Stabilising Mutation Analyser

Group by: Mutant Subsets: Only show mutations present in minimum 2 GPCRs
STATE TARGETS MUTATIONS FREQUENCY SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS
No. Receptor Families
No. Structures
PDBs Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A
1 1 1
5LWE
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A
1 1 1
5LWE
6
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A
1 1 4
5TZR, 5TZY, 5KW2, 4PHU
2 1 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A
1 1 4
2YDO, 2YDV, 4UG2, 4UHR
9
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM2 2x59
V
I
F
2 1 3
5VEW, 5EE7, 5VEX
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLP1R
GLR
glucagon
GLP-1
CRF1
TM6 6x30
K
Y
A
3 2 5
5VEW, 5EE7, 4K5Y, 4Z9G, 5VEX
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q
2 1 5
5DGY, 5W0P, 2X72, 6CMO, 4ZWJ
10
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A
1 1 5
6FFI, 5CGC, 5CGD, 6FFH, 4OO9
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K
1 1 1
4BVN
8
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A
1 1 2
4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L
1 1 18
2Y00, 4AMJ, 4GPO, 3ZPR, 2Y02, 5A8E, 2YCX, 2Y03, 2Y04, 2YCZ, 2YCY, 5F8U, 4BVN, 3ZPQ, 2Y01, 2VT4, 2YCW, 4AMI
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A
1 1 3
5NDZ, 5NJ6, 5NDD
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM2 2x56
S
A
C
2 1 3
5VEW, 5EE7, 5VEX
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A
1 1 2
4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A
1 1 1
5LWE
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLP1R
GLP-1
CRF1
ECL2 45x52
T
F
A
2 2 3
4K5Y, 4Z9G, 5NX2
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G
1 1 1
5X33
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C
1 1 1
5LWE
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A
1 1 2
4K5Y, 4Z9G
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N
1 1 2
6BQH, 6BQG
Pos Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A
1 1 2
5EE7, 5YQZ
2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM3 3x24
S
G
A
2 1 3
5VEW, 5EE7, 5VEX
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A
1 1 24
2Y00, 4AMJ, 6H7M, 4GPO, 6IBL, 2Y02, 6H7J, 6H7L, 6H7O, 2YCZ, 5F8U, 6H7N, 3ZPQ, 2Y01, 4AMI, 3ZPR, 5A8E, 2YCX, 2Y03, 2Y04, 2YCY, 4BVN, 2VT4, 2YCW
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A
1 1 5
6FFI, 5CGC, 5CGD, 6FFH, 4OO9
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y
1 1 2
5X93, 5XPR
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A
1 1 4
2YDO, 2YDV, 4UG2, 4UHR
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A
1 1 5
6FFI, 5CGC, 5CGD, 6FFH, 4OO9
Pos Match
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A
1 1 3
5NDZ, 5NJ6, 5NDD
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F
1 1 2
5L7I, 5L7D
1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM5 5x63
Y
L
A
2 1 24
3PWH, 5MZJ, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 5OLZ, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 5OLO, 5IUB, 5NLX, 5OLV, 5NM4, 5N2S, 3UZC
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A
1 1 4
5U09, 5TGZ, 5XR8, 5XRA
1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L
1 1 2
5A8E, 4BVN
Pos Match Pos Match 3
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A
1 1 2
4K5Y, 4Z9G
1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C
1 1 2
4QKX, 3PDS
10
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V
1 1 1
5NX2
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CXCR4
CCR9
CXCR4
TM6 6x36
T
V
A
P
2 1 4
4RWS, 5LWE, 3OE9, 3OE0
2 1 5
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM2 2x52
A
L
2 1 28
3PWH, 5MZJ, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 4UG2, 5OLZ, 4UHR, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 2YDV, 5OLO, 5IUB, 5NLX, 5OLV, 5NM4, 5N2S, 3UZC, 2YDO
1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y
2 1 5
5DGY, 4A4M, 5W0P, 6CMO, 4ZWJ
1 1
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLR
glucagon
CRF1
TM2 2x48
A
S
A
L
2 2 3
5EE7, 4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Dopamine
Adenosine
AA2AR
AA1R
DRD2
A2A
A1
D2
TM6 6x41
L
V
A
3 2 25
3PWH, 5MZJ, 6CM4, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 5OLZ, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 5OLO, 5IUB, 5NLX, 5OLV, 5NM4, 5N2S, 3UZC
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E
1 1 3
5NDZ, 5NJ6, 5NDD
5
Active
Inactive
A (Rhodopsin)
Peptide
Aminergic
Endothelin
Adrenoceptors
EDNRB
ADRB1
ETB
β1
TM7 7x48
F
I
A
M
2 2 26
2Y00, 4AMJ, 6H7M, 4GPO, 5XPR, 6IBL, 2Y02, 6H7J, 6H7L, 6H7O, 2YCZ, 5F8U, 6H7N, 3ZPQ, 2Y01, 4AMI, 5X93, 3ZPR, 5A8E, 2YCX, 2Y03, 2Y04, 2YCY, 4BVN, 2VT4, 2YCW
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A
1 1 1
5LWE
4
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
Lysophospholipid (LPA)
LPAR1
CNR1
CB1
LPA1
TM5 5x37
E
D
K
C
2 2 4
5TGZ, 4Z36, 5XR8, 5XRA
1
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Lipid
Adrenoceptors
Free fatty acid
ADRB1
FFAR1
β1
FFA1
TM5 5x58
Y
A
F
2 2 22
2Y00, 5TZR, 4AMJ, 4GPO, 2Y02, 2YCZ, 5F8U, 3ZPQ, 2Y01, 5TZY, 4AMI, 4PHU, 3ZPR, 5A8E, 2YCX, 2Y03, 2Y04, 2YCY, 4BVN, 2VT4, 2YCW, 5KW2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM7 7x41
T
S
A
2 1 24
3PWH, 5MZJ, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 5OLZ, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 5OLO, 5IUB, 5NLX, 5OLV, 5NM4, 5N2S, 3UZC
6
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A
1 1 2
4K5Y, 4Z9G
Intermediate
Inactive
A (Rhodopsin)
Peptide
Aminergic
Nucleotide
Neurotensin
Adenosine
Dopamine
AA2AR
AA1R
DRD2
NTR1
D2
A2A
A1
NTS1
TM6 6x37
L
A
4 3 26
3PWH, 5MZJ, 6CM4, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 5OLZ, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 5OLO, 5IUB, 5NLX, 4GRV, 5NM4, 5OLV, 5N2S, 3UZC
1 1 4
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A
1 1 1
5EE7
Intermediate
A (Rhodopsin)
Peptide
Lipid
Proteinase-activated
Free fatty acid
PAR2
FFAR1
PAR2
FFA1
TM3 3x34
F
G
A
2 2 5
5NDZ, 5TZR, 5NJ6, 4PHU, 5NDD
1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A
1 1 2
4K5Y, 4Z9G
Pos Match 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N
1 1 1
5WF5
Pos Match 1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V
1 1 24
2Y00, 4AMJ, 6H7M, 4GPO, 6IBL, 2Y02, 6H7J, 6H7L, 6H7O, 2YCZ, 5F8U, 6H7N, 3ZPQ, 2Y01, 4AMI, 3ZPR, 5A8E, 2YCX, 2Y03, 2Y04, 2YCY, 4BVN, 2VT4, 2YCW
2
Intermediate
A (Rhodopsin)
Peptide
Lipid
Neurotensin
Free fatty acid
NTR1
FFAR1
NTS1
FFA1
TM3 3x49
E
G
A
2 2 6
5TZR, 4GRV, 4XES, 5TZY, 5KW2, 4PHU
Pos Match 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C
1 1 2
5VEW, 5VEX
1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M
1 1 5
6FFI, 5CGC, 5CGD, 6FFH, 4OO9
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L
1 1 3
5NDZ, 5NJ6, 5NDD
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A
1 1 2
5VEW, 5VEX
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K
1 1 1
5VBL
Pos Match 25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N
1 1 4
6AKY, 5UIW, 6AKX, 4MBS
6
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y
1 1 5
6FFI, 5CGC, 5CGD, 6FFH, 4OO9
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A
1 1 23
3PWH, 5MZJ, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 5OLZ, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 5OLO, 5IUB, 5NLX, 5OLV, 5NM4, 3UZC
1 2
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A
1 1 1
5WF6
Pos Match 1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S
1 1 24
2Y00, 4AMJ, 6H7M, 4GPO, 6IBL, 2Y02, 6H7J, 6H7L, 6H7O, 2YCZ, 5F8U, 6H7N, 3ZPQ, 2Y01, 4AMI, 3ZPR, 5A8E, 2YCX, 2Y03, 2Y04, 2YCY, 4BVN, 2VT4, 2YCW
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C
1 1 2
5VEW, 5VEX
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2RY1
P2Y12
P2Y12
P2Y1
TM7 7x49
D
N
2 1 5
4XNV, 4PY0, 4XNW, 4NTJ, 4PXZ
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C
1 1 1
4RWS
16
Intermediate
Active
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L
1 1 8
4GRV, 5T04, 4XEE, 4XES, 4BUO, 3ZEV, 4BV0, 4BWB
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A
1 1 3
5NDZ, 5NJ6, 5NDD
1 3
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I
1 1 2
5EN0, 5DYS
19
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A
1 1 1
5NX2
2 2
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A
1 1 4
4BWB, 3ZEV, 4BV0, 4BUO
Intermediate
Active
Inactive
A (Rhodopsin)
Aminergic
Protein
Dopamine
Chemokine
Adrenoceptors
5-Hydroxytryptamine
ADRB2
DRD3
ADRB1
CXCR4
5HT1B
5HT2B
5-HT1B
β1
D3
β2
CXCR4
5-HT2B
TM3 3x41
E
L
M
W
6 4 24
3NY8, 6DRX, 6DRZ, 5TVN, 5V54, 6G79, 3ODU, 4IAQ, 4RWS, 4IAR, 3D4S, 6DRY, 5TUD, 3OE0, 6DS0, 3OE6, 5A8E, 3PBL, 4IB4, 3NY9, 3OE9, 4NC3, 3OE8, 3NYA
1
Inactive
A (Rhodopsin)
Peptide
Aminergic
Dopamine
Apelin
Adrenoceptors
ADRB1
DRD2
APJ
apelin
β1
D2
TM3 3x40
V
I
A
V
3 3 4
5A8E, 4BVN, 6CM4, 5VBL
2
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A
C
1 1 3
5VEW, 5NX2, 5VEX
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A
1 1 3
5NDZ, 5NJ6, 5NDD
1 1 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A
1 1 1
5LWE
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A
1 1 3
5NDZ, 5NJ6, 5NDD
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A
1 1 1
5LWE
1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A
1 1 3
5NDZ, 5NJ6, 5NDD
1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A
1 1 2
4K5Y, 4Z9G
1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A
1 1 1
5X93
1
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C
1 1 1
4Z36
4
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G
1 1 1
5X33
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F
1 1 1
5EE7
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A
1 1 1
5EE7
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I
1 1 2
5VEW, 5VEX
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A
1 1 1
5X33
1
Intermediate
Active
Inactive
A (Rhodopsin)
Lipid
Peptide
Sensory
Neurotensin
Leukotriene
Opsins
OPSD
Q9WTK1
OPSD
NTR1
BLT1
Rhodopsin
NTS1
ECL2
N
D
S
G
A
C
4 3 17
5DGY, 5T04, 4BEY, 4XEE, 5DYS, 4XES, 5EN0, 5X33, 2J4Y, 3C9M, 4ZWJ, 4GRV, 4A4M, 2X72, 6CMO, 4BEZ, 5W0P
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A
1 1 1
5EE7
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A
1 1 2
5X93, 5XPR
2
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
ECL1
T
L
G
D
Q
A
E
F
R
2 1 2
5EE7, 5NX2
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E
1 1 3
5TGZ, 5XR8, 5XRA
1 5
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A
1 1 2
5X93, 5XPR
4
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM3 3x36
T
A
2 1 24
3PWH, 5MZJ, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 5OLZ, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 5OLO, 5IUB, 5NLX, 5OLV, 5NM4, 5N2S, 3UZC
20
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A
1 1 5
6FFI, 5CGC, 5CGD, 6FFH, 4OO9
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y
1 1 4
6AKY, 5UIW, 6AKX, 4MBS
2
Intermediate
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A
1 1 4
5T04, 4GRV, 4XEE, 4XES
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E
1 1 4
6AKY, 5UIW, 6AKX, 4MBS
3 1 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F
1 1 2
5VEW, 5VEX
1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A
1 1 23
3PWH, 5MZJ, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 5OLZ, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 5OLO, 5IUB, 5NLX, 5OLV, 5NM4, 3UZC
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D
1 1 4
6AKY, 5UIW, 6AKX, 4MBS
2 1 6
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A
1 1 2
4K5Y, 4Z9G
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A
1 1 4
2YDO, 2YDV, 4UG2, 4UHR
STATE TARGETS MUTATIONS FREQUENCY DATA (MUTANT) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A 1 1 4
2YDO, 2YDV, 4UG2, 4UHR
0.13 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L 1 1 2
5A8E, 4BVN
0.03 0.21 -1.25 Pos Match (But Not Mutant AA) Pos & Mutant AA Match 3
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y 2 1 5
5DGY, 4A4M, 5W0P, 6CMO, 4ZWJ
0.01 0.53 -0.71 1 1
Intermediate
Active
Inactive
A (Rhodopsin)
Aminergic
Protein
Dopamine
Chemokine
Adrenoceptors
5-Hydroxytryptamine
ADRB2
DRD3
ADRB1
CXCR4
5HT1B
5HT2B
5-HT1B
β1
D3
β2
CXCR4
5-HT2B
TM3 3x41
E
L
M
W 6 4 24
3NY8, 6DRX, 6DRZ, 5TVN, 5V54, 6G79, 3ODU, 4IAQ, 4RWS, 4IAR, 3D4S, 6DRY, 5TUD, 3OE0, 6DS0, 3OE6, 5A8E, 3PBL, 4IB4, 3NY9, 3OE9, 4NC3, 3OE8, 3NYA
0.03 0.49 -2.09 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y 1 1 2
5X93, 5XPR
0.09 0.53 -0.71
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A 1 1 5
6FFI, 5CGC, 5CGD, 6FFH, 4OO9
0.05 0 0.50
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N 1 1 2
6BQH, 6BQG
0.67 0.65 0.85 Pos & AA Mutant Match 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A 1 1 3
5NDZ, 5NJ6, 5NDD
0.0 0 0.50 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A 1 1 1
5WF6
0.03 0 0.50 Pos & AA Mutant Match 1
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLP1R
GLP-1
CRF1
ECL2 45x52
T
F
A 2 2 3
4K5Y, 4Z9G, 5NX2
0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2RY1
P2Y12
P2Y12
P2Y1
TM7 7x49
D
N 2 1 5
4XNV, 4PY0, 4XNW, 4NTJ, 4PXZ
0.72 0.65 0.85
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48
A
L 1 1 1
5EE7
0.2 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLP1R
GLR
glucagon
GLP-1
CRF1
TM6 6x30
K
Y
A 3 2 5
5VEW, 5EE7, 4K5Y, 4Z9G, 5VEX
0 0.50
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q 2 1 5
5DGY, 5W0P, 2X72, 6CMO, 4ZWJ
0.01 0.39 0.77 10
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I 1 1 2
5EN0, 5DYS
0.03 0.29 0.41 -1.12 19
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A 1 1 24
2Y00, 4AMJ, 6H7M, 4GPO, 6IBL, 2Y02, 6H7J, 6H7L, 6H7O, 2YCZ, 5F8U, 6H7N, 3ZPQ, 2Y01, 4AMI, 3ZPR, 5A8E, 2YCX, 2Y03, 2Y04, 2YCY, 4BVN, 2VT4, 2YCW
0.1 0.11 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM3 3x36
T
A 2 1 24
3PWH, 5MZJ, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 5OLZ, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 5OLO, 5IUB, 5NLX, 5OLV, 5NM4, 5N2S, 3UZC
0.02 0 0.50 20
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37
D
C 1 1 1
4Z36
0.68 -0.02 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E 1 1 3
5TGZ, 5XR8, 5XRA
0.04 0.40 0.11 1 5
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A 1 1 2
5EE7, 5YQZ
0 0.50 2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48
S
A 1 1 2
4K5Y, 4Z9G
0.2 0 0.50
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S 1 1 24
2Y00, 4AMJ, 6H7M, 4GPO, 6IBL, 2Y02, 6H7J, 6H7L, 6H7O, 2YCZ, 5F8U, 6H7N, 3ZPQ, 2Y01, 4AMI, 3ZPR, 5A8E, 2YCX, 2Y03, 2Y04, 2YCY, 4BVN, 2VT4, 2YCW
0.04 0.50 0.46
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A 1 1 1
5EE7
0.27 0 0.50
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
ECL1
T
G
E 2 1 2
5EE7, 5NX2
0.40 0.11
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D 1 1 4
6AKY, 5UIW, 6AKX, 4MBS
0.69 0.43 2 1 6
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A 1 1 2
4K5Y, 4Z9G
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A 1 1 1
5NX2
0.07 0 0.50 2 2
Intermediate
Inactive
A (Rhodopsin)
Peptide
Aminergic
Nucleotide
Neurotensin
Adenosine
Dopamine
AA2AR
AA1R
DRD2
NTR1
D2
A2A
A1
NTS1
TM6 6x37
L
A 4 3 26
3PWH, 5MZJ, 6CM4, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 5OLZ, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 5OLO, 5IUB, 5NLX, 4GRV, 5NM4, 5OLV, 5N2S, 3UZC
0.04 0 0.50 1 1 4
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F 1 1 1
5NX2
0.4 0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A 1 1 2
4K5Y, 4Z9G
0.07 0 0.50
Intermediate
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A 1 1 4
5T04, 4GRV, 4XEE, 4XES
0.19 0 0.50
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A 1 1 4
5U09, 5TGZ, 5XR8, 5XRA
0.01 0 0.50 1
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37
E
K 1 1 3
5TGZ, 5XR8, 5XRA
0.11 0.26 2.80 1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48
F
M 1 1 24
2Y00, 4AMJ, 6H7M, 4GPO, 6IBL, 2Y02, 6H7J, 6H7L, 6H7O, 2YCZ, 5F8U, 6H7N, 3ZPQ, 2Y01, 4AMI, 3ZPR, 5A8E, 2YCX, 2Y03, 2Y04, 2YCY, 4BVN, 2VT4, 2YCW
0.05 0.24 -0.67
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A 1 1 1
5LWE
0.14 0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N 1 1 1
5WF5
0.03 0.65 0.85 Pos & AA Mutant Match 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V 1 1 1
5NX2
0.61 -0.46 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A 1 1 1
5EE7
0.07 0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A 1 1 1
5X93
0.08 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y 1 1 5
6FFI, 5CGC, 5CGD, 6FFH, 4OO9
0.05 0.53 -0.71
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A 1 1 4
2YDO, 2YDV, 4UG2, 4UHR
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM3 3x24
S
G
A 2 1 3
5VEW, 5EE7, 5VEX
0.07 0 0.50
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM2 2x52
A
L 2 1 28
3PWH, 5MZJ, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 4UG2, 5OLZ, 4UHR, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 2YDV, 5OLO, 5IUB, 5NLX, 5OLV, 5NM4, 5N2S, 3UZC, 2YDO
0.63 0.21 -1.25 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2
L
F 1 1 1
5NX2
0.54 -1.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E 1 1 4
6AKY, 5UIW, 6AKX, 4MBS
0.12 0.40 0.11 3 1 2
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C 1 1 1
4Z36
0.01 0.68 -0.02 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A 1 1 1
5LWE
0.08 0 0.50 6
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A 1 1 3
5NDZ, 5NJ6, 5NDD
0.11 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M 1 1 5
6FFI, 5CGC, 5CGD, 6FFH, 4OO9
0.24 -0.67
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A 1 1 1
5LWE
0.06 0 0.50 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G 1 1 1
5X33
0.67 1.00 1.15 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A 1 1 1
5X33
0.08 0 0.50 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A 1 1 3
5NDZ, 5NJ6, 5NDD
0.13 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM5 5x63
Y
L
A 2 1 24
3PWH, 5MZJ, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 5OLZ, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 5OLO, 5IUB, 5NLX, 5OLV, 5NM4, 5N2S, 3UZC
0.06 0 0.50
Intermediate
Active
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L 1 1 8
4GRV, 5T04, 4XEE, 4XES, 4BUO, 3ZEV, 4BV0, 4BWB
0.37 0.21 -1.25
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A 1 1 1
5NX2
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A 1 1 3
5NDZ, 5NJ6, 5NDD
0.13 0 0.50 1 3
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V 1 1 24
2Y00, 4AMJ, 6H7M, 4GPO, 6IBL, 2Y02, 6H7J, 6H7L, 6H7O, 2YCZ, 5F8U, 6H7N, 3ZPQ, 2Y01, 4AMI, 3ZPR, 5A8E, 2YCX, 2Y03, 2Y04, 2YCY, 4BVN, 2VT4, 2YCW
0.23 0.33 0.61 -0.46 2
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F 1 1 2
5L7I, 5L7D
0.54 -1.71 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A 1 1 1
5LWE
0.07 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM7 7x41
T
S
A 2 1 24
3PWH, 5MZJ, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 5OLZ, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 5OLO, 5IUB, 5NLX, 5OLV, 5NM4, 5N2S, 3UZC
0.38 0 0.50 6
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L 1 1 18
2Y00, 4AMJ, 4GPO, 3ZPR, 2Y02, 5A8E, 2YCX, 2Y03, 2Y04, 2YCZ, 2YCY, 5F8U, 4BVN, 3ZPQ, 2Y01, 2VT4, 2YCW, 4AMI
0.11 0.11 0.21 -1.25
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A 1 1 2
5X93, 5XPR
0.1 0 0.50 4
Intermediate
Active
Inactive
A (Rhodopsin)
Peptide
Lipid
Neurotensin
Leukotriene
Q9WTK1
NTR1
BLT1
NTS1
ECL2
S
G
A 2 2 5
5X33, 5T04, 4GRV, 4XEE, 4XES
0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K 1 1 1
4BVN
0.04 0.11 0.26 2.80 8
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A 1 1 4
4BWB, 3ZEV, 4BV0, 4BUO
0.02 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x56
S
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A 1 1 23
3PWH, 5MZJ, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 5OLZ, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 5OLO, 5IUB, 5NLX, 5OLV, 5NM4, 3UZC
0.08 0 0.50 1 2
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM3 3x40
I
V 1 1 2
5A8E, 4BVN
0.24 0.61 -0.46 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C 1 1 2
5VEW, 5VEX
0.68 -0.02 1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C 1 1 2
4QKX, 3PDS
0.0 0.68 -0.02 10
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L 1 1 3
5NDZ, 5NJ6, 5NDD
0.73 0.21 -1.25
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A 1 1 2
5X93, 5XPR
0.07 0 0.50 2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A 1 1 3
5NDZ, 5NJ6, 5NDD
0.05 0 0.50 1 1 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM2 2x59
V
I
F 2 1 3
5VEW, 5EE7, 5VEX
0.54 -1.71
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A 1 1 5
6FFI, 5CGC, 5CGD, 6FFH, 4OO9
0.05 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Dopamine
Adenosine
AA2AR
AA1R
DRD2
A2A
A1
D2
TM6 6x41
L
V
A 3 2 25
3PWH, 5MZJ, 6CM4, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 5OLZ, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 5OLO, 5IUB, 5NLX, 5OLV, 5NM4, 5N2S, 3UZC
0.05 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C 1 1 1
4RWS
0.68 -0.02 16
Inactive
A (Rhodopsin)
Peptide
Aminergic
Dopamine
Apelin
DRD2
APJ
apelin
D2
TM3 3x40
V
I
A 2 2 2
6CM4, 5VBL
0.06 0 0.50 2
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K 1 1 1
5VBL
0.26 2.80 Pos Match (But Not Mutant AA) 25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N 1 1 4
6AKY, 5UIW, 6AKX, 4MBS
0.03 0.65 0.85 6
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term
D
N
C 2 1 12
5DGY, 4BEY, 5DYS, 5EN0, 2J4Y, 3C9M, 4ZWJ, 4A4M, 2X72, 6CMO, 4BEZ, 5W0P
0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A 1 1 2
4K5Y, 4Z9G
0 0.50 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I 1 1 2
5VEW, 5VEX
0.07 0.41 -1.12
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36
V
A 1 1 1
5LWE
0.02 0 0.50 2 1 5
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
Q
G
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A 1 1 2
4K5Y, 4Z9G
0 0.50 Pos & Mutant AA Match 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A 1 1 2
4K5Y, 4Z9G
0 0.50
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM5 5x58
Y
F 1 1 4
5TZR, 5TZY, 5KW2, 4PHU
0.01 0.54 -1.71
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E 1 1 3
5NDZ, 5NJ6, 5NDD
0.01 0.40 0.11 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C 1 1 1
5LWE
0.02 0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F 1 1 1
5EE7
0.13 0.54 -1.71 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
D
R 1 1 1
5NX2
0.21 1.81
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F 1 1 2
5VEW, 5VEX
0.07 0.54 -1.71 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A 1 1 1
5LWE
0.03 0 0.50 4
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A 1 1 4
2YDO, 2YDV, 4UG2, 4UHR
0.03 0 0.50 9
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x56
S
A 1 1 1
5EE7
0.27 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A 1 1 5
6FFI, 5CGC, 5CGD, 6FFH, 4OO9
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A 1 1 1
5NX2
0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48
I
A 1 1 2
5X93, 5XPR
0.13 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36
T
P 1 1 3
4RWS, 3OE9, 3OE0
0.0 3.16 0.14 2 1 5
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A 1 1 23
3PWH, 5MZJ, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 5OLZ, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 5OLO, 5IUB, 5NLX, 5OLV, 5NM4, 3UZC
0.13 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A 1 1 1
5LWE
0.12 0 0.50 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A 1 1 2
4K5Y, 4Z9G
0 0.50 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G 1 1 1
5X33
0.25 1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A 1 1 2
5VEW, 5VEX
0.07 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Lipid
Proteinase-activated
Free fatty acid
PAR2
FFAR1
PAR2
FFA1
TM3 3x34
F
G
A 2 2 5
5NDZ, 5TZR, 5NJ6, 4PHU, 5NDD
0.07 0 0.50 1
Intermediate
A (Rhodopsin)
Peptide
Lipid
Neurotensin
Free fatty acid
NTR1
FFAR1
NTS1
FFA1
TM3 3x49
E
G
A 2 2 6
5TZR, 4GRV, 4XES, 5TZY, 5KW2, 4PHU
0.01 0 0.50 Pos & Mutant AA Match 2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A 1 1 3
5NDZ, 5NJ6, 5NDD
0.14 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y 1 1 4
6AKY, 5UIW, 6AKX, 4MBS
0.07 0.53 -0.71 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A 1 1 1
5EE7
0.33 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM5 5x58
Y
A 1 1 18
2Y00, 4AMJ, 4GPO, 3ZPR, 2Y02, 5A8E, 2YCX, 2Y03, 2Y04, 2YCZ, 2YCY, 5F8U, 4BVN, 3ZPQ, 2Y01, 2VT4, 2YCW, 4AMI
0.03 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A 1 1 5
6FFI, 5CGC, 5CGD, 6FFH, 4OO9
0 0.50 Pos & Mutant AA Match
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A 1 1 4
5TZR, 5TZY, 5KW2, 4PHU
0.06 0 0.50 2 1 1
STATE TARGETS MUTATIONS FREQUENCY DATA (WILD TYPE) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2 L
F
1 1 1
5NX2
0.21 -1.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39 T
A
1 1 1
5LWE
0.03 0.66 0.25 6
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term N
C
2 1 12
5DGY, 4BEY, 5DYS, 5EN0, 2J4Y, 3C9M, 4ZWJ, 4A4M, 2X72, 6CMO, 4BEZ, 5W0P
0.65 0.85
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42 T
A
1 1 5
6FFI, 5CGC, 5CGD, 6FFH, 4OO9
0.09 0.66 0.25
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM2 2x52 A
L
2 1 28
3PWH, 5MZJ, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 4UG2, 5OLZ, 4UHR, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 2YDV, 5OLO, 5IUB, 5NLX, 5OLV, 5NM4, 5N2S, 3UZC, 2YDO
0.06 0 0.50 1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48 F
M
1 1 24
2Y00, 4AMJ, 6H7M, 4GPO, 6IBL, 2Y02, 6H7J, 6H7L, 6H7O, 2YCZ, 5F8U, 6H7N, 3ZPQ, 2Y01, 4AMI, 3ZPR, 5A8E, 2YCX, 2Y03, 2Y04, 2YCY, 4BVN, 2VT4, 2YCW
0.06 0.33 0.54 -1.71
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37 H
A
1 1 3
5NDZ, 5NJ6, 5NDD
0.03 0.61 0.11 1 1 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53 Y
A
1 1 2
4K5Y, 4Z9G
0.93 0.53 -0.71 Pos & Wild Type AA Match 1
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46 T
A
1 1 4
5U09, 5TGZ, 5XR8, 5XRA
0.01 0.66 0.25 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60 C
Y
1 1 4
6AKY, 5UIW, 6AKX, 4MBS
0.02 0.68 -0.02 2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51 F
A
1 1 2
4K5Y, 4Z9G
0.93 0.54 -1.71 1
Intermediate
Inactive
A (Rhodopsin)
Peptide
Aminergic
Nucleotide
Neurotensin
Adenosine
Dopamine
AA2AR
AA1R
DRD2
NTR1
D2
A2A
A1
NTS1
TM6 6x37 L
A
4 3 26
3PWH, 5MZJ, 6CM4, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 5OLZ, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 5OLO, 5IUB, 5NLX, 4GRV, 5NM4, 5OLV, 5N2S, 3UZC
0.38 0.21 -1.25 1 1 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36 T
P
1 1 3
4RWS, 3OE9, 3OE0
0.25 0.66 0.25 2 1 5
Intermediate
Active
Inactive
A (Rhodopsin)
Protein
Aminergic
Dopamine
Chemokine
5-Hydroxytryptamine
5HT1B
DRD3
CXCR4
5-HT1B
CXCR4
D3
TM3 3x41 L
W
3 3 11
3OE0, 3OE6, 3PBL, 5V54, 6G79, 3ODU, 3OE9, 3OE8, 4IAQ, 4RWS, 4IAR
0.31 0.21 -1.25 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33 A
D
1 1 4
6AKY, 5UIW, 6AKX, 4MBS
0.29 0 0.50 2 1 6
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38 I
A
1 1 3
5NDZ, 5NJ6, 5NDD
0.08 0.41 -1.12
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31 L
F
1 1 1
5NX2
0.2 0.21 -1.25
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40 M
Y
2 1 5
5DGY, 4A4M, 5W0P, 6CMO, 4ZWJ
0.05 0.71 0.24 -0.67 1 1
Intermediate
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43 V
A
1 1 4
5T04, 4GRV, 4XEE, 4XES
0.1 0.61 -0.46
Intermediate
Active
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
ECL2 G
A
1 1 4
5T04, 4GRV, 4XEE, 4XES
1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32 M
C
1 1 2
5VEW, 5VEX
0.13 0.24 -0.67
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
ECL2 G
A
E
2 1 2
5EE7, 5NX2
1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48 E
F
1 1 1
5EE7
0.27 0.40 0.11 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36 V
A
1 1 1
5LWE
0.15 0.61 -0.46 2 1 5
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 D
R
1 1 1
5NX2
0.69 0.43
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM7 7x41 S
A
1 1 23
3PWH, 5MZJ, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 5OLZ, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 5OLO, 5IUB, 5NLX, 5OLV, 5NM4, 3UZC
0.16 0.50 0.46 6
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54 I
A
1 1 4
4BWB, 3ZEV, 4BV0, 4BUO
0.33 0.41 -1.12
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
ADRB1
β2
β1
TM3 3x41 E
W
2 1 5
3NY8, 5A8E, 3NY9, 3NYA, 3D4S
0.01 0.33 0.40 0.11 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53 V
E
1 1 3
5NDZ, 5NJ6, 5NDD
0.07 0.61 -0.46 5
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46 G
A
1 1 3
5NDZ, 5NJ6, 5NDD
0.54 1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48 A
L
1 1 1
5EE7
0.2 0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2RY1
P2Y12
P2Y12
P2Y1
TM7 7x49 D
N
2 1 5
4XNV, 4PY0, 4XNW, 4NTJ, 4PXZ
0.2 0.69 0.43
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51 I
C
1 1 2
5VEW, 5VEX
0.6 0.41 -1.12 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2 G
M
1 1 5
6FFI, 5CGC, 5CGD, 6FFH, 4OO9
1.00 1.15
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x34 G
A
1 1 3
5NDZ, 5NJ6, 5NDD
0.02 1.00 1.15 1
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM3 3x49 E
A
1 1 2
4GRV, 4XES
0.21 0.40 0.11 Pos & Wild Type AA Match 2
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37 E
K
1 1 3
5TGZ, 5XR8, 5XRA
0.03 0.40 0.11 1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63 H
C
1 1 2
4QKX, 3PDS
0.03 0.11 0.61 0.11 10
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54 S
A
1 1 2
5X93, 5XPR
0.05 0.50 0.46 4
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32 R
E
1 1 3
5TGZ, 5XR8, 5XRA
0.31 0.21 1.81 1 5
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM6 6x41 V
A
1 1 23
3PWH, 5MZJ, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 5OLZ, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 5OLO, 5IUB, 5NLX, 5OLV, 5NM4, 3UZC
0.41 0.61 -0.46
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL2 45x52 T
A
1 1 1
5NX2
0.2 0.66 0.25
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50 I
A
1 1 5
6FFI, 5CGC, 5CGD, 6FFH, 4OO9
0.5 0.41 -1.12 Pos & Wild Type AA Match
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27 A
L
1 1 18
2Y00, 4AMJ, 4GPO, 3ZPR, 2Y02, 5A8E, 2YCX, 2Y03, 2Y04, 2YCZ, 2YCY, 5F8U, 4BVN, 3ZPQ, 2Y01, 2VT4, 2YCW, 4AMI
0.08 0.11 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x30 Y
A
1 1 2
4K5Y, 4Z9G
0.73 0.53 -0.71
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
ECL3 D
C
1 1 8
4BEY, 5DYS, 2X72, 4A4M, 4BEZ, 5EN0, 2J4Y, 3C9M
0.69 0.43
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51 Y
A
1 1 3
5NDZ, 5NJ6, 5NDD
0.66 0.53 -0.71 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48 S
A
1 1 2
5VEW, 5VEX
0.07 0.50 0.46
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43 K
A
1 1 23
3PWH, 5MZJ, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 5OLZ, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 5OLO, 5IUB, 5NLX, 5OLV, 5NM4, 3UZC
0.16 0.26 2.80
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40 L
A
1 1 4
5TZR, 5TZY, 5KW2, 4PHU
0.03 0.21 -1.25 2 1 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42 P
A
1 1 1
5NX2
0.93 3.16 0.14
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48 N
Y
1 1 5
6FFI, 5CGC, 5CGD, 6FFH, 4OO9
0.41 0.65 0.85
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43 K
A
1 1 2
4K5Y, 4Z9G
0.13 0.26 2.80
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59 V
C
1 1 1
4Z36
0.12 0.61 -0.46 4
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 Q
A
1 1 1
5NX2
0.39 0.77
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM5 5x63 L
A
1 1 23
3PWH, 5MZJ, 5IUA, 5OLG, 5IU4, 3UZA, 5OM4, 5IU8, 3RFM, 5OM1, 5OLZ, 5IU7, 5N2R, 5MZP, 5OLH, 3REY, 5NM2, 5OLO, 5IUB, 5NLX, 5OLV, 5NM4, 3UZC
0.13 0.21 -1.25
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
C-term S
A
1 1 1
5X33
0.50 0.46
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39 F
A
1 1 1
5EE7
0.33 0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38 S
A
1 1 2
4K5Y, 4Z9G
0.13 0.50 0.46 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42 L
A
1 1 3
5NDZ, 5NJ6, 5NDD
0.24 0.21 -1.25
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37 Q
A
1 1 4
2YDO, 2YDV, 4UG2, 4UHR
0.02 0.39 0.77 9
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59 R
S
1 1 24
2Y00, 4AMJ, 6H7M, 4GPO, 6IBL, 2Y02, 6H7J, 6H7L, 6H7O, 2YCZ, 5F8U, 6H7N, 3ZPQ, 2Y01, 4AMI, 3ZPR, 5A8E, 2YCX, 2Y03, 2Y04, 2YCY, 4BVN, 2VT4, 2YCW
0.23 0.21 1.81
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48 G
A
1 1 1
5EE7
0.13 1.00 1.15
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60 T
I
1 1 2
5EN0, 5DYS
0.08 0.43 0.66 0.25 19
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Dopamine
Adenosine
AA1R
DRD2
A1
D2
TM6 6x41 L
A
2 2 2
5N2S, 6CM4
0.19 0.21 -1.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50 V
A
1 1 1
5LWE
0.02 0.61 -0.46 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47 H
V
1 1 1
5NX2
0.73 0.61 0.11 1
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Lipid
Adrenoceptors
Free fatty acid
ADRB1
FFAR1
β1
FFA1
TM5 5x58 Y
A
F
2 2 22
2Y00, 5TZR, 4AMJ, 4GPO, 2Y02, 2YCZ, 5F8U, 3ZPQ, 2Y01, 5TZY, 4AMI, 4PHU, 3ZPR, 5A8E, 2YCX, 2Y03, 2Y04, 2YCY, 4BVN, 2VT4, 2YCW, 5KW2
0.71 0.53 -0.71
Inactive
A (Rhodopsin)
Aminergic
Dopamine
Adrenoceptors
ADRB1
DRD2
β1
D2
TM3 3x40 I
A
V
2 2 3
4BVN, 6CM4, 5A8E
0.4 0.41 -1.12 2
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55 R
Y
1 1 2
5X93, 5XPR
0.02 0.21 1.81
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31 D
K
1 1 1
4BVN
0.1 0.22 0.69 0.43 8
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36 F
A
1 1 24
2Y00, 4AMJ, 6H7M, 4GPO, 6IBL, 2Y02, 6H7J, 6H7L, 6H7O, 2YCZ, 5F8U, 6H7N, 3ZPQ, 2Y01, 4AMI, 3ZPR, 5A8E, 2YCX, 2Y03, 2Y04, 2YCY, 4BVN, 2VT4, 2YCW
0.14 0.44 0.54 -1.71
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39 S
A
1 1 1
5WF6
0.72 0.50 0.46 Pos & Wild Type AA Match 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67 V
A
1 1 1
5X33
0.02 0.61 -0.46 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50 D
N
1 1 1
5WF5
0.92 0.69 0.43 Pos & Wild Type AA Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x24 S
A
1 1 2
5VEW, 5VEX
0.27 0.50 0.46
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48 W
K
1 1 1
5VBL
0.68 0.49 -2.09 Pos & Wild Type AA Match 25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39 R
A
1 1 2
5EE7, 5YQZ
1.0 0.21 1.81 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM6 6x30 K
A
2 1 3
5VEW, 5EE7, 5VEX
0.2 0.26 2.80
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48 I
A
1 1 2
5X93, 5XPR
0.15 0.41 -1.12
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM3 3x24 G
A
1 1 1
5EE7
0.4 1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM2 2x56 S
A
C
2 1 3
5VEW, 5EE7, 5VEX
0.47 0.50 0.46
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x59 I
F
1 1 2
5VEW, 5VEX
0.4 0.41 -1.12
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM3 3x40 V
A
1 1 1
5VBL
0.24 0.61 -0.46 2
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62 T
A
1 1 4
2YDO, 2YDV, 4UG2, 4UHR
0.1 0.66 0.25
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40 V
F
1 1 2
5L7I, 5L7D
0.09 0.09 0.61 -0.46 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51 D
C
1 1 1
4RWS
0.03 0.69 0.43 16
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45 G
A
C
1 1 3
5VEW, 5NX2, 5VEX
1.0 1.00 1.15
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29 N
A
1 1 1
5LWE
0.03 0.65 0.85
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48 S
A
1 1 2
4K5Y, 4Z9G
0.07 0.50 0.46
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43 M
L
1 1 3
5NDZ, 5NJ6, 5NDD
0.05 0.24 -0.67
Intermediate
Active
Inactive
A (Rhodopsin)
Peptide