Stabilising Mutation Analyser

Group by: Mutant Subsets: Only show mutations present in minimum 2 GPCRs
STATE TARGETS MUTATIONS FREQUENCY SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS
No. Receptor Families
No. Structures
PDBs Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Active
Intermediate
Inactive
A (Rhodopsin)
Protein
Aminergic
Peptide
Adrenoceptors
Chemokine
Dopamine
Neuropeptide Y
5-Hydroxytryptamine
ADRB1
ADRB2
NPY1R
DRD3
5HT1B
CXCR4
5HT2B
β2
Y1
5-HT2B
5-HT1B
β1
CXCR4
D3
TM3 3x41
F
M
L
E
W
7 5 28
3NY9, 3ODU, 4IB4, 5ZBH, 5TUD, 4IAR, 3OE9, 6DRZ, 3NYA, 3NY8, 5V54, 4NC3, 5A8E, 6DS0, 6DRY, 3OE8, 6DRX, 5ZBQ, 9F34, 3OE0, 9F33, 3D4S, 3OE6, 4IAQ, 5TVN, 7C61, 4RWS, 3PBL
8
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N
1 1 2
6BQH, 6BQG
Pos Match 5
Active
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM2 2x52
A
L
2 1 28
5IUB, 5N2S, 5NM4, 3PWH, 5OLO, 4UG2, 3UZA, 5MZP, 5OLZ, 5IU7, 2YDO, 3REY, 4UHR, 2YDV, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 5OM1, 3UZC, 5OM4, 5N2R, 5NM2, 5OLG, 3RFM
2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM3 3x36
T
A
2 1 24
5IUB, 5N2S, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
115
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM5 5x63
L
Y
A
2 1 24
5IUB, 5N2S, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
Active
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Peptide
Dopamine
Adenosine
Neurotensin
NTR1
AA2AR
DRD2
AA1R
A1
A2A
D2
NTS1
TM6 6x37
L
A
4 3 26
5IUB, 5N2S, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 4GRV, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 6CM4, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
7 1 4
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Dopamine
Adenosine
AA2AR
DRD2
AA1R
A1
A2A
D2
TM6 6x41
L
V
A
3 2 25
5IUB, 5N2S, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 6CM4, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM7 7x41
S
T
A
2 1 24
5IUB, 5N2S, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
62
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A
1 1 4
4UHR, 2YDV, 4UG2, 2YDO
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N
1 1 1
5WF5
Pos Match 3
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A
1 1 4
4UHR, 2YDV, 4UG2, 2YDO
6
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A
1 1 4
4UHR, 2YDV, 4UG2, 2YDO
67
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A
1 1 23
5IUB, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
1 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A
1 1 23
5IUB, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S
1 1 24
4BVN, 6IBL, 4GPO, 2YCY, 6H7L, 3ZPR, 2Y04, 6H7N, 3ZPQ, 2Y00, 2VT4, 2Y02, 5A8E, 2YCX, 6H7O, 2Y03, 6H7J, 4AMJ, 2Y01, 6H7M, 4AMI, 5F8U, 2YCZ, 2YCW
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V
1 1 25
4BVN, 6IBL, 4GPO, 2YCY, 6H7L, 3ZPR, 2Y04, 6H7N, 6TKO, 3ZPQ, 2Y00, 2VT4, 2Y02, 5A8E, 2YCX, 6H7O, 2Y03, 6H7J, 4AMJ, 2Y01, 6H7M, 4AMI, 5F8U, 2YCZ, 2YCW
23
Inactive
A (Rhodopsin)
Aminergic
Peptide
Adrenoceptors
Apelin
Dopamine
ADRB1
APJ
DRD2
apelin
D2
β1
TM3 3x40
I
V
A
V
3 3 4
5VBL, 4BVN, 5A8E, 6CM4
20
Active
Inactive
A (Rhodopsin)
Aminergic
Lipid
Adrenoceptors
Free fatty acid
ADRB1
FFAR1
β1
FFA1
TM5 5x58
Y
F
A
2 2 22
5TZY, 4BVN, 4GPO, 2YCY, 3ZPR, 2Y04, 3ZPQ, 2Y00, 2VT4, 2Y02, 5A8E, 2YCX, 4PHU, 5KW2, 2Y03, 4AMJ, 2Y01, 5TZR, 4AMI, 5F8U, 2YCZ, 2YCW
4
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L
1 1 18
4BVN, 2Y03, 5F8U, 4AMJ, 4GPO, 2YCY, 5A8E, 4AMI, 2Y04, 3ZPR, 2VT4, 2Y01, 3ZPQ, 2Y00, 2Y02, 2YCX, 2YCZ, 2YCW
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K
1 1 1
4BVN
67
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A
1 1 25
4BVN, 6IBL, 4GPO, 2YCY, 6H7L, 3ZPR, 2Y04, 6H7N, 6TKO, 3ZPQ, 2Y00, 2VT4, 2Y02, 5A8E, 2YCX, 6H7O, 2Y03, 6H7J, 4AMJ, 2Y01, 6H7M, 4AMI, 5F8U, 2YCZ, 2YCW
3
Active
Inactive
A (Rhodopsin)
Aminergic
Peptide
Adrenoceptors
Endothelin
EDNRB
ADRB1
β1
ETB
TM7 7x48
F
I
A
M
2 2 27
4BVN, 5X93, 5XPR, 6IBL, 4GPO, 2YCY, 6H7L, 3ZPR, 2Y04, 6H7N, 6TKO, 3ZPQ, 2Y00, 2VT4, 2Y02, 5A8E, 2YCX, 6H7O, 2Y03, 6H7J, 4AMJ, 2Y01, 6H7M, 4AMI, 5F8U, 2YCZ, 2YCW
1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L
1 1 2
4BVN, 5A8E
Pos Match Pos Match 8
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C
1 1 2
4QKX, 3PDS
70
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K
1 1 1
5VBL
Pos Match 82
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y
1 1 5
4MBS, 6AKX, 5UIW, 6AKY, 7F1T
1 2
Active
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N
1 1 8
4MBS, 6AKX, 5UIW, 6AKY, 7F1Q, 7F1S, 7F1R, 7F1T
49
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D
1 1 5
4MBS, 6AKX, 5UIW, 6AKY, 7F1T
4 1 6
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E
1 1 5
4MBS, 6AKX, 5UIW, 6AKY, 7F1T
4 1 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A
1 1 1
5LWE
4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A
1 1 1
5LWE
2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A
1 1 1
5LWE
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C
1 1 1
5LWE
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A
1 1 1
5LWE
3
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CXCR4
CXCR4
CCR9
TM6 6x36
T
V
A
P
2 1 4
3OE9, 5LWE, 4RWS, 3OE0
6 1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A
1 1 1
5LWE
2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A
1 1 1
5LWE
20
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A
1 1 4
5XRA, 5TGZ, 5U09, 5XR8
1
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
Lysophospholipid (LPA)
LPAR1
CNR1
CB1
LPA1
TM5 5x37
D
E
K
C
2 2 4
5XRA, 5TGZ, 4Z36, 5XR8
8
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E
1 1 3
5XRA, 5TGZ, 5XR8
1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C
1 1 1
4RWS
108
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y
1 1 2
5X93, 5XPR
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A
1 1 1
5X93
22
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A
1 1 2
5X93, 5XPR
48
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A
1 1 2
5X93, 5XPR
31
Active
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A
1 1 4
4PHU, 5TZY, 5TZR, 5KW2
4 1 1
Active
A (Rhodopsin)
Peptide
Lipid
Proteinase-activated
Free fatty acid
FFAR1
PAR2
PAR2
FFA1
TM3 3x34
F
G
A
2 2 6
4PHU, 5NDZ, 5NJ6, 5TZR, 5NDD, 5KW2
3
Active
A (Rhodopsin)
Peptide
Lipid
Neurotensin
Free fatty acid
NTR1
FFAR1
FFA1
NTS1
TM3 3x49
G
E
A
2 2 6
4PHU, 5TZY, 4XES, 5TZR, 4GRV, 5KW2
Pos Match 2 2
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C
1 1 1
4Z36
32
Inactive
Intermediate
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L
1 1 22
5T04, 8FMZ, 7L0P, 4BUO, 3ZEV, 4XES, 4XEE, 4GRV, 6ZIN, 6Z4Q, 8FN0, 7L0R, 7L0Q, 4BV0, 6Z66, 6Z4V, 6Z8N, 7L0S, 6YVR, 6ZA8, 6Z4S, 4BWB
Inactive
Active
A (Rhodopsin)
Lipid
Sensory
Peptide
Leukotriene
Neurotensin
Opsins
Q9WTK1
OPSD
NTR1
OPSD
BLT1
Rhodopsin
NTS1
ECL2
S
G
D
N
A
C
4 3 24
5T04, 6FKD, 5W0P, 4BEZ, 5EN0, 4BEY, 4A4M, 6FK9, 5DGY, 6FK6, 4XES, 3C9M, 4ZWJ, 2X72, 4XEE, 4GRV, 5DYS, 6FK7, 6FK8, 6FKC, 5X33, 6FKA, 2J4Y, 6FKB
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A
1 1 4
3ZEV, 4BV0, 4BWB, 4BUO
4
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A
1 1 4
5T04, 4XEE, 4XES, 4GRV
2
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I
1 1 2
5EN0, 5DYS
93
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q
2 1 4
4ZWJ, 2X72, 5DGY, 5W0P
57
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y
2 1 4
4A4M, 5W0P, 5DGY, 4ZWJ
2 1
Active
A (Rhodopsin)
Nucleotide
P2Y
P2RY1
P2Y12
P2Y1
P2Y12
TM7 7x49
D
N
2 1 6
4XNW, 4PXZ, 4PY0, 4XNV, 7PP1, 4NTJ
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A
1 1 3
5NJ6, 5NDZ, 5NDD
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A
1 1 3
5NJ6, 5NDZ, 5NDD
3 1 1
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L
1 1 3
5NJ6, 5NDZ, 5NDD
2
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A
1 1 3
5NJ6, 5NDZ, 5NDD
1
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E
1 1 3
5NJ6, 5NDZ, 5NDD
5
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A
1 1 3
5NJ6, 5NDZ, 5NDD
1 3
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A
1 1 3
5NJ6, 5NDZ, 5NDD
4
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A
1 1 3
5NJ6, 5NDZ, 5NDD
1
Active
Other
A (Rhodopsin)
Lipid
Platelet-activating factor
PTAFR
PAF
TM6 6x34
A
D
1 1 2
5ZKQ, 5ZKP
2
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G
1 1 1
5X33
15
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G
1 1 1
5X33
7
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A
1 1 1
5X33
1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A
1 1 5
8GTG, 8GTI, 4K5Y, 8GTM, 4Z9G
13
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A
1 1 5
8GTG, 8GTI, 4K5Y, 8GTM, 4Z9G
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A
1 1 2
4K5Y, 4Z9G
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLR
CRF1
glucagon
TM2 2x48
A
S
L
A
2 2 3
4K5Y, 5EE7, 4Z9G
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A
1 1 2
4K5Y, 4Z9G
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLP1R
GLP-1
CRF1
ECL2 45x52
F
T
A
2 2 3
4K5Y, 5NX2, 4Z9G
15
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A
1 1 2
4K5Y, 4Z9G
6
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLR
GLP1R
GLP-1
CRF1
glucagon
TM6 6x30
K
Y
A
3 2 5
5VEW, 5VEX, 4K5Y, 5EE7, 4Z9G
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A
1 1 2
4K5Y, 4Z9G
3
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A
1 1 2
4K5Y, 4Z9G
15
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A
1 1 2
4K5Y, 4Z9G
Pos Match 1 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM2 2x56
S
A
C
2 1 3
5VEW, 5EE7, 5VEX
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM2 2x59
I
V
F
2 1 3
5VEW, 5EE7, 5VEX
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
ECL1
Q
L
G
D
T
F
R
A
E
2 1 2
5EE7, 5NX2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM3 3x24
G
S
A
2 1 3
5VEW, 5EE7, 5VEX
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C
1 1 2
5VEW, 5VEX
12
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A
1 1 2
5VEW, 5VEX
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C
1 1 2
5VEW, 5VEX
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I
1 1 2
5VEW, 5VEX
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F
1 1 2
5VEW, 5VEX
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A
1 1 1
5NX2
2
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A
C
1 1 3
5VEW, 5VEX, 5NX2
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V
1 1 1
5NX2
2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A
1 1 1
5NX2
1 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A
1 1 1
5EE7
2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A
1 1 2
5YQZ, 5EE7
1 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A
1 1 1
5EE7
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F
1 1 1
5EE7
6
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A
1 1 1
5EE7
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A
1 1 6
7P2L, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y
1 1 6
7P2L, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A
1 1 6
7P2L, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
Pos Match
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M
1 1 6
7P2L, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
Active
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A
1 1 8
7P2L, 7FD9, 7FD8, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
Active
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A
1 1 8
7P2L, 7FD9, 7FD8, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F
1 1 2
5L7I, 5L7D
1
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A
1 1 1
5WF6
Pos Match 5
STATE TARGETS MUTATIONS FREQUENCY DATA (MUTANT) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Active
Intermediate
Inactive
A (Rhodopsin)
Protein
Aminergic
Peptide
Adrenoceptors
Chemokine
Dopamine
Neuropeptide Y
5-Hydroxytryptamine
ADRB1
ADRB2
NPY1R
DRD3
5HT1B
CXCR4
5HT2B
β2
Y1
5-HT2B
5-HT1B
β1
CXCR4
D3
TM3 3x41
F
M
L
E
W 7 5 28
3NY9, 3ODU, 4IB4, 5ZBH, 5TUD, 4IAR, 3OE9, 6DRZ, 3NYA, 3NY8, 5V54, 4NC3, 5A8E, 6DS0, 6DRY, 3OE8, 6DRX, 5ZBQ, 9F34, 3OE0, 9F33, 3D4S, 3OE6, 4IAQ, 5TVN, 7C61, 4RWS, 3PBL
0.03 0.49 -2.09 8
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N 1 1 2
6BQH, 6BQG
0.67 0.65 0.85 Pos & AA Mutant Match 5
Active
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM2 2x52
A
L 2 1 28
5IUB, 5N2S, 5NM4, 3PWH, 5OLO, 4UG2, 3UZA, 5MZP, 5OLZ, 5IU7, 2YDO, 3REY, 4UHR, 2YDV, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 5OM1, 3UZC, 5OM4, 5N2R, 5NM2, 5OLG, 3RFM
0.63 0.21 -1.25 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM3 3x36
T
A 2 1 24
5IUB, 5N2S, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
0.02 0 0.50 115
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM5 5x63
L
Y
A 2 1 24
5IUB, 5N2S, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
0.05 0 0.50
Active
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Peptide
Dopamine
Adenosine
Neurotensin
NTR1
AA2AR
DRD2
AA1R
A1
A2A
D2
NTS1
TM6 6x37
L
A 4 3 26
5IUB, 5N2S, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 4GRV, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 6CM4, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
0.04 0 0.50 7 1 4
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Dopamine
Adenosine
AA2AR
DRD2
AA1R
A1
A2A
D2
TM6 6x41
L
V
A 3 2 25
5IUB, 5N2S, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 6CM4, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
0.05 0 0.50 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM7 7x41
S
T
A 2 1 24
5IUB, 5N2S, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
0.38 0 0.50 62
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A 1 1 4
4UHR, 2YDV, 4UG2, 2YDO
0 0.50
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N 1 1 1
5WF5
0.03 0.65 0.85 Pos & AA Mutant Match 3
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A 1 1 4
4UHR, 2YDV, 4UG2, 2YDO
0.12 0 0.50 6
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A 1 1 4
4UHR, 2YDV, 4UG2, 2YDO
0.03 0 0.50 67
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A 1 1 23
5IUB, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
0.08 0 0.50 1 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A 1 1 23
5IUB, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
0.13 0 0.50 1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S 1 1 24
4BVN, 6IBL, 4GPO, 2YCY, 6H7L, 3ZPR, 2Y04, 6H7N, 3ZPQ, 2Y00, 2VT4, 2Y02, 5A8E, 2YCX, 6H7O, 2Y03, 6H7J, 4AMJ, 2Y01, 6H7M, 4AMI, 5F8U, 2YCZ, 2YCW
0.04 0.50 0.46
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V 1 1 25
4BVN, 6IBL, 4GPO, 2YCY, 6H7L, 3ZPR, 2Y04, 6H7N, 6TKO, 3ZPQ, 2Y00, 2VT4, 2Y02, 5A8E, 2YCX, 6H7O, 2Y03, 6H7J, 4AMJ, 2Y01, 6H7M, 4AMI, 5F8U, 2YCZ, 2YCW
0.23 0.33 0.61 -0.46 23
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM3 3x40
I
V 1 1 2
4BVN, 5A8E
0.24 0.61 -0.46 20
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM5 5x58
Y
A 1 1 18
4BVN, 2Y03, 5F8U, 4AMJ, 4GPO, 2YCY, 5A8E, 4AMI, 2Y04, 3ZPR, 2VT4, 2Y01, 3ZPQ, 2Y00, 2Y02, 2YCX, 2YCZ, 2YCW
0.02 0 0.50 4
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L 1 1 18
4BVN, 2Y03, 5F8U, 4AMJ, 4GPO, 2YCY, 5A8E, 4AMI, 2Y04, 3ZPR, 2VT4, 2Y01, 3ZPQ, 2Y00, 2Y02, 2YCX, 2YCZ, 2YCW
0.11 0.11 0.21 -1.25
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K 1 1 1
4BVN
0.04 0.11 0.26 2.80 67
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A 1 1 25
4BVN, 6IBL, 4GPO, 2YCY, 6H7L, 3ZPR, 2Y04, 6H7N, 6TKO, 3ZPQ, 2Y00, 2VT4, 2Y02, 5A8E, 2YCX, 6H7O, 2Y03, 6H7J, 4AMJ, 2Y01, 6H7M, 4AMI, 5F8U, 2YCZ, 2YCW
0.1 0.11 0 0.50 3
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48
F
M 1 1 25
4BVN, 6IBL, 4GPO, 2YCY, 6H7L, 3ZPR, 2Y04, 6H7N, 6TKO, 3ZPQ, 2Y00, 2VT4, 2Y02, 5A8E, 2YCX, 6H7O, 2Y03, 6H7J, 4AMJ, 2Y01, 6H7M, 4AMI, 5F8U, 2YCZ, 2YCW
0.05 0.24 -0.67 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L 1 1 2
4BVN, 5A8E
0.03 0.21 -1.25 Pos Match (But Not Mutant AA) Pos & Mutant AA Match 8
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C 1 1 2
4QKX, 3PDS
0.68 -0.02 70
Inactive
A (Rhodopsin)
Aminergic
Peptide
Dopamine
Apelin
APJ
DRD2
apelin
D2
TM3 3x40
I
V
A 2 2 2
5VBL, 6CM4
0.06 0 0.50 20
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K 1 1 1
5VBL
0.26 2.80 Pos Match (But Not Mutant AA) 82
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y 1 1 5
4MBS, 6AKX, 5UIW, 6AKY, 7F1T
0.08 0.53 -0.71 1 2
Active
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N 1 1 8
4MBS, 6AKX, 5UIW, 6AKY, 7F1Q, 7F1S, 7F1R, 7F1T
0.04 0.65 0.85 49
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D 1 1 5
4MBS, 6AKX, 5UIW, 6AKY, 7F1T
0.69 0.43 4 1 6
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E 1 1 5
4MBS, 6AKX, 5UIW, 6AKY, 7F1T
0.12 0.40 0.11 4 1 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A 1 1 1
5LWE
0.04 0 0.50 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A 1 1 1
5LWE
0.07 0 0.50 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A 1 1 1
5LWE
0.12 0 0.50 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C 1 1 1
5LWE
0.02 0.68 -0.02 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A 1 1 1
5LWE
0.07 0 0.50 3
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36
V
A 1 1 1
5LWE
0.01 0 0.50 6 1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A 1 1 1
5LWE
0.15 0 0.50 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A 1 1 1
5LWE
0.08 0 0.50 20
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A 1 1 4
5XRA, 5TGZ, 5U09, 5XR8
0.01 0 0.50 1
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37
E
K 1 1 3
5XRA, 5TGZ, 5XR8
0.11 0.26 2.80 8
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E 1 1 3
5XRA, 5TGZ, 5XR8
0.04 0.40 0.11 1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C 1 1 1
4RWS
0.68 -0.02 108
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36
T
P 1 1 3
3OE9, 4RWS, 3OE0
0.0 3.16 0.14 6 1 5
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y 1 1 2
5X93, 5XPR
0.09 0.53 -0.71
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A 1 1 1
5X93
0.08 0 0.50 22
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A 1 1 2
5X93, 5XPR
0.06 0 0.50 48
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A 1 1 2
5X93, 5XPR
0.1 0 0.50 31
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48
I
A 1 1 2
5X93, 5XPR
0.13 0 0.50 1
Active
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A 1 1 4
4PHU, 5TZY, 5TZR, 5KW2
0.06 0 0.50 4 1 1
Active
A (Rhodopsin)
Peptide
Lipid
Proteinase-activated
Free fatty acid
FFAR1
PAR2
PAR2
FFA1
TM3 3x34
F
G
A 2 2 6
4PHU, 5NDZ, 5NJ6, 5TZR, 5NDD, 5KW2
0.07 0 0.50 3
Active
A (Rhodopsin)
Peptide
Lipid
Neurotensin
Free fatty acid
NTR1
FFAR1
FFA1
NTS1
TM3 3x49
G
E
A 2 2 6
4PHU, 5TZY, 4XES, 5TZR, 4GRV, 5KW2
0.01 0 0.50 Pos & Mutant AA Match 2 2
Active
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM5 5x58
Y
F 1 1 4
4PHU, 5TZY, 5TZR, 5KW2
0.01 0.54 -1.71 4
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37
D
C 1 1 1
4Z36
0.68 -0.02 8
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C 1 1 1
4Z36
0.01 0.68 -0.02 32
Inactive
Intermediate
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L 1 1 22
5T04, 8FMZ, 7L0P, 4BUO, 3ZEV, 4XES, 4XEE, 4GRV, 6ZIN, 6Z4Q, 8FN0, 7L0R, 7L0Q, 4BV0, 6Z66, 6Z4V, 6Z8N, 7L0S, 6YVR, 6ZA8, 6Z4S, 4BWB
0.37 0.21 -1.25
Inactive
Active
A (Rhodopsin)
Lipid
Peptide
Leukotriene
Neurotensin
Q9WTK1
NTR1
BLT1
NTS1
ECL2
G
S
A 2 2 5
5T04, 4XES, 4XEE, 5X33, 4GRV
0 0.50
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A 1 1 4
3ZEV, 4BV0, 4BWB, 4BUO
0.01 0 0.50 4
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A 1 1 4
5T04, 4XEE, 4XES, 4GRV
0.19 0 0.50 2
Inactive
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term
D
N
C 2 1 19
6FKD, 5W0P, 5DYS, 4BEZ, 5EN0, 4BEY, 4A4M, 6FK9, 6FKC, 6FK7, 6FK6, 6FK8, 5DGY, 6FKA, 3C9M, 2J4Y, 4ZWJ, 2X72, 6FKB
0.68 -0.02
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I 1 1 2
5EN0, 5DYS
0.04 0.25 0.41 -1.12 93
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q 2 1 4
4ZWJ, 2X72, 5DGY, 5W0P
0.01 0.39 0.77 57
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y 2 1 4
4A4M, 5W0P, 5DGY, 4ZWJ
0.01 0.53 -0.71 2 1
Active
A (Rhodopsin)
Nucleotide
P2Y
P2RY1
P2Y12
P2Y1
P2Y12
TM7 7x49
D
N 2 1 6
4XNW, 4PXZ, 4PY0, 4XNV, 7PP1, 4NTJ
0.72 0.65 0.85
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A 1 1 3
5NJ6, 5NDZ, 5NDD
0.11 0 0.50
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A 1 1 3
5NJ6, 5NDZ, 5NDD
0.05 0 0.50 3 1 1
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L 1 1 3
5NJ6, 5NDZ, 5NDD
0.73 0.21 -1.25 2
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A 1 1 3
5NJ6, 5NDZ, 5NDD
0.0 0 0.50 1
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E 1 1 3
5NJ6, 5NDZ, 5NDD
0.01 0.40 0.11 5
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A 1 1 3
5NJ6, 5NDZ, 5NDD
0.12 0 0.50 1 3
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A 1 1 3
5NJ6, 5NDZ, 5NDD
0.14 0 0.50 4
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A 1 1 3
5NJ6, 5NDZ, 5NDD
0.13 0 0.50 1
Active
Other
A (Rhodopsin)
Lipid
Platelet-activating factor
PTAFR
PAF
TM6 6x34
A
D 1 1 2
5ZKQ, 5ZKP
0.69 0.43 2
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G 1 1 1
5X33
0.27 1.00 1.15 15
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G 1 1 1
5X33
0.68 1.00 1.15 7
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A 1 1 1
5X33
0.09 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A 1 1 5
8GTG, 8GTI, 4K5Y, 8GTM, 4Z9G
0 0.50 13
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A 1 1 5
8GTG, 8GTI, 4K5Y, 8GTM, 4Z9G
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A 1 1 2
4K5Y, 4Z9G
0.07 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48
S
A 1 1 2
4K5Y, 4Z9G
0.2 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A 1 1 2
4K5Y, 4Z9G
0 0.50
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLP1R
GLP-1
CRF1
ECL2 45x52
F
T
A 2 2 3
4K5Y, 5NX2, 4Z9G
0 0.50 15
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A 1 1 2
4K5Y, 4Z9G
0 0.50 6
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLR
GLP1R
GLP-1
CRF1
glucagon
TM6 6x30
K
Y
A 3 2 5
5VEW, 5VEX, 4K5Y, 5EE7, 4Z9G
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A 1 1 2
4K5Y, 4Z9G
0 0.50 3
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A 1 1 2
4K5Y, 4Z9G
0 0.50 15
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A 1 1 2
4K5Y, 4Z9G
0 0.50 Pos & Mutant AA Match 1 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x56
S
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM2 2x59
I
V
F 2 1 3
5VEW, 5EE7, 5VEX
0.54 -1.71
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
ECL1
G
T
E 2 1 2
5EE7, 5NX2
0.40 0.11
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
G
Q
A 1 1 1
5NX2
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
D
R 1 1 1
5NX2
0.21 1.81
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM3 3x24
G
S
A 2 1 3
5VEW, 5EE7, 5VEX
0.07 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F 1 1 1
5NX2
0.4 0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C 1 1 2
5VEW, 5VEX
0.68 -0.02 12
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2
L
F 1 1 1
5NX2
0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A 1 1 2
5VEW, 5VEX
0.07 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C 1 1 2
5VEW, 5VEX
0.68 -0.02 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I 1 1 2
5VEW, 5VEX
0.07 0.41 -1.12
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F 1 1 2
5VEW, 5VEX
0.07 0.54 -1.71 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A 1 1 1
5NX2
0 0.50 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A 1 1 1
5NX2
0 0.50 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C 1 1 2
5VEW, 5VEX
0.68 -0.02 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V 1 1 1
5NX2
0.61 -0.46 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A 1 1 1
5NX2
0.07 0 0.50 1 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A 1 1 1
5EE7
0.33 0 0.50 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A 1 1 2
5YQZ, 5EE7
0 0.50 1 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48
A
L 1 1 1
5EE7
0.2 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x56
S
A 1 1 1
5EE7
0.27 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A 1 1 1
5EE7
0.27 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F 1 1 1
5EE7
0.13 0.54 -1.71 6
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A 1 1 1
5EE7
0.07 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A 1 1 6
7P2L, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
0.05 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y 1 1 6
7P2L, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
0.05 0.53 -0.71
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A 1 1 6
7P2L, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
0.05 0 0.50 Pos & Mutant AA Match
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M 1 1 6
7P2L, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
0.24 -0.67
Active
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A 1 1 8
7P2L, 7FD9, 7FD8, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
0.05 0 0.50
Active
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A 1 1 8
7P2L, 7FD9, 7FD8, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
0 0.50
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F 1 1 2
5L7I, 5L7D
0.54 -1.71 1
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A 1 1 1
5WF6
0.03 0 0.50 Pos & AA Mutant Match 5
STATE TARGETS MUTATIONS FREQUENCY DATA (WILD TYPE) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Active
Inactive
A (Rhodopsin)
Protein
Aminergic
Dopamine
Chemokine
5-Hydroxytryptamine
5HT1B
CXCR4
DRD3
5-HT1B
CXCR4
D3
TM3 3x41 L
W
3 3 13
3OE8, 3ODU, 9F34, 3OE0, 9F33, 3OE9, 4IAR, 3OE6, 4IAQ, 5V54, 7C61, 4RWS, 3PBL
0.32 0.21 -1.25 8
Intermediate
Active
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2B
5-HT2B
TM3 3x41 M
W
1 1 8
6DRX, 6DRZ, 4IB4, 5TVN, 4NC3, 5TUD, 6DS0, 6DRY
0.04 0.24 -0.67 8
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45 C
N
1 1 2
6BQH, 6BQG
0.01 0.68 -0.02 Pos & Wild Type AA Match 5
Active
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM2 2x52 A
L
2 1 28
5IUB, 5N2S, 5NM4, 3PWH, 5OLO, 4UG2, 3UZA, 5MZP, 5OLZ, 5IU7, 2YDO, 3REY, 4UHR, 2YDV, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 5OM1, 3UZC, 5OM4, 5N2R, 5NM2, 5OLG, 3RFM
0.06 0 0.50 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A1
A2A
TM3 3x36 T
A
2 1 24
5IUB, 5N2S, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
0.05 0.66 0.25 115
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM5 5x63 Y
A
1 1 1
5N2S
0.03 0.53 -0.71
Active
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Peptide
Dopamine
Adenosine
Neurotensin
NTR1
AA2AR
DRD2
AA1R
A1
A2A
D2
NTS1
TM6 6x37 L
A
4 3 26
5IUB, 5N2S, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 4GRV, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 6CM4, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
0.38 0.21 -1.25 7 1 4
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Dopamine
Adenosine
DRD2
AA1R
A1
D2
TM6 6x41 L
A
2 2 2
5N2S, 6CM4
0.18 0.21 -1.25 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM7 7x41 T
A
1 1 1
5N2S
0.07 0.66 0.25 62
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46 L
A
1 1 4
4UHR, 2YDV, 4UG2, 2YDO
0.9 0.21 -1.25
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50 D
N
1 1 1
5WF5
0.92 0.69 0.43 Pos & Wild Type AA Match 3
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62 T
A
1 1 4
4UHR, 2YDV, 4UG2, 2YDO
0.1 0.66 0.25 6
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37 Q
A
1 1 4
4UHR, 2YDV, 4UG2, 2YDO
0.02 0.39 0.77 67
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55 R
A
1 1 23
5IUB, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
0.04 0.21 1.81 1 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43 K
A
1 1 23
5IUB, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
0.16 0.26 2.80 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM5 5x63 L
A
1 1 23
5IUB, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
0.14 0.21 -1.25
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM6 6x41 V
A
1 1 23
5IUB, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
0.41 0.61 -0.46 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM7 7x41 S
A
1 1 23
5IUB, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
0.16 0.50 0.46 62
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59 R
S
1 1 24
4BVN, 6IBL, 4GPO, 2YCY, 6H7L, 3ZPR, 2Y04, 6H7N, 3ZPQ, 2Y00, 2VT4, 2Y02, 5A8E, 2YCX, 6H7O, 2Y03, 6H7J, 4AMJ, 2Y01, 6H7M, 4AMI, 5F8U, 2YCZ, 2YCW
0.24 0.21 1.81
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53 M
V
1 1 25
4BVN, 6IBL, 4GPO, 2YCY, 6H7L, 3ZPR, 2Y04, 6H7N, 6TKO, 3ZPQ, 2Y00, 2VT4, 2Y02, 5A8E, 2YCX, 6H7O, 2Y03, 6H7J, 4AMJ, 2Y01, 6H7M, 4AMI, 5F8U, 2YCZ, 2YCW
0.07 0.33 0.24 -0.67 23
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
Dopamine
ADRB1
DRD2
D2
β1
TM3 3x40 I
A
V
2 2 3
4BVN, 5A8E, 6CM4
0.4 0.41 -1.12 20
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
ADRB2
β2
β1
TM3 3x41 E
W
2 1 5
3NY9, 3D4S, 3NYA, 3NY8, 5A8E
0.01 0.33 0.40 0.11 8
Active
Inactive
A (Rhodopsin)
Aminergic
Lipid
Adrenoceptors
Free fatty acid
ADRB1
FFAR1
β1
FFA1
TM5 5x58 Y
F
A
2 2 22
5TZY, 4BVN, 4GPO, 2YCY, 3ZPR, 2Y04, 3ZPQ, 2Y00, 2VT4, 2Y02, 5A8E, 2YCX, 4PHU, 5KW2, 2Y03, 4AMJ, 2Y01, 5TZR, 4AMI, 5F8U, 2YCZ, 2YCW
0.74 0.53 -0.71 4
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27 A
L
1 1 18
4BVN, 2Y03, 5F8U, 4AMJ, 4GPO, 2YCY, 5A8E, 4AMI, 2Y04, 3ZPR, 2VT4, 2Y01, 3ZPQ, 2Y00, 2Y02, 2YCX, 2YCZ, 2YCW
0.08 0.11 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31 D
K
1 1 1
4BVN
0.1 0.22 0.69 0.43 67
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36 F
A
1 1 25
4BVN, 6IBL, 4GPO, 2YCY, 6H7L, 3ZPR, 2Y04, 6H7N, 6TKO, 3ZPQ, 2Y00, 2VT4, 2Y02, 5A8E, 2YCX, 6H7O, 2Y03, 6H7J, 4AMJ, 2Y01, 6H7M, 4AMI, 5F8U, 2YCZ, 2YCW
0.14 0.44 0.54 -1.71 3
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48 F
M
1 1 25
4BVN, 6IBL, 4GPO, 2YCY, 6H7L, 3ZPR, 2Y04, 6H7N, 6TKO, 3ZPQ, 2Y00, 2VT4, 2Y02, 5A8E, 2YCX, 6H7O, 2Y03, 6H7J, 4AMJ, 2Y01, 6H7M, 4AMI, 5F8U, 2YCZ, 2YCW
0.06 0.33 0.54 -1.71 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53 Y
L
1 1 2
4BVN, 5A8E
0.89 1.0 0.53 -0.71 Pos & Wild Type AA Match Pos & Wild Type AA Match 8
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63 H
C
1 1 2
4QKX, 3PDS
0.03 0.11 0.61 0.11 70
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM3 3x40 V
A
1 1 1
5VBL
0.24 0.61 -0.46 20
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48 W
K
1 1 1
5VBL
0.68 0.49 -2.09 Pos & Wild Type AA Match 82
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60 C
Y
1 1 5
4MBS, 6AKX, 5UIW, 6AKY, 7F1T
0.02 0.68 -0.02 1 2
Active
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61 G
N
1 1 8
4MBS, 6AKX, 5UIW, 6AKY, 7F1Q, 7F1S, 7F1R, 7F1T
0.02 1.00 1.15 49
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33 A
D
1 1 5
4MBS, 6AKX, 5UIW, 6AKY, 7F1T
0.28 0 0.50 4 1 6
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49 K
E
1 1 5
4MBS, 6AKX, 5UIW, 6AKY, 7F1T
0.13 0.26 2.80 4 1 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48 T
A
1 1 1
5LWE
0.05 0.66 0.25 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50 V
A
1 1 1
5LWE
0.03 0.61 -0.46 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38 M
A
1 1 1
5LWE
0.04 0.24 -0.67 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47 S
C
1 1 1
5LWE
0.55 0.50 0.46 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41 T
A
1 1 1
5LWE
0.09 0.66 0.25 3
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36 V
A
1 1 1
5LWE
0.15 0.61 -0.46 6 1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29 N
A
1 1 1
5LWE
0.03 0.65 0.85 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39 T
A
1 1 1
5LWE
0.03 0.66 0.25 20
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46 T
A
1 1 4
5XRA, 5TGZ, 5U09, 5XR8
0.01 0.66 0.25 1
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37 E
K
1 1 3
5XRA, 5TGZ, 5XR8
0.04 0.40 0.11 8
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32 R
E
1 1 3
5XRA, 5TGZ, 5XR8
0.32 0.21 1.81 1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51 D
C
1 1 1
4RWS
0.03 0.69 0.43 108
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36 T
P
1 1 3
3OE9, 4RWS, 3OE0
0.25 0.66 0.25 6 1 5
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55 R
Y
1 1 2
5X93, 5XPR
0.02 0.21 1.81
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56 D
A
1 1 1
5X93
0.01 0.69 0.43 22
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36 K
A
1 1 2
5X93, 5XPR
0.05 0.26 2.80 48
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54 S
A
1 1 2
5X93, 5XPR
0.05 0.50 0.46 31
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48 I
A
1 1 2
5X93, 5XPR
0.15 0.41 -1.12 1
Active
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40 L
A
1 1 4
4PHU, 5TZY, 5TZR, 5KW2
0.03 0.21 -1.25 4 1 1
Active
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x34 F
A
1 1 3
4PHU, 5TZR, 5KW2
0.11 0.54 -1.71 3
Active
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x49 G
A
1 1 4
4PHU, 5TZY, 5TZR, 5KW2
0.01 1.00 1.15 Pos & Wild Type AA Match 2 2
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37 D
C
1 1 1
4Z36
0.01 0.69 0.43 8
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59 V
C
1 1 1
4Z36
0.12 0.61 -0.46 32
Inactive
A (Rhodopsin)
Peptide
Neuropeptide Y
NPY1R
Y1
TM3 3x41 F
W
1 1 2
5ZBQ, 5ZBH
0.28 0.54 -1.71 8
Inactive
Intermediate
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54 A
L
1 1 22
5T04, 8FMZ, 7L0P, 4BUO, 3ZEV, 4XES, 4XEE, 4GRV, 6ZIN, 6Z4Q, 8FN0, 7L0R, 7L0Q, 4BV0, 6Z66, 6Z4V, 6Z8N, 7L0S, 6YVR, 6ZA8, 6Z4S, 4BWB
0.04 0 0.50
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM3 3x49 E
A
1 1 2
4GRV, 4XES
0.21 0.40 0.11 Pos & Wild Type AA Match 2 2
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
ECL2 G
A
1 1 4
5T04, 4XEE, 4XES, 4GRV
1.00 1.15
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54 I
A
1 1 4
3ZEV, 4BV0, 4BWB, 4BUO
0.33 0.41 -1.12 4
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43 V
A
1 1 4
5T04, 4XEE, 4XES, 4GRV
0.1 0.61 -0.46 2
Inactive
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term N
C
2 1 19
6FKD, 5W0P, 5DYS, 4BEZ, 5EN0, 4BEY, 4A4M, 6FK9, 6FKC, 6FK7, 6FK6, 6FK8, 5DGY, 6FKA, 3C9M, 2J4Y, 4ZWJ, 2X72, 6FKB
0.65 0.85
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60 T
I
1 1 2
5EN0, 5DYS
0.08 0.38 0.66 0.25 93
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28 E
Q
2 1 4
4ZWJ, 2X72, 5DGY, 5W0P
0.02 0.5 0.40 0.11 57
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40 M
Y
2 1 4
4A4M, 5W0P, 5DGY, 4ZWJ
0.05 0.75 0.24 -0.67 2 1
Inactive
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
ECL3 D
C
1 1 16
6FKD, 5DYS, 4BEZ, 5EN0, 4BEY, 4A4M, 6FK9, 6FKC, 6FK7, 6FK6, 6FK8, 6FKA, 3C9M, 2J4Y, 2X72, 6FKB
0.69 0.43
Active
A (Rhodopsin)
Nucleotide
P2Y
P2RY1
P2Y12
P2Y1
P2Y12
TM7 7x49 D
N
2 1 6
4XNW, 4PXZ, 4PY0, 4XNV, 7PP1, 4NTJ
0.2 0.69 0.43
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46 G
A
1 1 3
5NJ6, 5NDZ, 5NDD
0.54 1.00 1.15
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37 H
A
1 1 3
5NJ6, 5NDZ, 5NDD
0.03 0.61 0.11 3 1 1
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x34 G
A
1 1 3
5NJ6, 5NDZ, 5NDD
0.02 1.00 1.15 3
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43 M
L
1 1 3
5NJ6, 5NDZ, 5NDD
0.05 0.24 -0.67 2
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51 Y
A
1 1 3
5NJ6, 5NDZ, 5NDD
0.66 0.53 -0.71 1
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53 V
E
1 1 3
5NJ6, 5NDZ, 5NDD
0.07 0.61 -0.46 5
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64 M
A
1 1 3
5NJ6, 5NDZ, 5NDD
0.01 0.24 -0.67 1 3
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38 I
A
1 1 3
5NJ6, 5NDZ, 5NDD
0.08 0.41 -1.12 4
Active
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42 L
A
1 1 3
5NJ6, 5NDZ, 5NDD
0.25 0.21 -1.25 1
Active
Other
A (Rhodopsin)
Lipid
Platelet-activating factor
PTAFR
PAF
TM6 6x34 A
D
1 1 2
5ZKQ, 5ZKP
0.24 0 0.50 2
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67 H
G
1 1 1
5X33
0.07 0.61 0.11 15
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21 K
G
1 1 1
5X33
0.01 0.26 2.80 7
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67 V
A
1 1 1
5X33
0.03 0.61 -0.46 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
C-term S
A
1 1 1
5X33
0.50 0.46
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36 V
A
1 1 5
8GTG, 8GTI, 4K5Y, 8GTM, 4Z9G
0.07 0.61 -0.46 13
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60 L
A
1 1 5
8GTG, 8GTI, 4K5Y, 8GTM, 4Z9G
0.33 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44 W
A
1 1 2
4K5Y, 4Z9G
0.13 0.49 -2.09
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48 S
A
1 1 2
4K5Y, 4Z9G
0.07 0.50 0.46
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43 K
A
1 1 2
4K5Y, 4Z9G
0.13 0.26 2.80
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
ECL2 45x52 F
A
1 1 2
4K5Y, 4Z9G
0.13 0.54 -1.71 15
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48 I
A
1 1 2
4K5Y, 4Z9G
0.2 0.41 -1.12 6
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x30 Y
A
1 1 2
4K5Y, 4Z9G
0.73 0.53 -0.71
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51 F
A
1 1 2
4K5Y, 4Z9G
0.93 0.54 -1.71 3
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38 S
A
1 1 2
4K5Y, 4Z9G
0.13 0.50 0.46 15
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53 Y
A
1 1 2
4K5Y, 4Z9G
0.93 0.53 -0.71 Pos & Wild Type AA Match 1 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM2 2x56 S
A
C
2 1 3
5VEW, 5EE7, 5VEX
0.47 0.50 0.46
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x59 I
F
1 1 2
5VEW, 5VEX
0.4 0.41 -1.12
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 T
E
1 1 1
5NX2
0.66 0.25
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 Q
A
1 1 1
5NX2
0.39 0.77
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 D
R
1 1 1
5NX2
0.69 0.43
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x24 S
A
1 1 2
5VEW, 5VEX
0.27 0.50 0.46
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31 L
F
1 1 1
5NX2
0.2 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32 M
C
1 1 2
5VEW, 5VEX
0.13 0.24 -0.67 12
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2 L
F
1 1 1
5NX2
0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48 S
A
1 1 2
5VEW, 5VEX
0.07 0.50 0.46
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
ECL2 G
E
A
2 1 2
5EE7, 5NX2
1.00 1.15
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL2 45x52 T
A
1 1 1
5NX2
0.2 0.66 0.25 15
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51 I
C
1 1 2
5VEW, 5VEX
0.6 0.41 -1.12 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52 G
I
1 1 2
5VEW, 5VEX
0.2 1.00 1.15
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63 C
A
1 1 1
5NX2
0.07 0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
GLP-1
glucagon
TM6 6x30 K
A
2 1 3
5VEW, 5EE7, 5VEX
0.2 0.26 2.80
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31 C
F
1 1 2
5VEW, 5VEX
0.07 0.68 -0.02 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42 P
A
1 1 1
5NX2
0.93 3.16 0.14 2
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45 G
A
C
1 1 3
5VEW, 5VEX, 5NX2
1.0 1.00 1.15 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47 H
V
1 1 1
5NX2
0.73 0.61 0.11 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56 V
A
1 1 1
5NX2
0.07 0.61 -0.46 1 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48 G
A
1 1 1
5EE7
0.13 1.00 1.15 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39 R
A
1 1 2
5YQZ, 5EE7
1.0 0.21 1.81 1 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48 A
L
1 1 1
5EE7
0.2 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x59 V
F
1 1 1
5EE7
0.4 0.61 -0.46
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM3 3x24 G
A
1 1 1
5EE7
0.4 1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54 M
A
1 1 1
5EE7
0.07 0.24 -0.67
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48 E
F
1 1 1
5EE7
0.27 0.40 0.11 6
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39 F
A
1 1 1
5EE7
0.33 0.54 -1.71
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35 E
A
1 1 6
7P2L, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
0.09 0.40 0.11
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48 N
Y
1 1 6
7P2L, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
0.41 0.65 0.85
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50 I
A
1 1 6
7P2L, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
0.45 0.41 -1.12 Pos & Wild Type AA Match
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2 G
M
1 1 6
7P2L, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
1.00 1.15
Active
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42 T
A
1 1 8
7P2L, 7FD9, 7FD8, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
0.09 0.66 0.25
Active
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53 S
A
1 1 8
7P2L, 7FD9, 7FD8, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
0.14 0.50 0.46
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40 V
F
1 1 2
5L7I, 5L7D
0.09 0.09 0.61 -0.46 1
Active
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39 S
A
1 1 1
5WF6
0.72 0.50 0.46 Pos & Wild Type AA Match 5
STATE TARGETS MUTATIONS FREQUENCY DATA (FOLD CHANGE (MUTANT/WILD TYPE)) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Active
Inactive
A (Rhodopsin) Protein Aminergic Dopamine Chemokine 5-Hydroxytryptamine 5HT1B CXCR4 DRD3 5-HT1B CXCR4 D3 TM3 3x41 L W 3 3 13
3OE8, 3ODU, 9F34, 3OE0, 9F33, 3OE9, 4IAR, 3OE6, 4IAQ, 5V54, 7C61, 4RWS, 3PBL
-0.29 (0.03−0.32) 0.28 (0.49−0.21) -0.84 (-2.09−-1.25) 8
Intermediate
Active
A (Rhodopsin) Aminergic 5-Hydroxytryptamine 5HT2B 5-HT2B TM3 3x41 M W 1 1 8
6DRX, 6DRZ, 4IB4, 5TVN, 4NC3, 5TUD, 6DS0, 6DRY
-0.01 (0.03−0.04) 0 (0−0) 0.25 (0.49−0.24) -1.42 (-2.09−-0.67) 8
Active
Inactive
A (Rhodopsin) Aminergic 5-Hydroxytryptamine 5HT2C 5-HT2C TM7 7x45 C N 1 1 2
6BQH, 6BQG
0.66 (0.67−0.01) 0 (0−0) -0.03 (0.65−0.68) 0.87 (0.85−-0.02) Added 5
Active
Inactive
A (Rhodopsin) Nucleotide Adenosine AA2AR AA1R A1 A2A TM2 2x52 A L 2 1 28
5IUB, 5N2S, 5NM4, 3PWH, 5OLO, 4UG2, 3UZA, 5MZP, 5OLZ, 5IU7, 2YDO, 3REY, 4UHR, 2YDV, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 5OM1, 3UZC, 5OM4, 5N2R, 5NM2, 5OLG, 3RFM
0.57 (0.63−0.06) 0 (0−0) 0.21 (0.21−0) -1.75 (-1.25−0.50) 2
Inactive
A (Rhodopsin) Nucleotide Adenosine AA2AR AA1R A1 A2A TM3 3x36 T A 2 1 24
5IUB, 5N2S, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
-0.03 (0.02−0.05) 0 (0−0) -0.66 (0−0.66) 0.25 (0.50−0.25) 115
Inactive
A (Rhodopsin) Nucleotide Adenosine AA1R A1 TM5 5x63 Y A 1 1 1
5N2S
0.02 (0.05−0.03) 0 (0−0) -0.53 (0−0.53) 1.21 (0.50−-0.71)
Active
Inactive
A (Rhodopsin) Nucleotide Aminergic Peptide Dopamine Adenosine Neurotensin NTR1 AA2AR DRD2 AA1R A1 A2A D2 NTS1 TM6 6x37 L A 4 3 26
5IUB, 5N2S, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 4GRV, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 6CM4, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
-0.34 (0.04−0.38) -0.21 (0−0.21) 1.75 (0.50−-1.25) 7 1 4
Inactive
A (Rhodopsin) Nucleotide Aminergic Dopamine Adenosine DRD2 AA1R A1 D2 TM6 6x41 L A 2 2 2
5N2S, 6CM4
-0.13 (0.05−0.18) -0.21 (0−0.21) 1.75 (0.50−-1.25) 2
Inactive
A (Rhodopsin) Nucleotide Adenosine AA1R A1 TM7 7x41 T A 1 1 1
5N2S
0.31 (0.38−0.07) 0 (0−0) -0.66 (0−0.66) 0.25 (0.50−0.25) 62
Active
A (Rhodopsin) Nucleotide Adenosine AA2AR A2A TM2 2x46 L A 1 1 4
4UHR, 2YDV, 4UG2, 2YDO
-0.9 (0−0.9) 0 (0−0) -0.21 (0−0.21) 1.75 (0.50−-1.25)
Active
A (Rhodopsin) Nucleotide Adenosine AA2AR A2A TM2 2x50 D N 1 1 1
5WF5
-0.89 (0.03−0.92) 0 (0−0) -0.04 (0.65−0.69) 0.42 (0.85−0.43) Removed 3
Active
A (Rhodopsin) Nucleotide Adenosine AA2AR A2A TM2 2x62 T A 1 1 4
4UHR, 2YDV, 4UG2, 2YDO
0.02 (0.12−0.1) 0 (0−0) -0.66 (0−0.66) 0.25 (0.50−0.25) 6
Active
A (Rhodopsin) Nucleotide Adenosine AA2AR A2A TM3 3x37 Q A 1 1 4
4UHR, 2YDV, 4UG2, 2YDO
0.01 (0.03−0.02) 0 (0−0) -0.39 (0−0.39) -0.27 (0.50−0.77) 67
Inactive
A (Rhodopsin) Nucleotide Adenosine AA2AR A2A TM3 3x55 R A 1 1 23
5IUB, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
0.04 (0.08−0.04) 0 (0−0) -0.21 (0−0.21) -1.31 (0.50−1.81) 1 2
Inactive
A (Rhodopsin) Nucleotide Adenosine AA2AR A2A TM4 4x43 K A 1 1 23
5IUB, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
-0.03 (0.13−0.16) 0 (0−0) -0.26 (0−0.26) -2.30 (0.50−2.80) 1
Inactive
A (Rhodopsin) Nucleotide Adenosine AA2AR A2A TM5 5x63 L A 1 1 23
5IUB, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
-0.09 (0.05−0.14) 0 (0−0) -0.21 (0−0.21) 1.75 (0.50−-1.25)
Inactive
A (Rhodopsin) Nucleotide Adenosine AA2AR A2A TM6 6x41 V A 1 1 23
5IUB, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
-0.36 (0.05−0.41) 0 (0−0) -0.61 (0−0.61) 0.96 (0.50−-0.46) 2
Inactive
A (Rhodopsin) Nucleotide Adenosine AA2AR A2A TM7 7x41 S A 1 1 23
5IUB, 5NM4, 3PWH, 5NM2, 5OLO, 3RFM, 3UZA, 5MZP, 5OLZ, 5IU7, 3REY, 5OLH, 5IU4, 5NLX, 5IUA, 5IU8, 5MZJ, 5OLV, 3UZC, 5OM4, 5N2R, 5OM1, 5OLG
0.22 (0.38−0.16) 0 (0−0) -0.50 (0−0.50) 0.04 (0.50−0.46) 62
Active
Inactive
A (Rhodopsin) Aminergic Adrenoceptors ADRB1 β1 TM1 1x59 R S 1 1 24
4BVN, 6IBL, 4GPO, 2YCY, 6H7L, 3ZPR, 2Y04, 6H7N, 3ZPQ, 2Y00, 2VT4, 2Y02, 5A8E, 2YCX, 6H7O, 2Y03, 6H7J, 4AMJ, 2Y01, 6H7M, 4AMI, 5F8U, 2YCZ, 2YCW
-0.2 (0.04−0.24) 0 (0−0) 0.29 (0.50−0.21) -1.35 (0.46−1.81)
Active
Inactive
A (Rhodopsin) Aminergic Adrenoceptors ADRB1 β1 TM2 2x53 M V 1 1 25
4BVN, 6IBL, 4GPO, 2YCY, 6H7L, 3ZPR, 2Y04, 6H7N, 6TKO, 3ZPQ, 2Y00, 2VT4, 2Y02, 5A8E, 2YCX, 6H7O, 2Y03, 6H7J, 4AMJ, 2Y01, 6H7M, 4AMI, 5F8U, 2YCZ, 2YCW
0.16 (0.23−0.07) 0.0 (0.33−0.33) 0.37 (0.61−0.24) 0.21 (-0.46−-0.67) 23
Inactive
A (Rhodopsin) Aminergic Adrenoceptors ADRB1 β1 TM3 3x40 I V 1 1 2
4BVN, 5A8E
-0.16 (0.24−0.4) -1.0 (0−1.0) 0.20 (0.61−0.41) 0.66 (-0.46−-1.12) 20
Inactive
A (Rhodopsin) Aminergic Adrenoceptors ADRB1 ADRB2 β2 β1 TM3 3x41 E W 2 1 5
3NY9, 3D4S, 3NYA, 3NY8, 5A8E
0.02 (0.03−0.01) -0.33 (0−0.33) 0.09 (0.49−0.40) -2.20 (-2.09−0.11) 8
Inactive
A (Rhodopsin) Aminergic Adrenoceptors ADRB1 β1 TM5 5x58 Y A 1 1 18
4BVN, 2Y03, 5F8U, 4AMJ, 4GPO, 2YCY, 5A8E, 4AMI, 2Y04, 3ZPR, 2VT4, 2Y01, 3ZPQ, 2Y00, 2Y02, 2YCX, 2YCZ, 2YCW
-0.72 (0.02−0.74) -1.0 (0−1.0) -0.53 (0−0.53) 1.21 (0.50−-0.71) 4
Inactive
A (Rhodopsin) Aminergic Adrenoceptors ADRB1 β1 TM6 6x27 A L 1 1 18
4BVN, 2Y03, 5F8U, 4AMJ, 4GPO, 2YCY, 5A8E, 4AMI, 2Y04, 3ZPR, 2VT4, 2Y01, 3ZPQ, 2Y00, 2Y02, 2YCX, 2YCZ, 2YCW
0.03 (0.11−0.08) 0.0 (0.11−0.11) 0.21 (0.21−0) -1.75 (-1.25−0.50)
Inactive
A (Rhodopsin) Aminergic Adrenoceptors ADRB1 β1 TM7 7x31 D K 1 1 1
4BVN
-0.06 (0.04−0.1) -0.11 (0.11−0.22) -0.43 (0.26−0.69) 2.37 (2.80−0.43) 67
Active
Inactive
A (Rhodopsin) Aminergic Adrenoceptors ADRB1 β1 TM7 7x36 F A 1 1 25
4BVN, 6IBL, 4GPO, 2YCY, 6H7L, 3ZPR, 2Y04, 6H7N, 6TKO, 3ZPQ, 2Y00, 2VT4, 2Y02, 5A8E, 2YCX, 6H7O, 2Y03, 6H7J, 4AMJ, 2Y01, 6H7M, 4AMI, 5F8U, 2YCZ, 2YCW
-0.04 (0.1−0.14) -0.33 (0.11−0.44) -0.54 (0−0.54) 2.21 (0.50−-1.71) 3
Active
Inactive
A (Rhodopsin) Aminergic Adrenoceptors ADRB1 β1 TM7 7x48 F M 1 1 25
4BVN, 6IBL, 4GPO, 2YCY, 6H7L, 3ZPR, 2Y04, 6H7N, 6TKO, 3ZPQ, 2Y00, 2VT4, 2Y02, 5A8E, 2YCX, 6H7O, 2Y03, 6H7J, 4AMJ, 2Y01, 6H7M, 4AMI, 5F8U, 2YCZ, 2YCW
-0.01 (0.05−0.06) -0.33 (0−0.33) -0.30 (0.24−0.54) 1.04 (-0.67−-1.71) 1
Inactive
A (Rhodopsin) Aminergic Adrenoceptors ADRB1 β1 TM7 7x53 Y L 1 1 2
4BVN, 5A8E
-0.86 (0.03−0.89) -1.0 (0−1.0) -0.32 (0.21−0.53) -0.54 (-1.25−-0.71) Removed 8
Inactive
Active
A (Rhodopsin) Aminergic Adrenoceptors ADRB2 β2 TM2 2x63 H C 1 1 2
4QKX, 3PDS
-0.03 (0−0.03) -0.11 (0−0.11) 0.07 (0.68−0.61) -0.13 (-0.02−0.11) 70
Inactive
A (Rhodopsin) Peptide Apelin APJ apelin TM3 3x40 V A 1 1 1
5VBL
-0.18 (0.06−0.24) 0 (0−0) -0.61 (0−0.61) 0.96 (0.50−-0.46) 20
Inactive
A (Rhodopsin) Peptide Apelin APJ apelin TM6 6x48 W K 1 1 1
5VBL
-0.68 (0−0.68) 0 (0−0) -0.23 (0.26−0.49) 4.89 (2.80−-2.09) 82
Inactive
A (Rhodopsin) Protein Chemokine CCR5 CCR5 TM1 1x60 C Y 1 1 5
4MBS, 6AKX, 5UIW, 6AKY, 7F1T
0.06 (0.08−0.02) 0 (0−0) -0.15 (0.53−0.68) -0.69 (-0.71−-0.02) 1 2
Active
Inactive
A (Rhodopsin) Protein Chemokine CCR5 CCR5 TM4 4x61 G N 1 1 8
4MBS, 6AKX, 5UIW, 6AKY, 7F1Q, 7F1S, 7F1R, 7F1T
0.02 (0.04−0.02) 0 (0−0) -0.35 (0.65−1.00) -0.30 (0.85−1.15) 49
Inactive
A (Rhodopsin) Protein Chemokine CCR5 CCR5 TM6 6x33 A D 1 1 5
4MBS, 6AKX, 5UIW, 6AKY, 7F1T
-0.28 (0−0.28) 0 (0−0) 0.69 (0.69−0) -0.07 (0.43−0.50) 4 1 6
Inactive
A (Rhodopsin) Protein Chemokine CCR5 CCR5 H8 8x49 K E 1 1 5
4MBS, 6AKX, 5UIW, 6AKY, 7F1T
-0.01 (0.12−0.13) 0 (0−0) 0.14 (0.40−0.26) -2.69 (0.11−2.80) 4 1 2
Inactive
A (Rhodopsin) Protein Chemokine CCR9 CCR9 ICL1 12x48 T A 1 1 1
5LWE
-0.01 (0.04−0.05) 0 (0−0) -0.66 (0−0.66) 0.25 (0.50−0.25) 4
Inactive
A (Rhodopsin) Protein Chemokine CCR9 CCR9 ICL1 12x50 V A 1 1 1
5LWE
0.04 (0.07−0.03) 0 (0−0) -0.61 (0−0.61) 0.96 (0.50−-0.46) 2
Inactive
A (Rhodopsin) Protein Chemokine CCR9 CCR9 TM2 2x38 M A 1 1 1
5LWE
0.08 (0.12−0.04) 0 (0−0) -0.24 (0−0.24) 1.17 (0.50−-0.67) 1
Inactive
A (Rhodopsin) Protein Chemokine CCR9 CCR9 TM3 3x47 S C 1 1 1
5LWE
-0.53 (0.02−0.55) 0 (0−0) 0.18 (0.68−0.50) -0.48 (-0.02−0.46) 1
Inactive
A (Rhodopsin) Protein Chemokine CCR9 CCR9 TM5 5x41 T A 1 1 1
5LWE
-0.02 (0.07−0.09) 0 (0−0) -0.66 (0−0.66) 0.25 (0.50−0.25) 3
Inactive
A (Rhodopsin) Protein Chemokine CCR9 CCR9 TM6 6x36 V A 1 1 1
5LWE
-0.14 (0.01−0.15) 0 (0−0) -0.61 (0−0.61) 0.96 (0.50−-0.46) 6 1 5
Inactive
A (Rhodopsin) Protein Chemokine CCR9 CCR9 TM7 7x29 N A 1 1 1
5LWE
0.12 (0.15−0.03) 0 (0−0) -0.65 (0−0.65) -0.35 (0.50−0.85) 2
Inactive
A (Rhodopsin) Protein Chemokine CCR9 CCR9 TM7 7x39 T A 1 1 1
5LWE
0.05 (0.08−0.03) 0 (0−0) -0.66 (0−0.66) 0.25 (0.50−0.25) 20
Active
Inactive
A (Rhodopsin) Lipid Cannabinoid CNR1 CB1 TM3 3x46 T A 1 1 4
5XRA, 5TGZ, 5U09, 5XR8
0.0 (0.01−0.01) 0 (0−0) -0.66 (0−0.66) 0.25 (0.50−0.25) 1
Active
Inactive
A (Rhodopsin) Lipid Cannabinoid CNR1 CB1 TM5 5x37 E K 1 1 3
5XRA, 5TGZ, 5XR8
0.07 (0.11−0.04) 0 (0−0) -0.14 (0.26−0.40) 2.69 (2.80−0.11) 8
Active
Inactive
A (Rhodopsin) Lipid Cannabinoid CNR1 CB1 TM6 6x32 R E 1 1 3
5XRA, 5TGZ, 5XR8
-0.28 (0.04−0.32) 0 (0−0) 0.19 (0.40−0.21) -1.70 (0.11−1.81) 1 5
Inactive
A (Rhodopsin) Protein Chemokine CXCR4 CXCR4 ECL2 45x51 D C 1 1 1
4RWS
-0.03 (0−0.03) 0 (0−0) -0.01 (0.68−0.69) -0.45 (-0.02−0.43) 108
Inactive
A (Rhodopsin) Protein Chemokine CXCR4 CXCR4 TM6 6x36 T P 1 1 3
3OE9, 4RWS, 3OE0
-0.25 (0.0−0.25) 0 (0−0) 2.50 (3.16−0.66) -0.11 (0.14−0.25) 6 1 5
Inactive
A (Rhodopsin) Aminergic Dopamine DRD2 D2 TM3 3x40 I A 1 1 1
6CM4
-0.34 (0.06−0.4) 0 (0−0) -0.41 (0−0.41) 1.62 (0.50−-1.12) 20
Inactive
A (Rhodopsin) Peptide Endothelin EDNRB ETB TM1 1x55 R Y 1 1 2
5X93, 5XPR
0.07 (0.09−0.02) 0 (0−0) 0.32 (0.53−0.21) -2.52 (-0.71−1.81)
Inactive
A (Rhodopsin) Peptide Endothelin EDNRB ETB TM2 2x56 D A 1 1 1
5X93
0.07 (0.08−0.01) 0 (0−0) -0.69 (0−0.69) 0.07 (0.50−0.43) 22
Inactive
A (Rhodopsin) Peptide Endothelin EDNRB ETB TM5 5x36 K A 1 1 2
5X93, 5XPR
0.01 (0.06−0.05) 0 (0−0) -0.26 (0−0.26) -2.30 (0.50−2.80) 48
Inactive
A (Rhodopsin) Peptide Endothelin EDNRB ETB TM6 6x54 S A 1 1 2
5X93, 5XPR
0.05 (0.1−0.05) 0 (0−0) -0.50 (0−0.50) 0.04 (0.50−0.46) 31
Inactive
A (Rhodopsin) Peptide Endothelin EDNRB ETB TM7 7x48 I A 1 1 2
5X93, 5XPR
-0.02 (0.13−0.15) 0 (0−0) -0.41 (0−0.41) 1.62 (0.50−-1.12) 1
Active
A (Rhodopsin) Lipid Free fatty acid FFAR1 FFA1 TM2 2x40 L A 1 1 4
4PHU, 5TZY, 5TZR, 5KW2
0.03 (0.06−0.03) 0 (0−0) -0.21 (0−0.21) 1.75 (0.50−-1.25) 4 1 1
Active
A (Rhodopsin) Lipid Free fatty acid FFAR1 FFA1 TM3 3x34 F A 1 1 3
4PHU, 5TZR, 5KW2
-0.04 (0.07−0.11) 0 (0−0) -0.54 (0−0.54) 2.21 (0.50−-1.71) 3
Active
A (Rhodopsin) Lipid Free fatty acid FFAR1 FFA1 TM3 3x49 G A 1 1 4
4PHU, 5TZY, 5TZR, 5KW2
0.0 (0.01−0.01) 0 (0−0) -1.00 (0−1.00) -0.65 (0.50−1.15) 2 2
Active
A (Rhodopsin) Lipid Free fatty acid FFAR1 FFA1 TM5 5x58 Y F 1 1 4
4PHU, 5TZY, 5TZR, 5KW2
-0.73 (0.01−0.74) 0 (0−0) 0.01 (0.54−0.53) -1.00 (-1.71−-0.71) 4
Inactive
A (Rhodopsin) Lipid Lysophospholipid (LPA) LPAR1 LPA1 TM5 5x37 D C 1 1 1
4Z36
-0.01 (0−0.01) 0 (0−0) -0.01 (0.68−0.69) -0.45 (-0.02−0.43) 8
Inactive
A (Rhodopsin) Lipid Lysophospholipid (LPA) LPAR1 LPA1 TM6 6x59 V C 1 1 1
4Z36
-0.11 (0.01−0.12) 0 (0−0) 0.07 (0.68−0.61) 0.44 (-0.02−-0.46) 32
Inactive
A (Rhodopsin) Peptide Neuropeptide Y NPY1R Y1 TM3 3x41 F W 1 1 2
5ZBQ, 5ZBH
-0.25 (0.03−0.28) 0 (0−0) -0.05 (0.49−0.54) -0.38 (-2.09−-1.71) 8
Inactive
Intermediate
Active
A (Rhodopsin) Peptide Neurotensin NTR1 NTS1 TM1 1x54 A L 1 1 22
5T04, 8FMZ, 7L0P, 4BUO, 3ZEV, 4XES, 4XEE, 4GRV, 6ZIN, 6Z4Q, 8FN0, 7L0R, 7L0Q, 4BV0, 6Z66, 6Z4V, 6Z8N, 7L0S, 6YVR, 6ZA8, 6Z4S, 4BWB
0.33 (0.37−0.04) 0 (0−0) 0.21 (0.21−0) -1.75 (-1.25−0.50)
Active
A (Rhodopsin) Peptide Neurotensin NTR1 NTS1 TM3 3x49 E A 1 1 2
4GRV, 4XES
-0.2 (0.01−0.21) 0 (0−0) -0.40 (0−0.40) 0.39 (0.50−0.11) 2 2
Active
A (Rhodopsin) Peptide Neurotensin NTR1 NTS1 ECL2 G A 1 1 4
5T04, 4XEE, 4XES, 4GRV
0 (0−0) 0 (0−0) -1.00 (0−1.00) -0.65 (0.50−1.15)
Inactive
A (Rhodopsin) Peptide Neurotensin NTR1 NTS1 TM5 5x54 I A 1 1 4
3ZEV, 4BV0, 4BWB, 4BUO
-0.32 (0.01−0.33) 0 (0−0) -0.41 (0−0.41) 1.62 (0.50−-1.12) 4
Active
A (Rhodopsin) Peptide Neurotensin NTR1 NTS1 TM7 7x43 V A 1 1 4
5T04, 4XEE, 4XES, 4GRV
0.09 (0.19−0.1) 0 (0−0) -0.61 (0−0.61) 0.96 (0.50−-0.46) 2
Inactive
Active
A (Rhodopsin) Sensory Opsins OPSD OPSD Rhodopsin N-term N C 2 1 19
6FKD, 5W0P, 5DYS, 4BEZ, 5EN0, 4BEY, 4A4M, 6FK9, 6FKC, 6FK7, 6FK6, 6FK8, 5DGY, 6FKA, 3C9M, 2J4Y, 4ZWJ, 2X72, 6FKB
0 (0−0) 0 (0−0) 0.03 (0.68−0.65) -0.87 (-0.02−0.85)
Active
A (Rhodopsin) Sensory Opsins OPSD Rhodopsin TM2 2x60 T I 1 1 2
5EN0, 5DYS
-0.04 (0.04−0.08) -0.13 (0.25−0.38) -0.25 (0.41−0.66) -1.37 (-1.12−0.25) 93
Active
A (Rhodopsin) Sensory Opsins OPSD OPSD Rhodopsin TM3 3x28 E Q 2 1 4
4ZWJ, 2X72, 5DGY, 5W0P
-0.01 (0.01−0.02) -0.5 (0−0.5) -0.01 (0.39−0.40) 0.66 (0.77−0.11) 57
Active
A (Rhodopsin) Sensory Opsins OPSD OPSD Rhodopsin TM6 6x40 M Y 2 1 4
4A4M, 5W0P, 5DGY, 4ZWJ
-0.04 (0.01−0.05) -0.75 (0−0.75) 0.29 (0.53−0.24) -0.04 (-0.71−-0.67) 2 1
Inactive
Active
A (Rhodopsin) Sensory Opsins OPSD Rhodopsin ECL3 D C 1 1 16
6FKD, 5DYS, 4BEZ, 5EN0, 4BEY, 4A4M, 6FK9, 6FKC, 6FK7, 6FK6, 6FK8, 6FKA, 3C9M, 2J4Y, 2X72, 6FKB
0 (0−0) 0 (0−0) -0.01 (0.68−0.69) -0.45 (-0.02−0.43)
Active
A (Rhodopsin) Nucleotide P2Y P2RY1 P2Y12 P2Y1 P2Y12 TM7 7x49 D N 2 1 6
4XNW, 4PXZ, 4PY0, 4XNV, 7PP1, 4NTJ
0.52 (0.72−0.2) 0 (0−0) -0.04 (0.65−0.69) 0.42 (0.85−0.43)
Active
A (Rhodopsin) Peptide Proteinase-activated PAR2 PAR2 TM1 1x46 G A 1 1 3
5NJ6, 5NDZ, 5NDD
-0.43 (0.11−0.54) 0 (0−0) -1.00 (0−1.00) -0.65 (0.50−1.15)
Active
A (Rhodopsin) Peptide Proteinase-activated PAR2 PAR2 TM2 2x37 H A 1 1 3
5NJ6, 5NDZ, 5NDD
0.02 (0.05−0.03) 0 (0−0) -0.61 (0−0.61) 0.39 (0.50−0.11) 3 1 1
Active
A (Rhodopsin) Peptide Proteinase-activated PAR2 PAR2 TM3 3x34 G A 1 1 3
5NJ6, 5NDZ, 5NDD
0.05 (0.07−0.02) 0 (0−0) -1.00 (0−1.00) -0.65 (0.50−1.15) 3
Active
A (Rhodopsin) Peptide Proteinase-activated PAR2 PAR2 TM3 3x43 M L 1 1 3
5NJ6, 5NDZ, 5NDD
0.68 (0.73−0.05) 0 (0−0) -0.03 (0.21−0.24) -0.58 (-1.25−-0.67) 2
Active
A (Rhodopsin) Peptide Proteinase-activated PAR2 PAR2 TM3 3x51 Y A 1 1 3
5NJ6, 5NDZ, 5NDD
-0.66 (0.0−0.66) 0 (0−0) -0.53 (0−0.53) 1.21 (0.50−-0.71) 1
Active
A (Rhodopsin) Peptide Proteinase-activated PAR2 PAR2 TM3 3x53 V E 1 1 3
5NJ6, 5NDZ, 5NDD
-0.06 (0.01−0.07) 0 (0−0) -0.21 (0.40−0.61) 0.57 (0.11−-0.46) 5
Active
A (Rhodopsin) Peptide Proteinase-activated PAR2 PAR2 TM5 5x64 M A 1 1 3
5NJ6, 5NDZ, 5NDD
0.11 (0.12−0.01) 0 (0−0) -0.24 (0−0.24) 1.17 (0.50−-0.67) 1 3
Active
A (Rhodopsin) Peptide Proteinase-activated PAR2 PAR2 TM6 6x38 I A 1 1 3
5NJ6, 5NDZ, 5NDD
0.06 (0.14−0.08) 0 (0−0) -0.41 (0−0.41) 1.62 (0.50−-1.12) 4
Active
A (Rhodopsin) Peptide Proteinase-activated PAR2 PAR2 TM6 6x42 L A 1 1 3
5NJ6, 5NDZ, 5NDD
-0.12 (0.13−0.25) 0 (0−0) -0.21 (0−0.21) 1.75 (0.50−-1.25) 1
Active
Other
A (Rhodopsin) Lipid Platelet-activating factor PTAFR PAF TM6 6x34 A D 1 1 2
5ZKQ, 5ZKP
-0.24 (0−0.24) 0 (0−0) 0.69 (0.69−0) -0.07 (0.43−0.50) 2
Inactive
A (Rhodopsin) Lipid Leukotriene Q9WTK1 BLT1 TM2 2x67 H G 1 1 1
5X33
0.2 (0.27−0.07) 0 (0−0) 0.39 (1.00−0.61) 1.04 (1.15−0.11) 15
Inactive
A (Rhodopsin) Lipid Leukotriene Q9WTK1 BLT1 TM3 3x21 K G 1 1 1
5X33
0.67 (0.68−0.01) 0 (0−0) 0.74 (1.00−0.26) -1.65 (1.15−2.80) 7
Inactive
A (Rhodopsin) Lipid Leukotriene Q9WTK1 BLT1 TM5 5x67 V A 1 1 1
5X33
0.06 (0.09−0.03) 0 (0−0) -0.61 (0−0.61) 0.96 (0.50−-0.46) 1
Inactive
A (Rhodopsin) Lipid Leukotriene Q9WTK1 BLT1 C-term S A 1 1 1
5X33
0 (0−0) 0 (0−0) -0.50 (0−0.50) 0.04 (0.50−0.46)
Inactive
B1 (Secretin) Peptide Corticotropin-releasing factor CRFR1 CRF1 TM1 1x36 V A 1 1 5
8GTG, 8GTI, 4K5Y, 8GTM, 4Z9G
-0.07 (0−0.07) 0 (0−0) -0.61 (0−0.61) 0.96 (0.50−-0.46) 13
Inactive
B1 (Secretin) Peptide Corticotropin-releasing factor CRFR1 CRF1 TM1 1x60 L A 1 1 5
8GTG, 8GTI, 4K5Y, 8GTM, 4Z9G
-0.33 (0−0.33) 0 (0−0) -0.21 (0−0.21) 1.75 (0.50−-1.25)
Inactive
B1 (Secretin) Peptide Corticotropin-releasing factor CRFR1 CRF1 TM2 2x44 W A 1 1 2
4K5Y, 4Z9G
-0.06 (0.07−0.13) 0 (0−0) -0.49 (0−0.49) 2.59 (0.50−-2.09)
Inactive
B1 (Secretin) Peptide Corticotropin-releasing factor CRFR1 CRF1 TM2 2x48 S A 1 1 2
4K5Y, 4Z9G
0.13 (0.2−0.07) 0 (0−0) -0.50 (0−0.50) 0.04 (0.50−0.46)
Inactive
B1 (Secretin) Peptide Corticotropin-releasing factor CRFR1 CRF1 TM4 4x43 K A 1 1 2
4K5Y, 4Z9G
-0.13 (0−0.13) 0 (0−0) -0.26 (0−0.26) -2.30 (0.50−2.80)
Inactive
B1 (Secretin) Peptide Corticotropin-releasing factor CRFR1 CRF1 ECL2 45x52 F A 1 1 2
4K5Y, 4Z9G
-0.13 (0−0.13) 0 (0−0) -0.54 (0−0.54) 2.21 (0.50−-1.71) 15
Inactive
B1 (Secretin) Peptide Corticotropin-releasing factor CRFR1 CRF1 TM5 5x48 I A 1 1 2
4K5Y, 4Z9G
-0.2 (0−0.2) 0 (0−0) -0.41 (0−0.41) 1.62 (0.50−-1.12) 6
Inactive
B1 (Secretin) Peptide Corticotropin-releasing factor CRFR1 CRF1 TM6 6x30 Y A 1 1 2
4K5Y, 4Z9G
-0.73 (0−0.73) 0 (0−0) -0.53 (0−0.53) 1.21 (0.50−-0.71)
Inactive
B1 (Secretin) Peptide Corticotropin-releasing factor CRFR1 CRF1 TM6 6x51 F A 1 1 2
4K5Y, 4Z9G
-0.93 (0−0.93) 0 (0−0) -0.54 (0−0.54) 2.21 (0.50−-1.71) 3
Inactive
B1 (Secretin) Peptide Corticotropin-releasing factor CRFR1 CRF1 TM7 7x38 S A 1 1 2
4K5Y, 4Z9G
-0.13 (0−0.13) 0 (0−0) -0.50 (0−0.50) 0.04 (0.50−0.46) 15
Inactive
B1 (Secretin) Peptide Corticotropin-releasing factor CRFR1 CRF1 TM7 7x53 Y A 1 1 2
4K5Y, 4Z9G
-0.93 (0−0.93) 0 (0−0) -0.53 (0−0.53) 1.21 (0.50−-0.71) Removed 1 1
Inactive
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 TM2 2x56 S C 1 1 2
5VEW, 5VEX
-0.47 (0−0.47) 0 (0−0) 0.18 (0.68−0.50) -0.48 (-0.02−0.46)
Inactive
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 TM2 2x59 I F 1 1 2
5VEW, 5VEX
-0.4 (0−0.4) 0 (0−0) 0.13 (0.54−0.41) -0.59 (-1.71−-1.12)
Intermediate
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 ECL1 T E 1 1 1
5NX2
0 (0−0) 0 (0−0) -0.26 (0.40−0.66) -0.14 (0.11−0.25)
Intermediate
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 ECL1 Q A 1 1 1
5NX2
0 (0−0) 0 (0−0) -0.39 (0−0.39) -0.27 (0.50−0.77)
Intermediate
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 ECL1 D R 1 1 1
5NX2
0 (0−0) 0 (0−0) -0.48 (0.21−0.69) 1.38 (1.81−0.43)
Inactive
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 TM3 3x24 S A 1 1 2
5VEW, 5VEX
-0.2 (0.07−0.27) 0 (0−0) -0.50 (0−0.50) 0.04 (0.50−0.46)
Intermediate
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 TM3 3x31 L F 1 1 1
5NX2
0.2 (0.4−0.2) 0 (0−0) 0.33 (0.54−0.21) -0.46 (-1.71−-1.25)
Inactive
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 TM3 3x32 M C 1 1 2
5VEW, 5VEX
-0.13 (0−0.13) 0 (0−0) 0.44 (0.68−0.24) 0.65 (-0.02−-0.67) 12
Intermediate
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 ICL2 L F 1 1 1
5NX2
0 (0−0) 0 (0−0) 0.33 (0.54−0.21) -0.46 (-1.71−-1.25)
Inactive
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 TM4 4x48 S A 1 1 2
5VEW, 5VEX
0.0 (0.07−0.07) 0 (0−0) -0.50 (0−0.50) 0.04 (0.50−0.46)
Intermediate
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 ECL2 G A 1 1 1
5NX2
0 (0−0) 0 (0−0) -1.00 (0−1.00) -0.65 (0.50−1.15)
Intermediate
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 ECL2 45x52 T A 1 1 1
5NX2
-0.2 (0−0.2) 0 (0−0) -0.66 (0−0.66) 0.25 (0.50−0.25) 15
Inactive
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 TM5 5x51 I C 1 1 2
5VEW, 5VEX
-0.6 (0−0.6) 0 (0−0) 0.27 (0.68−0.41) 1.10 (-0.02−-1.12) 1
Inactive
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 TM5 5x52 G I 1 1 2
5VEW, 5VEX
-0.13 (0.07−0.2) 0 (0−0) -0.59 (0.41−1.00) -2.27 (-1.12−1.15)
Intermediate
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 TM5 5x63 C A 1 1 1
5NX2
-0.07 (0−0.07) 0 (0−0) -0.68 (0−0.68) 0.52 (0.50−-0.02)
Inactive
B1 (Secretin) Peptide Glucagon GLR GLP1R GLP-1 glucagon TM6 6x30 K A 2 1 3
5VEW, 5EE7, 5VEX
-0.2 (0−0.2) 0 (0−0) -0.26 (0−0.26) -2.30 (0.50−2.80)
Inactive
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 TM6 6x31 C F 1 1 2
5VEW, 5VEX
0.0 (0.07−0.07) 0 (0−0) -0.14 (0.54−0.68) -1.69 (-1.71−-0.02) 1
Intermediate
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 TM6 6x42 P A 1 1 1
5NX2
-0.93 (0−0.93) 0 (0−0) -3.16 (0−3.16) 0.36 (0.50−0.14) 2
Intermediate
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 TM6 6x45 G A 1 1 1
5NX2
-1.0 (0−1.0) 0 (0−0) -1.00 (0−1.00) -0.65 (0.50−1.15) 1
Inactive
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 TM6 6x45 G C 1 1 2
5VEW, 5VEX
-1.0 (0−1.0) 0 (0−0) -0.32 (0.68−1.00) -1.17 (-0.02−1.15) 1
Intermediate
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 TM6 6x47 H V 1 1 1
5NX2
-0.73 (0−0.73) 0 (0−0) 0.00 (0.61−0.61) -0.57 (-0.46−0.11) 2
Intermediate
B1 (Secretin) Peptide Glucagon GLP1R GLP-1 TM7 7x56 V A 1 1 1
5NX2
0.0 (0.07−0.07) 0 (0−0) -0.61 (0−0.61) 0.96 (0.50−-0.46) 1 2
Inactive
B1 (Secretin) Peptide Glucagon GLR glucagon TM1 1x48 G A 1 1 1
5EE7
0.2 (0.33−0.13) 0 (0−0) -1.00 (0−1.00) -0.65 (0.50−1.15) 2
Inactive
B1 (Secretin) Peptide Glucagon GLR glucagon TM2 2x39 R A 1 1 2
5YQZ, 5EE7
-1.0 (0−1.0) 0 (0−0) -0.21 (0−0.21) -1.31 (0.50−1.81) 1 2
Inactive
B1 (Secretin) Peptide Glucagon GLR glucagon TM2 2x48 A L 1 1 1
5EE7
0.0 (0.2−0.2) 0 (0−0) 0.21 (0.21−0) -1.75 (-1.25−0.50)
Inactive
B1 (Secretin) Peptide Glucagon GLR glucagon TM2 2x56 S A 1 1 1
5EE7
-0.2 (0.27−0.47) 0 (0−0) -0.50 (0−0.50) 0.04 (0.50−0.46)
Inactive
B1 (Secretin) Peptide Glucagon GLR glucagon TM2 2x59 V F 1 1 1
5EE7
-0.4 (0−0.4) 0 (0−0) -0.07 (0.54−0.61) -1.25 (-1.71−-0.46)
Inactive
B1 (Secretin) Peptide Glucagon GLR glucagon ECL1 G E 1 1 1
5EE7
0 (0−0) 0 (0−0) -0.60 (0.40−1.00) -1.04 (0.11−1.15)
Inactive
B1 (Secretin) Peptide Glucagon GLR glucagon TM3 3x24 G A 1 1 1
5EE7
-0.33 (0.07−0.4) 0 (0−0) -1.00 (0−1.00) -0.65 (0.50−1.15)
Inactive
B1 (Secretin) Peptide Glucagon GLR glucagon TM4 4x54 M A 1 1 1
5EE7
0.2 (0.27−0.07) 0 (0−0) -0.24 (0−0.24) 1.17 (0.50−-0.67)
Inactive
B1 (Secretin) Peptide Glucagon GLR glucagon TM6 6x48 E F 1 1 1
5EE7
-0.14 (0.13−0.27) 0 (0−0) 0.14 (0.54−0.40) -1.82 (-1.71−0.11) 6
Inactive
B1 (Secretin) Peptide Glucagon GLR glucagon TM7 7x39 F A 1 1 1
5EE7
-0.26 (0.07−0.33) 0 (0−0) -0.54 (0−0.54) 2.21 (0.50−-1.71)
Inactive
C (Glutamate) Amino acid Metabotropic glutamate GRM5 mGlu5 TM1 1x35 E A 1 1 6
7P2L, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
-0.04 (0.05−0.09) 0 (0−0) -0.40 (0−0.40) 0.39 (0.50−0.11)
Inactive
C (Glutamate) Amino acid Metabotropic glutamate GRM5 mGlu5 TM3 3x48 N Y 1 1 6
7P2L, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
-0.36 (0.05−0.41) 0 (0−0) -0.12 (0.53−0.65) -1.56 (-0.71−0.85)
Inactive
C (Glutamate) Amino acid Metabotropic glutamate GRM5 mGlu5 TM3 3x50 I A 1 1 6
7P2L, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
-0.4 (0.05−0.45) 0 (0−0) -0.41 (0−0.41) 1.62 (0.50−-1.12)
Inactive
C (Glutamate) Amino acid Metabotropic glutamate GRM5 mGlu5 ICL2 G M 1 1 6
7P2L, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
0 (0−0) 0 (0−0) -0.76 (0.24−1.00) -1.82 (-0.67−1.15)
Active
Inactive
C (Glutamate) Amino acid Metabotropic glutamate GRM5 mGlu5 TM5 5x42 T A 1 1 8
7P2L, 7FD9, 7FD8, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
-0.04 (0.05−0.09) 0 (0−0) -0.66 (0−0.66) 0.25 (0.50−0.25)
Active
Inactive
C (Glutamate) Amino acid Metabotropic glutamate GRM5 mGlu5 TM5 5x53 S A 1 1 8
7P2L, 7FD9, 7FD8, 6FFH, 5CGC, 5CGD, 4OO9, 6FFI
-0.14 (0−0.14) 0 (0−0) -0.50 (0−0.50) 0.04 (0.50−0.46)
Inactive
F (Frizzled) Protein Frizzled SMO SMO TM3 3x40 V F 1 1 2
5L7I, 5L7D
-0.09 (0−0.09) -0.09 (0−0.09) -0.07 (0.54−0.61) -1.25 (-1.71−-0.46) 1
Active
A (Rhodopsin) Nucleotide Adenosine AA2AR A2A TM3 3x39 S A 1 1 1
5WF6
-0.69 (0.03−0.72) 0 (0−0) -0.50 (0−0.50) 0.04 (0.50−0.46) Removed 5