Stabilising Mutation Analyser

Group by: Mutant Subsets: Only show mutations present in minimum 2 GPCRs
STATE TARGETS MUTATIONS FREQUENCY SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS
No. Receptor Families
No. Structures
PDBs Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A
1 1 3
5NJ6, 5NDZ, 5NDD
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y
2 1 5
5DGY, 6CMO, 4A4M, 4ZWJ, 5W0P
1 1
Inactive
Active
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
Cannabinoid
LPAR1
CNR1
CB1
LPA1
TM5 5x37
D
E
C
K
2 2 4
5XRA, 4Z36, 5XR8, 5TGZ
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C
1 1 2
5VEW, 5VEX
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLR
CRFR1
glucagon
CRF1
TM2 2x48
A
S
A
L
2 2 3
5EE7, 4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM5 5x63
Y
L
A
2 1 24
3PWH, 5MZJ, 5NLX, 5IU4, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 5OLH, 5N2S, 3UZA
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
ECL1
Q
T
D
G
L
F
A
R
E
2 1 2
5NX2, 5EE7
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM2 2x52
A
L
2 1 28
3PWH, 5MZJ, 5NLX, 5IU4, 4UG2, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 2YDO, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 4UHR, 5OLH, 5N2S, 2YDV, 3UZA
1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A
1 1 5
5CGD, 6FFH, 6FFI, 4OO9, 5CGC
Pos Match
Intermediate
A (Rhodopsin)
Lipid
Peptide
Neurotensin
Free fatty acid
FFAR1
NTR1
NTS1
FFA1
TM3 3x49
G
E
A
2 2 6
4XES, 5TZR, 4PHU, 5TZY, 4GRV, 5KW2
Pos Match 2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A
1 1 3
5NJ6, 5NDZ, 5NDD
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A
1 1 2
4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Aminergic
Peptide
Adrenoceptors
Apelin
Dopamine
ADRB1
DRD2
APJ
β1
apelin
D2
TM3 3x40
V
I
V
A
3 3 4
4BVN, 5VBL, 6CM4, 5A8E
2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A
1 1 23
3PWH, 5MZJ, 5NLX, 5IU4, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 5OLH, 3UZA
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F
1 1 1
5NX2
Inactive
Intermediate
A (Rhodopsin)
Aminergic
Lipid
Adrenoceptors
Free fatty acid
ADRB1
FFAR1
FFA1
β1
TM5 5x58
Y
F
A
2 2 22
2YCY, 2Y01, 5F8U, 4AMJ, 5TZY, 2YCZ, 4BVN, 5TZR, 3ZPQ, 2Y03, 4PHU, 2VT4, 5KW2, 5A8E, 3ZPR, 2YCW, 2Y02, 4AMI, 2Y04, 4GPO, 2YCX, 2Y00
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E
1 1 4
4MBS, 5UIW, 6AKY, 6AKX
3 1 2
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A
1 1 4
5XRA, 5XR8, 5U09, 5TGZ
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I
1 1 2
5VEW, 5VEX
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C
1 1 2
4QKX, 3PDS
10
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A
1 1 5
5CGD, 6FFH, 6FFI, 4OO9, 5CGC
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A
1 1 2
4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A
1 1 1
5LWE
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A
1 1 2
5EE7, 5YQZ
2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F
1 1 1
5EE7
1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A
1 1 4
4UHR, 2YDO, 4UG2, 2YDV
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L
1 1 3
5NJ6, 5NDZ, 5NDD
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G
1 1 1
5X33
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A
1 1 1
5EE7
Inactive
Active
Intermediate
A (Rhodopsin)
Aminergic
Protein
Adrenoceptors
5-Hydroxytryptamine
Chemokine
Dopamine
5HT2B
5HT1B
DRD3
ADRB1
CXCR4
ADRB2
CXCR4
5-HT2B
β1
β2
D3
5-HT1B
TM3 3x41
L
M
E
W
6 4 24
4IAR, 5V54, 3OE9, 6DRY, 3NY8, 3PBL, 3OE6, 5TVN, 3D4S, 6DRZ, 3OE0, 4NC3, 3ODU, 4IB4, 3NY9, 4RWS, 5A8E, 3NYA, 6DS0, 6DRX, 4IAQ, 3OE8, 5TUD, 6G79
1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K
1 1 1
4BVN
8
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A
1 1 23
3PWH, 5MZJ, 5NLX, 5IU4, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 5OLH, 3UZA
1 2
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A
1 1 1
5WF6
Pos Match 1
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A
1 1 4
4BWB, 4BUO, 4BV0, 3ZEV
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Adenosine
Dopamine
AA2AR
AA1R
DRD2
A1
D2
A2A
TM6 6x41
V
L
A
3 2 25
3PWH, 5MZJ, 5NLX, 5IU4, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 6CM4, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 5OLH, 5N2S, 3UZA
Inactive
Intermediate
A (Rhodopsin)
Aminergic
Nucleotide
Peptide
Adenosine
Neurotensin
Dopamine
AA2AR
AA1R
DRD2
NTR1
NTS1
A1
D2
A2A
TM6 6x37
L
A
4 3 26
3PWH, 5MZJ, 5NLX, 5IU4, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 4GRV, 6CM4, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 5OLH, 5N2S, 3UZA
1 1 4
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A
1 1 2
4K5Y, 4Z9G
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A
1 1 2
4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L
1 1 2
4BVN, 5A8E
Pos Match Pos Match 3
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V
1 1 24
2YCY, 6H7M, 2Y01, 5F8U, 4AMJ, 6H7J, 2YCZ, 6H7O, 4BVN, 6IBL, 6H7L, 6H7N, 3ZPQ, 2Y03, 2VT4, 3ZPR, 5A8E, 2YCW, 2Y02, 4AMI, 2Y04, 4GPO, 2YCX, 2Y00
2
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G
1 1 1
5X33
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM3 3x24
G
S
A
2 1 3
5VEW, 5EE7, 5VEX
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A
1 1 1
5LWE
6
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A
1 1 2
4K5Y, 4Z9G
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M
1 1 5
5CGD, 6FFH, 6FFI, 4OO9, 5CGC
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C
A
1 1 3
5NX2, 5VEW, 5VEX
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A
1 1 1
5NX2
2 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C
1 1 2
5VEW, 5VEX
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A
1 1 1
5LWE
4
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A
1 1 2
5XPR, 5X93
4
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C
1 1 1
4Z36
4
Intermediate
A (Rhodopsin)
Lipid
Peptide
Proteinase-activated
Free fatty acid
PAR2
FFAR1
PAR2
FFA1
TM3 3x34
F
G
A
2 2 5
5NJ6, 4PHU, 5TZR, 5NDZ, 5NDD
1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A
1 1 2
4K5Y, 4Z9G
Pos Match 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CCR9
CCR9
CXCR4
TM6 6x36
V
T
A
P
2 1 4
3OE0, 5LWE, 4RWS, 3OE9
2 1 5
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLP1R
GLR
CRFR1
GLP-1
glucagon
CRF1
TM6 6x30
Y
K
A
3 2 5
5VEW, 5EE7, 5VEX, 4K5Y, 4Z9G
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A
1 1 3
5NJ6, 5NDZ, 5NDD
1 1 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A
1 1 1
5LWE
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A
1 1 2
5VEW, 5VEX
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F
1 1 2
5L7D, 5L7I
1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A
1 1 4
4UHR, 2YDO, 4UG2, 2YDV
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C
1 1 1
5LWE
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A
1 1 4
4PHU, 5TZR, 5TZY, 5KW2
2 1 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A
1 1 1
5NX2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A
1 1 1
5LWE
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A
1 1 4
4XES, 4XEE, 5T04, 4GRV
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C
1 1 1
4RWS
16
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A
1 1 3
5NJ6, 5NDZ, 5NDD
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A
1 1 1
5EE7
Inactive
Active
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N
1 1 2
6BQH, 6BQG
Pos Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM2 2x59
I
V
F
2 1 3
5VEW, 5EE7, 5VEX
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y
1 1 4
4MBS, 5UIW, 6AKY, 6AKX
2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V
1 1 1
5NX2
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F
1 1 2
5VEW, 5VEX
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D
1 1 4
4MBS, 5UIW, 6AKY, 6AKX
2 1 6
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A
1 1 4
4UHR, 2YDO, 4UG2, 2YDV
9
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A
1 1 1
5X93
1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L
1 1 18
2YCY, 3ZPQ, 2Y01, 5F8U, 2Y03, 4AMJ, 2VT4, 2Y02, 2YCW, 3ZPR, 5A8E, 2YCZ, 4AMI, 4BVN, 2Y04, 4GPO, 2YCX, 2Y00
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A
1 1 2
5XPR, 5X93
2
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49
D
N
2 1 5
4NTJ, 4XNV, 4PXZ, 4PY0, 4XNW
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM3 3x36
T
A
2 1 24
3PWH, 5MZJ, 5NLX, 5IU4, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 5OLH, 5N2S, 3UZA
20
Inactive
Active
A (Rhodopsin)
Aminergic
Peptide
Adrenoceptors
Endothelin
ADRB1
EDNRB
β1
ETB
TM7 7x48
F
I
A
M
2 2 26
5XPR, 2YCY, 6H7M, 2Y01, 5F8U, 5X93, 4AMJ, 6H7J, 2YCZ, 6H7O, 4BVN, 6IBL, 6H7L, 6H7N, 3ZPQ, 2Y03, 2VT4, 3ZPR, 5A8E, 2YCW, 2Y02, 4AMI, 2Y04, 4GPO, 2YCX, 2Y00
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A
1 1 1
5EE7
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A
1 1 5
5CGD, 6FFH, 6FFI, 4OO9, 5CGC
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y
1 1 2
5XPR, 5X93
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A
1 1 3
5NJ6, 5NDZ, 5NDD
1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q
2 1 5
5DGY, 6CMO, 4ZWJ, 5W0P, 2X72
10
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N
1 1 4
4MBS, 5UIW, 6AKY, 6AKX
6
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A
1 1 1
5X33
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A
1 1 1
5NX2
Inactive
Active
Intermediate
A (Rhodopsin)
Sensory
Lipid
Peptide
Neurotensin
Opsins
Leukotriene
OPSD
NTR1
OPSD
Q9WTK1
NTS1
BLT1
Rhodopsin
ECL2
D
G
S
N
C
A
4 3 17
3C9M, 4XEE, 4BEZ, 4A4M, 5W0P, 4ZWJ, 6CMO, 2X72, 4XES, 5DGY, 5T04, 5X33, 5DYS, 4BEY, 4GRV, 5EN0, 2J4Y
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K
1 1 1
5VBL
Pos Match 25
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A
1 1 24
2YCY, 6H7M, 2Y01, 5F8U, 4AMJ, 6H7J, 2YCZ, 6H7O, 4BVN, 6IBL, 6H7L, 6H7N, 3ZPQ, 2Y03, 2VT4, 3ZPR, 5A8E, 2YCW, 2Y02, 4AMI, 2Y04, 4GPO, 2YCX, 2Y00
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E
1 1 3
5NJ6, 5NDZ, 5NDD
5
Inactive
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L
1 1 8
4XES, 4BWB, 5T04, 4BV0, 4XEE, 4BUO, 4GRV, 3ZEV
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM7 7x41
T
S
A
2 1 24
3PWH, 5MZJ, 5NLX, 5IU4, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 5OLH, 5N2S, 3UZA
6
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I
1 1 2
5DYS, 5EN0
19
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM2 2x56
S
C
A
2 1 3
5VEW, 5EE7, 5VEX
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A
1 1 2
4K5Y, 4Z9G
1
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S
1 1 24
2YCY, 6H7M, 2Y01, 5F8U, 4AMJ, 6H7J, 2YCZ, 6H7O, 4BVN, 6IBL, 6H7L, 6H7N, 3ZPQ, 2Y03, 2VT4, 3ZPR, 5A8E, 2YCW, 2Y02, 4AMI, 2Y04, 4GPO, 2YCX, 2Y00
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N
1 1 1
5WF5
Pos Match 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A
1 1 5
5CGD, 6FFH, 6FFI, 4OO9, 5CGC
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A
1 1 2
4K5Y, 4Z9G
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A
1 1 1
5LWE
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A
1 1 3
5NJ6, 5NDZ, 5NDD
1 3
Inactive
Intermediate
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLP1R
CRFR1
GLP-1
CRF1
ECL2 45x52
F
T
A
2 2 3
5NX2, 4K5Y, 4Z9G
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E
1 1 3
5XRA, 5XR8, 5TGZ
1 5
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y
1 1 5
5CGD, 6FFH, 6FFI, 4OO9, 5CGC
STATE TARGETS MUTATIONS FREQUENCY DATA (MUTANT) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A 1 1 2
5XPR, 5X93
0.1 0 0.50 4
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A 1 1 1
5EE7
0.27 0 0.50
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37
D
C 1 1 1
4Z36
0.68 -0.02 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V 1 1 1
5NX2
0.61 -0.46 1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y 2 1 5
5DGY, 6CMO, 4A4M, 4ZWJ, 5W0P
0.01 0.53 -0.71 1 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A 1 1 4
4UHR, 2YDO, 4UG2, 2YDV
0.03 0 0.50 9
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A 1 1 1
5NX2
0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A 1 1 5
5CGD, 6FFH, 6FFI, 4OO9, 5CGC
0.05 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A 1 1 3
5NJ6, 5NDZ, 5NDD
0.13 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A 1 1 1
5LWE
0.12 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F 1 1 2
5L7D, 5L7I
0.54 -1.71 1
Intermediate
A (Rhodopsin)
Lipid
Peptide
Proteinase-activated
Free fatty acid
PAR2
FFAR1
PAR2
FFA1
TM3 3x34
F
G
A 2 2 5
5NJ6, 4PHU, 5TZR, 5NDZ, 5NDD
0.07 0 0.50 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48
I
A 1 1 2
5XPR, 5X93
0.13 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A 1 1 3
5NJ6, 5NDZ, 5NDD
0.0 0 0.50 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A 1 1 2
5XPR, 5X93
0.07 0 0.50 2
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K 1 1 1
4BVN
0.04 0.11 0.26 2.80 8
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Adenosine
Dopamine
AA2AR
AA1R
DRD2
A1
D2
A2A
TM6 6x41
V
L
A 3 2 25
3PWH, 5MZJ, 5NLX, 5IU4, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 6CM4, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 5OLH, 5N2S, 3UZA
0.05 0 0.50
Inactive
Intermediate
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLP1R
CRFR1
GLP-1
CRF1
ECL2 45x52
F
T
A 2 2 3
5NX2, 4K5Y, 4Z9G
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A 1 1 2
4K5Y, 4Z9G
0 0.50
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM5 5x58
Y
F 1 1 4
4PHU, 5TZR, 5TZY, 5KW2
0.01 0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM3 3x24
G
S
A 2 1 3
5VEW, 5EE7, 5VEX
0.07 0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y 1 1 2
5XPR, 5X93
0.09 0.53 -0.71
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E 1 1 3
5NJ6, 5NDZ, 5NDD
0.01 0.40 0.11 5
Inactive
Active
Intermediate
A (Rhodopsin)
Aminergic
Protein
Adrenoceptors
5-Hydroxytryptamine
Chemokine
Dopamine
5HT2B
5HT1B
DRD3
ADRB1
CXCR4
ADRB2
CXCR4
5-HT2B
β1
β2
D3
5-HT1B
TM3 3x41
L
M
E
W 6 4 24
4IAR, 5V54, 3OE9, 6DRY, 3NY8, 3PBL, 3OE6, 5TVN, 3D4S, 6DRZ, 3OE0, 4NC3, 3ODU, 4IB4, 3NY9, 4RWS, 5A8E, 3NYA, 6DS0, 6DRX, 4IAQ, 3OE8, 5TUD, 6G79
0.03 0.49 -2.09 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C 1 1 1
4RWS
0.68 -0.02 16
Intermediate
A (Rhodopsin)
Lipid
Peptide
Neurotensin
Free fatty acid
FFAR1
NTR1
NTS1
FFA1
TM3 3x49
G
E
A 2 2 6
4XES, 5TZR, 4PHU, 5TZY, 4GRV, 5KW2
0.01 0 0.50 Pos & Mutant AA Match 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A 1 1 1
5LWE
0.14 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I 1 1 2
5VEW, 5VEX
0.07 0.41 -1.12
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A 1 1 24
2YCY, 6H7M, 2Y01, 5F8U, 4AMJ, 6H7J, 2YCZ, 6H7O, 4BVN, 6IBL, 6H7L, 6H7N, 3ZPQ, 2Y03, 2VT4, 3ZPR, 5A8E, 2YCW, 2Y02, 4AMI, 2Y04, 4GPO, 2YCX, 2Y00
0.1 0.11 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A 1 1 3
5NJ6, 5NDZ, 5NDD
0.14 0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N 1 1 1
5WF5
0.03 0.65 0.85 Pos & AA Mutant Match 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N 1 1 4
4MBS, 5UIW, 6AKY, 6AKX
0.03 0.65 0.85 6
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x56
S
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A 1 1 23
3PWH, 5MZJ, 5NLX, 5IU4, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 5OLH, 3UZA
0.08 0 0.50 1 2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L 1 1 3
5NJ6, 5NDZ, 5NDD
0.73 0.21 -1.25
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L 1 1 18
2YCY, 3ZPQ, 2Y01, 5F8U, 2Y03, 4AMJ, 2VT4, 2Y02, 2YCW, 3ZPR, 5A8E, 2YCZ, 4AMI, 4BVN, 2Y04, 4GPO, 2YCX, 2Y00
0.11 0.11 0.21 -1.25
Inactive
Active
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N 1 1 2
6BQH, 6BQG
0.67 0.65 0.85 Pos & AA Mutant Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A 1 1 2
5EE7, 5YQZ
0 0.50 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F 1 1 1
5NX2
0.4 0.54 -1.71
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37
E
K 1 1 3
5XRA, 5XR8, 5TGZ
0.11 0.26 2.80 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x56
S
A 1 1 1
5EE7
0.27 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A 1 1 3
5NJ6, 5NDZ, 5NDD
0.05 0 0.50 1 1 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G 1 1 1
5X33
0.67 1.00 1.15 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A 1 1 1
5EE7
0.33 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A 1 1 3
5NJ6, 5NDZ, 5NDD
0.11 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A 1 1 2
4K5Y, 4Z9G
0 0.50 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D 1 1 4
4MBS, 5UIW, 6AKY, 6AKX
0.69 0.43 2 1 6
Inactive
Active
Intermediate
A (Rhodopsin)
Lipid
Peptide
Neurotensin
Leukotriene
NTR1
Q9WTK1
NTS1
BLT1
ECL2
G
S
A 2 2 5
4XES, 4XEE, 5T04, 4GRV, 5X33
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E 1 1 3
5XRA, 5XR8, 5TGZ
0.04 0.40 0.11 1 5
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM3 3x40
I
V 1 1 2
4BVN, 5A8E
0.24 0.61 -0.46 2
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A 1 1 4
4BWB, 4BUO, 4BV0, 3ZEV
0.02 0 0.50
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C 1 1 2
4QKX, 3PDS
0.0 0.68 -0.02 10
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E 1 1 4
4MBS, 5UIW, 6AKY, 6AKX
0.12 0.40 0.11 3 1 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F 1 1 2
5VEW, 5VEX
0.07 0.54 -1.71 1
Inactive
A (Rhodopsin)
Aminergic
Peptide
Apelin
Dopamine
DRD2
APJ
apelin
D2
TM3 3x40
V
I
A 2 2 2
5VBL, 6CM4
0.06 0 0.50 2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48
S
A 1 1 2
4K5Y, 4Z9G
0.2 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLP1R
GLR
CRFR1
GLP-1
glucagon
CRF1
TM6 6x30
Y
K
A 3 2 5
5VEW, 5EE7, 5VEX, 4K5Y, 4Z9G
0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A 1 1 5
5CGD, 6FFH, 6FFI, 4OO9, 5CGC
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A 1 1 2
5VEW, 5VEX
0.07 0 0.50
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A 1 1 4
5XRA, 5XR8, 5U09, 5TGZ
0.01 0 0.50 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A 1 1 1
5LWE
0.08 0 0.50 6
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
ECL1
T
G
E 2 1 2
5NX2, 5EE7
0.40 0.11
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q 2 1 5
5DGY, 6CMO, 4ZWJ, 5W0P, 2X72
0.01 0.39 0.77 10
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48
F
M 1 1 24
2YCY, 6H7M, 2Y01, 5F8U, 4AMJ, 6H7J, 2YCZ, 6H7O, 4BVN, 6IBL, 6H7L, 6H7N, 3ZPQ, 2Y03, 2VT4, 3ZPR, 5A8E, 2YCW, 2Y02, 4AMI, 2Y04, 4GPO, 2YCX, 2Y00
0.05 0.24 -0.67
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A 1 1 2
4K5Y, 4Z9G
0 0.50 Pos & Mutant AA Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A 1 1 1
5EE7
0.07 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A 1 1 1
5NX2
0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM5 5x63
Y
L
A 2 1 24
3PWH, 5MZJ, 5NLX, 5IU4, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 5OLH, 5N2S, 3UZA
0.06 0 0.50
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A 1 1 1
5X33
0.08 0 0.50 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y 1 1 5
5CGD, 6FFH, 6FFI, 4OO9, 5CGC
0.05 0.53 -0.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A 1 1 1
5LWE
0.06 0 0.50 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A 1 1 4
4UHR, 2YDO, 4UG2, 2YDV
0.13 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A 1 1 2
4K5Y, 4Z9G
0 0.50 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A 1 1 1
5LWE
0.07 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V 1 1 24
2YCY, 6H7M, 2Y01, 5F8U, 4AMJ, 6H7J, 2YCZ, 6H7O, 4BVN, 6IBL, 6H7L, 6H7N, 3ZPQ, 2Y03, 2VT4, 3ZPR, 5A8E, 2YCW, 2Y02, 4AMI, 2Y04, 4GPO, 2YCX, 2Y00
0.23 0.33 0.61 -0.46 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
D
R 1 1 1
5NX2
0.21 1.81
Inactive
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L 1 1 8
4XES, 4BWB, 5T04, 4BV0, 4XEE, 4BUO, 4GRV, 3ZEV
0.37 0.21 -1.25
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A 1 1 5
5CGD, 6FFH, 6FFI, 4OO9, 5CGC
0 0.50 Pos & Mutant AA Match
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49
D
N 2 1 5
4NTJ, 4XNV, 4PXZ, 4PY0, 4XNW
0.72 0.65 0.85
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM7 7x41
T
S
A 2 1 24
3PWH, 5MZJ, 5NLX, 5IU4, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 5OLH, 5N2S, 3UZA
0.38 0 0.50 6
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F 1 1 1
5EE7
0.13 0.54 -1.71 1
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K 1 1 1
5VBL
0.26 2.80 Pos Match (But Not Mutant AA) 25
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A 1 1 4
4UHR, 2YDO, 4UG2, 2YDV
0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM3 3x36
T
A 2 1 24
3PWH, 5MZJ, 5NLX, 5IU4, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 5OLH, 5N2S, 3UZA
0.02 0 0.50 20
Inactive
Intermediate
A (Rhodopsin)
Aminergic
Nucleotide
Peptide
Adenosine
Neurotensin
Dopamine
AA2AR
AA1R
DRD2
NTR1
NTS1
A1
D2
A2A
TM6 6x37
L
A 4 3 26
3PWH, 5MZJ, 5NLX, 5IU4, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 4GRV, 6CM4, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 5OLH, 5N2S, 3UZA
0.04 0 0.50 1 1 4
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A 1 1 2
4K5Y, 4Z9G
0.07 0 0.50
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A 1 1 4
4PHU, 5TZR, 5TZY, 5KW2
0.06 0 0.50 2 1 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A 1 1 1
5NX2
0.07 0 0.50 2 2
Inactive
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term
D
N
C 2 1 12
3C9M, 4BEZ, 6CMO, 4A4M, 5W0P, 4ZWJ, 2X72, 5DGY, 5DYS, 4BEY, 5EN0, 2J4Y
0.68 -0.02
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A 1 1 1
5X93
0.08 0 0.50 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A 1 1 5
5CGD, 6FFH, 6FFI, 4OO9, 5CGC
0.05 0 0.50
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C 1 1 1
4Z36
0.01 0.68 -0.02 4
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I 1 1 2
5DYS, 5EN0
0.03 0.29 0.41 -1.12 19
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A 1 1 23
3PWH, 5MZJ, 5NLX, 5IU4, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 5OLH, 3UZA
0.13 0 0.50
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM2 2x52
A
L 2 1 28
3PWH, 5MZJ, 5NLX, 5IU4, 4UG2, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 2YDO, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 4UHR, 5OLH, 5N2S, 2YDV, 3UZA
0.63 0.21 -1.25 1
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A 1 1 4
4XES, 4XEE, 5T04, 4GRV
0.19 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
G
Q
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C 1 1 2
5VEW, 5VEX
0.68 -0.02 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y 1 1 4
4MBS, 5UIW, 6AKY, 6AKX
0.07 0.53 -0.71 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48
A
L 1 1 1
5EE7
0.2 0.21 -1.25
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S 1 1 24
2YCY, 6H7M, 2Y01, 5F8U, 4AMJ, 6H7J, 2YCZ, 6H7O, 4BVN, 6IBL, 6H7L, 6H7N, 3ZPQ, 2Y03, 2VT4, 3ZPR, 5A8E, 2YCW, 2Y02, 4AMI, 2Y04, 4GPO, 2YCX, 2Y00
0.04 0.50 0.46
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G 1 1 1
5X33
0.25 1.00 1.15
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C 1 1 1
5LWE
0.02 0.68 -0.02
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36
T
P 1 1 3
3OE0, 4RWS, 3OE9
0.0 3.16 0.14 2 1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A 1 1 1
5LWE
0.03 0 0.50 4
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A 1 1 3
5NJ6, 5NDZ, 5NDD
0.13 0 0.50 1 3
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2
L
F 1 1 1
5NX2
0.54 -1.71
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A 1 1 1
5WF6
0.03 0 0.50 Pos & AA Mutant Match 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M 1 1 5
5CGD, 6FFH, 6FFI, 4OO9, 5CGC
0.24 -0.67
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM2 2x59
I
V
F 2 1 3
5VEW, 5EE7, 5VEX
0.54 -1.71
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L 1 1 2
4BVN, 5A8E
0.03 0.21 -1.25 Pos Match (But Not Mutant AA) Pos & Mutant AA Match 3
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM5 5x58
Y
A 1 1 18
2YCY, 3ZPQ, 2Y01, 5F8U, 2Y03, 4AMJ, 2VT4, 2Y02, 2YCW, 3ZPR, 5A8E, 2YCZ, 4AMI, 4BVN, 2Y04, 4GPO, 2YCX, 2Y00
0.03 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36
V
A 1 1 1
5LWE
0.02 0 0.50 2 1 5
STATE TARGETS MUTATIONS FREQUENCY DATA (WILD TYPE) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48 N
Y
1 1 5
5CGD, 6FFH, 6FFI, 4OO9, 5CGC
0.41 0.65 0.85
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67 V
A
1 1 1
5X33
0.02 0.61 -0.46 1
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x34 F
A
1 1 2
4PHU, 5TZR
0.11 0.54 -1.71 1
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43 V
A
1 1 4
4XES, 4XEE, 5T04, 4GRV
0.1 0.61 -0.46
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
ECL2 G
A
1 1 4
4XES, 4XEE, 5T04, 4GRV
1.00 1.15
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48 W
K
1 1 1
5VBL
0.68 0.49 -2.09 Pos & Wild Type AA Match 25
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48 F
M
1 1 24
2YCY, 6H7M, 2Y01, 5F8U, 4AMJ, 6H7J, 2YCZ, 6H7O, 4BVN, 6IBL, 6H7L, 6H7N, 3ZPQ, 2Y03, 2VT4, 3ZPR, 5A8E, 2YCW, 2Y02, 4AMI, 2Y04, 4GPO, 2YCX, 2Y00
0.06 0.33 0.54 -1.71
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50 I
A
1 1 5
5CGD, 6FFH, 6FFI, 4OO9, 5CGC
0.5 0.41 -1.12 Pos & Wild Type AA Match
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42 T
A
1 1 5
5CGD, 6FFH, 6FFI, 4OO9, 5CGC
0.09 0.66 0.25
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x49 G
A
1 1 4
4PHU, 5TZR, 5TZY, 5KW2
0.01 1.00 1.15 Pos & Wild Type AA Match 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39 F
A
1 1 1
5EE7
0.33 0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48 S
A
1 1 2
5VEW, 5VEX
0.07 0.50 0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41 T
A
1 1 1
5LWE
0.09 0.66 0.25
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56 V
A
1 1 1
5NX2
0.07 0.61 -0.46 2 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55 R
A
1 1 23
3PWH, 5MZJ, 5NLX, 5IU4, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 5OLH, 3UZA
0.05 0.21 1.81 1 2
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM3 3x40 V
A
1 1 1
5VBL
0.24 0.61 -0.46 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 D
R
1 1 1
5NX2
0.69 0.43
Inactive
Active
Intermediate
A (Rhodopsin)
Aminergic
Protein
5-Hydroxytryptamine
Chemokine
Dopamine
DRD3
CXCR4
5HT1B
5-HT1B
D3
CXCR4
TM3 3x41 L
W
3 3 11
4IAR, 5V54, 3OE0, 3ODU, 3OE9, 4RWS, 3PBL, 3OE6, 4IAQ, 3OE8, 6G79
0.31 0.21 -1.25 1
Inactive
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
ECL3 D
C
1 1 8
2X72, 5DYS, 4BEY, 3C9M, 4BEZ, 4A4M, 5EN0, 2J4Y
0.69 0.43
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM3 3x49 E
A
1 1 2
4XES, 4GRV
0.21 0.40 0.11 Pos & Wild Type AA Match 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29 N
A
1 1 1
5LWE
0.03 0.65 0.85
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63 H
C
1 1 2
4QKX, 3PDS
0.03 0.11 0.61 0.11 10
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50 D
N
1 1 1
5WF5
0.92 0.69 0.43 Pos & Wild Type AA Match 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x34 G
A
1 1 3
5NJ6, 5NDZ, 5NDD
0.02 1.00 1.15 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50 V
A
1 1 1
5LWE
0.02 0.61 -0.46 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48 A
L
1 1 1
5EE7
0.2 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM7 7x41 T
A
1 1 1
5N2S
0.07 0.66 0.25 6
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40 V
F
1 1 2
5L7D, 5L7I
0.09 0.09 0.61 -0.46 1
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40 L
A
1 1 4
4PHU, 5TZR, 5TZY, 5KW2
0.03 0.21 -1.25 2 1 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47 H
V
1 1 1
5NX2
0.73 0.61 0.11 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53 S
A
1 1 5
5CGD, 6FFH, 6FFI, 4OO9, 5CGC
0.14 0.50 0.46
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM5 5x63 L
A
1 1 23
3PWH, 5MZJ, 5NLX, 5IU4, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 5OLH, 3UZA
0.13 0.21 -1.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47 S
C
1 1 1
5LWE
0.56 0.50 0.46
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53 M
V
1 1 24
2YCY, 6H7M, 2Y01, 5F8U, 4AMJ, 6H7J, 2YCZ, 6H7O, 4BVN, 6IBL, 6H7L, 6H7N, 3ZPQ, 2Y03, 2VT4, 3ZPR, 5A8E, 2YCW, 2Y02, 4AMI, 2Y04, 4GPO, 2YCX, 2Y00
0.07 0.33 0.24 -0.67 2
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45 G
C
A
1 1 3
5NX2, 5VEW, 5VEX
1.0 1.00 1.15
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Adenosine
Dopamine
AA1R
DRD2
A1
D2
TM6 6x41 L
A
2 2 2
5N2S, 6CM4
0.19 0.21 -1.25
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53 V
E
1 1 3
5NJ6, 5NDZ, 5NDD
0.07 0.61 -0.46 5
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM5 5x63 Y
A
1 1 1
5N2S
0.03 0.53 -0.71
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2 G
M
1 1 5
5CGD, 6FFH, 6FFI, 4OO9, 5CGC
1.00 1.15
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36 V
A
1 1 1
5LWE
0.15 0.61 -0.46 2 1 5
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
ADRB2
β1
β2
TM3 3x41 E
W
2 1 5
3NY9, 5A8E, 3NY8, 3D4S, 3NYA
0.01 0.33 0.40 0.11 1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40 M
Y
2 1 5
5DGY, 6CMO, 4A4M, 4ZWJ, 5W0P
0.05 0.71 0.24 -0.67 1 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x30 Y
A
1 1 2
4K5Y, 4Z9G
0.73 0.53 -0.71
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54 S
A
1 1 2
5XPR, 5X93
0.05 0.50 0.46 4
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2 L
F
1 1 1
5NX2
0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48 E
F
1 1 1
5EE7
0.27 0.40 0.11 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53 Y
A
1 1 2
4K5Y, 4Z9G
0.93 0.53 -0.71 Pos & Wild Type AA Match 1
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32 R
E
1 1 3
5XRA, 5XR8, 5TGZ
0.31 0.21 1.81 1 5
Inactive
Active
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45 C
N
1 1 2
6BQH, 6BQG
0.01 0.68 -0.02 Pos & Wild Type AA Match 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60 C
Y
1 1 4
4MBS, 5UIW, 6AKY, 6AKX
0.02 0.68 -0.02 2
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM2 2x52 A
L
2 1 28
3PWH, 5MZJ, 5NLX, 5IU4, 4UG2, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 2YDO, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 4UHR, 5OLH, 5N2S, 2YDV, 3UZA
0.06 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54 M
A
1 1 1
5EE7
0.07 0.24 -0.67
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42 L
A
1 1 3
5NJ6, 5NDZ, 5NDD
0.24 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM3 3x24 G
A
1 1 1
5EE7
0.4 1.00 1.15
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43 M
L
1 1 3
5NJ6, 5NDZ, 5NDD
0.05 0.24 -0.67
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63 C
A
1 1 1
5NX2
0.07 0.68 -0.02
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33 A
D
1 1 4
4MBS, 5UIW, 6AKY, 6AKX
0.29 0 0.50 2 1 6
Inactive
Intermediate
A (Rhodopsin)
Aminergic
Lipid
Adrenoceptors
Free fatty acid
ADRB1
FFAR1
FFA1
β1
TM5 5x58 Y
F
A
2 2 22
2YCY, 2Y01, 5F8U, 4AMJ, 5TZY, 2YCZ, 4BVN, 5TZR, 3ZPQ, 2Y03, 4PHU, 2VT4, 5KW2, 5A8E, 3ZPR, 2YCW, 2Y02, 4AMI, 2Y04, 4GPO, 2YCX, 2Y00
0.71 0.53 -0.71
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44 W
A
1 1 2
4K5Y, 4Z9G
0.13 0.49 -2.09
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60 T
I
1 1 2
5DYS, 5EN0
0.08 0.43 0.66 0.25 19
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46 T
A
1 1 4
5XRA, 5XR8, 5U09, 5TGZ
0.01 0.66 0.25 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52 G
I
1 1 2
5VEW, 5VEX
0.2 1.00 1.15
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 T
E
1 1 1
5NX2
0.66 0.25
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59 R
S
1 1 24
2YCY, 6H7M, 2Y01, 5F8U, 4AMJ, 6H7J, 2YCZ, 6H7O, 4BVN, 6IBL, 6H7L, 6H7N, 3ZPQ, 2Y03, 2VT4, 3ZPR, 5A8E, 2YCW, 2Y02, 4AMI, 2Y04, 4GPO, 2YCX, 2Y00
0.23 0.21 1.81
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51 I
C
1 1 2
5VEW, 5VEX
0.6 0.41 -1.12 1
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37 E
K
1 1 3
5XRA, 5XR8, 5TGZ
0.03 0.40 0.11 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53 Y
L
1 1 2
4BVN, 5A8E
0.89 1.0 0.53 -0.71 Pos & Wild Type AA Match Pos & Wild Type AA Match 3
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61 G
N
1 1 4
4MBS, 5UIW, 6AKY, 6AKX
0.02 1.00 1.15 6
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51 Y
A
1 1 3
5NJ6, 5NDZ, 5NDD
0.66 0.53 -0.71 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x24 S
A
1 1 2
5VEW, 5VEX
0.27 0.50 0.46
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48 I
A
1 1 2
5XPR, 5X93
0.15 0.41 -1.12
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46 G
A
1 1 3
5NJ6, 5NDZ, 5NDD
0.54 1.00 1.15
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27 A
L
1 1 18
2YCY, 3ZPQ, 2Y01, 5F8U, 2Y03, 4AMJ, 2VT4, 2Y02, 2YCW, 3ZPR, 5A8E, 2YCZ, 4AMI, 4BVN, 2Y04, 4GPO, 2YCX, 2Y00
0.08 0.11 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48 G
A
1 1 1
5EE7
0.13 1.00 1.15
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43 K
A
1 1 2
4K5Y, 4Z9G
0.13 0.26 2.80
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x59 I
F
1 1 2
5VEW, 5VEX
0.4 0.41 -1.12
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM2 2x56 S
C
A
2 1 3
5VEW, 5EE7, 5VEX
0.47 0.50 0.46
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28 E
Q
2 1 5
5DGY, 6CMO, 4ZWJ, 5W0P, 2X72
0.02 0.57 0.40 0.11 10
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46 L
A
1 1 4
4UHR, 2YDO, 4UG2, 2YDV
0.9 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38 S
A
1 1 2
4K5Y, 4Z9G
0.13 0.50 0.46 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39 T
A
1 1 1
5LWE
0.03 0.66 0.25 6
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37 Q
A
1 1 4
4UHR, 2YDO, 4UG2, 2YDV
0.02 0.39 0.77 9
Active
Intermediate
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2B
5-HT2B
TM3 3x41 M
W
1 1 8
6DS0, 6DRX, 4NC3, 5TVN, 4IB4, 5TUD, 6DRY, 6DRZ
0.04 0.24 -0.67 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
ECL2 45x52 F
A
1 1 2
4K5Y, 4Z9G
0.13 0.54 -1.71
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59 V
C
1 1 1
4Z36
0.12 0.61 -0.46 4
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60 L
A
1 1 2
4K5Y, 4Z9G
0.33 0.21 -1.25
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35 E
A
1 1 5
5CGD, 6FFH, 6FFI, 4OO9, 5CGC
0.09 0.40 0.11
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x59 V
F
1 1 1
5EE7
0.4 0.61 -0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49 K
E
1 1 4
4MBS, 5UIW, 6AKY, 6AKX
0.13 0.26 2.80 3 1 2
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21 K
G
1 1 1
5X33
0.01 0.26 2.80 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 Q
A
1 1 1
5NX2
0.39 0.77
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31 C
F
1 1 2
5VEW, 5VEX
0.07 0.68 -0.02 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64 M
A
1 1 3
5NJ6, 5NDZ, 5NDD
0.01 0.24 -0.67 1 3
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM7 7x41 S
A
1 1 23
3PWH, 5MZJ, 5NLX, 5IU4, 5NM2, 3UZC, 5NM4, 3RFM, 5OM4, 5OM1, 5OLZ, 5MZP, 5IU7, 5OLV, 5N2R, 5OLG, 3REY, 5OLO, 5IU8, 5IUA, 5IUB, 5OLH, 3UZA
0.16 0.50 0.46 6
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR