Stabilising Mutation Analyser
Group by:
Mutant Subsets: Only show mutations present in minimum 2 GPCRs
| STATE | TARGETS | MUTATIONS | FREQUENCY | SITES | INTERFACES | ||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| State | Class | Ligand Type | Receptor Family | UniProt | Receptor | Segment | Position (GN) | WT | Mut | No. GPCRS | No. Receptor Families |
No. Structures |
PDBs | Ionic Lock | Sodium Ion Binding Site | Switch | LigandBinding | Arrestin | G-PROTEIN | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x41 |
|
|
7 | 5 | 28 |
5ZBQ,
4IAR,
3NYA,
6DRZ,
3OE8,
9F33,
5TUD,
4RWS,
5V54,
3OE0,
3NY9,
3PBL,
3NY8,
5ZBH,
4IAQ,
3OE6,
5TVN,
3ODU,
7C61,
9F34,
4IB4,
3OE9,
6DRX,
3D4S,
5A8E,
4NC3,
6DRY,
6DS0
|
— | — | — | 8 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x45 |
|
|
1 | 1 | 2 |
6BQH,
6BQG
|
— | Pos Match | — | 5 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x52 |
|
|
2 | 1 | 28 |
5IUA,
5IU4,
5IUB,
2YDV,
5IU8,
5OLZ,
5MZP,
5N2S,
5NLX,
5OLO,
3RFM,
2YDO,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
4UG2,
5OM4,
5NM2,
5IU7,
5OM1,
4UHR,
5MZJ,
5N2R,
3UZA
|
— | — | — | 2 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x36 |
|
|
2 | 1 | 24 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5N2S,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
— | — | — | 116 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x63 |
|
|
2 | 1 | 24 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5N2S,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x37 |
|
|
4 | 3 | 26 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5N2S,
5NLX,
5OLO,
3RFM,
4GRV,
6CM4,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
— | — | — | 7 | 1 | 4 | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x41 |
|
|
3 | 2 | 25 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5N2S,
5NLX,
5OLO,
3RFM,
6CM4,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
— | — | — | 2 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x41 |
|
|
2 | 1 | 24 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5N2S,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
— | — | — | 63 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x46 |
|
|
1 | 1 | 4 |
4UHR,
2YDO,
4UG2,
2YDV
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x50 |
|
|
1 | 1 | 1 |
5WF5
|
— | Pos Match | — | 3 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x62 |
|
|
1 | 1 | 4 |
4UHR,
2YDO,
4UG2,
2YDV
|
— | — | — | 6 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x37 |
|
|
1 | 1 | 4 |
4UHR,
2YDO,
4UG2,
2YDV
|
— | — | — | 68 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x55 |
|
|
1 | 1 | 23 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
— | — | — | — | 1 | 2 | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM4 | 4x43 |
|
|
1 | 1 | 23 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
— | — | — | 1 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM1 | 1x59 |
|
|
1 | 1 | 24 |
4AMI,
2YCZ,
4AMJ,
4BVN,
5F8U,
3ZPR,
6H7J,
2Y00,
2YCY,
2YCW,
6H7O,
2Y03,
2YCX,
2Y04,
6H7N,
6H7L,
6H7M,
3ZPQ,
2Y01,
6IBL,
5A8E,
2Y02,
2VT4,
4GPO
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x53 |
|
|
1 | 1 | 25 |
4AMI,
2YCZ,
4AMJ,
4BVN,
5F8U,
3ZPR,
6H7J,
2Y00,
2YCY,
2YCW,
6H7O,
6TKO,
2Y03,
2YCX,
2Y04,
6H7N,
6H7L,
6H7M,
3ZPQ,
2Y01,
6IBL,
5A8E,
2Y02,
2VT4,
4GPO
|
— | — | — | 24 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x40 |
|
|
3 | 3 | 4 |
5A8E,
4BVN,
6CM4,
5VBL
|
— | — | — | 20 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x58 |
|
|
2 | 2 | 22 |
5TZY,
4AMI,
2YCZ,
4AMJ,
4BVN,
5F8U,
3ZPR,
2Y00,
2YCY,
2YCW,
2Y03,
2YCX,
2Y04,
5TZR,
4PHU,
5KW2,
3ZPQ,
2Y01,
5A8E,
2Y02,
2VT4,
4GPO
|
— | — | — | 4 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x27 |
|
|
1 | 1 | 18 |
2YCX,
4AMI,
2YCZ,
4AMJ,
4BVN,
3ZPQ,
2YCW,
3ZPR,
2Y01,
2Y00,
5F8U,
5A8E,
2Y02,
2YCY,
2VT4,
4GPO,
2Y03,
2Y04
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x31 |
|
|
1 | 1 | 1 |
4BVN
|
— | — | — | 67 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x36 |
|
|
1 | 1 | 25 |
4AMI,
2YCZ,
4AMJ,
4BVN,
5F8U,
3ZPR,
6H7J,
2Y00,
2YCY,
2YCW,
6H7O,
6TKO,
2Y03,
2YCX,
2Y04,
6H7N,
6H7L,
6H7M,
3ZPQ,
2Y01,
6IBL,
5A8E,
2Y02,
2VT4,
4GPO
|
— | — | — | 3 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x48 |
|
|
2 | 2 | 27 |
5X93,
4AMI,
2YCZ,
4AMJ,
4BVN,
5F8U,
3ZPR,
6H7J,
2Y00,
2YCY,
2YCW,
6H7O,
6TKO,
2Y03,
5XPR,
2YCX,
2Y04,
6H7N,
6H7L,
6H7M,
3ZPQ,
2Y01,
6IBL,
5A8E,
2Y02,
2VT4,
4GPO
|
— | — | — | 1 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x53 |
|
|
1 | 1 | 2 |
5A8E,
4BVN
|
— | Pos Match | Pos Match | 8 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x63 |
|
|
1 | 1 | 2 |
4QKX,
3PDS
|
— | — | — | 71 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x48 |
|
|
1 | 1 | 1 |
5VBL
|
— | Pos Match | — | 84 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM1 | 1x60 |
|
|
1 | 1 | 5 |
5UIW,
6AKX,
6AKY,
4MBS,
7F1T
|
— | — | — | 1 | — | 2 | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM4 | 4x61 |
|
|
1 | 1 | 8 |
5UIW,
7F1Q,
6AKX,
6AKY,
7F1S,
4MBS,
7F1R,
7F1T
|
— | — | — | 49 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x33 |
|
|
1 | 1 | 5 |
5UIW,
6AKX,
6AKY,
4MBS,
7F1T
|
— | — | — | 4 | 1 | 6 | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
H8 | 8x49 |
|
|
1 | 1 | 5 |
5UIW,
6AKX,
6AKY,
4MBS,
7F1T
|
— | — | — | 4 | 1 | 2 | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
ICL1 | 12x48 |
|
|
1 | 1 | 1 |
5LWE
|
— | — | — | — | — | 4 | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
ICL1 | 12x50 |
|
|
1 | 1 | 1 |
5LWE
|
— | — | — | 2 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x38 |
|
|
1 | 1 | 1 |
5LWE
|
— | — | — | — | 1 | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x47 |
|
|
1 | 1 | 1 |
5LWE
|
— | — | — | 1 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x41 |
|
|
1 | 1 | 1 |
5LWE
|
— | — | — | 3 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x36 |
|
|
2 | 1 | 4 |
3OE0,
5LWE,
4RWS,
3OE9
|
— | — | — | 6 | 1 | 5 | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x29 |
|
|
1 | 1 | 1 |
5LWE
|
— | — | — | 2 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x39 |
|
|
1 | 1 | 1 |
5LWE
|
— | — | — | 20 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x46 |
|
|
1 | 1 | 4 |
5XR8,
5XRA,
5TGZ,
5U09
|
— | — | — | 1 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x37 |
|
|
2 | 2 | 4 |
4Z36,
5XRA,
5TGZ,
5XR8
|
— | — | — | 8 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x32 |
|
|
1 | 1 | 3 |
5XRA,
5TGZ,
5XR8
|
— | — | — | — | 1 | 5 | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
ECL2 | 45x51 |
|
|
1 | 1 | 1 |
4RWS
|
— | — | — | 111 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM1 | 1x55 |
|
|
1 | 1 | 2 |
5X93,
5XPR
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x56 |
|
|
1 | 1 | 1 |
5X93
|
— | — | — | 22 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x36 |
|
|
1 | 1 | 2 |
5X93,
5XPR
|
— | — | — | 49 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x54 |
|
|
1 | 1 | 2 |
5X93,
5XPR
|
— | — | — | 31 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x40 |
|
|
1 | 1 | 4 |
5KW2,
5TZY,
5TZR,
4PHU
|
— | — | — | 4 | 1 | 1 | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x34 |
|
|
2 | 2 | 6 |
5NDD,
5TZR,
4PHU,
5NJ6,
5NDZ,
5KW2
|
— | — | — | 3 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x49 |
|
|
2 | 2 | 6 |
5TZY,
5TZR,
4PHU,
4XES,
5KW2,
4GRV
|
Pos Match | — | — | 2 | — | 2 | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x59 |
|
|
1 | 1 | 1 |
4Z36
|
— | — | — | 32 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM1 | 1x54 |
|
|
1 | 1 | 22 |
6Z4Q,
6ZIN,
4BV0,
6Z66,
4BUO,
6Z8N,
6Z4V,
8FN0,
4XEE,
3ZEV,
4GRV,
8FMZ,
7L0S,
7L0P,
4XES,
6YVR,
4BWB,
7L0R,
5T04,
6Z4S,
6ZA8,
7L0Q
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
ECL2 | — |
|
|
4 | 3 | 24 |
6FKB,
4BEY,
5X33,
6FK9,
3C9M,
6FKD,
5DYS,
6FK6,
4ZWJ,
4XEE,
4GRV,
5DGY,
5EN0,
4BEZ,
6FK7,
5W0P,
6FK8,
4XES,
2X72,
6FKA,
6FKC,
2J4Y,
5T04,
4A4M
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x54 |
|
|
1 | 1 | 4 |
4BUO,
3ZEV,
4BV0,
4BWB
|
— | — | — | 4 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x43 |
|
|
1 | 1 | 4 |
4XES,
4XEE,
5T04,
4GRV
|
— | — | — | 2 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x60 |
|
|
1 | 1 | 2 |
5EN0,
5DYS
|
— | — | — | 96 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x28 |
|
|
2 | 1 | 4 |
5DGY,
2X72,
5W0P,
4ZWJ
|
— | — | — | 57 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x40 |
|
|
2 | 1 | 4 |
5DGY,
5W0P,
4ZWJ,
4A4M
|
— | — | — | 2 | 1 | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x49 |
|
|
2 | 1 | 6 |
4PXZ,
4XNW,
4XNV,
4NTJ,
4PY0,
7PP1
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM1 | 1x46 |
|
|
1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x37 |
|
|
1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
— | — | — | 3 | 1 | 1 | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x43 |
|
|
1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
— | — | — | 2 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x51 |
|
|
1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
— | — | — | 1 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x53 |
|
|
1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
— | — | — | — | — | 5 | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x64 |
|
|
1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
— | — | — | — | 1 | 3 | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x38 |
|
|
1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
— | — | — | 4 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x42 |
|
|
1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
— | — | — | 1 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x34 |
|
|
1 | 1 | 2 |
5ZKQ,
5ZKP
|
— | — | — | 2 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x67 |
|
|
1 | 1 | 1 |
5X33
|
— | — | — | 15 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x21 |
|
|
1 | 1 | 1 |
5X33
|
— | — | — | 7 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x67 |
|
|
1 | 1 | 1 |
5X33
|
— | — | — | — | — | 1 | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM1 | 1x36 |
|
|
1 | 1 | 5 |
8GTG,
4K5Y,
8GTM,
4Z9G,
8GTI
|
— | — | — | 13 | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM1 | 1x60 |
|
|
1 | 1 | 5 |
8GTG,
4K5Y,
8GTM,
4Z9G,
8GTI
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM2 | 2x44 |
|
|
1 | 1 | 2 |
4Z9G,
4K5Y
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM2 | 2x48 |
|
|
2 | 2 | 3 |
5EE7,
4Z9G,
4K5Y
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM4 | 4x43 |
|
|
1 | 1 | 2 |
4Z9G,
4K5Y
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
ECL2 | 45x52 |
|
|
2 | 2 | 3 |
4Z9G,
4K5Y,
5NX2
|
— | — | — | 15 | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM5 | 5x48 |
|
|
1 | 1 | 2 |
4Z9G,
4K5Y
|
— | — | — | 6 | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x30 |
|
|
3 | 2 | 5 |
5VEX,
4K5Y,
5EE7,
5VEW,
4Z9G
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x51 |
|
|
1 | 1 | 2 |
4Z9G,
4K5Y
|
— | — | — | 3 | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM7 | 7x38 |
|
|
1 | 1 | 2 |
4Z9G,
4K5Y
|
— | — | — | 15 | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM7 | 7x53 |
|
|
1 | 1 | 2 |
4Z9G,
4K5Y
|
— | — | Pos Match | 1 | — | 1 | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM2 | 2x56 |
|
|
2 | 1 | 3 |
5EE7,
5VEW,
5VEX
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM2 | 2x59 |
|
|
2 | 1 | 3 |
5EE7,
5VEW,
5VEX
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
ECL1 | — |
|
|
2 | 1 | 2 |
5EE7,
5NX2
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM3 | 3x24 |
|
|
2 | 1 | 3 |
5EE7,
5VEW,
5VEX
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM3 | 3x31 |
|
|
1 | 1 | 1 |
5NX2
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM3 | 3x32 |
|
|
1 | 1 | 2 |
5VEW,
5VEX
|
— | — | — | 12 | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM4 | 4x48 |
|
|
1 | 1 | 2 |
5VEW,
5VEX
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM5 | 5x51 |
|
|
1 | 1 | 2 |
5VEW,
5VEX
|
— | — | — | 1 | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM5 | 5x52 |
|
|
1 | 1 | 2 |
5VEW,
5VEX
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM5 | 5x63 |
|
|
1 | 1 | 1 |
5NX2
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x31 |
|
|
1 | 1 | 2 |
5VEW,
5VEX
|
— | — | — | 1 | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x42 |
|
|
1 | 1 | 1 |
5NX2
|
— | — | — | 2 | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x45 |
|
|
1 | 1 | 3 |
5VEW,
5VEX,
5NX2
|
— | — | — | 1 | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x47 |
|
|
1 | 1 | 1 |
5NX2
|
— | — | — | 2 | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM7 | 7x56 |
|
|
1 | 1 | 1 |
5NX2
|
— | — | — | 1 | — | 2 | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM1 | 1x48 |
|
|
1 | 1 | 1 |
5EE7
|
— | — | — | 2 | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM2 | 2x39 |
|
|
1 | 1 | 2 |
5EE7,
5YQZ
|
— | — | — | 1 | — | 2 | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM4 | 4x54 |
|
|
1 | 1 | 1 |
5EE7
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x48 |
|
|
1 | 1 | 1 |
5EE7
|
— | — | — | 6 | — | — | ||||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM7 | 7x39 |
|
|
1 | 1 | 1 |
5EE7
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
C (Glutamate) |
|
|
|
|
TM1 | 1x35 |
|
|
1 | 1 | 6 |
5CGD,
6FFH,
6FFI,
4OO9,
5CGC,
7P2L
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
C (Glutamate) |
|
|
|
|
TM3 | 3x48 |
|
|
1 | 1 | 6 |
5CGD,
6FFH,
6FFI,
4OO9,
5CGC,
7P2L
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
C (Glutamate) |
|
|
|
|
TM3 | 3x50 |
|
|
1 | 1 | 6 |
5CGD,
6FFH,
6FFI,
4OO9,
5CGC,
7P2L
|
Pos Match | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
C (Glutamate) |
|
|
|
|
ICL2 | — |
|
|
1 | 1 | 6 |
5CGD,
6FFH,
6FFI,
4OO9,
5CGC,
7P2L
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
C (Glutamate) |
|
|
|
|
TM5 | 5x42 |
|
|
1 | 1 | 15 |
7FD9,
6FFH,
8X0D,
8X0G,
5CGC,
8X0E,
8X0F,
7FD8,
5CGD,
6FFI,
8X0B,
8X0H,
8X0C,
4OO9,
7P2L
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
C (Glutamate) |
|
|
|
|
TM5 | 5x53 |
|
|
1 | 1 | 15 |
7FD9,
6FFH,
8X0D,
8X0G,
5CGC,
8X0E,
8X0F,
7FD8,
5CGD,
6FFI,
8X0B,
8X0H,
8X0C,
4OO9,
7P2L
|
— | — | — | — | — | — | ||||||||||||||||||||||||||||||
|
F (Frizzled) |
|
|
|
|
TM3 | 3x40 |
|
|
1 | 1 | 2 |
5L7D,
5L7I
|
— | — | — | 1 | — | — | ||||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x39 |
|
|
1 | 1 | 1 |
5WF6
|
— | Pos Match | — | 5 | — | — | ||||||||||||||||||||||||||||||
| STATE | TARGETS | MUTATIONS | FREQUENCY | DATA (MUTANT) | SITES | INTERFACES | ||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| State | Class | Ligand Type | Receptor Family | UniProt | Receptor | Segment | Position (GN) | WT | Mut | No. GPCRS | No. Receptor Families | No. Structures | PDBs | Class Sequence Conservation | Receptor Family Sequence Conservation | Helix Propen- sity | Hydroph- obicity | Ionic Lock | Sodium Ion Binding Site | Switch | LigandBinding | Arrestin | G-PROTEIN | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x41 |
|
W | 7 | 5 | 28 |
5ZBQ,
4IAR,
3NYA,
6DRZ,
3OE8,
9F33,
5TUD,
4RWS,
5V54,
3OE0,
3NY9,
3PBL,
3NY8,
5ZBH,
4IAQ,
3OE6,
5TVN,
3ODU,
7C61,
9F34,
4IB4,
3OE9,
6DRX,
3D4S,
5A8E,
4NC3,
6DRY,
6DS0
|
0.03 | — | 0.49 | -2.09 | — | — | — | 8 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x45 |
|
N | 1 | 1 | 2 |
6BQH,
6BQG
|
0.67 | — | 0.65 | 0.85 | — | Pos & AA Mutant Match | — | 5 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x52 |
|
L | 2 | 1 | 28 |
5IUA,
5IU4,
5IUB,
2YDV,
5IU8,
5OLZ,
5MZP,
5N2S,
5NLX,
5OLO,
3RFM,
2YDO,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
4UG2,
5OM4,
5NM2,
5IU7,
5OM1,
4UHR,
5MZJ,
5N2R,
3UZA
|
0.63 | — | 0.21 | -1.25 | — | — | — | 2 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x36 |
|
A | 2 | 1 | 24 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5N2S,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
0.02 | — | 0 | 0.50 | — | — | — | 116 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x63 |
|
A | 2 | 1 | 24 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5N2S,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
0.05 | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x37 |
|
A | 4 | 3 | 26 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5N2S,
5NLX,
5OLO,
3RFM,
4GRV,
6CM4,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
0.04 | — | 0 | 0.50 | — | — | — | 7 | 1 | 4 | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x41 |
|
A | 3 | 2 | 25 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5N2S,
5NLX,
5OLO,
3RFM,
6CM4,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
0.05 | — | 0 | 0.50 | — | — | — | 2 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x41 |
|
A | 2 | 1 | 24 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5N2S,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
0.38 | — | 0 | 0.50 | — | — | — | 63 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x46 |
|
A | 1 | 1 | 4 |
4UHR,
2YDO,
4UG2,
2YDV
|
— | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x50 |
|
N | 1 | 1 | 1 |
5WF5
|
0.03 | — | 0.65 | 0.85 | — | Pos & AA Mutant Match | — | 3 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x62 |
|
A | 1 | 1 | 4 |
4UHR,
2YDO,
4UG2,
2YDV
|
0.12 | — | 0 | 0.50 | — | — | — | 6 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x37 |
|
A | 1 | 1 | 4 |
4UHR,
2YDO,
4UG2,
2YDV
|
0.03 | — | 0 | 0.50 | — | — | — | 68 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x55 |
|
A | 1 | 1 | 23 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
0.08 | — | 0 | 0.50 | — | — | — | — | 1 | 2 | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM4 | 4x43 |
|
A | 1 | 1 | 23 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
0.13 | — | 0 | 0.50 | — | — | — | 1 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM1 | 1x59 |
|
S | 1 | 1 | 24 |
4AMI,
2YCZ,
4AMJ,
4BVN,
5F8U,
3ZPR,
6H7J,
2Y00,
2YCY,
2YCW,
6H7O,
2Y03,
2YCX,
2Y04,
6H7N,
6H7L,
6H7M,
3ZPQ,
2Y01,
6IBL,
5A8E,
2Y02,
2VT4,
4GPO
|
0.04 | — | 0.50 | 0.46 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x53 |
|
V | 1 | 1 | 25 |
4AMI,
2YCZ,
4AMJ,
4BVN,
5F8U,
3ZPR,
6H7J,
2Y00,
2YCY,
2YCW,
6H7O,
6TKO,
2Y03,
2YCX,
2Y04,
6H7N,
6H7L,
6H7M,
3ZPQ,
2Y01,
6IBL,
5A8E,
2Y02,
2VT4,
4GPO
|
0.23 | 0.33 | 0.61 | -0.46 | — | — | — | 24 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x40 |
|
V | 1 | 1 | 2 |
5A8E,
4BVN
|
0.24 | — | 0.61 | -0.46 | — | — | — | 20 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x58 |
|
A | 1 | 1 | 18 |
2YCX,
4AMI,
2YCZ,
4AMJ,
4BVN,
3ZPQ,
2YCW,
3ZPR,
2Y01,
2Y00,
5F8U,
5A8E,
2Y02,
2YCY,
2VT4,
4GPO,
2Y03,
2Y04
|
0.02 | — | 0 | 0.50 | — | — | — | 4 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x27 |
|
L | 1 | 1 | 18 |
2YCX,
4AMI,
2YCZ,
4AMJ,
4BVN,
3ZPQ,
2YCW,
3ZPR,
2Y01,
2Y00,
5F8U,
5A8E,
2Y02,
2YCY,
2VT4,
4GPO,
2Y03,
2Y04
|
0.12 | 0.11 | 0.21 | -1.25 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x31 |
|
K | 1 | 1 | 1 |
4BVN
|
0.04 | 0.11 | 0.26 | 2.80 | — | — | — | 67 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x36 |
|
A | 1 | 1 | 25 |
4AMI,
2YCZ,
4AMJ,
4BVN,
5F8U,
3ZPR,
6H7J,
2Y00,
2YCY,
2YCW,
6H7O,
6TKO,
2Y03,
2YCX,
2Y04,
6H7N,
6H7L,
6H7M,
3ZPQ,
2Y01,
6IBL,
5A8E,
2Y02,
2VT4,
4GPO
|
0.1 | 0.11 | 0 | 0.50 | — | — | — | 3 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x48 |
|
M | 1 | 1 | 25 |
4AMI,
2YCZ,
4AMJ,
4BVN,
5F8U,
3ZPR,
6H7J,
2Y00,
2YCY,
2YCW,
6H7O,
6TKO,
2Y03,
2YCX,
2Y04,
6H7N,
6H7L,
6H7M,
3ZPQ,
2Y01,
6IBL,
5A8E,
2Y02,
2VT4,
4GPO
|
0.05 | — | 0.24 | -0.67 | — | — | — | 1 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x53 |
|
L | 1 | 1 | 2 |
5A8E,
4BVN
|
0.03 | — | 0.21 | -1.25 | — | Pos Match (But Not Mutant AA) | Pos & Mutant AA Match | 8 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x63 |
|
C | 1 | 1 | 2 |
4QKX,
3PDS
|
— | — | 0.68 | -0.02 | — | — | — | 71 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x40 |
|
A | 2 | 2 | 2 |
6CM4,
5VBL
|
0.06 | — | 0 | 0.50 | — | — | — | 20 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x48 |
|
K | 1 | 1 | 1 |
5VBL
|
— | — | 0.26 | 2.80 | — | Pos Match (But Not Mutant AA) | — | 84 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM1 | 1x60 |
|
Y | 1 | 1 | 5 |
5UIW,
6AKX,
6AKY,
4MBS,
7F1T
|
0.08 | — | 0.53 | -0.71 | — | — | — | 1 | — | 2 | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM4 | 4x61 |
|
N | 1 | 1 | 8 |
5UIW,
7F1Q,
6AKX,
6AKY,
7F1S,
4MBS,
7F1R,
7F1T
|
0.04 | — | 0.65 | 0.85 | — | — | — | 49 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x33 |
|
D | 1 | 1 | 5 |
5UIW,
6AKX,
6AKY,
4MBS,
7F1T
|
— | — | 0.69 | 0.43 | — | — | — | 4 | 1 | 6 | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
H8 | 8x49 |
|
E | 1 | 1 | 5 |
5UIW,
6AKX,
6AKY,
4MBS,
7F1T
|
0.12 | — | 0.40 | 0.11 | — | — | — | 4 | 1 | 2 | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
ICL1 | 12x48 |
|
A | 1 | 1 | 1 |
5LWE
|
0.04 | — | 0 | 0.50 | — | — | — | — | — | 4 | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
ICL1 | 12x50 |
|
A | 1 | 1 | 1 |
5LWE
|
0.07 | — | 0 | 0.50 | — | — | — | 2 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x38 |
|
A | 1 | 1 | 1 |
5LWE
|
0.12 | — | 0 | 0.50 | — | — | — | — | 1 | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x47 |
|
C | 1 | 1 | 1 |
5LWE
|
0.02 | — | 0.68 | -0.02 | — | — | — | 1 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x41 |
|
A | 1 | 1 | 1 |
5LWE
|
0.07 | — | 0 | 0.50 | — | — | — | 3 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x36 |
|
A | 1 | 1 | 1 |
5LWE
|
0.01 | — | 0 | 0.50 | — | — | — | 6 | 1 | 5 | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x29 |
|
A | 1 | 1 | 1 |
5LWE
|
0.15 | — | 0 | 0.50 | — | — | — | 2 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x39 |
|
A | 1 | 1 | 1 |
5LWE
|
0.08 | — | 0 | 0.50 | — | — | — | 20 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x46 |
|
A | 1 | 1 | 4 |
5XR8,
5XRA,
5TGZ,
5U09
|
0.01 | — | 0 | 0.50 | — | — | — | 1 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x37 |
|
K | 1 | 1 | 3 |
5XRA,
5TGZ,
5XR8
|
0.11 | — | 0.26 | 2.80 | — | — | — | 8 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x32 |
|
E | 1 | 1 | 3 |
5XRA,
5TGZ,
5XR8
|
0.04 | — | 0.40 | 0.11 | — | — | — | — | 1 | 5 | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
ECL2 | 45x51 |
|
C | 1 | 1 | 1 |
4RWS
|
— | — | 0.68 | -0.02 | — | — | — | 111 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x36 |
|
P | 1 | 1 | 3 |
3OE0,
4RWS,
3OE9
|
0.0 | — | 3.16 | 0.14 | — | — | — | 6 | 1 | 5 | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM1 | 1x55 |
|
Y | 1 | 1 | 2 |
5X93,
5XPR
|
0.09 | — | 0.53 | -0.71 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x56 |
|
A | 1 | 1 | 1 |
5X93
|
0.08 | — | 0 | 0.50 | — | — | — | 22 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x36 |
|
A | 1 | 1 | 2 |
5X93,
5XPR
|
0.06 | — | 0 | 0.50 | — | — | — | 49 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x54 |
|
A | 1 | 1 | 2 |
5X93,
5XPR
|
0.1 | — | 0 | 0.50 | — | — | — | 31 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x48 |
|
A | 1 | 1 | 2 |
5X93,
5XPR
|
0.13 | — | 0 | 0.50 | — | — | — | 1 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x40 |
|
A | 1 | 1 | 4 |
5KW2,
5TZY,
5TZR,
4PHU
|
0.06 | — | 0 | 0.50 | — | — | — | 4 | 1 | 1 | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x34 |
|
A | 2 | 2 | 6 |
5NDD,
5TZR,
4PHU,
5NJ6,
5NDZ,
5KW2
|
0.07 | — | 0 | 0.50 | — | — | — | 3 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x49 |
|
A | 2 | 2 | 6 |
5TZY,
5TZR,
4PHU,
4XES,
5KW2,
4GRV
|
0.01 | — | 0 | 0.50 | Pos & Mutant AA Match | — | — | 2 | — | 2 | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x58 |
|
F | 1 | 1 | 4 |
5KW2,
5TZY,
5TZR,
4PHU
|
0.01 | — | 0.54 | -1.71 | — | — | — | 4 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x37 |
|
C | 1 | 1 | 1 |
4Z36
|
— | — | 0.68 | -0.02 | — | — | — | 8 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x59 |
|
C | 1 | 1 | 1 |
4Z36
|
0.01 | — | 0.68 | -0.02 | — | — | — | 32 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM1 | 1x54 |
|
L | 1 | 1 | 22 |
6Z4Q,
6ZIN,
4BV0,
6Z66,
4BUO,
6Z8N,
6Z4V,
8FN0,
4XEE,
3ZEV,
4GRV,
8FMZ,
7L0S,
7L0P,
4XES,
6YVR,
4BWB,
7L0R,
5T04,
6Z4S,
6ZA8,
7L0Q
|
0.37 | — | 0.21 | -1.25 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
ECL2 | — |
|
A | 2 | 2 | 5 |
5T04,
4XES,
4XEE,
5X33,
4GRV
|
— | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x54 |
|
A | 1 | 1 | 4 |
4BUO,
3ZEV,
4BV0,
4BWB
|
0.01 | — | 0 | 0.50 | — | — | — | 4 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x43 |
|
A | 1 | 1 | 4 |
4XES,
4XEE,
5T04,
4GRV
|
0.19 | — | 0 | 0.50 | — | — | — | 2 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
N-term | — |
|
C | 2 | 1 | 19 |
5DGY,
5EN0,
6FKB,
4BEZ,
6FK7,
4BEY,
6FK8,
5W0P,
5DYS,
2X72,
6FKA,
6FKC,
6FK9,
2J4Y,
3C9M,
6FKD,
4A4M,
6FK6,
4ZWJ
|
— | — | 0.68 | -0.02 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x60 |
|
I | 1 | 1 | 2 |
5EN0,
5DYS
|
0.04 | 0.25 | 0.41 | -1.12 | — | — | — | 96 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x28 |
|
Q | 2 | 1 | 4 |
5DGY,
2X72,
5W0P,
4ZWJ
|
0.01 | — | 0.39 | 0.77 | — | — | — | 57 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x40 |
|
Y | 2 | 1 | 4 |
5DGY,
5W0P,
4ZWJ,
4A4M
|
0.01 | — | 0.53 | -0.71 | — | — | — | 2 | 1 | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x49 |
|
N | 2 | 1 | 6 |
4PXZ,
4XNW,
4XNV,
4NTJ,
4PY0,
7PP1
|
0.72 | — | 0.65 | 0.85 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM1 | 1x46 |
|
A | 1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.11 | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x37 |
|
A | 1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.05 | — | 0 | 0.50 | — | — | — | 3 | 1 | 1 | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x43 |
|
L | 1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.73 | — | 0.21 | -1.25 | — | — | — | 2 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x51 |
|
A | 1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.0 | — | 0 | 0.50 | — | — | — | 1 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x53 |
|
E | 1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.01 | — | 0.40 | 0.11 | — | — | — | — | — | 5 | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x64 |
|
A | 1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.12 | — | 0 | 0.50 | — | — | — | — | 1 | 3 | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x38 |
|
A | 1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.14 | — | 0 | 0.50 | — | — | — | 4 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x42 |
|
A | 1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.13 | — | 0 | 0.50 | — | — | — | 1 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x34 |
|
D | 1 | 1 | 2 |
5ZKQ,
5ZKP
|
— | — | 0.69 | 0.43 | — | — | — | 2 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x67 |
|
G | 1 | 1 | 1 |
5X33
|
0.27 | — | 1.00 | 1.15 | — | — | — | 15 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x21 |
|
G | 1 | 1 | 1 |
5X33
|
0.68 | — | 1.00 | 1.15 | — | — | — | 7 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x67 |
|
A | 1 | 1 | 1 |
5X33
|
0.09 | — | 0 | 0.50 | — | — | — | — | — | 1 | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM1 | 1x36 |
|
A | 1 | 1 | 5 |
8GTG,
4K5Y,
8GTM,
4Z9G,
8GTI
|
— | — | 0 | 0.50 | — | — | — | 13 | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM1 | 1x60 |
|
A | 1 | 1 | 5 |
8GTG,
4K5Y,
8GTM,
4Z9G,
8GTI
|
— | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM2 | 2x44 |
|
A | 1 | 1 | 2 |
4Z9G,
4K5Y
|
0.07 | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM2 | 2x48 |
|
A | 1 | 1 | 2 |
4Z9G,
4K5Y
|
0.2 | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM4 | 4x43 |
|
A | 1 | 1 | 2 |
4Z9G,
4K5Y
|
— | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
ECL2 | 45x52 |
|
A | 2 | 2 | 3 |
4Z9G,
4K5Y,
5NX2
|
— | — | 0 | 0.50 | — | — | — | 15 | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM5 | 5x48 |
|
A | 1 | 1 | 2 |
4Z9G,
4K5Y
|
— | — | 0 | 0.50 | — | — | — | 6 | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x30 |
|
A | 3 | 2 | 5 |
5VEX,
4K5Y,
5EE7,
5VEW,
4Z9G
|
— | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x51 |
|
A | 1 | 1 | 2 |
4Z9G,
4K5Y
|
— | — | 0 | 0.50 | — | — | — | 3 | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM7 | 7x38 |
|
A | 1 | 1 | 2 |
4Z9G,
4K5Y
|
— | — | 0 | 0.50 | — | — | — | 15 | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM7 | 7x53 |
|
A | 1 | 1 | 2 |
4Z9G,
4K5Y
|
— | — | 0 | 0.50 | — | — | Pos & Mutant AA Match | 1 | — | 1 | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM2 | 2x56 |
|
C | 1 | 1 | 2 |
5VEW,
5VEX
|
— | — | 0.68 | -0.02 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM2 | 2x59 |
|
F | 2 | 1 | 3 |
5EE7,
5VEW,
5VEX
|
— | — | 0.54 | -1.71 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
ECL1 | — |
|
E | 2 | 1 | 2 |
5EE7,
5NX2
|
— | — | 0.40 | 0.11 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
ECL1 | — |
|
A | 1 | 1 | 1 |
5NX2
|
— | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
ECL1 | — |
|
R | 1 | 1 | 1 |
5NX2
|
— | — | 0.21 | 1.81 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM3 | 3x24 |
|
A | 2 | 1 | 3 |
5EE7,
5VEW,
5VEX
|
0.07 | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM3 | 3x31 |
|
F | 1 | 1 | 1 |
5NX2
|
0.4 | — | 0.54 | -1.71 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM3 | 3x32 |
|
C | 1 | 1 | 2 |
5VEW,
5VEX
|
— | — | 0.68 | -0.02 | — | — | — | 12 | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
ICL2 | — |
|
F | 1 | 1 | 1 |
5NX2
|
— | — | 0.54 | -1.71 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM4 | 4x48 |
|
A | 1 | 1 | 2 |
5VEW,
5VEX
|
0.07 | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM5 | 5x51 |
|
C | 1 | 1 | 2 |
5VEW,
5VEX
|
— | — | 0.68 | -0.02 | — | — | — | 1 | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM5 | 5x52 |
|
I | 1 | 1 | 2 |
5VEW,
5VEX
|
0.07 | — | 0.41 | -1.12 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM5 | 5x63 |
|
A | 1 | 1 | 1 |
5NX2
|
— | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x31 |
|
F | 1 | 1 | 2 |
5VEW,
5VEX
|
0.07 | — | 0.54 | -1.71 | — | — | — | 1 | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x42 |
|
A | 1 | 1 | 1 |
5NX2
|
— | — | 0 | 0.50 | — | — | — | 2 | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x45 |
|
A | 1 | 1 | 1 |
5NX2
|
— | — | 0 | 0.50 | — | — | — | 1 | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x45 |
|
C | 1 | 1 | 2 |
5VEW,
5VEX
|
— | — | 0.68 | -0.02 | — | — | — | 1 | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x47 |
|
V | 1 | 1 | 1 |
5NX2
|
— | — | 0.61 | -0.46 | — | — | — | 2 | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM7 | 7x56 |
|
A | 1 | 1 | 1 |
5NX2
|
0.07 | — | 0 | 0.50 | — | — | — | 1 | — | 2 | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM1 | 1x48 |
|
A | 1 | 1 | 1 |
5EE7
|
0.33 | — | 0 | 0.50 | — | — | — | 2 | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM2 | 2x39 |
|
A | 1 | 1 | 2 |
5EE7,
5YQZ
|
— | — | 0 | 0.50 | — | — | — | 1 | — | 2 | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM2 | 2x48 |
|
L | 1 | 1 | 1 |
5EE7
|
0.2 | — | 0.21 | -1.25 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM2 | 2x56 |
|
A | 1 | 1 | 1 |
5EE7
|
0.27 | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM4 | 4x54 |
|
A | 1 | 1 | 1 |
5EE7
|
0.27 | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x48 |
|
F | 1 | 1 | 1 |
5EE7
|
0.13 | — | 0.54 | -1.71 | — | — | — | 6 | — | — | |||||||||||||||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM7 | 7x39 |
|
A | 1 | 1 | 1 |
5EE7
|
0.07 | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
C (Glutamate) |
|
|
|
|
TM1 | 1x35 |
|
A | 1 | 1 | 6 |
5CGD,
6FFH,
6FFI,
4OO9,
5CGC,
7P2L
|
0.05 | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
C (Glutamate) |
|
|
|
|
TM3 | 3x48 |
|
Y | 1 | 1 | 6 |
5CGD,
6FFH,
6FFI,
4OO9,
5CGC,
7P2L
|
0.05 | — | 0.53 | -0.71 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
C (Glutamate) |
|
|
|
|
TM3 | 3x50 |
|
A | 1 | 1 | 6 |
5CGD,
6FFH,
6FFI,
4OO9,
5CGC,
7P2L
|
0.05 | — | 0 | 0.50 | Pos & Mutant AA Match | — | — | — | — | — | |||||||||||||||||||||||||||||
|
C (Glutamate) |
|
|
|
|
ICL2 | — |
|
M | 1 | 1 | 6 |
5CGD,
6FFH,
6FFI,
4OO9,
5CGC,
7P2L
|
— | — | 0.24 | -0.67 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
C (Glutamate) |
|
|
|
|
TM5 | 5x42 |
|
A | 1 | 1 | 15 |
7FD9,
6FFH,
8X0D,
8X0G,
5CGC,
8X0E,
8X0F,
7FD8,
5CGD,
6FFI,
8X0B,
8X0H,
8X0C,
4OO9,
7P2L
|
0.05 | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
C (Glutamate) |
|
|
|
|
TM5 | 5x53 |
|
A | 1 | 1 | 15 |
7FD9,
6FFH,
8X0D,
8X0G,
5CGC,
8X0E,
8X0F,
7FD8,
5CGD,
6FFI,
8X0B,
8X0H,
8X0C,
4OO9,
7P2L
|
— | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||||||||||||||
|
F (Frizzled) |
|
|
|
|
TM3 | 3x40 |
|
F | 1 | 1 | 2 |
5L7D,
5L7I
|
— | — | 0.54 | -1.71 | — | — | — | 1 | — | — | |||||||||||||||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x39 |
|
A | 1 | 1 | 1 |
5WF6
|
0.03 | — | 0 | 0.50 | — | Pos & AA Mutant Match | — | 5 | — | — | |||||||||||||||||||||||||||||
| STATE | TARGETS | MUTATIONS | FREQUENCY | DATA (WILD TYPE) | SITES | INTERFACES | ||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| State | Class | Ligand Type | Receptor Family | UniProt | Receptor | Segment | Position (GN) | WT | Mut | No. GPCRS | No. Receptor Families | No. Structures | PDBs | Class Sequence Conservation | Receptor Family Sequence Conservation | Helix Propen- sity | Hydroph- obicity | Ionic Lock | Sodium Ion Binding Site | Switch | LigandBinding | Arrestin | G-PROTEIN | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x41 | L |
|
3 | 3 | 13 |
3ODU,
7C61,
9F34,
4IAR,
3OE8,
9F33,
4RWS,
3OE9,
3OE0,
5V54,
3PBL,
4IAQ,
3OE6
|
0.32 | — | 0.21 | -1.25 | — | — | — | 8 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x41 | M |
|
1 | 1 | 8 |
6DRX,
5TVN,
4NC3,
5TUD,
6DRZ,
6DRY,
4IB4,
6DS0
|
0.04 | — | 0.24 | -0.67 | — | — | — | 8 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x45 | C |
|
1 | 1 | 2 |
6BQH,
6BQG
|
0.01 | — | 0.68 | -0.02 | — | Pos & Wild Type AA Match | — | 5 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x52 | A |
|
2 | 1 | 28 |
5IUA,
5IU4,
5IUB,
2YDV,
5IU8,
5OLZ,
5MZP,
5N2S,
5NLX,
5OLO,
3RFM,
2YDO,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
4UG2,
5OM4,
5NM2,
5IU7,
5OM1,
4UHR,
5MZJ,
5N2R,
3UZA
|
0.06 | — | 0 | 0.50 | — | — | — | 2 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x36 | T |
|
2 | 1 | 24 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5N2S,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
0.05 | — | 0.66 | 0.25 | — | — | — | 116 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x63 | Y |
|
1 | 1 | 1 |
5N2S
|
0.03 | — | 0.53 | -0.71 | — | — | — | — | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x37 | L |
|
4 | 3 | 26 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5N2S,
5NLX,
5OLO,
3RFM,
4GRV,
6CM4,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
0.38 | — | 0.21 | -1.25 | — | — | — | 7 | 1 | 4 | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x41 | L |
|
2 | 2 | 2 |
5N2S,
6CM4
|
0.18 | — | 0.21 | -1.25 | — | — | — | 2 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x41 | T |
|
1 | 1 | 1 |
5N2S
|
0.07 | — | 0.66 | 0.25 | — | — | — | 63 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x46 | L |
|
1 | 1 | 4 |
4UHR,
2YDO,
4UG2,
2YDV
|
0.9 | — | 0.21 | -1.25 | — | — | — | — | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x50 | D |
|
1 | 1 | 1 |
5WF5
|
0.92 | — | 0.69 | 0.43 | — | Pos & Wild Type AA Match | — | 3 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x62 | T |
|
1 | 1 | 4 |
4UHR,
2YDO,
4UG2,
2YDV
|
0.1 | — | 0.66 | 0.25 | — | — | — | 6 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x37 | Q |
|
1 | 1 | 4 |
4UHR,
2YDO,
4UG2,
2YDV
|
0.02 | — | 0.39 | 0.77 | — | — | — | 68 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x55 | R |
|
1 | 1 | 23 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
0.04 | — | 0.21 | 1.81 | — | — | — | — | 1 | 2 | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM4 | 4x43 | K |
|
1 | 1 | 23 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
0.16 | — | 0.26 | 2.80 | — | — | — | 1 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x63 | L |
|
1 | 1 | 23 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
0.14 | — | 0.21 | -1.25 | — | — | — | — | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x41 | V |
|
1 | 1 | 23 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
0.41 | — | 0.61 | -0.46 | — | — | — | 2 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x41 | S |
|
1 | 1 | 23 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
0.16 | — | 0.50 | 0.46 | — | — | — | 63 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM1 | 1x59 | R |
|
1 | 1 | 24 |
4AMI,
2YCZ,
4AMJ,
4BVN,
5F8U,
3ZPR,
6H7J,
2Y00,
2YCY,
2YCW,
6H7O,
2Y03,
2YCX,
2Y04,
6H7N,
6H7L,
6H7M,
3ZPQ,
2Y01,
6IBL,
5A8E,
2Y02,
2VT4,
4GPO
|
0.24 | — | 0.21 | 1.81 | — | — | — | — | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x53 | M |
|
1 | 1 | 25 |
4AMI,
2YCZ,
4AMJ,
4BVN,
5F8U,
3ZPR,
6H7J,
2Y00,
2YCY,
2YCW,
6H7O,
6TKO,
2Y03,
2YCX,
2Y04,
6H7N,
6H7L,
6H7M,
3ZPQ,
2Y01,
6IBL,
5A8E,
2Y02,
2VT4,
4GPO
|
0.07 | 0.33 | 0.24 | -0.67 | — | — | — | 24 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x40 | I |
|
2 | 2 | 3 |
5A8E,
4BVN,
6CM4
|
0.4 | — | 0.41 | -1.12 | — | — | — | 20 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x41 | E |
|
2 | 1 | 5 |
3NY9,
3D4S,
5A8E,
3NY8,
3NYA
|
0.01 | 0.33 | 0.40 | 0.11 | — | — | — | 8 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x58 | Y |
|
2 | 2 | 22 |
5TZY,
4AMI,
2YCZ,
4AMJ,
4BVN,
5F8U,
3ZPR,
2Y00,
2YCY,
2YCW,
2Y03,
2YCX,
2Y04,
5TZR,
4PHU,
5KW2,
3ZPQ,
2Y01,
5A8E,
2Y02,
2VT4,
4GPO
|
0.74 | — | 0.53 | -0.71 | — | — | — | 4 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x27 | A |
|
1 | 1 | 18 |
2YCX,
4AMI,
2YCZ,
4AMJ,
4BVN,
3ZPQ,
2YCW,
3ZPR,
2Y01,
2Y00,
5F8U,
5A8E,
2Y02,
2YCY,
2VT4,
4GPO,
2Y03,
2Y04
|
0.08 | 0.11 | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x31 | D |
|
1 | 1 | 1 |
4BVN
|
0.1 | 0.22 | 0.69 | 0.43 | — | — | — | 67 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x36 | F |
|
1 | 1 | 25 |
4AMI,
2YCZ,
4AMJ,
4BVN,
5F8U,
3ZPR,
6H7J,
2Y00,
2YCY,
2YCW,
6H7O,
6TKO,
2Y03,
2YCX,
2Y04,
6H7N,
6H7L,
6H7M,
3ZPQ,
2Y01,
6IBL,
5A8E,
2Y02,
2VT4,
4GPO
|
0.14 | 0.44 | 0.54 | -1.71 | — | — | — | 3 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x48 | F |
|
1 | 1 | 25 |
4AMI,
2YCZ,
4AMJ,
4BVN,
5F8U,
3ZPR,
6H7J,
2Y00,
2YCY,
2YCW,
6H7O,
6TKO,
2Y03,
2YCX,
2Y04,
6H7N,
6H7L,
6H7M,
3ZPQ,
2Y01,
6IBL,
5A8E,
2Y02,
2VT4,
4GPO
|
0.06 | 0.33 | 0.54 | -1.71 | — | — | — | 1 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x53 | Y |
|
1 | 1 | 2 |
5A8E,
4BVN
|
0.89 | 1.0 | 0.53 | -0.71 | — | Pos & Wild Type AA Match | Pos & Wild Type AA Match | 8 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x63 | H |
|
1 | 1 | 2 |
4QKX,
3PDS
|
0.03 | 0.11 | 0.61 | 0.11 | — | — | — | 71 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x40 | V |
|
1 | 1 | 1 |
5VBL
|
0.24 | — | 0.61 | -0.46 | — | — | — | 20 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x48 | W |
|
1 | 1 | 1 |
5VBL
|
0.68 | — | 0.49 | -2.09 | — | Pos & Wild Type AA Match | — | 84 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM1 | 1x60 | C |
|
1 | 1 | 5 |
5UIW,
6AKX,
6AKY,
4MBS,
7F1T
|
0.02 | — | 0.68 | -0.02 | — | — | — | 1 | — | 2 | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM4 | 4x61 | G |
|
1 | 1 | 8 |
5UIW,
7F1Q,
6AKX,
6AKY,
7F1S,
4MBS,
7F1R,
7F1T
|
0.02 | — | 1.00 | 1.15 | — | — | — | 49 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x33 | A |
|
1 | 1 | 5 |
5UIW,
6AKX,
6AKY,
4MBS,
7F1T
|
0.28 | — | 0 | 0.50 | — | — | — | 4 | 1 | 6 | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
H8 | 8x49 | K |
|
1 | 1 | 5 |
5UIW,
6AKX,
6AKY,
4MBS,
7F1T
|
0.13 | — | 0.26 | 2.80 | — | — | — | 4 | 1 | 2 | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
ICL1 | 12x48 | T |
|
1 | 1 | 1 |
5LWE
|
0.05 | — | 0.66 | 0.25 | — | — | — | — | — | 4 | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
ICL1 | 12x50 | V |
|
1 | 1 | 1 |
5LWE
|
0.03 | — | 0.61 | -0.46 | — | — | — | 2 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x38 | M |
|
1 | 1 | 1 |
5LWE
|
0.04 | — | 0.24 | -0.67 | — | — | — | — | 1 | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x47 | S |
|
1 | 1 | 1 |
5LWE
|
0.55 | — | 0.50 | 0.46 | — | — | — | 1 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x41 | T |
|
1 | 1 | 1 |
5LWE
|
0.09 | — | 0.66 | 0.25 | — | — | — | 3 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x36 | V |
|
1 | 1 | 1 |
5LWE
|
0.15 | — | 0.61 | -0.46 | — | — | — | 6 | 1 | 5 | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x29 | N |
|
1 | 1 | 1 |
5LWE
|
0.03 | — | 0.65 | 0.85 | — | — | — | 2 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x39 | T |
|
1 | 1 | 1 |
5LWE
|
0.03 | — | 0.66 | 0.25 | — | — | — | 20 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x46 | T |
|
1 | 1 | 4 |
5XR8,
5XRA,
5TGZ,
5U09
|
0.01 | — | 0.66 | 0.25 | — | — | — | 1 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x37 | E |
|
1 | 1 | 3 |
5XRA,
5TGZ,
5XR8
|
0.04 | — | 0.40 | 0.11 | — | — | — | 8 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x32 | R |
|
1 | 1 | 3 |
5XRA,
5TGZ,
5XR8
|
0.32 | — | 0.21 | 1.81 | — | — | — | — | 1 | 5 | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
ECL2 | 45x51 | D |
|
1 | 1 | 1 |
4RWS
|
0.03 | — | 0.69 | 0.43 | — | — | — | 111 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x36 | T |
|
1 | 1 | 3 |
3OE0,
4RWS,
3OE9
|
0.25 | — | 0.66 | 0.25 | — | — | — | 6 | 1 | 5 | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM1 | 1x55 | R |
|
1 | 1 | 2 |
5X93,
5XPR
|
0.02 | — | 0.21 | 1.81 | — | — | — | — | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x56 | D |
|
1 | 1 | 1 |
5X93
|
0.01 | — | 0.69 | 0.43 | — | — | — | 22 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x36 | K |
|
1 | 1 | 2 |
5X93,
5XPR
|
0.05 | — | 0.26 | 2.80 | — | — | — | 49 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x54 | S |
|
1 | 1 | 2 |
5X93,
5XPR
|
0.05 | — | 0.50 | 0.46 | — | — | — | 31 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x48 | I |
|
1 | 1 | 2 |
5X93,
5XPR
|
0.15 | — | 0.41 | -1.12 | — | — | — | 1 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x40 | L |
|
1 | 1 | 4 |
5KW2,
5TZY,
5TZR,
4PHU
|
0.03 | — | 0.21 | -1.25 | — | — | — | 4 | 1 | 1 | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x34 | F |
|
1 | 1 | 3 |
5KW2,
5TZR,
4PHU
|
0.11 | — | 0.54 | -1.71 | — | — | — | 3 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x49 | G |
|
1 | 1 | 4 |
5KW2,
5TZY,
5TZR,
4PHU
|
0.01 | — | 1.00 | 1.15 | Pos & Wild Type AA Match | — | — | 2 | — | 2 | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x37 | D |
|
1 | 1 | 1 |
4Z36
|
0.01 | — | 0.69 | 0.43 | — | — | — | 8 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x59 | V |
|
1 | 1 | 1 |
4Z36
|
0.12 | — | 0.61 | -0.46 | — | — | — | 32 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x41 | F |
|
1 | 1 | 2 |
5ZBQ,
5ZBH
|
0.28 | — | 0.54 | -1.71 | — | — | — | 8 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM1 | 1x54 | A |
|
1 | 1 | 22 |
6Z4Q,
6ZIN,
4BV0,
6Z66,
4BUO,
6Z8N,
6Z4V,
8FN0,
4XEE,
3ZEV,
4GRV,
8FMZ,
7L0S,
7L0P,
4XES,
6YVR,
4BWB,
7L0R,
5T04,
6Z4S,
6ZA8,
7L0Q
|
0.04 | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x49 | E |
|
1 | 1 | 2 |
4XES,
4GRV
|
0.21 | — | 0.40 | 0.11 | Pos & Wild Type AA Match | — | — | 2 | — | 2 | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
ECL2 | — | G |
|
1 | 1 | 4 |
4XES,
4XEE,
5T04,
4GRV
|
— | — | 1.00 | 1.15 | — | — | — | — | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x54 | I |
|
1 | 1 | 4 |
4BUO,
3ZEV,
4BV0,
4BWB
|
0.33 | — | 0.41 | -1.12 | — | — | — | 4 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x43 | V |
|
1 | 1 | 4 |
4XES,
4XEE,
5T04,
4GRV
|
0.1 | — | 0.61 | -0.46 | — | — | — | 2 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
N-term | — | N |
|
2 | 1 | 19 |
5DGY,
5EN0,
6FKB,
4BEZ,
6FK7,
4BEY,
6FK8,
5W0P,
5DYS,
2X72,
6FKA,
6FKC,
6FK9,
2J4Y,
3C9M,
6FKD,
4A4M,
6FK6,
4ZWJ
|
— | — | 0.65 | 0.85 | — | — | — | — | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x60 | T |
|
1 | 1 | 2 |
5EN0,
5DYS
|
0.08 | 0.38 | 0.66 | 0.25 | — | — | — | 96 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x28 | E |
|
2 | 1 | 4 |
5DGY,
2X72,
5W0P,
4ZWJ
|
0.02 | 0.5 | 0.40 | 0.11 | — | — | — | 57 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x40 | M |
|
2 | 1 | 4 |
5DGY,
5W0P,
4ZWJ,
4A4M
|
0.05 | 0.75 | 0.24 | -0.67 | — | — | — | 2 | 1 | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
ECL3 | — | D |
|
1 | 1 | 16 |
5EN0,
6FKB,
4BEZ,
6FK7,
4BEY,
6FK8,
5DYS,
2X72,
6FKA,
6FKC,
6FK9,
2J4Y,
3C9M,
6FKD,
4A4M,
6FK6
|
— | — | 0.69 | 0.43 | — | — | — | — | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM7 | 7x49 | D |
|
2 | 1 | 6 |
4PXZ,
4XNW,
4XNV,
4NTJ,
4PY0,
7PP1
|
0.2 | — | 0.69 | 0.43 | — | — | — | — | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM1 | 1x46 | G |
|
1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.54 | — | 1.00 | 1.15 | — | — | — | — | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x37 | H |
|
1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.03 | — | 0.61 | 0.11 | — | — | — | 3 | 1 | 1 | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x34 | G |
|
1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.02 | — | 1.00 | 1.15 | — | — | — | 3 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x43 | M |
|
1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.05 | — | 0.24 | -0.67 | — | — | — | 2 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x51 | Y |
|
1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.66 | — | 0.53 | -0.71 | — | — | — | 1 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x53 | V |
|
1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.07 | — | 0.61 | -0.46 | — | — | — | — | — | 5 | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x64 | M |
|
1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.01 | — | 0.24 | -0.67 | — | — | — | — | 1 | 3 | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x38 | I |
|
1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.08 | — | 0.41 | -1.12 | — | — | — | 4 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x42 | L |
|
1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.25 | — | 0.21 | -1.25 | — | — | — | 1 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM6 | 6x34 | A |
|
1 | 1 | 2 |
5ZKQ,
5ZKP
|
0.24 | — | 0 | 0.50 | — | — | — | 2 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM2 | 2x67 | H |
|
1 | 1 | 1 |
5X33
|
0.07 | — | 0.61 | 0.11 | — | — | — | 15 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x21 | K |
|
1 | 1 | 1 |
5X33
|
0.01 | — | 0.26 | 2.80 | — | — | — | 7 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM5 | 5x67 | V |
|
1 | 1 | 1 |
5X33
|
0.03 | — | 0.61 | -0.46 | — | — | — | — | — | 1 | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
C-term | — | S |
|
1 | 1 | 1 |
5X33
|
— | — | 0.50 | 0.46 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM1 | 1x36 | V |
|
1 | 1 | 5 |
8GTG,
4K5Y,
8GTM,
4Z9G,
8GTI
|
0.07 | — | 0.61 | -0.46 | — | — | — | 13 | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM1 | 1x60 | L |
|
1 | 1 | 5 |
8GTG,
4K5Y,
8GTM,
4Z9G,
8GTI
|
0.33 | — | 0.21 | -1.25 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM2 | 2x44 | W |
|
1 | 1 | 2 |
4Z9G,
4K5Y
|
0.13 | — | 0.49 | -2.09 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM2 | 2x48 | S |
|
1 | 1 | 2 |
4Z9G,
4K5Y
|
0.07 | — | 0.50 | 0.46 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM4 | 4x43 | K |
|
1 | 1 | 2 |
4Z9G,
4K5Y
|
0.13 | — | 0.26 | 2.80 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
ECL2 | 45x52 | F |
|
1 | 1 | 2 |
4Z9G,
4K5Y
|
0.13 | — | 0.54 | -1.71 | — | — | — | 15 | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM5 | 5x48 | I |
|
1 | 1 | 2 |
4Z9G,
4K5Y
|
0.2 | — | 0.41 | -1.12 | — | — | — | 6 | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x30 | Y |
|
1 | 1 | 2 |
4Z9G,
4K5Y
|
0.73 | — | 0.53 | -0.71 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x51 | F |
|
1 | 1 | 2 |
4Z9G,
4K5Y
|
0.93 | — | 0.54 | -1.71 | — | — | — | 3 | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM7 | 7x38 | S |
|
1 | 1 | 2 |
4Z9G,
4K5Y
|
0.13 | — | 0.50 | 0.46 | — | — | — | 15 | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM7 | 7x53 | Y |
|
1 | 1 | 2 |
4Z9G,
4K5Y
|
0.93 | — | 0.53 | -0.71 | — | — | Pos & Wild Type AA Match | 1 | — | 1 | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM2 | 2x56 | S |
|
2 | 1 | 3 |
5EE7,
5VEW,
5VEX
|
0.47 | — | 0.50 | 0.46 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM2 | 2x59 | I |
|
1 | 1 | 2 |
5VEW,
5VEX
|
0.4 | — | 0.41 | -1.12 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
ECL1 | — | T |
|
1 | 1 | 1 |
5NX2
|
— | — | 0.66 | 0.25 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
ECL1 | — | Q |
|
1 | 1 | 1 |
5NX2
|
— | — | 0.39 | 0.77 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
ECL1 | — | D |
|
1 | 1 | 1 |
5NX2
|
— | — | 0.69 | 0.43 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM3 | 3x24 | S |
|
1 | 1 | 2 |
5VEW,
5VEX
|
0.27 | — | 0.50 | 0.46 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM3 | 3x31 | L |
|
1 | 1 | 1 |
5NX2
|
0.2 | — | 0.21 | -1.25 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM3 | 3x32 | M |
|
1 | 1 | 2 |
5VEW,
5VEX
|
0.13 | — | 0.24 | -0.67 | — | — | — | 12 | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
ICL2 | — | L |
|
1 | 1 | 1 |
5NX2
|
— | — | 0.21 | -1.25 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM4 | 4x48 | S |
|
1 | 1 | 2 |
5VEW,
5VEX
|
0.07 | — | 0.50 | 0.46 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
ECL2 | — | G |
|
2 | 1 | 2 |
5EE7,
5NX2
|
— | — | 1.00 | 1.15 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
ECL2 | 45x52 | T |
|
1 | 1 | 1 |
5NX2
|
0.2 | — | 0.66 | 0.25 | — | — | — | 15 | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM5 | 5x51 | I |
|
1 | 1 | 2 |
5VEW,
5VEX
|
0.6 | — | 0.41 | -1.12 | — | — | — | 1 | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM5 | 5x52 | G |
|
1 | 1 | 2 |
5VEW,
5VEX
|
0.2 | — | 1.00 | 1.15 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM5 | 5x63 | C |
|
1 | 1 | 1 |
5NX2
|
0.07 | — | 0.68 | -0.02 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x30 | K |
|
2 | 1 | 3 |
5EE7,
5VEW,
5VEX
|
0.2 | — | 0.26 | 2.80 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x31 | C |
|
1 | 1 | 2 |
5VEW,
5VEX
|
0.07 | — | 0.68 | -0.02 | — | — | — | 1 | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x42 | P |
|
1 | 1 | 1 |
5NX2
|
0.93 | — | 3.16 | 0.14 | — | — | — | 2 | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x45 | G |
|
1 | 1 | 3 |
5VEW,
5VEX,
5NX2
|
1.0 | — | 1.00 | 1.15 | — | — | — | 1 | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x47 | H |
|
1 | 1 | 1 |
5NX2
|
0.73 | — | 0.61 | 0.11 | — | — | — | 2 | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM7 | 7x56 | V |
|
1 | 1 | 1 |
5NX2
|
0.07 | — | 0.61 | -0.46 | — | — | — | 1 | — | 2 | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM1 | 1x48 | G |
|
1 | 1 | 1 |
5EE7
|
0.13 | — | 1.00 | 1.15 | — | — | — | 2 | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM2 | 2x39 | R |
|
1 | 1 | 2 |
5EE7,
5YQZ
|
1.0 | — | 0.21 | 1.81 | — | — | — | 1 | — | 2 | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM2 | 2x48 | A |
|
1 | 1 | 1 |
5EE7
|
0.2 | — | 0 | 0.50 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM2 | 2x59 | V |
|
1 | 1 | 1 |
5EE7
|
0.4 | — | 0.61 | -0.46 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM3 | 3x24 | G |
|
1 | 1 | 1 |
5EE7
|
0.4 | — | 1.00 | 1.15 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM4 | 4x54 | M |
|
1 | 1 | 1 |
5EE7
|
0.07 | — | 0.24 | -0.67 | — | — | — | — | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM6 | 6x48 | E |
|
1 | 1 | 1 |
5EE7
|
0.27 | — | 0.40 | 0.11 | — | — | — | 6 | — | — | |||||||||||||||||
|
B1 (Secretin) |
|
|
|
|
TM7 | 7x39 | F |
|
1 | 1 | 1 |
5EE7
|
0.33 | — | 0.54 | -1.71 | — | — | — | — | — | — | |||||||||||||||||
|
C (Glutamate) |
|
|
|
|
TM1 | 1x35 | E |
|
1 | 1 | 6 |
5CGD,
6FFH,
6FFI,
4OO9,
5CGC,
7P2L
|
0.09 | — | 0.40 | 0.11 | — | — | — | — | — | — | |||||||||||||||||
|
C (Glutamate) |
|
|
|
|
TM3 | 3x48 | N |
|
1 | 1 | 6 |
5CGD,
6FFH,
6FFI,
4OO9,
5CGC,
7P2L
|
0.41 | — | 0.65 | 0.85 | — | — | — | — | — | — | |||||||||||||||||
|
C (Glutamate) |
|
|
|
|
TM3 | 3x50 | I |
|
1 | 1 | 6 |
5CGD,
6FFH,
6FFI,
4OO9,
5CGC,
7P2L
|
0.45 | — | 0.41 | -1.12 | Pos & Wild Type AA Match | — | — | — | — | — | |||||||||||||||||
|
C (Glutamate) |
|
|
|
|
ICL2 | — | G |
|
1 | 1 | 6 |
5CGD,
6FFH,
6FFI,
4OO9,
5CGC,
7P2L
|
— | — | 1.00 | 1.15 | — | — | — | — | — | — | |||||||||||||||||
|
C (Glutamate) |
|
|
|
|
TM5 | 5x42 | T |
|
1 | 1 | 15 |
7FD9,
6FFH,
8X0D,
8X0G,
5CGC,
8X0E,
8X0F,
7FD8,
5CGD,
6FFI,
8X0B,
8X0H,
8X0C,
4OO9,
7P2L
|
0.09 | — | 0.66 | 0.25 | — | — | — | — | — | — | |||||||||||||||||
|
C (Glutamate) |
|
|
|
|
TM5 | 5x53 | S |
|
1 | 1 | 15 |
7FD9,
6FFH,
8X0D,
8X0G,
5CGC,
8X0E,
8X0F,
7FD8,
5CGD,
6FFI,
8X0B,
8X0H,
8X0C,
4OO9,
7P2L
|
0.14 | — | 0.50 | 0.46 | — | — | — | — | — | — | |||||||||||||||||
|
F (Frizzled) |
|
|
|
|
TM3 | 3x40 | V |
|
1 | 1 | 2 |
5L7D,
5L7I
|
0.09 | 0.09 | 0.61 | -0.46 | — | — | — | 1 | — | — | |||||||||||||||||
|
A (Rhodopsin) |
|
|
|
|
TM3 | 3x39 | S |
|
1 | 1 | 1 |
5WF6
|
0.72 | — | 0.50 | 0.46 | — | Pos & Wild Type AA Match | — | 5 | — | — | |||||||||||||||||
| STATE | TARGETS | MUTATIONS | FREQUENCY | DATA (FOLD CHANGE (MUTANT/WILD TYPE)) | SITES | INTERFACES | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| State | Class | Ligand Type | Receptor Family | UniProt | Receptor | Segment | Position (GN) | WT | Mut | No. GPCRS | No. Receptor Families | No. Structures | PDBs | Class Sequence Conservation | Receptor Family Sequence Conservation | Helix Propen- sity | Hydroph- obicity | Ionic Lock | Sodium Ion Binding Site | Switch | LigandBinding | Arrestin | G-PROTEIN | |||
|
A (Rhodopsin) | Aminergic Protein | Dopamine Chemokine 5-Hydroxytryptamine | DRD3 CXCR4 5HT1B | CXCR4 5-HT1B D3 | TM3 | 3x41 | L | W | 3 | 3 | 13 |
3ODU,
7C61,
9F34,
4IAR,
3OE8,
9F33,
4RWS,
3OE9,
3OE0,
5V54,
3PBL,
4IAQ,
3OE6
|
-0.29 (0.03−0.32) | — | 0.28 (0.49−0.21) | -0.84 (-2.09−-1.25) | — | — | — | 8 | — | — | |||
|
A (Rhodopsin) | Aminergic | 5-Hydroxytryptamine | 5HT2B | 5-HT2B | TM3 | 3x41 | M | W | 1 | 1 | 8 |
6DRX,
5TVN,
4NC3,
5TUD,
6DRZ,
6DRY,
4IB4,
6DS0
|
-0.01 (0.03−0.04) | 0 (0−0) | 0.25 (0.49−0.24) | -1.42 (-2.09−-0.67) | — | — | — | 8 | — | — | |||
|
A (Rhodopsin) | Aminergic | 5-Hydroxytryptamine | 5HT2C | 5-HT2C | TM7 | 7x45 | C | N | 1 | 1 | 2 |
6BQH,
6BQG
|
0.66 (0.67−0.01) | 0 (0−0) | -0.03 (0.65−0.68) | 0.87 (0.85−-0.02) | — | Added | — | 5 | — | — | |||
|
A (Rhodopsin) | Nucleotide | Adenosine | AA1R AA2AR | A1 A2A | TM2 | 2x52 | A | L | 2 | 1 | 28 |
5IUA,
5IU4,
5IUB,
2YDV,
5IU8,
5OLZ,
5MZP,
5N2S,
5NLX,
5OLO,
3RFM,
2YDO,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
4UG2,
5OM4,
5NM2,
5IU7,
5OM1,
4UHR,
5MZJ,
5N2R,
3UZA
|
0.57 (0.63−0.06) | 0 (0−0) | 0.21 (0.21−0) | -1.75 (-1.25−0.50) | — | — | — | 2 | — | — | |||
|
A (Rhodopsin) | Nucleotide | Adenosine | AA1R AA2AR | A1 A2A | TM3 | 3x36 | T | A | 2 | 1 | 24 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5N2S,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
-0.03 (0.02−0.05) | 0 (0−0) | -0.66 (0−0.66) | 0.25 (0.50−0.25) | — | — | — | 116 | — | — | |||
|
A (Rhodopsin) | Nucleotide | Adenosine | AA1R | A1 | TM5 | 5x63 | Y | A | 1 | 1 | 1 |
5N2S
|
0.02 (0.05−0.03) | 0 (0−0) | -0.53 (0−0.53) | 1.21 (0.50−-0.71) | — | — | — | — | — | — | |||
|
A (Rhodopsin) | Aminergic Nucleotide Peptide | Dopamine Neurotensin Adenosine | DRD2 AA1R AA2AR NTR1 | A1 A2A D2 NTS1 | TM6 | 6x37 | L | A | 4 | 3 | 26 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5N2S,
5NLX,
5OLO,
3RFM,
4GRV,
6CM4,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
-0.34 (0.04−0.38) | — | -0.21 (0−0.21) | 1.75 (0.50−-1.25) | — | — | — | 7 | 1 | 4 | |||
|
A (Rhodopsin) | Aminergic Nucleotide | Dopamine Adenosine | DRD2 AA1R | A1 D2 | TM6 | 6x41 | L | A | 2 | 2 | 2 |
5N2S,
6CM4
|
-0.13 (0.05−0.18) | — | -0.21 (0−0.21) | 1.75 (0.50−-1.25) | — | — | — | 2 | — | — | |||
|
A (Rhodopsin) | Nucleotide | Adenosine | AA1R | A1 | TM7 | 7x41 | T | A | 1 | 1 | 1 |
5N2S
|
0.31 (0.38−0.07) | 0 (0−0) | -0.66 (0−0.66) | 0.25 (0.50−0.25) | — | — | — | 63 | — | — | |||
|
A (Rhodopsin) | Nucleotide | Adenosine | AA2AR | A2A | TM2 | 2x46 | L | A | 1 | 1 | 4 |
4UHR,
2YDO,
4UG2,
2YDV
|
-0.9 (0−0.9) | 0 (0−0) | -0.21 (0−0.21) | 1.75 (0.50−-1.25) | — | — | — | — | — | — | |||
|
A (Rhodopsin) | Nucleotide | Adenosine | AA2AR | A2A | TM2 | 2x50 | D | N | 1 | 1 | 1 |
5WF5
|
-0.89 (0.03−0.92) | 0 (0−0) | -0.04 (0.65−0.69) | 0.42 (0.85−0.43) | — | Removed | — | 3 | — | — | |||
|
A (Rhodopsin) | Nucleotide | Adenosine | AA2AR | A2A | TM2 | 2x62 | T | A | 1 | 1 | 4 |
4UHR,
2YDO,
4UG2,
2YDV
|
0.02 (0.12−0.1) | 0 (0−0) | -0.66 (0−0.66) | 0.25 (0.50−0.25) | — | — | — | 6 | — | — | |||
|
A (Rhodopsin) | Nucleotide | Adenosine | AA2AR | A2A | TM3 | 3x37 | Q | A | 1 | 1 | 4 |
4UHR,
2YDO,
4UG2,
2YDV
|
0.01 (0.03−0.02) | 0 (0−0) | -0.39 (0−0.39) | -0.27 (0.50−0.77) | — | — | — | 68 | — | — | |||
|
A (Rhodopsin) | Nucleotide | Adenosine | AA2AR | A2A | TM3 | 3x55 | R | A | 1 | 1 | 23 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
0.04 (0.08−0.04) | 0 (0−0) | -0.21 (0−0.21) | -1.31 (0.50−1.81) | — | — | — | — | 1 | 2 | |||
|
A (Rhodopsin) | Nucleotide | Adenosine | AA2AR | A2A | TM4 | 4x43 | K | A | 1 | 1 | 23 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
-0.03 (0.13−0.16) | 0 (0−0) | -0.26 (0−0.26) | -2.30 (0.50−2.80) | — | — | — | 1 | — | — | |||
|
A (Rhodopsin) | Nucleotide | Adenosine | AA2AR | A2A | TM5 | 5x63 | L | A | 1 | 1 | 23 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
-0.09 (0.05−0.14) | 0 (0−0) | -0.21 (0−0.21) | 1.75 (0.50−-1.25) | — | — | — | — | — | — | |||
|
A (Rhodopsin) | Nucleotide | Adenosine | AA2AR | A2A | TM6 | 6x41 | V | A | 1 | 1 | 23 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
-0.36 (0.05−0.41) | 0 (0−0) | -0.61 (0−0.61) | 0.96 (0.50−-0.46) | — | — | — | 2 | — | — | |||
|
A (Rhodopsin) | Nucleotide | Adenosine | AA2AR | A2A | TM7 | 7x41 | S | A | 1 | 1 | 23 |
5IUA,
5IU4,
5IUB,
5IU8,
5OLZ,
5MZP,
5NLX,
5OLO,
3RFM,
5OLV,
5NM4,
5OLG,
5OLH,
3PWH,
3UZC,
3REY,
5OM4,
5NM2,
5IU7,
5OM1,
5MZJ,
5N2R,
3UZA
|
0.22 (0.38−0.16) | 0 (0−0) | -0.50 (0−0.50) | 0.04 (0.50−0.46) | — | — | — | 63 | — | — | |||
|
A (Rhodopsin) | Aminergic | Adrenoceptors | ADRB1 | β1 | TM1 | 1x59 | R | S | 1 | 1 | 24 |
4AMI,
2YCZ,
4AMJ,
4BVN,
5F8U,
3ZPR,
6H7J,
2Y00,
2YCY,
2YCW,
6H7O,
2Y03,
2YCX,
2Y04,
6H7N,
6H7L,
6H7M,
3ZPQ,
2Y01,
6IBL,
5A8E,
2Y02,
2VT4,
4GPO
|
-0.2 (0.04−0.24) | 0 (0−0) | 0.29 (0.50−0.21) | -1.35 (0.46−1.81) | — | — | — | — | — | — | |||
|
A (Rhodopsin) | Aminergic | Adrenoceptors | ADRB1 | β1 | TM2 | 2x53 | M | V | 1 | 1 | 25 |
4AMI,
2YCZ,
4AMJ,
4BVN,
5F8U,
3ZPR,
6H7J,
2Y00,
2YCY,
2YCW,
6H7O,
6TKO,
2Y03,
2YCX,
2Y04,
6H7N,
6H7L,
6H7M,
3ZPQ,
2Y01,
6IBL,
5A8E,
2Y02,
2VT4,
4GPO
|
0.16 (0.23−0.07) | 0.0 (0.33−0.33) | 0.37 (0.61−0.24) | 0.21 (-0.46−-0.67) | — | — | — | 24 | — | — | |||
|
A (Rhodopsin) | Aminergic | Adrenoceptors | ADRB1 | β1 | TM3 | 3x40 | I | V | 1 | 1 | 2 |
5A8E,
4BVN
|
-0.16 (0.24−0.4) | -1.0 (0−1.0) | 0.20 (0.61−0.41) | 0.66 (-0.46−-1.12) | — | — | — | 20 | — | — | |||
|
A (Rhodopsin) | Aminergic | Adrenoceptors | ADRB1 ADRB2 | β2 β1 | TM3 | 3x41 | E | W | 2 | 1 | 5 |
3NY9,
3D4S,
5A8E,
3NY8,
3NYA
|
0.02 (0.03−0.01) | -0.33 (0−0.33) | 0.09 (0.49−0.40) | -2.20 (-2.09−0.11) | — | — | — | 8 | — | — | |||
|
A (Rhodopsin) | Aminergic | Adrenoceptors | ADRB1 | β1 | TM5 | 5x58 | Y | A | 1 | 1 | 18 |
2YCX,
4AMI,
2YCZ,
4AMJ,
4BVN,
3ZPQ,
2YCW,
3ZPR,
2Y01,
2Y00,
5F8U,
5A8E,
2Y02,
2YCY,
2VT4,
4GPO,
2Y03,
2Y04
|
-0.72 (0.02−0.74) | -1.0 (0−1.0) | -0.53 (0−0.53) | 1.21 (0.50−-0.71) | — | — | — | 4 | — | — | |||
|
A (Rhodopsin) | Aminergic | Adrenoceptors | ADRB1 | β1 | TM6 | 6x27 | A | L | 1 | 1 | 18 |
2YCX,
4AMI,
2YCZ,
4AMJ,
4BVN,
3ZPQ,
2YCW,
3ZPR,
2Y01,
2Y00,
5F8U,
5A8E,
2Y02,
2YCY,
2VT4,
4GPO,
2Y03,
2Y04
|
0.04 (0.12−0.08) | 0.0 (0.11−0.11) | 0.21 (0.21−0) | -1.75 (-1.25−0.50) | — | — | — | — | — | — | |||
|
A (Rhodopsin) | Aminergic | Adrenoceptors | ADRB1 | β1 | TM7 | 7x31 | D | K | 1 | 1 | 1 |
4BVN
|
-0.06 (0.04−0.1) | -0.11 (0.11−0.22) | -0.43 (0.26−0.69) | 2.37 (2.80−0.43) | — | — | — | 67 | — | — | |||
|
A (Rhodopsin) | Aminergic | Adrenoceptors | ADRB1 | β1 | TM7 | 7x36 | F | A | 1 | 1 | 25 |
4AMI,
2YCZ,
4AMJ,
4BVN,
5F8U,
3ZPR,
6H7J,
2Y00,
2YCY,
2YCW,
6H7O,
6TKO,
2Y03,
2YCX,
2Y04,
6H7N,
6H7L,
6H7M,
3ZPQ,
2Y01,
6IBL,
5A8E,
2Y02,
2VT4,
4GPO
|
-0.04 (0.1−0.14) | -0.33 (0.11−0.44) | -0.54 (0−0.54) | 2.21 (0.50−-1.71) | — | — | — | 3 | — | — | |||
|
A (Rhodopsin) | Aminergic | Adrenoceptors | ADRB1 | β1 | TM7 | 7x48 | F | M | 1 | 1 | 25 |
4AMI,
2YCZ,
4AMJ,
4BVN,
5F8U,
3ZPR,
6H7J,
2Y00,
2YCY,
2YCW,
6H7O,
6TKO,
2Y03,
2YCX,
2Y04,
6H7N,
6H7L,
6H7M,
3ZPQ,
2Y01,
6IBL,
5A8E,
2Y02,
2VT4,
4GPO
|
-0.01 (0.05−0.06) | -0.33 (0−0.33) | -0.30 (0.24−0.54) | 1.04 (-0.67−-1.71) | — | — | — | 1 | — | — | |||
|
A (Rhodopsin) | Aminergic | Adrenoceptors | ADRB1 | β1 | TM7 | 7x53 | Y | L | 1 | 1 | 2 |
5A8E,
4BVN
|
-0.86 (0.03−0.89) | -1.0 (0−1.0) | -0.32 (0.21−0.53) | -0.54 (-1.25−-0.71) | — | — | Removed | 8 | — | — | |||
|
A (Rhodopsin) | Aminergic | Adrenoceptors | ADRB2 | β2 | TM2 | 2x63 | H | C | 1 | 1 | 2 |
4QKX,
3PDS
|
-0.03 (0−0.03) | -0.11 (0−0.11) | 0.07 (0.68−0.61) | -0.13 (-0.02−0.11) | — | — | — | 71 | — | — | |||
|
A (Rhodopsin) | Peptide | Apelin | APJ | apelin | TM3 | 3x40 | V | A | 1 | 1 | 1 |
5VBL
|
-0.18 (0.06−0.24) | 0 (0−0) | -0.61 (0−0.61) | 0.96 (0.50−-0.46) | — | — | — | 20 | — | — | |||
|
A (Rhodopsin) | Peptide | Apelin | APJ | apelin | TM6 | 6x48 | W | K | 1 | 1 | 1 |
5VBL
|
-0.68 (0−0.68) | 0 (0−0) | -0.23 (0.26−0.49) | 4.89 (2.80−-2.09) | — | — | — | 84 | — | — | |||
|
A (Rhodopsin) | Protein | Chemokine | CCR5 | CCR5 | TM1 | 1x60 | C | Y | 1 | 1 | 5 |
5UIW,
6AKX,
6AKY,
4MBS,
7F1T
|
0.06 (0.08−0.02) | 0 (0−0) | -0.15 (0.53−0.68) | -0.69 (-0.71−-0.02) | — | — | — | 1 | — | 2 | |||
|
A (Rhodopsin) | Protein | Chemokine | CCR5 | CCR5 | TM4 | 4x61 | G | N | 1 | 1 | 8 |
5UIW,
7F1Q,
6AKX,
6AKY,
7F1S,
4MBS,
7F1R,
7F1T
|
0.02 (0.04−0.02) | 0 (0−0) | -0.35 (0.65−1.00) | -0.30 (0.85−1.15) | — | — | — | 49 | — | — | |||
|
A (Rhodopsin) | Protein | Chemokine | CCR5 | CCR5 | TM6 | 6x33 | A | D | 1 | 1 | 5 |
5UIW,
6AKX,
6AKY,
4MBS,
7F1T
|
-0.28 (0−0.28) | 0 (0−0) | 0.69 (0.69−0) | -0.07 (0.43−0.50) | — | — | — | 4 | 1 | 6 | |||
|
A (Rhodopsin) | Protein | Chemokine | CCR5 | CCR5 | H8 | 8x49 | K | E | 1 | 1 | 5 |
5UIW,
6AKX,
6AKY,
4MBS,
7F1T
|
-0.01 (0.12−0.13) | 0 (0−0) | 0.14 (0.40−0.26) | -2.69 (0.11−2.80) | — | — | — | 4 | 1 | 2 | |||
|
A (Rhodopsin) | Protein | Chemokine | CCR9 | CCR9 | ICL1 | 12x48 | T | A | 1 | 1 | 1 |
5LWE
|
-0.01 (0.04−0.05) | 0 (0−0) | -0.66 (0−0.66) | 0.25 (0.50−0.25) | — | — | — | — | — | 4 | |||
|
A (Rhodopsin) | Protein | Chemokine | CCR9 | CCR9 | ICL1 | 12x50 | V | A | 1 | 1 | 1 |
5LWE
|
0.04 (0.07−0.03) | 0 (0−0) | -0.61 (0−0.61) | 0.96 (0.50−-0.46) | — | — | — | 2 | — | — | |||
|
A (Rhodopsin) | Protein | Chemokine | CCR9 | CCR9 | TM2 | 2x38 | M | A | 1 | 1 | 1 |
5LWE
|
0.08 (0.12−0.04) | 0 (0−0) | -0.24 (0−0.24) | 1.17 (0.50−-0.67) | — | — | — | — | 1 | — | |||
|
A (Rhodopsin) | Protein | Chemokine | CCR9 | CCR9 | TM3 | 3x47 | S | C | 1 | 1 | 1 |
5LWE
|
-0.53 (0.02−0.55) | 0 (0−0) | 0.18 (0.68−0.50) | -0.48 (-0.02−0.46) | — | — | — | 1 | — | — | |||
|
A (Rhodopsin) | Protein | Chemokine | CCR9 | CCR9 | TM5 | 5x41 | T | A | 1 | 1 | 1 |
5LWE
|
-0.02 (0.07−0.09) | 0 (0−0) | -0.66 (0−0.66) | 0.25 (0.50−0.25) | — | — | — | 3 | — | — | |||
|
A (Rhodopsin) | Protein | Chemokine | CCR9 | CCR9 | TM6 | 6x36 | V | A | 1 | 1 | 1 |
5LWE
|
-0.14 (0.01−0.15) | 0 (0−0) | -0.61 (0−0.61) | 0.96 (0.50−-0.46) | — | — | — | 6 | 1 | 5 | |||
|
A (Rhodopsin) | Protein | Chemokine | CCR9 | CCR9 | TM7 | 7x29 | N | A | 1 | 1 | 1 |
5LWE
|
0.12 (0.15−0.03) | 0 (0−0) | -0.65 (0−0.65) | -0.35 (0.50−0.85) | — | — | — | 2 | — | — | |||
|
A (Rhodopsin) | Protein | Chemokine | CCR9 | CCR9 | TM7 | 7x39 | T | A | 1 | 1 | 1 |
5LWE
|
0.05 (0.08−0.03) | 0 (0−0) | -0.66 (0−0.66) | 0.25 (0.50−0.25) | — | — | — | 20 | — | — | |||
|
A (Rhodopsin) | Lipid | Cannabinoid | CNR1 | CB1 | TM3 | 3x46 | T | A | 1 | 1 | 4 |
5XR8,
5XRA,
5TGZ,
5U09
|
0.0 (0.01−0.01) | 0 (0−0) | -0.66 (0−0.66) | 0.25 (0.50−0.25) | — | — | — | 1 | — | — | |||
|
A (Rhodopsin) | Lipid | Cannabinoid | CNR1 | CB1 | TM5 | 5x37 | E | K | 1 | 1 | 3 |
5XRA,
5TGZ,
5XR8
|
0.07 (0.11−0.04) | 0 (0−0) | -0.14 (0.26−0.40) | 2.69 (2.80−0.11) | — | — | — | 8 | — | — | |||
|
A (Rhodopsin) | Lipid | Cannabinoid | CNR1 | CB1 | TM6 | 6x32 | R | E | 1 | 1 | 3 |
5XRA,
5TGZ,
5XR8
|
-0.28 (0.04−0.32) | 0 (0−0) | 0.19 (0.40−0.21) | -1.70 (0.11−1.81) | — | — | — | — | 1 | 5 | |||
|
A (Rhodopsin) | Protein | Chemokine | CXCR4 | CXCR4 | ECL2 | 45x51 | D | C | 1 | 1 | 1 |
4RWS
|
-0.03 (0−0.03) | 0 (0−0) | -0.01 (0.68−0.69) | -0.45 (-0.02−0.43) | — | — | — | 111 | — | — | |||
|
A (Rhodopsin) | Protein | Chemokine | CXCR4 | CXCR4 | TM6 | 6x36 | T | P | 1 | 1 | 3 |
3OE0,
4RWS,
3OE9
|
-0.25 (0.0−0.25) | 0 (0−0) | 2.50 (3.16−0.66) | -0.11 (0.14−0.25) | — | — | — | 6 | 1 | 5 | |||
|
A (Rhodopsin) | Aminergic | Dopamine | DRD2 | D2 | TM3 | 3x40 | I | A | 1 | 1 | 1 |
6CM4
|
-0.34 (0.06−0.4) | 0 (0−0) | -0.41 (0−0.41) | 1.62 (0.50−-1.12) | — | — | — | 20 | — | — | |||
|
A (Rhodopsin) | Peptide | Endothelin | EDNRB | ETB | TM1 | 1x55 | R | Y | 1 | 1 | 2 |
5X93,
5XPR
|
0.07 (0.09−0.02) | 0 (0−0) | 0.32 (0.53−0.21) | -2.52 (-0.71−1.81) | — | — | — | — | — | — | |||
|
A (Rhodopsin) | Peptide | Endothelin | EDNRB | ETB | TM2 | 2x56 | D | A | 1 | 1 | 1 |
5X93
|
0.07 (0.08−0.01) | 0 (0−0) | -0.69 (0−0.69) | 0.07 (0.50−0.43) | — | — | — | 22 | — | — | |||
|
A (Rhodopsin) | Peptide | Endothelin | EDNRB | ETB | TM5 | 5x36 | K | A | 1 | 1 | 2 |
5X93,
5XPR
|
0.01 (0.06−0.05) | 0 (0−0) | -0.26 (0−0.26) | -2.30 (0.50−2.80) | — | — | — | 49 | — | — | |||
|
A (Rhodopsin) | Peptide | Endothelin | EDNRB | ETB | TM6 | 6x54 | S | A | 1 | 1 | 2 |
5X93,
5XPR
|
0.05 (0.1−0.05) | 0 (0−0) | -0.50 (0−0.50) | 0.04 (0.50−0.46) | — | — | — | 31 | — | — | |||
|
A (Rhodopsin) | Peptide | Endothelin | EDNRB | ETB | TM7 | 7x48 | I | A | 1 | 1 | 2 |
5X93,
5XPR
|
-0.02 (0.13−0.15) | 0 (0−0) | -0.41 (0−0.41) | 1.62 (0.50−-1.12) | — | — | — | 1 | — | — | |||
|
A (Rhodopsin) | Lipid | Free fatty acid | FFAR1 | FFA1 | TM2 | 2x40 | L | A | 1 | 1 | 4 |
5KW2,
5TZY,
5TZR,
4PHU
|
0.03 (0.06−0.03) | 0 (0−0) | -0.21 (0−0.21) | 1.75 (0.50−-1.25) | — | — | — | 4 | 1 | 1 | |||
|
A (Rhodopsin) | Lipid | Free fatty acid | FFAR1 | FFA1 | TM3 | 3x34 | F | A | 1 | 1 | 3 |
5KW2,
5TZR,
4PHU
|
-0.04 (0.07−0.11) | 0 (0−0) | -0.54 (0−0.54) | 2.21 (0.50−-1.71) | — | — | — | 3 | — | — | |||
|
A (Rhodopsin) | Lipid | Free fatty acid | FFAR1 | FFA1 | TM3 | 3x49 | G | A | 1 | 1 | 4 |
5KW2,
5TZY,
5TZR,
4PHU
|
0.0 (0.01−0.01) | 0 (0−0) | -1.00 (0−1.00) | -0.65 (0.50−1.15) | — | — | — | 2 | — | 2 | |||
|
A (Rhodopsin) | Lipid | Free fatty acid | FFAR1 | FFA1 | TM5 | 5x58 | Y | F | 1 | 1 | 4 |
5KW2,
5TZY,
5TZR,
4PHU
|
-0.73 (0.01−0.74) | 0 (0−0) | 0.01 (0.54−0.53) | -1.00 (-1.71−-0.71) | — | — | — | 4 | — | — | |||
|
A (Rhodopsin) | Lipid | Lysophospholipid (LPA) | LPAR1 | LPA1 | TM5 | 5x37 | D | C | 1 | 1 | 1 |
4Z36
|
-0.01 (0−0.01) | 0 (0−0) | -0.01 (0.68−0.69) | -0.45 (-0.02−0.43) | — | — | — | 8 | — | — | |||
|
A (Rhodopsin) | Lipid | Lysophospholipid (LPA) | LPAR1 | LPA1 | TM6 | 6x59 | V | C | 1 | 1 | 1 |
4Z36
|
-0.11 (0.01−0.12) | 0 (0−0) | 0.07 (0.68−0.61) | 0.44 (-0.02−-0.46) | — | — | — | 32 | — | — | |||
|
A (Rhodopsin) | Peptide | Neuropeptide Y | NPY1R | Y1 | TM3 | 3x41 | F | W | 1 | 1 | 2 |
5ZBQ,
5ZBH
|
-0.25 (0.03−0.28) | 0 (0−0) | -0.05 (0.49−0.54) | -0.38 (-2.09−-1.71) | — | — | — | 8 | — | — | |||
|
A (Rhodopsin) | Peptide | Neurotensin | NTR1 | NTS1 | TM1 | 1x54 | A | L | 1 | 1 | 22 |
6Z4Q,
6ZIN,
4BV0,
6Z66,
4BUO,
6Z8N,
6Z4V,
8FN0,
4XEE,
3ZEV,
4GRV,
8FMZ,
7L0S,
7L0P,
4XES,
6YVR,
4BWB,
7L0R,
5T04,
6Z4S,
6ZA8,
7L0Q
|
0.33 (0.37−0.04) | 0 (0−0) | 0.21 (0.21−0) | -1.75 (-1.25−0.50) | — | — | — | — | — | — | |||
|
A (Rhodopsin) | Peptide | Neurotensin | NTR1 | NTS1 | TM3 | 3x49 | E | A | 1 | 1 | 2 |
4XES,
4GRV
|
-0.2 (0.01−0.21) | 0 (0−0) | -0.40 (0−0.40) | 0.39 (0.50−0.11) | — | — | — | 2 | — | 2 | |||
|
A (Rhodopsin) | Peptide | Neurotensin | NTR1 | NTS1 | ECL2 | — | G | A | 1 | 1 | 4 |
4XES,
4XEE,
5T04,
4GRV
|
0 (0−0) | 0 (0−0) | -1.00 (0−1.00) | -0.65 (0.50−1.15) | — | — | — | — | — | — | |||
|
A (Rhodopsin) | Peptide | Neurotensin | NTR1 | NTS1 | TM5 | 5x54 | I | A | 1 | 1 | 4 |
4BUO,
3ZEV,
4BV0,
4BWB
|
-0.32 (0.01−0.33) | 0 (0−0) | -0.41 (0−0.41) | 1.62 (0.50−-1.12) | — | — | — | 4 | — | — | |||
|
A (Rhodopsin) | Peptide | Neurotensin | NTR1 | NTS1 | TM7 | 7x43 | V | A | 1 | 1 | 4 |
4XES,
4XEE,
5T04,
4GRV
|
0.09 (0.19−0.1) | 0 (0−0) | -0.61 (0−0.61) | 0.96 (0.50−-0.46) | — | — | — | 2 | — | — | |||
|
A (Rhodopsin) | Sensory | Opsins | OPSD OPSD | Rhodopsin | N-term | — | N | C | 2 | 1 | 19 |
5DGY,
5EN0,
6FKB,
4BEZ,
6FK7,
4BEY,
6FK8,
5W0P,
5DYS,
2X72,
6FKA,
6FKC,
6FK9,
2J4Y,
3C9M,
6FKD,
4A4M,
6FK6,
4ZWJ
|
0 (0−0) | 0 (0−0) | 0.03 (0.68−0.65) | -0.87 (-0.02−0.85) | — | — | — | — | — | — | |||
|
A (Rhodopsin) | Sensory | Opsins | OPSD | Rhodopsin | TM2 | 2x60 | T | I | 1 | 1 | 2 |
5EN0,
5DYS
|
-0.04 (0.04−0.08) | -0.13 (0.25−0.38) | -0.25 (0.41−0.66) | -1.37 (-1.12−0.25) | — | — | — | 96 | — | — | |||
|
A (Rhodopsin) | Sensory | Opsins | OPSD OPSD | Rhodopsin | TM3 | 3x28 | E | Q | 2 | 1 | 4 |
5DGY,
2X72,
5W0P,
4ZWJ
|
-0.01 (0.01−0.02) | -0.5 (0−0.5) | -0.01 (0.39−0.40) | 0.66 (0.77−0.11) | — | — | — | 57 | — | — | |||
|
A (Rhodopsin) | Sensory | Opsins | OPSD OPSD | Rhodopsin | TM6 | 6x40 | M | Y | 2 | 1 | 4 |
5DGY,
5W0P,
4ZWJ,
4A4M
|
-0.04 (0.01−0.05) | -0.75 (0−0.75) | 0.29 (0.53−0.24) | -0.04 (-0.71−-0.67) | — | — | — | 2 | 1 | — | |||
|
A (Rhodopsin) | Sensory | Opsins | OPSD | Rhodopsin | ECL3 | — | D | C | 1 | 1 | 16 |
5EN0,
6FKB,
4BEZ,
6FK7,
4BEY,
6FK8,
5DYS,
2X72,
6FKA,
6FKC,
6FK9,
2J4Y,
3C9M,
6FKD,
4A4M,
6FK6
|
0 (0−0) | 0 (0−0) | -0.01 (0.68−0.69) | -0.45 (-0.02−0.43) | — | — | — | — | — | — | |||
|
A (Rhodopsin) | Nucleotide | P2Y | P2Y12 P2RY1 | P2Y12 P2Y1 | TM7 | 7x49 | D | N | 2 | 1 | 6 |
4PXZ,
4XNW,
4XNV,
4NTJ,
4PY0,
7PP1
|
0.52 (0.72−0.2) | 0 (0−0) | -0.04 (0.65−0.69) | 0.42 (0.85−0.43) | — | — | — | — | — | — | |||
|
A (Rhodopsin) | Peptide | Proteinase-activated | PAR2 | PAR2 | TM1 | 1x46 | G | A | 1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
-0.43 (0.11−0.54) | 0 (0−0) | -1.00 (0−1.00) | -0.65 (0.50−1.15) | — | — | — | — | — | — | |||
|
A (Rhodopsin) | Peptide | Proteinase-activated | PAR2 | PAR2 | TM2 | 2x37 | H | A | 1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.02 (0.05−0.03) | 0 (0−0) | -0.61 (0−0.61) | 0.39 (0.50−0.11) | — | — | — | 3 | 1 | 1 | |||
|
A (Rhodopsin) | Peptide | Proteinase-activated | PAR2 | PAR2 | TM3 | 3x34 | G | A | 1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.05 (0.07−0.02) | 0 (0−0) | -1.00 (0−1.00) | -0.65 (0.50−1.15) | — | — | — | 3 | — | — | |||
|
A (Rhodopsin) | Peptide | Proteinase-activated | PAR2 | PAR2 | TM3 | 3x43 | M | L | 1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.68 (0.73−0.05) | 0 (0−0) | -0.03 (0.21−0.24) | -0.58 (-1.25−-0.67) | — | — | — | 2 | — | — | |||
|
A (Rhodopsin) | Peptide | Proteinase-activated | PAR2 | PAR2 | TM3 | 3x51 | Y | A | 1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
-0.66 (0.0−0.66) | 0 (0−0) | -0.53 (0−0.53) | 1.21 (0.50−-0.71) | — | — | — | 1 | — | — | |||
|
A (Rhodopsin) | Peptide | Proteinase-activated | PAR2 | PAR2 | TM3 | 3x53 | V | E | 1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
-0.06 (0.01−0.07) | 0 (0−0) | -0.21 (0.40−0.61) | 0.57 (0.11−-0.46) | — | — | — | — | — | 5 | |||
|
A (Rhodopsin) | Peptide | Proteinase-activated | PAR2 | PAR2 | TM5 | 5x64 | M | A | 1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.11 (0.12−0.01) | 0 (0−0) | -0.24 (0−0.24) | 1.17 (0.50−-0.67) | — | — | — | — | 1 | 3 | |||
|
A (Rhodopsin) | Peptide | Proteinase-activated | PAR2 | PAR2 | TM6 | 6x38 | I | A | 1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
0.06 (0.14−0.08) | 0 (0−0) | -0.41 (0−0.41) | 1.62 (0.50−-1.12) | — | — | — | 4 | — | — | |||
|
A (Rhodopsin) | Peptide | Proteinase-activated | PAR2 | PAR2 | TM6 | 6x42 | L | A | 1 | 1 | 3 |
5NDZ,
5NDD,
5NJ6
|
-0.12 (0.13−0.25) | 0 (0−0) | -0.21 (0−0.21) | 1.75 (0.50−-1.25) | — | — | — | 1 | — | — | |||
|
A (Rhodopsin) | Lipid | Platelet-activating factor | PTAFR | PAF | TM6 | 6x34 | A | D | 1 | 1 | 2 |
5ZKQ,
5ZKP
|
-0.24 (0−0.24) | 0 (0−0) | 0.69 (0.69−0) | -0.07 (0.43−0.50) | — | — | — | 2 | — | — | |||
|
A (Rhodopsin) | Lipid | Leukotriene | Q9WTK1 | BLT1 | TM2 | 2x67 | H | G | 1 | 1 | 1 |
5X33
|
0.2 (0.27−0.07) | 0 (0−0) | 0.39 (1.00−0.61) | 1.04 (1.15−0.11) | — | — | — | 15 | — | — | |||
|
A (Rhodopsin) | Lipid | Leukotriene | Q9WTK1 | BLT1 | TM3 | 3x21 | K | G | 1 | 1 | 1 |
5X33
|
0.67 (0.68−0.01) | 0 (0−0) | 0.74 (1.00−0.26) | -1.65 (1.15−2.80) | — | — | — | 7 | — | — | |||
|
A (Rhodopsin) | Lipid | Leukotriene | Q9WTK1 | BLT1 | TM5 | 5x67 | V | A | 1 | 1 | 1 |
5X33
|
0.06 (0.09−0.03) | 0 (0−0) | -0.61 (0−0.61) | 0.96 (0.50−-0.46) | — | — | — | — | — | 1 | |||
|
A (Rhodopsin) | Lipid | Leukotriene | Q9WTK1 | BLT1 | C-term | — | S | A | 1 | 1 | 1 |
5X33
|
0 (0−0) | 0 (0−0) | -0.50 (0−0.50) | 0.04 (0.50−0.46) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Corticotropin-releasing factor | CRFR1 | CRF1 | TM1 | 1x36 | V | A | 1 | 1 | 5 |
8GTG,
4K5Y,
8GTM,
4Z9G,
8GTI
|
-0.07 (0−0.07) | 0 (0−0) | -0.61 (0−0.61) | 0.96 (0.50−-0.46) | — | — | — | 13 | — | — | |||
|
B1 (Secretin) | Peptide | Corticotropin-releasing factor | CRFR1 | CRF1 | TM1 | 1x60 | L | A | 1 | 1 | 5 |
8GTG,
4K5Y,
8GTM,
4Z9G,
8GTI
|
-0.33 (0−0.33) | 0 (0−0) | -0.21 (0−0.21) | 1.75 (0.50−-1.25) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Corticotropin-releasing factor | CRFR1 | CRF1 | TM2 | 2x44 | W | A | 1 | 1 | 2 |
4Z9G,
4K5Y
|
-0.06 (0.07−0.13) | 0 (0−0) | -0.49 (0−0.49) | 2.59 (0.50−-2.09) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Corticotropin-releasing factor | CRFR1 | CRF1 | TM2 | 2x48 | S | A | 1 | 1 | 2 |
4Z9G,
4K5Y
|
0.13 (0.2−0.07) | 0 (0−0) | -0.50 (0−0.50) | 0.04 (0.50−0.46) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Corticotropin-releasing factor | CRFR1 | CRF1 | TM4 | 4x43 | K | A | 1 | 1 | 2 |
4Z9G,
4K5Y
|
-0.13 (0−0.13) | 0 (0−0) | -0.26 (0−0.26) | -2.30 (0.50−2.80) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Corticotropin-releasing factor | CRFR1 | CRF1 | ECL2 | 45x52 | F | A | 1 | 1 | 2 |
4Z9G,
4K5Y
|
-0.13 (0−0.13) | 0 (0−0) | -0.54 (0−0.54) | 2.21 (0.50−-1.71) | — | — | — | 15 | — | — | |||
|
B1 (Secretin) | Peptide | Corticotropin-releasing factor | CRFR1 | CRF1 | TM5 | 5x48 | I | A | 1 | 1 | 2 |
4Z9G,
4K5Y
|
-0.2 (0−0.2) | 0 (0−0) | -0.41 (0−0.41) | 1.62 (0.50−-1.12) | — | — | — | 6 | — | — | |||
|
B1 (Secretin) | Peptide | Corticotropin-releasing factor | CRFR1 | CRF1 | TM6 | 6x30 | Y | A | 1 | 1 | 2 |
4Z9G,
4K5Y
|
-0.73 (0−0.73) | 0 (0−0) | -0.53 (0−0.53) | 1.21 (0.50−-0.71) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Corticotropin-releasing factor | CRFR1 | CRF1 | TM6 | 6x51 | F | A | 1 | 1 | 2 |
4Z9G,
4K5Y
|
-0.93 (0−0.93) | 0 (0−0) | -0.54 (0−0.54) | 2.21 (0.50−-1.71) | — | — | — | 3 | — | — | |||
|
B1 (Secretin) | Peptide | Corticotropin-releasing factor | CRFR1 | CRF1 | TM7 | 7x38 | S | A | 1 | 1 | 2 |
4Z9G,
4K5Y
|
-0.13 (0−0.13) | 0 (0−0) | -0.50 (0−0.50) | 0.04 (0.50−0.46) | — | — | — | 15 | — | — | |||
|
B1 (Secretin) | Peptide | Corticotropin-releasing factor | CRFR1 | CRF1 | TM7 | 7x53 | Y | A | 1 | 1 | 2 |
4Z9G,
4K5Y
|
-0.93 (0−0.93) | 0 (0−0) | -0.53 (0−0.53) | 1.21 (0.50−-0.71) | — | — | Removed | 1 | — | 1 | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | TM2 | 2x56 | S | C | 1 | 1 | 2 |
5VEW,
5VEX
|
-0.47 (0−0.47) | 0 (0−0) | 0.18 (0.68−0.50) | -0.48 (-0.02−0.46) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | TM2 | 2x59 | I | F | 1 | 1 | 2 |
5VEW,
5VEX
|
-0.4 (0−0.4) | 0 (0−0) | 0.13 (0.54−0.41) | -0.59 (-1.71−-1.12) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | ECL1 | — | T | E | 1 | 1 | 1 |
5NX2
|
0 (0−0) | 0 (0−0) | -0.26 (0.40−0.66) | -0.14 (0.11−0.25) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | ECL1 | — | Q | A | 1 | 1 | 1 |
5NX2
|
0 (0−0) | 0 (0−0) | -0.39 (0−0.39) | -0.27 (0.50−0.77) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | ECL1 | — | D | R | 1 | 1 | 1 |
5NX2
|
0 (0−0) | 0 (0−0) | -0.48 (0.21−0.69) | 1.38 (1.81−0.43) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | TM3 | 3x24 | S | A | 1 | 1 | 2 |
5VEW,
5VEX
|
-0.2 (0.07−0.27) | 0 (0−0) | -0.50 (0−0.50) | 0.04 (0.50−0.46) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | TM3 | 3x31 | L | F | 1 | 1 | 1 |
5NX2
|
0.2 (0.4−0.2) | 0 (0−0) | 0.33 (0.54−0.21) | -0.46 (-1.71−-1.25) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | TM3 | 3x32 | M | C | 1 | 1 | 2 |
5VEW,
5VEX
|
-0.13 (0−0.13) | 0 (0−0) | 0.44 (0.68−0.24) | 0.65 (-0.02−-0.67) | — | — | — | 12 | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | ICL2 | — | L | F | 1 | 1 | 1 |
5NX2
|
0 (0−0) | 0 (0−0) | 0.33 (0.54−0.21) | -0.46 (-1.71−-1.25) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | TM4 | 4x48 | S | A | 1 | 1 | 2 |
5VEW,
5VEX
|
0.0 (0.07−0.07) | 0 (0−0) | -0.50 (0−0.50) | 0.04 (0.50−0.46) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | ECL2 | — | G | A | 1 | 1 | 1 |
5NX2
|
0 (0−0) | 0 (0−0) | -1.00 (0−1.00) | -0.65 (0.50−1.15) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | ECL2 | 45x52 | T | A | 1 | 1 | 1 |
5NX2
|
-0.2 (0−0.2) | 0 (0−0) | -0.66 (0−0.66) | 0.25 (0.50−0.25) | — | — | — | 15 | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | TM5 | 5x51 | I | C | 1 | 1 | 2 |
5VEW,
5VEX
|
-0.6 (0−0.6) | 0 (0−0) | 0.27 (0.68−0.41) | 1.10 (-0.02−-1.12) | — | — | — | 1 | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | TM5 | 5x52 | G | I | 1 | 1 | 2 |
5VEW,
5VEX
|
-0.13 (0.07−0.2) | 0 (0−0) | -0.59 (0.41−1.00) | -2.27 (-1.12−1.15) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | TM5 | 5x63 | C | A | 1 | 1 | 1 |
5NX2
|
-0.07 (0−0.07) | 0 (0−0) | -0.68 (0−0.68) | 0.52 (0.50−-0.02) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R GLR | glucagon GLP-1 | TM6 | 6x30 | K | A | 2 | 1 | 3 |
5EE7,
5VEW,
5VEX
|
-0.2 (0−0.2) | 0 (0−0) | -0.26 (0−0.26) | -2.30 (0.50−2.80) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | TM6 | 6x31 | C | F | 1 | 1 | 2 |
5VEW,
5VEX
|
0.0 (0.07−0.07) | 0 (0−0) | -0.14 (0.54−0.68) | -1.69 (-1.71−-0.02) | — | — | — | 1 | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | TM6 | 6x42 | P | A | 1 | 1 | 1 |
5NX2
|
-0.93 (0−0.93) | 0 (0−0) | -3.16 (0−3.16) | 0.36 (0.50−0.14) | — | — | — | 2 | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | TM6 | 6x45 | G | A | 1 | 1 | 1 |
5NX2
|
-1.0 (0−1.0) | 0 (0−0) | -1.00 (0−1.00) | -0.65 (0.50−1.15) | — | — | — | 1 | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | TM6 | 6x45 | G | C | 1 | 1 | 2 |
5VEW,
5VEX
|
-1.0 (0−1.0) | 0 (0−0) | -0.32 (0.68−1.00) | -1.17 (-0.02−1.15) | — | — | — | 1 | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | TM6 | 6x47 | H | V | 1 | 1 | 1 |
5NX2
|
-0.73 (0−0.73) | 0 (0−0) | 0.00 (0.61−0.61) | -0.57 (-0.46−0.11) | — | — | — | 2 | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLP1R | GLP-1 | TM7 | 7x56 | V | A | 1 | 1 | 1 |
5NX2
|
0.0 (0.07−0.07) | 0 (0−0) | -0.61 (0−0.61) | 0.96 (0.50−-0.46) | — | — | — | 1 | — | 2 | |||
|
B1 (Secretin) | Peptide | Glucagon | GLR | glucagon | TM1 | 1x48 | G | A | 1 | 1 | 1 |
5EE7
|
0.2 (0.33−0.13) | 0 (0−0) | -1.00 (0−1.00) | -0.65 (0.50−1.15) | — | — | — | 2 | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLR | glucagon | TM2 | 2x39 | R | A | 1 | 1 | 2 |
5EE7,
5YQZ
|
-1.0 (0−1.0) | 0 (0−0) | -0.21 (0−0.21) | -1.31 (0.50−1.81) | — | — | — | 1 | — | 2 | |||
|
B1 (Secretin) | Peptide | Glucagon | GLR | glucagon | TM2 | 2x48 | A | L | 1 | 1 | 1 |
5EE7
|
0.0 (0.2−0.2) | 0 (0−0) | 0.21 (0.21−0) | -1.75 (-1.25−0.50) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLR | glucagon | TM2 | 2x56 | S | A | 1 | 1 | 1 |
5EE7
|
-0.2 (0.27−0.47) | 0 (0−0) | -0.50 (0−0.50) | 0.04 (0.50−0.46) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLR | glucagon | TM2 | 2x59 | V | F | 1 | 1 | 1 |
5EE7
|
-0.4 (0−0.4) | 0 (0−0) | -0.07 (0.54−0.61) | -1.25 (-1.71−-0.46) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLR | glucagon | ECL1 | — | G | E | 1 | 1 | 1 |
5EE7
|
0 (0−0) | 0 (0−0) | -0.60 (0.40−1.00) | -1.04 (0.11−1.15) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLR | glucagon | TM3 | 3x24 | G | A | 1 | 1 | 1 |
5EE7
|
-0.33 (0.07−0.4) | 0 (0−0) | -1.00 (0−1.00) | -0.65 (0.50−1.15) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLR | glucagon | TM4 | 4x54 | M | A | 1 | 1 | 1 |
5EE7
|
0.2 (0.27−0.07) | 0 (0−0) | -0.24 (0−0.24) | 1.17 (0.50−-0.67) | — | — | — | — | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLR | glucagon | TM6 | 6x48 | E | F | 1 | 1 | 1 |
5EE7
|
-0.14 (0.13−0.27) | 0 (0−0) | 0.14 (0.54−0.40) | -1.82 (-1.71−0.11) | — | — | — | 6 | — | — | |||
|
B1 (Secretin) | Peptide | Glucagon | GLR | glucagon | TM7 | 7x39 | F | A | 1 | 1 | 1 |
5EE7
|
-0.26 (0.07−0.33) | 0 (0−0) | -0.54 (0−0.54) | 2.21 (0.50−-1.71) | — | — | — | — | — | — | |||
|
C (Glutamate) | Amino acid | Metabotropic glutamate | GRM5 | mGlu5 | TM1 | 1x35 | E | A | 1 | 1 | 6 |
5CGD,
6FFH,
6FFI,
4OO9,
5CGC,
7P2L
|
-0.04 (0.05−0.09) | 0 (0−0) | -0.40 (0−0.40) | 0.39 (0.50−0.11) | — | — | — | — | — | — | |||
|
C (Glutamate) | Amino acid | Metabotropic glutamate | GRM5 | mGlu5 | TM3 | 3x48 | N | Y | 1 | 1 | 6 |
5CGD,
6FFH,
6FFI,
4OO9,
5CGC,
7P2L
|
-0.36 (0.05−0.41) | 0 (0−0) | -0.12 (0.53−0.65) | -1.56 (-0.71−0.85) | — | — | — | — | — | — | |||
|
C (Glutamate) | Amino acid | Metabotropic glutamate | GRM5 | mGlu5 | TM3 | 3x50 | I | A | 1 | 1 | 6 |
5CGD,
6FFH,
6FFI,
4OO9,
5CGC,
7P2L
|
-0.4 (0.05−0.45) | 0 (0−0) | -0.41 (0−0.41) | 1.62 (0.50−-1.12) | — | — | — | — | — | — | |||
|
C (Glutamate) | Amino acid | Metabotropic glutamate | GRM5 | mGlu5 | ICL2 | — | G | M | 1 | 1 | 6 |
5CGD,
6FFH,
6FFI,
4OO9,
5CGC,
7P2L
|
0 (0−0) | 0 (0−0) | -0.76 (0.24−1.00) | -1.82 (-0.67−1.15) | — | — | — | — | — | — | |||
|
C (Glutamate) | Amino acid | Metabotropic glutamate | GRM5 | mGlu5 | TM5 | 5x42 | T | A | 1 | 1 | 15 |
7FD9,
6FFH,
8X0D,
8X0G,
5CGC,
8X0E,
8X0F,
7FD8,
5CGD,
6FFI,
8X0B,
8X0H,
8X0C,
4OO9,
7P2L
|
-0.04 (0.05−0.09) | 0 (0−0) | -0.66 (0−0.66) | 0.25 (0.50−0.25) | — | — | — | — | — | — | |||
|
C (Glutamate) | Amino acid | Metabotropic glutamate | GRM5 | mGlu5 | TM5 | 5x53 | S | A | 1 | 1 | 15 |
7FD9,
6FFH,
8X0D,
8X0G,
5CGC,
8X0E,
8X0F,
7FD8,
5CGD,
6FFI,
8X0B,
8X0H,
8X0C,
4OO9,
7P2L
|
-0.14 (0−0.14) | 0 (0−0) | -0.50 (0−0.50) | 0.04 (0.50−0.46) | — | — | — | — | — | — | |||
|
F (Frizzled) | Protein | Frizzled | SMO | SMO | TM3 | 3x40 | V | F | 1 | 1 | 2 |
5L7D,
5L7I
|
-0.09 (0−0.09) | -0.09 (0−0.09) | -0.07 (0.54−0.61) | -1.25 (-1.71−-0.46) | — | — | — | 1 | — | — | |||
|
A (Rhodopsin) | Nucleotide | Adenosine | AA2AR | A2A | TM3 | 3x39 | S | A | 1 | 1 | 1 |
5WF6
|
-0.69 (0.03−0.72) | 0 (0−0) | -0.50 (0−0.50) | 0.04 (0.50−0.46) | — | Removed | — | 5 | — | — | |||