Stabilising Mutation Analyser

Group by: Mutant Subsets: Only show mutations present in minimum 2 GPCRs
STATE TARGETS MUTATIONS FREQUENCY SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS
No. Receptor Families
No. Structures
PDBs Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Active
Inactive
Intermediate
A (Rhodopsin)
Peptide
Lipid
Sensory
Leukotriene
Neurotensin
Opsins
OPSD
NTR1
OPSD
Q9WTK1
BLT1
NTS1
Rhodopsin
ECL2
S
G
D
N
A
C
4 3 17
5EN0, 2X72, 5W0P, 4BEY, 4ZWJ, 2J4Y, 5T04, 4BEZ, 4XEE, 4A4M, 4GRV, 6CMO, 3C9M, 5DYS, 5X33, 4XES, 5DGY
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A
C
1 1 3
5NX2, 5VEX, 5VEW
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A
1 1 3
5NDD, 5NJ6, 5NDZ
Active
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
Cannabinoid
LPAR1
CNR1
LPA1
CB1
TM5 5x37
D
E
K
C
2 2 4
5XR8, 4Z36, 5TGZ, 5XRA
1
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K
1 1 1
5VBL
Pos Match 25
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y
1 1 2
5X93, 5XPR
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM2 2x59
I
V
F
2 1 3
5VEX, 5EE7, 5VEW
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q
2 1 5
2X72, 4ZWJ, 5W0P, 6CMO, 5DGY
10
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A
1 1 2
5X93, 5XPR
4
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F
1 1 2
5L7I, 5L7D
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CCR9
CCR9
CXCR4
TM6 6x36
T
V
A
P
2 1 4
5LWE, 3OE0, 3OE9, 4RWS
2 1 5
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A
1 1 2
4Z9G, 4K5Y
Pos Match 1
Inactive
A (Rhodopsin)
Peptide
Aminergic
Dopamine
Apelin
Adrenoceptors
ADRB1
DRD2
APJ
β1
D2
apelin
TM3 3x40
I
V
A
V
3 3 4
5VBL, 5A8E, 4BVN, 6CM4
2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C
1 1 2
5VEX, 5VEW
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A
1 1 4
4BWB, 3ZEV, 4BUO, 4BV0
Inactive
Intermediate
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLP1R
CRFR1
CRF1
GLP-1
ECL2 45x52
T
F
A
2 2 3
5NX2, 4Z9G, 4K5Y
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A
1 1 2
4Z9G, 4K5Y
Active
Inactive
Intermediate
A (Rhodopsin)
Protein
Aminergic
Dopamine
Adrenoceptors
5-Hydroxytryptamine
Chemokine
5HT2B
5HT1B
DRD3
ADRB1
CXCR4
ADRB2
β1
β2
CXCR4
5-HT1B
5-HT2B
D3
TM3 3x41
L
E
M
W
6 4 24
5A8E, 4RWS, 5TVN, 4IAQ, 6DS0, 4IAR, 4IB4, 3D4S, 5V54, 3OE6, 5TUD, 3OE0, 3NYA, 3OE9, 3OE8, 3NY8, 3PBL, 4NC3, 6DRY, 6DRZ, 6DRX, 3ODU, 6G79, 3NY9
1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A
1 1 1
5X33
1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E
1 1 3
5NDD, 5NJ6, 5NDZ
5
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A
1 1 1
5EE7
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A
1 1 5
5CGD, 5CGC, 6FFI, 6FFH, 4OO9
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K
1 1 1
4BVN
8
Active
Inactive
A (Rhodopsin)
Peptide
Aminergic
Adrenoceptors
Endothelin
ADRB1
EDNRB
ETB
β1
TM7 7x48
F
I
A
M
2 2 26
2VT4, 5A8E, 3ZPR, 4GPO, 4AMI, 5XPR, 3ZPQ, 5F8U, 2Y01, 6IBL, 6H7O, 2Y04, 2YCZ, 4AMJ, 6H7N, 2YCX, 6H7J, 5X93, 6H7M, 2Y03, 2YCY, 4BVN, 6H7L, 2Y00, 2Y02, 2YCW
Inactive
Intermediate
A (Rhodopsin)
Aminergic
Peptide
Nucleotide
Dopamine
Adenosine
Neurotensin
AA2AR
AA1R
DRD2
NTR1
NTS1
D2
A2A
A1
TM6 6x37
L
A
4 3 26
5OLZ, 5IU4, 5NM4, 5OLV, 4GRV, 6CM4, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5N2S, 5IUB, 3UZC, 5OM1
1 1 4
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y12
P2Y1
TM7 7x49
D
N
2 1 5
4XNW, 4NTJ, 4XNV, 4PXZ, 4PY0
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A
1 1 4
5T04, 4XEE, 4XES, 4GRV
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM2 2x52
A
L
2 1 28
4UHR, 5OLZ, 5IU4, 5NM4, 5OLV, 4UG2, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 2YDV, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 2YDO, 5MZP, 5NLX, 5MZJ, 5N2S, 5IUB, 3UZC, 5OM1
1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L
1 1 2
5A8E, 4BVN
Pos Match Pos Match 3
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A
1 1 1
5NX2
2 2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A
1 1 3
5NDD, 5NJ6, 5NDZ
1 3
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A
1 1 5
5CGD, 5CGC, 6FFI, 6FFH, 4OO9
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A
1 1 1
5LWE
4
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I
1 1 2
5VEX, 5VEW
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A
1 1 2
5YQZ, 5EE7
2
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S
1 1 24
2VT4, 5A8E, 3ZPR, 4GPO, 4AMI, 5F8U, 3ZPQ, 2Y01, 6IBL, 6H7O, 2Y04, 2YCZ, 4AMJ, 6H7N, 2YCX, 6H7J, 6H7M, 2Y03, 2YCY, 4BVN, 6H7L, 2Y00, 2Y02, 2YCW
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Dopamine
Adenosine
AA2AR
AA1R
DRD2
D2
A2A
A1
TM6 6x41
L
V
A
3 2 25
5OLZ, 5IU4, 5NM4, 5OLV, 6CM4, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5N2S, 5IUB, 3UZC, 5OM1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A
1 1 23
5OLZ, 5IU4, 5NM4, 5OLV, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5IUB, 3UZC, 5OM1
1 2
Active
Inactive
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L
1 1 8
4BWB, 4BV0, 5T04, 3ZEV, 4BUO, 4XES, 4XEE, 4GRV
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E
1 1 4
6AKY, 4MBS, 5UIW, 6AKX
3 1 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM3 3x36
T
A
2 1 24
5OLZ, 5IU4, 5NM4, 5OLV, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5N2S, 5IUB, 3UZC, 5OM1
20
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y
1 1 5
5CGD, 5CGC, 6FFI, 6FFH, 4OO9
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A
1 1 23
5OLZ, 5IU4, 5NM4, 5OLV, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5IUB, 3UZC, 5OM1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM5 5x63
Y
L
A
2 1 24
5OLZ, 5IU4, 5NM4, 5OLV, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5N2S, 5IUB, 3UZC, 5OM1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F
1 1 1
5EE7
1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A
1 1 4
4UHR, 2YDO, 2YDV, 4UG2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLR
CRFR1
CRF1
glucagon
TM2 2x48
S
A
L
A
2 2 3
4Z9G, 5EE7, 4K5Y
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I
1 1 2
5EN0, 5DYS
19
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A
1 1 2
5VEX, 5VEW
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
ECL1
T
G
L
Q
D
F
E
A
R
2 1 2
5NX2, 5EE7
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A
1 1 4
4UHR, 2YDO, 2YDV, 4UG2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A
1 1 1
5LWE
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y
1 1 4
6AKY, 4MBS, 5UIW, 6AKX
2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A
1 1 1
5LWE
6
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A
1 1 1
5NX2
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E
1 1 3
5XR8, 5TGZ, 5XRA
1 5
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A
1 1 5
5CGD, 5CGC, 6FFI, 6FFH, 4OO9
Pos Match
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A
1 1 4
5XR8, 5U09, 5XRA, 5TGZ
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A
1 1 2
4Z9G, 4K5Y
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A
1 1 3
5NDD, 5NJ6, 5NDZ
1 1 1
Inactive
Intermediate
A (Rhodopsin)
Lipid
Aminergic
Adrenoceptors
Free fatty acid
ADRB1
FFAR1
FFA1
β1
TM5 5x58
Y
F
A
2 2 22
2VT4, 5A8E, 3ZPR, 4PHU, 4GPO, 4AMI, 5F8U, 3ZPQ, 2Y01, 5TZR, 2Y04, 2YCZ, 4AMJ, 2YCX, 5KW2, 2Y03, 2YCY, 4BVN, 5TZY, 2Y02, 2Y00, 2YCW
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A
1 1 2
5X93, 5XPR
2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A
1 1 3
5NDD, 5NJ6, 5NDZ
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A
1 1 1
5EE7
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A
1 1 2
4Z9G, 4K5Y
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM2 2x56
S
A
C
2 1 3
5VEX, 5EE7, 5VEW
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A
1 1 2
4Z9G, 4K5Y
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A
1 1 4
4PHU, 5KW2, 5TZY, 5TZR
2 1 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C
1 1 1
4RWS
16
Intermediate
A (Rhodopsin)
Peptide
Lipid
Free fatty acid
Proteinase-activated
PAR2
FFAR1
FFA1
PAR2
TM3 3x34
F
G
A
2 2 5
4PHU, 5NDD, 5NJ6, 5NDZ, 5TZR
1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A
1 1 24
2VT4, 5A8E, 3ZPR, 4GPO, 4AMI, 5F8U, 3ZPQ, 2Y01, 6IBL, 6H7O, 2Y04, 2YCZ, 4AMJ, 6H7N, 2YCX, 6H7J, 6H7M, 2Y03, 2YCY, 4BVN, 6H7L, 2Y00, 2Y02, 2YCW
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A
1 1 1
5LWE
1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M
1 1 5
5CGD, 5CGC, 6FFI, 6FFH, 4OO9
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM7 7x41
T
S
A
2 1 24
5OLZ, 5IU4, 5NM4, 5OLV, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5N2S, 5IUB, 3UZC, 5OM1
6
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D
1 1 4
6AKY, 4MBS, 5UIW, 6AKX
2 1 6
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A
1 1 3
5NDD, 5NJ6, 5NDZ
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N
1 1 4
6AKY, 4MBS, 5UIW, 6AKX
6
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A
1 1 2
4Z9G, 4K5Y
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L
1 1 3
5NDD, 5NJ6, 5NDZ
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G
1 1 1
5X33
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A
1 1 1
5EE7
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A
1 1 1
5LWE
1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G
1 1 1
5X33
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N
1 1 1
5WF5
Pos Match 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A
1 1 1
5X93
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A
1 1 1
5LWE
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A
1 1 1
5WF6
Pos Match 1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C
1 1 2
3PDS, 4QKX
10
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V
1 1 24
2VT4, 5A8E, 3ZPR, 4GPO, 4AMI, 5F8U, 3ZPQ, 2Y01, 6IBL, 6H7O, 2Y04, 2YCZ, 4AMJ, 6H7N, 2YCX, 6H7J, 6H7M, 2Y03, 2YCY, 4BVN, 6H7L, 2Y00, 2Y02, 2YCW
2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C
1 1 2
5VEX, 5VEW
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V
1 1 1
5NX2
1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y
2 1 5
4ZWJ, 4A4M, 5W0P, 6CMO, 5DGY
1 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLP1R
GLR
CRFR1
CRF1
GLP-1
glucagon
TM6 6x30
Y
K
A
3 2 5
4K5Y, 5VEX, 4Z9G, 5EE7, 5VEW
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A
1 1 2
4Z9G, 4K5Y
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM3 3x24
S
G
A
2 1 3
5VEX, 5EE7, 5VEW
Intermediate
A (Rhodopsin)
Peptide
Lipid
Neurotensin
Free fatty acid
FFAR1
NTR1
FFA1
NTS1
TM3 3x49
G
E
A
2 2 6
4PHU, 5KW2, 5TZY, 4XES, 4GRV, 5TZR
Pos Match 2
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N
1 1 2
6BQH, 6BQG
Pos Match 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A
1 1 4
4UHR, 2YDO, 2YDV, 4UG2
9
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A
1 1 5
5CGD, 5CGC, 6FFI, 6FFH, 4OO9
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C
1 1 1
4Z36
4
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A
1 1 2
4Z9G, 4K5Y
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C
1 1 1
5LWE
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A
1 1 3
5NDD, 5NJ6, 5NDZ
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F
1 1 2
5VEX, 5VEW
1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L
1 1 18
2VT4, 5A8E, 2YCZ, 4AMJ, 2YCX, 3ZPR, 2Y04, 4GPO, 4AMI, 5F8U, 3ZPQ, 2Y03, 2YCY, 2Y01, 4BVN, 2Y00, 2Y02, 2YCW
STATE TARGETS MUTATIONS FREQUENCY DATA (MUTANT) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A 1 1 23
5OLZ, 5IU4, 5NM4, 5OLV, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5IUB, 3UZC, 5OM1
0.13 0 0.50
Inactive
Intermediate
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLP1R
CRFR1
CRF1
GLP-1
ECL2 45x52
T
F
A 2 2 3
5NX2, 4Z9G, 4K5Y
0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N 1 1 1
5WF5
0.03 0.65 0.85 Pos & AA Mutant Match 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L 1 1 2
5A8E, 4BVN
0.03 0.21 -1.25 Pos Match (But Not Mutant AA) Pos & Mutant AA Match 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A 1 1 1
5EE7
0.07 0 0.50
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37
E
K 1 1 3
5XR8, 5TGZ, 5XRA
0.11 0.26 2.80 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A 1 1 5
5CGD, 5CGC, 6FFI, 6FFH, 4OO9
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLP1R
GLR
CRFR1
CRF1
GLP-1
glucagon
TM6 6x30
Y
K
A 3 2 5
4K5Y, 5VEX, 4Z9G, 5EE7, 5VEW
0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y 1 1 2
5X93, 5XPR
0.09 0.53 -0.71
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V 1 1 24
2VT4, 5A8E, 3ZPR, 4GPO, 4AMI, 5F8U, 3ZPQ, 2Y01, 6IBL, 6H7O, 2Y04, 2YCZ, 4AMJ, 6H7N, 2YCX, 6H7J, 6H7M, 2Y03, 2YCY, 4BVN, 6H7L, 2Y00, 2Y02, 2YCW
0.23 0.33 0.61 -0.46 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F 1 1 2
5VEX, 5VEW
0.07 0.54 -1.71 1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y 2 1 5
4ZWJ, 4A4M, 5W0P, 6CMO, 5DGY
0.01 0.53 -0.71 1 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.14 0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A 1 1 4
4UHR, 2YDO, 2YDV, 4UG2
0.03 0 0.50 9
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.13 0 0.50 1 3
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM2 2x52
A
L 2 1 28
4UHR, 5OLZ, 5IU4, 5NM4, 5OLV, 4UG2, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 2YDV, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 2YDO, 5MZP, 5NLX, 5MZJ, 5N2S, 5IUB, 3UZC, 5OM1
0.63 0.21 -1.25 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D 1 1 4
6AKY, 4MBS, 5UIW, 6AKX
0.69 0.43 2 1 6
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A 1 1 2
4Z9G, 4K5Y
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.13 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C 1 1 1
5LWE
0.02 0.68 -0.02
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A 1 1 4
4PHU, 5KW2, 5TZY, 5TZR
0.06 0 0.50 2 1 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y 1 1 5
5CGD, 5CGC, 6FFI, 6FFH, 4OO9
0.05 0.53 -0.71
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A 1 1 2
4Z9G, 4K5Y
0 0.50 1
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM5 5x58
Y
F 1 1 4
4PHU, 5KW2, 5TZY, 5TZR
0.01 0.54 -1.71
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E 1 1 3
5XR8, 5TGZ, 5XRA
0.04 0.40 0.11 1 5
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A 1 1 2
4Z9G, 4K5Y
0.07 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.11 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A 1 1 1
5LWE
0.07 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM3 3x36
T
A 2 1 24
5OLZ, 5IU4, 5NM4, 5OLV, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5N2S, 5IUB, 3UZC, 5OM1
0.02 0 0.50 20
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
D
R 1 1 1
5NX2
0.21 1.81
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A 1 1 2
5X93, 5XPR
0.07 0 0.50 2
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A 1 1 4
5T04, 4XEE, 4XES, 4GRV
0.19 0 0.50
Active
Inactive
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L 1 1 8
4BWB, 4BV0, 5T04, 3ZEV, 4BUO, 4XES, 4XEE, 4GRV
0.37 0.21 -1.25
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM5 5x58
Y
A 1 1 18
2VT4, 5A8E, 2YCZ, 4AMJ, 2YCX, 3ZPR, 2Y04, 4GPO, 4AMI, 5F8U, 3ZPQ, 2Y03, 2YCY, 2Y01, 4BVN, 2Y00, 2Y02, 2YCW
0.03 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36
T
P 1 1 3
3OE0, 3OE9, 4RWS
0.0 3.16 0.14 2 1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N 1 1 4
6AKY, 4MBS, 5UIW, 6AKX
0.03 0.65 0.85 6
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A 1 1 5
5CGD, 5CGC, 6FFI, 6FFH, 4OO9
0 0.50 Pos & Mutant AA Match
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C 1 1 2
5VEX, 5VEW
0.68 -0.02 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A 1 1 2
4Z9G, 4K5Y
0 0.50 Pos & Mutant AA Match 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A 1 1 2
5X93, 5XPR
0.1 0 0.50 4
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.0 0 0.50 1
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Dopamine
Adenosine
AA2AR
AA1R
DRD2
D2
A2A
A1
TM6 6x41
L
V
A 3 2 25
5OLZ, 5IU4, 5NM4, 5OLV, 6CM4, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5N2S, 5IUB, 3UZC, 5OM1
0.05 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A 1 1 1
5NX2
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2
L
F 1 1 1
5NX2
0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A 1 1 1
5EE7
0.27 0 0.50
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term
D
N
C 2 1 12
5EN0, 2X72, 5W0P, 4BEY, 4ZWJ, 2J4Y, 4BEZ, 4A4M, 6CMO, 3C9M, 5DYS, 5DGY
0.68 -0.02
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E 1 1 3
5NDD, 5NJ6, 5NDZ
0.01 0.40 0.11 5
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A 1 1 1
5WF6
0.03 0 0.50 Pos & AA Mutant Match 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36
V
A 1 1 1
5LWE
0.02 0 0.50 2 1 5
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K 1 1 1
4BVN
0.04 0.11 0.26 2.80 8
Active
Inactive
Intermediate
A (Rhodopsin)
Protein
Aminergic
Dopamine
Adrenoceptors
5-Hydroxytryptamine
Chemokine
5HT2B
5HT1B
DRD3
ADRB1
CXCR4
ADRB2
β1
β2
CXCR4
5-HT1B
5-HT2B
D3
TM3 3x41
L
E
M
W 6 4 24
5A8E, 4RWS, 5TVN, 4IAQ, 6DS0, 4IAR, 4IB4, 3D4S, 5V54, 3OE6, 5TUD, 3OE0, 3NYA, 3OE9, 3OE8, 3NY8, 3PBL, 4NC3, 6DRY, 6DRZ, 6DRX, 3ODU, 6G79, 3NY9
0.03 0.49 -2.09 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x56
S
A 1 1 1
5EE7
0.27 0 0.50
Inactive
Intermediate
A (Rhodopsin)
Aminergic
Peptide
Nucleotide
Dopamine
Adenosine
Neurotensin
AA2AR
AA1R
DRD2
NTR1
NTS1
D2
A2A
A1
TM6 6x37
L
A 4 3 26
5OLZ, 5IU4, 5NM4, 5OLV, 4GRV, 6CM4, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5N2S, 5IUB, 3UZC, 5OM1
0.04 0 0.50 1 1 4
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A 1 1 2
5YQZ, 5EE7
0 0.50 2
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q 2 1 5
2X72, 4ZWJ, 5W0P, 6CMO, 5DGY
0.01 0.39 0.77 10
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A 1 1 1
5LWE
0.06 0 0.50 1
Intermediate
A (Rhodopsin)
Peptide
Lipid
Neurotensin
Free fatty acid
FFAR1
NTR1
FFA1
NTS1
TM3 3x49
G
E
A 2 2 6
4PHU, 5KW2, 5TZY, 4XES, 4GRV, 5TZR
0.01 0 0.50 Pos & Mutant AA Match 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A 1 1 1
5EE7
0.33 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM7 7x41
T
S
A 2 1 24
5OLZ, 5IU4, 5NM4, 5OLV, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5N2S, 5IUB, 3UZC, 5OM1
0.38 0 0.50 6
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.05 0 0.50 1 1 1
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A 1 1 4
4BWB, 3ZEV, 4BUO, 4BV0
0.02 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C 1 1 1
4RWS
0.68 -0.02 16
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A 1 1 1
5X33
0.08 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A 1 1 2
4Z9G, 4K5Y
0 0.50 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L 1 1 18
2VT4, 5A8E, 2YCZ, 4AMJ, 2YCX, 3ZPR, 2Y04, 4GPO, 4AMI, 5F8U, 3ZPQ, 2Y03, 2YCY, 2Y01, 4BVN, 2Y00, 2Y02, 2YCW
0.11 0.11 0.21 -1.25
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V 1 1 1
5NX2
0.61 -0.46 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A 1 1 1
5LWE
0.08 0 0.50 6
Active
Inactive
Intermediate
A (Rhodopsin)
Peptide
Lipid
Leukotriene
Neurotensin
NTR1
Q9WTK1
BLT1
NTS1
ECL2
S
G
A 2 2 5
5X33, 5T04, 4XEE, 4XES, 4GRV
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F 1 1 1
5EE7
0.13 0.54 -1.71 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A 1 1 1
5LWE
0.14 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y 1 1 4
6AKY, 4MBS, 5UIW, 6AKX
0.07 0.53 -0.71 2
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A 1 1 5
5CGD, 5CGC, 6FFI, 6FFH, 4OO9
0.05 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E 1 1 4
6AKY, 4MBS, 5UIW, 6AKX
0.12 0.40 0.11 3 1 2
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C 1 1 2
3PDS, 4QKX
0.0 0.68 -0.02 10
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N 1 1 2
6BQH, 6BQG
0.67 0.65 0.85 Pos & AA Mutant Match 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M 1 1 5
5CGD, 5CGC, 6FFI, 6FFH, 4OO9
0.24 -0.67
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A 1 1 1
5X93
0.08 0 0.50 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM5 5x63
Y
L
A 2 1 24
5OLZ, 5IU4, 5NM4, 5OLV, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5N2S, 5IUB, 3UZC, 5OM1
0.06 0 0.50
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A 1 1 4
5XR8, 5U09, 5XRA, 5TGZ
0.01 0 0.50 1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48
F
M 1 1 24
2VT4, 5A8E, 3ZPR, 4GPO, 4AMI, 5F8U, 3ZPQ, 2Y01, 6IBL, 6H7O, 2Y04, 2YCZ, 4AMJ, 6H7N, 2YCX, 6H7J, 6H7M, 2Y03, 2YCY, 4BVN, 6H7L, 2Y00, 2Y02, 2YCW
0.05 0.24 -0.67
Inactive
A (Rhodopsin)
Peptide
Aminergic
Dopamine
Apelin
DRD2
APJ
D2
apelin
TM3 3x40
I
V
A 2 2 2
5VBL, 6CM4
0.06 0 0.50 2
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K 1 1 1
5VBL
0.26 2.80 Pos Match (But Not Mutant AA) 25
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
ECL1
T
G
E 2 1 2
5NX2, 5EE7
0.40 0.11
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A 1 1 2
5VEX, 5VEW
0.07 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Lipid
Free fatty acid
Proteinase-activated
PAR2
FFAR1
FFA1
PAR2
TM3 3x34
F
G
A 2 2 5
4PHU, 5NDD, 5NJ6, 5NDZ, 5TZR
0.07 0 0.50 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM3 3x24
S
G
A 2 1 3
5VEX, 5EE7, 5VEW
0.07 0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48
I
A 1 1 2
5X93, 5XPR
0.13 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I 1 1 2
5VEX, 5VEW
0.07 0.41 -1.12
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x56
S
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM3 3x40
I
V 1 1 2
5A8E, 4BVN
0.24 0.61 -0.46 2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM2 2x59
I
V
F 2 1 3
5VEX, 5EE7, 5VEW
0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48
A
L 1 1 1
5EE7
0.2 0.21 -1.25
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F 1 1 2
5L7I, 5L7D
0.54 -1.71 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G 1 1 1
5X33
0.67 1.00 1.15 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A 1 1 5
5CGD, 5CGC, 6FFI, 6FFH, 4OO9
0.05 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A 1 1 1
5LWE
0.12 0 0.50 1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S 1 1 24
2VT4, 5A8E, 3ZPR, 4GPO, 4AMI, 5F8U, 3ZPQ, 2Y01, 6IBL, 6H7O, 2Y04, 2YCZ, 4AMJ, 6H7N, 2YCX, 6H7J, 6H7M, 2Y03, 2YCY, 4BVN, 6H7L, 2Y00, 2Y02, 2YCW
0.04 0.50 0.46
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48
S
A 1 1 2
4Z9G, 4K5Y
0.2 0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A 1 1 4
4UHR, 2YDO, 2YDV, 4UG2
0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A 1 1 4
4UHR, 2YDO, 2YDV, 4UG2
0.13 0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y12
P2Y1
TM7 7x49
D
N 2 1 5
4XNW, 4NTJ, 4XNV, 4PXZ, 4PY0
0.72 0.65 0.85
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A 1 1 1
5NX2
0.07 0 0.50 2 2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L 1 1 3
5NDD, 5NJ6, 5NDZ
0.73 0.21 -1.25
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37
D
C 1 1 1
4Z36
0.68 -0.02 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F 1 1 1
5NX2
0.4 0.54 -1.71
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C 1 1 1
4Z36
0.01 0.68 -0.02 4
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A 1 1 24
2VT4, 5A8E, 3ZPR, 4GPO, 4AMI, 5F8U, 3ZPQ, 2Y01, 6IBL, 6H7O, 2Y04, 2YCZ, 4AMJ, 6H7N, 2YCX, 6H7J, 6H7M, 2Y03, 2YCY, 4BVN, 6H7L, 2Y00, 2Y02, 2YCW
0.1 0.11 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A 1 1 23
5OLZ, 5IU4, 5NM4, 5OLV, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5IUB, 3UZC, 5OM1
0.08 0 0.50 1 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
G
Q
A 1 1 1
5NX2
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A 1 1 1
5LWE
0.03 0 0.50 4
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G 1 1 1
5X33
0.25 1.00 1.15
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A 1 1 1
5NX2
0 0.50
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I 1 1 2
5EN0, 5DYS
0.03 0.29 0.41 -1.12 19
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C 1 1 2
5VEX, 5VEW
0.68 -0.02
STATE TARGETS MUTATIONS FREQUENCY DATA (WILD TYPE) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50 V
A
1 1 1
5LWE
0.02 0.61 -0.46 1
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37 D
C
1 1 1
4Z36
0.01 0.69 0.43 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48 I
A
1 1 2
5X93, 5XPR
0.15 0.41 -1.12
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42 L
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.24 0.21 -1.25
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35 E
A
1 1 5
5CGD, 5CGC, 6FFI, 6FFH, 4OO9
0.09 0.40 0.11
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM3 3x36 T
A
2 1 24
5OLZ, 5IU4, 5NM4, 5OLV, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5N2S, 5IUB, 3UZC, 5OM1
0.05 0.66 0.25 20
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL2 45x52 T
A
1 1 1
5NX2
0.2 0.66 0.25
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36 K
A
1 1 2
5X93, 5XPR
0.06 0.26 2.80 2
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x49 G
A
1 1 4
4PHU, 5KW2, 5TZY, 5TZR
0.01 1.00 1.15 Pos & Wild Type AA Match 2
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67 H
G
1 1 1
5X33
0.08 0.61 0.11
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x59 V
F
1 1 1
5EE7
0.4 0.61 -0.46
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38 I
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.08 0.41 -1.12
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55 R
Y
1 1 2
5X93, 5XPR
0.02 0.21 1.81
Active
Inactive
Intermediate
A (Rhodopsin)
Protein
Aminergic
Dopamine
5-Hydroxytryptamine
Chemokine
DRD3
CXCR4
5HT1B
CXCR4
5-HT1B
D3
TM3 3x41 L
W
3 3 11
4RWS, 5V54, 3OE6, 3OE8, 3OE0, 4IAQ, 3OE9, 3PBL, 3ODU, 6G79, 4IAR
0.31 0.21 -1.25 1
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40 L
A
1 1 4
4PHU, 5KW2, 5TZY, 5TZR
0.03 0.21 -1.25 2 1 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM6 6x41 V
A
1 1 23
5OLZ, 5IU4, 5NM4, 5OLV, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5IUB, 3UZC, 5OM1
0.41 0.61 -0.46
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48 A
L
1 1 1
5EE7
0.2 0 0.50
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63 H
C
1 1 2
3PDS, 4QKX
0.03 0.11 0.61 0.11 10
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32 M
C
1 1 2
5VEX, 5VEW
0.13 0.24 -0.67
Inactive
Intermediate
A (Rhodopsin)
Lipid
Aminergic
Adrenoceptors
Free fatty acid
ADRB1
FFAR1
FFA1
β1
TM5 5x58 Y
F
A
2 2 22
2VT4, 5A8E, 3ZPR, 4PHU, 4GPO, 4AMI, 5F8U, 3ZPQ, 2Y01, 5TZR, 2Y04, 2YCZ, 4AMJ, 2YCX, 5KW2, 2Y03, 2YCY, 4BVN, 5TZY, 2Y02, 2Y00, 2YCW
0.71 0.53 -0.71
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31 D
K
1 1 1
4BVN
0.1 0.22 0.69 0.43 8
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
ECL2 45x52 F
A
1 1 2
4Z9G, 4K5Y
0.13 0.54 -1.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48 T
A
1 1 1
5LWE
0.05 0.66 0.25 4
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53 M
V
1 1 24
2VT4, 5A8E, 3ZPR, 4GPO, 4AMI, 5F8U, 3ZPQ, 2Y01, 6IBL, 6H7O, 2Y04, 2YCZ, 4AMJ, 6H7N, 2YCX, 6H7J, 6H7M, 2Y03, 2YCY, 4BVN, 6H7L, 2Y00, 2Y02, 2YCW
0.07 0.33 0.24 -0.67 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31 C
F
1 1 2
5VEX, 5VEW
0.07 0.68 -0.02 1
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40 V
F
1 1 2
5L7I, 5L7D
0.09 0.09 0.61 -0.46 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53 S
A
1 1 5
5CGD, 5CGC, 6FFI, 6FFH, 4OO9
0.14 0.50 0.46
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 D
R
1 1 1
5NX2
0.69 0.43
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
ECL2 G
A
1 1 4
5T04, 4XEE, 4XES, 4GRV
1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52 G
I
1 1 2
5VEX, 5VEW
0.2 1.00 1.15
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37 E
K
1 1 3
5XR8, 5TGZ, 5XRA
0.03 0.40 0.11 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46 L
A
1 1 4
4UHR, 2YDO, 2YDV, 4UG2
0.9 0.21 -1.25
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43 K
A
1 1 23
5OLZ, 5IU4, 5NM4, 5OLV, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5IUB, 3UZC, 5OM1
0.16 0.26 2.80
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56 V
A
1 1 1
5NX2
0.07 0.61 -0.46 2 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM7 7x41 S
A
1 1 23
5OLZ, 5IU4, 5NM4, 5OLV, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5IUB, 3UZC, 5OM1
0.16 0.50 0.46 6
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43 K
A
1 1 2
4Z9G, 4K5Y
0.13 0.26 2.80
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48 S
A
1 1 2
5VEX, 5VEW
0.07 0.50 0.46
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55 R
A
1 1 23
5OLZ, 5IU4, 5NM4, 5OLV, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5IUB, 3UZC, 5OM1
0.05 0.21 1.81 1 2
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48 F
M
1 1 24
2VT4, 5A8E, 3ZPR, 4GPO, 4AMI, 5F8U, 3ZPQ, 2Y01, 6IBL, 6H7O, 2Y04, 2YCZ, 4AMJ, 6H7N, 2YCX, 6H7J, 6H7M, 2Y03, 2YCY, 4BVN, 6H7L, 2Y00, 2Y02, 2YCW
0.06 0.33 0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38 S
A
1 1 2
4Z9G, 4K5Y
0.13 0.50 0.46 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53 V
E
1 1 3
5NDD, 5NJ6, 5NDZ
0.07 0.61 -0.46 5
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM3 3x24 G
A
1 1 1
5EE7
0.4 1.00 1.15
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32 R
E
1 1 3
5XR8, 5TGZ, 5XRA
0.31 0.21 1.81 1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47 S
C
1 1 1
5LWE
0.56 0.50 0.46
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54 S
A
1 1 2
5X93, 5XPR
0.05 0.50 0.46 4
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60 L
A
1 1 2
4Z9G, 4K5Y
0.33 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51 I
C
1 1 2
5VEX, 5VEW
0.6 0.41 -1.12 1
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Dopamine
Adenosine
AA1R
DRD2
D2
A1
TM6 6x41 L
A
2 2 2
5N2S, 6CM4
0.19 0.21 -1.25
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46 T
A
1 1 4
5XR8, 5U09, 5XRA, 5TGZ
0.01 0.66 0.25 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48 I
A
1 1 2
4Z9G, 4K5Y
0.2 0.41 -1.12
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM2 2x52 A
L
2 1 28
4UHR, 5OLZ, 5IU4, 5NM4, 5OLV, 4UG2, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 2YDV, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 2YDO, 5MZP, 5NLX, 5MZJ, 5N2S, 5IUB, 3UZC, 5OM1
0.06 0 0.50 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36 V
A
1 1 1
5LWE
0.15 0.61 -0.46 2 1 5
Active
Intermediate
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2B
5-HT2B
TM3 3x41 M
W
1 1 8
4IB4, 6DRY, 5TVN, 5TUD, 4NC3, 6DS0, 6DRX, 6DRZ
0.04 0.24 -0.67 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 T
E
1 1 1
5NX2
0.66 0.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48 E
F
1 1 1
5EE7
0.27 0.40 0.11 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x59 I
F
1 1 2
5VEX, 5VEW
0.4 0.41 -1.12
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42 P
A
1 1 1
5NX2
0.93 3.16 0.14
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM7 7x41 T
A
1 1 1
5N2S
0.07 0.66 0.25 6
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61 G
N
1 1 4
6AKY, 4MBS, 5UIW, 6AKX
0.02 1.00 1.15 6
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27 A
L
1 1 18
2VT4, 5A8E, 2YCZ, 4AMJ, 2YCX, 3ZPR, 2Y04, 4GPO, 4AMI, 5F8U, 3ZPQ, 2Y03, 2YCY, 2Y01, 4BVN, 2Y00, 2Y02, 2YCW
0.08 0.11 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42 T
A
1 1 5
5CGD, 5CGC, 6FFI, 6FFH, 4OO9
0.09 0.66 0.25
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67 V
A
1 1 1
5X33
0.02 0.61 -0.46 1
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y12
P2Y1
TM7 7x49 D
N
2 1 5
4XNW, 4NTJ, 4XNV, 4PXZ, 4PY0
0.2 0.69 0.43
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term N
C
2 1 12
5EN0, 2X72, 5W0P, 4BEY, 4ZWJ, 2J4Y, 4BEZ, 4A4M, 6CMO, 3C9M, 5DYS, 5DGY
0.65 0.85
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51 F
A
1 1 2
4Z9G, 4K5Y
0.93 0.54 -1.71 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64 M
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.01 0.24 -0.67 1 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39 R
A
1 1 2
5YQZ, 5EE7
1.0 0.21 1.81 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38 M
A
1 1 1
5LWE
0.04 0.24 -0.67 1
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
ECL2 G
E
A
2 1 2
5NX2, 5EE7
1.00 1.15
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51 D
C
1 1 1
4RWS
0.03 0.69 0.43 16
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36 V
A
1 1 2
4Z9G, 4K5Y
0.07 0.61 -0.46
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48 W
K
1 1 1
5VBL
0.68 0.49 -2.09 Pos & Wild Type AA Match 25
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28 E
Q
2 1 5
2X72, 4ZWJ, 5W0P, 6CMO, 5DGY
0.02 0.57 0.40 0.11 10
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51 Y
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.66 0.53 -0.71 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46 G
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.54 1.00 1.15
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43 M
L
1 1 3
5NDD, 5NJ6, 5NDZ
0.05 0.24 -0.67
Active
Inactive
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54 A
L
1 1 8
4BWB, 4BV0, 5T04, 3ZEV, 4BUO, 4XES, 4XEE, 4GRV
0.04 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM5 5x63 Y
A
1 1 1
5N2S
0.03 0.53 -0.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41 T
A
1 1 1
5LWE
0.09 0.66 0.25
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2 L
F
1 1 1
5NX2
0.21 -1.25
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM5 5x63 L
A
1 1 23
5OLZ, 5IU4, 5NM4, 5OLV, 5IUA, 3PWH, 5OLH, 5OLO, 5OM4, 3REY, 5N2R, 5NM2, 5IU7, 3RFM, 5OLG, 3UZA, 5IU8, 5MZP, 5NLX, 5MZJ, 5IUB, 3UZC, 5OM1
0.13 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53 Y
A
1 1 2
4Z9G, 4K5Y
0.93 0.53 -0.71 Pos & Wild Type AA Match 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33 A
D
1 1 4
6AKY, 4MBS, 5UIW, 6AKX
0.29 0 0.50 2 1 6
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59 V
C
1 1 1
4Z36
0.12 0.61 -0.46 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49 K
E
1 1 4
6AKY, 4MBS, 5UIW, 6AKX
0.13 0.26 2.80 3 1 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39 T
A
1 1 1
5LWE
0.03 0.66 0.25 6
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2 G
M
1 1 5
5CGD, 5CGC, 6FFI, 6FFH, 4OO9
1.00 1.15
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59 R
S
1 1 24
2VT4, 5A8E, 3ZPR, 4GPO, 4AMI, 5F8U, 3ZPQ, 2Y01, 6IBL, 6H7O, 2Y04, 2YCZ, 4AMJ, 6H7N, 2YCX, 6H7J, 6H7M, 2Y03, 2YCY, 4BVN, 6H7L, 2Y00, 2Y02, 2YCW
0.23 0.21 1.81
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x34 F
A
1 1 2
4PHU, 5TZR
0.11 0.54 -1.71 1
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45 C
N
1 1 2
6BQH, 6BQG
0.01 0.68 -0.02 Pos & Wild Type AA Match 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44 W
A
1 1 2
4Z9G, 4K5Y
0.13 0.49 -2.09
Inactive
A (Rhodopsin)
Aminergic
Dopamine
Adrenoceptors
ADRB1
DRD2
β1
D2
TM3 3x40 I
A
V
2 2 3
5A8E, 4BVN, 6CM4