Experiment Browser

Show/hide columns:



Loading...
RECEPTOR EXPRESSION SOLUBILIZATION PURIFICATION STRUCTURE DETERMINATION
PDB pH Temp Resolution Reference Date
7LCK GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A DANUGLIPRON chembl_ligand pubchem
Agonist 3.2 Active 2021-01-20
7M3G CASR CaS Calcium-sensing C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Calcium pubchem
evocalcet pubchem gtoplig drug_central chembl_ligand drugbank
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem
AgonistPAMPAM 2.5 Active 10.1038/S41586-021-03691-0 2021-06-30
6ZG4 ACM1 M1 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Ethyl (4S)-4-[4-[(1-... pubchem
Agonist 2.3 Inactive 10.1016/J.CELL.2021.11.001 2021-10-06
3RZE HRH1 H1 Histamine A (Rhodopsin) Human Pichia PastorisP. pastoris SMD1163Yeast 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 4.5-4.5 20-22°C doxepin pubchem gtoplig chembl_ligand drugbank gtoplig
Antagonist 3.1 Inactive 10.1038/NATURE10236 2011-06-15
7KI0 GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A semaglutide pubchem gtoplig chembl_ligand drugbank pubchem
Agonist 2.5 Active 10.1016/J.CELREP.2021.109374 2021-08-04
2Y00 ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 1 chemicals 1 steps vapour diffusionsitting drops 6 chems 8.5-8.5 4°C Dobutamine pubchem
Agonist (partial) 2.5 Inactive 10.1038/NATURE09746 2011-01-12
6RNK SUCR1 succinate Succinate A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A NF-56-EJ40 pubchem gtoplig chembl_ligand
Antagonist 1.9 Intermediate 10.1038/S41586-019-1663-8 2019-08-14
4MQT ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.2-7.9 20°C LY2119620 pubchem gtoplig chembl_ligand
iperoxo pubchem gtoplig chembl_ligand
PAMAgonist 3.7 Active 10.1038/NATURE12735 2013-11-27
7WVV FPR2 FPR2/ALX Formylpeptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A FME-LEU-PHE-ILE-ILE
Agonist 2.9 Active 10.1038/S41467-022-29361-X 2022-04-13
7EW2 S1PR3 S1P3 Lysophospholipid (S1P) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (S)-FTY720-phosphate pubchem gtoplig chembl_ligand
Agonist 3.1 Active 10.1038/S41422-021-00567-W 2021-09-29
7T6U FPR2 FPR2/ALX Formylpeptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A synthetic peptide
Agonist 2.9 Active 2022-03-30
7P2L GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A alloswitch-1 pubchem gtoplig
NAM 2.5 Inactive 10.1016/J.CELREP.2021.109648 2021-09-08
5WIU DRD4 D4 Dopamine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 5 chems 5.8-6.2 20°C [3H]NEMONAPRIDE chembl_ligand pubchem
Antagonist 2.0 Inactive 10.1126/SCIENCE.AAN5468 2017-10-18
6WZG SCTR secretin Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SECRETIN chembl_ligand pubchem
Agonist 2.3 Active 10.1038/S41467-020-17791-4 2020-08-12
5G53 AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps vapour diffusionSitting drop 6 chems 5.7-5.7 4°C NECA pubchem gtoplig chembl_ligand gtoplig
Agonist 3.4 Active 10.1038/NATURE18966 2016-08-03
6LML GLR glucagon Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A glucagon pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem pubchem pubchem pubchem
Agonist 3.9 Active 10.1126/SCIENCE.AAZ5346 2020-04-01
7EWL GP158 GPR158 C Orphans C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.5 Inactive 10.1038/S41467-021-27147-1 2021-12-01
2Y01 ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 1 chemicals 1 steps vapour diffusionsitting drops 6 chems 9.0-9.0 4°C Dobutamine pubchem
Agonist (partial) 2.6 Inactive 10.1038/NATURE09746 2011-03-30
6DRX 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A lisuride pubchem gtoplig chembl_ligand drugbank drug_central
Antagonist 3.1 Intermediate 10.1038/s41594-018-0116-7 2018-08-29
4X1H OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionsitting drop 3 chems 5.0-6.5 4°C B-Nonylglucoside pubchem
unknown 2.3 Active 10.1016/J.STR.2015.09.015 2015-11-04
4GRV NTR1 NTS1 Neurotensin A (Rhodopsin) Rat BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.0-7.0 20°C JMV431 gtoplig chembl_ligand pubchem
Agonist 2.8 Active 10.1038/NATURE11558 2012-10-17
6IQL DRD4 D4 Dopamine A (Rhodopsin) Mouse N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A L745870 pubchem gtoplig chembl_ligand
Antagonist 3.5 Inactive 10.7554/ELIFE.48822 2019-12-04
5K2C AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.0-5.0 20°C ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 1.9 Inactive 10.1126/SCIADV.1600292 2016-09-21
4DAJ ACM3 M3 Acetylcholine (muscarinic) A (Rhodopsin) Rat BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.5-7.5 22°C tiotropium pubchem gtoplig chembl_ligand drugbank gtoplig
Antagonist 3.4 Inactive 10.1038/NATURE10867 2012-02-22
7XT8 5HT4R 5-HT4 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5-hydroxytryptamine pubchem gtoplig chembl_ligand drugbank
Agonist 3.1 Active 10.1016/J.MOLCEL.2022.05.031 2022-07-27
5XRA CNR1 CB1 Cannabinoid A (Rhodopsin) Human Transient_transfectionHEK293TMammalian 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.4-6.4 20°C AM11542 pubchem gtoplig chembl_ligand
Agonist 2.8 Active 10.1038/NATURE23272 2017-07-12
4MBS CCR5 CCR5 Chemokine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.0-7.0 20°C maraviroc pubchem gtoplig drugbank chembl_ligand gtoplig
Antagonist 2.7 Inactive 10.1126/SCIENCE.1241475 2013-09-11
7S8P MRGX4 MRGPRX4 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N-[(1r,3R,5S,7R)-3,5... pubchem
Agonist 2.6 Active 10.1038/S41586-021-04126-6 2021-11-17
7WI6 GRM3 mGlu3 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A LY341495 pubchem gtoplig chembl_ligand gtoplig
Antagonist 3.7 Inactive 10.1038/S41422-022-00623-Z 2022-03-16
7EPA GRM2 mGlu2 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.6 Inactive 10.1038/S41586-021-03641-W 2021-06-23
7F2O BKRB2 B2 Bradykinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A bradykinin pubchem gtoplig chembl_ligand drugbank gtoplig
Agonist 2.9 Active 10.1038/S41594-021-00645-Y 2021-10-13
3AYN OPSD Rhodopsin Opsins A (Rhodopsin) Japanese flying squid NANativeSquid 1 chemicals 1 steps vapour diffusionsitting drop 5 chems 6.0-6.0 4°C Retinal (9-cis) pubchem
Inverse agonist 2.7 Inactive 10.1016/J.JMB.2011.08.044 2011-08-17
7V35 GLR glucagon Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Peptide-20
Agonist 3.4 Active 10.1038/S41467-022-28683-0 2022-03-02
4NTJ P2Y12 P2Y12 P2Y A (Rhodopsin) Human BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.0-6.5 20°C AZD1283 pubchem gtoplig chembl_ligand
Antagonist 2.6 Intermediate 10.1038/NATURE13083 2014-03-26
7M3J CASR CaS Calcium-sensing C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A NPS 2143 pubchem gtoplig chembl_ligand drugbank
NAM 4.1 Inactive 10.1038/S41586-021-03691-0 2021-06-30
6FKC OPSD Rhodopsin Opsins A (Rhodopsin) Bovine BaculovirusHEK293S(TetR)-GnTI-Mammalian 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 4.5-4.5 20°C 3-[1'-[(2~{S})-2-(4-... pubchem
Agonist 2.5 Active 10.1073/PNAS.1718084115 2018-04-04
6PGS OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Geraniol pubchem
unknown 2.9 Active 2020-07-01
5VRA AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 7 chems 4.6-5.0 20°C ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 2.4 Inactive 10.1038/NPROT.2017.135 2017-12-13
6TP3 OX1R OX1 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A daridorexant pubchem gtoplig chembl_ligand drugbank
Antagonist 3.0 Inactive 10.1021/acs.jmedchem.9b01787 2020-01-01
6OMM FPR2 FPR2/ALX Formylpeptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL552527 chembl_ligand pubchem
Agonist 3.2 Active 10.1038/S41467-020-14728-9 2020-02-26
7EWR GP158 GPR158 C Orphans C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 4.7 Inactive 10.1038/S41467-021-27147-1 2021-12-01
5W0P OPSD Rhodopsin Opsins A (Rhodopsin) Human Transient_transfectionHEK293S(TetR- GnTI-Mammalian 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monopalmitolein (9.7 MAG) 5 chems 5.0-5.0 20°C Apo (no ligand)
Apo (no ligand) 3.0 Active 10.1016/J.CELL.2017.07.002 2017-08-09
4UG2 AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusHi5Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 3 chems 7.0-7.0 22°C CGS 21680 pubchem gtoplig chembl_ligand gtoplig
Agonist 2.6 Active 10.1124/mol.114.097360 2015-04-08
6UO9 GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL112710 chembl_ligand pubchem pubchem
Agonist 4.8 Inactive 10.1038/S41586-020-2408-4 2020-06-10
7RTB GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Peptide-19
Agonist 2.1 Active 10.1016/J.BBRC.2021.09.016 2021-10-06
4IAQ 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 8.7-8.7 20°C dihydroergotamine pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 2.8 Inactive 10.1126/SCIENCE.1232807 2013-03-13
5JQH ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)7.7 MAG 5 chems 7.5-7.5 23°C Carazolol pubchem
Inverse agonist 3.2 Inactive 10.1038/NATURE18636 2016-07-13
5UEN AA1R A1 Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.0-8.0 20°C DU172 pubchem gtoplig chembl_ligand
Antagonist 3.2 Inactive 10.1016/j.cell.2017.01.042 2017-03-01
6Z8N NTR1 NTS1 Neurotensin A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (2~{S})-4-methyl-2-[... pubchem
Agonist 2.8 Intermediate 10.1126/sciadv.abe5504 2021-02-10
6LI0 GPR52 GPR52 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A derivative 17 [Nakah... pubchem gtoplig chembl_ligand
Agonist 2.2 Inactive 10.1038/S41586-020-2019-0 2020-02-26
6TQ9 OX1R OX1 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SB-408124 pubchem gtoplig chembl_ligand
Antagonist 2.7 Inactive 10.1021/acs.jmedchem.9b01787 2020-01-01
7DTY GIPR GIP Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GIP pubchem pubchem
Agonist 3.0 Active 10.7554/ELIFE.68719 2021-08-04
4BEZ OPSD Rhodopsin Opsins A (Rhodopsin) Bovine Stable_cellsHEK293S-GnTI-Mammalian 1 chemicals 1 steps vapour diffusionsitting drop 4 chems 4.5-4.5 20°C Apo (no ligand)
Apo (no ligand) 3.3 Active 10.1038/EMBOR.2013.44 2013-04-24
7F4H MSHR MC1 Melanocortin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL407070 chembl_ligand pubchem pubchem
Agonist 2.7 Active 10.1038/S41422-021-00557-Y 2021-09-08
7E32 5HT1D 5-HT1D 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5-hydroxytryptamine pubchem gtoplig chembl_ligand drugbank
Agonist 2.9 Active 10.1038/S41586-021-03376-8 2021-04-21
7JVP DRD1 D1 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 39YLC3L0ZU pubchem
Agonist 2.9 Active 10.1016/J.CELL.2021.01.027 2021-02-24
6RZ7 CLTR2 CysLT2 Leukotriene A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ONO-2570366 gtoplig pubchem
Antagonist 2.4 Intermediate 10.1038/S41467-019-13348-2 2019-12-11
6Z10 SUCR1 succinate Succinate A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL4751488 chembl_ligand pubchem
Antagonist 2.3 Intermediate 10.1021/acs.jmedchem.0c01020 2020-09-16
7WU5 AGRF1 ADGRF1 ADGRF B2 (Adhesion) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.0 Active 10.1038/S41586-022-04580-W 2022-04-27
7P00 NK1R NK1 Tachykinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A substance P pubchem gtoplig chembl_ligand gtoplig gtoplig
Agonist 2.7 Active 10.1126/SCIADV.ABK2872 2021-12-15
6I9K B1B1U5 Rhodopsin Opsins A (Rhodopsin) Hasarius adansoni N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Retinal (11-cis) pubchem
Inverse agonist 2.2 Inactive 10.1073/PNAS.1902192116 2019-07-03
6ZDV AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2-Methyl-3-(4-methyl... pubchem
Antagonist 2.1 Inactive 10.1002/ANIE.202003788 2020-09-16
6PWC NTR1 NTS1 Neurotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Neurotensin pubchem
Agonist 4.9 Active 10.1038/S41422-019-0256-2 2019-12-04
7F9Z GHSR ghrelin Ghrelin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GHRP-6 pubchem gtoplig
Agonist 3.2 Active 2021-08-18
5X33 Q9WTK1 BLT1 Leukotriene A (Rhodopsin) Guinea pig Pichia PastorisP. pastoris SMD1163Yeast 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 7 chems 8.5-9.0 4°C BIIL 260 pubchem gtoplig
Antagonist 3.7 Inactive 10.1038/NCHEMBIO.2547 2018-01-03
6M1I PACR PAC1 VIP and PACAP B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL524658 chembl_ligand pubchem
Agonist 3.5 Active 10.1038/S41422-020-0280-2 2020-03-11
7D76 AGRG3 ADGRG3 ADGRG B2 (Adhesion) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Beclomethasone pubchem
Agonist 3.1 Active 10.1038/S41586-020-03083-W 2021-02-03
6Z4Q NTR1 NTS1 Neurotensin A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SR142948A pubchem gtoplig chembl_ligand
Inverse agonist 2.9 Inactive 10.1126/sciadv.abe5504 2021-02-10
6KJV GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PF-06372222 pubchem
NAM 2.8 Inactive 10.1107/S2052252519013496 2019-11-13
6IIU TA2R TP Prostanoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ramatroban pubchem gtoplig chembl_ligand drug_central drugbank gtoplig
Antagonist 2.5 Intermediate 10.1038/S41589-018-0170-9 2018-12-19
5TUD 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human BaculovirusSf21Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monopalmitolein (9.7 MAG) 6 chems 7.7-7.7 20°C ergotamine pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.0 Active 10.1073/PNAS.1700891114 2017-07-26
2I36 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 2 chemicals 2 steps vapour diffusionsitting drops 5 chems 7.0-8.0 5°C Apo (no ligand)
Apo (no ligand) 4.1 Inactive 10.1073/PNAS.0608022103 2006-10-17
5DSG ACM4 M4 Acetylcholine (muscarinic) A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.5-8.0 20°C tiotropium pubchem gtoplig chembl_ligand drugbank gtoplig
Antagonist 2.6 Inactive 10.1038/NATURE17188 2016-03-16
3C9M OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANANA 1 chemicals 1 steps NANANA 1 chems 0.0-0.0 NA Retinal (11-cis) pubchem
Inverse agonist 3.4 Inactive 10.1107/S0907444908017162 2008-08-05
6Z66 NTR1 NTS1 Neurotensin A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.2 Intermediate 10.1126/sciadv.abe5504 2021-02-10
6UO8 GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GS39783 pubchem gtoplig chembl_ligand
CHEMBL112710 chembl_ligand pubchem pubchem
PAMAgonist 3.6 Active 10.1038/S41586-020-2408-4 2020-06-10
7EJ0 ADA2A α2A Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (-)-noradrenaline pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.2 Active 2022-04-13
1F88 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 2 chemicals 2 steps vapour diffusionHanging drop 7 chems 6.0-6.0 4°C Retinal (11-cis) pubchem
Inverse agonist 2.8 Inactive 10.1126/SCIENCE.289.5480.739 2000-08-04
6IBL ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A arformoterol pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 2.7 Active 10.1101/436212 2019-01-09
7MTB OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Retinal (all-trans) pubchem
Agonist 4.0 Active 10.1038/S41586-021-03721-X 2021-07-07
5OLV AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20°C CHEMBL1671936 chembl_ligand pubchem
Antagonist 2.0 Inactive 10.1038/S41598-017-18570-W 2018-01-17
6NBH PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Long-acting parathyr...
Agonist 3.5 Active 10.1126/SCIENCE.AAV7942 2019-04-17
6E3Y CALRL calcitonin-like Calcitonin B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Calcitonin gene-rela... pubchem
Agonist 3.3 Active 10.1038/S41586-018-0535-Y 2018-09-19
3OE6 CXCR4 CXCR4 Chemokine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.5-5.5 20°C isothiourea-1t pubchem gtoplig chembl_ligand
Antagonist 3.2 Inactive 10.1126/SCIENCE.1194396 2010-10-27
7VLA CCR1 CCR1 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CCL15(27-92)
Agonist 2.7 Active 10.1038/S41589-021-00918-Z 2022-03-23
6IBB SUCR1 succinate Succinate A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.1 Intermediate 10.1038/S41586-019-1663-8 2019-08-14
6TQ6 OX1R OX1 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL4592653 chembl_ligand pubchem
Antagonist 2.6 Inactive 10.1021/acs.jmedchem.9b01787 2020-01-01
6VJM GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 4.0 Inactive 10.1038/S41586-020-2408-4 2020-06-10
6ZFZ ACM1 M1 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL3354065 chembl_ligand pubchem
Agonist 2.2 Inactive 10.1016/J.CELL.2021.11.001 2021-10-06
7VUZ MRGX2 MRGPRX2 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PAMP-12 pubchem
Agonist 2.9 Active 2021-12-01
7T6V FPR2 FPR2/ALX Formylpeptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A synthetic peptide
Agonist 3.1 Active 2022-03-30
7EIB BKRB1 B1 Bradykinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A [des-Arg<sup>10</sup... pubchem gtoplig chembl_ligand gtoplig
Agonist 3.0 Active 10.1038/S41594-021-00645-Y 2021-10-13
7VUI GP139 GPR139 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A JNJ-63533054 pubchem gtoplig chembl_ligand
Agonist 3.3 Active 10.1038/S41422-021-00591-W 2021-12-29
7XTC 5HT7R 5-HT7 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5-CT pubchem gtoplig chembl_ligand
Agonist 3.2 Active 10.1016/J.MOLCEL.2022.05.031 2022-07-27
7MT8 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Retinal (all-trans) pubchem
Agonist 5.8 Active 10.1038/S41586-021-03721-X 2021-07-07
7E33 5HT1E 5-HT1E 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A BRL-54443 pubchem gtoplig chembl_ligand
Agonist 2.9 Active 10.1038/S41586-021-03376-8 2021-04-14
7MTR GRM2 mGlu2 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A L-glutamic acid pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem
2-methoxy-6-propyl-N... pubchem
AgonistAgo-PAM 3.3 Active 10.1038/S41586-021-03680-3 2021-07-07
7DD5 CASR CaS Calcium-sensing C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Calcium pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem
NPS 2143 pubchem gtoplig chembl_ligand drugbank
AgonistPAMNAM 3.2 Inactive 10.1126/SCIADV.ABG1483 2021-06-16
6N48 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2-[[(3R)-4-(4-Tert-b... pubchem
BI-167107 pubchem
PAMAgonist 3.2 Active 10.1126/SCIENCE.AAW8981 2019-06-26
5OLG AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20°C ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 1.9 Inactive 10.1038/S41598-017-18570-W 2018-01-17
5UNG AGTR2 AT2 Angiotensin A (Rhodopsin) Human BaculovirusSf21Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 7 chems 8.0-8.0 20°C compound 1 [PMID: 28... pubchem gtoplig chembl_ligand
Antagonist 2.8 Active 10.1038/NATURE22035 2017-04-05
7CX2 PE2R2 EP2 Prostanoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PGE2 pubchem gtoplig chembl_ligand drugbank drug_central gtoplig
Agonist 2.8 Active 10.1126/SCIADV.ABF1268 2021-05-05
7EZK CCKAR CCK1 Cholecystokinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CCK-8 pubchem gtoplig chembl_ligand drug_central drugbank
Agonist 3.1 Active 2021-08-25
2YDV AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusHi5Insect 4 chemicals 4 steps vapour diffusionsitting drop 5 chems 6.4-6.4 4°C NECA pubchem gtoplig chembl_ligand gtoplig
Agonist 2.6 Active 10.1038/NATURE10136 2011-05-18
6X1A GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A DANUGLIPRON chembl_ligand pubchem
Agonist 2.5 Active 10.1101/2020.08.16.252585 2020-09-09
7DW9 V2R V2 Vasopressin and oxytocin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A vasopressin pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 2.6 Active 10.1038/S41422-021-00480-2 2021-07-21
6N4B CNR1 CB1 Cannabinoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A MDMB-Fubinaca pubchem gtoplig
Agonist 3.0 Active 10.1016/J.CELL.2018.11.040 2019-01-30
6PS1 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A timolol pubchem gtoplig chembl_ligand drugbank drug_central
Antagonist 3.2 Inactive 10.1107/S2052252519013137 2019-11-13
6ME9 MTR1B MT2 Melatonin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ramelteon pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.3 Inactive 10.1038/S41586-019-1144-0 2019-04-24
6JOD AGTR2 AT2 Angiotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A angiotensin II pubchem gtoplig chembl_ligand drug_central drugbank pubchem
Agonist 3.2 Active 10.1016/J.STR.2019.12.003 2020-01-15
6OY9 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Retinal (all-trans) pubchem
Agonist 3.9 Active 10.1016/J.MOLCEL.2019.06.007 2019-07-24
2I37 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 2 chemicals 2 steps vapour diffusionsitting drops 5 chems 7.0-8.0 5°C Apo (no ligand)
Apo (no ligand) 4.2 Inactive 10.1073/PNAS.0608022103 2006-10-17
5OLZ AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20°C CHEMBL2024114 chembl_ligand pubchem
Antagonist 1.9 Inactive 10.1038/S41598-017-18570-W 2018-01-17
7F9Y GHSR ghrelin Ghrelin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ghrelin gtoplig
Agonist 2.9 Active 2021-08-18
2YCZ ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 2 chemicals 2 steps vapour diffusionNA 3 chems 6.9-7.3 NA Iodocyanopindolol pubchem
Antagonist 3.7 Inactive 10.1073/PNAS.1100185108 2011-06-01
7S3I GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A exendin-4 pubchem gtoplig pubchem
Agonist 2.5 Active 10.1038/S41589-021-00945-W 2022-01-05
3ZEV NTR1 NTS1 Neurotensin A (Rhodopsin) Rat NAE. coli BL21(DE3)Bacteria 3 chemicals 3 steps vapour diffusionsitting drops 7 chems 9.4-9.4 4°C neurotensin pubchem gtoplig chembl_ligand gtoplig gtoplig
Agonist 3.0 Inactive 10.1073/PNAS.1317903111 2014-01-29
7VGY MTR1A MT1 Melatonin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2-iodo-melatonin pubchem gtoplig chembl_ligand drugbank
Agonist 3.1 Active 2022-03-02
5OM1 AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20°C CHEMBL2024114 chembl_ligand pubchem
Antagonist 2.1 Inactive 10.1038/S41598-017-18570-W 2018-01-17
7RYC OXYR OT Vasopressin and oxytocin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A oxytocin pubchem gtoplig chembl_ligand drugbank drug_central gtoplig
Agonist 2.9 Active 10.1038/S41594-022-00728-4 2022-03-09
4LDE ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)7.7 MAG 5 chems 6.5-6.5 20°C BI-167107 pubchem
Agonist 2.8 Active 10.1038/NATURE12572 2013-09-25
5NJ6 PAR2 PAR2 Proteinase-activated A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 7 chems 5.5-6.2 20°C N/A N/A 4.0 Intermediate 10.1038/NATURE22309 2017-05-03
6LRY EDNRB ETB Endothelin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A sarafotoxin S6b pubchem gtoplig chembl_ligand chembl_ligand pubchem
Agonist 3.0 Inactive 10.1016/J.BBRC.2019.12.091 2020-02-12
7T6T FPR1 FPR1 Formylpeptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A synthetic peptide
Agonist 3.2 Active 2022-03-30
5VBL APJ apelin Apelin A (Rhodopsin) Human BaculovirusSf21Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 7 chems 6.1-6.1 20-22°C AMG3054 gtoplig
Agonist 2.6 Inactive 10.1016/J.STR.2017.04.008 2017-05-31
3OE0 CXCR4 CXCR4 Chemokine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.0-6.0 20°C CVX15
Antagonist 2.9 Inactive 10.1126/SCIENCE.1194396 2010-10-27
3ODU CXCR4 CXCR4 Chemokine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.5-5.5 20°C isothiourea-1t pubchem gtoplig chembl_ligand
Antagonist 2.5 Inactive 10.1126/SCIENCE.1194396 2010-10-27
7WQ3 GALR1 GAL1 Galanin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A galanin gtoplig chembl_ligand gtoplig pubchem pubchem pubchem pubchem pubchem
Agonist 2.7 Active 2022-04-20
7SHE GP158 GPR158 C Orphans C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.4 Inactive 10.1126/SCIENCE.ABL4732 2021-12-01
4RWA OPRD δ Opioid A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 6.0-6.0 20°C DIPP-NH2
Antagonist 3.3 Inactive 10.1038/NSMB.2965 2015-01-14
3DQB OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionhanging drops 5 chems 5.9-6.1 10°C Apo (no ligand)
Apo (no ligand) 3.2 Active 10.1038/NATURE07330 2008-09-23
7WVX FPR2 FPR2/ALX Formylpeptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A humanin pubchem gtoplig chembl_ligand pubchem
Agonist 2.8 Active 10.1038/S41467-022-29361-X 2022-04-13
6UUS CALRL calcitonin-like Calcitonin B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Adrenomedullin pubchem
Agonist 2.4 Active 10.1021/ACSPTSCI.9B00080 2020-04-01
7RGP GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A tirzepatide pubchem gtoplig
Agonist 2.9 Active 10.1073/PNAS.2116506119 2022-04-13
6NWE OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A B-Octylglucoside pubchem
unknown 2.7 Active 2020-02-12
5V54 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 7 chems 7.0-7.0 20°C CHEMBL428892 chembl_ligand pubchem
Antagonist 3.9 Inactive 2018-02-07
7LLY GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Pro-glucagon pubchem
Agonist 3.3 Active 10.1038/S41467-021-27760-0 2022-01-12
7RMI NK1R NK1 Tachykinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A substance P pubchem gtoplig chembl_ligand gtoplig gtoplig
Agonist 3.2 Active 10.1038/S41589-021-00890-8 2021-11-03
5D6L ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.0-7.0 20°C Carazolol pubchem
Inverse agonist 3.2 Inactive 10.1038/NPROT.2017.057 2016-08-17
6CM4 DRD2 D2 Dopamine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 6 chems 7.8-7.8 20°C risperidone pubchem gtoplig chembl_ligand drugbank drug_central
Inverse agonist 2.9 Inactive 10.1038/NATURE25758 2018-03-14
4QKX ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)7.7 MAG 5 chems 7.8-8.4 20°C Q27453560 pubchem
Agonist 3.3 Active 10.1073/PNAS.1410415111 2014-07-23
7EPD GRM2 mGlu2 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.9 Inactive 10.1038/S41586-021-03641-W 2021-06-23
6LN2 GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PF-06372222 pubchem
NAM 3.2 Inactive 10.1038/S41467-020-14934-5 2020-03-18
7RKN US28 US28 Unclassified A (Rhodopsin) strain AD169 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Fractalkine pubchem
Agonist 3.6 Active 10.1126/SCIADV.ABL5442 2022-01-26
7VDH MRGX2 MRGPRX2 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A compound 48/80 pubchem gtoplig
Agonist 2.9 Active 2021-12-01
7DD7 CASR CaS Calcium-sensing C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Calcium pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem
evocalcet pubchem gtoplig drug_central chembl_ligand drugbank
AgonistPAMPAM 3.2 Active 10.1126/SCIADV.ABG1483 2021-06-16
6BQH 5HT2C 5-HT2C 5-Hydroxytryptamine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 5 chems 6.0-6.0 20°C ritanserin pubchem gtoplig chembl_ligand drugbank
Inverse agonist 2.7 Inactive 10.1016/j.cell.2018.01.001 2018-02-14
6OYA OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Retinal (all-trans) pubchem
Agonist 3.3 Active 10.1016/J.MOLCEL.2019.06.007 2019-07-24
5CGD GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human BaculovirusSf21Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 5.5-6.8 20°C CHEMBL3603923 chembl_ligand pubchem
NAM 2.6 Inactive 10.1021/acs.jmedchem.5b00892 2015-08-12
3ZPQ ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 1 chemicals 1 steps vapour diffusionsitting drops 3 chems 9.0-9.0 4°C CHEMBL200234 chembl_ligand pubchem
Antagonist 2.8 Inactive 10.1021/jm400140q 2013-04-03
6HLP NK1R NK1 Tachykinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A netupitant pubchem gtoplig chembl_ligand drug_central drugbank
Antagonist 2.2 Inactive 10.1038/S41467-018-07939-8 2019-01-16
7WUJ AGRG4 ADGRG4 ADGRG B2 (Adhesion) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.3 Active 10.1038/S41586-022-04590-8 2022-04-27
4OO9 GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human BaculovirusSf21Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 6.8-6.8 20°C MAVOGLURANT chembl_ligand pubchem
NAM 2.6 Inactive 10.1038/NATURE13396 2014-07-02
7VDM MRGX2 MRGPRX2 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A substance P pubchem gtoplig chembl_ligand gtoplig gtoplig
Agonist 3.0 Active 2021-12-01
5TZR FFAR1 FFA1 Free fatty acid A (Rhodopsin) Human BaculovirusSf21Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.7-8.3 20°C MK-8666 pubchem
Agonist 2.2 Intermediate 10.1038/NSMB.3417 2017-06-07
4ZWJ OPSD Rhodopsin Opsins A (Rhodopsin) Human Transient_transfectionHEK293S(TetR)-GnTI-Mammalian 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monopalmitolein (9.7 MAG) 5 chems 5.0-5.0 20°C Apo (no ligand)
Apo (no ligand) 3.3 Active 10.1038/NATURE14656 2015-07-29
6TQ7 OX1R OX1 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SB-334867 pubchem gtoplig chembl_ligand
Antagonist 2.7 Inactive 10.1021/acs.jmedchem.9b01787 2020-01-01
7CRH DRD1 D1 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL1416789 chembl_ligand pubchem
Agonist 3.3 Active 10.1016/J.CELL.2021.01.028 2021-03-03
6KO5 GHSR ghrelin Ghrelin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL1956994 chembl_ligand pubchem
Antagonist 3.3 Inactive 2020-08-12
7EJK ADA2A α2A Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A oxymetazoline pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.4 Active 2022-04-13
6DDE OPRM μ Opioid A (Rhodopsin) Mouse BaculovirusSf9Insect 4 chemicals 4 steps Cryo-EMGatan K2 Summit direct electron camera , 300kV 5 chems 7.5-7.5 4°C DAMGO pubchem gtoplig chembl_ligand chembl_ligand
Agonist 3.5 Active 10.1038/S41586-018-0219-7 2018-06-13
7WVY FPR2 FPR2/ALX Formylpeptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Amyloid beta-Peptide... pubchem
Agonist 3.0 Active 10.1038/S41467-022-29361-X 2022-04-13
7WIH GRM3 mGlu3 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL4081453 chembl_ligand pubchem
Agonist 3.7 Inactive 10.1038/S41422-022-00623-Z 2022-03-16
5N2R AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20 PSB36 pubchem
Antagonist 2.8 Inactive 10.1016/j.str.2017.06.012 2017-07-26
6LI2 GPR52 GPR52 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 2.8 Inactive 10.1038/S41586-020-2019-0 2020-02-26
5IUA AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20 2-(Furan-2-yl)-5-N-[... pubchem
Antagonist 2.2 Inactive 10.1021/acs.jmedchem.6b00653 2016-06-29
7CMU DRD3 D3 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A pramipexole pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.0 Active 10.1016/J.MOLCEL.2021.01.003 2021-03-10
7RG9 GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.2 Active 10.1073/PNAS.2116506119 2022-04-13
6FFH GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human BaculovirusSf21Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 5.5-6.8 20°C fenobam pubchem gtoplig chembl_ligand drugbank gtoplig pubchem pubchem pubchem
NAM 2.7 Inactive 10.1021/ACS.JMEDCHEM.7B01722 2018-03-07
4J4Q OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionHanging drop 3 chems 5.2-6.0 4°C B-Octylglucoside pubchem
unknown 2.7 Active 10.1002/ANIE.201302374 2013-10-30
7TUZ GP183 GPR183 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (2S,4aS,4bS,7R,8S,8a... pubchem
Agonist 3.1 Active 10.1016/J.STR.2022.04.006 2022-04-13
4ZJ8 OX1R OX1 Orexin A (Rhodopsin) Human BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.4-5.4 20°C suvorexant pubchem gtoplig chembl_ligand drug_central drugbank
Antagonist 2.8 Inactive 10.1038/NSMB.3183 2016-03-09
6WI9 SCTR secretin Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SECRETIN chembl_ligand pubchem
Agonist 4.3 Active 10.1038/S41467-020-17791-4 2020-08-12
6PT0 CNR2 CB2 Cannabinoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A WIN55212-2 pubchem gtoplig chembl_ligand drugbank
Agonist 3.2 Active 10.1016/J.CELL.2020.01.007 2020-02-12
6LW5 FPR2 FPR2/ALX Formylpeptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL552527 chembl_ligand pubchem
Agonist 2.8 Active 10.1038/S41467-020-15009-1 2020-03-25
5GLH EDNRB ETB Endothelin A (Rhodopsin) Human BaculovirusSF+Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 6.0-6.0 20°C ENDOTHELIN chembl_ligand pubchem
Agonist 2.8 Inactive 10.1038/nature19319 2016-09-07
6FKD OPSD Rhodopsin Opsins A (Rhodopsin) Bovine BaculovirusHEK293S(TetR)-GnTI-Mammalian 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 4.5-4.5 20°C 5-chloro-2-(2-oxo-2-... pubchem
Agonist 2.5 Active 10.1073/PNAS.1718084115 2018-04-04
7V9M GHRHR GHRH Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Somatoliberin pubchem
Agonist 3.3 Active 2021-10-20
2Z73 OPSD Rhodopsin Opsins A (Rhodopsin) Japanese flying squid NANativeSquid 1 chemicals 1 steps vapour diffusionsitting drops 5 chems 6.4-6.4 4°C Retinal (11-cis) pubchem
Inverse agonist 2.5 Inactive 10.1038/NATURE06925 2008-05-13
6KNM APJ apelin Apelin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Single domain antibo...
Agonist 3.2 Inactive 10.1126/SCIADV.AAX7379 2020-01-29
6KK1 GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PF-06372222 pubchem
NAM 2.8 Inactive 10.1107/S2052252519013496 2019-11-13
7VV0 MRGX2 MRGPRX2 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PAMP-12 pubchem
Agonist 3.5 Active 2021-12-01
7S8M MRGX2 MRGPRX2 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Cortistatin 14 pubchem
Agonist 2.5 Active 10.1038/S41586-021-04126-6 2021-11-17
5V57 SMO SMO Frizzled F (Frizzled) Human Transient_transfectionHEK293FMammalian 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.0-5.0 20°C N-methyl-N-[1-[4-(2-... pubchem
Antagonist 3.0 Inactive 10.1038/NCOMMS15383 2017-05-24
5UVI AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.0-5.0 20°C ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 3.2 Inactive 10.1107/S205225251700570X 2017-05-24
7SIL CASR CaS Calcium-sensing C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Cyclomethyltryptopha... pubchem
tecalcet pubchem gtoplig chembl_ligand
AgonistAgonist 2.7 Active 10.1073/PNAS.2115849118 2022-01-19
7BW0 GPBAR GPBA Bile acid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.9 Active 10.1038/S41392-020-00262-Z 2020-09-02
3D4S ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.0-7.0 20°C timolol pubchem gtoplig chembl_ligand drugbank drug_central
Inverse agonist 2.8 Inactive 10.1016/J.STR.2008.05.001 2008-06-17
6GT3 AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A imaradenant pubchem gtoplig chembl_ligand drugbank
Antagonist 2.0 Inactive 2019-06-26
7DTT CASR CaS Calcium-sensing C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Calcium pubchem
Agonist 3.8 Inactive 10.1038/S41422-021-00474-0 2021-03-10
7DH5 ADRB3 β3 Adrenoceptors A (Rhodopsin) Dog N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A mirabegron pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.2 Active 10.1016/J.MOLCEL.2021.06.024 2021-08-04
3C9L OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANANA 1 chemicals 1 steps NANANA 1 chems 0.0-0.0 NA Retinal (11-cis) pubchem
Inverse agonist 2.7 Inactive 10.1107/S0907444908017162 2008-08-05
6PT3 OPRD δ Opioid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A DPI-287 pubchem
Agonist 3.3 Active 10.1126/SCIADV.AAX9115 2019-12-11
3PWH AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps vapour diffusionsitting drop 6 chems 8.0-8.8 4°C ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 3.3 Inactive 10.1016/J.STR.2011.06.014 2011-09-07
6AKY CCR5 CCR5 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CCR5 antagonist 34 pubchem gtoplig chembl_ligand
Antagonist 2.8 Inactive 10.1021/acs.jmedchem.8b01077 2018-10-24
6H7O ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (S)-Cyanopindolol pubchem
Agonist 2.8 Active 10.1126/SCIENCE.AAU5595 2018-10-17
5DHG OPRX NOP Opioid A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.4-6.4 20°C CHEMBL1783826 chembl_ligand pubchem
Antagonist 3.0 Inactive 10.1016/J.STR.2015.07.024 2015-10-21
5LWE CCR9 CCR9 Chemokine A (Rhodopsin) Human BaculovirusSf21Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.9-8.0 20°C vercirnon pubchem gtoplig chembl_ligand drugbank
Allosteric antagonist 2.8 Inactive 10.1038/NATURE20606 2016-12-07
6FK6 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine BaculovirusHEK293S(TetR)-GnTI-Mammalian 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 4.5-4.5 20°C COMPOUND SUMMARY pubchem
Agonist 2.4 Active 10.1073/PNAS.1718084115 2018-04-04
5EN0 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine Stable_cellsHEK293S(TetR)GnTI-Mammalian 1 chemicals 1 steps vapour diffusionSitting drop 4 chems 5.0-5.0 4°C Retinal (all-trans) pubchem
Agonist 2.8 Active 10.15252/EMBR.201642671 2016-08-10
6K41 ADA2B α2B Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A dexmedetomidine pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 2.9 Active 10.1038/S41589-020-0492-2 2020-04-15
7SBF OPRM μ Opioid A (Rhodopsin) Mouse N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N-[(2S)-2-(dimethyla... pubchem
Agonist 2.9 Active 10.1002/ANIE.202200269 2022-04-20
6VI4 OPRK κ Opioid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A JDTic pubchem gtoplig chembl_ligand
Antagonist 3.3 Inactive 10.1038/S41467-020-14889-7 2020-03-18
6LFO CXCR2 CXCR2 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Interleukin-8 pubchem
Agonist 3.4 Active 10.1038/S41586-020-2492-5 2020-09-02
7WC4 5HT2A 5-HT2A 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5-hydroxytryptamine pubchem gtoplig chembl_ligand drugbank
Agonist 3.2 Inactive 10.1126/SCIENCE.ABL8615 2022-01-26
3UON ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.5-7.5 19.85°C CHEMBL558910 chembl_ligand pubchem
Antagonist 3.0 Inactive 10.1038/NATURE10753 2012-02-01
6E67 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A BI-167107 pubchem
Agonist 3.7 Active 10.1016/J.CELL.2019.04.021 2019-06-05
7PIU MC4R MC4 Melanocortin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A setmelanotide pubchem gtoplig drug_central chembl_ligand drugbank
Agonist 2.6 Active 10.1038/S41422-021-00569-8 2021-11-17
4PHU FFAR1 FFA1 Free fatty acid A (Rhodopsin) Human BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.6-7.6 20°C fasiglifam pubchem gtoplig chembl_ligand drugbank
Agonist 2.3 Intermediate 10.1038/NATURE13494 2014-07-16
5XJM AGTR2 AT2 Angiotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL404594 chembl_ligand pubchem
Agonist 3.2 Active 10.1038/S41594-018-0079-8 2018-07-11
7F54 MC4R MC4 Melanocortin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A afamelanotide pubchem gtoplig chembl_ligand drugbank pubchem pubchem pubchem pubchem
Agonist 3.0 Active 10.1038/S41422-021-00552-3 2021-11-03
7VOD 5HT2A 5-HT2A 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A cariprazine pubchem gtoplig chembl_ligand drug_central drugbank
Agonist (partial) 3.3 Inactive 10.1038/S41593-021-00971-W 2021-12-22
7TYF CALCR CT Calcitonin B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A amylin peptide
Agonist 2.2 Active 10.1126/SCIENCE.ABM9609 2022-03-23
2HPY OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 5.9-6.1 283 K Retinal (all-trans) pubchem
Agonist 2.8 Inactive 10.1073/PNAS.0601765103 2006-08-22
6TPJ OX2R OX2 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A suvorexant pubchem gtoplig chembl_ligand drug_central drugbank
Antagonist 2.7 Inactive 10.1021/acs.jmedchem.9b01787 2020-01-01
6N51 GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A quisqualate pubchem gtoplig chembl_ligand drugbank gtoplig pubchem
Agonist 4.0 Intermediate 10.1038/S41586-019-0881-4 2019-01-23
7VKT LT4R1 BLT1 Leukotriene A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A LTB4 pubchem gtoplig chembl_ligand drugbank
Agonist 2.9 Active 10.1038/S41467-022-28820-9 2022-03-09
4XT1 US28 US28 Unclassified A (Rhodopsin) strain AD169 BaculovirusHEK293S(TetR)-GnTI-Mammalian 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 7 chems 6.3-7.0 20°C CX3CL1 gtoplig
Agonist (partial) 2.9 Active 10.1126/SCIENCE.AAA5026 2015-03-04
7JVR DRD2 D2 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A bromocriptine pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 2.8 Active 10.1016/J.CELL.2021.01.027 2021-02-24
4Z35 LPAR1 LPA1 Lysophospholipid (LPA) A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.5-5.5 20°C ONO-9910539 pubchem gtoplig
Antagonist 2.9 Inactive 10.1016/J.CELL.2015.06.002 2015-06-03
6U1N ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A LY2119620 pubchem gtoplig chembl_ligand
Agonist 4.0 Active 10.1038/S41586-020-1954-0 2020-02-26
4OR2 GRM1 mGlu1 Metabotropic glutamate C (Glutamate) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.0-7.0 20°C FITM pubchem gtoplig chembl_ligand
NAM 2.8 Inactive 10.1126/science.1249489 2014-03-19
7MT9 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Retinal (all-trans) pubchem
Agonist 7.0 Active 10.1038/S41586-021-03721-X 2021-07-07
7WC7 5HT2A 5-HT2A 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A lisuride pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 2.6 Inactive 10.1126/SCIENCE.ABL8615 2022-01-26
7CUM GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Unknown ligand
CGP 54626A pubchem gtoplig chembl_ligand gtoplig
NAMAntagonist 3.5 Inactive 10.1016/J.JMB.2020.09.023 2020-11-11
4RWS CXCR4 CXCR4 Chemokine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.5-5.5 20°C viral macrophage inf... pubchem gtoplig
Antagonist 3.1 Inactive 10.1126/SCIENCE.1261064 2015-02-11
6W2X GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CGP55845 pubchem
1-Stearoyl-2-oleoyl-... pubchem
Inverse agonistNAM 3.6 Inactive 10.1038/S41586-020-2469-4 2020-07-01
7VV5 MRGX2 MRGPRX2 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A compound 48/80 pubchem gtoplig
Agonist 2.8 Active 2021-12-01
6Z4S NTR1 NTS1 Neurotensin A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A meclinertant pubchem gtoplig chembl_ligand drugbank
Inverse agonist 2.7 Inactive 10.1126/sciadv.abe5504 2021-02-10
7AD3 STE2 STE2 STE2 D1 (Ste2-like fungal pheromone) strain ATCC 204508 / S288c N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Alpha-factor mating ... pubchem
Agonist 3.5 Active 10.1038/S41586-020-2994-1 2020-12-09
6RZ8 CLTR2 CysLT2 Leukotriene A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ONO-2080365 pubchem
Antagonist 2.7 Intermediate 10.1038/S41467-019-13348-2 2019-12-11
5T04 NTR1 NTS1 Neurotensin A (Rhodopsin) Rat BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 8.5-9.0 20°C neurotensin pubchem gtoplig chembl_ligand gtoplig gtoplig
Agonist 3.3 Active 10.1038/SREP38564 2016-12-21
6H7N ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (S)-Xamoterol pubchem
Agonist 2.5 Active 10.1101/436212 2018-10-17
6OIJ ACM1 M1 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A iperoxo pubchem gtoplig chembl_ligand
Agonist 3.3 Active 10.1126/SCIENCE.AAW5188 2019-05-08
6D35 Q98SW5 SMO Frizzled F (Frizzled) African clawed frog BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.0-6.5 20°C Cholesterol pubchem
Agonist 3.9 Active 10.1016/J.CELL.2018.04.029 2018-05-23
6AQF AA2AR A2A Adenosine A (Rhodopsin) Human Pichia PastorisP. pastoris SMD1163Yeast 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.0-5.0 20°C ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 2.5 Inactive 10.1016/J.CELL.2017.12.004 2018-01-10
6PS0 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A carazolol pubchem gtoplig chembl_ligand drug_central
Antagonist 3.4 Inactive 10.1107/S2052252519013137 2019-11-13
6KK7 GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PF-06372222 pubchem
NAM 3.1 Inactive 10.1107/S2052252519013496 2019-11-13
7RMG NK1R NK1 Tachykinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A substance P pubchem gtoplig chembl_ligand gtoplig gtoplig
Agonist 3.0 Active 10.1038/S41589-021-00890-8 2021-11-03
7W2Z GHSR ghrelin Ghrelin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Ghrelin pubchem
Agonist 2.8 Active 2022-01-19
5A8E ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 7.0-7.0 20°C 7-methylcyanopindolo... pubchem
Inverse agonist 2.4 Inactive 10.1124/MOL.115.101030 2015-09-30
6GPS CCR2 CCR2 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A MK-0812 pubchem
Antagonist 3.3 Inactive 10.1016/J.STR.2018.10.027 2019-01-02
7EO2 S1PR1 S1P1 Lysophospholipid (S1P) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (S)-FTY720-phosphate pubchem gtoplig chembl_ligand
Agonist 2.9 Active 10.1038/S41589-021-00930-3 2022-01-05
7TYH CALCR CT Calcitonin B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A calcitonin human pubchem
Agonist 3.3 Active 2022-03-23
3NYA ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.0-7.0 21-23°C CHEMBL1160734 chembl_ligand pubchem
Antagonist 3.2 Inactive 10.1021/JA105108Q 2010-08-11
6BD4 FZD4 FZD4 Frizzled F (Frizzled) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.4 Inactive 10.1038/S41586-018-0447-X 2018-08-22
6FKB OPSD Rhodopsin Opsins A (Rhodopsin) Bovine BaculovirusHEK293S(TetR)-GnTI-Mammalian 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 4.5-4.5 20°C 2-(4-Chlorophenyl)-1... pubchem
Agonist 3.0 Active 10.1073/PNAS.1718084115 2018-04-04
7M8W PD2R2 DP2 Prostanoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 15(<i>R</i>)-15-meth... pubchem gtoplig
Antagonist 2.6 Inactive 10.1073/PNAS.2102813118 2021-08-25
3PQR OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionHanging drops 3 chems 5.6-5.6 4°C Retinal (all-trans) pubchem
Agonist 2.9 Active 10.1038/NATURE09789 2011-03-09
7F8U CCKAR CCK1 Cholecystokinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A lintitript pubchem gtoplig chembl_ligand drugbank
Antagonist 2.8 Inactive 10.1038/S41589-021-00866-8 2021-10-13
6UOA GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL112710 chembl_ligand pubchem pubchem
Agonist 6.3 Inactive 10.1038/S41586-020-2408-4 2020-06-10
7F16 PTH2R PTH2 Parathyroid hormone B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A TIP39 gtoplig
Agonist 2.8 Active 10.1073/PNAS.2101279118 2021-08-18
7VV3 MRGX2 MRGPRX2 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Cortistatin 14 pubchem
Agonist 3.0 Active 2021-12-01
6FKA OPSD Rhodopsin Opsins A (Rhodopsin) Bovine BaculovirusHEK293S(TetR)-GnTI-Mammalian 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 4.5-4.5 20°C (2~{S})-2-(3,4-dichl... pubchem
Agonist 2.7 Active 10.1073/PNAS.1718084115 2018-04-04
6OS0 AGTR1 AT1 Angiotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Angiotensinogen pubchem
Agonist 2.9 Active 10.1126/SCIENCE.AAY9813 2020-02-19
6KUX ADA2A α2A Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A RSC pubchem
Antagonist 2.7 Inactive 2019-12-04
7UM5 5HT5A 5-HT5A 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5-CT pubchem gtoplig chembl_ligand
Agonist 2.7 Active 10.1038/S41594-022-00796-6 2022-07-20
5IU7 AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20°C 2-(Furan-2-yl)-5-N-[... pubchem
Antagonist 1.9 Inactive 10.1021/acs.jmedchem.6b00653 2016-06-29
7BU6 ADRB1 β1 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Noradrenaline pubchem
Agonist 2.7 Active 10.1038/S41422-020-00424-2 2020-12-02
4A4M OPSD Rhodopsin Opsins A (Rhodopsin) Bovine Stable_cellsHEK293TMammalian 1 chemicals 1 steps vapour diffusionsitting drop 3 chems 4.5-4.5 4°C Retinal (all-trans) pubchem
Agonist 3.3 Active 10.1073/PNAS.1114089108 2012-01-25
7DUR GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N-Tert-butyl-6,7-dic... pubchem
Ago-PAM 3.3 Active 10.1038/S41467-021-24058-Z 2021-08-11
7EVM GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N-Tert-butyl-6,7-dic... pubchem
Ago-PAM 2.5 Active 10.1038/S41467-021-24058-Z 2021-08-11
5K2D AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.0-5.0 20°C ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 1.9 Inactive 10.1126/SCIADV.1600292 2016-09-21
6WGT 5HT2A 5-HT2A 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Lysergide pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.4 Inactive 10.1016/J.CELL.2020.08.024 2020-09-23
7EW4 S1PR3 S1P3 Lysophospholipid (S1P) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CYM-5541 pubchem gtoplig chembl_ligand
Agonist 3.2 Active 10.1038/S41422-021-00567-W 2021-09-29
6DDF OPRM μ Opioid A (Rhodopsin) Mouse BaculovirusSf9Insect 4 chemicals 4 steps Cryo-EMGatan K2 Summit direct electron camera , 300kV 5 chems 7.5-7.5 4°C DAMGO pubchem gtoplig chembl_ligand chembl_ligand
Agonist 3.5 Active 10.1038/S41586-018-0219-7 2018-06-13
6WW2 FZD5 FZD5 Frizzled F (Frizzled) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.7 Inactive 10.7554/ELIFE.58464 2020-08-19
7C61 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ergotamine pubchem gtoplig chembl_ligand drugbank drug_central
Antagonist 3.0 Inactive 10.1038/S41598-020-68355-X 2020-07-29
7MTQ GRM2 mGlu2 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A LY341495 pubchem gtoplig chembl_ligand gtoplig
Antagonist 3.7 Inactive 10.1038/S41586-021-03680-3 2021-07-07
6KUW ADA2C α2C Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (8Ar,12aS,13aR)-12-e... pubchem
Antagonist 2.8 Inactive 2019-12-04
7VOE 5HT2A 5-HT2A 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A aripiprazole pubchem gtoplig chembl_ligand drugbank drug_central
Agonist (partial) 2.9 Inactive 10.1038/S41593-021-00971-W 2021-12-22
7DD6 CASR CaS Calcium-sensing C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Calcium pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem
AgonistPAM 3.2 Active 10.1126/SCIADV.ABG1483 2021-06-16
5YC8 ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N-methyl scopolamine pubchem gtoplig drugbank gtoplig
Antagonist 2.5 Inactive 10.1038/S41589-018-0152-Y 2018-11-21
7DDZ NPY2R Y2 Neuropeptide Y A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL1823578 chembl_ligand pubchem
Antagonist 2.8 Inactive 2021-01-27
7M3F CASR CaS Calcium-sensing C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Calcium pubchem
cinacalcet pubchem gtoplig chembl_ligand drugbank drug_central
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem
AgonistPAMPAM 2.8 Active 10.1038/S41586-021-03691-0 2021-06-30
6ME6 MTR1B MT2 Melatonin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2-phenylmelatonin pubchem
Agonist 2.8 Inactive 10.1038/S41586-019-1144-0 2019-04-24
4BV0 NTR1 NTS1 Neurotensin A (Rhodopsin) Rat NAE. coli BL21(DE3)Bacteria 3 chemicals 3 steps vapour diffusionsitting drops 5 chems 9.4-9.4 4°C neurotensin pubchem gtoplig chembl_ligand gtoplig gtoplig
Agonist 3.1 Inactive 10.1073/PNAS.1317903111 2014-01-29
7CKZ DRD1 D1 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A dopamine pubchem gtoplig chembl_ligand drugbank drug_central
LY3154207 pubchem gtoplig chembl_ligand
AgonistPAM 3.1 Active 10.1016/J.CELL.2021.01.028 2021-03-03
7TYW CALCR CT Calcitonin B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A calcitonin (salmon s... pubchem
Agonist 3.0 Active 10.1126/SCIENCE.ABM9609 2022-03-23
7WC9 5HT2A 5-HT2A 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (10~{R},15~{S})-12-[... pubchem
Agonist 2.5 Inactive 10.1126/SCIENCE.ABL8615 2022-01-26
6M1H PACR PAC1 VIP and PACAP B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Maxadilan pubchem
Agonist 3.6 Active 10.1038/S41422-020-0280-2 2020-03-11
6HLL NK1R NK1 Tachykinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CP 99994 pubchem gtoplig chembl_ligand
Antagonist 3.3 Inactive 10.1038/S41467-018-07939-8 2019-01-16
2YDO AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusHi5Insect 4 chemicals 4 steps vapour diffusionsitting drop 5 chems 7.6-7.6 4°C adenosine pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.0 Active 10.1038/NATURE10136 2011-05-18
7L1V OX2R OX2 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A compound 1 [PMID: 33... pubchem gtoplig
Agonist 3.0 Active 10.1038/S41467-021-21087-6 2021-02-10
6WHC GLR glucagon Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Dual-agonist peptide...
Agonist 3.4 Active 10.1074/JBC.RA120.013793 2020-05-27
4N4W SMO SMO Frizzled F (Frizzled) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 7 chems 6.9-6.9 20°C SANT-1 pubchem gtoplig chembl_ligand
Antagonist 2.8 Inactive 10.1038/NCOMMS5355 2014-01-22
4NC3 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 8.0-8.0 20°C ergotamine pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 2.8 Intermediate 10.1126/SCIENCE.1244142 2013-12-18
6OS9 NTR1 NTS1 Neurotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A JMV449 pubchem gtoplig chembl_ligand
Agonist 3.0 Active 10.1038/S41586-019-1337-6 2019-07-10
7KI1 GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Taspoglutide pubchem
Agonist 2.5 Active 10.1016/J.CELREP.2021.109374 2021-08-04
6WJC ACM1 M1 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ENDO-ATROPINE chembl_ligand pubchem
muscarinic toxin 7 gtoplig
AntagonistNAM 2.6 Inactive 10.1126/SCIENCE.AAX2517 2020-07-08
7WF7 S1PR1 S1P1 Lysophospholipid (S1P) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A sphingosine 1-phosph... pubchem gtoplig chembl_ligand pubchem
Agonist 3.4 Active 10.1038/S41589-021-00930-3 2022-01-05
4BEY OPSD Rhodopsin Opsins A (Rhodopsin) Bovine Stable_cellsHEK293S(TetR)GnTI-Mammalian 1 chemicals 1 steps vapour diffusionsitting drop 4 chems 4.5-4.5 20°C Apo (no ligand)
Apo (no ligand) 2.9 Active 10.1038/EMBOR.2013.44 2013-05-08
5ZBQ NPY1R Y1 Neuropeptide Y A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 7.4-8.0 19–22 °C CHEMBL3747822 chembl_ligand chembl_ligand chembl_ligand pubchem
Antagonist 2.7 Inactive 10.1038/S41586-018-0046-X 2018-04-25
7JV5 DRD1 D1 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL1160787 chembl_ligand pubchem
Agonist 3.0 Active 10.1016/J.CELL.2021.01.027 2021-02-24
5TE5 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionHanging drop 4 chems 5.2-6.6 4°C 10,20-Methanoretinal pubchem
Agonist 4.0 Inactive 10.1073/PNAS.1617446114 2017-03-15
6DRZ 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A methysergide pubchem gtoplig chembl_ligand drugbank drug_central
Antagonist 3.1 Intermediate 10.1038/s41594-018-0116-7 2018-08-29
5XPR EDNRB ETB Endothelin A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.0-7.0 20°C Apo (no ligand)
Apo (no ligand) 3.6 Inactive 10.1038/NSMB.3450 2017-08-16
7RA3 GIPR GIP Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GIP pubchem pubchem
Agonist 3.2 Active 10.1073/PNAS.2116506119 2022-04-13
6PS5 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A propranolol pubchem gtoplig chembl_ligand drugbank drug_central pubchem gtoplig chembl_ligand pubchem pubchem pubchem
Antagonist 2.9 Inactive 10.1107/S2052252519013137 2019-11-13
5ZKQ PTAFR PAF Platelet-activating factor A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ABT-491 pubchem gtoplig chembl_ligand
Inverse agonist 2.9 Intermediate 10.1038/S41594-018-0068-Y 2018-06-20
7UM4 5HT5A 5-HT5A 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL3654198 chembl_ligand pubchem
Antagonist 2.8 Inactive 10.1038/S41594-022-00796-6 2022-07-20
3NY9 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.5-8.0 20°C CHEMBL1233771 chembl_ligand pubchem
Inverse agonist 2.8 Inactive 10.1021/JA105108Q 2010-08-11
7RKM US28 US28 Unclassified A (Rhodopsin) strain AD169 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Fractalkine pubchem
Agonist 3.5 Active 10.1126/SCIADV.ABL5442 2022-01-26
7EW0 S1PR1 S1P1 Lysophospholipid (S1P) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ozanimod pubchem gtoplig drug_central chembl_ligand drugbank
Agonist 3.4 Active 10.1038/S41422-021-00566-X 2021-09-29
6O3C SMO SMO Frizzled F (Frizzled) Mouse N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SAG21k pubchem
Agonist 2.8 Active 10.1038/S41586-019-1355-4 2019-07-03
7TD2 LPAR1 LPA1 Lysophospholipid (LPA) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (2r)-2-Hydroxy-3-(Ph... pubchem
Agonist 3.1 Active 10.1038/S41467-022-28417-2 2022-02-09
7WC5 5HT2A 5-HT2A 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A psilocin pubchem gtoplig chembl_ligand
Agonist 3.2 Inactive 10.1126/SCIENCE.ABL8615 2022-01-26
6V9S OX1R OX1 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A JH112 pubchem gtoplig
Antagonist 3.5 Inactive 10.1073/PNAS.2002704117 2020-07-15
4EIY AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.0-5.0 20°C ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 1.8 Inactive 10.1126/SCIENCE.1219218 2012-07-25
6M9T PE2R3 EP3 Prostanoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Misoprostol-FA pubchem
Agonist 2.5 Active 10.1038/S41589-018-0160-Y 2018-12-05
6N52 GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.0 Inactive 10.1038/S41586-019-0881-4 2019-01-23
7EPC GRM7 mGlu7 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 4.0 Inactive 10.1038/S41586-021-03641-W 2021-06-23
7P02 NK1R NK1 Tachykinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A substance P pubchem gtoplig chembl_ligand gtoplig gtoplig
Agonist 2.9 Active 10.1126/SCIADV.ABK2872 2021-12-15
7D77 AGRG3 ADGRG3 ADGRG B2 (Adhesion) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A HYDROCORTISONE chembl_ligand pubchem
Agonist 2.9 Active 10.1038/S41586-020-03083-W 2021-02-03
5VEW GLP1R GLP-1 Glucagon B1 (Secretin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 6.2-6.6 20°C PF-06372222 pubchem
NAM 2.7 Inactive 10.1038/NATURE22378 2017-05-24
7CZ5 GHRHR GHRH Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Somatoliberin pubchem
Agonist 2.6 Active 10.1038/S41467-020-18945-0 2020-11-18
6FK7 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine BaculovirusHEK293S(TetR)-GnTI-Mammalian 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 4.5-4.5 20°C (2~{S})-2-(4-chlorop... pubchem
Agonist 2.6 Active 10.1073/PNAS.1718084115 2018-04-04
5F8U ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 1 chemicals 1 steps vapour diffusionHanging drops 1 chems 3.6-4.0 18°C (S)-Cyanopindolol pubchem
Antagonist 3.4 Inactive 10.1038/NSMB.3130 2015-12-23
7SF8 AGRG1 ADGRG1 ADGRG B2 (Adhesion) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 2.7 Active 10.1038/S41586-022-04575-7 2022-04-27
6TPK OXYR OT Vasopressin and oxytocin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A retosiban pubchem gtoplig chembl_ligand drugbank
Antagonist 3.2 Inactive 10.1126/SCIADV.ABB5419 2020-08-05
6WQA AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 2.0 Inactive 10.1107/S2052252520012701 2020-11-18
7S8O MRGX2 MRGPRX2 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (R)-ZINC-3573 pubchem gtoplig chembl_ligand
Agonist 2.6 Active 10.1038/S41586-021-04126-6 2021-11-17
4RWD OPRD δ Opioid A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.0-6.0 20°C DIPP-NH2
Antagonist 2.7 Inactive 10.1038/NSMB.2965 2015-01-14
7L0S NTR1 NTS1 Neurotensin A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A neurotensin pubchem gtoplig chembl_ligand gtoplig gtoplig
Agonist 4.5 Active 2021-01-06
7WU3 AGRF1 ADGRF1 ADGRF B2 (Adhesion) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.1 Active 10.1038/S41586-022-04580-W 2022-04-27
4Z36 LPAR1 LPA1 Lysophospholipid (LPA) A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.5-5.5 20°C ONO-3080573 pubchem gtoplig
Antagonist 2.9 Inactive 10.1016/J.CELL.2015.06.002 2015-06-03
6D32 Q98SW5 SMO Frizzled F (Frizzled) African clawed frog BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.0-6.5 20°C cyclopamine pubchem gtoplig chembl_ligand
Agonist (partial) 3.8 Active 10.1016/J.CELL.2018.04.029 2018-05-23
6ME4 MTR1A MT1 Melatonin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2-iodo-melatonin pubchem gtoplig chembl_ligand drugbank
Agonist 3.2 Inactive 10.1038/S41586-019-1141-3 2019-04-24
7DFL HRH1 H1 Histamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A histamine pubchem gtoplig chembl_ligand drug_central drugbank gtoplig
Agonist 3.3 Active 2021-03-31
7EXD 5HT1F 5-HT1F 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A lasmiditan pubchem gtoplig chembl_ligand drug_central drugbank
Agonist 3.4 Active 10.1038/S41422-021-00527-4 2021-08-04
7WQ4 GALR2 GAL2 Galanin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A galanin gtoplig chembl_ligand gtoplig pubchem pubchem pubchem pubchem pubchem
Agonist 2.6 Active 2022-04-20
4QIM SMO SMO Frizzled F (Frizzled) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 5 chems 7.2-7.2 20°C ANTA XV pubchem gtoplig chembl_ligand
Antagonist 2.6 Inactive 10.1038/NCOMMS5355 2014-07-23
7DTV CASR CaS Calcium-sensing C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Calcium pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem
AgonistPAM 3.5 Inactive 10.1038/S41422-021-00474-0 2021-03-10
6KPF CNR2 CB2 Cannabinoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A AM841 pubchem gtoplig
Agonist 2.9 Active 10.1016/J.CELL.2020.01.008 2020-02-12
4PXF OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionsitting drop 3 chems 6.0-6.0 4°C B-Octylglucoside pubchem
unknown 2.8 Active 10.1038/NCOMMS5801 2014-09-17
7TD4 S1PR1 S1P1 Lysophospholipid (S1P) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A siponimod pubchem gtoplig chembl_ligand drug_central drugbank
Agonist 2.6 Active 10.1038/S41467-022-28417-2 2022-02-09
7JHJ Q3KSP2 BILF1 Unclassified A (Rhodopsin) strain GD1 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.2 Active 10.1016/J.IMMUNI.2021.06.001 2021-07-07
4DKL OPRM μ Opioid A (Rhodopsin) Mouse BaculovirusSf9Insect 12 chemicals 12 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.0-7.0 20°C Methyl 4-[[(4R,4aS,7... pubchem
Antagonist 2.8 Inactive 10.1038/NATURE10954 2012-03-21
7VUH GP139 GPR139 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A JNJ-63533054 pubchem gtoplig chembl_ligand
Agonist 3.2 Active 10.1038/S41422-021-00591-W 2021-12-29
6H7M ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A levosalbutamol pubchem gtoplig chembl_ligand drug_central drugbank
Agonist 2.8 Active 10.1126/SCIENCE.AAU5595 2018-10-17
6NI3 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A BI-167107 pubchem
Agonist 3.8 Active 10.1038/S41594-019-0330-Y 2019-11-20
7EO4 S1PR1 S1P1 Lysophospholipid (S1P) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A siponimod pubchem gtoplig chembl_ligand drug_central drugbank
Agonist 2.9 Active 10.1038/S41589-021-00930-3 2022-01-05
7F83 GHSR ghrelin Ghrelin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PF-05190457 pubchem gtoplig chembl_ligand drugbank
Inverse agonist 2.9 Inactive 10.1038/S41467-022-27975-9 2022-01-19
5L7I SMO SMO Frizzled F (Frizzled) Human Transient_transfectionHEK293S(TetR)-GnTI-Mammalian 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 8 chems 6.0-6.0 20°C vismodegib pubchem gtoplig chembl_ligand drugbank drug_central
Antagonist 3.3 Inactive 10.1038/NATURE18934 2016-07-20
4PY0 P2Y12 P2Y12 P2Y A (Rhodopsin) Human BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.0-6.0 20°C 2MeSATP pubchem gtoplig chembl_ligand
Agonist (partial) 3.1 Intermediate 10.1038/NATURE13288 2014-04-30
5ZKB ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A AF-DX 384 pubchem
Antagonist 3.0 Inactive 10.1038/S41589-018-0152-Y 2018-11-21
7VL8 CCR1 CCR1 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 2.9 Active 10.1038/S41589-021-00918-Z 2022-03-23
7F1Q CCR5 CCR5 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CCL3 gtoplig
Agonist 2.9 Active 10.1038/S41467-021-24438-5 2021-07-14
6LI1 GPR52 GPR52 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 2.9 Inactive 10.1038/S41586-020-2019-0 2020-02-26
4JKV SMO SMO Frizzled F (Frizzled) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 6 chems 7.4-7.4 20°C taladegib pubchem gtoplig chembl_ligand drugbank
Antagonist 2.5 Inactive 10.1038/NATURE12167 2013-04-24
7EVZ S1PR1 S1P1 Lysophospholipid (S1P) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A cenerimod pubchem gtoplig chembl_ligand drugbank
Agonist 3.1 Active 10.1038/S41422-021-00566-X 2021-09-29
4XEE NTR1 NTS1 Neurotensin A (Rhodopsin) Rat BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.0-8.0 20°C neurotensin pubchem gtoplig chembl_ligand gtoplig gtoplig
Agonist 2.9 Active 10.1038/NCOMMS8895 2015-07-29
6MH8 AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 4.2 Inactive 10.1107/S205225251900263X 2019-04-24
7WI8 GRM3 mGlu3 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A LY341495 pubchem gtoplig chembl_ligand gtoplig
Antagonist 4.2 Inactive 10.1038/S41422-022-00623-Z 2022-03-16
7SF7 AGRL3 ADGRL3 ADGRL B2 (Adhesion) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 2.9 Active 10.1038/S41586-022-04575-7 2022-04-27
7PYR AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Preladenant conjugat...
Antagonist 2.6 Inactive 10.1002/ANIE.202115545 2022-03-02
5ZK8 ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N-methyl scopolamine pubchem gtoplig drugbank gtoplig
Antagonist 3.0 Inactive 10.1038/S41589-018-0152-Y 2018-11-21
7EVW FZD7 FZD7 Frizzled F (Frizzled) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.2 Active 10.1038/S41422-021-00525-6 2021-08-04
6OBA ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A AS408 pubchem gtoplig
CHEMBL1160734 chembl_ligand pubchem
NAMAntagonist 3.1 Inactive 10.1038/S41589-020-0549-2 2020-03-25
3ZPR ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 1 chemicals 1 steps vapour diffusionsitting drops 3 chems 9.0-9.0 4°C CHEMBL1559535 chembl_ligand pubchem
Antagonist 2.7 Inactive 10.1021/jm400140q 2013-04-03
7BVQ ADRB1 β1 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Carazolol pubchem
Inverse agonist 2.5 Inactive 10.1038/S41422-020-00424-2 2020-12-02
6TQ4 OX1R OX1 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL4590386 chembl_ligand pubchem
Antagonist 2.3 Inactive 10.1021/acs.jmedchem.9b01787 2020-01-01
5XSZ Q08BG4 LPA6 Lysophospholipid (LPA) A (Rhodopsin) Zebrafish BaculovirusSf9Insect 8 chemicals 8 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 6 chems 6.0-6.0 20°C Apo (no ligand)
Apo (no ligand) 3.2 Intermediate 10.1038/NATURE23448 2017-08-16
7C7S GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CGP 54626A pubchem gtoplig chembl_ligand gtoplig
Antagonist 2.9 Inactive 10.1038/S41422-020-0350-5 2020-07-01
6YVR NTR1 NTS1 Neurotensin A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A JMV431 gtoplig chembl_ligand pubchem
Agonist 2.5 Inactive 10.1126/sciadv.abe5504 2021-02-10
5ZK3 ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL558910 chembl_ligand pubchem
Antagonist 2.6 Inactive 10.1038/S41589-018-0152-Y 2018-11-21
4GBR ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 6.5-6.5 20°C Carazolol pubchem
Inverse agonist 4.0 Inactive 10.1371/JOURNAL.PONE.0046039 2012-10-24
6QZH CCR7 CCR7 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SCHEMBL13407377 pubchem
Allosteric antagonist 2.1 Inactive 10.1016/J.CELL.2019.07.028 2019-09-04
6ME3 MTR1A MT1 Melatonin A (Rhodopsin) Human N/A N/A N/A