Stabilising Mutation Analyser

Group by: Mutant Subsets: Only show mutations present in minimum 2 GPCRs
STATE TARGETS MUTATIONS FREQUENCY SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS
No. Receptor Families
No. Structures
PDBs Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM3 3x36
T
A
2 1 24
5IUA, 5N2R, 5OLG, 5OM1, 5NLX, 5N2S, 5OLH, 5NM4, 5IUB, 3UZA, 5MZP, 5IU7, 5OLV, 5IU8, 3UZC, 5NM2, 5IU4, 3REY, 3RFM, 3PWH, 5OLO, 5MZJ, 5OLZ, 5OM4
23
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S
1 1 24
2Y02, 6H7N, 2Y03, 6H7L, 3ZPQ, 4GPO, 2Y01, 4AMI, 6H7O, 2YCY, 3ZPR, 6H7J, 6H7M, 4AMJ, 2YCW, 2YCX, 5A8E, 2VT4, 5F8U, 6IBL, 2YCZ, 2Y04, 4BVN, 2Y00
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V
1 1 24
2Y02, 6H7N, 2Y03, 6H7L, 3ZPQ, 4GPO, 2Y01, 4AMI, 6H7O, 2YCY, 3ZPR, 6H7J, 6H7M, 4AMJ, 2YCW, 2YCX, 5A8E, 2VT4, 5F8U, 6IBL, 2YCZ, 2Y04, 4BVN, 2Y00
2
Inactive
A (Rhodopsin)
Peptide
Aminergic
Dopamine
Adrenoceptors
Apelin
DRD2
ADRB1
APJ
D2
β1
apelin
TM3 3x40
I
V
V
A
3 3 4
5A8E, 6CM4, 4BVN, 5VBL
2
Inactive
Active
Intermediate
A (Rhodopsin)
Aminergic
Protein
5-Hydroxytryptamine
Adrenoceptors
Dopamine
Chemokine
ADRB2
ADRB1
DRD3
CXCR4
5HT1B
5HT2B
CXCR4
β2
5-HT1B
5-HT2B
D3
β1
TM3 3x41
M
L
E
W
6 4 24
3NYA, 6G79, 3OE6, 4RWS, 5TUD, 3ODU, 3OE0, 3OE9, 4IB4, 6DS0, 6DRY, 5TVN, 5A8E, 6DRZ, 3D4S, 4IAR, 5V54, 6DRX, 4IAQ, 3NY9, 3NY8, 3OE8, 4NC3, 3PBL
1
Inactive
Intermediate
A (Rhodopsin)
Lipid
Aminergic
Adrenoceptors
Free fatty acid
ADRB1
FFAR1
FFA1
β1
TM5 5x58
Y
F
A
2 2 22
2Y02, 2Y03, 3ZPQ, 4GPO, 5KW2, 2Y01, 4PHU, 4AMI, 2YCY, 5TZY, 3ZPR, 5TZR, 4AMJ, 2YCW, 2YCX, 5A8E, 2VT4, 5F8U, 2YCZ, 2Y04, 4BVN, 2Y00
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L
1 1 18
2Y02, 2Y03, 4AMJ, 2YCW, 2YCX, 5A8E, 3ZPQ, 4GPO, 2Y01, 2VT4, 2Y00, 5F8U, 4AMI, 2YCZ, 2Y04, 2YCY, 4BVN, 3ZPR
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K
1 1 1
4BVN
6
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A
1 1 24
2Y02, 6H7N, 2Y03, 6H7L, 3ZPQ, 4GPO, 2Y01, 4AMI, 6H7O, 2YCY, 3ZPR, 6H7J, 6H7M, 4AMJ, 2YCW, 2YCX, 5A8E, 2VT4, 5F8U, 6IBL, 2YCZ, 2Y04, 4BVN, 2Y00
Inactive
Active
A (Rhodopsin)
Peptide
Aminergic
Adrenoceptors
Endothelin
EDNRB
ADRB1
ETB
β1
TM7 7x48
I
F
M
A
2 2 26
2Y02, 6H7N, 2Y03, 6H7L, 3ZPQ, 4GPO, 2Y01, 5XPR, 4AMI, 6H7O, 5X93, 2YCY, 3ZPR, 6H7J, 6H7M, 4AMJ, 2YCW, 2YCX, 5A8E, 2VT4, 5F8U, 6IBL, 2YCZ, 2Y04, 4BVN, 2Y00
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L
1 1 2
5A8E, 4BVN
Pos Match Pos Match 3
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C
1 1 2
4QKX, 3PDS
10
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K
1 1 1
5VBL
Pos Match 26
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y
1 1 4
4MBS, 6AKX, 6AKY, 5UIW
2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N
1 1 4
4MBS, 6AKX, 6AKY, 5UIW
8
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D
1 1 4
4MBS, 6AKX, 6AKY, 5UIW
2 1 6
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E
1 1 4
4MBS, 6AKX, 6AKY, 5UIW
3 1 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A
1 1 1
5LWE
4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A
1 1 1
5LWE
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A
1 1 1
5LWE
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C
1 1 1
5LWE
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A
1 1 1
5LWE
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CXCR4
CXCR4
CCR9
TM6 6x36
T
V
A
P
2 1 4
3OE0, 3OE9, 5LWE, 4RWS
2 1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A
1 1 1
5LWE
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A
1 1 1
5LWE
6
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A
1 1 4
5XR8, 5XRA, 5TGZ, 5U09
1
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
Lysophospholipid (LPA)
LPAR1
CNR1
LPA1
CB1
TM5 5x37
D
E
C
K
2 2 4
5XR8, 5XRA, 4Z36, 5TGZ
1
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E
1 1 3
5XR8, 5XRA, 5TGZ
1 5
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A
1 1 2
4Z9G, 4K5Y
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A
1 1 2
4Z9G, 4K5Y
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A
1 1 2
4Z9G, 4K5Y
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLP1R
GLP-1
CRF1
ECL2 45x52
T
F
A
2 2 3
5NX2, 4Z9G, 4K5Y
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A
1 1 2
4Z9G, 4K5Y
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C
1 1 1
4RWS
14
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y
1 1 2
5X93, 5XPR
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A
1 1 1
5X93
1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A
1 1 2
5X93, 5XPR
2
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A
1 1 2
5X93, 5XPR
4
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A
1 1 4
4PHU, 5KW2, 5TZY, 5TZR
2 1 1
Intermediate
A (Rhodopsin)
Lipid
Peptide
Proteinase-activated
Free fatty acid
PAR2
FFAR1
FFA1
PAR2
TM3 3x34
G
F
A
2 2 5
5NJ6, 5TZR, 5NDZ, 5NDD, 4PHU
1
Intermediate
A (Rhodopsin)
Lipid
Peptide
Free fatty acid
Neurotensin
NTR1
FFAR1
FFA1
NTS1
TM3 3x49
G
E
A
2 2 6
5TZR, 4GRV, 5TZY, 4XES, 4PHU, 5KW2
Pos Match 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM2 2x56
S
C
A
2 1 3
5VEW, 5EE7, 5VEX
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM2 2x59
I
V
F
2 1 3
5VEW, 5EE7, 5VEX
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
ECL1
G
D
Q
T
L
F
A
R
E
2 1 2
5NX2, 5EE7
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM3 3x24
G
S
A
2 1 3
5VEW, 5EE7, 5VEX
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C
1 1 2
5VEW, 5VEX
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A
1 1 2
5VEW, 5VEX
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C
1 1 2
5VEW, 5VEX
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I
1 1 2
5VEW, 5VEX
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLP1R
GLR
glucagon
GLP-1
CRF1
TM6 6x30
Y
K
A
3 2 5
5VEW, 4K5Y, 5VEX, 4Z9G, 5EE7
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F
1 1 2
5VEW, 5VEX
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A
1 1 1
5NX2
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C
A
1 1 3
5NX2, 5VEW, 5VEX
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V
1 1 1
5NX2
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A
1 1 1
5NX2
2 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A
1 1 1
5EE7
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A
1 1 2
5EE7, 5YQZ
2
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLR
glucagon
CRF1
TM2 2x48
A
S
L
A
2 2 3
4Z9G, 5EE7, 4K5Y
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A
1 1 1
5EE7
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F
1 1 1
5EE7
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A
1 1 1
5EE7
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A
1 1 5
5CGC, 6FFI, 4OO9, 6FFH, 5CGD
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y
1 1 5
5CGC, 6FFI, 4OO9, 6FFH, 5CGD
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A
1 1 5
5CGC, 6FFI, 4OO9, 6FFH, 5CGD
Pos Match
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M
1 1 5
5CGC, 6FFI, 4OO9, 6FFH, 5CGD
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A
1 1 5
5CGC, 6FFI, 4OO9, 6FFH, 5CGD
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A
1 1 5
5CGC, 6FFI, 4OO9, 6FFH, 5CGD
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C
1 1 1
4Z36
4
Inactive
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L
1 1 8
4XEE, 4GRV, 4BUO, 4BV0, 4XES, 4BWB, 5T04, 3ZEV
Inactive
Active
Intermediate
A (Rhodopsin)
Lipid
Peptide
Sensory
Opsins
Leukotriene
Neurotensin
Q9WTK1
NTR1
OPSD
OPSD
Rhodopsin
BLT1
NTS1
ECL2
G
D
N
S
C
A
4 3 17
4XEE, 4GRV, 2X72, 3C9M, 5DYS, 5T04, 4ZWJ, 5W0P, 4BEZ, 4XES, 5DGY, 4A4M, 6CMO, 4BEY, 5X33, 2J4Y, 5EN0
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A
1 1 4
4BV0, 4BWB, 4BUO, 3ZEV
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Peptide
Aminergic
Dopamine
Neurotensin
Adenosine
DRD2
NTR1
AA1R
AA2AR
A2A
A1
D2
NTS1
TM6 6x37
L
A
4 3 26
5IUA, 5N2R, 5OLG, 5OM1, 5NLX, 5N2S, 5OLH, 5IUB, 3UZA, 5MZP, 5IU7, 5OLV, 5IU8, 3UZC, 5OM4, 4GRV, 5NM2, 5IU4, 3REY, 3RFM, 3PWH, 5OLO, 5MZJ, 6CM4, 5OLZ, 5NM4
1 1 4
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A
1 1 4
4XES, 4XEE, 4GRV, 5T04
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I
1 1 2
5DYS, 5EN0
19
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q
2 1 5
4ZWJ, 5W0P, 2X72, 5DGY, 6CMO
9
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y
2 1 5
4ZWJ, 5W0P, 4A4M, 5DGY, 6CMO
1 1
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2RY1
P2Y12
P2Y12
P2Y1
TM7 7x49
D
N
2 1 5
4XNW, 4NTJ, 4XNV, 4PY0, 4PXZ
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A
1 1 3
5NDD, 5NJ6, 5NDZ
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A
1 1 3
5NDD, 5NJ6, 5NDZ
1 1 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L
1 1 3
5NDD, 5NJ6, 5NDZ
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A
1 1 3
5NDD, 5NJ6, 5NDZ
1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E
1 1 3
5NDD, 5NJ6, 5NDZ
5
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A
1 1 3
5NDD, 5NJ6, 5NDZ
1 3
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A
1 1 3
5NDD, 5NJ6, 5NDZ
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A
1 1 3
5NDD, 5NJ6, 5NDZ
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F
1 1 2
5L7I, 5L7D
1
Inactive
Active
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N
1 1 2
6BQG, 6BQH
Pos Match 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM5 5x63
L
Y
A
2 1 24
5IUA, 5N2R, 5OLG, 5OM1, 5NLX, 5N2S, 5OLH, 5IUB, 3UZA, 5MZP, 5IU7, 5OLV, 5IU8, 3UZC, 5OM4, 5NM2, 5IU4, 3REY, 3RFM, 3PWH, 5OLO, 5MZJ, 5OLZ, 5NM4
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Dopamine
Adenosine
DRD2
AA1R
AA2AR
A2A
A1
D2
TM6 6x41
V
L
A
3 2 25
5IUA, 5N2R, 5OLG, 5OM1, 5NLX, 5N2S, 5OLH, 5IUB, 3UZA, 5MZP, 5IU7, 5OLV, 5IU8, 3UZC, 5OM4, 5NM2, 5IU4, 3REY, 3RFM, 3PWH, 5OLO, 5MZJ, 6CM4, 5OLZ, 5NM4
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM7 7x41
T
S
A
2 1 24
5IUA, 5N2R, 5OLG, 5OM1, 5NLX, 5N2S, 5OLH, 5IUB, 3UZA, 5MZP, 5IU7, 5OLV, 5IU8, 3UZC, 5OM4, 5NM2, 5IU4, 3REY, 3RFM, 3PWH, 5OLO, 5MZJ, 5OLZ, 5NM4
7
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM2 2x52
A
L
2 1 28
5IUA, 5N2R, 5OLG, 5OM1, 2YDV, 5NLX, 5N2S, 5OLH, 2YDO, 5IUB, 3UZA, 4UHR, 5MZP, 5IU7, 5OLV, 5IU8, 3UZC, 5OM4, 5NM2, 5IU4, 3REY, 4UG2, 3RFM, 3PWH, 5OLO, 5MZJ, 5OLZ, 5NM4
1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N
1 1 1
5WF5
Pos Match 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G
1 1 1
5X33
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G
1 1 1
5X33
1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A
1 1 1
5X33
1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A
1 1 2
4Z9G, 4K5Y
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A
1 1 2
4Z9G, 4K5Y
1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A
1 1 2
4Z9G, 4K5Y
1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A
1 1 2
4Z9G, 4K5Y
Pos Match 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A
1 1 4
4UG2, 4UHR, 2YDV, 2YDO
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A
1 1 4
4UG2, 4UHR, 2YDV, 2YDO
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A
1 1 4
4UG2, 4UHR, 2YDV, 2YDO
11
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A
1 1 23
5IUA, 5N2R, 5OLG, 5OM1, 5NLX, 5OLH, 5IUB, 3UZA, 5MZP, 5IU7, 5OLV, 5IU8, 3UZC, 5OM4, 5NM2, 5IU4, 3REY, 3RFM, 3PWH, 5OLO, 5MZJ, 5OLZ, 5NM4
1 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A
1 1 23
5IUA, 5N2R, 5OLG, 5OM1, 5NLX, 5OLH, 5IUB, 3UZA, 5MZP, 5IU7, 5OLV, 5IU8, 3UZC, 5OM4, 5NM2, 5IU4, 3REY, 3RFM, 3PWH, 5OLO, 5MZJ, 5OLZ, 5NM4
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A
1 1 1
5WF6
Pos Match 1
STATE TARGETS MUTATIONS FREQUENCY DATA (MUTANT) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM3 3x36
T
A 2 1 24
5IUA, 5N2R, 5OLG, 5OM1, 5NLX, 5N2S, 5OLH, 5NM4, 5IUB, 3UZA, 5MZP, 5IU7, 5OLV, 5IU8, 3UZC, 5NM2, 5IU4, 3REY, 3RFM, 3PWH, 5OLO, 5MZJ, 5OLZ, 5OM4
0.02 0 0.50 23
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S 1 1 24
2Y02, 6H7N, 2Y03, 6H7L, 3ZPQ, 4GPO, 2Y01, 4AMI, 6H7O, 2YCY, 3ZPR, 6H7J, 6H7M, 4AMJ, 2YCW, 2YCX, 5A8E, 2VT4, 5F8U, 6IBL, 2YCZ, 2Y04, 4BVN, 2Y00
0.04 0.50 0.46
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V 1 1 24
2Y02, 6H7N, 2Y03, 6H7L, 3ZPQ, 4GPO, 2Y01, 4AMI, 6H7O, 2YCY, 3ZPR, 6H7J, 6H7M, 4AMJ, 2YCW, 2YCX, 5A8E, 2VT4, 5F8U, 6IBL, 2YCZ, 2Y04, 4BVN, 2Y00
0.23 0.33 0.61 -0.46 2
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM3 3x40
I
V 1 1 2
5A8E, 4BVN
0.24 0.61 -0.46 2
Inactive
Active
Intermediate
A (Rhodopsin)
Aminergic
Protein
5-Hydroxytryptamine
Adrenoceptors
Dopamine
Chemokine
ADRB2
ADRB1
DRD3
CXCR4
5HT1B
5HT2B
CXCR4
β2
5-HT1B
5-HT2B
D3
β1
TM3 3x41
M
L
E
W 6 4 24
3NYA, 6G79, 3OE6, 4RWS, 5TUD, 3ODU, 3OE0, 3OE9, 4IB4, 6DS0, 6DRY, 5TVN, 5A8E, 6DRZ, 3D4S, 4IAR, 5V54, 6DRX, 4IAQ, 3NY9, 3NY8, 3OE8, 4NC3, 3PBL
0.03 0.49 -2.09 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM5 5x58
Y
A 1 1 18
2Y02, 2Y03, 4AMJ, 2YCW, 2YCX, 5A8E, 3ZPQ, 4GPO, 2Y01, 2VT4, 2Y00, 5F8U, 4AMI, 2YCZ, 2Y04, 2YCY, 4BVN, 3ZPR
0.03 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L 1 1 18
2Y02, 2Y03, 4AMJ, 2YCW, 2YCX, 5A8E, 3ZPQ, 4GPO, 2Y01, 2VT4, 2Y00, 5F8U, 4AMI, 2YCZ, 2Y04, 2YCY, 4BVN, 3ZPR
0.11 0.11 0.21 -1.25
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K 1 1 1
4BVN
0.04 0.11 0.26 2.80 6
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A 1 1 24
2Y02, 6H7N, 2Y03, 6H7L, 3ZPQ, 4GPO, 2Y01, 4AMI, 6H7O, 2YCY, 3ZPR, 6H7J, 6H7M, 4AMJ, 2YCW, 2YCX, 5A8E, 2VT4, 5F8U, 6IBL, 2YCZ, 2Y04, 4BVN, 2Y00
0.1 0.11 0 0.50
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48
F
M 1 1 24
2Y02, 6H7N, 2Y03, 6H7L, 3ZPQ, 4GPO, 2Y01, 4AMI, 6H7O, 2YCY, 3ZPR, 6H7J, 6H7M, 4AMJ, 2YCW, 2YCX, 5A8E, 2VT4, 5F8U, 6IBL, 2YCZ, 2Y04, 4BVN, 2Y00
0.05 0.24 -0.67
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L 1 1 2
5A8E, 4BVN
0.03 0.21 -1.25 Pos Match (But Not Mutant AA) Pos & Mutant AA Match 3
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C 1 1 2
4QKX, 3PDS
0.0 0.68 -0.02 10
Inactive
A (Rhodopsin)
Peptide
Aminergic
Dopamine
Apelin
DRD2
APJ
D2
apelin
TM3 3x40
I
V
A 2 2 2
6CM4, 5VBL
0.06 0 0.50 2
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K 1 1 1
5VBL
0.26 2.80 Pos Match (But Not Mutant AA) 26
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y 1 1 4
4MBS, 6AKX, 6AKY, 5UIW
0.07 0.53 -0.71 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N 1 1 4
4MBS, 6AKX, 6AKY, 5UIW
0.03 0.65 0.85 8
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D 1 1 4
4MBS, 6AKX, 6AKY, 5UIW
0.69 0.43 2 1 6
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E 1 1 4
4MBS, 6AKX, 6AKY, 5UIW
0.12 0.40 0.11 3 1 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A 1 1 1
5LWE
0.04 0 0.50 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A 1 1 1
5LWE
0.07 0 0.50 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A 1 1 1
5LWE
0.12 0 0.50 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C 1 1 1
5LWE
0.02 0.68 -0.02
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A 1 1 1
5LWE
0.07 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36
V
A 1 1 1
5LWE
0.02 0 0.50 2 1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A 1 1 1
5LWE
0.14 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A 1 1 1
5LWE
0.08 0 0.50 6
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A 1 1 4
5XR8, 5XRA, 5TGZ, 5U09
0.01 0 0.50 1
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37
E
K 1 1 3
5XR8, 5XRA, 5TGZ
0.11 0.26 2.80 1
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E 1 1 3
5XR8, 5XRA, 5TGZ
0.04 0.40 0.11 1 5
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLP1R
GLP-1
CRF1
ECL2 45x52
T
F
A 2 2 3
5NX2, 4Z9G, 4K5Y
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C 1 1 1
4RWS
0.68 -0.02 14
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36
T
P 1 1 3
3OE0, 3OE9, 4RWS
0.0 3.16 0.14 2 1 5
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y 1 1 2
5X93, 5XPR
0.09 0.53 -0.71
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A 1 1 1
5X93
0.08 0 0.50 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A 1 1 2
5X93, 5XPR
0.07 0 0.50 2
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A 1 1 2
5X93, 5XPR
0.1 0 0.50 4
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48
I
A 1 1 2
5X93, 5XPR
0.13 0 0.50
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A 1 1 4
4PHU, 5KW2, 5TZY, 5TZR
0.06 0 0.50 2 1 1
Intermediate
A (Rhodopsin)
Lipid
Peptide
Proteinase-activated
Free fatty acid
PAR2
FFAR1
FFA1
PAR2
TM3 3x34
G
F
A 2 2 5
5NJ6, 5TZR, 5NDZ, 5NDD, 4PHU
0.07 0 0.50 1
Intermediate
A (Rhodopsin)
Lipid
Peptide
Free fatty acid
Neurotensin
NTR1
FFAR1
FFA1
NTS1
TM3 3x49
G
E
A 2 2 6
5TZR, 4GRV, 5TZY, 4XES, 4PHU, 5KW2
0.01 0 0.50 Pos & Mutant AA Match 2
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM5 5x58
Y
F 1 1 4
4PHU, 5KW2, 5TZY, 5TZR
0.01 0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x56
S
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM2 2x59
I
V
F 2 1 3
5VEW, 5EE7, 5VEX
0.54 -1.71
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
ECL1
G
T
E 2 1 2
5NX2, 5EE7
0.40 0.11
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
G
Q
A 1 1 1
5NX2
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
D
R 1 1 1
5NX2
0.21 1.81
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM3 3x24
G
S
A 2 1 3
5VEW, 5EE7, 5VEX
0.07 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F 1 1 1
5NX2
0.4 0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2
L
F 1 1 1
5NX2
0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A 1 1 2
5VEW, 5VEX
0.07 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C 1 1 2
5VEW, 5VEX
0.68 -0.02 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I 1 1 2
5VEW, 5VEX
0.07 0.41 -1.12
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
Corticotropin-releasing factor
CRFR1
GLP1R
GLR
glucagon
GLP-1
CRF1
TM6 6x30
Y
K
A 3 2 5
5VEW, 4K5Y, 5VEX, 4Z9G, 5EE7
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F 1 1 2
5VEW, 5VEX
0.07 0.54 -1.71 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A 1 1 1
5NX2
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V 1 1 1
5NX2
0.61 -0.46 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A 1 1 1
5NX2
0.07 0 0.50 2 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A 1 1 1
5EE7
0.33 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A 1 1 2
5EE7, 5YQZ
0 0.50 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48
A
L 1 1 1
5EE7
0.2 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x56
S
A 1 1 1
5EE7
0.27 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A 1 1 1
5EE7
0.27 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F 1 1 1
5EE7
0.13 0.54 -1.71 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A 1 1 1
5EE7
0.07 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A 1 1 5
5CGC, 6FFI, 4OO9, 6FFH, 5CGD
0.05 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y 1 1 5
5CGC, 6FFI, 4OO9, 6FFH, 5CGD
0.05 0.53 -0.71
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A 1 1 5
5CGC, 6FFI, 4OO9, 6FFH, 5CGD
0 0.50 Pos & Mutant AA Match
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M 1 1 5
5CGC, 6FFI, 4OO9, 6FFH, 5CGD
0.24 -0.67
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A 1 1 5
5CGC, 6FFI, 4OO9, 6FFH, 5CGD
0.05 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A 1 1 5
5CGC, 6FFI, 4OO9, 6FFH, 5CGD
0 0.50
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37
D
C 1 1 1
4Z36
0.68 -0.02 1
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C 1 1 1
4Z36
0.01 0.68 -0.02 4
Inactive
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L 1 1 8
4XEE, 4GRV, 4BUO, 4BV0, 4XES, 4BWB, 5T04, 3ZEV
0.37 0.21 -1.25
Inactive
Active
Intermediate
A (Rhodopsin)
Lipid
Peptide
Leukotriene
Neurotensin
Q9WTK1
NTR1
BLT1
NTS1
ECL2
G
S
A 2 2 5
4XEE, 4GRV, 4XES, 5X33, 5T04
0 0.50
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A 1 1 4
4BV0, 4BWB, 4BUO, 3ZEV
0.02 0 0.50
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Peptide
Aminergic
Dopamine
Neurotensin
Adenosine
DRD2
NTR1
AA1R
AA2AR
A2A
A1
D2
NTS1
TM6 6x37
L
A 4 3 26
5IUA, 5N2R, 5OLG, 5OM1, 5NLX, 5N2S, 5OLH, 5IUB, 3UZA, 5MZP, 5IU7, 5OLV, 5IU8, 3UZC, 5OM4, 4GRV, 5NM2, 5IU4, 3REY, 3RFM, 3PWH, 5OLO, 5MZJ, 6CM4, 5OLZ, 5NM4
0.04 0 0.50 1 1 4
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A 1 1 4
4XES, 4XEE, 4GRV, 5T04
0.19 0 0.50
Inactive
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term
D
N
C 2 1 12
2X72, 3C9M, 5DYS, 4ZWJ, 6CMO, 5W0P, 4BEZ, 5DGY, 4A4M, 4BEY, 2J4Y, 5EN0
0.68 -0.02
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I 1 1 2
5DYS, 5EN0
0.04 0.29 0.41 -1.12 19
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q 2 1 5
4ZWJ, 5W0P, 2X72, 5DGY, 6CMO
0.01 0.39 0.77 9
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y 2 1 5
4ZWJ, 5W0P, 4A4M, 5DGY, 6CMO
0.01 0.53 -0.71 1 1
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2RY1
P2Y12
P2Y12
P2Y1
TM7 7x49
D
N 2 1 5
4XNW, 4NTJ, 4XNV, 4PY0, 4PXZ
0.72 0.65 0.85
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.11 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.05 0 0.50 1 1 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L 1 1 3
5NDD, 5NJ6, 5NDZ
0.73 0.21 -1.25
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.0 0 0.50 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E 1 1 3
5NDD, 5NJ6, 5NDZ
0.01 0.40 0.11 5
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.13 0 0.50 1 3
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.14 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.13 0 0.50
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F 1 1 2
5L7I, 5L7D
0.54 -1.71 1
Inactive
Active
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N 1 1 2
6BQG, 6BQH
0.67 0.65 0.85 Pos & AA Mutant Match 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM5 5x63
L
Y
A 2 1 24
5IUA, 5N2R, 5OLG, 5OM1, 5NLX, 5N2S, 5OLH, 5IUB, 3UZA, 5MZP, 5IU7, 5OLV, 5IU8, 3UZC, 5OM4, 5NM2, 5IU4, 3REY, 3RFM, 3PWH, 5OLO, 5MZJ, 5OLZ, 5NM4
0.06 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Dopamine
Adenosine
DRD2
AA1R
AA2AR
A2A
A1
D2
TM6 6x41
V
L
A 3 2 25
5IUA, 5N2R, 5OLG, 5OM1, 5NLX, 5N2S, 5OLH, 5IUB, 3UZA, 5MZP, 5IU7, 5OLV, 5IU8, 3UZC, 5OM4, 5NM2, 5IU4, 3REY, 3RFM, 3PWH, 5OLO, 5MZJ, 6CM4, 5OLZ, 5NM4
0.05 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM7 7x41
T
S
A 2 1 24
5IUA, 5N2R, 5OLG, 5OM1, 5NLX, 5N2S, 5OLH, 5IUB, 3UZA, 5MZP, 5IU7, 5OLV, 5IU8, 3UZC, 5OM4, 5NM2, 5IU4, 3REY, 3RFM, 3PWH, 5OLO, 5MZJ, 5OLZ, 5NM4
0.38 0 0.50 7
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM2 2x52
A
L 2 1 28
5IUA, 5N2R, 5OLG, 5OM1, 2YDV, 5NLX, 5N2S, 5OLH, 2YDO, 5IUB, 3UZA, 4UHR, 5MZP, 5IU7, 5OLV, 5IU8, 3UZC, 5OM4, 5NM2, 5IU4, 3REY, 4UG2, 3RFM, 3PWH, 5OLO, 5MZJ, 5OLZ, 5NM4
0.63 0.21 -1.25 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N 1 1 1
5WF5
0.03 0.65 0.85 Pos & AA Mutant Match 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G 1 1 1
5X33
0.25 1.00 1.15
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G 1 1 1
5X33
0.67 1.00 1.15 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A 1 1 1
5X33
0.08 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A 1 1 2
4Z9G, 4K5Y
0.07 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48
S
A 1 1 2
4Z9G, 4K5Y
0.2 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A 1 1 2
4Z9G, 4K5Y
0 0.50 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A 1 1 2
4Z9G, 4K5Y
0 0.50 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A 1 1 2
4Z9G, 4K5Y
0 0.50 Pos & Mutant AA Match 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A 1 1 4
4UG2, 4UHR, 2YDV, 2YDO
0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A 1 1 4
4UG2, 4UHR, 2YDV, 2YDO
0.13 0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A 1 1 4
4UG2, 4UHR, 2YDV, 2YDO
0.03 0 0.50 11
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A 1 1 23
5IUA, 5N2R, 5OLG, 5OM1, 5NLX, 5OLH, 5IUB, 3UZA, 5MZP, 5IU7, 5OLV, 5IU8, 3UZC, 5OM4, 5NM2, 5IU4, 3REY, 3RFM, 3PWH, 5OLO, 5MZJ, 5OLZ, 5NM4
0.08 0 0.50 1 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A 1 1 23
5IUA, 5N2R, 5OLG, 5OM1, 5NLX, 5OLH, 5IUB, 3UZA, 5MZP, 5IU7, 5OLV, 5IU8, 3UZC, 5OM4, 5NM2, 5IU4, 3REY, 3RFM, 3PWH, 5OLO, 5MZJ, 5OLZ, 5NM4
0.13 0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A 1 1 1
5WF6
0.03 0 0.50 Pos & AA Mutant Match 1
STATE TARGETS MUTATIONS FREQUENCY DATA (WILD TYPE) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A2A
A1
TM3 3x36 T
A
2 1 24
5IUA, 5N2R, 5OLG, 5OM1, 5NLX, 5N2S, 5OLH, 5NM4, 5IUB, 3UZA, 5MZP, 5IU7, 5OLV, 5IU8, 3UZC, 5NM2, 5IU4, 3REY, 3RFM, 3PWH, 5OLO, 5MZJ, 5OLZ, 5OM4
0.05 0.66 0.25 23
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59 R
S
1 1 24
2Y02, 6H7N, 2Y03, 6H7L, 3ZPQ, 4GPO, 2Y01, 4AMI, 6H7O, 2YCY, 3ZPR, 6H7J, 6H7M, 4AMJ, 2YCW, 2YCX, 5A8E, 2VT4, 5F8U, 6IBL, 2YCZ, 2Y04, 4BVN, 2Y00
0.23 0.21 1.81
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53 M
V
1 1 24
2Y02, 6H7N, 2Y03, 6H7L, 3ZPQ, 4GPO, 2Y01, 4AMI, 6H7O, 2YCY, 3ZPR, 6H7J, 6H7M, 4AMJ, 2YCW, 2YCX, 5A8E, 2VT4, 5F8U, 6IBL, 2YCZ, 2Y04, 4BVN, 2Y00
0.07 0.33 0.24 -0.67 2
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
Dopamine
DRD2
ADRB1
D2
β1
TM3 3x40 I
V
A
2 2 3
5A8E, 6CM4, 4BVN
0.4 0.41 -1.12 2
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
ADRB1
β1
β2
TM3 3x41 E
W
2 1 5
3NYA, 3NY9, 3NY8, 5A8E, 3D4S
0.01 0.33 0.40 0.11 1
Inactive
Intermediate
A (Rhodopsin)
Lipid
Aminergic
Adrenoceptors
Free fatty acid
ADRB1
FFAR1
FFA1
β1
TM5 5x58 Y
F
A
2 2 22
2Y02, 2Y03, 3ZPQ, 4GPO, 5KW2, 2Y01, 4PHU, 4AMI, 2YCY, 5TZY, 3ZPR, 5TZR, 4AMJ, 2YCW, 2YCX, 5A8E, 2VT4, 5F8U, 2YCZ, 2Y04, 4BVN, 2Y00
0.71 0.53 -0.71
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27 A
L
1 1 18
2Y02, 2Y03, 4AMJ, 2YCW, 2YCX, 5A8E, 3ZPQ, 4GPO, 2Y01, 2VT4, 2Y00, 5F8U, 4AMI, 2YCZ, 2Y04, 2YCY, 4BVN, 3ZPR
0.08 0.11 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31 D
K
1 1 1
4BVN
0.1 0.22 0.69 0.43 6
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36 F
A
1 1 24
2Y02, 6H7N, 2Y03, 6H7L, 3ZPQ, 4GPO, 2Y01, 4AMI, 6H7O, 2YCY, 3ZPR, 6H7J, 6H7M, 4AMJ, 2YCW, 2YCX, 5A8E, 2VT4, 5F8U, 6IBL, 2YCZ, 2Y04, 4BVN, 2Y00
0.14 0.44 0.54 -1.71
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48 F
M
1 1 24
2Y02, 6H7N, 2Y03, 6H7L, 3ZPQ, 4GPO, 2Y01, 4AMI, 6H7O, 2YCY, 3ZPR, 6H7J, 6H7M, 4AMJ, 2YCW, 2YCX, 5A8E, 2VT4, 5F8U, 6IBL, 2YCZ, 2Y04, 4BVN, 2Y00
0.06 0.33 0.54 -1.71
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53 Y
L
1 1 2
5A8E, 4BVN
0.89 1.0 0.53 -0.71 Pos & Wild Type AA Match Pos & Wild Type AA Match 3
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63 H
C
1 1 2
4QKX, 3PDS
0.03 0.11 0.61 0.11 10
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM3 3x40 V
A
1 1 1
5VBL
0.24 0.61 -0.46 2
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48 W
K
1 1 1
5VBL
0.68 0.49 -2.09 Pos & Wild Type AA Match 26
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60 C
Y
1 1 4
4MBS, 6AKX, 6AKY, 5UIW
0.02 0.68 -0.02 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61 G
N
1 1 4
4MBS, 6AKX, 6AKY, 5UIW
0.02 1.00 1.15 8
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33 A
D
1 1 4
4MBS, 6AKX, 6AKY, 5UIW
0.29 0 0.50 2 1 6
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49 K
E
1 1 4
4MBS, 6AKX, 6AKY, 5UIW
0.13 0.26 2.80 3 1 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48 T
A
1 1 1
5LWE
0.05 0.66 0.25 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50 V
A
1 1 1
5LWE
0.03 0.61 -0.46 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38 M
A
1 1 1
5LWE
0.04 0.24 -0.67 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47 S
C
1 1 1
5LWE
0.56 0.50 0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41 T
A
1 1 1
5LWE
0.09 0.66 0.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36 V
A
1 1 1
5LWE
0.15 0.61 -0.46 2 1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29 N
A
1 1 1
5LWE
0.04 0.65 0.85
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39 T
A
1 1 1
5LWE
0.03 0.66 0.25 6
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46 T
A
1 1 4
5XR8, 5XRA, 5TGZ, 5U09
0.01 0.66 0.25 1
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37 E
K
1 1 3
5XR8, 5XRA, 5TGZ
0.03 0.40 0.11 1
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32 R
E
1 1 3
5XR8, 5XRA, 5TGZ
0.31 0.21 1.81 1 5
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36 V
A
1 1 2
4Z9G, 4K5Y
0.07 0.61 -0.46
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60 L
A
1 1 2
4Z9G, 4K5Y
0.33 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43 K
A
1 1 2
4Z9G, 4K5Y
0.13 0.26 2.80
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
ECL2 45x52 F
A
1 1 2
4Z9G, 4K5Y
0.13 0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48 I
A
1 1 2
4Z9G, 4K5Y
0.2 0.41 -1.12
Inactive
Active
Intermediate
A (Rhodopsin)
Aminergic
Protein
Dopamine
Chemokine
5-Hydroxytryptamine
5HT1B
DRD3
CXCR4
CXCR4
5-HT1B
D3
TM3 3x41 L
W
3 3 11
3OE8, 6G79, 3OE6, 4IAR, 5V54, 4IAQ, 4RWS, 3ODU, 3OE0, 3OE9, 3PBL
0.31 0.21 -1.25 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51 D
C
1 1 1
4RWS
0.03 0.69 0.43 14
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36 T
P
1 1 3
3OE0, 3OE9, 4RWS
0.25 0.66 0.25 2 1 5
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55 R
Y
1 1 2
5X93, 5XPR
0.02 0.21 1.81
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56 D
A
1 1 1
5X93
0.01 0.69 0.43 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36 K
A
1 1 2
5X93, 5XPR
0.06 0.26 2.80 2
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54 S
A
1 1 2
5X93, 5XPR
0.05 0.50 0.46 4
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48 I
A
1 1 2
5X93, 5XPR
0.15 0.41 -1.12
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40 L
A
1 1 4
4PHU, 5KW2, 5TZY, 5TZR
0.03 0.21 -1.25 2 1 1
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x34 F
A
1 1 2
4PHU, 5TZR
0.11 0.54 -1.71 1
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x49 G
A
1 1 4
4PHU, 5KW2, 5TZY, 5TZR
0.01 1.00 1.15 Pos & Wild Type AA Match 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM2 2x56 S
C
A
2 1 3
5VEW, 5EE7, 5VEX
0.47 0.50 0.46
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x59 I
F
1 1 2
5VEW, 5VEX
0.4 0.41 -1.12
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 T
E
1 1 1
5NX2
0.66 0.25
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 Q
A
1 1 1
5NX2
0.39 0.77
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 D
R
1 1 1
5NX2
0.69 0.43
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x24 S
A
1 1 2
5VEW, 5VEX
0.27 0.50 0.46
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31 L
F
1 1 1
5NX2
0.2 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32 M
C
1 1 2
5VEW, 5VEX
0.13 0.24 -0.67
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2 L
F
1 1 1
5NX2
0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48 S
A
1 1 2
5VEW, 5VEX
0.07 0.50 0.46
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
ECL2 G
A
E
2 1 2
5NX2, 5EE7
1.00 1.15
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL2 45x52 T
A
1 1 1
5NX2
0.2 0.66 0.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51 I
C
1 1 2
5VEW, 5VEX
0.6 0.41 -1.12 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52 G
I
1 1 2
5VEW, 5VEX
0.2 1.00 1.15
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63 C
A
1 1 1
5NX2
0.07 0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
glucagon
GLP-1
TM6 6x30 K
A
2 1 3
5VEW, 5EE7, 5VEX
0.2 0.26 2.80
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31 C
F
1 1 2
5VEW, 5VEX
0.07 0.68 -0.02 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42 P
A
1 1 1
5NX2
0.93 3.16 0.14
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45 G
C
A
1 1 3
5NX2, 5VEW, 5VEX
1.0 1.00 1.15
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47 H
V
1 1 1
5NX2
0.73 0.61 0.11 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56 V
A
1 1 1
5NX2
0.07 0.61 -0.46 2 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48 G
A
1 1 1
5EE7
0.13 1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39 R
A
1 1 2
5EE7, 5YQZ
1.0 0.21 1.81 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48 A
L
1 1 1
5EE7
0.2 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x59 V
F
1 1 1
5EE7
0.4 0.61 -0.46
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM3 3x24 G
A
1 1 1
5EE7
0.4 1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54 M
A
1 1 1
5EE7
0.07 0.24 -0.67
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48 E
F
1 1 1
5EE7
0.27 0.40 0.11 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39 F
A
1 1 1
5EE7
0.33 0.54 -1.71
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35 E
A
1 1 5
5CGC, 6FFI, 4OO9, 6FFH, 5CGD
0.09 0.40 0.11
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48 N
Y
1 1 5
5CGC, 6FFI, 4OO9, 6FFH, 5CGD
0.41 0.65 0.85
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50 I
A
1 1 5
5CGC, 6FFI, 4OO9, 6FFH, 5CGD
0.5 0.41 -1.12 Pos & Wild Type AA Match
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2 G
M
1 1 5
5CGC, 6FFI, 4OO9, 6FFH, 5CGD
1.00 1.15
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42 T
A
1 1 5
5CGC, 6FFI, 4OO9, 6FFH, 5CGD
0.09 0.66 0.25
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53 S
A
1 1 5
5CGC, 6FFI, 4OO9, 6FFH, 5CGD
0.14 0.50 0.46
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37 D
C
1 1 1
4Z36
0.01 0.69 0.43 1
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59 V
C
1 1 1
4Z36
0.12 0.61 -0.46 4
Inactive
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54 A
L
1 1 8
4XEE, 4GRV, 4BUO, 4BV0, 4XES, 4BWB, 5T04, 3ZEV
0.04 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM3 3x49 E
A
1 1 2
4XES, 4GRV
0.21 0.40 0.11 Pos & Wild Type AA Match 2
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
ECL2 G
A
1 1 4
4XES, 4XEE, 4GRV, 5T04
1.00 1.15
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54 I
A
1 1 4
4BV0, 4BWB, 4BUO, 3ZEV
0.33 0.41 -1.12
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Peptide
Aminergic
Dopamine
Neurotensin
Adenosine
DRD2
NTR1
AA1R
AA2AR
A2A
A1
D2
NTS1
TM6 6x37 L
A
4 3 26
5IUA, 5N2R, 5OLG, 5OM1, 5NLX, 5N2S, 5OLH, 5IUB, 3UZA, 5MZP, 5IU7, 5OLV, 5IU8, 3UZC, 5OM4, 4GRV, 5NM2, 5IU4, 3REY, 3RFM, 3PWH, 5OLO, 5MZJ, 6CM4, 5OLZ, 5NM4
0.38 0.21 -1.25 1 1 4
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43 V
A
1 1 4
4XES, 4XEE, 4GRV, 5T04
0.1 0.61 -0.46
Inactive
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term N
C
2 1 12
2X72, 3C9M, 5DYS, 4ZWJ, 6CMO, 5W0P, 4BEZ, 5DGY, 4A4M, 4BEY, 2J4Y, 5EN0
0.65 0.85
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60 T
I
1 1 2
5DYS, 5EN0
0.08 0.43 0.66 0.25 19
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28 E
Q
2 1 5
4ZWJ, 5W0P, 2X72, 5DGY, 6CMO
0.02 0.57 0.40 0.11 9
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40 M
Y
2 1 5
4ZWJ, 5W0P, 4A4M, 5DGY, 6CMO
0.05 0.71 0.24 -0.67 1 1
Inactive
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
ECL3 D
C
1 1 8
4BEZ, 3C9M, 4A4M, 2X72, 4BEY, 2J4Y, 5DYS, 5EN0
0.69 0.43
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2RY1
P2Y12
P2Y12
P2Y1
TM