Stabilising Mutation Analyser

Group by: Mutant Subsets: Only show mutations present in minimum 2 GPCRs
STATE TARGETS MUTATIONS FREQUENCY SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS
No. Receptor Families
No. Structures
PDBs Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N
1 1 4
6AKX, 6AKY, 5UIW, 4MBS
6
Inactive
Intermediate
A (Rhodopsin)
Aminergic
Nucleotide
Peptide
Neurotensin
Adenosine
Dopamine
AA2AR
AA1R
DRD2
NTR1
A1
A2A
NTS1
D2
TM6 6x37
L
A
4 3 26
5IUA, 5MZJ, 5OM1, 5OLZ, 5MZP, 5IU7, 5NM4, 3PWH, 3RFM, 3UZC, 5OM4, 5N2S, 6CM4, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 4GRV, 5OLO, 3REY, 5IU8
1 1 4
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F
1 1 1
5NX2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A
1 1 1
5LWE
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A
1 1 1
5LWE
6
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K
1 1 1
5VBL
Pos Match 25
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A
1 1 1
5X33
1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A
1 1 2
4Z9G, 4K5Y
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G
1 1 1
5X33
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A
1 1 2
4Z9G, 4K5Y
1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A
1 1 23
5IUA, 5MZJ, 5OM1, 5OLZ, 5MZP, 5IU7, 5NM4, 3PWH, 3RFM, 3UZC, 5OM4, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 5OLO, 3REY, 5IU8
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L
1 1 3
5NDD, 5NJ6, 5NDZ
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A
1 1 4
4UG2, 2YDO, 4UHR, 2YDV
Intermediate
Active
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L
1 1 8
3ZEV, 5T04, 4XES, 4BWB, 4XEE, 4BUO, 4BV0, 4GRV
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A
1 1 2
5XPR, 5X93
4
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A
1 1 2
5VEW, 5VEX
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C
1 1 1
4Z36
4
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F
1 1 2
5L7I, 5L7D
1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A
1 1 5
5CGD, 5CGC, 6FFH, 6FFI, 4OO9
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A
1 1 1
5LWE
4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A
1 1 1
5LWE
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A
1 1 2
5XPR, 5X93
2
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E
1 1 3
5TGZ, 5XR8, 5XRA
1 5
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A
1 1 2
4Z9G, 4K5Y
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A
1 1 4
5TZY, 4PHU, 5KW2, 5TZR
2 1 1
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N
1 1 2
6BQH, 6BQG
Pos Match 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y
1 1 2
5XPR, 5X93
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V
1 1 1
5NX2
1
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLR
CRFR1
CRF1
glucagon
TM2 2x48
A
S
L
A
2 2 3
5EE7, 4Z9G, 4K5Y
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A
1 1 5
5CGD, 5CGC, 6FFH, 6FFI, 4OO9
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L
1 1 2
5A8E, 4BVN
Pos Match Pos Match 3
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C
1 1 1
5LWE
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
Lysophospholipid (LPA)
LPAR1
CNR1
CB1
LPA1
TM5 5x37
D
E
K
C
2 2 4
5TGZ, 5XR8, 4Z36, 5XRA
1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N
1 1 1
5WF5
Pos Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLP1R
GLR
CRFR1
CRF1
glucagon
GLP-1
TM6 6x30
K
Y
A
3 2 5
5EE7, 5VEW, 4Z9G, 5VEX, 4K5Y
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q
2 1 5
6CMO, 2X72, 4ZWJ, 5DGY, 5W0P
10
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F
1 1 1
5EE7
1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K
1 1 1
4BVN
8
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A
1 1 1
5LWE
1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A
1 1 5
5CGD, 5CGC, 6FFH, 6FFI, 4OO9
Pos Match
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A
1 1 4
5U09, 5TGZ, 5XR8, 5XRA
1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V
1 1 24
6H7J, 5F8U, 6H7N, 2Y03, 2YCW, 4AMI, 6H7L, 2Y04, 4GPO, 2YCZ, 4BVN, 2YCY, 2VT4, 5A8E, 3ZPR, 3ZPQ, 2Y01, 6IBL, 4AMJ, 6H7O, 6H7M, 2Y02, 2Y00, 2YCX
2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM3 3x24
S
G
A
2 1 3
5EE7, 5VEW, 5VEX
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A
1 1 3
5NDD, 5NJ6, 5NDZ
1 3
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A
1 1 4
4UG2, 2YDO, 4UHR, 2YDV
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I
1 1 2
5VEW, 5VEX
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A
1 1 1
5LWE
Intermediate
Active
Inactive
A (Rhodopsin)
Aminergic
Protein
5-Hydroxytryptamine
Chemokine
Dopamine
Adrenoceptors
5HT2B
5HT1B
DRD3
ADRB1
CXCR4
ADRB2
5-HT1B
β2
5-HT2B
CXCR4
D3
β1
TM3 3x41
L
M
E
W
6 4 24
6G79, 6DRY, 4IB4, 3D4S, 6DRZ, 3NYA, 3NY9, 5TUD, 5A8E, 5TVN, 3OE8, 5V54, 4NC3, 3ODU, 3OE9, 3OE0, 6DRX, 3NY8, 4IAR, 3OE6, 4RWS, 4IAQ, 3PBL, 6DS0
1
Inactive
A (Rhodopsin)
Aminergic
Peptide
Apelin
Dopamine
Adrenoceptors
ADRB1
DRD2
APJ
apelin
D2
β1
TM3 3x40
I
V
A
V
3 3 4
5VBL, 5A8E, 6CM4, 4BVN
2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A
1 1 3
5NDD, 5NJ6, 5NDZ
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C
1 1 2
5VEW, 5VEX
1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A
1 1 4
4UG2, 2YDO, 4UHR, 2YDV
9
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A
1 1 3
5NDD, 5NJ6, 5NDZ
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C
1 1 2
5VEW, 5VEX
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM2 2x52
A
L
2 1 28
5IUA, 5MZJ, 5OM1, 2YDO, 5OLZ, 5MZP, 5IU7, 2YDV, 5NM4, 3PWH, 4UHR, 3RFM, 4UG2, 3UZC, 5OM4, 5N2S, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 5OLO, 3REY, 5IU8
1
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A
1 1 4
3ZEV, 4BUO, 4BV0, 4BWB
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM7 7x41
T
S
A
2 1 24
5IUA, 5MZJ, 5OM1, 5OLZ, 5MZP, 5IU7, 5NM4, 3PWH, 3RFM, 3UZC, 5OM4, 5N2S, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 5OLO, 3REY, 5IU8
6
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A
1 1 1
5EE7
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A
1 1 1
5NX2
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C
1 1 2
4QKX, 3PDS
10
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y
1 1 5
5CGD, 5CGC, 6FFH, 6FFI, 4OO9
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C
1 1 1
4RWS
16
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y
2 1 5
6CMO, 4ZWJ, 5DGY, 5W0P, 4A4M
1 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A
1 1 2
4Z9G, 4K5Y
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A
1 1 24
6H7J, 5F8U, 6H7N, 2Y03, 2YCW, 4AMI, 6H7L, 2Y04, 4GPO, 2YCZ, 4BVN, 2YCY, 2VT4, 5A8E, 3ZPR, 3ZPQ, 2Y01, 6IBL, 4AMJ, 6H7O, 6H7M, 2Y02, 2Y00, 2YCX
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A
1 1 1
5X93
1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E
1 1 3
5NDD, 5NJ6, 5NDZ
5
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G
1 1 1
5X33
1
Intermediate
A (Rhodopsin)
Lipid
Peptide
Free fatty acid
Proteinase-activated
PAR2
FFAR1
FFA1
PAR2
TM3 3x34
F
G
A
2 2 5
5NDD, 5NJ6, 4PHU, 5NDZ, 5TZR
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D
1 1 4
6AKX, 6AKY, 5UIW, 4MBS
2 1 6
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A
1 1 2
5EE7, 5YQZ
2
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
ECL1
D
Q
L
T
G
R
F
A
E
2 1 2
5EE7, 5NX2
Intermediate
A (Rhodopsin)
Lipid
Peptide
Free fatty acid
Neurotensin
FFAR1
NTR1
FFA1
NTS1
TM3 3x49
E
G
A
2 2 6
4XES, 5TZR, 4GRV, 4PHU, 5KW2, 5TZY
Pos Match 2
Active
Inactive
A (Rhodopsin)
Aminergic
Peptide
Endothelin
Adrenoceptors
ADRB1
EDNRB
ETB
β1
TM7 7x48
F
I
M
A
2 2 26
6H7J, 5F8U, 6H7N, 2Y03, 5XPR, 2YCW, 4AMI, 5X93, 6H7L, 2Y04, 4GPO, 2YCZ, 4BVN, 2YCY, 2VT4, 5A8E, 3ZPR, 3ZPQ, 2Y01, 6IBL, 4AMJ, 6H7O, 6H7M, 2Y02, 2Y00, 2YCX
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CCR9
CCR9
CXCR4
TM6 6x36
T
V
A
P
2 1 4
4RWS, 5LWE, 3OE0, 3OE9
2 1 5
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A
1 1 2
4Z9G, 4K5Y
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E
1 1 4
6AKX, 6AKY, 5UIW, 4MBS
3 1 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM3 3x36
T
A
2 1 24
5IUA, 5MZJ, 5OM1, 5OLZ, 5MZP, 5IU7, 5NM4, 3PWH, 3RFM, 3UZC, 5OM4, 5N2S, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 5OLO, 3REY, 5IU8
20
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A
1 1 3
5NDD, 5NJ6, 5NDZ
1 1 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A
1 1 5
5CGD, 5CGC, 6FFH, 6FFI, 4OO9
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A
1 1 1
5EE7
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A
1 1 23
5IUA, 5MZJ, 5OM1, 5OLZ, 5MZP, 5IU7, 5NM4, 3PWH, 3RFM, 3UZC, 5OM4, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 5OLO, 3REY, 5IU8
1 2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A
1 1 2
4Z9G, 4K5Y
Pos Match 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A
1 1 3
5NDD, 5NJ6, 5NDZ
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A
1 1 2
4Z9G, 4K5Y
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A
1 1 2
4Z9G, 4K5Y
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A
1 1 1
5NX2
Inactive
Intermediate
A (Rhodopsin)
Aminergic
Lipid
Free fatty acid
Adrenoceptors
ADRB1
FFAR1
FFA1
β1
TM5 5x58
Y
F
A
2 2 22
5F8U, 2Y03, 2YCW, 4AMI, 2Y04, 4GPO, 2YCZ, 4BVN, 2YCY, 2VT4, 5A8E, 4PHU, 3ZPR, 5TZY, 3ZPQ, 2Y01, 5KW2, 4AMJ, 2Y02, 5TZR, 2Y00, 2YCX
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F
1 1 2
5VEW, 5VEX
1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M
1 1 5
5CGD, 5CGC, 6FFH, 6FFI, 4OO9
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A
1 1 3
5NDD, 5NJ6, 5NDZ
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A
1 1 1
5EE7
Intermediate
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A
1 1 4
5T04, 4GRV, 4XES, 4XEE
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM5 5x63
Y
L
A
2 1 24
5IUA, 5MZJ, 5OM1, 5OLZ, 5MZP, 5IU7, 5NM4, 3PWH, 3RFM, 3UZC, 5OM4, 5N2S, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 5OLO, 3REY, 5IU8
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L
1 1 18
3ZPQ, 2Y01, 5F8U, 2Y03, 4AMJ, 2YCW, 4AMI, 2Y04, 4GPO, 2YCZ, 4BVN, 2Y02, 2YCY, 5A8E, 2VT4, 2YCX, 2Y00, 3ZPR
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y
1 1 4
6AKX, 6AKY, 5UIW, 4MBS
2
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S
1 1 24
6H7J, 5F8U, 6H7N, 2Y03, 2YCW, 4AMI, 6H7L, 2Y04, 4GPO, 2YCZ, 4BVN, 2YCY, 2VT4, 5A8E, 3ZPR, 3ZPQ, 2Y01, 6IBL, 4AMJ, 6H7O, 6H7M, 2Y02, 2Y00, 2YCX
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM2 2x56
S
A
C
2 1 3
5EE7, 5VEW, 5VEX
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I
1 1 2
5DYS, 5EN0
19
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A
1 1 1
5WF6
Pos Match 1
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A
C
1 1 3
5VEW, 5VEX, 5NX2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A
1 1 1
5NX2
2 2
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLP1R
CRFR1
CRF1
GLP-1
ECL2 45x52
F
T
A
2 2 3
4Z9G, 4K5Y, 5NX2
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y12
P2Y1
TM7 7x49
D
N
2 1 5
4XNV, 4PXZ, 4NTJ, 4XNW, 4PY0
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM2 2x59
I
V
F
2 1 3
5EE7, 5VEW, 5VEX
Intermediate
Inactive
Active
A (Rhodopsin)
Lipid
Sensory
Peptide
Opsins
Neurotensin
Leukotriene
OPSD
NTR1
OPSD
Q9WTK1
NTS1
BLT1
Rhodopsin
ECL2
D
N
S
G
A
C
4 3 17
2X72, 4ZWJ, 4A4M, 5EN0, 5X33, 4XEE, 5DYS, 5T04, 4XES, 4BEY, 5W0P, 6CMO, 4GRV, 4BEZ, 3C9M, 2J4Y, 5DGY
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Adenosine
Dopamine
AA2AR
AA1R
DRD2
A1
A2A
D2
TM6 6x41
L
V
A
3 2 25
5IUA, 5MZJ, 5OM1, 5OLZ, 5MZP, 5IU7, 5NM4, 3PWH, 3RFM, 3UZC, 5OM4, 5N2S, 6CM4, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 5OLO, 3REY, 5IU8
STATE TARGETS MUTATIONS FREQUENCY DATA (MUTANT) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L 1 1 18
3ZPQ, 2Y01, 5F8U, 2Y03, 4AMJ, 2YCW, 4AMI, 2Y04, 4GPO, 2YCZ, 4BVN, 2Y02, 2YCY, 5A8E, 2VT4, 2YCX, 2Y00, 3ZPR
0.11 0.11 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A 1 1 2
4Z9G, 4K5Y
0.07 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A 1 1 5
5CGD, 5CGC, 6FFH, 6FFI, 4OO9
0.05 0 0.50
Intermediate
Active
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L 1 1 8
3ZEV, 5T04, 4XES, 4BWB, 4XEE, 4BUO, 4BV0, 4GRV
0.37 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A 1 1 2
4Z9G, 4K5Y
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A 1 1 1
5NX2
0 0.50
Intermediate
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A 1 1 4
5T04, 4GRV, 4XES, 4XEE
0.19 0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A 1 1 1
5X93
0.08 0 0.50 1
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K 1 1 1
5VBL
0.26 2.80 Pos Match (But Not Mutant AA) 25
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A 1 1 1
5X33
0.08 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48
A
L 1 1 1
5EE7
0.2 0.21 -1.25
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM7 7x41
T
S
A 2 1 24
5IUA, 5MZJ, 5OM1, 5OLZ, 5MZP, 5IU7, 5NM4, 3PWH, 3RFM, 3UZC, 5OM4, 5N2S, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 5OLO, 3REY, 5IU8
0.38 0 0.50 6
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C 1 1 1
4Z36
0.01 0.68 -0.02 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A 1 1 1
5LWE
0.14 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.11 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM5 5x63
Y
L
A 2 1 24
5IUA, 5MZJ, 5OM1, 5OLZ, 5MZP, 5IU7, 5NM4, 3PWH, 3RFM, 3UZC, 5OM4, 5N2S, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 5OLO, 3REY, 5IU8
0.06 0 0.50
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48
F
M 1 1 24
6H7J, 5F8U, 6H7N, 2Y03, 2YCW, 4AMI, 6H7L, 2Y04, 4GPO, 2YCZ, 4BVN, 2YCY, 2VT4, 5A8E, 3ZPR, 3ZPQ, 2Y01, 6IBL, 4AMJ, 6H7O, 6H7M, 2Y02, 2Y00, 2YCX
0.05 0.24 -0.67
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A 1 1 23
5IUA, 5MZJ, 5OM1, 5OLZ, 5MZP, 5IU7, 5NM4, 3PWH, 3RFM, 3UZC, 5OM4, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 5OLO, 3REY, 5IU8
0.08 0 0.50 1 2
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
ECL1
T
G
E 2 1 2
5EE7, 5NX2
0.40 0.11
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A 1 1 5
5CGD, 5CGC, 6FFH, 6FFI, 4OO9
0 0.50 Pos & Mutant AA Match
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM3 3x24
S
G
A 2 1 3
5EE7, 5VEW, 5VEX
0.07 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2
L
F 1 1 1
5NX2
0.54 -1.71
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A 1 1 4
4UG2, 2YDO, 4UHR, 2YDV
0.13 0 0.50
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N 1 1 2
6BQH, 6BQG
0.67 0.65 0.85 Pos & AA Mutant Match 1
Intermediate
A (Rhodopsin)
Lipid
Peptide
Free fatty acid
Neurotensin
FFAR1
NTR1
FFA1
NTS1
TM3 3x49
E
G
A 2 2 6
4XES, 5TZR, 4GRV, 4PHU, 5KW2, 5TZY
0.01 0 0.50 Pos & Mutant AA Match 2
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y 2 1 5
6CMO, 4ZWJ, 5DGY, 5W0P, 4A4M
0.01 0.53 -0.71 1 1
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F 1 1 2
5L7I, 5L7D
0.54 -1.71 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L 1 1 2
5A8E, 4BVN
0.03 0.21 -1.25 Pos Match (But Not Mutant AA) Pos & Mutant AA Match 3
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F 1 1 1
5NX2
0.4 0.54 -1.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D 1 1 4
6AKX, 6AKY, 5UIW, 4MBS
0.69 0.43 2 1 6
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A 1 1 23
5IUA, 5MZJ, 5OM1, 5OLZ, 5MZP, 5IU7, 5NM4, 3PWH, 3RFM, 3UZC, 5OM4, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 5OLO, 3REY, 5IU8
0.13 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F 1 1 1
5EE7
0.13 0.54 -1.71 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C 1 1 1
4RWS
0.68 -0.02 16
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLP1R
CRFR1
CRF1
GLP-1
ECL2 45x52
F
T
A 2 2 3
4Z9G, 4K5Y, 5NX2
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
D
R 1 1 1
5NX2
0.21 1.81
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A 1 1 1
5WF6
0.03 0 0.50 Pos & AA Mutant Match 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L 1 1 3
5NDD, 5NJ6, 5NDZ
0.73 0.21 -1.25
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A 1 1 1
5NX2
0.07 0 0.50 2 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A 1 1 1
5EE7
0.33 0 0.50
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S 1 1 24
6H7J, 5F8U, 6H7N, 2Y03, 2YCW, 4AMI, 6H7L, 2Y04, 4GPO, 2YCZ, 4BVN, 2YCY, 2VT4, 5A8E, 3ZPR, 3ZPQ, 2Y01, 6IBL, 4AMJ, 6H7O, 6H7M, 2Y02, 2Y00, 2YCX
0.04 0.50 0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E 1 1 4
6AKX, 6AKY, 5UIW, 4MBS
0.12 0.40 0.11 3 1 2
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M 1 1 5
5CGD, 5CGC, 6FFH, 6FFI, 4OO9
0.24 -0.67
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V 1 1 24
6H7J, 5F8U, 6H7N, 2Y03, 2YCW, 4AMI, 6H7L, 2Y04, 4GPO, 2YCZ, 4BVN, 2YCY, 2VT4, 5A8E, 3ZPR, 3ZPQ, 2Y01, 6IBL, 4AMJ, 6H7O, 6H7M, 2Y02, 2Y00, 2YCX
0.23 0.33 0.61 -0.46 2
Inactive
A (Rhodopsin)
Aminergic
Peptide
Apelin
Dopamine
DRD2
APJ
apelin
D2
TM3 3x40
I
V
A 2 2 2
5VBL, 6CM4
0.06 0 0.50 2
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I 1 1 2
5DYS, 5EN0
0.03 0.29 0.41 -1.12 19
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM2 2x59
I
V
F 2 1 3
5EE7, 5VEW, 5VEX
0.54 -1.71
Inactive
Intermediate
A (Rhodopsin)
Aminergic
Nucleotide
Peptide
Neurotensin
Adenosine
Dopamine
AA2AR
AA1R
DRD2
NTR1
A1
A2A
NTS1
D2
TM6 6x37
L
A 4 3 26
5IUA, 5MZJ, 5OM1, 5OLZ, 5MZP, 5IU7, 5NM4, 3PWH, 3RFM, 3UZC, 5OM4, 5N2S, 6CM4, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 4GRV, 5OLO, 3REY, 5IU8
0.04 0 0.50 1 1 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A 1 1 1
5LWE
0.08 0 0.50 6
Inactive
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term
D
N
C 2 1 12
2X72, 4ZWJ, 4A4M, 5EN0, 5DYS, 5W0P, 4BEY, 6CMO, 4BEZ, 3C9M, 2J4Y, 5DGY
0.68 -0.02
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G 1 1 1
5X33
0.67 1.00 1.15 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x56
S
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C 1 1 2
5VEW, 5VEX
0.68 -0.02 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A 1 1 2
4Z9G, 4K5Y
0 0.50 Pos & Mutant AA Match 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36
T
P 1 1 3
4RWS, 3OE0, 3OE9
0.0 3.16 0.14 2 1 5
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N 1 1 1
5WF5
0.03 0.65 0.85 Pos & AA Mutant Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I 1 1 2
5VEW, 5VEX
0.07 0.41 -1.12
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q 2 1 5
6CMO, 2X72, 4ZWJ, 5DGY, 5W0P
0.01 0.39 0.77 10
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A 1 1 2
5VEW, 5VEX
0.07 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x56
S
A 1 1 1
5EE7
0.27 0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A 1 1 4
4UG2, 2YDO, 4UHR, 2YDV
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.0 0 0.50 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36
V
A 1 1 1
5LWE
0.02 0 0.50 2 1 5
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F 1 1 2
5VEW, 5VEX
0.07 0.54 -1.71 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48
I
A 1 1 2
5XPR, 5X93
0.13 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N 1 1 4
6AKX, 6AKY, 5UIW, 4MBS
0.03 0.65 0.85 6
Intermediate
A (Rhodopsin)
Lipid
Peptide
Free fatty acid
Proteinase-activated
PAR2
FFAR1
FFA1
PAR2
TM3 3x34
F
G
A 2 2 5
5NDD, 5NJ6, 4PHU, 5NDZ, 5TZR
0.07 0 0.50 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y 1 1 4
6AKX, 6AKY, 5UIW, 4MBS
0.07 0.53 -0.71 2
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A 1 1 4
5TZY, 4PHU, 5KW2, 5TZR
0.06 0 0.50 2 1 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y 1 1 2
5XPR, 5X93
0.09 0.53 -0.71
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.05 0 0.50 1 1 1
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37
E
K 1 1 3
5TGZ, 5XR8, 5XRA
0.11 0.26 2.80 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM5 5x58
Y
A 1 1 18
3ZPQ, 2Y01, 5F8U, 2Y03, 4AMJ, 2YCW, 4AMI, 2Y04, 4GPO, 2YCZ, 4BVN, 2Y02, 2YCY, 5A8E, 2VT4, 2YCX, 2Y00, 3ZPR
0.03 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM2 2x52
A
L 2 1 28
5IUA, 5MZJ, 5OM1, 2YDO, 5OLZ, 5MZP, 5IU7, 2YDV, 5NM4, 3PWH, 4UHR, 3RFM, 4UG2, 3UZC, 5OM4, 5N2S, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 5OLO, 3REY, 5IU8
0.63 0.21 -1.25 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A 1 1 2
5EE7, 5YQZ
0 0.50 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A 1 1 1
5EE7
0.07 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E 1 1 3
5NDD, 5NJ6, 5NDZ
0.01 0.40 0.11 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A 1 1 1
5LWE
0.07 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A 1 1 5
5CGD, 5CGC, 6FFH, 6FFI, 4OO9
0.05 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM3 3x40
I
V 1 1 2
5A8E, 4BVN
0.24 0.61 -0.46 2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A 1 1 2
5XPR, 5X93
0.1 0 0.50 4
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C 1 1 2
4QKX, 3PDS
0.0 0.68 -0.02 10
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A 1 1 5
5CGD, 5CGC, 6FFH, 6FFI, 4OO9
0 0.50
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37
D
C 1 1 1
4Z36
0.68 -0.02 1
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y12
P2Y1
TM7 7x49
D
N 2 1 5
4XNV, 4PXZ, 4NTJ, 4XNW, 4PY0
0.72 0.65 0.85
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.13 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A 1 1 1
5LWE
0.06 0 0.50 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.13 0 0.50 1 3
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.14 0 0.50
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A 1 1 4
3ZEV, 4BUO, 4BV0, 4BWB
0.02 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
Q
G
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A 1 1 2
4Z9G, 4K5Y
0 0.50 1
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
GLP1R
GLR
CRFR1
CRF1
glucagon
GLP-1
TM6 6x30
K
Y
A 3 2 5
5EE7, 5VEW, 4Z9G, 5VEX, 4K5Y
0 0.50
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A 1 1 24
6H7J, 5F8U, 6H7N, 2Y03, 2YCW, 4AMI, 6H7L, 2Y04, 4GPO, 2YCZ, 4BVN, 2YCY, 2VT4, 5A8E, 3ZPR, 3ZPQ, 2Y01, 6IBL, 4AMJ, 6H7O, 6H7M, 2Y02, 2Y00, 2YCX
0.1 0.11 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM3 3x36
T
A 2 1 24
5IUA, 5MZJ, 5OM1, 5OLZ, 5MZP, 5IU7, 5NM4, 3PWH, 3RFM, 3UZC, 5OM4, 5N2S, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 5OLO, 3REY, 5IU8
0.02 0 0.50 20
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A 1 1 1
5LWE
0.12 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A 1 1 1
5LWE
0.03 0 0.50 4
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V 1 1 1
5NX2
0.61 -0.46 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A 1 1 1
5EE7
0.27 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y 1 1 5
5CGD, 5CGC, 6FFH, 6FFI, 4OO9
0.05 0.53 -0.71
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A 1 1 4
5U09, 5TGZ, 5XR8, 5XRA
0.01 0 0.50 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G 1 1 1
5X33
0.25 1.00 1.15
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48
S
A 1 1 2
4Z9G, 4K5Y
0.2 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C 1 1 1
5LWE
0.02 0.68 -0.02
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A 1 1 2
4Z9G, 4K5Y
0 0.50 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K 1 1 1
4BVN
0.04 0.11 0.26 2.80 8
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Adenosine
Dopamine
AA2AR
AA1R
DRD2
A1
A2A
D2
TM6 6x41
L
V
A 3 2 25
5IUA, 5MZJ, 5OM1, 5OLZ, 5MZP, 5IU7, 5NM4, 3PWH, 3RFM, 3UZC, 5OM4, 5N2S, 6CM4, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 5OLO, 3REY, 5IU8
0.05 0 0.50
Intermediate
Active
Inactive
A (Rhodopsin)
Aminergic
Protein
5-Hydroxytryptamine
Chemokine
Dopamine
Adrenoceptors
5HT2B
5HT1B
DRD3
ADRB1
CXCR4
ADRB2
5-HT1B
β2
5-HT2B
CXCR4
D3
β1
TM3 3x41
L
M
E
W 6 4 24
6G79, 6DRY, 4IB4, 3D4S, 6DRZ, 3NYA, 3NY9, 5TUD, 5A8E, 5TVN, 3OE8, 5V54, 4NC3, 3ODU, 3OE9, 3OE0, 6DRX, 3NY8, 4IAR, 3OE6, 4RWS, 4IAQ, 3PBL, 6DS0
0.03 0.49 -2.09 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A 1 1 1
5NX2
0 0.50
Intermediate
Inactive
Active
A (Rhodopsin)
Lipid
Peptide
Neurotensin
Leukotriene
NTR1
Q9WTK1
NTS1
BLT1
ECL2
S
G
A 2 2 5
5T04, 4GRV, 4XES, 4XEE, 5X33
0 0.50
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM5 5x58
Y
F 1 1 4
5TZY, 4PHU, 5KW2, 5TZR
0.01 0.54 -1.71
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E 1 1 3
5TGZ, 5XR8, 5XRA
0.04 0.40 0.11 1 5
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A 1 1 4
4UG2, 2YDO, 4UHR, 2YDV
0.03 0 0.50 9
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A 1 1 2
5XPR, 5X93
0.07 0 0.50 2
STATE TARGETS MUTATIONS FREQUENCY DATA (WILD TYPE) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31 C
F
1 1 2
5VEW, 5VEX
0.07 0.68 -0.02 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL2 45x52 T
A
1 1 1
5NX2
0.2 0.66 0.25
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48 N
Y
1 1 5
5CGD, 5CGC, 6FFH, 6FFI, 4OO9
0.41 0.65 0.85
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51 F
A
1 1 2
4Z9G, 4K5Y
0.93 0.54 -1.71 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x34 G
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.02 1.00 1.15 1
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
ECL2 G
A
E
2 1 2
5EE7, 5NX2
1.00 1.15
Inactive
Intermediate
A (Rhodopsin)
Aminergic
Nucleotide
Peptide
Neurotensin
Adenosine
Dopamine
AA2AR
AA1R
DRD2
NTR1
A1
A2A
NTS1
D2
TM6 6x37 L
A
4 3 26
5IUA, 5MZJ, 5OM1, 5OLZ, 5MZP, 5IU7, 5NM4, 3PWH, 3RFM, 3UZC, 5OM4, 5N2S, 6CM4, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 4GRV, 5OLO, 3REY, 5IU8
0.38 0.21 -1.25 1 1 4
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48 E
F
1 1 1
5EE7
0.27 0.40 0.11 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67 V
A
1 1 1
5X33
0.02 0.61 -0.46 1
Intermediate
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43 V
A
1 1 4
5T04, 4GRV, 4XES, 4XEE
0.1 0.61 -0.46
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44 W
A
1 1 2
4Z9G, 4K5Y
0.13 0.49 -2.09
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45 C
N
1 1 2
6BQH, 6BQG
0.01 0.68 -0.02 Pos & Wild Type AA Match 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
ECL2 45x52 F
A
1 1 2
4Z9G, 4K5Y
0.13 0.54 -1.71
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM5 5x63 L
A
1 1 23
5IUA, 5MZJ, 5OM1, 5OLZ, 5MZP, 5IU7, 5NM4, 3PWH, 3RFM, 3UZC, 5OM4, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 5OLO, 3REY, 5IU8
0.13 0.21 -1.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36 V
A
1 1 1
5LWE
0.15 0.61 -0.46 2 1 5
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43 M
L
1 1 3
5NDD, 5NJ6, 5NDZ
0.05 0.24 -0.67
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM3 3x24 G
A
1 1 1
5EE7
0.4 1.00 1.15
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61 G
N
1 1 4
6AKX, 6AKY, 5UIW, 4MBS
0.02 1.00 1.15 6
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
ADRB2
β1
β2
TM3 3x41 E
W
2 1 5
3D4S, 3NY9, 5A8E, 3NY8, 3NYA
0.01 0.33 0.40 0.11 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42 L
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.24 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x59 I
F
1 1 2
5VEW, 5VEX
0.4 0.41 -1.12
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51 Y
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.66 0.53 -0.71 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46 L
A
1 1 4
4UG2, 2YDO, 4UHR, 2YDV
0.9 0.21 -1.25
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36 F
A
1 1 24
6H7J, 5F8U, 6H7N, 2Y03, 2YCW, 4AMI, 6H7L, 2Y04, 4GPO, 2YCZ, 4BVN, 2YCY, 2VT4, 5A8E, 3ZPR, 3ZPQ, 2Y01, 6IBL, 4AMJ, 6H7O, 6H7M, 2Y02, 2Y00, 2YCX
0.14 0.44 0.54 -1.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50 V
A
1 1 1
5LWE
0.02 0.61 -0.46 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37 Q
A
1 1 4
4UG2, 2YDO, 4UHR, 2YDV
0.02 0.39 0.77 9
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42 T
A
1 1 5
5CGD, 5CGC, 6FFH, 6FFI, 4OO9
0.09 0.66 0.25
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 T
E
1 1 1
5NX2
0.66 0.25
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2 L
F
1 1 1
5NX2
0.21 -1.25
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53 S
A
1 1 5
5CGD, 5CGC, 6FFH, 6FFI, 4OO9
0.14 0.50 0.46
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48 I
A
1 1 2
4Z9G, 4K5Y
0.2 0.41 -1.12
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37 D
C
1 1 1
4Z36
0.01 0.69 0.43 1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63 H
C
1 1 2
4QKX, 3PDS
0.03 0.11 0.61 0.11 10
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56 V
A
1 1 1
5NX2
0.07 0.61 -0.46 2 2
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
C-term S
A
1 1 1
5X33
0.50 0.46
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64 M
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.01 0.24 -0.67 1 3
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60 L
A
1 1 2
4Z9G, 4K5Y
0.33 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36 V
A
1 1 2
4Z9G, 4K5Y
0.07 0.61 -0.46
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60 T
I
1 1 2
5DYS, 5EN0
0.08 0.43 0.66 0.25 19
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37 H
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.03 0.61 0.11 1 1 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39 T
A
1 1 1
5LWE
0.03 0.66 0.25 6
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y12
P2Y1
TM7 7x49 D
N
2 1 5
4XNV, 4PXZ, 4NTJ, 4XNW, 4PY0
0.2 0.69 0.43
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41 T
A
1 1 1
5LWE
0.09 0.66 0.25
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46 G
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.54 1.00 1.15
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38 M
A
1 1 1
5LWE
0.04 0.24 -0.67 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53 Y
L
1 1 2
5A8E, 4BVN
0.89 1.0 0.53 -0.71 Pos & Wild Type AA Match Pos & Wild Type AA Match 3
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55 R
Y
1 1 2
5XPR, 5X93
0.02 0.21 1.81
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x34 F
A
1 1 2
4PHU, 5TZR
0.11 0.54 -1.71 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39 F
A
1 1 1
5EE7
0.33 0.54 -1.71
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM7 7x41 T
A
1 1 1
5N2S
0.07 0.66 0.25 6
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x30 Y
A
1 1 2
4Z9G, 4K5Y
0.73 0.53 -0.71
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21 K
G
1 1 1
5X33
0.01 0.26 2.80 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56 D
A
1 1 1
5X93
0.01 0.69 0.43 1
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54 I
A
1 1 4
3ZEV, 4BUO, 4BV0, 4BWB
0.33 0.41 -1.12
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50 I
A
1 1 5
5CGD, 5CGC, 6FFH, 6FFI, 4OO9
0.5 0.41 -1.12 Pos & Wild Type AA Match
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 Q
A
1 1 1
5NX2
0.39 0.77
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM2 2x56 S
A
C
2 1 3
5EE7, 5VEW, 5VEX
0.47 0.50 0.46
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM5 5x63 Y
A
1 1 1
5N2S
0.03 0.53 -0.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48 G
A
1 1 1
5EE7
0.13 1.00 1.15
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40 M
Y
2 1 5
6CMO, 4ZWJ, 5DGY, 5W0P, 4A4M
0.05 0.71 0.24 -0.67 1 1
Inactive
Intermediate
A (Rhodopsin)
Aminergic
Lipid
Free fatty acid
Adrenoceptors
ADRB1
FFAR1
FFA1
β1
TM5 5x58 Y
F
A
2 2 22
5F8U, 2Y03, 2YCW, 4AMI, 2Y04, 4GPO, 2YCZ, 4BVN, 2YCY, 2VT4, 5A8E, 4PHU, 3ZPR, 5TZY, 3ZPQ, 2Y01, 5KW2, 4AMJ, 2Y02, 5TZR, 2Y00, 2YCX
0.71 0.53 -0.71
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54 S
A
1 1 2
5XPR, 5X93
0.05 0.50 0.46 4
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45 G
A
C
1 1 3
5VEW, 5VEX, 5NX2
1.0 1.00 1.15
Intermediate
Active
Inactive
A (Rhodopsin)
Aminergic
Protein
5-Hydroxytryptamine
Chemokine
Dopamine
DRD3
CXCR4
5HT1B
5-HT1B
CXCR4
D3
TM3 3x41 L
W
3 3 11
3OE8, 6G79, 5V54, 3ODU, 3OE9, 3OE0, 4IAR, 3OE6, 4RWS, 4IAQ, 3PBL
0.31 0.21 -1.25 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53 Y
A
1 1 2
4Z9G, 4K5Y
0.93 0.53 -0.71 Pos & Wild Type AA Match 1
Inactive
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term N
C
2 1 12
2X72, 4ZWJ, 4A4M, 5EN0, 5DYS, 5W0P, 4BEY, 6CMO, 4BEZ, 3C9M, 2J4Y, 5DGY
0.65 0.85
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48 T
A
1 1 1
5LWE
0.05 0.66 0.25 4
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63 C
A
1 1 1
5NX2
0.07 0.68 -0.02
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59 R
S
1 1 24
6H7J, 5F8U, 6H7N, 2Y03, 2YCW, 4AMI, 6H7L, 2Y04, 4GPO, 2YCZ, 4BVN, 2YCY, 2VT4, 5A8E, 3ZPR, 3ZPQ, 2Y01, 6IBL, 4AMJ, 6H7O, 6H7M, 2Y02, 2Y00, 2YCX
0.23 0.21 1.81
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47 H
V
1 1 1
5NX2
0.73 0.61 0.11 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48 I
A
1 1 2
5XPR, 5X93
0.15 0.41 -1.12
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47 S
C
1 1 1
5LWE
0.56 0.50 0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36 T
P
1 1 3
4RWS, 3OE0, 3OE9
0.25 0.66 0.25 2 1 5
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31 L
F
1 1 1
5NX2
0.2 0.21 -1.25
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM6 6x41 V
A
1 1 23
5IUA, 5MZJ, 5OM1, 5OLZ, 5MZP, 5IU7, 5NM4, 3PWH, 3RFM, 3UZC, 5OM4, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 5OLO, 3REY, 5IU8
0.41 0.61 -0.46
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53 V
E
1 1 3
5NDD, 5NJ6, 5NDZ
0.07 0.61 -0.46 5
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48 W
K
1 1 1
5VBL
0.68 0.49 -2.09 Pos & Wild Type AA Match 25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54 M
A
1 1 1
5EE7
0.07 0.24 -0.67
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x24 S
A
1 1 2
5VEW, 5VEX
0.27 0.50 0.46
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43 K
A
1 1 2
4Z9G, 4K5Y
0.13 0.26 2.80
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x49 G
A
1 1 4
5TZY, 4PHU, 5KW2, 5TZR
0.01 1.00 1.15 Pos & Wild Type AA Match 2
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM3 3x49 E
A
1 1 2
4GRV, 4XES
0.21 0.40 0.11 Pos & Wild Type AA Match 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39 R
A
1 1 2
5EE7, 5YQZ
1.0 0.21 1.81 2
Inactive
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
ECL3 D
C
1 1 8
2X72, 4BEY, 4A4M, 5EN0, 4BEZ, 5DYS, 3C9M, 2J4Y
0.69 0.43
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52 G
I
1 1 2
5VEW, 5VEX
0.2 1.00 1.15
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29 N
A
1 1 1
5LWE
0.03 0.65 0.85
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM6 6x30 K
A
2 1 3
5EE7, 5VEW, 5VEX
0.2 0.26 2.80
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59 V
C
1 1 1
4Z36
0.12 0.61 -0.46 4
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39 S
A
1 1 1
5WF6
0.72 0.50 0.46 Pos & Wild Type AA Match 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM3 3x36 T
A
2 1 24
5IUA, 5MZJ, 5OM1, 5OLZ, 5MZP, 5IU7, 5NM4, 3PWH, 3RFM, 3UZC, 5OM4, 5N2S, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 5OLO, 3REY, 5IU8
0.05 0.66 0.25 20
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Adenosine
Dopamine
AA1R
DRD2
A1
D2
TM6 6x41 L
A
2 2 2
5N2S, 6CM4
0.19 0.21 -1.25
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42 P
A
1 1 1
5NX2
0.93 3.16 0.14
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM7 7x41 S
A
1 1 23
5IUA, 5MZJ, 5OM1, 5OLZ, 5MZP, 5IU7, 5NM4, 3PWH, 3RFM, 3UZC, 5OM4, 5IU4, 5OLG, 5OLV, 5NM2, 5N2R, 5IUB, 5NLX, 5OLH, 3UZA, 5OLO, 3REY, 5IU8
0.16 0.50 0.46 6
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51 I
C
1 1 2
5VEW, 5VEX
0.6 0.41 -1.12 1
Inactive
A (Rhodopsin)
Aminergic
Dopamine
Adrenoceptors
ADRB1
DRD2
D2
β1
TM3 3x40 I
A
V
2 2 3
5A8E, 6CM4,