
1
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
Lysophospholipid (LPA)
LPAR1
CNR1
CB1
LPA1
TM5 5x37
E
D
C
K
2 2 4
4Z36, 5TGZ, 5XR8, 5XRA
2
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E
1 1 3
5TGZ, 5XR8, 5XRA
1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C
1 1 1
4RWS
30
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y
1 1 2
5XPR, 5X93
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A
1 1 1
5X93
5
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A
1 1 2
5XPR, 5X93
9
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A
1 1 2
5XPR, 5X93
5
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A
1 1 4
5KW2, 5TZY, 4PHU, 5TZR
4 1 1
Intermediate
A (Rhodopsin)
Lipid
Peptide
Free fatty acid
Proteinase-activated
PAR2
FFAR1
FFA1
PAR2
TM3 3x34
F
G
A
2 2 6
5KW2, 5NDD, 4PHU, 5NDZ, 5NJ6, 5TZR
1
Active
Intermediate
A (Rhodopsin)
Lipid
Peptide
Neurotensin
Free fatty acid
NTR1
FFAR1
FFA1
NTS1
TM3 3x49
E
G
A
2 2 6
5KW2, 5TZY, 4PHU, 5TZR, 4GRV, 4XES
Pos Match 2
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C
1 1 1
4Z36
7
Active
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L
1 1 12
4BWB, 4BUO, 3ZEV, 4XEE, 4GRV, 7L0P, 7L0S, 7L0R, 4BV0, 5T04, 4XES, 7L0Q
Active
Inactive
A (Rhodopsin)
Lipid
Sensory
Peptide
Neurotensin
Opsins
Leukotriene
NTR1
OPSD
Q9WTK1
OPSD
NTS1
BLT1
Rhodopsin
ECL2
D
N
G
S
C
A
4 3 25
5DYS, 6FK9, 6FKB, 5EN0, 5DGY, 4BEZ, 6FK6, 5T04, 6FK8, 4XES, 4A4M, 4BEY, 5W0P, 6FKC, 2J4Y, 2X72, 4GRV, 6FKA, 3C9M, 6FKD, 6CMO, 4XEE, 6FK7, 4ZWJ, 5X33
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A
1 1 4
3ZEV, 4BWB, 4BV0, 4BUO
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A
1 1 4
4XEE, 5T04, 4GRV, 4XES
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I
1 1 2
5DYS, 5EN0
31
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q
2 1 5
5W0P, 6CMO, 5DGY, 2X72, 4ZWJ
15
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y
2 1 5
4A4M, 5W0P, 6CMO, 5DGY, 4ZWJ
1 1
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2RY1
P2Y12
P2Y1
P2Y12
TM7 7x49
D
N
2 1 5
4PXZ, 4XNV, 4NTJ, 4XNW, 4PY0
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A
1 1 3
5NDD, 5NJ6, 5NDZ
1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A
1 1 3
5NDD, 5NJ6, 5NDZ
3 1 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L
1 1 3
5NDD, 5NJ6, 5NDZ
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A
1 1 3
5NDD, 5NJ6, 5NDZ
1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E
1 1 3
5NDD, 5NJ6, 5NDZ
5
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A
1 1 3
5NDD, 5NJ6, 5NDZ
1 3
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A
1 1 3
5NDD, 5NJ6, 5NDZ
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A
1 1 3
5NDD, 5NJ6, 5NDZ
Other
Intermediate
A (Rhodopsin)
Lipid
Platelet-activating factor
PTAFR
PAF
TM6 6x34
A
D
1 1 2
5ZKQ, 5ZKP
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G
1 1 1
5X33
1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G
1 1 1
5X33
1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A
1 1 1
5X33
1 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A
1 1 2
4Z9G, 4K5Y
5
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A
1 1 2
4Z9G, 4K5Y
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A
1 1 2
4K5Y, 4Z9G
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLR
CRFR1
CRF1
glucagon
TM2 2x48
A
S
L
A
2 2 3
4K5Y, 5EE7, 4Z9G
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A
1 1 2
4K5Y, 4Z9G
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLP1R
CRFR1
CRF1
GLP-1
ECL2 45x52
T
F
A
2 2 3
4K5Y, 5NX2, 4Z9G
14
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A
1 1 2
4K5Y, 4Z9G
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLP1R
GLR
CRFR1
CRF1
glucagon
GLP-1
TM6 6x30
K
Y
A
3 2 5
5EE7, 4Z9G, 5VEX, 5VEW, 4K5Y
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A
1 1 2
4K5Y, 4Z9G
2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A
1 1 2
4K5Y, 4Z9G
11
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A
1 1 2
4K5Y, 4Z9G
Pos Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM2 2x56
S
A
C
2 1 3
5VEX, 5EE7, 5VEW
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM2 2x59
I
V
F
2 1 3
5VEX, 5EE7, 5VEW
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
ECL1
L
D
Q
G
T
A
F
R
E
2 1 2
5EE7, 5NX2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM3 3x24
S
G
A
2 1 3
5VEX, 5EE7, 5VEW
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C
1 1 2
5VEX, 5VEW
8
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A
1 1 2
5VEX, 5VEW
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C
1 1 2
5VEX, 5VEW
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I
1 1 2
5VEX, 5VEW
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F
1 1 2
5VEX, 5VEW
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A
1 1 1
5NX2
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C
A
1 1 3
5VEX, 5NX2, 5VEW
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V
1 1 1
5NX2
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A
1 1 1
5NX2
2 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A
1 1 1
5EE7
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A
1 1 2
5EE7, 5YQZ
2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A
1 1 1
5EE7
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F
1 1 1
5EE7
2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A
1 1 1
5EE7
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A
1 1 5
6FFH, 5CGC, 6FFI, 5CGD, 4OO9
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y
1 1 5
6FFH, 5CGC, 6FFI, 5CGD, 4OO9
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A
1 1 5
6FFH, 5CGC, 6FFI, 5CGD, 4OO9
Pos Match
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M
1 1 5
6FFH, 5CGC, 6FFI, 5CGD, 4OO9
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A
1 1 5
6FFH, 5CGC, 6FFI, 5CGD, 4OO9
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A
1 1 5
6FFH, 5CGC, 6FFI, 5CGD, 4OO9
1
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F
1 1 2
5L7D, 5L7I
1
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N
1 1 2
6BQH, 6BQG
Pos Match 1
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A
1 1 1
5WF6
Pos Match 1
STATE TARGETS MUTATIONS FREQUENCY DATA (MUTANT) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A 1 1 4
4UHR, 4UG2, 2YDO, 2YDV
0 0.50
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N 1 1 1
5WF5
0.03 0.65 0.85 Pos & AA Mutant Match 1
Active
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM2 2x52
A
L 2 1 28
5IU8, 3RFM, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 4UG2, 5OM4, 5NM4, 4UHR, 2YDV, 3UZC, 5MZJ, 2YDO, 5NLX, 3REY, 5N2S, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
0.63 0.21 -1.25 1
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A 1 1 4
4UG2, 2YDO, 4UHR, 2YDV
0.14 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM3 3x36
T
A 2 1 24
5IU8, 3RFM, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 5N2S, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
0.02 0 0.50 42
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A 1 1 4
4UG2, 2YDO, 4UHR, 2YDV
0.03 0 0.50 16
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A 1 1 23
5IU8, 3RFM, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
0.08 0 0.50 1 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A 1 1 23
5IU8, 3RFM, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
0.13 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM5 5x63
L
Y
A 2 1 24
5IU8, 3RFM, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 5N2S, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
0.05 0 0.50
Active
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Peptide
Neurotensin
Adenosine
Dopamine
NTR1
AA1R
DRD2
AA2AR
A1
A2A
NTS1
D2
TM6 6x37
L
A 4 3 26
5IU8, 3RFM, 6CM4, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 5N2S, 3UZA, 4GRV, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
0.04 0 0.50 2 1 4
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Adenosine
Dopamine
AA1R
DRD2
AA2AR
A1
A2A
D2
TM6 6x41
L
V
A 3 2 25
5IU8, 3RFM, 6CM4, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 5N2S, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
0.05 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM7 7x41
T
S
A 2 1 24
5IU8, 3RFM, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 5N2S, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
0.38 0 0.50 12
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S 1 1 24
3ZPQ, 4AMI, 6H7L, 6IBL, 2Y02, 2Y00, 5F8U, 2YCX, 2YCZ, 2Y04, 3ZPR, 4GPO, 6H7N, 2VT4, 2Y03, 2Y01, 4AMJ, 4BVN, 5A8E, 2YCW, 6H7M, 6H7J, 2YCY, 6H7O
0.04 0.50 0.46
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V 1 1 25
3ZPQ, 4AMI, 6H7L, 6IBL, 2Y02, 2Y00, 5F8U, 2YCX, 2YCZ, 2Y04, 3ZPR, 4GPO, 6TKO, 6H7N, 2VT4, 2Y03, 2Y01, 4AMJ, 4BVN, 5A8E, 2YCW, 6H7M, 6H7J, 2YCY, 6H7O
0.23 0.33 0.61 -0.46 4
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM3 3x40
I
V 1 1 2
4BVN, 5A8E
0.24 0.61 -0.46 3
Intermediate
Active
Inactive
A (Rhodopsin)
Aminergic
Protein
Peptide
5-Hydroxytryptamine
Adrenoceptors
Neuropeptide Y
Dopamine
Chemokine
ADRB1
5HT1B
5HT2B
ADRB2
NPY1R
DRD3
CXCR4
5-HT1B
CXCR4
D3
β2
5-HT2B
Y1
β1
TM3 3x41
L
M
F
E
W 7 5 27
5TVN, 3NYA, 5TUD, 3D4S, 6DS0, 4IAQ, 3NY8, 6DRY, 4NC3, 3OE6, 5ZBH, 3OE8, 3OE0, 5ZBQ, 3ODU, 4IB4, 7C61, 3OE9, 5A8E, 4RWS, 3NY9, 3PBL, 6DRX, 6G79, 4IAR, 5V54, 6DRZ
0.03 0.49 -2.09 3
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM5 5x58
Y
A 1 1 18
2Y04, 3ZPQ, 4GPO, 4AMI, 2VT4, 2Y03, 2Y02, 2Y00, 2Y01, 4AMJ, 4BVN, 5A8E, 5F8U, 2YCW, 2YCX, 2YCZ, 2YCY, 3ZPR
0.03 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L 1 1 18
2Y04, 3ZPQ, 4GPO, 4AMI, 2VT4, 2Y03, 2Y02, 2Y00, 2Y01, 4AMJ, 4BVN, 5A8E, 5F8U, 2YCW, 2YCX, 2YCZ, 2YCY, 3ZPR
0.11 0.11 0.21 -1.25
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K 1 1 1
4BVN
0.04 0.11 0.26 2.80 16
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A 1 1 25
3ZPQ, 4AMI, 6H7L, 6IBL, 2Y02, 2Y00, 5F8U, 2YCX, 2YCZ, 2Y04, 3ZPR, 4GPO, 6TKO, 6H7N, 2VT4, 2Y03, 2Y01, 4AMJ, 4BVN, 5A8E, 2YCW, 6H7M, 6H7J, 2YCY, 6H7O
0.1 0.11 0 0.50
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48
F
M 1 1 25
3ZPQ, 4AMI, 6H7L, 6IBL, 2Y02, 2Y00, 5F8U, 2YCX, 2YCZ, 2Y04, 3ZPR, 4GPO, 6TKO, 6H7N, 2VT4, 2Y03, 2Y01, 4AMJ, 4BVN, 5A8E, 2YCW, 6H7M, 6H7J, 2YCY, 6H7O
0.05 0.24 -0.67
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L 1 1 2
4BVN, 5A8E
0.03 0.21 -1.25 Pos Match (But Not Mutant AA) Pos & Mutant AA Match 4
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C 1 1 2
3PDS, 4QKX
0.68 -0.02 16
Inactive
A (Rhodopsin)
Aminergic
Peptide
Apelin
Dopamine
DRD2
APJ
apelin
D2
TM3 3x40
V
I
A 2 2 2
5VBL, 6CM4
0.06 0 0.50 3
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K 1 1 1
5VBL
0.26 2.80 Pos Match (But Not Mutant AA) 34
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y 1 1 5
7F1T, 6AKY, 6AKX, 4MBS, 5UIW
0.07 0.53 -0.71 2
Active
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N 1 1 8
7F1T, 7F1Q, 6AKY, 6AKX, 7F1S, 4MBS, 7F1R, 5UIW
0.03 0.65 0.85 16
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D 1 1 5
7F1T, 6AKY, 6AKX, 4MBS, 5UIW
0.69 0.43 2 1 6
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E 1 1 5
7F1T, 6AKY, 6AKX, 4MBS, 5UIW
0.13 0.40 0.11 5 1 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A 1 1 1
5LWE
0.03 0 0.50 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A 1 1 1
5LWE
0.06 0 0.50 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A 1 1 1
5LWE
0.12 0 0.50 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C 1 1 1
5LWE
0.02 0.68 -0.02
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A 1 1 1
5LWE
0.07 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36
V
A 1 1 1
5LWE
0.02 0 0.50 2 1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A 1 1 1
5LWE
0.15 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A 1 1 1
5LWE
0.08 0 0.50 8
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A 1 1 4
5XR8, 5TGZ, 5U09, 5XRA
0.01 0 0.50 1
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37
E
K 1 1 3
5TGZ, 5XR8, 5XRA
0.11 0.26 2.80 2
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E 1 1 3
5TGZ, 5XR8, 5XRA
0.03 0.40 0.11 1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C 1 1 1
4RWS
0.68 -0.02 30
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36
T
P 1 1 3
3OE9, 3OE0, 4RWS
0.0 3.16 0.14 2 1 5
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y 1 1 2
5XPR, 5X93
0.09 0.53 -0.71
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A 1 1 1
5X93
0.08 0 0.50 5
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A 1 1 2
5XPR, 5X93
0.07 0 0.50 9
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A 1 1 2
5XPR, 5X93
0.1 0 0.50 5
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48
I
A 1 1 2
5XPR, 5X93
0.12 0 0.50
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A 1 1 4
5KW2, 5TZY, 4PHU, 5TZR
0.06 0 0.50 4 1 1
Intermediate
A (Rhodopsin)
Lipid
Peptide
Free fatty acid
Proteinase-activated
PAR2
FFAR1
FFA1
PAR2
TM3 3x34
F
G
A 2 2 6
5KW2, 5NDD, 4PHU, 5NDZ, 5NJ6, 5TZR
0.08 0 0.50 1
Active
Intermediate
A (Rhodopsin)
Lipid
Peptide
Neurotensin
Free fatty acid
NTR1
FFAR1
FFA1
NTS1
TM3 3x49
E
G
A 2 2 6
5KW2, 5TZY, 4PHU, 5TZR, 4GRV, 4XES
0.01 0 0.50 Pos & Mutant AA Match 2
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM5 5x58
Y
F 1 1 4
5KW2, 5TZY, 4PHU, 5TZR
0.01 0.54 -1.71
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37
D
C 1 1 1
4Z36
0.68 -0.02 2
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C 1 1 1
4Z36
0.01 0.68 -0.02 7
Active
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L 1 1 12
4BWB, 4BUO, 3ZEV, 4XEE, 4GRV, 7L0P, 7L0S, 7L0R, 4BV0, 5T04, 4XES, 7L0Q
0.36 0.21 -1.25
Active
Inactive
A (Rhodopsin)
Lipid
Peptide
Neurotensin
Leukotriene
NTR1
Q9WTK1
NTS1
BLT1
ECL2
G
S
A 2 2 5
5T04, 4XEE, 4GRV, 4XES, 5X33
0 0.50
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A 1 1 4
3ZEV, 4BWB, 4BV0, 4BUO
0.02 0 0.50
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A 1 1 4
4XEE, 5T04, 4GRV, 4XES
0.19 0 0.50
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term
D
N
C 2 1 20
5DYS, 4A4M, 4BEY, 5W0P, 6FK9, 6FK7, 2J4Y, 2X72, 6FKB, 6FKA, 3C9M, 6FKD, 4ZWJ, 5EN0, 5DGY, 4BEZ, 6CMO, 6FK6, 6FKC, 6FK8
0.68 -0.02
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I 1 1 2
5DYS, 5EN0
0.04 0.29 0.41 -1.12 31
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q 2 1 5
5W0P, 6CMO, 5DGY, 2X72, 4ZWJ
0.02 0.39 0.77 15
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y 2 1 5
4A4M, 5W0P, 6CMO, 5DGY, 4ZWJ
0.01 0.53 -0.71 1 1
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2RY1
P2Y12
P2Y1
P2Y12
TM7 7x49
D
N 2 1 5
4PXZ, 4XNV, 4NTJ, 4XNW, 4PY0
0.72 0.65 0.85
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.11 0 0.50 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.05 0 0.50 3 1 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L 1 1 3
5NDD, 5NJ6, 5NDZ
0.73 0.21 -1.25
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.01 0 0.50 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E 1 1 3
5NDD, 5NJ6, 5NDZ
0.01 0.40 0.11 5
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.12 0 0.50 1 3
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.14 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.13 0 0.50
Other
Intermediate
A (Rhodopsin)
Lipid
Platelet-activating factor
PTAFR
PAF
TM6 6x34
A
D 1 1 2
5ZKQ, 5ZKP
0.69 0.43
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G 1 1 1
5X33
0.27 1.00 1.15 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G 1 1 1
5X33
0.67 1.00 1.15 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A 1 1 1
5X33
0.08 0 0.50 1 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A 1 1 2
4Z9G, 4K5Y
0 0.50 5
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A 1 1 2
4K5Y, 4Z9G
0.07 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48
S
A 1 1 2
4K5Y, 4Z9G
0.2 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A 1 1 2
4K5Y, 4Z9G
0 0.50
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLP1R
CRFR1
CRF1
GLP-1
ECL2 45x52
T
F
A 2 2 3
4K5Y, 5NX2, 4Z9G
0 0.50 14
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLP1R
GLR
CRFR1
CRF1
glucagon
GLP-1
TM6 6x30
K
Y
A 3 2 5
5EE7, 4Z9G, 5VEX, 5VEW, 4K5Y
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A 1 1 2
4K5Y, 4Z9G
0 0.50 2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A 1 1 2
4K5Y, 4Z9G
0 0.50 11
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A 1 1 2
4K5Y, 4Z9G
0 0.50 Pos & Mutant AA Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x56
S
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM2 2x59
I
V
F 2 1 3
5VEX, 5EE7, 5VEW
0.54 -1.71
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
ECL1
T
G
E 2 1 2
5EE7, 5NX2
0.40 0.11
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
Q
G
A 1 1 1
5NX2
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
D
R 1 1 1
5NX2
0.21 1.81
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM3 3x24
S
G
A 2 1 3
5VEX, 5EE7, 5VEW
0.07 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F 1 1 1
5NX2
0.4 0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C 1 1 2
5VEX, 5VEW
0.68 -0.02 8
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2
L
F 1 1 1
5NX2
0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A 1 1 2
5VEX, 5VEW
0.07 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C 1 1 2
5VEX, 5VEW
0.68 -0.02 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I 1 1 2
5VEX, 5VEW
0.07 0.41 -1.12
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F 1 1 2
5VEX, 5VEW
0.07 0.54 -1.71 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A 1 1 1
5NX2
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V 1 1 1
5NX2
0.61 -0.46 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A 1 1 1
5NX2
0.07 0 0.50 2 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A 1 1 1
5EE7
0.33 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A 1 1 2
5EE7, 5YQZ
0 0.50 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48
A
L 1 1 1
5EE7
0.2 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x56
S
A 1 1 1
5EE7
0.27 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A 1 1 1
5EE7
0.27 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F 1 1 1
5EE7
0.13 0.54 -1.71 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A 1 1 1
5EE7
0.07 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A 1 1 5
6FFH, 5CGC, 6FFI, 5CGD, 4OO9
0.05 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y 1 1 5
6FFH, 5CGC, 6FFI, 5CGD, 4OO9
0.05 0.53 -0.71
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A 1 1 5
6FFH, 5CGC, 6FFI, 5CGD, 4OO9
0.05 0 0.50 Pos & Mutant AA Match
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M 1 1 5
6FFH, 5CGC, 6FFI, 5CGD, 4OO9
0.24 -0.67
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A 1 1 5
6FFH, 5CGC, 6FFI, 5CGD, 4OO9
0.05 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A 1 1 5
6FFH, 5CGC, 6FFI, 5CGD, 4OO9
0 0.50 1
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F 1 1 2
5L7D, 5L7I
0.54 -1.71 1
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N 1 1 2
6BQH, 6BQG
0.66 0.65 0.85 Pos & AA Mutant Match 1
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A 1 1 1
5WF6
0.03 0 0.50 Pos & AA Mutant Match 1
STATE TARGETS MUTATIONS FREQUENCY DATA (WILD TYPE) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46 L
A
1 1 4
4UHR, 4UG2, 2YDO, 2YDV
0.9 0.21 -1.25
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50 D
N
1 1 1
5WF5
0.92 0.69 0.43 Pos & Wild Type AA Match 1
Active
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM2 2x52 A
L
2 1 28
5IU8, 3RFM, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 4UG2, 5OM4, 5NM4, 4UHR, 2YDV, 3UZC, 5MZJ, 2YDO, 5NLX, 3REY, 5N2S, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
0.06 0 0.50 1
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62 T
A
1 1 4
4UG2, 2YDO, 4UHR, 2YDV
0.1 0.66 0.25
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM3 3x36 T
A
2 1 24
5IU8, 3RFM, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 5N2S, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
0.05 0.66 0.25 42
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37 Q
A
1 1 4
4UG2, 2YDO, 4UHR, 2YDV
0.02 0.39 0.77 16
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55 R
A
1 1 23
5IU8, 3RFM, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
0.04 0.21 1.81 1 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43 K
A
1 1 23
5IU8, 3RFM, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
0.16 0.26 2.80
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM5 5x63 L
A
1 1 23
5IU8, 3RFM, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
0.14 0.21 -1.25
Active
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Peptide
Neurotensin
Adenosine
Dopamine
NTR1
AA1R
DRD2
AA2AR
A1
A2A
NTS1
D2
TM6 6x37 L
A
4 3 26
5IU8, 3RFM, 6CM4, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 5N2S, 3UZA, 4GRV, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
0.38 0.21 -1.25 2 1 4
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM6 6x41 V
A
1 1 23
5IU8, 3RFM, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
0.41 0.61 -0.46
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM7 7x41 S
A
1 1 23
5IU8, 3RFM, 3PWH, 5NM2, 5OLH, 5IUA, 5OLO, 5OLG, 5OLV, 5N2R, 5OM4, 5NM4, 3UZC, 5MZJ, 5NLX, 3REY, 3UZA, 5MZP, 5OLZ, 5IUB, 5OM1, 5IU7, 5IU4
0.16 0.50 0.46 12
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59 R
S
1 1 24
3ZPQ, 4AMI, 6H7L, 6IBL, 2Y02, 2Y00, 5F8U, 2YCX, 2YCZ, 2Y04, 3ZPR, 4GPO, 6H7N, 2VT4, 2Y03, 2Y01, 4AMJ, 4BVN, 5A8E, 2YCW, 6H7M, 6H7J, 2YCY, 6H7O
0.24 0.21 1.81
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53 M
V
1 1 25
3ZPQ, 4AMI, 6H7L, 6IBL, 2Y02, 2Y00, 5F8U, 2YCX, 2YCZ, 2Y04, 3ZPR, 4GPO, 6TKO, 6H7N, 2VT4, 2Y03, 2Y01, 4AMJ, 4BVN, 5A8E, 2YCW, 6H7M, 6H7J, 2YCY, 6H7O
0.07 0.33 0.24 -0.67 4
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
Dopamine
ADRB1
DRD2
β1
D2
TM3 3x40 I
V
A
2 2 3
6CM4, 4BVN, 5A8E
0.39 0.41 -1.12 3
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
ADRB2
β2
β1
TM3 3x41 E
W
2 1 5
5A8E, 3NYA, 3NY8, 3NY9, 3D4S
0.01 0.33 0.40 0.11 3
Intermediate
Inactive
A (Rhodopsin)
Lipid
Aminergic
Adrenoceptors
Free fatty acid
ADRB1
FFAR1
FFA1
β1
TM5 5x58 Y
A
F
2 2 22
5KW2, 3ZPQ, 4AMI, 2Y02, 2Y00, 5TZY, 4PHU, 5F8U, 2YCX, 5TZR, 2YCZ, 2Y04, 4GPO, 2VT4, 2Y03, 2Y01, 4AMJ, 4BVN, 5A8E, 2YCW, 2YCY, 3ZPR
0.73 0.53 -0.71
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27 A
L
1 1 18
2Y04, 3ZPQ, 4GPO, 4AMI, 2VT4, 2Y03, 2Y02, 2Y00, 2Y01, 4AMJ, 4BVN, 5A8E, 5F8U, 2YCW, 2YCX, 2YCZ, 2YCY, 3ZPR
0.08 0.11 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31 D
K
1 1 1
4BVN
0.1 0.22 0.69 0.43 16
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36 F
A
1 1 25
3ZPQ, 4AMI, 6H7L, 6IBL, 2Y02, 2Y00, 5F8U, 2YCX, 2YCZ, 2Y04, 3ZPR, 4GPO, 6TKO, 6H7N, 2VT4, 2Y03, 2Y01, 4AMJ, 4BVN, 5A8E, 2YCW, 6H7M, 6H7J, 2YCY, 6H7O
0.14 0.44 0.54 -1.71
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48 F
M
1 1 25
3ZPQ, 4AMI, 6H7L, 6IBL, 2Y02, 2Y00, 5F8U, 2YCX, 2YCZ, 2Y04, 3ZPR, 4GPO, 6TKO, 6H7N, 2VT4, 2Y03, 2Y01, 4AMJ, 4BVN, 5A8E, 2YCW, 6H7M, 6H7J, 2YCY, 6H7O
0.06 0.33 0.54 -1.71
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53 Y
L
1 1 2
4BVN, 5A8E
0.89 1.0 0.53 -0.71 Pos & Wild Type AA Match Pos & Wild Type AA Match 4
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63 H
C
1 1 2
3PDS, 4QKX
0.03 0.11 0.61 0.11 16
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM3 3x40 V
A
1 1 1
5VBL
0.24 0.61 -0.46 3
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48 W
K
1 1 1
5VBL
0.67 0.49 -2.09 Pos & Wild Type AA Match 34
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60 C
Y
1 1 5
7F1T, 6AKY, 6AKX, 4MBS, 5UIW
0.02 0.68 -0.02 2
Active
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61 G
N
1 1 8
7F1T, 7F1Q, 6AKY, 6AKX, 7F1S, 4MBS, 7F1R, 5UIW
0.02 1.00 1.15 16
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33 A
D
1 1 5
7F1T, 6AKY, 6AKX, 4MBS, 5UIW
0.28 0 0.50 2 1 6
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49 K
E
1 1 5
7F1T, 6AKY, 6AKX, 4MBS, 5UIW
0.13 0.26 2.80 5 1 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48 T
A
1 1 1
5LWE
0.05 0.66 0.25 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50 V
A
1 1 1
5LWE
0.02 0.61 -0.46 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38 M
A
1 1 1
5LWE
0.04 0.24 -0.67 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47 S
C
1 1 1
5LWE
0.55 0.50 0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41 T
A
1 1 1
5LWE
0.09 0.66 0.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36 V
A
1 1 1
5LWE
0.16 0.61 -0.46 2 1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29 N
A
1 1 1
5LWE
0.04 0.65 0.85
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39 T
A
1 1 1
5LWE
0.03 0.66 0.25 8
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46 T
A
1 1 4
5XR8, 5TGZ, 5U09, 5XRA
0.01 0.66 0.25 1
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37 E
K
1 1 3
5TGZ, 5XR8, 5XRA
0.03 0.40 0.11 2
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32 R
E
1 1 3
5TGZ, 5XR8, 5XRA
0.31 0.21 1.81 1 5
Active
Inactive
A (Rhodopsin)
Aminergic
Protein
5-Hydroxytryptamine
Chemokine
Dopamine
5HT1B
DRD3
CXCR4
D3
5-HT1B
CXCR4
TM3 3x41 L
W
3 3 12
3OE6, 3OE8, 3OE0, 7C61, 3OE9, 4IAQ, 4RWS, 5V54, 3PBL, 6G79, 4IAR, 3ODU
0.31 0.21 -1.25 3
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51 D
C
1 1 1
4RWS
0.03 0.69 0.43 30
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36 T
P
1 1 3
3OE9, 3OE0, 4RWS
0.25 0.66 0.25 2 1 5
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Adenosine
Dopamine
AA1R
DRD2
A1
D2
TM6 6x41 L
A
2 2 2
5N2S, 6CM4
0.19 0.21 -1.25
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55 R
Y
1 1 2
5XPR, 5X93
0.02 0.21 1.81
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56 D
A
1 1 1
5X93
0.01 0.69 0.43 5
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36 K
A
1 1 2
5XPR, 5X93
0.06 0.26 2.80 9
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54 S
A
1 1 2
5XPR, 5X93
0.05 0.50 0.46 5
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48 I
A
1 1 2
5XPR, 5X93
0.15 0.41 -1.12
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40 L
A
1 1 4
5KW2, 5TZY, 4PHU, 5TZR
0.03 0.21 -1.25 4 1 1
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x34 F
A
1 1 3
5KW2, 4PHU, 5TZR
0.11 0.54 -1.71 1
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x49 G
A
1 1 4
5KW2, 5TZY, 4PHU, 5TZR
0.01 1.00 1.15 Pos & Wild Type AA Match 2
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37 D
C
1 1 1
4Z36
0.01 0.69 0.43 2
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59 V
C
1 1 1
4Z36
0.12 0.61 -0.46 7
Inactive
A (Rhodopsin)
Peptide
Neuropeptide Y
NPY1R
Y1
TM3 3x41 F
W
1 1 2
5ZBH, 5ZBQ
0.28 0.54 -1.71 3
Active
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54 A
L
1 1 12
4BWB, 4BUO, 3ZEV, 4XEE, 4GRV, 7L0P, 7L0S, 7L0R, 4BV0, 5T04, 4XES, 7L0Q
0.04 0 0.50
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM3 3x49 E
A
1 1 2
4GRV, 4XES
0.21 0.40 0.11 Pos & Wild Type AA Match 2
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
ECL2 G
A
1 1 4
4XEE, 5T04, 4GRV, 4XES
1.00 1.15
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54 I
A
1 1 4
3ZEV, 4BWB, 4BV0, 4BUO
0.34 0.41 -1.12
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43 V
A
1 1 4
4XEE, 5T04, 4GRV, 4XES
0.11 0.61 -0.46
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term N
C
2 1 20
5DYS, 4A4M, 4BEY, 5W0P, 6FK9, 6FK7, 2J4Y, 2X72, 6FKB, 6FKA, 3C9M, 6FKD, 4ZWJ, 5EN0, 5DGY, 4BEZ, 6CMO, 6FK6, 6FKC, 6FK8
0.65 0.85
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60 T
I
1 1 2
5DYS, 5EN0
0.08 0.43 0.66 0.25 31
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28 E
Q
2 1 5
5W0P, 6CMO, 5DGY, 2X72, 4ZWJ
0.02 0.57 0.40 0.11 15
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40 M
Y
2 1 5
4A4M, 5W0P, 6CMO, 5DGY, 4ZWJ
0.05 0.71 0.24 -0.67 1 1
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
ECL3 D
C
1 1 16
5DYS, 4A4M, 4BEY, 6FK9, 6FK7, 2J4Y, 2X72, 6FKB, 6FKA, 3C9M, 6FKD, 5EN0, 4BEZ, 6FK6, 6FKC, 6FK8
0.69 0.43
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2RY1
P2Y12
P2Y1
P2Y12
TM7 7x49 D
N
2 1 5
4PXZ, 4XNV, 4NTJ, 4XNW, 4PY0
0.2 0.69 0.43
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46 G
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.54 1.00 1.15 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37 H
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.03 0.61 0.11 3 1 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x34 G
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.02 1.00 1.15 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43 M
L
1 1 3
5NDD, 5NJ6, 5NDZ
0.05 0.24 -0.67
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51 Y
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.66 0.53 -0.71 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53 V
E
1 1 3
5NDD, 5NJ6, 5NDZ
0.07 0.61 -0.46 5
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64 M
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.01 0.24 -0.67 1 3
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38 I
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.09 0.41 -1.12
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42 L
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.24 0.21 -1.25
Other
Intermediate
A (Rhodopsin)
Lipid
Platelet-activating factor
PTAFR
PAF
TM6 6x34 A
D
1 1 2
5ZKQ, 5ZKP
0.24 0 0.50
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67 H
G
1 1 1
5X33
0.07 0.61 0.11 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21 K
G
1 1 1
5X33
0.01 0.26 2.80 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67 V
A
1 1 1
5X33
0.02 0.61 -0.46 1 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
C-term S
A
1 1 1
5X33
0.50 0.46
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36 V
A
1 1 2
4Z9G, 4K5Y
0.07 0.61 -0.46 5
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60 L
A
1 1 2
4Z9G, 4K5Y
0.33 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1