Experiment Browser
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RECEPTOR | EXPRESSION | SOLUBILIZATION | PURIFICATION | STRUCTURE DETERMINATION | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PDB | pH | Temp | Resolution | Reference | Date | ||||||||||||||||||
7PX4 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Preladenant conjugat...
pubchem
|
Antagonist | 2.3 | Inactive | 10.1002/ANIE.202115545 | 2022-03-02 | |
6OS9 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JMV449
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 10.1038/S41586-019-1337-6 | 2019-07-10 | |
5D6L | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C |
Carazolol
pubchem
|
Inverse agonist | 3.2 | Inactive | 10.1038/NPROT.2017.057 | 2016-08-17 | |
7WY0 | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 10.1038/S41467-022-33173-4 | 2022-09-28 | |
6WPW | GLR | glucagon | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Glucagon derivative ...
|
Agonist | 3.1 | Active | 10.1126/SCIENCE.ABA3373 | 2020-08-12 | |
6LPL | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.0 | Inactive | 10.1038/S41598-020-76277-X | 2020-11-25 | |
7X2C | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
fenoldopam
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
gtoplig
chembl_ligand
pubchem
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41467-022-30929-W | 2022-06-29 | |
3NY8 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.5-8.0 | 20°C |
ICI 118551
pubchem
gtoplig
chembl_ligand
chembl_ligand
pubchem
|
Inverse agonist | 2.8 | Inactive | 10.1021/JA105108Q | 2010-08-11 | |
3D4S | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C |
timolol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Inverse agonist | 2.8 | Inactive | 10.1016/J.STR.2008.05.001 | 2008-06-17 | |
7W40 | GRPR | BB2 | Bombesin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Bombesin
|
Agonist | 3.0 | Active | 10.1073/PNAS.2216230120 | 2023-02-22 | |
5NJ6 | PAR2 | PAR2 | Proteinase-activated | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 5.5-6.2 | 20°C | N/A | N/A | 4.0 | Intermediate | 10.1038/NATURE22309 | 2017-05-03 | |
7X2D | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
TAVAPADON
chembl_ligand
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41467-022-30929-W | 2022-06-15 | |
8HJ5 | MRGX1 | MRGPRX1 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 16 [PMID: 3...
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 2023-05-31 | ||
7F1R | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCL5
gtoplig
|
Agonist | 3.0 | Active | 2021-07-14 | ||
8DWC | MRGX1 | MRGPRX1 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Proenkephalin-A
|
Agonist | 2.9 | Active | 10.1038/S41589-022-01173-6 | 2022-11-02 | |
8I2G | FSHR | FSH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Glycoprotein alpha
Follitropin subunit ... FSHR agonist 1 pubchem |
AgonistAgonistAllosteric agonist | 2.8 | Active | 10.1038/S41467-023-36170-3 | 2023-03-29 | |
7PIV | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
afamelanotide
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
pubchem
pubchem
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41422-021-00569-8 | 2021-11-17 | |
3EML | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.5-6.5 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.6 | Inactive | 10.1126/SCIENCE.1164772 | 2008-10-14 | |
6XBK | SMO | SMO | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cholesterol
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41589-020-0646-2 | 2020-09-30 | |
6PWC | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL48981
chembl_ligand
pubchem
|
Agonist | 4.9 | Active | 10.1038/S41422-019-0256-2 | 2019-12-04 | |
7WVX | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
humanin
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-022-29361-X | 2022-04-13 | |
7X9Y | CCR3 | CCR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 10.1038/S41421-022-00403-4 | 2022-08-24 | |
6BQG | 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
ergotamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.0 | Active | 10.1016/j.cell.2018.01.001 | 2018-02-14 | |
5MZJ | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20 |
theophylline
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Antagonist | 2.0 | Inactive | 10.1016/j.str.2017.06.012 | 2017-07-26 | |
6TKO | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
arformoterol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.3 | Active | 10.1038/S41586-020-2419-1 | 2020-06-17 | |
7BVQ | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Carazolol
pubchem
|
Inverse agonist | 2.5 | Inactive | 10.1038/S41422-020-00424-2 | 2020-12-02 | |
7SK6 | ACKR3 | ACKR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Stromal cell-derived...
|
Agonist | 4.0 | Active | 10.1126/SCIADV.ABN8063 | 2022-07-27 | |
7BZ2 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
arformoterol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.8 | Active | 10.1038/S41421-020-0176-9 | 2020-08-05 | |
6NI3 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1615159
chembl_ligand
pubchem
|
Agonist | 3.8 | Active | 10.1038/S41594-019-0330-Y | 2019-11-20 | |
7TYH | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcitonin human
pubchem
|
Agonist | 3.3 | Active | 2022-03-23 | ||
8F7Q | OPRM | μ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
β-endorphin
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | |
7XV3 | GP174 | GPR174 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2~{S})-2-$l^{4}-aza...
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-023-36575-0 | 2023-02-15 | |
7TRP | ACM4 | M4 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
iperoxo
pubchem
gtoplig
chembl_ligand
LY2033298 pubchem gtoplig chembl_ligand |
AgonistPAM | 2.4 | Active | 2023-05-17 | ||
6D26 | PD2R2 | DP2 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
fevipiprant
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.8 | Inactive | 10.1016/J.MOLCEL.2018.08.009 | 2018-10-03 | |
3VW7 | PAR1 | PAR1 | Proteinase-activated | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.5 | 20°C |
vorapaxar
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Antagonist | 2.2 | Intermediate | 10.1038/NATURE11701 | 2012-12-12 | |
5XF1 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C |
NNC0640
pubchem
gtoplig
|
NAM | 3.2 | Inactive | 10.1038/NATURE22363 | 2017-05-24 | |
7WVW | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
FME-TYR-PHE-ILE-ASN-...
|
Agonist | 3.1 | Active | 10.1038/S41467-022-29361-X | 2022-04-13 | |
7VVO | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Parathyroid hormone
|
Agonist | 4.1 | Active | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | |
8FLT | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
M-PTH(1-14)
|
Agonist | 3.0 | Active | 10.1016/J.STR.2023.04.002 | 2023-04-26 | |
8F7S | OPRD | δ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
DELTORPHIN II
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | |
7WQ3 | GALR1 | GAL1 | Galanin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
galanin
gtoplig
chembl_ligand
gtoplig
pubchem
pubchem
pubchem
pubchem
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41467-022-29072-3 | 2022-04-20 | |
5JQH | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | 7.7 MAG | 5 chems | 7.5-7.5 | 23°C |
Carazolol
pubchem
|
Inverse agonist | 3.2 | Inactive | 10.1038/NATURE18636 | 2016-07-13 | |
8GNG | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
istradefylline
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Antagonist | 3.2 | Inactive | 10.1124/MOLPHARM.122.000633 | 2023-03-22 | |
7WC8 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LUMATEPERONE
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 2.5 | Inactive | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | |
7F8Y | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
DEVAZEPIDE
chembl_ligand
pubchem
|
Antagonist | 2.5 | Inactive | 10.1038/S41589-021-00866-8 | 2021-10-13 | |
7VBH | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Peptide 20
|
Agonist | 3.0 | Active | 10.1038/S41467-022-28683-0 | 2022-04-06 | |
6ME8 | MTR1B | MT2 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL15060
chembl_ligand
pubchem
|
Agonist | 3.1 | Inactive | 10.1038/S41586-019-1144-0 | 2019-04-24 | |
6Z66 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Intermediate | 10.1126/sciadv.abe5504 | 2021-02-10 | |
6DS0 | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY266097
pubchem
|
Antagonist | 3.2 | Intermediate | 10.1038/s41594-018-0116-7 | 2018-08-29 | |
7XK8 | NMUR2 | NMU2 | Neuromedin U | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Neuromedin U-25 (hum...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41467-022-34814-4 | 2023-02-22 | |
5TVN | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.5-8.0 | 20°C |
Lysergide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.9 | Intermediate | 10.1016/J.CELL.2016.12.033 | 2017-02-01 | |
6ME9 | MTR1B | MT2 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ramelteon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.3 | Inactive | 10.1038/S41586-019-1144-0 | 2019-04-24 | |
8FMZ | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 2.6 | Active | 10.1021/ACS.BIOCHEM.3C00029 | 2023-03-29 | |
6G79 | 5HT1B | 5-HT1B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | Cryo-EM | Volta phase plate, Falcon III detector (FEI Titan Krios, 300kV) | 5 chems | 7.5-7.5 | 4°C |
donitriptan
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.8 | Active | 10.1038/S41586-018-0241-9 | 2018-06-20 | ||
5NLX | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.1 | Inactive | 10.1038/S41467-017-00630-4 | 2017-09-27 | |
6UOA | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 6.3 | Intermediate | 10.1038/S41586-020-2408-4 | 2020-06-10 | |
7PIU | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
setmelanotide
pubchem
gtoplig
drug_central
chembl_ligand
drugbank
|
Agonist | 2.6 | Active | 10.1038/S41422-021-00569-8 | 2021-11-17 | |
5ZKP | PTAFR | PAF | Platelet-activating factor | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
foropafant
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.8 | Other | 10.1038/S41594-018-0068-Y | 2018-06-20 | |
7YU6 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2~{R})-2-[5-(2-hex...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41467-022-33121-2 | 2022-10-05 | |
7EPT | AGRD1 | ADGRD1 | ADGRD | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 3.0 | Active | 10.1038/S41586-022-04619-Y | 2022-05-11 | |
5DGY | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Human | Transient_transfection | HEK293S | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monopalmitolein (9.7 MAG) | 5 chems | 5.0-5.0 | 20°C |
Apo (no ligand)
|
Apo (no ligand) | 7.7 | Active | 10.1038/SDATA.2016.21 | 2016-03-23 | |
4L6R | GLR | glucagon | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C | N/A | N/A | 3.3 | Inactive | 10.1038/nature12393 | 2013-07-24 | |
7F1S | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 10.1038/S41467-021-24438-5 | 2021-07-14 | |
2YCY | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | NA | 3 chems | 6.9-7.3 | NA |
(S)-Cyanopindolol
pubchem
|
Antagonist | 3.2 | Inactive | 10.1073/PNAS.1100185108 | 2011-06-08 | ||
7EZK | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCK-8
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 3.1 | Active | 10.1038/S41589-021-00841-3 | 2021-08-25 | |
7EW7 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SEW2871
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.3 | Active | 10.1038/S41422-021-00566-X | 2021-09-29 | |
6KUY | ADA2A | α2A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2~{S})-4-fluoranyl-...
pubchem
|
Agonist (partial) | 3.2 | Inactive | 2019-12-04 | ||
7WVV | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
synthetic peptide
|
Agonist | 2.9 | Active | 10.1038/S41467-022-29361-X | 2022-04-13 | |
6K42 | ADA2B | α2B | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dexmedetomidine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 4.1 | Active | 10.1038/S41589-020-0492-2 | 2020-04-15 | |
5VBL | APJ | apelin | Apelin | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 6.1-6.1 | 20-22°C |
AMG3054
gtoplig
|
Agonist | 2.6 | Inactive | 10.1016/J.STR.2017.04.008 | 2017-05-31 | |
3V2W | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.8-7.8 | 20°C |
W146
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.4 | Inactive | 10.1126/SCIENCE.1215904 | 2012-02-15 | |
7CX3 | PE2R2 | EP2 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
taprenepag
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.8 | Active | 10.1126/SCIADV.ABF1268 | 2021-05-05 | |
7RGP | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
tirzepatide
pubchem
gtoplig
|
Agonist | 2.9 | Active | 10.1073/PNAS.2116506119 | 2022-04-13 | |
7DH5 | ADRB3 | β3 | Adrenoceptors | A (Rhodopsin) | Dog | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
mirabegron
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.2 | Active | 10.1016/J.MOLCEL.2021.06.024 | 2021-08-04 | |
7DHI | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
levosalbutamol
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 3.3 | Active | 10.1093/NSR/NWAA284 | 2020-12-16 | |
5A8E | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 7.0-7.0 | 20°C |
7-methylcyanopindolo...
pubchem
|
Inverse agonist | 2.4 | Inactive | 10.1124/MOL.115.101030 | 2015-09-30 | |
7DD6 | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcium
pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem |
AgonistPAM | 3.2 | Active | 10.1126/SCIADV.ABG1483 | 2021-06-16 | |
8G59 | FFAR4 | FFA4 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
TUG-891
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.6 | Active | 10.1126/SCIENCE.ADD6220 | 2023-03-08 | |
5X93 | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C |
K-8794
pubchem
gtoplig
|
Antagonist | 2.2 | Inactive | 10.1038/NSMB.3450 | 2017-08-16 | |
6LRY | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
sarafotoxin S6b
pubchem
gtoplig
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 3.0 | Inactive | 10.1016/J.BBRC.2019.12.091 | 2020-02-12 | |
7X1U | TRFR | TRH1 | Thyrotropin-releasing hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
TRH
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41422-022-00646-6 | 2022-08-31 | |
7W6P | ADA2A | α2A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-pyridin-4-ylisoqui...
pubchem
|
Agonist | 3.5 | Active | 10.1126/SCIENCE.ABN7065 | 2022-09-28 | |
7VDH | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 48/80
pubchem
gtoplig
|
Agonist | 2.9 | Active | 10.1038/S41586-021-04077-Y | 2021-12-01 | |
8HDP | AA2BR | A2B | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
adenosine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.2 | Active | 10.1038/S41421-022-00503-1 | 2023-01-18 | |
7TYY | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcitonin salmon
pubchem
|
Agonist | 3.0 | Active | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | |
7XTC | 5HT7R | 5-HT7 | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-CT
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.2 | Active | 10.1016/J.MOLCEL.2022.05.031 | 2022-07-27 | |
7DTU | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-tryptophan
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
PAM | 4.4 | Intermediate | 2021-03-10 | ||
5K2C | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.9 | Inactive | 10.1126/SCIADV.1600292 | 2016-09-21 | |
7YAC | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Paltusotine
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41467-023-36673-Z | 2023-04-19 | |
7MT9 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (all-trans)
pubchem
|
Agonist | 7.0 | Active | 10.1038/S41586-021-03721-X | 2021-07-07 | |
2J4Y | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Transient_transfection | COS1 | Mammalian | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 3 chems | 7.5-7.5 | 4°C |
Retinal (11-cis)
pubchem
|
Inverse agonist | 3.4 | Inactive | 10.1016/J.JMB.2007.03.007 | 2007-09-25 | ||
8E9X | ACM4 | M4 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL73538
chembl_ligand
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41586-022-05489-0 | 2022-11-30 | |
7WY5 | AGRL3 | ADGRL3 | ADGRL | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 10.1016/J.MOLCEL.2022.10.009 | 2022-10-26 | |
7EXD | 5HT1F | 5-HT1F | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lasmiditan
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 3.4 | Active | 10.1038/S41422-021-00527-4 | 2021-08-04 | |
7SK4 | ACKR3 | ACKR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Stromal cell-derived...
|
Agonist | 3.3 | Active | 10.1126/SCIADV.ABN8063 | 2022-07-27 | |
5X33 | Q9WTK1 | BLT1 | Leukotriene | A (Rhodopsin) | Guinea pig | Pichia Pastoris | P. pastoris SMD1163 | Yeast | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 8.5-9.0 | 4°C |
BIIL 260
pubchem
gtoplig
|
Antagonist | 3.7 | Inactive | 10.1038/NCHEMBIO.2547 | 2018-01-03 | |
7RKF | US28 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Fractalkine
pubchem
|
Agonist | 4.0 | Active | 10.1126/SCIADV.ABL5442 | 2022-01-26 | |
5UNG | AGTR2 | AT2 | Angiotensin | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 8.0-8.0 | 20°C |
compound 1 [PMID: 28...
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.8 | Active | 10.1038/NATURE22035 | 2017-04-05 | |
1F88 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 2 chemicals | 2 steps | vapour diffusion | Hanging drop | 7 chems | 6.0-6.0 | 4°C |
Retinal (11-cis)
pubchem
|
Inverse agonist | 2.8 | Inactive | 10.1126/SCIENCE.289.5480.739 | 2000-08-04 | ||
7XBD | GALR2 | GAL2 | Galanin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Galanin, Human
pubchem
|
Agonist | 3.1 | Active | 10.1371/JOURNAL.PBIO.3001714 | 2022-07-13 | |
7T2G | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL58362
chembl_ligand
pubchem
|
Agonist | 2.5 | Active | 10.1038/S41589-022-01208-Y | 2022-12-07 | |
7XMR | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SOMATOSTATIN
chembl_ligand
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41422-022-00679-X | 2022-08-03 | |
7F8V | GASR | CCK2 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
desulfated gastrin-1...
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41589-021-00866-8 | 2021-10-13 | |
7DTV | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcium
pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem |
AgonistPAM | 3.5 | Active | 10.1038/S41422-021-00474-0 | 2021-03-10 | |
7DGE | GRM1 | mGlu1 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
quisqualate
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
pubchem
|
Agonist | 3.7 | Intermediate | 10.1007/S13238-020-00808-5 | 2021-09-22 | |
4BEZ | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Stable_cells | HEK293S-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 4 chems | 4.5-4.5 | 20°C |
Apo (no ligand)
|
Apo (no ligand) | 3.3 | Active | 10.1038/EMBOR.2013.44 | 2013-04-24 | ||
7XW5 | TSHR | TSH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Glycoprotein hormone...
Thyrotropin subunit ... N-[4-[[5-[(2S)-3-ben... pubchem |
AgonistAgonistPAM | 3.0 | Active | 10.1038/S41586-022-05173-3 | 2022-08-24 | |
7XA3 | CCR2 | CCR2 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
C-C motif chemokine ...
|
Agonist | 2.9 | Active | 10.1038/S41421-022-00403-4 | 2022-08-24 | |
7WYB | AGRL3 | ADGRL3 | ADGRL | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.0 | Active | 10.1016/J.MOLCEL.2022.10.009 | 2022-10-26 | |
7XOW | GASR | CCK2 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
desulfated gastrin-1...
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41421-022-00420-3 | 2022-07-20 | |
6AQF | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Pichia Pastoris | P. pastoris SMD1163 | Yeast | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.5 | Inactive | 10.1016/J.CELL.2017.12.004 | 2018-01-10 | |
7Y64 | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
C5a anaphylatoxin
|
Agonist | 2.9 | Active | 10.1038/S41422-023-00779-2 | 2023-03-01 | |
6WW2 | FZD5 | FZD5 | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.7 | Inactive | 10.7554/ELIFE.58464 | 2020-08-19 | |
4PHU | FFAR1 | FFA1 | Free fatty acid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.6-7.6 | 20°C |
fasiglifam
pubchem
gtoplig
chembl_ligand
drugbank
|
Allosteric agonist | 2.3 | Intermediate | 10.1038/NATURE13494 | 2014-07-16 | |
7E9H | GRM4 | mGlu4 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-serine-O-phosphate
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 4.0 | Intermediate | 10.1038/S41586-021-03495-2 | 2021-06-23 | |
7YP7 | AGRG2 | ADGRG2 | ADGRG | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 2022-08-24 | ||
5K2D | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.9 | Inactive | 10.1126/SCIADV.1600292 | 2016-09-21 | |
7T6T | FPR1 | FPR1 | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
synthetic peptide
|
Agonist | 3.2 | Active | 10.1038/S41467-022-28586-0 | 2022-03-30 | |
6N52 | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 4.0 | Inactive | 10.1038/S41586-019-0881-4 | 2019-01-23 | |
5OLO | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
tozadenant
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 3.1 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
5OLV | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
CHEMBL1671936
chembl_ligand
pubchem
|
Antagonist | 2.0 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
6NBH | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Long-acting parathyr...
|
Agonist | 3.5 | Active | 10.1126/SCIENCE.AAV7942 | 2019-04-17 | |
8DCS | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
4-{[(2S)-3-(tert-but...
pubchem
|
Agonist | 2.5 | Active | 10.1038/S41467-022-31823-1 | 2022-07-27 | |
8EFB | OPRM | μ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
OLICERIDINE
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | |
6UUS | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Adrenomedullin
pubchem
|
Agonist | 2.4 | Active | 10.1021/ACSPTSCI.9B00080 | 2020-04-01 | |
8IW1 | TAAR9 | TAAR9 | A orphans | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-Phenylethanaminium
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-023-06106-4 | 2023-05-31 | |
8FLR | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PTHrP[1-36]
|
Agonist | 2.9 | Active | 10.1016/J.STR.2023.04.002 | 2023-04-26 | |
7PP1 | P2Y12 | P2Y12 | P2Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
selatogrel
pubchem
|
Antagonist | 2.8 | Intermediate | 10.1016/j.bcp.2022.115291 | 2022-11-02 | |
6ZG9 | ACM1 | M1 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
7-fluoro-5-methyl-3-...
pubchem
|
Agonist | 2.5 | Inactive | 10.1016/J.CELL.2021.11.001 | 2021-10-06 | |
7T9M | TSHR | TSH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CS-17 heavy chain
CS-17 light chain |
Inverse agonistInverse agonist | 3.1 | Inactive | 10.1038/S41586-022-05159-1 | 2022-08-10 | |
6LI2 | GPR52 | GPR52 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Inactive | 10.1038/S41586-020-2019-0 | 2020-02-26 | |
7X2F | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
mevidalen
pubchem
gtoplig
chembl_ligand
dopamine pubchem gtoplig chembl_ligand drugbank drug_central |
PAMAgonist | 3.0 | Active | 10.1038/S41467-022-30929-W | 2022-06-15 | |
8DZR | OPRK | κ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL277863
chembl_ligand
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41586-023-06030-7 | 2023-05-03 | |
7VVJ | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PTHrP[1-36]
|
Agonist | 3.2 | Active | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | |
6K41 | ADA2B | α2B | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dexmedetomidine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.9 | Active | 10.1038/S41589-020-0492-2 | 2020-04-15 | |
7XT8 | 5HT4R | 5-HT4 | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-hydroxytryptamine
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.1 | Active | 10.1016/J.MOLCEL.2022.05.031 | 2022-07-27 | |
7NA8 | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ibutamoren
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.7 | Active | 10.1038/S41467-021-26735-5 | 2021-12-15 | |
6TQ9 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SB-408124
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.7 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
7L0P | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 4.1 | Active | 10.1038/S41594-020-00554-6 | 2021-01-06 | |
7D68 | GLP2R | GLP-2 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
glucagon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
pubchem
pubchem
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41422-020-00442-0 | 2020-12-16 | |
7WU5 | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.0 | Active | 10.1038/S41586-022-04580-W | 2022-04-27 | |
7WI6 | GRM3 | mGlu3 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 3.7 | Inactive | 10.1038/S41422-022-00623-Z | 2022-03-16 | |
7CKY | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3697578
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | |
7WVU | FPR1 | FPR1 | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
FME-LEU-PHE
|
Agonist | 3.3 | Active | 10.1038/S41467-022-29361-X | 2022-04-13 | |
7EVY | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
siponimod
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 3.0 | Active | 10.1038/S41422-021-00566-X | 2021-09-29 | |
6E3Y | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcitonin gene-rela...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-018-0535-Y | 2018-09-19 | |
6RZ6 | CLTR2 | CysLT2 | Leukotriene | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ONO-2570366
pubchem
gtoplig
|
Antagonist | 2.4 | Intermediate | 10.1038/S41467-019-13348-2 | 2019-12-11 | |
7EZC | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
UK-432,097
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.8 | Active | 10.1107/S2052252522001907 | 2022-04-13 | |
7UM6 | 5HT5A | 5-HT5A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lisuride
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.8 | Active | 10.1038/S41594-022-00796-6 | 2022-07-20 | |
8ID8 | FFAR4 | FFA4 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
TUG-891
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 10.1126/SCIENCE.ADD6220 | 2023-03-15 | |
6LMK | GLR | glucagon | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
glucagon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
pubchem
pubchem
pubchem
|
Agonist | 3.7 | Active | 10.1126/SCIENCE.AAZ5346 | 2020-04-01 | |
7TYW | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcitonin salmon
pubchem
|
Agonist | 3.0 | Active | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | |
6H7N | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(S)-Xamoterol
pubchem
|
Agonist | 2.5 | Active | 10.1101/436212 | 2018-10-17 | |
7LD4 | AA1R | A1 | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
adenosine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.3 | Active | 10.1038/S41586-021-03897-2 | 2021-09-08 | |
7L0S | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 4.5 | Active | 10.1038/S41594-020-00554-6 | 2021-01-06 | |
7U2L | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-(5-carbamimidamido...
|
Agonist | 3.2 | Active | 10.1038/S41586-022-05588-Y | 2022-05-04 | |
7T6U | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
synthetic peptide
|
Agonist | 2.9 | Active | 10.1038/S41467-022-28586-0 | 2022-03-30 | |
6WIV | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2R)-3-[(Z)-icos-11...
pubchem
(2R)-3-{[(S)-(2-amin... pubchem |
NAMNAM | 3.3 | Inactive | 10.1038/S41586-020-2452-0 | 2020-07-01 | |
7ZI0 | SMO | SMO | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
3-chloro-N-[trans-4-...
pubchem
|
Antagonist | 3.0 | Inactive | 10.1126/SCIADV.ABM5563 | 2022-06-15 | |
7TYO | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcitonin human
pubchem
|
Agonist | 2.7 | Active | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | |
4PXF | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 3 chems | 6.0-6.0 | 4°C |
B-Octylglucoside
pubchem
|
unknown | 2.8 | Active | 10.1038/NCOMMS5801 | 2014-09-17 | ||
6PS3 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3799125
chembl_ligand
pubchem
|
Antagonist | 2.5 | Inactive | 10.1107/S2052252519013137 | 2019-11-13 | |
7VBI | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
tirzepatide
pubchem
gtoplig
|
Agonist | 3.0 | Active | 10.1038/S41467-022-28683-0 | 2022-03-02 | |
7WUI | AGRG2 | ADGRG2 | ADGRG | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
IP15
|
Agonist | 3.1 | Active | 10.1038/S41586-022-04590-8 | 2022-04-27 | |
7V6A | ACM4 | M4 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
methyl 4-[4-(3-methy...
pubchem
|
Allosteric agonist | 3.6 | Active | 10.1038/S41467-022-30595-Y | 2022-05-11 | |
6WH4 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL428892
chembl_ligand
pubchem
|
Inverse agonist | 3.4 | Inactive | 10.1016/J.CELL.2020.08.024 | 2020-09-23 | |
7KI0 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
semaglutide
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
|
Agonist | 2.5 | Active | 10.1016/J.CELREP.2021.109374 | 2021-08-04 | |
4DJH | OPRK | κ | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
JDTic
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.9 | Inactive | 10.1038/NATURE10939 | 2012-03-21 | |
5U09 | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 9 chemicals | 9 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20°C |
taranabant
pubchem
gtoplig
chembl_ligand
drugbank
|
Inverse agonist | 2.6 | Inactive | 10.1038/NATURE20613 | 2016-12-07 | |
7CA5 | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 7.6 | Inactive | 10.1016/J.JMB.2020.09.023 | 2020-11-11 | |
7RA3 | GIPR | GIP | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
gastric inhibitory p...
pubchem
|
Agonist | 3.2 | Active | 10.1073/PNAS.2116506119 | 2022-04-13 | |
7S8N | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(R)-ZINC-3573
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.9 | Active | 10.1038/S41586-021-04126-6 | 2021-11-17 | |
2Y03 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 6 chems | 8.5-8.5 | 4°C |
LEVISOPRENALINE
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 2.9 | Inactive | 10.1038/NATURE09746 | 2011-01-12 | ||
8IRT | DRD3 | D3 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
rotigotine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.7 | Active | 10.1038/S41422-023-00808-0 | 2023-06-07 | |
8IA8 | C3AR | C3a | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ALA-SER-LYS-LEU-GLY-...
|
Agonist | 2.9 | Active | 2023-05-24 | ||
7XBW | CX3C1 | CX3CR1 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 10.1126/SCIADV.ABN8048 | 2022-07-13 | |
6WQA | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.0 | Inactive | 10.1107/S2052252520012701 | 2020-11-18 | |
6GPS | CCR2 | CCR2 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MK-0812
pubchem
|
Antagonist | 3.3 | Inactive | 10.1016/J.STR.2018.10.027 | 2019-01-02 | |
7KH0 | V2R | V2 | Vasopressin and oxytocin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
vasopressin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.8 | Active | 10.1038/S41422-021-00483-Z | 2021-05-26 | |
6IBB | SUCR1 | succinate | Succinate | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 2.1 | Active | 10.1038/S41586-019-1663-8 | 2019-08-14 | |
7X9C | NPY4R | Y4 | Neuropeptide Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Pancreatic polypepti...
pubchem
|
Agonist | 3.0 | Active | 10.1126/SCIADV.ABM1232 | 2022-05-18 | |
7WXU | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1038/S41467-022-33173-4 | 2022-09-28 | |
6FKC | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
3-[1'-[(2~{S})-2-(4-...
pubchem
|
Agonist | 2.5 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
7S8O | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(R)-ZINC-3573
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.6 | Active | 10.1038/S41586-021-04126-6 | 2021-11-17 | |
4AMI | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | sitting drops | 3 chems | 9.0-9.0 | 4°C |
Bucindolol
pubchem
|
Agonist | 3.2 | Inactive | 10.1016/J.STR.2012.03.014 | 2012-05-23 | ||
5ZKQ | PTAFR | PAF | Platelet-activating factor | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ABT-491
pubchem
gtoplig
chembl_ligand
|
Inverse agonist | 2.9 | Intermediate | 10.1038/S41594-018-0068-Y | 2018-06-20 | |
6OMM | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL552527
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41467-020-14728-9 | 2020-02-26 | |
7F61 | HRH3 | H3 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-ethyl-3-fluoro-3-[...
pubchem
|
Antagonist | 2.6 | Inactive | 10.1038/S41467-022-33880-Y | 2022-10-26 | |
6JZH | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.3 | Inactive | 10.1107/S1600576719012846 | 2019-10-30 | |
4MQS | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.2-7.9 | 20°C |
iperoxo
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.5 | Active | 10.1038/NATURE12735 | 2013-11-27 | |
7W0M | APJ | apelin | Apelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(1R,2S)-N-[4-(2,6-di...
pubchem
|
Agonist | 3.7 | Active | 10.1038/S41594-022-00797-5 | 2022-07-27 | |
5IU4 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20 |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.7 | Inactive | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | |
7XKF | AGRG2 | ADGRG2 | ADGRG | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PRASTERONE
chembl_ligand
pubchem
|
Agonist | 2.4 | Active | 10.1038/S41589-022-01084-6 | 2022-08-10 | |
7AD3 | STE2 | STE2 | STE2 | D1 (Ste2-like fungal pheromone) | strain ATCC 204508 / S288c | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Alpha-factor mating ...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-020-2994-1 | 2020-12-09 | |
6H7J | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LEVISOPRENALINE
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | |
6WZG | SCTR | secretin | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SECRETIN
chembl_ligand
pubchem
|
Agonist | 2.3 | Active | 10.1038/S41467-020-17791-4 | 2020-08-12 | |
8GUQ | CNR2 | CB2 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
olorinab
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.1 | Active | 10.1038/S41467-023-37112-9 | 2023-05-10 | |
4QKX | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | 7.7 MAG | 5 chems | 7.8-8.4 | 20°C |
Q27453560
pubchem
|
Agonist | 3.3 | Active | 10.1073/PNAS.1410415111 | 2014-07-23 | |
6FK8 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
(2~{R},3~{S})-3-azan...
pubchem
|
Agonist | 2.9 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
4XNV | P2RY1 | P2Y1 | P2Y | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.5-6.5 | 20°C |
BMS compound 16 [PMI...
pubchem
gtoplig
chembl_ligand
|
NAM | 2.2 | Intermediate | 10.1038/NATURE14287 | 2015-04-01 | |
7EVZ | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
cenerimod
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.1 | Active | 10.1038/S41422-021-00566-X | 2021-09-29 | |
7WJ5 | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SOMATOSTATIN
chembl_ligand
pubchem
|
Agonist | 3.7 | Active | 10.7554/ELIFE.76823 | 2022-07-13 | |
8E3Y | VIPR1 | VPAC1 | VIP and PACAP | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[Ac-His<sup>1</sup>]...
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.3 | Active | 10.1038/S41467-022-34629-3 | 2022-11-23 | |
3OE0 | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
CVX15
|
Antagonist | 2.9 | Inactive | 10.1126/SCIENCE.1194396 | 2010-10-27 | |
5UVI | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 3.2 | Inactive | 10.1107/S205225251700570X | 2017-05-24 | |
8ITF | TAAR9 | TAAR9 | A orphans | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N,N-Dimethylcyclohex...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-023-06106-4 | 2023-05-31 | |
7DGD | GRM1 | mGlu1 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 4.0 | Inactive | 10.1007/S13238-020-00808-5 | 2021-09-22 | |
4QIM | SMO | SMO | Frizzled | F (Frizzled) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 7.2-7.2 | 20°C |
ANTA XV
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.6 | Inactive | 10.1038/NCOMMS5355 | 2014-07-23 | |
4Z9G | CRFR1 | CRF1 | Corticotropin-releasing factor | B1 (Secretin) | Human | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-5.5 | 23°C |
CP 376,395
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.2 | Inactive | 10.2174/1874467210666170110114727 | 2016-06-29 | |
7S15 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL5191519
chembl_ligand
pubchem
|
Agonist | 3.8 | Active | 10.1021/acs.jmedchem.1c01856 | 2022-06-08 | |
7LLL | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
exendin-4
pubchem
gtoplig
pubchem
|
Agonist | 3.7 | Active | 10.1038/S41467-021-27760-0 | 2022-01-12 | |
7JNI | AGTR2 | AT2 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
olodanrigan
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 3.0 | Active | 10.1073/PNAS.2116289119 | 2022-02-09 | |
7C7Q | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(-)-baclofen
pubchem
gtoplig
chembl_ligand
drugbank
drugbank
gtoplig
pubchem
BHFF pubchem |
AgonistPAM | 3.0 | Active | 10.1038/S41422-020-0350-5 | 2020-07-01 | |
7RMI | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 3.2 | Active | 10.1038/S41589-021-00890-8 | 2021-11-03 | |
4XT3 | US28 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monovaccenin(11.7 MAG) | 6 chems | 7.4-7.4 | 20°C |
CX3CL1
gtoplig
|
Agonist (partial) | 3.8 | Active | 10.1126/SCIENCE.AAA5026 | 2015-03-04 | |
6DDE | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | Cryo-EM | Gatan K2 Summit direct electron camera , 300kV | 5 chems | 7.5-7.5 | 4°C |
DAMGO
pubchem
gtoplig
chembl_ligand
chembl_ligand
|
Agonist | 3.5 | Active | 10.1038/S41586-018-0219-7 | 2018-06-13 | ||
7F8U | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lintitript
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.8 | Inactive | 10.1038/S41589-021-00866-8 | 2021-10-13 | |
7XJJ | GALR1 | GAL1 | Galanin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
galanin
gtoplig
chembl_ligand
gtoplig
pubchem
pubchem
pubchem
pubchem
pubchem
|
Agonist | 3.3 | Active | 2023-05-03 | ||
7YU4 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2~{R})-2-[5-(2-hex...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41467-022-33121-2 | 2022-10-05 | |
7YU5 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2~{R})-2-[5-(2-hex...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41467-022-33121-2 | 2022-10-05 | |
5EN0 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Stable_cells | HEK293S(TetR)GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Sitting drop | 4 chems | 5.0-5.0 | 4°C |
Retinal (all-trans)
pubchem
|
Agonist | 2.8 | Active | 10.15252/EMBR.201642671 | 2016-08-10 | ||
8HBD | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
sovateltide
pubchem
gtoplig
chembl_ligand
gtoplig
pubchem
pubchem
|
Agonist | 3.0 | Active | 2023-03-22 | ||
4N6H | OPRD | δ | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 6.1-6.2 | 20-23°C |
naltrindole
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 1.8 | Inactive | 10.1038/NATURE12944 | 2013-12-25 | |
6TPJ | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
suvorexant
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Antagonist | 2.7 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
6ME3 | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL15060
chembl_ligand
pubchem
|
Agonist | 2.9 | Inactive | 10.1038/S41586-019-1141-3 | 2019-04-24 | |
2YDO | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 4 chemicals | 4 steps | vapour diffusion | sitting drop | 5 chems | 7.6-7.6 | 4°C |
adenosine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.0 | Active | 10.1038/NATURE10136 | 2011-05-18 | ||
7T6B | S1PR2 | S1P2 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
sphingosine 1-phosph...
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1126/SCIADV.ABN0067 | 2022-04-06 | |
6X1A | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
danuglipron
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.5 | Active | 10.1016/J.MOLCEL.2020.09.020 | 2020-09-09 | |
4BWB | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | NA | E. coli BL21(DE3) | Bacteria | 3 chemicals | 3 steps | vapour diffusion | sitting drops | 7 chems | 5.5-5.5 | 4°C |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 3.6 | Inactive | 10.1073/PNAS.1317903111 | 2014-01-29 | ||
7FD9 | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 4.0 | Inactive | 10.1016/J.CELREP.2021.109648 | 2021-09-08 | |
5L7I | SMO | SMO | Frizzled | F (Frizzled) | Human | Transient_transfection | HEK293S(TetR)-GnTI- | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 8 chems | 6.0-6.0 | 20°C |
vismodegib
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Antagonist | 3.3 | Inactive | 10.1038/NATURE18934 | 2016-07-20 | |
7VL8 | CCR1 | CCR1 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1038/S41589-021-00918-Z | 2022-03-23 | |
7WCN | GP119 | GPR119 | GPR18, GPR55 and GPR119 | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AR231453
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.9 | Active | 10.1038/S41467-022-34696-6 | 2022-12-21 | |
7X2V | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 10.1038/S41467-022-33173-4 | 2022-09-28 | |
7LCI | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
danuglipron
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.9 | Active | 10.1016/J.STR.2021.04.008 | 2021-01-20 | |
7EO2 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(S)-FTY720-phosphate
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.9 | Active | 10.1038/S41589-021-00930-3 | 2022-01-05 | |
7CFM | GPBAR | GPBA | Bile acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL2331646
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41586-020-2569-1 | 2020-09-09 | |
6B3J | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 2 chemicals | 2 steps | Cryo-EM | Volta phase plate (FEI) | 5 chems | 7.4-7.4 | 4°C |
Exendin-P5
|
Agonist | 3.3 | Active | 10.1038/NATURE25773 | 2018-02-21 | ||
8HK5 | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
C5a
gtoplig
|
Agonist | 3.0 | Active | 10.1038/S41589-023-01339-W | 2023-05-10 | |
3DQB | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | hanging drops | 5 chems | 5.9-6.1 | 10°C |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 10.1038/NATURE07330 | 2008-09-23 | ||
7Y14 | MRGRD | MRGPRD | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
β-alanine
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
|
Agonist | 3.2 | Active | 10.1038/S42003-022-03668-3 | 2022-07-20 | |
3PDS | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 3 chemicals | 3 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.7-6.7 | 20°C |
FAUC50
pubchem
|
Agonist | 3.5 | Inactive | 10.1038/NATURE09665 | 2011-01-12 | |
6M1I | PACR | PAC1 | VIP and PACAP | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[Ac-His<sup>1</sup>]...
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41422-020-0280-2 | 2020-03-11 | |
4RWD | OPRD | δ | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
DIPP-NH2
|
Antagonist | 2.7 | Inactive | 10.1038/NSMB.2965 | 2015-01-14 | |
7LJC | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
mevidalen
pubchem
gtoplig
chembl_ligand
CHEMBL1160787 chembl_ligand pubchem |
PAMAgonist | 3.0 | Active | 10.1038/S41422-021-00482-0 | 2021-03-03 | |
4N4W | SMO | SMO | Frizzled | F (Frizzled) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 6.9-6.9 | 20°C |
SANT-1
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.8 | Inactive | 10.1038/NCOMMS5355 | 2014-01-22 | |
6TQ7 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SB-334867
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.7 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
7MTB | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (all-trans)
pubchem
|
Agonist | 4.0 | Active | 10.1038/S41586-021-03721-X | 2021-07-07 | |
6PH7 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Nerol
pubchem
|
unknown | 2.9 | Active | 2020-07-01 | ||
7EWR | GP158 | GPR158 | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 4.7 | Inactive | 10.1038/S41467-021-27147-1 | 2021-12-01 | |
5NX2 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | vapour diffusion | Sitting drop | 4 chems | 8.0-9.0 | 10°C |
Truncated protein ag...
|
Agonist | 3.7 | Intermediate | 10.1038/NATURE22800 | 2017-06-14 | ||
5CGC | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-6.8 | 20°C |
CHEMBL3603915
chembl_ligand
pubchem
|
NAM | 3.1 | Inactive | 10.1021/acs.jmedchem.5b00892 | 2015-08-12 | |
7T11 | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Octreotide
|
Agonist | 2.7 | Active | 10.1038/S41594-022-00727-5 | 2022-03-09 | |
8FLQ | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Parathyroid hormone
|
Agonist | 2.6 | Active | 10.1016/J.STR.2023.04.002 | 2023-04-26 | |
8G2Y | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[1-Myristoyl-glycero...
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41467-023-38083-7 | 2023-05-10 | |
5ZBH | NPY1R | Y1 | Neuropeptide Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
BMS-193885
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/S41586-018-0046-X | 2018-04-25 | |
7VGY | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-iodo-melatonin
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.1 | Active | 10.1038/S41467-022-28111-3 | 2022-03-02 | |
2YCZ | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | NA | 3 chems | 6.9-7.3 | NA |
Iodocyanopindolol
pubchem
|
Antagonist | 3.7 | Inactive | 10.1073/PNAS.1100185108 | 2011-06-01 | ||
7T2H | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LOFENTANIL
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41589-022-01208-Y | 2022-12-07 | |
7BR3 | GNRHR | GnRH1 | Gonadotrophin-releasing hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
elagolix
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Antagonist | 2.8 | Inactive | 10.1038/S41467-020-19109-W | 2020-10-07 | |
5IUA | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20 |
2-(Furan-2-yl)-5-N-[...
pubchem
|
Antagonist | 2.2 | Inactive | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | |
5TGZ | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | Transient_transfection | HEK293F | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.4 | 20°C |
AM6538
pubchem
gtoplig
|
Antagonist | 2.8 | Inactive | 10.1016/J.CELL.2016.10.004 | 2016-11-02 | |
6OS0 | AGTR1 | AT1 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
angiotensin II
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
pubchem
|
Agonist | 2.9 | Active | 10.1126/SCIENCE.AAY9813 | 2020-02-19 | |
5UIW | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.3-6.3 | 20°C |
5P7-CCL5
|
Antagonist | 2.2 | Inactive | 10.1016/J.IMMUNI.2017.05.002 | 2017-06-28 | |
7EB2 | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
BHFF
pubchem
(-)-baclofen pubchem gtoplig chembl_ligand drugbank drugbank gtoplig pubchem |
PAMAgonist | 3.5 | Active | 10.1038/S41586-021-03507-1 | 2021-05-05 | |
7VVL | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
teriparatide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
pubchem
pubchem
pubchem
pubchem
|
Agonist | 2.8 | Active | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | |
7MTQ | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 3.7 | Inactive | 10.1038/S41586-021-03680-3 | 2021-07-07 | |
7UM5 | 5HT5A | 5-HT5A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-CT
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.7 | Active | 10.1038/S41594-022-00796-6 | 2022-07-20 | |
3PQR | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 3 chems | 5.6-5.6 | 4°C |
Retinal (all-trans)
pubchem
|
Agonist | 2.9 | Active | 10.1038/NATURE09789 | 2011-03-09 | ||
7SF8 | AGRG1 | ADGRG1 | ADGRG | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.7 | Active | 10.1038/S41586-022-04575-7 | 2022-04-27 | |
5L7D | SMO | SMO | Frizzled | F (Frizzled) | Human | Transient_transfection | HEK293S(TetR)-GnTI- | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 4.0-4.0 | 20°C | N/A | N/A | 3.2 | Inactive | 10.1038/NATURE18934 | 2016-07-20 | |
7EVM | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-Tert-butyl-6,7-dic...
pubchem
|
Ago-PAM | 2.5 | Active | 10.1038/S41467-021-24058-Z | 2021-08-11 | |
7YK7 | RL3R2 | RXFP4 | Relaxin family peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
DC591053
pubchem
gtoplig
|
Agonist | 2.8 | Active | 10.1038/S41467-023-36182-Z | 2023-03-01 | |
2Y04 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 6 chems | 9.0-9.0 | 4°C |
levosalbutamol
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist (partial) | 3.1 | Inactive | 10.1038/NATURE09746 | 2011-01-12 | ||
7FIH | LSHR | LH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Choriogonadotropin b...
gtoplig
Glycoprotein alpha gtoplig 5-Amino-N-(1,1-dimet... pubchem |
AgonistAgonistAllosteric agonist | 3.2 | Active | 10.1038/S41586-021-03924-2 | 2021-09-29 | |
7T10 | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SOMATOSTATIN
chembl_ligand
pubchem
|
Agonist | 2.5 | Active | 10.1038/S41594-022-00727-5 | 2022-03-09 | |
7TYF | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
amylin peptide
|
Agonist | 2.2 | Active | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | |
7B6W | ADA1B | α1B | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(+)-cyclazosin
pubchem
gtoplig
chembl_ligand
|
Inverse agonist | 2.9 | Inactive | 10.1038/s41467-021-27911-3 | 2022-01-12 | |
7SRS | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Lysergide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.3 | Active | 10.1016/J.NEURON.2022.08.006 | 2022-09-21 | |
7TRY | CRFR2 | CRF2 | Corticotropin-releasing factor | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Urocortin
pubchem
|
Agonist | 3.7 | Active | 10.1038/S41467-022-33851-3 | 2022-11-09 | |
7EW3 | S1PR3 | S1P3 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Sphingosine 1-phosph...
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41422-021-00567-W | 2021-09-29 | |
7WUQ | AGRG2 | ADGRG2 | ADGRG | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 2.9 | Active | 10.1038/S41586-022-04590-8 | 2022-04-27 | |
7JVR | DRD2 | D2 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
bromocriptine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.8 | Active | 10.1016/J.CELL.2021.01.027 | 2021-02-24 | |
7BB6 | V2R | V2 | Vasopressin and oxytocin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
vasopressin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 4.2 | Active | 10.1126/SCIADV.ABG5628 | 2021-06-02 | |
4ZUD | AGTR1 | AT1 | Angiotensin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-5.0 | 20°C |
OLMESARTAN
chembl_ligand
pubchem
|
Inverse agonist | 2.8 | Inactive | 10.1074/JBC.M115.689000 | 2015-10-07 | |
8EFO | OPRM | μ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PZM21
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.8 | Active | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | |
7VUI | GP139 | GPR139 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JNJ-63533054
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.3 | Active | 10.1038/S41422-021-00591-W | 2021-12-29 | |
7Y67 | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
C089
|
Agonist | 2.8 | Active | 10.1038/S41422-023-00779-2 | 2023-03-01 | |
7DHR | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LEVISOPRENALINE
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 3.8 | Active | 10.1093/NSR/NWAA284 | 2020-12-16 | |
5GLH | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | Baculovirus | SF+ | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.0-6.0 | 20°C |
ENDOTHELIN
chembl_ligand
pubchem
|
Agonist | 2.8 | Inactive | 10.1038/nature19319 | 2016-09-07 | |
6LFM | CXCR2 | CXCR2 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Interleukin-8
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-020-2492-5 | 2020-09-02 | |
5EE7 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | Transient_transfection | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-6.5 | 20°C |
MK-0893
pubchem
gtoplig
chembl_ligand
drugbank
Octaethylene glycol ... pubchem |
NAMAntagonist | 2.5 | Inactive | 10.1038/NATURE17414 | 2016-04-20 | |
6X18 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL410972
chembl_ligand
pubchem
pubchem
|
Agonist | 2.1 | Active | 10.1016/J.MOLCEL.2020.09.020 | 2020-09-09 | |
7F6G | AGTR1 | AT1 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SAR1-AngII
|
Agonist | 2.9 | Active | 2023-03-29 | ||
4QIN | SMO | SMO | Frizzled | F (Frizzled) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 6 chems | 7.2-7.2 | 20°C |
SAG1.5
pubchem
|
Agonist | 2.6 | Inactive | 10.1038/NCOMMS5355 | 2014-07-23 | |
6LFO | CXCR2 | CXCR2 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Interleukin-8
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-020-2492-5 | 2020-09-02 | |
6IIU | TA2R | TP | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ramatroban
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
gtoplig
|
Antagonist | 2.5 | Intermediate | 10.1038/S41589-018-0170-9 | 2018-12-19 | |
7EJK | ADA2A | α2A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
oxymetazoline
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.4 | Active | 10.1126/SCIADV.ABJ5347 | 2022-04-13 | |
7XY6 | AA2BR | A2B | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
BAY 60-6583
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 10.1126/SCIADV.ADD3709 | 2023-05-03 | |
7XXI | P2Y12 | P2Y12 | P2Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2MeSADP
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 3.0 | Active | 2023-06-07 | ||
7WU4 | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.4 | Active | 10.1038/S41586-022-04580-W | 2022-04-27 | |
7BU7 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1615159
chembl_ligand
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41422-020-00424-2 | 2020-12-02 | |
7CFN | GPBAR | GPBA | Bile acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
INT-777
pubchem
INT-777 pubchem |
AgonistPAM | 3.0 | Active | 10.1038/S41586-020-2569-1 | 2020-09-09 | |
7BW0 | GPBAR | GPBA | Bile acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 3.9 | Active | 10.1038/S41392-020-00262-Z | 2020-09-02 | |
8FYN | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.0 | Inactive | 10.1038/S41467-023-36733-4 | 2023-03-08 | |
8EF6 | OPRM | μ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
morphine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | |
6ZFZ | ACM1 | M1 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3354065
chembl_ligand
pubchem
|
Agonist | 2.2 | Inactive | 10.1016/J.CELL.2021.11.001 | 2021-10-06 | |
5TZY | FFAR1 | FFA1 | Free fatty acid | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.3-6.8 | 20°C |
MK-8666
chembl_ligand
pubchem
(2S,3R)-3-Cyclopropy... pubchem |
AgonistPAM | 3.2 | Intermediate | 10.1038/NSMB.3417 | 2017-06-07 | |
8IWE | TAAR9 | TAAR9 | A orphans | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SPERMIDINE
chembl_ligand
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-023-06106-4 | 2023-05-31 | |
8DCR | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Dobutamine
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41467-022-31823-1 | 2022-07-27 | |
7UM4 | 5HT5A | 5-HT5A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3654198
chembl_ligand
pubchem
|
Antagonist | 2.8 | Inactive | 10.1038/S41594-022-00796-6 | 2022-07-20 | |
6TPG | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
EMPA
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.7 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
8GUR | CNR2 | CB2 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CP55940
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 2.8 | Active | 10.1038/S41467-023-37112-9 | 2023-05-10 | |
5OM1 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
CHEMBL2024114
chembl_ligand
pubchem
|
Antagonist | 2.1 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
7F4H | MSHR | MC1 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL407070
chembl_ligand
pubchem
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41422-021-00557-Y | 2021-09-08 | |
8DPH | 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lorcaserin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.2 | Active | 10.1016/J.CELREP.2022.111211 | 2022-08-24 | |
7EO4 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
siponimod
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 2.9 | Active | 10.1038/S41589-021-00930-3 | 2022-01-05 | |
7XMT | SSR4 | SST4 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
J-2156
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.8 | Active | 10.1038/S41422-022-00679-X | 2022-08-03 | |
3UON | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.5-7.5 | 19.85°C |
CHEMBL558910
chembl_ligand
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/NATURE10753 | 2012-02-01 | |
7UM7 | 5HT5A | 5-HT5A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
methylergonovine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.8 | Active | 10.1038/S41594-022-00796-6 | 2022-07-20 | |
7MBX | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL216166
chembl_ligand
pubchem
|
Agonist | 2.0 | Active | 10.1371/JOURNAL.PBIO.3001295 | 2021-05-26 | |
7E9G | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JNJ-40411813
pubchem
gtoplig
chembl_ligand
drugbank
eglumegad pubchem gtoplig chembl_ligand gtoplig |
PAMAgonist | 3.5 | Intermediate | 10.1038/S41586-021-03495-2 | 2021-06-23 | |
7MT8 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (all-trans)
pubchem
|
Agonist | 5.8 | Active | 10.1038/S41586-021-03721-X | 2021-07-07 | |
7YXA | S1PR5 | S1P5 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
4-[6-(2-naphthalen-1...
pubchem
|
Antagonist | 2.2 | Inactive | 10.1038/S41467-022-32447-1 | 2022-08-10 | |
4UHR | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 4.8-4.8 | 22°C |
CGS 21680
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 2.6 | Active | 10.1124/mol.114.097360 | 2015-04-08 | |
7TRS | ACM4 | M4 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
acetylcholine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
|
Agonist | 2.8 | Active | 2023-05-17 | ||
7E33 | 5HT1E | 5-HT1E | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
BRL-54443
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.9 | Active | 10.1038/S41586-021-03376-8 | 2021-04-14 | |
8E9Z | ACM3 | M3 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
iperoxo
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.7 | Active | 10.1038/S41586-022-05489-0 | 2022-11-30 | |
8FLU | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PTH
|
Agonist | 2.8 | Active | 10.1016/J.STR.2023.04.002 | 2023-04-26 | |
6ORV | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3950796
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1038/s41586-019-1902-z | 2020-01-08 | |
7XAU | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Octreotide
|
Agonist | 3.0 | Active | 10.1038/S41421-022-00405-2 | 2022-08-31 | |
3UZC | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 6 chems | 8.0-8.0 | 4°C |
CHEMBL2024114
chembl_ligand
pubchem
|
Antagonist | 3.3 | Inactive | 10.1021/jm201376w | 2012-03-21 | ||
8IRV | DRD5 | D5 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
rotigotine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.1 | Active | 10.1038/S41422-023-00808-0 | 2023-06-07 | |
6XBL | SMO | SMO | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cholesterol
pubchem
SAG1.3 pubchem gtoplig chembl_ligand |
AgonistPAM | 3.9 | Active | 10.1038/S41589-020-0646-2 | 2020-09-30 | |
7F23 | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dopamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.6 | Active | 10.1126/SCIADV.ABO4158 | 2022-06-15 | |
5LWE | CCR9 | CCR9 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.9-8.0 | 20°C |
vercirnon
pubchem
gtoplig
chembl_ligand
drugbank
|
Allosteric antagonist | 2.8 | Inactive | 10.1038/NATURE20606 | 2016-12-07 | |
5DSG | ACM4 | M4 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.5-8.0 | 20°C |
tiotropium
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
chembl_ligand
chembl_ligand
|
Antagonist | 2.6 | Inactive | 10.1038/NATURE17188 | 2016-03-16 | |
6ME4 | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-iodo-melatonin
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.2 | Inactive | 10.1038/S41586-019-1141-3 | 2019-04-24 | |
6J20 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
aprepitant
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 2.7 | Inactive | 10.1038/S41467-019-08568-5 | 2019-03-06 | |
6QZH | CCR7 | CCR7 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SCHEMBL13407377
pubchem
|
Allosteric antagonist | 2.1 | Inactive | 10.1016/J.CELL.2019.07.028 | 2019-09-04 | |
4GRV | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C |
JMV431
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1038/NATURE11558 | 2012-10-17 | |
7M3F | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcium
pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem cinacalcet pubchem gtoplig chembl_ligand drugbank drug_central |
AgonistPAMPAM | 2.8 | Active | 10.1038/S41586-021-03691-0 | 2021-06-30 | |
7L1U | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Orexin-A
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41467-021-21087-6 | 2021-02-10 | |
4X1H | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 3 chems | 5.0-6.5 | 4°C |
B-Nonylglucoside
pubchem
|
unknown | 2.3 | Active | 10.1016/J.STR.2015.09.015 | 2015-11-04 | ||
6WJC | ACM1 | M1 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ENDO-ATROPINE
chembl_ligand
pubchem
muscarinic toxin 7 gtoplig |
AntagonistNAM | 2.6 | Inactive | 10.1126/SCIENCE.AAX2517 | 2020-07-08 | |
6VCB | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
glucagon-like peptid...
pubchem
gtoplig
chembl_ligand
gtoplig
pubchem
pubchem
CHEMBL5197819 chembl_ligand pubchem |
AgonistPAM | 3.3 | Active | 10.1038/S41589-020-0589-7 | 2020-07-22 | |
6DO1 | AGTR1 | AT1 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL404594
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 10.1016/J.CELL.2018.12.006 | 2019-01-30 | |
7SIL | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
tecalcet
pubchem
gtoplig
chembl_ligand
Cyclomethyltryptopha... pubchem |
AgonistAgonist | 2.7 | Active | 10.1073/PNAS.2115849118 | 2022-01-19 | |
8ID9 | FFAR4 | FFA4 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
EPA
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.0 | Active | 10.1126/SCIENCE.ADD6220 | 2023-03-15 | |
7WUJ | AGRG4 | ADGRG4 | ADGRG | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.3 | Active | 10.1038/S41586-022-04590-8 | 2022-04-27 | |
2Y01 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 6 chems | 9.0-9.0 | 4°C |
Dobutamine
pubchem
|
Agonist (partial) | 2.6 | Inactive | 10.1038/NATURE09746 | 2011-03-30 | ||
6AKX | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4238063
chembl_ligand
pubchem
|
Antagonist | 2.8 | Inactive | 10.1021/acs.jmedchem.8b01077 | 2018-10-24 | |
7W0L | APJ | apelin | Apelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(1R,2S)-N-[4-(2,6-di...
pubchem
|
Agonist | 3.6 | Active | 10.1038/S41594-022-00797-5 | 2022-07-27 | |
2I36 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 2 chemicals | 2 steps | vapour diffusion | sitting drops | 5 chems | 7.0-8.0 | 5°C |
Apo (no ligand)
|
Apo (no ligand) | 4.1 | Inactive | 10.1073/PNAS.0608022103 | 2006-10-17 | ||
7WZ4 | GPR88 | GPR88 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.0 | Active | 10.1038/S41467-022-30081-5 | 2022-10-26 | |
6IBL | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
arformoterol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.7 | Active | 10.1038/S41586-020-2419-1 | 2019-01-09 | |
4LDO | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | 7.7 MAG | 5 chems | 6.5-6.5 | 20°C |
(-)-adrenaline
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.2 | Active | 10.1038/NATURE12572 | 2013-09-25 | |
5YC8 | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-methyl scopolamine
pubchem
gtoplig
drugbank
gtoplig
chembl_ligand
chembl_ligand
|
Antagonist | 2.5 | Inactive | 10.1038/S41589-018-0152-Y | 2018-11-21 | |
6FFH | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-6.8 | 20°C |
fenobam
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
pubchem
pubchem
pubchem
|
NAM | 2.7 | Inactive | 10.1021/ACS.JMEDCHEM.7B01722 | 2018-03-07 | |
5WIV | DRD4 | D4 | Dopamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.9-6.2 | 20°C |
[3H]NEMONAPRIDE
chembl_ligand
pubchem
|
Antagonist | 2.1 | Inactive | 10.1126/SCIENCE.AAN5468 | 2017-10-18 | |
6VJM | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 4.0 | Inactive | 10.1038/S41586-020-2408-4 | 2020-06-10 | |
7TMW | RXFP1 | RXFP1 | Relaxin family peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
H2 relaxin
pubchem
|
Agonist | 3.2 | Active | 2023-02-15 | ||
7UL2 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
meclinertant
pubchem
gtoplig
chembl_ligand
drugbank
|
Inverse agonist | 2.4 | Inactive | 10.1038/S41594-022-00859-8 | 2022-06-29 | |
5T1A | CCR2 | CCR2 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 6.5-6.5 | 20 °C. |
CCR2-RA-[R]
pubchem
gtoplig
chembl_ligand
BMS-681 pubchem gtoplig chembl_ligand |
Allosteric antagonistAntagonist | 2.8 | Inactive | 10.1038/NATURE20605 | 2016-12-14 | |
6KO5 | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1956994
chembl_ligand
pubchem
|
Antagonist | 3.3 | Inactive | 10.1038/S41467-020-17554-1 | 2020-08-12 | |
7VDM | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 3.0 | Active | 10.1038/S41586-021-04077-Y | 2021-12-01 | |
3OE8 | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.0-6.0 | 20°C |
isothiourea-1t
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.1 | Inactive | 10.1126/SCIENCE.1194396 | 2010-10-27 | |
2YCW | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion |