Stabilising Mutation Analyser

Group by: Mutant Subsets: Only show mutations present in minimum 2 GPCRs
STATE TARGETS MUTATIONS FREQUENCY SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS
No. Receptor Families
No. Structures
PDBs Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y
1 1 4
5UIW, 4MBS, 6AKY, 6AKX
2
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
ECL1
G
L
Q
D
T
F
R
E
A
2 1 2
5NX2, 5EE7
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A
1 1 3
5NDD, 5NDZ, 5NJ6
1 3
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C
1 1 2
4QKX, 3PDS
10
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A
1 1 5
6FFH, 5CGC, 6FFI, 4OO9, 5CGD
Pos Match
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM2 2x56
S
C
A
2 1 3
5VEW, 5EE7, 5VEX
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G
1 1 1
5X33
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Dopamine
Adenosine
AA2AR
AA1R
DRD2
A2A
A1
D2
TM6 6x41
V
L
A
3 2 25
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 5OLZ, 6CM4, 5OM1, 5MZJ, 5N2S, 5OLH, 5OLV, 5MZP, 5NM2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L
1 1 3
5NDD, 5NDZ, 5NJ6
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D
1 1 4
5UIW, 4MBS, 6AKY, 6AKX
2 1 6
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q
2 1 5
4ZWJ, 2X72, 6CMO, 5W0P, 5DGY
10
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E
1 1 3
5TGZ, 5XR8, 5XRA
1 5
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A
1 1 3
5NDD, 5NDZ, 5NJ6
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A
1 1 23
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 5OLZ, 5OM1, 5MZJ, 5OLH, 5OLV, 5MZP, 5NM2
Inactive
Active
A (Rhodopsin)
Peptide
Aminergic
Adrenoceptors
Endothelin
EDNRB
ADRB1
β1
ETB
TM7 7x48
I
F
M
A
2 2 26
2YCW, 4AMI, 4BVN, 2Y03, 5F8U, 2YCX, 2YCZ, 6H7J, 6H7M, 5X93, 4GPO, 6H7L, 5A8E, 2Y02, 3ZPR, 6IBL, 6H7O, 5XPR, 2Y00, 2YCY, 2Y04, 6H7N, 2VT4, 3ZPQ, 2Y01, 4AMJ
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E
1 1 4
5UIW, 4MBS, 6AKY, 6AKX
3 1 2
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A
1 1 1
5X33
1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM3 3x36
T
A
2 1 24
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 5OLZ, 5OM1, 5MZJ, 5N2S, 5OLH, 5OLV, 5MZP, 5NM2
18
Inactive
Active
Intermediate
A (Rhodopsin)
Peptide
Sensory
Lipid
Opsins
Neurotensin
Leukotriene
OPSD
Q9WTK1
OPSD
NTR1
NTS1
Rhodopsin
BLT1
N-term
D
G
N
S
C
A
4 3 17
5DYS, 5X33, 3C9M, 5DGY, 4ZWJ, 2J4Y, 4GRV, 4BEY, 4BEZ, 4XES, 2X72, 4A4M, 5W0P, 5EN0, 5T04, 6CMO, 4XEE
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM2 2x52
A
L
2 1 28
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 2YDO, 5OLZ, 4UHR, 5OM1, 2YDV, 5MZJ, 5N2S, 5OLH, 4UG2, 5OLV, 5MZP, 5NM2
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A
1 1 1
5EE7
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E
1 1 3
5NDD, 5NDZ, 5NJ6
5
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM7 7x41
T
S
A
2 1 24
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 5OLZ, 5OM1, 5MZJ, 5N2S, 5OLH, 5OLV, 5MZP, 5NM2
6
Intermediate
A (Rhodopsin)
Peptide
Lipid
Neurotensin
Free fatty acid
NTR1
FFAR1
NTS1
FFA1
TM3 3x49
G
E
A
2 2 6
4GRV, 4XES, 4PHU, 5TZR, 5KW2, 5TZY
Pos Match 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A
1 1 2
5VEW, 5VEX
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C
A
1 1 3
5NX2, 5VEW, 5VEX
Intermediate
Active
Inactive
A (Rhodopsin)
Aminergic
Protein
Adrenoceptors
Chemokine
Dopamine
5-Hydroxytryptamine
ADRB2
DRD3
ADRB1
CXCR4
5HT1B
5HT2B
D3
CXCR4
5-HT2B
5-HT1B
β1
β2
TM3 3x41
M
E
L
W
6 4 24
3D4S, 4IB4, 6DRX, 3OE0, 3NY8, 3NYA, 3NY9, 6DRY, 6DRZ, 4RWS, 3OE9, 5A8E, 6DS0, 5TUD, 5TVN, 4IAR, 5V54, 3ODU, 4NC3, 3OE8, 4IAQ, 3PBL, 6G79, 3OE6
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C
1 1 2
5VEW, 5VEX
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A
1 1 1
5LWE
6
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM3 3x24
G
S
A
2 1 3
5VEW, 5EE7, 5VEX
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A
1 1 2
4Z9G, 4K5Y
Pos Match 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A
1 1 4
2YDV, 4UHR, 2YDO, 4UG2
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A
1 1 5
6FFH, 5CGC, 6FFI, 4OO9, 5CGD
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A
1 1 2
5XPR, 5X93
3
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A
1 1 1
5LWE
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A
1 1 1
5NX2
2 2
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G
1 1 1
5X33
1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L
1 1 18
3ZPR, 2YCW, 4AMI, 4BVN, 2Y00, 2Y03, 2YCY, 5F8U, 2YCX, 2Y04, 2YCZ, 4GPO, 3ZPQ, 2VT4, 5A8E, 2Y01, 2Y02, 4AMJ
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C
1 1 1
4RWS
14
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M
1 1 5
6FFH, 5CGC, 6FFI, 4OO9, 5CGD
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A
1 1 2
4Z9G, 4K5Y
1
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A
1 1 4
3ZEV, 4BV0, 4BWB, 4BUO
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F
1 1 2
5VEW, 5VEX
1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L
1 1 2
4BVN, 5A8E
Pos Match Pos Match 3
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A
1 1 4
2YDV, 4UHR, 2YDO, 4UG2
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A
1 1 5
6FFH, 5CGC, 6FFI, 4OO9, 5CGD
Inactive
Active
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
Cannabinoid
LPAR1
CNR1
CB1
LPA1
TM5 5x37
D
E
C
K
2 2 4
5TGZ, 4Z36, 5XR8, 5XRA
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F
1 1 1
5NX2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A
1 1 3
5NDD, 5NDZ, 5NJ6
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C
1 1 1
4Z36
4
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S
1 1 24
2YCW, 4AMI, 4BVN, 2Y03, 5F8U, 2YCX, 2YCZ, 6H7J, 6H7M, 4GPO, 6H7L, 5A8E, 2Y02, 3ZPR, 6IBL, 6H7O, 2Y00, 2YCY, 2Y04, 6H7N, 2VT4, 3ZPQ, 2Y01, 4AMJ
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A
1 1 1
5WF6
Pos Match 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V
1 1 1
5NX2
1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A
1 1 3
5NDD, 5NDZ, 5NJ6
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A
1 1 2
4Z9G, 4K5Y
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C
1 1 2
5VEW, 5VEX
1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM5 5x63
Y
L
A
2 1 24
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 5OLZ, 5OM1, 5MZJ, 5N2S, 5OLH, 5OLV, 5MZP, 5NM2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A
1 1 1
5LWE
1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N
1 1 1
5WF5
Pos Match 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A
1 1 2
4Z9G, 4K5Y
1
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F
1 1 2
5L7D, 5L7I
1
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A
1 1 24
2YCW, 4AMI, 4BVN, 2Y03, 5F8U, 2YCX, 2YCZ, 6H7J, 6H7M, 4GPO, 6H7L, 5A8E, 2Y02, 3ZPR, 6IBL, 6H7O, 2Y00, 2YCY, 2Y04, 6H7N, 2VT4, 3ZPQ, 2Y01, 4AMJ
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A
1 1 1
5X93
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K
1 1 1
5VBL
Pos Match 22
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A
1 1 1
5LWE
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V
1 1 24
2YCW, 4AMI, 4BVN, 2Y03, 5F8U, 2YCX, 2YCZ, 6H7J, 6H7M, 4GPO, 6H7L, 5A8E, 2Y02, 3ZPR, 6IBL, 6H7O, 2Y00, 2YCY, 2Y04, 6H7N, 2VT4, 3ZPQ, 2Y01, 4AMJ
2
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLP1R
GLR
CRF1
GLP-1
glucagon
TM6 6x30
Y
K
A
3 2 5
5VEX, 4Z9G, 5VEW, 5EE7, 4K5Y
Intermediate
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A
1 1 4
4XES, 5T04, 4GRV, 4XEE
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A
1 1 3
5NDD, 5NDZ, 5NJ6
1 1 1
Inactive
Intermediate
A (Rhodopsin)
Aminergic
Lipid
Adrenoceptors
Free fatty acid
ADRB1
FFAR1
FFA1
β1
TM5 5x58
Y
F
A
2 2 22
2YCW, 4AMI, 4BVN, 2Y03, 5F8U, 2YCX, 2YCZ, 4GPO, 5A8E, 3ZPR, 5KW2, 2Y02, 4PHU, 2Y00, 5TZR, 2YCY, 2Y04, 3ZPQ, 2VT4, 2Y01, 4AMJ, 5TZY
Intermediate
A (Rhodopsin)
Peptide
Lipid
Free fatty acid
Proteinase-activated
PAR2
FFAR1
FFA1
PAR2
TM3 3x34
F
G
A
2 2 5
5NDD, 5NDZ, 5NJ6, 5TZR, 4PHU
1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A
1 1 2
4Z9G, 4K5Y
Inactive
Active
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N
1 1 2
6BQH, 6BQG
Pos Match 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CXCR4
CXCR4
CCR9
TM6 6x36
V
T
P
A
2 1 4
3OE0, 5LWE, 3OE9, 4RWS
2 1 5
Inactive
Intermediate
A (Rhodopsin)
Peptide
Aminergic
Nucleotide
Neurotensin
Dopamine
Adenosine
AA2AR
AA1R
DRD2
NTR1
NTS1
A2A
A1
D2
TM6 6x37
L
A
4 3 26
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 5OLZ, 6CM4, 5OM1, 4GRV, 5MZJ, 5N2S, 5OLH, 5OLV, 5MZP, 5NM2
1 1 4
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A
1 1 1
5EE7
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A
1 1 2
4Z9G, 4K5Y
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I
1 1 2
5DYS, 5EN0
17
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A
1 1 4
5TGZ, 5U09, 5XR8, 5XRA
1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A
1 1 23
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 5OLZ, 5OM1, 5MZJ, 5OLH, 5OLV, 5MZP, 5NM2
1 2
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y
2 1 5
5W0P, 4ZWJ, 4A4M, 6CMO, 5DGY
1 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A
1 1 1
5LWE
4
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A
1 1 2
5XPR, 5X93
2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A
1 1 2
4Z9G, 4K5Y
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A
1 1 5
6FFH, 5CGC, 6FFI, 4OO9, 5CGD
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K
1 1 1
4BVN
8
Inactive
A (Rhodopsin)
Peptide
Aminergic
Adrenoceptors
Dopamine
Apelin
DRD2
ADRB1
APJ
apelin
D2
β1
TM3 3x40
I
V
V
A
3 3 4
4BVN, 5A8E, 6CM4, 5VBL
2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A
1 1 1
5NX2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C
1 1 1
5LWE
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I
1 1 2
5VEW, 5VEX
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y
1 1 5
6FFH, 5CGC, 6FFI, 4OO9, 5CGD
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F
1 1 1
5EE7
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM2 2x59
I
V
F
2 1 3
5VEW, 5EE7, 5VEX
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A
1 1 2
5EE7, 5YQZ
2
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A
1 1 4
2YDV, 4UHR, 2YDO, 4UG2
9
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A
1 1 4
5TZY, 5TZR, 5KW2, 4PHU
2 1 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A
1 1 1
5EE7
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLP1R
CRF1
GLP-1
ECL2 45x52
F
T
A
2 2 3
4Z9G, 5NX2, 4K5Y
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2RY1
P2Y12
P2Y1
P2Y12
TM7 7x49
D
N
2 1 5
4PY0, 4XNV, 4PXZ, 4XNW, 4NTJ
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y
1 1 2
5XPR, 5X93
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A
1 1 1
5LWE
Inactive
Intermediate
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L
1 1 8
4XES, 4BWB, 3ZEV, 4BV0, 5T04, 4BUO, 4XEE, 4GRV
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N
1 1 4
5UIW, 4MBS, 6AKY, 6AKX
6
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A
1 1 3
5NDD, 5NDZ, 5NJ6
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A
1 1 2
4Z9G, 4K5Y
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLR
CRF1
glucagon
TM2 2x48
A
S
A
L
2 2 3
4Z9G, 5EE7, 4K5Y
STATE TARGETS MUTATIONS FREQUENCY DATA (MUTANT) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L 1 1 18
3ZPR, 2YCW, 4AMI, 4BVN, 2Y00, 2Y03, 2YCY, 5F8U, 2YCX, 2Y04, 2YCZ, 4GPO, 3ZPQ, 2VT4, 5A8E, 2Y01, 2Y02, 4AMJ
0.11 0.11 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A 1 1 1
5EE7
0.33 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A 1 1 3
5NDD, 5NDZ, 5NJ6
0.14 0 0.50
Inactive
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term
D
N
C 2 1 12
5DYS, 3C9M, 5DGY, 4ZWJ, 2J4Y, 4BEY, 4BEZ, 2X72, 4A4M, 5W0P, 5EN0, 6CMO
0.68 -0.02
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q 2 1 5
4ZWJ, 2X72, 6CMO, 5W0P, 5DGY
0.01 0.39 0.77 10
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A 1 1 4
2YDV, 4UHR, 2YDO, 4UG2
0.13 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A 1 1 5
6FFH, 5CGC, 6FFI, 4OO9, 5CGD
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A 1 1 1
5LWE
0.13 0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A 1 1 4
2YDV, 4UHR, 2YDO, 4UG2
0.03 0 0.50 9
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48
I
A 1 1 2
5XPR, 5X93
0.13 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A 1 1 2
5EE7, 5YQZ
0 0.50 2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A 1 1 23
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 5OLZ, 5OM1, 5MZJ, 5OLH, 5OLV, 5MZP, 5NM2
0.13 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F 1 1 1
5NX2
0.4 0.54 -1.71
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C 1 1 2
4QKX, 3PDS
0.0 0.68 -0.02 10
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A 1 1 1
5NX2
0 0.50
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C 1 1 1
4Z36
0.01 0.68 -0.02 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A 1 1 1
5LWE
0.03 0 0.50 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D 1 1 4
5UIW, 4MBS, 6AKY, 6AKX
0.69 0.43 2 1 6
Intermediate
Active
Inactive
A (Rhodopsin)
Aminergic
Protein
Adrenoceptors
Chemokine
Dopamine
5-Hydroxytryptamine
ADRB2
DRD3
ADRB1
CXCR4
5HT1B
5HT2B
D3
CXCR4
5-HT2B
5-HT1B
β1
β2
TM3 3x41
M
E
L
W 6 4 24
3D4S, 4IB4, 6DRX, 3OE0, 3NY8, 3NYA, 3NY9, 6DRY, 6DRZ, 4RWS, 3OE9, 5A8E, 6DS0, 5TUD, 5TVN, 4IAR, 5V54, 3ODU, 4NC3, 3OE8, 4IAQ, 3PBL, 6G79, 3OE6
0.03 0.49 -2.09 1
Inactive
Active
Intermediate
A (Rhodopsin)
Peptide
Lipid
Neurotensin
Leukotriene
Q9WTK1
NTR1
NTS1
BLT1
C-term
G
S
A 2 2 5
4XES, 5X33, 5T04, 4GRV, 4XEE
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A 1 1 2
4Z9G, 4K5Y
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A 1 1 3
5NDD, 5NDZ, 5NJ6
0.13 0 0.50 1 3
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A 1 1 2
4Z9G, 4K5Y
0 0.50 Pos & Mutant AA Match 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A 1 1 23
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 5OLZ, 5OM1, 5MZJ, 5OLH, 5OLV, 5MZP, 5NM2
0.08 0 0.50 1 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N 1 1 4
5UIW, 4MBS, 6AKY, 6AKX
0.03 0.65 0.85 6
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM5 5x63
Y
L
A 2 1 24
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 5OLZ, 5OM1, 5MZJ, 5N2S, 5OLH, 5OLV, 5MZP, 5NM2
0.06 0 0.50
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I 1 1 2
5DYS, 5EN0
0.04 0.29 0.41 -1.12 17
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x56
S
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I 1 1 2
5VEW, 5VEX
0.07 0.41 -1.12
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y 1 1 2
5XPR, 5X93
0.09 0.53 -0.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM3 3x24
G
S
A 2 1 3
5VEW, 5EE7, 5VEX
0.07 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM3 3x40
I
V 1 1 2
4BVN, 5A8E
0.24 0.61 -0.46 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2
L
F 1 1 1
5NX2
0.54 -1.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A 1 1 1
5LWE
0.06 0 0.50 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A 1 1 1
5WF6
0.03 0 0.50 Pos & AA Mutant Match 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G 1 1 1
5X33
0.24 1.00 1.15
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A 1 1 5
6FFH, 5CGC, 6FFI, 4OO9, 5CGD
0 0.50 Pos & Mutant AA Match
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K 1 1 1
4BVN
0.04 0.11 0.26 2.80 8
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x56
S
A 1 1 1
5EE7
0.27 0 0.50
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F 1 1 2
5L7D, 5L7I
0.54 -1.71 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A 1 1 5
6FFH, 5CGC, 6FFI, 4OO9, 5CGD
0.05 0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A 1 1 1
5X93
0.08 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM5 5x58
Y
A 1 1 18
3ZPR, 2YCW, 4AMI, 4BVN, 2Y00, 2Y03, 2YCY, 5F8U, 2YCX, 2Y04, 2YCZ, 4GPO, 3ZPQ, 2VT4, 5A8E, 2Y01, 2Y02, 4AMJ
0.03 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L 1 1 2
4BVN, 5A8E
0.03 0.21 -1.25 Pos Match (But Not Mutant AA) Pos & Mutant AA Match 3
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A 1 1 1
5NX2
0 0.50
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A 1 1 24
2YCW, 4AMI, 4BVN, 2Y03, 5F8U, 2YCX, 2YCZ, 6H7J, 6H7M, 4GPO, 6H7L, 5A8E, 2Y02, 3ZPR, 6IBL, 6H7O, 2Y00, 2YCY, 2Y04, 6H7N, 2VT4, 3ZPQ, 2Y01, 4AMJ
0.1 0.11 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V 1 1 1
5NX2
0.61 -0.46 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L 1 1 3
5NDD, 5NDZ, 5NJ6
0.73 0.21 -1.25
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM3 3x36
T
A 2 1 24
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 5OLZ, 5OM1, 5MZJ, 5N2S, 5OLH, 5OLV, 5MZP, 5NM2
0.02 0 0.50 18
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48
F
M 1 1 24
2YCW, 4AMI, 4BVN, 2Y03, 5F8U, 2YCX, 2YCZ, 6H7J, 6H7M, 4GPO, 6H7L, 5A8E, 2Y02, 3ZPR, 6IBL, 6H7O, 2Y00, 2YCY, 2Y04, 6H7N, 2VT4, 3ZPQ, 2Y01, 4AMJ
0.05 0.24 -0.67
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A 1 1 4
5TGZ, 5U09, 5XR8, 5XRA
0.01 0 0.50 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C 1 1 1
4RWS
0.68 -0.02 14
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A 1 1 2
4Z9G, 4K5Y
0 0.50 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A 1 1 1
5LWE
0.12 0 0.50 1
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Dopamine
Adenosine
AA2AR
AA1R
DRD2
A2A
A1
D2
TM6 6x41
V
L
A 3 2 25
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 5OLZ, 6CM4, 5OM1, 5MZJ, 5N2S, 5OLH, 5OLV, 5MZP, 5NM2
0.05 0 0.50
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A 1 1 1
5X33
0.08 0 0.50 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
G
Q
A 1 1 1
5NX2
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Lipid
Free fatty acid
Proteinase-activated
PAR2
FFAR1
FFA1
PAR2
TM3 3x34
F
G
A 2 2 5
5NDD, 5NDZ, 5NJ6, 5TZR, 4PHU
0.07 0 0.50 1
Inactive
Intermediate
A (Rhodopsin)
Peptide
Aminergic
Nucleotide
Neurotensin
Dopamine
Adenosine
AA2AR
AA1R
DRD2
NTR1
NTS1
A2A
A1
D2
TM6 6x37
L
A 4 3 26
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 5OLZ, 6CM4, 5OM1, 4GRV, 5MZJ, 5N2S, 5OLH, 5OLV, 5MZP, 5NM2
0.04 0 0.50 1 1 4
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C 1 1 1
5LWE
0.02 0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A 1 1 2
4Z9G, 4K5Y
0.07 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M 1 1 5
6FFH, 5CGC, 6FFI, 4OO9, 5CGD
0.24 -0.67
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2RY1
P2Y12
P2Y1
P2Y12
TM7 7x49
D
N 2 1 5
4PY0, 4XNV, 4PXZ, 4XNW, 4NTJ
0.72 0.65 0.85
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A 1 1 2
5XPR, 5X93
0.1 0 0.50 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A 1 1 2
5VEW, 5VEX
0.07 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E 1 1 3
5NDD, 5NDZ, 5NJ6
0.01 0.40 0.11 5
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A 1 1 3
5NDD, 5NDZ, 5NJ6
0.05 0 0.50 1 1 1
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S 1 1 24
2YCW, 4AMI, 4BVN, 2Y03, 5F8U, 2YCX, 2YCZ, 6H7J, 6H7M, 4GPO, 6H7L, 5A8E, 2Y02, 3ZPR, 6IBL, 6H7O, 2Y00, 2YCY, 2Y04, 6H7N, 2VT4, 3ZPQ, 2Y01, 4AMJ
0.04 0.50 0.46
Inactive
Intermediate
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L 1 1 8
4XES, 4BWB, 3ZEV, 4BV0, 5T04, 4BUO, 4XEE, 4GRV
0.37 0.21 -1.25
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM5 5x58
Y
F 1 1 4
5TZY, 5TZR, 5KW2, 4PHU
0.01 0.54 -1.71
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37
E
K 1 1 3
5TGZ, 5XR8, 5XRA
0.11 0.26 2.80 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A 1 1 1
5EE7
0.07 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y 1 1 4
5UIW, 4MBS, 6AKY, 6AKX
0.07 0.53 -0.71 2
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E 1 1 3
5TGZ, 5XR8, 5XRA
0.04 0.40 0.11 1 5
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F 1 1 2
5VEW, 5VEX
0.07 0.54 -1.71 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E 1 1 4
5UIW, 4MBS, 6AKY, 6AKX
0.12 0.40 0.11 3 1 2
Intermediate
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A 1 1 4
4XES, 5T04, 4GRV, 4XEE
0.19 0 0.50
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37
D
C 1 1 1
4Z36
0.68 -0.02 1
Inactive
A (Rhodopsin)
Peptide
Aminergic
Dopamine
Apelin
DRD2
APJ
apelin
D2
TM3 3x40
I
V
A 2 2 2
6CM4, 5VBL
0.06 0 0.50 2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A 1 1 3
5NDD, 5NDZ, 5NJ6
0.13 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A 1 1 3
5NDD, 5NDZ, 5NJ6
0.0 0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N 1 1 1
5WF5
0.03 0.65 0.85 Pos & AA Mutant Match 1
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A 1 1 4
3ZEV, 4BV0, 4BWB, 4BUO
0.02 0 0.50
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A 1 1 4
5TZY, 5TZR, 5KW2, 4PHU
0.06 0 0.50 2 1 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
D
R 1 1 1
5NX2
0.21 1.81
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM2 2x52
A
L 2 1 28
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 2YDO, 5OLZ, 4UHR, 5OM1, 2YDV, 5MZJ, 5N2S, 5OLH, 4UG2, 5OLV, 5MZP, 5NM2
0.63 0.21 -1.25 1
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V 1 1 24
2YCW, 4AMI, 4BVN, 2Y03, 5F8U, 2YCX, 2YCZ, 6H7J, 6H7M, 4GPO, 6H7L, 5A8E, 2Y02, 3ZPR, 6IBL, 6H7O, 2Y00, 2YCY, 2Y04, 6H7N, 2VT4, 3ZPQ, 2Y01, 4AMJ
0.23 0.33 0.61 -0.46 2
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLP1R
GLR
CRF1
GLP-1
glucagon
TM6 6x30
Y
K
A 3 2 5
5VEX, 4Z9G, 5VEW, 5EE7, 4K5Y
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48
S
A 1 1 2
4Z9G, 4K5Y
0.2 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A 1 1 1
5EE7
0.27 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C 1 1 2
5VEW, 5VEX
0.68 -0.02 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A 1 1 3
5NDD, 5NDZ, 5NJ6
0.11 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A 1 1 1
5LWE
0.07 0 0.50
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
ECL1
G
T
E 2 1 2
5NX2, 5EE7
0.40 0.11
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G 1 1 1
5X33
0.67 1.00 1.15 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A 1 1 2
5XPR, 5X93
0.07 0 0.50 2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A 1 1 2
4Z9G, 4K5Y
0 0.50 1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y 2 1 5
5W0P, 4ZWJ, 4A4M, 6CMO, 5DGY
0.01 0.53 -0.71 1 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36
T
P 1 1 3
3OE0, 3OE9, 4RWS
0.0 3.16 0.14 2 1 5
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM7 7x41
T
S
A 2 1 24
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 5OLZ, 5OM1, 5MZJ, 5N2S, 5OLH, 5OLV, 5MZP, 5NM2
0.38 0 0.50 6
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A 1 1 1
5NX2
0.07 0 0.50 2 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLP1R
CRF1
GLP-1
ECL2 45x52
F
T
A 2 2 3
4Z9G, 5NX2, 4K5Y
0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A 1 1 4
2YDV, 4UHR, 2YDO, 4UG2
0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y 1 1 5
6FFH, 5CGC, 6FFI, 4OO9, 5CGD
0.05 0.53 -0.71
Inactive
Active
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N 1 1 2
6BQH, 6BQG
0.67 0.65 0.85 Pos & AA Mutant Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F 1 1 1
5EE7
0.13 0.54 -1.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A 1 1 1
5LWE
0.08 0 0.50 6
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A 1 1 5
6FFH, 5CGC, 6FFI, 4OO9, 5CGD
0.05 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48
A
L 1 1 1
5EE7
0.2 0.21 -1.25
Intermediate
A (Rhodopsin)
Peptide
Lipid
Neurotensin
Free fatty acid
NTR1
FFAR1
NTS1
FFA1
TM3 3x49
G
E
A 2 2 6
4GRV, 4XES, 4PHU, 5TZR, 5KW2, 5TZY
0.01 0 0.50 Pos & Mutant AA Match 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM2 2x59
I
V
F 2 1 3
5VEW, 5EE7, 5VEX
0.54 -1.71
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K 1 1 1
5VBL
0.26 2.80 Pos Match (But Not Mutant AA) 22
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36
V
A 1 1 1
5LWE
0.02 0 0.50 2 1 5
STATE TARGETS MUTATIONS FREQUENCY DATA (WILD TYPE) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61 G
N
1 1 4
5UIW, 4MBS, 6AKY, 6AKX
0.02 1.00 1.15 6
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50 V
A
1 1 1
5LWE
0.02 0.61 -0.46 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35 E
A
1 1 5
6FFH, 5CGC, 6FFI, 4OO9, 5CGD
0.09 0.40 0.11
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM7 7x41 T
A
1 1 1
5N2S
0.07 0.66 0.25 6
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x30 Y
A
1 1 2
4Z9G, 4K5Y
0.73 0.53 -0.71
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53 S
A
1 1 5
6FFH, 5CGC, 6FFI, 4OO9, 5CGD
0.14 0.50 0.46
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x49 G
A
1 1 4
5TZY, 5TZR, 5KW2, 4PHU
0.01 1.00 1.15 Pos & Wild Type AA Match 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48 T
A
1 1 1
5LWE
0.05 0.66 0.25 4
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM5 5x63 Y
A
1 1 1
5N2S
0.03 0.53 -0.71
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38 S
A
1 1 2
4Z9G, 4K5Y
0.13 0.50 0.46 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37 Q
A
1 1 4
2YDV, 4UHR, 2YDO, 4UG2
0.02 0.39 0.77 9
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31 D
K
1 1 1
4BVN
0.1 0.22 0.69 0.43 8
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60 C
Y
1 1 4
5UIW, 4MBS, 6AKY, 6AKX
0.02 0.68 -0.02 2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53 Y
A
1 1 2
4Z9G, 4K5Y
0.93 0.53 -0.71 Pos & Wild Type AA Match 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43 K
A
1 1 2
4Z9G, 4K5Y
0.13 0.26 2.80
Inactive
Intermediate
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54 A
L
1 1 8
4XES, 4BWB, 3ZEV, 4BV0, 5T04, 4BUO, 4XEE, 4GRV
0.04 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL2 45x52 T
A
1 1 1
5NX2
0.2 0.66 0.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44 W
A
1 1 2
4Z9G, 4K5Y
0.13 0.49 -2.09
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x59 I
F
1 1 2
5VEW, 5VEX
0.4 0.41 -1.12
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59 V
C
1 1 1
4Z36
0.12 0.61 -0.46 4
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21 K
G
1 1 1
5X33
0.01 0.26 2.80 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 T
E
1 1 1
5NX2
0.66 0.25
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2 L
F
1 1 1
5NX2
0.21 -1.25
Intermediate
Active
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2B
5-HT2B
TM3 3x41 M
W
1 1 8
6DRY, 6DS0, 4NC3, 5TVN, 6DRZ, 5TUD, 4IB4, 6DRX
0.04 0.24 -0.67 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51 Y
A
1 1 3
5NDD, 5NDZ, 5NJ6
0.66 0.53 -0.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48 S
A
1 1 2
5VEW, 5VEX
0.07 0.50 0.46
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67 H
G
1 1 1
5X33
0.08 0.61 0.11
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36 T
P
1 1 3
3OE0, 3OE9, 4RWS
0.25 0.66 0.25 2 1 5
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50 D
N
1 1 1
5WF5
0.92 0.69 0.43 Pos & Wild Type AA Match 1
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
ECL2 G
E
A
2 1 2
5NX2, 5EE7
1.00 1.15
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29 N
A
1 1 1
5LWE
0.04 0.65 0.85
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x34 G
A
1 1 3
5NDD, 5NDZ, 5NJ6
0.02 1.00 1.15 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31 C
F
1 1 2
5VEW, 5VEX
0.07 0.68 -0.02 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41 T
A
1 1 1
5LWE
0.09 0.66 0.25
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31 L
F
1 1 1
5NX2
0.2 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
ECL2 45x52 F
A
1 1 2
4Z9G, 4K5Y
0.13 0.54 -1.71
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM3 3x49 E
A
1 1 2
4XES, 4GRV
0.21 0.40 0.11 Pos & Wild Type AA Match 2
Inactive
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
ECL3 D
C
1 1 8
5DYS, 4BEZ, 4BEY, 2X72, 4A4M, 3C9M, 5EN0, 2J4Y
0.69 0.43
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36 F
A
1 1 24
2YCW, 4AMI, 4BVN, 2Y03, 5F8U, 2YCX, 2YCZ, 6H7J, 6H7M, 4GPO, 6H7L, 5A8E, 2Y02, 3ZPR, 6IBL, 6H7O, 2Y00, 2YCY, 2Y04, 6H7N, 2VT4, 3ZPQ, 2Y01, 4AMJ
0.14 0.44 0.54 -1.71
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37 D
C
1 1 1
4Z36
0.01 0.69 0.43 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54 S
A
1 1 2
5XPR, 5X93
0.05 0.50 0.46 3
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM3 3x40 V
A
1 1 1
5VBL
0.24 0.61 -0.46 2
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53 Y
L
1 1 2
4BVN, 5A8E
0.89 1.0 0.53 -0.71 Pos & Wild Type AA Match Pos & Wild Type AA Match 3
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40 V
F
1 1 2
5L7D, 5L7I
0.09 0.09 0.61 -0.46 1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60 T
I
1 1 2
5DYS, 5EN0
0.08 0.43 0.66 0.25 17
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Dopamine
Adenosine
AA1R
DRD2
A1
D2
TM6 6x41 L
A
2 2 2
6CM4, 5N2S
0.19 0.21 -1.25
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47 H
V
1 1 1
5NX2
0.73 0.61 0.11 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32 M
C
1 1 2
5VEW, 5VEX
0.13 0.24 -0.67
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53 V
E
1 1 3
5NDD, 5NDZ, 5NJ6
0.07 0.61 -0.46 5
Inactive
Intermediate
A (Rhodopsin)
Peptide
Aminergic
Nucleotide
Neurotensin
Dopamine
Adenosine
AA2AR
AA1R
DRD2
NTR1
NTS1
A2A
A1
D2
TM6 6x37 L
A
4 3 26
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 5OLZ, 6CM4, 5OM1, 4GRV, 5MZJ, 5N2S, 5OLH, 5OLV, 5MZP, 5NM2
0.38 0.21 -1.25 1 1 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49 K
E
1 1 4
5UIW, 4MBS, 6AKY, 6AKX
0.13 0.26 2.80 3 1 2
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
Dopamine
DRD2
ADRB1
D2
β1
TM3 3x40 I
V
A
2 2 3
4BVN, 5A8E, 6CM4
0.4 0.41 -1.12 2
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46 T
A
1 1 4
5TGZ, 5U09, 5XR8, 5XRA
0.01 0.66 0.25 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39 R
A
1 1 2
5EE7, 5YQZ
1.0 0.21 1.81 2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43 M
L
1 1 3
5NDD, 5NDZ, 5NJ6
0.05 0.24 -0.67
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM3 3x24 G
A
1 1 1
5EE7
0.4 1.00 1.15
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53 M
V
1 1 24
2YCW, 4AMI, 4BVN, 2Y03, 5F8U, 2YCX, 2YCZ, 6H7J, 6H7M, 4GPO, 6H7L, 5A8E, 2Y02, 3ZPR, 6IBL, 6H7O, 2Y00, 2YCY, 2Y04, 6H7N, 2VT4, 3ZPQ, 2Y01, 4AMJ
0.07 0.33 0.24 -0.67 2
Intermediate
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
ECL2 G
A
1 1 4
4XES, 5T04, 4GRV, 4XEE
1.00 1.15
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36 K
A
1 1 2
5XPR, 5X93
0.06 0.26 2.80 2
Inactive
Intermediate
A (Rhodopsin)
Aminergic
Lipid
Adrenoceptors
Free fatty acid
ADRB1
FFAR1
FFA1
β1
TM5 5x58 Y
F
A
2 2 22
2YCW, 4AMI, 4BVN, 2Y03, 5F8U, 2YCX, 2YCZ, 4GPO, 5A8E, 3ZPR, 5KW2, 2Y02, 4PHU, 2Y00, 5TZR, 2YCY, 2Y04, 3ZPQ, 2VT4, 2Y01, 4AMJ, 5TZY
0.72 0.53 -0.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39 T
A
1 1 1
5LWE
0.03 0.66 0.25 6
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42 P
A
1 1 1
5NX2
0.93 3.16 0.14
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
C-term S
A
1 1 1
5X33
0.50 0.46
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM5 5x63 L
A
1 1 23
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 5OLZ, 5OM1, 5MZJ, 5OLH, 5OLV, 5MZP, 5NM2
0.13 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x59 V
F
1 1 1
5EE7
0.4 0.61 -0.46
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27 A
L
1 1 18
3ZPR, 2YCW, 4AMI, 4BVN, 2Y00, 2Y03, 2YCY, 5F8U, 2YCX, 2Y04, 2YCZ, 4GPO, 3ZPQ, 2VT4, 5A8E, 2Y01, 2Y02, 4AMJ
0.08 0.11 0 0.50
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37 E
K
1 1 3
5TGZ, 5XR8, 5XRA
0.03 0.40 0.11 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39 S
A
1 1 1
5WF6
0.72 0.50 0.46 Pos & Wild Type AA Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48 G
A
1 1 1
5EE7
0.13 1.00 1.15
Inactive
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term N
C
2 1 12
5DYS, 3C9M, 5DGY, 4ZWJ, 2J4Y, 4BEY, 4BEZ, 2X72, 4A4M, 5W0P, 5EN0, 6CMO
0.65 0.85
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM6 6x30 K
A
2 1 3
5VEW, 5EE7, 5VEX
0.2 0.26 2.80
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48 F
M
1 1 24
2YCW, 4AMI, 4BVN, 2Y03, 5F8U, 2YCX, 2YCZ, 6H7J, 6H7M, 4GPO, 6H7L, 5A8E, 2Y02, 3ZPR, 6IBL, 6H7O, 2Y00, 2YCY, 2Y04, 6H7N, 2VT4, 3ZPQ, 2Y01, 4AMJ
0.06 0.33 0.54 -1.71
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42 L
A
1 1 3
5NDD, 5NDZ, 5NJ6
0.24 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x24 S
A
1 1 2
5VEW, 5VEX
0.27 0.50 0.46
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28 E
Q
2 1 5
4ZWJ, 2X72, 6CMO, 5W0P, 5DGY
0.02 0.57 0.40 0.11 10
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46 G
A
1 1 3
5NDD, 5NDZ, 5NJ6
0.54 1.00 1.15
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37 H
A
1 1 3
5NDD, 5NDZ, 5NJ6
0.03 0.61 0.11 1 1 1
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x34 F
A
1 1 2
5TZR, 4PHU
0.11 0.54 -1.71 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
ADRB1
β1
β2
TM3 3x41 E
W
2 1 5
3D4S, 5A8E, 3NY8, 3NYA, 3NY9
0.01 0.33 0.40 0.11 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62 T
A
1 1 4
2YDV, 4UHR, 2YDO, 4UG2
0.1 0.66 0.25
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55 R
A
1 1 23
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 5OLZ, 5OM1, 5MZJ, 5OLH, 5OLV, 5MZP, 5NM2
0.05 0.21 1.81 1 2
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59 R
S
1 1 24
2YCW, 4AMI, 4BVN, 2Y03, 5F8U, 2YCX, 2YCZ, 6H7J, 6H7M, 4GPO, 6H7L, 5A8E, 2Y02, 3ZPR, 6IBL, 6H7O, 2Y00, 2YCY, 2Y04, 6H7N, 2VT4, 3ZPQ, 2Y01, 4AMJ
0.23 0.21 1.81
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM2 2x52 A
L
2 1 28
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 2YDO, 5OLZ, 4UHR, 5OM1, 2YDV, 5MZJ, 5N2S, 5OLH, 4UG2, 5OLV, 5MZP, 5NM2
0.06 0 0.50 1
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48 W
K
1 1 1
5VBL
0.68 0.49 -2.09 Pos & Wild Type AA Match 22
Intermediate
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43 V
A
1 1 4
4XES, 5T04, 4GRV, 4XEE
0.1 0.61 -0.46
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54 M
A
1 1 1
5EE7
0.07 0.24 -0.67
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51 F
A
1 1 2
4Z9G, 4K5Y
0.93 0.54 -1.71 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64 M
A
1 1 3
5NDD, 5NDZ, 5NJ6
0.01 0.24 -0.67 1 3
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67 V
A
1 1 1
5X33
0.02 0.61 -0.46 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36 V
A
1 1 1
5LWE
0.15 0.61 -0.46 2 1 5
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48 S
A
1 1 2
4Z9G, 4K5Y
0.07 0.50 0.46
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM3 3x36 T
A
2 1 24
5IU7, 5NM4, 5N2R, 3UZC, 5IUA, 5IUB, 5OLO, 5OLG, 3REY, 5OM4, 3UZA, 3RFM, 3PWH, 5NLX, 5IU8, 5IU4, 5OLZ, 5OM1, 5MZJ, 5N2S, 5OLH, 5OLV, 5MZP, 5NM2
0.05 0.66 0.25 18
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon