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| RECEPTOR | EXPRESSION | SOLUBILIZATION | PURIFICATION | STRUCTURE DETERMINATION | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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RECEPTOR | EXPRESSION | SOLUBILIZATION | PURIFICATION | STRUCTURE DETERMINATION | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PDB |
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| pH | Temp |
| Resolution |
| Reference | Date | |||||
| 3VW7 | PAR1 | PAR1 | Proteinase-activated | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.5 | 20°C |
vorapaxar
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Antagonist | 2.2 | Active | 10.1038/NATURE11701 | 2012-12-12 | |
| 9IZH | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lysophosphatidic aci...
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.JSB.2024.108164 | 2025-01-01 | |
| 6DRX | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lisuride
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 3.1 | Intermediate | 10.1038/s41594-018-0116-7 | 2018-08-29 | |
| 6X19 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHU-128
pubchem
|
Agonist | 2.1 | Active | 10.1016/J.MOLCEL.2020.09.020 | 2020-09-09 | |
| 5IU4 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20 |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.7 | Inactive | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | |
| 7S15 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL5191519
chembl_ligand
pubchem
|
Agonist | 3.8 | Active | 10.1021/acs.jmedchem.1c01856 | 2022-06-08 | |
| 7YAE | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Octreotide
|
Agonist | 3.4 | Active | 10.1038/S41467-023-36673-Z | 2023-04-19 | |
| 8IW9 | TAAR9 | TAAR9 | A orphans | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cadaverine
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41586-023-06106-4 | 2023-05-31 | |
| 6K41 | ADA2B | α2B | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dexmedetomidine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41589-020-0492-2 | 2020-04-15 | |
| 7RKN | US28 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Fractalkine
pubchem
|
Agonist | 3.6 | Active | 10.1126/SCIADV.ABL5442 | 2022-01-26 | |
| 7X5H | 5HT5A | 5-HT5A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-CT
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.1 | Active | 10.1038/S41421-022-00412-3 | 2022-09-14 | |
| 7VBI | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
tirzepatide
pubchem
gtoplig
|
Agonist | 3.0 | Active | 10.1038/S41467-022-28683-0 | 2022-03-02 | |
| 2G87 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 6.5-7.5 | 283 K |
Retinal (all-trans)
pubchem
|
Agonist | 2.6 | Inactive | 10.1002/ANIE.200600595 | 2006-09-02 | ||
| 8IHK | HCAR3 | HCA3 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5S)-5-methyl-4-oxo-...
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41467-023-41650-7 | 2023-08-30 | |
| 8JZ7 | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MK 6892
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41392-023-01625-Y | 2023-10-04 | |
| 6HLO | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
aprepitant
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 2.4 | Inactive | 10.1038/S41467-018-07939-8 | 2019-01-16 | |
| 7LLY | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Pro-glucagon
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41467-021-27760-0 | 2022-01-12 | |
| 7EVM | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-Tert-butyl-6,7-dic...
pubchem
|
Ago-PAM | 2.5 | Active | 10.1038/S41467-021-24058-Z | 2021-08-11 | |
| 4MQS | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.2-7.9 | 20°C |
iperoxo
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.5 | Active | 10.1038/NATURE12735 | 2013-11-27 | |
| 7XW9 | TRFR | TRH1 | Thyrotropin-releasing hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
TRH
pubchem
|
Agonist | 2.7 | Active | 2022-12-28 | ||
| 3C9M | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | NA | NA | 1 chemicals | 1 steps | NA | NA | NA | 1 chems | 0.0-0.0 | NA |
Retinal (11-cis)
pubchem
|
Inverse agonist | 3.4 | Inactive | 10.1107/S0907444908017162 | 2008-08-05 | |
| 8IRJ | GP179 | GPR179 | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.5 | Inactive | 2024-09-18 | ||
| 7CKX | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
A77636
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.5 | Active | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | |
| 8GGR | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8X64 | HRH1 | H1 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
desloratadine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 3.4 | Inactive | 10.1038/S41467-023-44477-4 | 2024-01-17 | |
| 8XVK | EDNRA | ETA | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ambrisentan
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Antagonist | 3.2 | Inactive | 2024-08-28 | ||
| 9IJD | ADRB3 | β3 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Carazolol
pubchem
|
Inverse agonist | 2.8 | Active | 10.1002/CPLU.202400288 | 2024-08-21 | |
| 8S4D | APJ | apelin | Apelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CMF-019
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.6 | Inactive | 2024-12-04 | ||
| 8FYN | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.0 | Inactive | 10.1038/S41467-023-36733-4 | 2023-03-08 | |
| 7RYC | OXYR | OT | Vasopressin and oxytocin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
oxytocin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41594-022-00728-4 | 2022-03-09 | |
| 8POK | HRH2 | H2 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
histamine
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
gtoplig
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41467-024-46096-Z | 2024-03-06 | |
| 8JHC | FZD3 | FZD3 | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.3 | Active | 10.1038/S41421-023-00627-Y | 2024-01-17 | |
| 8T3S | FFAR2 | FFA2 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
butyric acid
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.1 | Active | 10.1126/SCIADV.ADJ2384 | 2024-01-24 | |
| 3NYA | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 21-23°C |
CHEMBL1160734
chembl_ligand
pubchem
|
Antagonist | 3.2 | Inactive | 10.1021/JA105108Q | 2010-08-11 | |
| 7FII | LSHR | LH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Glycoprotein alpha
gtoplig
Choriogonadotropin b... gtoplig |
AgonistAgonist | 4.3 | Active | 10.1038/S41586-021-03924-2 | 2021-09-29 | |
| 8IY5 | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ENDOTHELIN
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.7554/ELIFE.85821 | 2023-08-16 | |
| 8XGR | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ENDOTHELIN
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 2024-04-03 | ||
| 7XKF | AGRG2 | ADGRG2 | ADGRG | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PRASTERONE
chembl_ligand
pubchem
|
Agonist | 2.4 | Active | 10.1038/S41589-022-01084-6 | 2022-08-10 | |
| 5NM2 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.0 | Inactive | 10.1038/S41467-017-00630-4 | 2017-09-27 | |
| 8YY8 | FZD7 | FZD7 | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 10.1038/S41422-021-00525-6 | 2024-04-24 | |
| 7EWR | GP158 | GPR158 | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 4.7 | Inactive | 10.1038/S41467-021-27147-1 | 2021-12-01 | |
| 7BVQ | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Carazolol
pubchem
|
Inverse agonist | 2.5 | Inactive | 10.1038/S41422-020-00424-2 | 2020-12-02 | |
| 7RM5 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.8 | Inactive | 10.1073/PNAS.2106041118 | 2021-09-08 | |
| 9IYB | PD2R2 | DP2 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PGD2
|
Agonist | 2.8 | Active | 2024-12-04 | ||
| 7CUM | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CGP 54626A
pubchem
gtoplig
chembl_ligand
gtoplig
Unknown ligand |
NAMNAM | 3.5 | Inactive | 10.1016/J.JMB.2020.09.023 | 2020-11-11 | |
| 7YS6 | 5HT6R | 5-HT6 | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-hydroxytryptamine
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.0 | Active | 2023-03-29 | ||
| 9F34 | DRD3 | D3 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4551160
chembl_ligand
pubchem
|
Agonist | 3.1 | Active | 2024-09-18 | ||
| 4NC3 | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 8.0-8.0 | 20°C |
ergotamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.8 | Intermediate | 10.1126/SCIENCE.1244142 | 2013-12-18 | |
| 8IJB | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-Methyl-4-oxidanyl-...
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41421-023-00610-7 | 2024-01-03 | |
| 7YDH | AGRE5 | ADGRE5 | ADGRE | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 10.1016/J.CHEMBIOL.2023.08.003 | 2023-07-12 | |
| 6XBL | SMO | SMO | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SAG1.3
pubchem
gtoplig
chembl_ligand
Cholesterol pubchem |
PAMAgonist | 3.9 | Active | 10.1038/S41589-020-0646-2 | 2020-09-30 | |
| 2VT4 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | hanging drop | 4 chems | 6.9-7.3 | 18°C |
(S)-Cyanopindolol
pubchem
|
Antagonist | 2.7 | Inactive | 10.1038/NATURE07101 | 2008-06-24 | ||
| 8X8L | SSR5 | SST5 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cortistatin
|
Agonist | 2.7 | Active | 2024-06-12 | ||
| 7T6V | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
synthetic peptide
|
Agonist | 3.1 | Active | 10.1038/S41467-022-28586-0 | 2022-03-30 | |
| 8IBU | MTLR | motilin | Motilin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
erythromycin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.5 | Active | 10.1126/SCIADV.ADE9020 | 2023-04-12 | |
| 8JIS | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Dual-agonist peptide...
|
Agonist | 2.5 | Active | 10.1073/PNAS.2303696120 | 2023-11-08 | |
| 7Y66 | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
BM213
|
Agonist | 2.9 | Active | 10.1038/S41422-023-00779-2 | 2023-03-01 | |
| 8WC4 | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL476516
chembl_ligand
pubchem
|
Agonist | 3.1 | Active | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | |
| 8XFT | LGR4 | LGR4 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
R-spondin-2
|
Agonist | 3.2 | Inactive | 2024-12-04 | ||
| 6FK9 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
(2~{S})-3-methyl-2-p...
pubchem
|
Agonist | 2.6 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
| 6DO1 | AGTR1 | AT1 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL404594
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 10.1016/J.CELL.2018.12.006 | 2019-01-30 | |
| 6KNM | APJ | apelin | Apelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Single domain antibo...
|
Agonist | 3.2 | Inactive | 10.1126/SCIADV.AAX7379 | 2020-01-29 | |
| 8GEG | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.8 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8HNN | CXCR3 | CXCR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1921858
chembl_ligand
pubchem
|
Antagonist | 3.6 | Inactive | 10.1038/S41594-023-01175-5 | 2023-11-29 | |
| 8WWI | MCHR1 | MCH1 | Melanin-concentrating hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.4 | Active | 2024-11-13 | ||
| 7WI8 | GRM3 | mGlu3 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 4.2 | Inactive | 10.1038/S41422-022-00623-Z | 2022-03-16 | |
| 8GEE | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.7 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7SK3 | ACKR3 | ACKR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CXCL12α
gtoplig
|
Agonist | 3.8 | Active | 10.1126/SCIADV.ABN8063 | 2022-07-27 | |
| 7E33 | 5HT1E | 5-HT1E | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
BRL-54443
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.9 | Active | 10.1038/S41586-021-03376-8 | 2021-04-14 | |
| 8ITM | GIPR | GIP | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 10.1073/PNAS.2306145120 | 2023-10-18 | |
| 7D3S | SCTR | secretin | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SECRETIN
chembl_ligand
pubchem
drugbank
pubchem
|
Agonist | 2.9 | Active | 10.1016/J.BBRC.2020.08.042 | 2020-11-04 | |
| 4XT3 | US28 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monovaccenin(11.7 MAG) | 6 chems | 7.4-7.4 | 20°C |
CX3CL1
gtoplig
|
Agonist (partial) | 3.8 | Active | 2015-03-04 | ||
| 9AVG | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cyclomethyltryptopha...
pubchem
tecalcet pubchem gtoplig chembl_ligand |
AgonistPAM | 3.6 | Active | 2024-04-17 | ||
| 8X63 | HRH1 | H1 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
mepyramine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Antagonist | 3.2 | Inactive | 10.1038/S41467-023-44477-4 | 2024-01-17 | |
| 8UY0 | OR2T2 | OR2T2 | Odorant family 2 | O2 (tetrapod specific odorant) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5S)-2-methyl-5-(pro...
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41586-024-08126-0 | 2024-10-30 | |
| 8GGU | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 6TPG | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
EMPA
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.7 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
| 5WF5 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-5.0 | 20°C |
UK-432,097
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.6 | Active | 10.1016/J.STR.2017.12.013 | 2018-02-21 | |
| 7LJC | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1160787
chembl_ligand
pubchem
mevidalen pubchem gtoplig chembl_ligand pubchem |
AgonistPAM | 3.0 | Active | 10.1038/S41422-021-00482-0 | 2021-03-03 | |
| 5A8E | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 7.0-7.0 | 20°C |
7-methylcyanopindolo...
pubchem
gtoplig
|
Inverse agonist | 2.4 | Inactive | 10.1124/MOL.115.101030 | 2015-09-30 | |
| 8EFQ | OPRM | μ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
DAMGO
pubchem
gtoplig
chembl_ligand
chembl_ligand
|
Agonist | 3.3 | Active | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | |
| 7TUY | GP183 | GPR183 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
8-[(2E)-3-(4-chlorop...
pubchem
|
Inverse agonist | 3.0 | Active | 10.1016/J.STR.2022.04.006 | 2022-04-13 | |
| 7T90 | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
acetylcholine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 3.3 | Active | 2023-01-25 | ||
| 8GDC | PE2R3 | EP3 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PGE2
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 3.5 | Active | 10.1073/PNAS.2216329120 | 2024-01-10 | |
| 8CIC | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AB928
pubchem
gtoplig
chembl_ligand
pubchem
|
Antagonist | 2.1 | Inactive | 10.1038/S42004-023-00894-6 | 2023-05-31 | |
| 8UO4 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 4.0 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 4BWB | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | NA | E. coli BL21(DE3) | Bacteria | 3 chemicals | 3 steps | vapour diffusion | sitting drops | 7 chems | 5.5-5.5 | 4°C |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 3.6 | Inactive | 10.1073/PNAS.1317903111 | 2014-01-29 | ||
| 7S8N | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(R)-ZINC-3573
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.9 | Active | 10.1038/S41586-021-04126-6 | 2021-11-17 | |
| 8IYH | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MK 6892
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41467-024-46239-2 | 2024-03-06 | |
| 8HDO | AA2BR | A2B | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
BAY 60-6583
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.9 | Active | 10.1038/S41421-022-00503-1 | 2023-01-18 | |
| 8TH4 | AGTR1 | AT1 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AT118-L Nanobody
|
Antagonist | 3.3 | Inactive | 10.1038/S41589-024-01620-6 | 2024-05-22 | |
| 8THL | ADA1A | α1A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(-)-adrenaline
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41467-023-40524-2 | 2023-08-16 | |
| 7L0Q | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 4.3 | Active | 10.1038/S41594-020-00554-6 | 2021-01-06 | |
| 8J6Q | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
β-D-hydroxybuty...
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.6 | Active | 10.1038/S41467-023-43537-Z | 2023-12-06 | |
| 8UWL | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lisuride
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.8 | Active | 10.1126/SCIENCE.ADN6354 | 2024-05-29 | |
| 7UL5 | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Inactive | 10.1038/S41594-022-00859-8 | 2022-06-29 | |
| 8H2G | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
nicotinic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 3.0 | Active | 2023-10-11 | ||
| 8ZX5 | GPR55 | GPR55 | GPR18, GPR55 and GPR119 | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AM251
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 2024-11-13 | ||
| 7S8M | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cortistatin 14
pubchem
|
Agonist | 2.5 | Active | 10.1038/S41586-021-04126-6 | 2021-11-17 | |
| 5TE5 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drop | 4 chems | 5.2-6.6 | 4°C |
10,20-Methanoretinal
pubchem
|
Agonist | 4.0 | Inactive | 10.1073/PNAS.1617446114 | 2017-03-15 | ||
| 8YW4 | GIPR | GIP | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retatrutide
|
Agonist | 3.3 | Active | 10.1038/S41421-024-00700-0 | 2024-09-18 | |
| 8IRT | DRD3 | D3 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
rotigotine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41422-023-00808-0 | 2023-06-07 | |
| 6ME9 | MTR1B | MT2 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ramelteon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.3 | Inactive | 10.1038/S41586-019-1144-0 | 2019-04-24 | |
| 8EFO | OPRM | μ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PZM21
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.8 | Active | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | |
| 6RZ4 | CLTR1 | CysLT1 | Leukotriene | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
pranlukast
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 2.7 | Active | 10.1126/SCIADV.AAX2518 | 2019-10-30 | |
| 8YNT | MCHR1 | MCH1 | Melanin-concentrating hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL242004
chembl_ligand
pubchem
|
Antagonist | 3.4 | Inactive | 2024-12-18 | ||
| 8U4P | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
plerixafor
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41594-024-01397-1 | 2024-03-13 | |
| 7X9Y | CCR3 | CCR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 10.1038/S41421-022-00403-4 | 2022-08-24 | |
| 7MTB | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (all-trans)
pubchem
|
Agonist | 4.0 | Active | 10.1038/S41586-021-03721-X | 2021-07-07 | |
| 6N51 | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
quisqualate
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
pubchem
|
Agonist | 4.0 | Intermediate | 10.1038/S41586-019-0881-4 | 2019-01-23 | |
| 8J22 | FFAR2 | FFA2 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4176503
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41422-023-00914-Z | 2024-01-24 | |
| 7XMT | SSR4 | SST4 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
J-2156
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.8 | Active | 10.1038/S41422-022-00679-X | 2022-08-03 | |
| 8JPS | ACKR1 | ACKR1 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
C-C motif chemokine ...
|
Agonist | 3.7 | Intermediate | 10.1016/J.CELL.2024.07.005 | 2024-07-31 | |
| 7F61 | HRH3 | H3 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-ethyl-3-fluoro-3-[...
pubchem
|
Antagonist | 2.6 | Inactive | 10.1038/S41467-022-33880-Y | 2022-10-26 | |
| 7T8X | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
acetylcholine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 3.2 | Active | 2023-01-25 | ||
| 7QVM | OXYR | OT | Vasopressin and oxytocin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
oxytocin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41467-022-31325-0 | 2022-08-10 | |
| 5K2D | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.9 | Inactive | 10.1126/SCIADV.1600292 | 2016-09-21 | |
| 8X3L | CNR2 | CB2 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL5422946
chembl_ligand
pubchem
|
Agonist | 3.1 | Active | 10.1073/PNAS.2401091121 | 2024-11-20 | |
| 8X0H | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
quisqualate
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
pubchem
|
Agonist | 4.1 | Active | 10.1038/S41467-024-55439-9 | 2024-11-06 | |
| 8UNW | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7T96 | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
acetylcholine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
LY2119620 pubchem gtoplig chembl_ligand |
AgonistPAM | 3.2 | Active | 2023-01-25 | ||
| 8IHI | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5S)-5-methyl-4-oxo-...
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41467-023-41650-7 | 2023-08-30 | |
| 7SCG | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2E)-N-[(2S)-2-(dime...
pubchem
|
Agonist | 3.0 | Active | 10.1002/ANIE.202200269 | 2022-04-20 | |
| 5ZKC | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-methyl scopolamine
pubchem
gtoplig
drugbank
gtoplig
chembl_ligand
chembl_ligand
chembl_ligand
pubchem
pubchem
|
Antagonist | 2.3 | Inactive | 10.1038/S41589-018-0152-Y | 2018-11-21 | |
| 7YK6 | RL3R2 | RXFP4 | Relaxin family peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4522365
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41467-023-36182-Z | 2023-03-01 | |
| 8XOG | GPER1 | GPER | Estrogen (G protein-coupled) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1038/S41422-024-00963-Y | 2024-04-10 | |
| 8G94 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Early activation ant...
pubchem
|
Agonist | 3.2 | Active | 10.7554/ELIFE.88204 | 2023-04-19 | |
| 7CRH | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1416789
chembl_ligand
pubchem
|
Agonist | 3.3 | Active | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | |
| 5EN0 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Stable_cells | HEK293S(TetR)GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Sitting drop | 4 chems | 5.0-5.0 | 4°C |
Retinal (all-trans)
pubchem
|
Agonist | 2.8 | Active | 10.15252/EMBR.201642671 | 2016-08-10 | ||
| 8WC7 | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-[4-(3-Fluorophenyl...
pubchem
|
Agonist | 3.1 | Active | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | |
| 7XOW | GASR | CCK2 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
desulfated gastrin-1...
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41421-022-00420-3 | 2022-07-20 | |
| 7WIC | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SOMATOSTATIN
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41422-022-00669-Z | 2022-06-01 | |
| 8WGC | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY379268
pubchem
gtoplig
chembl_ligand
|
Agonist | 6.0 | Active | 10.1038/S41467-024-54744-7 | 2024-11-27 | |
| 7WC9 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
IHCH-7086
pubchem
|
Agonist | 2.5 | Inactive | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | |
| 7X2V | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 10.1038/S41467-022-33173-4 | 2022-09-28 | |
| 6GDG | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | Cryo-EM | Falcon III detector , 300kV, FEI TITAN Krios microscope, Volta PhasePlate, GIF-quantum energy filter (Gatan) | 4 chems | 7.5-7.5 | 4°C |
NECA
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 4.1 | Active | 10.7554/ELIFE.35946 | 2018-05-16 | ||
| 8XIP | SSR1 | SST1 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
004-DTR-LYS-TY5-PHE-...
|
Agonist | 3.3 | Active | 2024-07-03 | ||
| 7B6W | ADA1B | α1B | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(+)-cyclazosin
pubchem
gtoplig
chembl_ligand
|
Inverse agonist | 2.9 | Inactive | 10.1038/s41467-021-27911-3 | 2022-01-12 | |
| 8WVY | LGR4 | LGR4 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Norrin
|
Agonist | 3.3 | Inactive | 2024-10-30 | ||
| 1U19 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 6.5-7.5 | 283 K |
Retinal (11-cis)
pubchem
|
Inverse agonist | 2.2 | Inactive | 10.1016/J.JMB.2004.07.044 | 2004-10-12 | ||
| 7Y65 | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
C5a
|
Agonist | 3.2 | Active | 10.1038/S41422-023-00779-2 | 2023-03-01 | |
| 8WVX | LGR4 | LGR4 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Norrin
|
Agonist | 3.3 | Inactive | 2024-10-30 | ||
| 5XEZ | GLR | glucagon | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C |
NNC0640
pubchem
gtoplig
|
NAM | 3.0 | Inactive | 10.1038/NATURE22363 | 2017-05-24 | |
| 8J6I | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MK 6892
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 2024-04-03 | ||
| 7JV5 | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1160787
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.CELL.2021.01.027 | 2021-02-24 | |
| 6UO9 | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL112710
chembl_ligand
pubchem
pubchem
|
Agonist | 4.8 | Intermediate | 10.1038/S41586-020-2408-4 | 2020-06-10 | |
| 3RFM | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 6 chems | 8.0-8.8 | 4°C |
caffeine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 3.6 | Inactive | 10.1016/J.STR.2011.06.014 | 2011-09-07 | ||
| 8GG1 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8JCZ | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 3.0 | Inactive | 10.1038/S41422-023-00830-2 | 2023-06-21 | |
| 8YKX | SUCR1 | succinate | Succinate | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
maleic acid
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.7 | Active | 10.1038/S41422-024-00984-7 | 2024-05-29 | |
| 3C9L | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | NA | NA | 1 chemicals | 1 steps | NA | NA | NA | 1 chems | 0.0-0.0 | NA |
Retinal (11-cis)
pubchem
|
Inverse agonist | 2.7 | Inactive | 10.1107/S0907444908017162 | 2008-08-05 | |
| 5N2S | AA1R | A1 | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 7.5-7.5 | 20°C |
PSB36
pubchem
|
Agonist | 3.3 | Inactive | 10.1016/j.str.2017.06.012 | 2017-07-26 | |
| 8I9A | C3AR | C3a | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
EP54 ligand
|
Agonist | 3.6 | Active | 10.1016/J.CELL.2023.09.020 | 2023-10-18 | |
| 7Y36 | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Parathyroid hormone
pubchem
|
Agonist | 2.8 | Active | 2023-07-05 | ||
| 6K42 | ADA2B | α2B | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dexmedetomidine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 4.1 | Active | 2020-04-15 | ||
| 6E3Y | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcitonin gene-rela...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-018-0535-Y | 2018-09-19 | |
| 6UO8 | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL112710
chembl_ligand
pubchem
pubchem
GS39783 pubchem gtoplig chembl_ligand |
AgonistPAM | 3.6 | Active | 10.1038/S41586-020-2408-4 | 2020-06-10 | |
| 8GTI | CRFR1 | CRF1 | Corticotropin-releasing factor | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
8-(4-bromo-2,6-dimet...
pubchem
|
Antagonist | 2.2 | Inactive | 10.1038/S12276-023-01082-1 | 2023-09-13 | |
| 3D4S | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C |
timolol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Inverse agonist | 2.8 | Inactive | 10.1016/J.STR.2008.05.001 | 2008-06-17 | |
| 8GG8 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8GE3 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 3PWH | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 6 chems | 8.0-8.8 | 4°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 3.3 | Inactive | 10.1016/J.STR.2011.06.014 | 2011-09-07 | ||
| 7EJX | GPR88 | GPR88 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 2 [PMID: 24...
pubchem
gtoplig
chembl_ligand
|
Allosteric agonist | 2.4 | Active | 10.1038/S41467-022-30081-5 | 2022-04-13 | |
| 5N2R | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20 |
PSB36
pubchem
|
Antagonist | 2.8 | Inactive | 10.1016/j.str.2017.06.012 | 2017-07-26 | |
| 6KUX | ADA2A | α2A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
RS79948
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.7 | Inactive | 2019-12-04 | ||
| 8WSS | MCHR1 | MCH1 | Melanin-concentrating hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
pro-MCH
|
Agonist | 3.0 | Active | 10.1038/S41421-024-00679-8 | 2024-06-19 | |
| 8UH3 | 5HT1E | 5-HT1E | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SETIPTILINE
chembl_ligand
pubchem
|
Agonist | 3.3 | Active | 10.1126/SCIADV.ADK4855 | 2024-05-01 | |
| 7F8Y | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
DEVAZEPIDE
chembl_ligand
pubchem
|
Antagonist | 2.5 | Inactive | 10.1038/S41589-021-00866-8 | 2021-10-13 | |
| 6WPW | GLR | glucagon | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Glucagon derivative ...
|
Agonist | 3.1 | Active | 10.1126/SCIENCE.ABA3373 | 2020-08-12 | |
| 8K6M | NPY1R | Y1 | Neuropeptide Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
neuropeptide Y
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
pubchem
pubchem
pubchem
|
Agonist | 3.3 | Active | 2024-07-31 | ||
| 8G05 | GPR84 | GPR84 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
6-Octylimino-1,3-dia...
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41467-023-41201-0 | 2023-11-01 | |
| 7SF7 | AGRL3 | ADGRL3 | ADGRL | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1038/S41586-022-04575-7 | 2022-04-27 | |
| 7VUZ | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PAMP-12
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41586-021-04077-Y | 2021-12-01 | |
| 6OS2 | AGTR1 | AT1 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
TRV026
|
Agonist | 2.7 | Active | 10.1126/SCIENCE.AAY9813 | 2020-02-19 | |
| 8IQ4 | PF2R | FP | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Carboprost
pubchem
chembl_ligand
drugbank
chembl_ligand
pubchem
pubchem
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41467-023-43922-8 | 2024-01-31 | |
| 8K5C | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-Methyl-4-oxidanyl-...
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41467-023-42764-8 | 2023-11-22 | |
| 7ZBC | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (11-cis)
pubchem
|
Inverse agonist | 1.8 | Inactive | 10.1038/S41586-023-05863-6 | 2023-03-29 | |
| 5L7D | SMO | SMO | Frizzled | F (Frizzled) | Human | Transient_transfection | HEK293S(TetR)-GnTI- | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 4.0-4.0 | 20°C |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Inactive | 10.1038/NATURE18934 | 2016-07-20 | |
| 8K5B | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
nicotinic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41467-023-42764-8 | 2023-11-22 | |
| 9B9Z | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Zevaquenabant
pubchem
|
Inverse agonist | 3.3 | Inactive | 2024-11-20 | ||
| 4Z34 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.5-5.5 | 20°C |
ONO-9780307
pubchem
gtoplig
|
Antagonist | 3.0 | Inactive | 10.1016/J.CELL.2015.06.002 | 2015-06-03 | |
| 5WB2 | Q80KM9 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 6.0-6.0 | 16-20°C |
CX3CL1
gtoplig
|
Agonist | 3.5 | Active | 10.7554/ELIFE.35850 | 2018-06-13 | |
| 7C6A | AGTR2 | AT2 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL404594
chembl_ligand
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41598-020-68355-X | 2020-07-29 | |
| 7E6U | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 6.0 | Inactive | 10.7554/ELIFE.68578 | 2021-09-22 | |
| 7JOZ | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4453318
chembl_ligand
pubchem
|
Agonist | 3.8 | Active | 10.1038/S41467-021-23519-9 | 2021-04-14 | |
| 8E9X | ACM4 | M4 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL73538
chembl_ligand
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41586-022-05489-0 | 2022-11-30 | |
| 6MET | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Envelope glycoprotei...
|
Antagonist | 4.5 | Inactive | 10.1038/S41586-018-0804-9 | 2018-12-12 | |
| 8GEH | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 4.0 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8TAO | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
quisqualate
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
pubchem
CDPPB pubchem gtoplig chembl_ligand |
AgonistAgonist | 2.9 | Active | 10.1101/2023.08.29.555158 | 2023-10-11 | |
| 7YU6 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2~{R})-2-[5-(2-hex...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41467-022-33121-2 | 2022-10-05 | |
| 8JLR | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(1~{S},3~{R})-3-(1-a...
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41586-023-06804-Z | 2023-11-15 | |
| 7VVJ | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PTHrP[1-36]
|
Agonist | 3.2 | Active | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | |
| 2YCX | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | NA | 3 chems | 6.9-7.3 | NA |
(S)-Cyanopindolol
pubchem
|
Antagonist | 3.3 | Inactive | 2011-06-01 | |||
| 3NY8 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.5-8.0 | 20°C |
ICI 118551
pubchem
gtoplig
chembl_ligand
chembl_ligand
pubchem
|
Inverse agonist | 2.8 | Inactive | 10.1021/JA105108Q | 2010-08-11 | |
| 4GBR | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 6.5-6.5 | 20°C |
Carazolol
pubchem
|
Inverse agonist | 4.0 | Inactive | 10.1371/JOURNAL.PONE.0046039 | 2012-10-24 | |
| 8KGK | GPR61 | GPR61 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 10.1038/S41467-023-41654-3 | 2023-10-11 | |
| 7VIE | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
sphingosine 1-phosph...
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 10.1073/PNAS.2117716119 | 2022-09-28 | |
| 5NLX | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.1 | Inactive | 10.1038/S41467-017-00630-4 | 2017-09-27 | |
| 8K4S | MRGX4 | MRGPRX4 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
DCA-3P
pubchem
|
Agonist | 2.9 | Active | 10.1016/J.CELL.2024.10.001 | 2024-11-06 | |
| 7YU3 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2~{R})-2-[5-(2-hex...
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41467-022-33121-2 | 2022-10-05 | |
| 8HMV | GPR21 | GPR21 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1002/MCO2.205 | 2023-03-01 | |
| 8GEJ | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 4.2 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 5NX2 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | vapour diffusion | Sitting drop | 4 chems | 8.0-9.0 | 10°C |
Truncated protein ag...
|
Agonist | 3.7 | Intermediate | 10.1038/NATURE22800 | 2017-06-14 | ||
| 8HAF | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PTHrP-(1-36)
pubchem
gtoplig
|
Agonist | 3.3 | Active | 10.1038/S41401-022-01032-Z | 2022-12-21 | |
| 8GCM | PE2R4 | EP4 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5S)-5-[(3R)-4,4-dif...
pubchem
|
Agonist | 3.5 | Active | 10.1073/PNAS.2216329120 | 2024-01-03 | |
| 6TQ7 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SB-334867
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.7 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
| 8JER | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-Methyl-4-oxidanyl-...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41467-024-46239-2 | 2024-03-06 | |
| 7VUG | GP139 | GPR139 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JNJ-63533054
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.2 | Active | 10.1038/S41422-021-00591-W | 2021-12-29 | |
| 6WZG | SCTR | secretin | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SECRETIN
chembl_ligand
pubchem
drugbank
pubchem
|
Agonist | 2.3 | Active | 10.1038/S41467-020-17791-4 | 2020-08-12 | |
| 7X9B | NPY2R | Y2 | Neuropeptide Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
neuropeptide Y
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
pubchem
pubchem
pubchem
|
Agonist | 3.4 | Active | 10.1126/SCIADV.ABM1232 | 2022-05-18 | |
| 7TD2 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lysophosphatidic aci...
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41467-022-28417-2 | 2022-02-09 | |
| 8GW8 | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PCO371
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.9 | Active | 10.1038/S41586-023-06169-3 | 2023-06-14 | |
| 7EW7 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SEW2871
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.3 | Active | 10.1038/S41422-021-00566-X | 2021-09-29 | |
| 7RKF | US28 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Fractalkine
pubchem
|
Agonist | 4.0 | Active | 10.1126/SCIADV.ABL5442 | 2022-01-26 | |
| 8XML | CCR8 | CCR8 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.6 | Active | 2025-01-01 | ||
| 5D5A | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.5-7.0 | 20°C |
Carazolol
pubchem
|
Inverse agonist | 2.5 | Inactive | 10.1107/S2059798315021683 | 2016-01-13 | |
| 8X8N | SSR5 | SST5 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Octreotide
pubchem
|
Agonist | 2.9 | Active | 2024-06-12 | ||
| 7RG9 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 10.1073/PNAS.2116506119 | 2022-04-13 | |
| 8W8A | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3684869
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41586-023-06775-1 | 2023-11-22 | |
| 8Y53 | BRS3 | BB3 | Bombesin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MK-5046
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.9 | Active | 2024-09-11 | ||
| 7P2L | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
alloswitch-1
pubchem
gtoplig
|
NAM | 2.5 | Inactive | 10.1016/J.CELREP.2021.109648 | 2021-09-08 | |
| 7F54 | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
afamelanotide
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
pubchem
pubchem
pubchem
pubchem
|
Agonist | 3.0 | Active | 2021-11-03 | ||
| 6VI4 | OPRK | κ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JDTic
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.3 | Inactive | 10.1038/S41467-020-14889-7 | 2020-03-18 | |
| 7ARO | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL124345
chembl_ligand
pubchem
|
Agonist (partial) | 3.1 | Inactive | 10.1021/acs.jmedchem.0c01856 | 2021-04-07 | |
| 6LPB | PACR | PAC1 | VIP and PACAP | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[Ac-His<sup>1</sup>]...
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.9 | Active | 10.1038/S41594-020-0386-8 | 2020-03-11 | |
| 6UUN | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Adrenomedullin
pubchem
|
Agonist | 3.0 | Active | 10.1021/ACSPTSCI.9B00080 | 2020-03-25 | |
| 8V6U | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
4-{(3R)-1-[(1R)-1-(p...
pubchem
|
Agonist | 3.0 | Active | 10.1126/SCIENCE.ADN6354 | 2024-05-29 | |
| 7F4I | MSHR | MC1 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
bremelanotide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41422-021-00557-Y | 2021-09-08 | |
| 7MTR | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-glutamic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
2-methoxy-6-propyl-N... pubchem |
AgonistAgo-PAM | 3.3 | Active | 10.1038/S41586-021-03680-3 | 2021-07-07 | |
| 5WIU | DRD4 | D4 | Dopamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 5.8-6.2 | 20°C |
[3H]NEMONAPRIDE
chembl_ligand
pubchem
|
Antagonist | 2.0 | Inactive | 10.1126/SCIENCE.AAN5468 | 2017-10-18 | |
| 8HAO | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
teriparatide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
pubchem
pubchem
pubchem
pubchem
pubchem
|
Agonist | 3.8 | Active | 10.1038/S41401-022-01032-Z | 2022-12-21 | |
| 8IUL | PF2R | FP | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
latanoprost (free ac...
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.8 | Active | 10.1038/S41467-023-38411-X | 2023-07-12 | |
| 7SRR | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Lysergide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.9 | Active | 10.1016/J.NEURON.2022.08.006 | 2022-09-21 | |
| 5MZP | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20 |
caffeine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 2.1 | Inactive | 10.1016/j.str.2017.06.012 | 2017-07-26 | |
| 5TVN | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.5-8.0 | 20°C |
Lysergide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.9 | Intermediate | 10.1016/J.CELL.2016.12.033 | 2017-02-01 | |
| 8YUV | HRH3 | H3 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
immepip
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 2024-06-05 | ||
| 7D7M | PE2R4 | EP4 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PGE2
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 3.3 | Active | 10.1016/J.STR.2020.11.007 | 2020-11-18 | |
| 9EPO | FZD7 | FZD7 | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 1.9 | Inactive | 2024-10-02 | ||
| 8W77 | O52E4 | OR52E4 | Odorant family 52 | O1 (fish-like odorant) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.6 | Inactive | 10.1038/S41467-023-43983-9 | 2023-12-20 | |
| 6FKC | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
3-[1'-[(2~{S})-2-(4-...
pubchem
|
Agonist | 2.5 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
| 7SK9 | ACKR3 | ACKR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(1R)-4-[7-(3-carboxy...
pubchem
|
Agonist (partial) | 3.7 | Active | 10.1126/SCIADV.ABN8063 | 2022-07-27 | |
| 8YN6 | HRH3 | H3 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
imetit
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-024-52585-Y | 2024-10-09 | |
| 7TRS | ACM4 | M4 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
acetylcholine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 2.8 | Active | 2023-05-17 | ||
| 7UM6 | 5HT5A | 5-HT5A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lisuride
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41594-022-00796-6 | 2022-07-20 | |
| 7WU3 | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 10.1038/S41586-022-04580-W | 2022-04-27 | |
| 8YKV | SUCR1 | succinate | Succinate | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL5430997
chembl_ligand
pubchem
|
Agonist | 2.5 | Active | 2024-05-29 | ||
| 8J1A | GPR84 | GPR84 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 10.1038/S41467-023-38985-6 | 2023-06-21 | |
| 8JXT | HRH4 | H4 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
histamine
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
gtoplig
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41467-024-46840-5 | 2024-03-20 | |
| 4A4M | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Stable_cells | HEK293T | Mammalian | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 3 chems | 4.5-4.5 | 4°C |
Retinal (all-trans)
pubchem
|
Agonist | 3.3 | Active | 10.1073/PNAS.1114089108 | 2012-01-25 | ||
| 5WKT | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drop | 4 chems | 5.5-5.5 | 7-10°C |
B-Octylglucoside
pubchem
|
unknown | 3.2 | Active | 10.1038/NPROT.2017.135 | 2017-12-13 | ||
| 5WIV | DRD4 | D4 | Dopamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.9-6.2 | 20°C |
[3H]NEMONAPRIDE
chembl_ligand
pubchem
|
Antagonist | 2.1 | Inactive | 10.1126/SCIENCE.AAN5468 | 2017-10-18 | |
| 6PT3 | OPRD | δ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
DPI-287
pubchem
|
Agonist | 3.3 | Active | 10.1126/SCIADV.AAX9115 | 2019-12-11 | |
| 8YUU | HRH3 | H3 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
histamine
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
gtoplig
pubchem
|
Agonist | 2.7 | Active | 10.1002/ADVS.202310120 | 2024-06-05 | |
| 4LDE | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | 7.7 MAG | 5 chems | 6.5-6.5 | 20°C |
CHEMBL1615159
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1038/NATURE12572 | 2013-09-25 | |
| 8UNS | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8HA0 | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
teriparatide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
pubchem
pubchem
pubchem
pubchem
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41401-022-01032-Z | 2022-12-21 | |
| 8JWY | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL5440290
chembl_ligand
pubchem
|
Antagonist | 2.3 | Inactive | 2023-08-16 | ||
| 7VIF | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(S)-FTY720-phosphate
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.8 | Active | 10.1073/PNAS.2117716119 | 2022-09-28 | |
| 8HMP | GPR52 | GPR52 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
derivative 17 [Nakah...
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.8 | Active | 10.1002/MCO2.260 | 2023-06-21 | |
| 7WC8 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LUMATEPERONE
chembl_ligand
chembl_ligand
pubchem
drugbank
pubchem
|
Agonist | 2.5 | Inactive | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | |
| 7Y89 | GPR17 | GPR17 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.0 | Active | 10.1002/MCO2.159 | 2022-10-12 | |
| 5GLI | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.3-6.3 | 20°C |
Apo (no ligand)
|
Apo (no ligand) | 2.5 | Inactive | 10.1038/nature19319 | 2016-09-07 | |
| 6KP6 | ACM4 | M4 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.0 | Inactive | 10.1107/S2052252520000597 | 2020-03-11 | |
| 7U2K | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL147044
chembl_ligand
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-022-05588-Y | 2022-12-07 | |
| 7R0C | V2R | V2 | Vasopressin and oxytocin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
vasopressin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 4.7 | Active | 10.1126/SCIADV.ABO7761 | 2022-09-14 | |
| 7T2G | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL58362
chembl_ligand
pubchem
|
Agonist | 2.5 | Active | 10.1038/S41589-022-01208-Y | 2022-12-07 | |
| 7CX4 | PE2R2 | EP2 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
evatanepag
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.9 | Active | 10.1126/SCIADV.ABF1268 | 2021-05-05 | |
| 7T6S | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-(4-chlorophenyl)-N...
pubchem
|
Agonist | 3.0 | Active | 2022-03-30 | ||
| 8SZG | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
cinacalcet
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem |
PAMAgonist | 3.6 | Active | 10.1038/S41586-024-07055-2 | 2024-02-07 | |
| 7F1R | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCL5
gtoplig
|
Agonist | 3.0 | Active | 2021-07-14 | ||
| 8WDT | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2S,3S,4R,5R)-5-(6-a...
pubchem
|
Agonist | 3.3 | Active | 10.1016/J.BBRC.2023.149393 | 2024-01-17 | |
| 7YU4 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2~{R})-2-[5-(2-hex...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41467-022-33121-2 | 2022-10-05 | |
| 5UNG | AGTR2 | AT2 | Angiotensin | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 8.0-8.0 | 20°C |
compound 1 [PMID: 28...
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.8 | Active | 10.1038/NATURE22035 | 2017-04-05 | |
| 5ZK3 | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL558910
chembl_ligand
pubchem
|
Antagonist | 2.6 | Inactive | 10.1038/S41589-018-0152-Y | 2018-11-21 | |
| 8W89 | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-Phenylethanaminium
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41586-023-06775-1 | 2023-11-22 | |
| 7TMW | RXFP1 | RXFP1 | Relaxin family peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
H2 relaxin
pubchem
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 2023-02-15 | ||
| 8GE5 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7T9M | TSHR | TSH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CS-17 light chain
CS-17 heavy chain |
Inverse agonistInverse agonist | 3.1 | Inactive | 10.1038/S41586-022-05159-1 | 2022-08-10 | |
| 7EJ8 | ADA2A | α2A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
brimonidine (UK14304...
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 3.0 | Active | 10.1126/SCIADV.ABJ5347 | 2022-04-13 | |
| 6OL9 | ACM5 | M5 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
tiotropium
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
chembl_ligand
chembl_ligand
pubchem
|
Inverse agonist | 2.5 | Inactive | 10.1073/PNAS.1914446116 | 2019-12-11 | |
| 5X93 | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C |
K-8794
pubchem
gtoplig
|
Antagonist | 2.2 | Inactive | 10.1038/NSMB.3450 | 2017-08-16 | |
| 7VLA | CCR1 | CCR1 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCL15(27-92)
|
Agonist | 2.7 | Active | 10.1038/S41589-021-00918-Z | 2022-03-23 | |
| 6A94 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
zotepine
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Antagonist | 2.9 | Inactive | 10.1038/S41594-018-0180-Z | 2019-02-13 | |
| 7UL3 | HRH2 | H2 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
famotidine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/S41594-022-00859-8 | 2022-06-29 | |
| 7XMS | SSR4 | SST4 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SOMATOSTATIN
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41422-022-00679-X | 2022-08-03 | |
| 8HVI | GP132 | GPR132 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
NOX-6-7
pubchem
gtoplig
|
Agonist | 3.0 | Active | 10.1038/S42255-023-00899-4 | 2023-10-11 | |
| 7YU8 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2~{R})-2-[5-(2-hex...
pubchem
|
Agonist | 4.5 | Active | 10.1038/S41467-022-33121-2 | 2022-10-05 | |
| 7MTA | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (all-trans)
pubchem
|
Agonist | 4.1 | Active | 10.1038/S41586-021-03721-X | 2021-07-07 | |
| 5YWY | PE2R4 | EP4 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ONO-AE3-208
pubchem
|
Antagonist | 3.2 | Inactive | 10.1038/S41589-018-0131-3 | 2018-12-05 | |
| 8UNL | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7L1V | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 1 [PMID: 33...
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 10.1038/S41467-021-21087-6 | 2021-02-10 | |
| 7Y67 | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
C089
|
Agonist | 2.8 | Active | 10.1038/S41422-023-00779-2 | 2023-03-01 | |
| 8JLJ | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1182312
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41586-023-06804-Z | 2023-11-15 | |
| 7MT8 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (all-trans)
pubchem
|
Agonist | 5.8 | Active | 10.1038/S41586-021-03721-X | 2021-07-07 | |
| 8IA2 | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
C5a
gtoplig
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2023.09.020 | 2023-10-18 | |
| 8XBH | GPR34 | GPR34 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4758243
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 2023-12-27 | ||
| 7XOX | GASR | CCK2 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCK-8
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 3.1 | Active | 10.1038/S41421-022-00420-3 | 2022-07-20 | |
| 7T94 | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
acetylcholine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
LY2119620 pubchem gtoplig chembl_ligand |
AgonistPAM | 3.2 | Active | 2023-01-25 | ||
| 7D76 | AGRG3 | ADGRG3 | ADGRG | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Beclomethasone
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41586-020-03083-W | 2021-02-03 | |
| 4BVN | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 7.0-7.0 | 22°C |
(S)-Cyanopindolol
pubchem
|
Antagonist | 2.1 | Inactive | 10.1371/JOURNAL.PONE.0092727 | 2014-04-02 | |
| 7YM8 | ADA1A | α1A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
oxymetazoline
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41467-023-39310-X | 2023-07-05 | |
| 6PEL | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Citronellol
pubchem
|
unknown | 3.2 | Active | 2020-06-24 | ||
| 8JD0 | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3894759
chembl_ligand
pubchem
L-glutamic acid pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem |
NAMAgonist | 3.3 | Inactive | 10.1038/S41422-023-00830-2 | 2023-06-21 | |
| 5L7I | SMO | SMO | Frizzled | F (Frizzled) | Human | Transient_transfection | HEK293S(TetR)-GnTI- | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 8 chems | 6.0-6.0 | 20°C |
vismodegib
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 3.3 | Inactive | 10.1038/NATURE18934 | 2016-07-20 | |
| 8UHB | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3684869
chembl_ligand
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41467-023-44601-4 | 2024-01-10 | |
| 7VIH | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
icanbelimod
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 10.1073/PNAS.2117716119 | 2022-09-28 | |
| 8IJ3 | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.3 | Active | 10.1038/S41421-023-00610-7 | 2024-01-03 | |
| 5NDZ | PAR2 | PAR2 | Proteinase-activated | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-6.2 | 20°C |
AZ3451
pubchem
gtoplig
chembl_ligand
|
Allosteric antagonist | 3.6 | Active | 2017-05-03 | ||
| 7WV9 | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
6-methyl-3-[(1S)-2-n...
pubchem
CP55940 pubchem gtoplig chembl_ligand gtoplig |
PAMAgonist | 3.4 | Active | 10.1038/S41589-022-01038-Y | 2022-06-15 | |
| 9IZF | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lysophosphatidic aci...
pubchem
|
Agonist | 3.1 | Active | 2025-01-01 | ||
| 8JGG | MRGX1 | MRGPRX1 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
bovine adrenal medul...
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41467-023-40705-Z | 2024-01-10 | |
| 7Y27 | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SOMATOSTATIN
chembl_ligand
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41589-022-01130-3 | 2022-10-19 | |
| 5NDD | PAR2 | PAR2 | Proteinase-activated | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-6.2 | 20°C |
AZ8838
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.8 | Active | 10.1038/NATURE22309 | 2017-05-03 | |
| 4GPO | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 3.6-4.0 | 18°C |
Apo (no ligand)
|
Apo (no ligand) | 3.5 | Inactive | 10.1038/NSMB.2504 | 2013-02-27 | ||
| 8JR9 | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PCO371
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.6 | Active | 10.1038/S41586-023-06467-W | 2023-08-02 | |
| 8EIT | FFAR1 | FFA1 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
docosahexaenoic acid
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Agonist | 2.8 | Active | 10.1073/PNAS.2219569120 | 2023-05-24 | |
| 6XBM | SMO | SMO | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
24,25-Epoxy-choleste...
pubchem
24,25-Epoxy-choleste... pubchem |
PAMAgonist | 3.2 | Active | 10.1038/S41589-020-0646-2 | 2020-09-30 | |
| 6WW2 | FZD5 | FZD5 | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.7 | Inactive | 10.7554/ELIFE.58464 | 2020-08-19 | |
| 6DRY | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
methylergonovine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.9 | Intermediate | 10.1038/s41594-018-0116-7 | 2018-08-29 | |
| 3OE9 | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.0-6.0 | 20°C |
isothiourea-1t
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.1 | Inactive | 10.1126/SCIENCE.1194396 | 2010-10-27 | |
| 8J9N | FZD1 | FZD1 | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.5 | Active | 10.1038/S41421-023-00627-Y | 2024-01-17 | |
| 7VUJ | GP139 | GPR139 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JNJ-63533054
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.8 | Active | 10.1038/S41422-021-00591-W | 2021-12-29 | |
| 7W3Z | GRPR | BB2 | Bombesin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Gastrin-releasing pe...
pubchem
|
Agonist | 3.0 | Active | 2023-02-22 | ||
| 8WP1 | SUCR1 | succinate | Succinate | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
<i>cis</i>-epoxysucc...
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.2 | Active | 10.1016/J.CELREP.2024.114381 | 2024-09-11 | |
| 8FLU | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PTH
|
Agonist | 2.8 | Active | 10.1016/J.STR.2023.04.002 | 2023-04-26 | |
| 8IRU | DRD4 | D4 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
rotigotine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41422-023-00808-0 | 2023-06-21 | |
| 9IIW | T2R14 | TAS2R14 | Taste 2 | T2 (Taste 2) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 28.1 [PMID:...
pubchem
gtoplig
chembl_ligand
compound 28.1 [PMID:... pubchem gtoplig chembl_ligand |
Allosteric agonistAgonist | 3.2 | Inactive | 2024-07-24 | ||
| 8P12 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 2024-11-20 | ||
| 9K1C | FFAR1 | FFA1 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
docosahexaenoic acid
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELREP.2024.115024 | 2024-12-11 | |
| 6AKX | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4238063
chembl_ligand
pubchem
|
Antagonist | 2.8 | Inactive | 10.1021/acs.jmedchem.8b01077 | 2018-10-24 | |
| 6PS2 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1160734
chembl_ligand
pubchem
|
Antagonist | 2.4 | Inactive | 10.1107/S2052252519013137 | 2019-11-13 | |
| 6FKB | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
2-(4-Chlorophenyl)-1...
pubchem
|
Agonist | 3.0 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
| 8YN3 | HRH2 | H2 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
histamine
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
gtoplig
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41467-024-52585-Y | 2024-10-09 | |
| 8JJO | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1160734
chembl_ligand
pubchem
|
Antagonist | 3.4 | Inactive | 10.1038/S41589-023-01389-0 | 2023-09-06 | |
| 8QOT | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Nanobody-E
|
Antagonist | 3.2 | Inactive | 10.1101/2023.12.06.570395 | 2023-12-27 | |
| 7WC5 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
psilocin
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.2 | Inactive | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | |
| 5ZKQ | PTAFR | PAF | Platelet-activating factor | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ABT-491
pubchem
gtoplig
chembl_ligand
|
Inverse agonist | 2.9 | Active | 2018-06-20 | ||
| 8WVV | LGR4 | LGR4 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.4 | Inactive | 2024-10-30 | ||
| 3OE0 | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
CVX15
|
Antagonist | 2.9 | Inactive | 2010-10-27 | ||
| 7TYN | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
calcitonin (salmon s...
pubchem
chembl_ligand
pubchem
pubchem
|
Agonist | 2.6 | Active | 10.1126/SCIENCE.ABM9609 | 2022-03-30 | |
| 8DPI | 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lorcaserin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.4 | Active | 10.1016/J.CELREP.2022.111211 | 2022-08-24 | |
| 8FLR | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PTHrP[1-36]
|
Agonist | 2.9 | Active | 10.1016/J.STR.2023.04.002 | 2023-04-26 | |
| 8WOG | SUCR1 | succinate | Succinate | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
succinic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.CELREP.2024.114381 | 2024-09-11 | |
| 6XOX | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
orforglipron
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
|
Agonist | 3.1 | Active | 10.1073/PNAS.2014879117 | 2020-11-18 | |
| 5WQC | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 9 chemicals | 9 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 4 chems | 5.8-6.2 | 20°C |
EMPA
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.0 | Inactive | 10.1016/J.STR.2017.11.005 | 2017-11-29 | |
| 8IUK | PF2R | FP | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PGF<sub>2α</su...
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 2.7 | Active | 10.1038/S41467-023-38411-X | 2023-07-12 | |
| 7XT9 | 5HT4R | 5-HT4 | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-hydroxytryptamine
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.2 | Active | 10.1016/J.MOLCEL.2022.05.031 | 2022-07-27 | |
| 9BQJ | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-[[3-(hydroxymethyl...
pubchem
|
Agonist | 3.3 | Active | 2024-09-11 | ||
| 6D9H | AA1R | A1 | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | Cryo-EM | Volta phase plate(FEI), FEI Titan Krios@300kV, Gatan K2 Summit direct electron camera , Gatan Quantum energy filter | 6 chems | 7.4-7.4 | 4°C |
adenosine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.6 | Active | 10.1038/S41586-018-0236-6 | 2018-06-20 | ||
| 8WM9 | FZD4 | FZD4 | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.5 | Active | 10.1038/S41467-024-52174-Z | 2024-09-11 | |
| 5DYS | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Stable_cells | HEK293S-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Sitting drop | 4 chems | 4.5-4.5 | 20°C |
Retinal (all-trans)
pubchem
|
Agonist | 2.3 | Active | 2016-08-10 | |||
| 8JJ8 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ARFORMOTEROL
chembl_ligand
chembl_ligand
chembl_ligand
chembl_ligand
pubchem
drugbank
drugbank
pubchem
|
Agonist (partial) | 3.2 | Active | 10.1038/S41589-023-01389-0 | 2023-09-06 | |
| 7XJK | GALR2 | GAL2 | Galanin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Galanin, Human
pubchem
|
Agonist | 3.3 | Active | 10.1073/PNAS.2121465119 | 2022-06-29 | |
| 4BEZ | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Stable_cells | HEK293S-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 4 chems | 4.5-4.5 | 20°C |
Apo (no ligand)
|
Apo (no ligand) | 3.3 | Active | 10.1038/EMBOR.2013.44 | 2013-04-24 | ||
| 8XFP | LGR4 | LGR4 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
R-spondin-2
|
Agonist | 3.2 | Inactive | 2024-12-04 | ||
| 9JR2 | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Parathyroid hormone
pubchem
|
Agonist | 2.8 | Active | 2024-10-16 | ||
| 8IU2 | OPSR | OPN1LW | Opsins | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (11-cis)
pubchem
|
Agonist | 3.4 | Active | 2024-03-27 | ||
| 6PS6 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
timolol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 2.7 | Inactive | 10.1107/S2052252519013137 | 2019-11-13 | |
| 8FCZ | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (11-cis)
pubchem
|
Inverse agonist | 3.7 | Inactive | 10.1038/S41467-023-40911-9 | 2023-08-30 | |
| 9J5V | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CpY
pubchem
gtoplig
|
Agonist | 2.9 | Active | 2024-11-27 | ||
| 8X0F | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
VU-29
pubchem
gtoplig
chembl_ligand
quisqualate pubchem gtoplig chembl_ligand drugbank gtoplig pubchem |
PAMAgonist | 3.3 | Active | 10.1038/S41467-024-55439-9 | 2024-11-06 | |
| 7EW4 | S1PR3 | S1P3 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CYM-5541
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.2 | Active | 10.1038/S41422-021-00567-W | 2021-09-29 | |
| 7F1O | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dopamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.1 | Active | 10.1126/SCIADV.ABO4158 | 2022-06-15 | |
| 4XNW | P2RY1 | P2Y1 | P2Y | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-8.0 | 20°C |
MRS2500
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.7 | Active | 10.1038/NATURE14287 | 2015-04-01 | |
| 7W2Z | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Ghrelin
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-022-27975-9 | 2022-01-19 | |
| 5W0P | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Human | Transient_transfection | HEK293S(TetR- GnTI- | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monopalmitolein (9.7 MAG) | 5 chems | 5.0-5.0 | 20°C |
Apo (no ligand)
|
Apo (no ligand) | 3.0 | Active | 10.1016/J.CELL.2017.07.002 | 2017-08-09 | |
| 7M3F | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
cinacalcet
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem Calcium pubchem |
PAMPAMAgonist | 2.8 | Active | 10.1038/S41586-021-03691-0 | 2021-06-30 | |
| 7XTQ | GPBAR | GPBA | Bile acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL2181246
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1073/PNAS.2117054119 | 2022-07-06 | |
| 7EO4 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
siponimod
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41589-021-00930-3 | 2022-01-05 | |
| 7F4H | MSHR | MC1 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL407070
chembl_ligand
pubchem
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41422-021-00557-Y | 2021-09-08 | |
| 4ZUD | AGTR1 | AT1 | Angiotensin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-5.0 | 20°C |
OLMESARTAN
chembl_ligand
pubchem
|
Inverse agonist | 2.8 | Inactive | 10.1074/JBC.M115.689000 | 2015-10-07 | |
| 5U09 | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 9 chemicals | 9 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20°C |
taranabant
pubchem
gtoplig
chembl_ligand
drugbank
|
Inverse agonist | 2.6 | Inactive | 10.1038/NATURE20613 | 2016-12-07 | |
| 8I9L | C3AR | C3a | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
C3a anaphylatoxin
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2023.09.020 | 2023-10-18 | |
| 8IKJ | AGRE5 | ADGRE5 | ADGRE | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Inactive | 10.1016/J.MOLCEL.2023.12.020 | 2024-02-14 | |
| 8ITF | TAAR9 | TAAR9 | A orphans | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N,N-Dimethylcyclohex...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-023-06106-4 | 2023-05-31 | |
| 5ZKP | PTAFR | PAF | Platelet-activating factor | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
foropafant
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.8 | Other | 10.1038/S41594-018-0068-Y | 2018-06-20 | |
| 6TP6 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
filorexant
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.3 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
| 7ZL9 | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.7 | Active | 10.1038/S41467-023-37177-6 | 2023-04-12 | |
| 5OLZ | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
CHEMBL2024114
chembl_ligand
pubchem
|
Antagonist | 1.9 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
| 6S0L | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.7 | Inactive | 10.1107/S2052252520011379 | 2020-07-15 | |
| 9C2F | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(1R)-1-(2H-1,3-benzo...
pubchem
|
PAM | 2.8 | Inactive | 2024-10-02 | ||
| 7L1U | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Orexin-A
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41467-021-21087-6 | 2021-02-10 | |
| 2YDO | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 4 chemicals | 4 steps | vapour diffusion | sitting drop | 5 chems | 7.6-7.6 | 4°C |
adenosine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.0 | Active | 2011-05-18 | |||
| 8PKM | 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2r)-1-(Heptadecanoy...
pubchem
BEFIRADOL chembl_ligand pubchem pubchem |
PAMAgonist | 2.9 | Active | 2024-05-29 | ||
| 7E14 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
orforglipron
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
N-Tert-butyl-6,7-dic... pubchem |
AgonistAgo-PAM | 2.9 | Active | 10.1038/S41467-021-24058-Z | 2021-07-07 | |
| 7YXA | S1PR5 | S1P5 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
4-[6-(2-naphthalen-1...
pubchem
|
Antagonist | 2.2 | Inactive | 10.1038/S41467-022-32447-1 | 2022-08-10 | |
| 7SR8 | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
methyl (2R,3S)-3-[(m...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41467-022-30601-3 | 2022-06-08 | |
| 8GG9 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 6FFI | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-6.8 | 20°C |
methoxy-MPEP
pubchem
gtoplig
chembl_ligand
gtoplig
|
NAM | 2.2 | Inactive | 2018-03-07 | ||
| 8GTG | CRFR1 | CRF1 | Corticotropin-releasing factor | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
8-(4-bromo-2,6-dimet...
pubchem
|
Antagonist | 2.8 | Inactive | 10.1038/S12276-023-01082-1 | 2023-09-13 | |
| 7XK2 | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MK 6892
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41467-023-37177-6 | 2023-02-22 | |
| 6OS1 | AGTR1 | AT1 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
TRV023
|
Agonist | 2.8 | Active | 10.1126/SCIENCE.AAY9813 | 2020-02-19 | |
| 5K2A | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.5 | Inactive | 10.1126/SCIADV.1600292 | 2016-09-21 | |
| 5VBL | APJ | apelin | Apelin | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 6.1-6.1 | 20-22°C |
AMG3054
gtoplig
|
Agonist | 2.6 | Inactive | 10.1016/J.STR.2017.04.008 | 2017-05-31 | |
| 8SZH | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
cinacalcet
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem |
PAMAgonist | 3.1 | Active | 10.1038/S41586-024-07055-2 | 2024-02-07 | |
| 8HJ1 | GPR21 | GPR21 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.3 | Active | 10.1038/S41467-023-35882-W | 2023-12-27 | |
| 6OBA | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1160734
chembl_ligand
pubchem
AS408 pubchem gtoplig chembl_ligand |
AntagonistNAM | 3.1 | Inactive | 10.1038/S41589-020-0549-2 | 2020-03-25 | |
| 8U1U | CCR8 | CCR8 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCL1
|
Agonist | 3.1 | Active | 2023-12-20 | ||
| 7LLL | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
exendin-4
pubchem
gtoplig
pubchem
|
Agonist | 3.7 | Active | 10.1038/S41467-021-27760-0 | 2022-01-12 | |
| 7WVU | FPR1 | FPR1 | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
FME-LEU-PHE
|
Agonist | 3.3 | Active | 10.1038/S41467-022-29361-X | 2022-04-13 | |
| 6LPK | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.8 | Inactive | 2020-11-25 | ||
| 8WKY | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-(2-aminoethyl)-5-(...
|
Antagonist | 2.9 | Intermediate | 10.1021/ACS.JMEDCHEM.3C01822 | 2024-08-07 | |
| 7RTB | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Peptide-19
|
Agonist | 2.1 | Active | 10.1016/J.BBRC.2021.09.016 | 2021-10-06 | |
| 4PY0 | P2Y12 | P2Y12 | P2Y | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-6.0 | 20°C |
2MeSATP
pubchem
gtoplig
chembl_ligand
|
Agonist (partial) | 3.1 | Active | 2014-04-30 | ||
| 9D3G | CCR6 | CCR6 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
4-[[3,4-Dioxo-2-[[(1...
pubchem
1-(4-chlorophenyl)-N... pubchem |
NAMAntagonist | 3.3 | Inactive | 2024-09-11 | ||
| 6LFO | CXCR2 | CXCR2 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Interleukin-8
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-020-2492-5 | 2020-09-02 | |
| 8FYX | 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
buspirone
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41586-024-07403-2 | 2024-05-15 | |
| 5IUA | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20 |
2-(Furan-2-yl)-5-N-[...
pubchem
|
Antagonist | 2.2 | Inactive | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | |
| 7DTW | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 4.5 | Inactive | 10.1038/S41422-021-00474-0 | 2021-03-10 | |
| 7X9C | NPY4R | Y4 | Neuropeptide Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Pancreatic polypepti...
pubchem
|
Agonist | 3.0 | Active | 10.1126/SCIADV.ABM1232 | 2022-05-18 | |
| 8F7W | OPRK | κ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dynorphin A-(1-8)
pubchem
gtoplig
chembl_ligand
pubchem
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | |
| 6J21 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
aprepitant
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 3.2 | Inactive | 10.1038/S41467-019-08568-5 | 2019-03-06 | |
| 9DQJ | MRGRD | MRGPRD | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-[[1-[1-(4-methoxyp...
pubchem
|
Agonist | 2.9 | Active | 2024-12-11 | ||
| 7XKE | AGRG2 | ADGRG2 | ADGRG | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PRASTERONE
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41589-022-01084-6 | 2022-08-10 | |
| 6KUW | ADA2C | α2C | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(8Ar,12aS,13aR)-12-e...
pubchem
|
Antagonist | 2.8 | Inactive | 2019-12-04 | ||
| 7X2F | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dopamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
mevidalen pubchem gtoplig chembl_ligand pubchem |
AgonistPAM | 3.0 | Active | 10.1038/S41467-022-30929-W | 2022-06-15 | |
| 6I9K | B1B1U5 | Rhodopsin | Opsins | A (Rhodopsin) | Hasarius adansoni | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (11-cis)
pubchem
|
Inverse agonist | 2.2 | Inactive | 10.1073/PNAS.1902192116 | 2019-07-03 | |
| 8JXR | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Lysergide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.6 | Active | 10.1016/J.NEURON.2024.07.003 | 2024-09-04 | |
| 6O3C | SMO | SMO | Frizzled | F (Frizzled) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SAG21k
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41586-019-1355-4 | 2019-07-03 | |
| 8I2H | FSHR | FSH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 6.0 | Inactive | 10.1038/S41467-023-36170-3 | 2023-03-22 | |
| 3AYN | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Japanese flying squid | NA | Native | Squid | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 5 chems | 6.0-6.0 | 4°C |
Retinal (9-cis)
pubchem
|
Inverse agonist | 2.7 | Inactive | 10.1016/J.JMB.2011.08.044 | 2011-08-17 | ||
| 8UXV | O51G2 | OR51G2 | Odorant family 51 | O1 (fish-like odorant) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 10.1038/S41586-024-08126-0 | 2024-10-30 | |
| 9BKK | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL216166
chembl_ligand
pubchem
|
Agonist | 2.5 | Active | 10.1371/JOURNAL.PBIO.3002673 | 2024-05-22 | |
| 8U4R | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
REGN7663 Fab heavy c...
|
Agonist | 3.1 | Inactive | 10.1038/S41594-024-01397-1 | 2024-03-13 | |
| 9CBM | ADA2A | α2A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dexmedetomidine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.2 | Active | 10.1038/S12276-024-01296-X | 2024-09-11 | |
| 8KEX | MRGX4 | MRGPRX4 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
DCA-3P
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2024.10.001 | 2024-11-06 | |
| 8I9S | C3AR | C3a | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.3 | Active | 10.1016/J.CELL.2023.09.020 | 2023-10-18 | |
| 7AUE | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
setmelanotide
pubchem
gtoplig
drug_central
chembl_ligand
drugbank
pubchem
|
Agonist | 3.0 | Active | 10.1126/SCIENCE.ABF7958 | 2021-04-28 | |
| 9BA0 | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Monlunabant
pubchem
|
Inverse agonist | 3.1 | Inactive | 2024-11-20 | ||
| 4XNV | P2RY1 | P2Y1 | P2Y | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.5-6.5 | 20°C |
BMS compound 16 [PMI...
pubchem
gtoplig
chembl_ligand
|
NAM | 2.2 | Active | 10.1038/NATURE14287 | 2015-04-01 | |
| 5IU8 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20°C |
CHEMBL3934661
chembl_ligand
pubchem
|
Antagonist | 2.0 | Inactive | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | |
| 8T3V | FFAR1 | FFA1 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
docosahexaenoic acid
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Agonist | 3.4 | Active | 10.1126/SCIADV.ADJ2384 | 2024-01-24 | |
| 7Y64 | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
C5a anaphylatoxin
|
Agonist | 2.9 | Active | 10.1038/S41422-023-00779-2 | 2023-03-01 | |
| 7Y13 | MRGRD | MRGPRD | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Intermediate | 10.1038/S42003-022-03668-3 | 2022-07-20 | |
| 7D77 | AGRG3 | ADGRG3 | ADGRG | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
HYDROCORTISONE
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41586-020-03083-W | 2021-02-03 | |
| 8F2B | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Pramlintide analogue...
|
Agonist | 2.0 | Active | 10.1038/S41589-023-01393-4 | 2023-08-02 | |
| 8WC5 | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Tetramethylammonium
chembl_ligand
pubchem
|
Agonist | 3.3 | Active | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | |
| 8GNG | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
istradefylline
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Antagonist | 3.2 | Inactive | 10.1124/MOLPHARM.122.000633 | 2023-03-22 | |
| 6E67 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1615159
chembl_ligand
pubchem
|
Agonist | 3.7 | Active | 10.1016/J.CELL.2019.04.021 | 2019-06-05 | |
| 4AMJ | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | sitting drops | 3 chems | 9.0-9.0 | 4°C |
CHEMBL3799125
chembl_ligand
pubchem
|
Inverse agonist | 2.3 | Inactive | 10.1016/J.STR.2012.03.014 | 2012-05-23 | ||
| 7F6H | BKRB2 | B2 | Bradykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
bradykinin
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
|
Agonist | 2.9 | Active | 10.1038/S41467-022-28399-1 | 2022-01-05 | |
| 7BZ2 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ARFORMOTEROL
chembl_ligand
chembl_ligand
chembl_ligand
chembl_ligand
pubchem
drugbank
drugbank
pubchem
|
Agonist | 3.8 | Active | 10.1038/S41421-020-0176-9 | 2020-08-05 | |
| 9CHU | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Noradrenaline
pubchem
|
Agonist | 3.5 | Intermediate | 10.1073/PNAS.2414544121 | 2024-11-13 | |
| 6H7M | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
levosalbutamol
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Agonist | 2.8 | Active | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | |
| 7F1S | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 10.1038/S41467-021-24438-5 | 2021-07-14 | |
| 8WCA | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-Phenylethanaminium
pubchem
|
Agonist | 3.5 | Active | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | |
| 8JSO | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dexamfetamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.4 | Active | 10.1038/S41586-023-06804-Z | 2023-11-15 | |
| 7XY7 | AA2BR | A2B | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
NECA
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 3.3 | Active | 10.1126/SCIADV.ADD3709 | 2023-05-03 | |
| 6OSA | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JMV449
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 10.1038/S41586-019-1337-6 | 2019-07-10 | |
| 7EJA | ADA2A | α2A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dexmedetomidine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.6 | Active | 10.1126/SCIADV.ABJ5347 | 2022-04-13 | |
| 7CX2 | PE2R2 | EP2 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PGE2
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 2.8 | Active | 10.1126/SCIADV.ABF1268 | 2021-05-05 | |
| 4Z9G | CRFR1 | CRF1 | Corticotropin-releasing factor | B1 (Secretin) | Human | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-5.5 | 23°C |
CP 376,395
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.2 | Inactive | 10.2174/1874467210666170110114727 | 2016-06-29 | |
| 8X0G | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
quisqualate
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41467-024-55439-9 | 2024-11-06 | |
| 5OLO | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
tozadenant
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 3.1 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
| 8GGE | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7CMU | DRD3 | D3 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
pramipexole
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.MOLCEL.2021.01.003 | 2021-03-10 | |
| 2Y00 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 6 chems | 8.5-8.5 | 4°C |
Dobutamine
pubchem
|
Agonist (partial) | 2.5 | Inactive | 10.1038/NATURE09746 | 2011-01-12 | ||
| 8IHB | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
GSK256073
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.9 | Active | 10.1038/S41467-023-41650-7 | 2023-09-13 | |
| 6MXT | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
salmeterol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.0 | Active | 10.1038/s41589-018-0145-x | 2018-11-14 | |
| 8VY9 | T2R14 | TAS2R14 | Taste 2 | T2 (Taste 2) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 28.1 [PMID:...
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.9 | Active | 2024-04-03 | ||
| 8TB7 | GPR61 | GPR61 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 1 [PMID: 37...
pubchem
gtoplig
|
Inverse agonist | 2.9 | Active | 10.1038/S41467-023-41646-3 | 2023-10-04 | |
| 7MTS | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-methoxy-6-propyl-N...
pubchem
L-glutamic acid pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem |
Ago-PAMAgonist | 3.2 | Active | 10.1038/S41586-021-03680-3 | 2021-07-07 | |
| 7T6U | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
synthetic peptide
|
Agonist | 2.9 | Active | 10.1038/S41467-022-28586-0 | 2022-03-30 | |
| 8UGY | 5HT1E | 5-HT1E | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL252719
chembl_ligand
pubchem
|
Agonist | 3.3 | Active | 10.1126/SCIADV.ADK4855 | 2024-05-01 | |
| 8W88 | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ulotaront
pubchem
gtoplig
drugbank
chembl_ligand
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41586-023-06775-1 | 2023-11-22 | |
| 8HQE | GP132 | GPR132 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.0 | Active | 10.1038/S42255-023-00899-4 | 2023-10-11 | |
| 8WST | MCHR2 | MCH2 | Melanin-concentrating hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
pro-MCH
|
Agonist | 2.4 | Active | 10.1038/S41421-024-00679-8 | 2024-06-19 | |
| 7CKZ | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dopamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
mevidalen pubchem gtoplig chembl_ligand pubchem |
AgonistPAM | 3.1 | Active | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | |
| 5C1M | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 7.5-7.5 | 20°C |
BU72
pubchem
gtoplig
pubchem
|
Agonist | 2.1 | Active | 10.1038/NATURE14886 | 2015-08-05 | |
| 8SG1 | CML1 | chemerin | Chemerin receptor | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
chemerin C-terminal ...
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 10.1371/JOURNAL.PBIO.3002188 | 2023-11-01 | |
| 8E9Z | ACM3 | M3 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
iperoxo
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.7 | Active | 10.1038/S41586-022-05489-0 | 2022-11-30 | |
| 8XXU | PD2R2 | DP2 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2~{R})-1-hexadecan...
|
PAM | 2.5 | Active | 2024-12-04 | ||
| 6ORV | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3950796
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1038/s41586-019-1902-z | 2020-01-08 | |
| 7SIM | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cyclomethyltryptopha...
pubchem
|
Agonist | 2.7 | Active | 10.1073/PNAS.2115849118 | 2022-01-19 | |
| 6TKO | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ARFORMOTEROL
chembl_ligand
chembl_ligand
chembl_ligand
chembl_ligand
pubchem
drugbank
drugbank
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-020-2419-1 | 2020-06-17 | |
| 8JIQ | GLR | glucagon | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Dual-agonist peptide...
|
Agonist | 3.4 | Active | 2023-09-13 | ||
| 7RMH | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 3.1 | Active | 10.1038/S41589-021-00890-8 | 2021-11-03 | |
| 7DDZ | NPY2R | Y2 | Neuropeptide Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1823578
chembl_ligand
pubchem
|
Antagonist | 2.8 | Inactive | 10.1038/S41467-021-21030-9 | 2021-01-27 | |
| 5UIW | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.3-6.3 | 20°C |
5P7-CCL5
|
Antagonist | 2.2 | Inactive | 10.1016/J.IMMUNI.2017.05.002 | 2017-06-28 | |
| 7VL8 | CCR1 | CCR1 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1038/S41589-021-00918-Z | 2022-03-23 | |
| 8GGI | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8XZH | APJ | apelin | Apelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MM07
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.6 | Active | 10.1016/J.CELL.2024.02.004 | 2024-03-20 | |
| 8JD1 | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-glutamic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
|
Agonist | 3.7 | Inactive | 10.1038/S41422-023-00830-2 | 2023-06-21 | |
| 7TRY | CRFR2 | CRF2 | Corticotropin-releasing factor | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Urocortin
pubchem
|
Agonist | 3.7 | Active | 10.1038/S41467-022-33851-3 | 2022-11-09 | |
| 4EIY | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.8 | Inactive | 10.1126/SCIENCE.1219218 | 2012-07-25 | |
| 8GFW | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8JLK | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ulotaront
pubchem
gtoplig
drugbank
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41586-023-06804-Z | 2023-11-15 | |
| 8GY7 | ACTHR | MC2 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ACTH
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41422-022-00751-6 | 2023-01-11 | |
| 6VCB | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL5197819
chembl_ligand
pubchem
glucagon-like peptid... pubchem gtoplig chembl_ligand gtoplig pubchem pubchem |
PAMAgonist | 3.3 | Active | 10.1038/S41589-020-0589-7 | 2020-07-22 | |
| 4ZJ8 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.4-5.4 | 20°C |
suvorexant
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Antagonist | 2.8 | Inactive | 10.1038/NSMB.3183 | 2016-03-09 | |
| 8ZSV | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
RO5256390
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 2024-07-24 | ||
| 7W0O | APJ | apelin | Apelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apelin receptor earl...
|
Agonist | 3.8 | Active | 10.1038/S41594-022-00797-5 | 2022-07-27 | |
| 7SBF | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-[(2S)-2-(dimethyla...
pubchem
|
Agonist | 2.9 | Active | 10.1002/ANIE.202200269 | 2022-04-20 | |
| 7DFL | HRH1 | H1 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
histamine
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
gtoplig
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41467-021-22427-2 | 2021-03-31 | |
| 8J6P | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
nicotinic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41467-023-43537-Z | 2023-12-06 | |
| 7TYY | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
calcitonin (salmon s...
pubchem
chembl_ligand
pubchem
pubchem
|
Agonist | 3.0 | Active | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | |
| 7XOV | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SR146131
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 10.1038/S41421-022-00420-3 | 2022-07-20 | |
| 7F0T | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dopamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.1 | Active | 10.1126/SCIADV.ABO4158 | 2022-06-15 | |
| 8JMT | AGRL3 | ADGRL3 | ADGRL | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.3 | Inactive | 10.1038/S41589-023-01389-0 | 2023-09-06 | |
| 7XV3 | GP174 | GPR174 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2~{S})-2-$l^{4}-aza...
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-023-36575-0 | 2023-02-15 | |
| 7XN9 | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-054,522
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.6 | Inactive | 10.1038/S41422-022-00679-X | 2022-08-03 | |
| 4XT1 | US28 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 6.3-7.0 | 20°C |
CX3CL1
gtoplig
|
Agonist (partial) | 2.9 | Active | 10.1126/SCIENCE.AAA5026 | 2015-03-04 | |
| 8F76 | O51E2 | OR51E2 | Odorant family 51 | O1 (fish-like odorant) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
propanoic acid
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.1 | Active | 10.1038/S41586-023-05798-Y | 2023-03-22 | |
| 7EPT | AGRD1 | ADGRD1 | ADGRD | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.0 | Active | 10.1038/S41586-022-04619-Y | 2022-05-11 | |
| 8GGV | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8IW1 | TAAR9 | TAAR9 | A orphans | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-Phenylethanaminium
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-023-06106-4 | 2023-05-31 | |
| 8JCW | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 3.0 | Inactive | 10.1038/S41422-023-00830-2 | 2023-06-21 | |
| 7WC4 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-hydroxytryptamine
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.2 | Inactive | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | |
| 8JPB | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4576388
chembl_ligand
pubchem
JMV431 gtoplig chembl_ligand pubchem |
PAMAgonist | 3.1 | Active | 10.1038/S41586-023-06395-9 | 2023-08-09 | |
| 8K4N | GPR34 | GPR34 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2R)-2-azanyl-3-[oxi...
pubchem
|
Agonist | 2.8 | Active | 2023-10-25 | ||
| 7T6B | S1PR2 | S1P2 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
sphingosine 1-phosph...
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1126/SCIADV.ABN0067 | 2022-04-06 | |
| 7WQ4 | GALR2 | GAL2 | Galanin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
galanin
pubchem
gtoplig
chembl_ligand
gtoplig
pubchem
pubchem
pubchem
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41467-022-29072-3 | 2022-04-20 | |
| 6FK6 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
COMPOUND SUMMARY
pubchem
|
Agonist | 2.4 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
| 8FD0 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.7 | Inactive | 10.1038/S41467-023-40911-9 | 2023-08-30 | |
| 7DHI | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
levosalbutamol
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Agonist | 3.3 | Active | 10.1093/NSR/NWAA284 | 2020-12-16 | |
| 8FEG | OPRK | κ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ACE-TYR-ALA-DTY-THR-...
|
Agonist | 2.5 | Active | 10.1038/s41467-023-43718-w | 2023-12-06 | |
| 7LJD | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dopamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
mevidalen pubchem gtoplig chembl_ligand pubchem |
AgonistPAM | 3.2 | Active | 2021-03-03 | ||
| 8W87 | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
METHAMPHETAMINE
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41586-023-06775-1 | 2023-11-22 | |
| 8GE2 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8WWL | MCHR1 | MCH1 | Melanin-concentrating hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Melanin-concentratin...
|
Agonist | 2.8 | Active | 10.1038/S41421-024-00754-0 | 2024-11-13 | |
| 8T3Q | FFAR4 | FFA4 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
docosahexaenoic acid
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Agonist | 3.1 | Active | 10.1126/SCIADV.ADJ2384 | 2024-01-24 | |
| 6NBI | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Long-acting parathyr...
|
Agonist | 4.0 | Active | 10.1126/SCIENCE.AAV7942 | 2019-04-17 | |
| 8XBG | GPR34 | GPR34 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4782438
chembl_ligand
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41467-024-45046-Z | 2024-05-15 | |
| 8YW3 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retatrutide
|
Agonist | 2.7 | Active | 10.1038/S41421-024-00700-0 | 2024-09-18 | |
| 6PS0 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
carazolol
pubchem
gtoplig
chembl_ligand
drug_central
|
Antagonist | 3.4 | Inactive | 10.1107/S2052252519013137 | 2019-11-13 | |
| 5ZTY | CNR2 | CB2 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AM10257
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.8 | Inactive | 10.1016/J.CELL.2018.12.011 | 2019-01-30 | |
| 7MT9 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (all-trans)
pubchem
|
Agonist | 7.0 | Active | 10.1038/S41586-021-03721-X | 2021-07-07 | |
| 7YAC | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PALTUSOTINE
chembl_ligand
pubchem
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41467-023-36673-Z | 2023-04-19 | |
| 4DAJ | ACM3 | M3 | Acetylcholine (muscarinic) | A (Rhodopsin) | Rat | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.5-7.5 | 22°C |
tiotropium
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
chembl_ligand
chembl_ligand
pubchem
|
Antagonist | 3.4 | Inactive | 10.1038/NATURE10867 | 2012-02-22 | |
| 7EUO | FPR1 | FPR1 | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Peptide Agonist fMLF
|
Agonist | 2.9 | Active | 10.1038/S41467-022-32822-Y | 2022-05-25 | |
| 7F4F | MSHR | MC1 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL407070
chembl_ligand
pubchem
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41422-021-00557-Y | 2021-09-08 | |
| 8SZF | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-tryptophan
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
cinacalcet pubchem gtoplig chembl_ligand drugbank drug_central pubchem |
AgonistPAM | 2.8 | Active | 10.1038/S41586-024-07055-2 | 2024-02-07 | |
| 8WU1 | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MDMB-Fubinaca
pubchem
gtoplig
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2023.11.017 | 2024-03-20 | |
| 7WVX | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
humanin
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-022-29361-X | 2022-04-13 | |
| 8J6J | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
GSK256073
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.8 | Active | 10.1016/J.CELREP.2023.113406 | 2024-01-10 | |
| 5XPR | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C |
bosentan
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 3.6 | Inactive | 10.1038/NSMB.3450 | 2017-08-16 | |
| 6M9T | PE2R3 | EP3 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Misoprostol-FA
pubchem
|
Agonist | 2.5 | Active | 10.1038/S41589-018-0160-Y | 2018-12-05 | |
| 8IBV | MTLR | motilin | Motilin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
motilin
pubchem
gtoplig
chembl_ligand
gtoplig
pubchem
pubchem
|
Agonist | 3.2 | Active | 10.1126/SCIADV.ADE9020 | 2023-04-12 | |
| 8GG2 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 6PS7 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.9 | Inactive | 10.1107/S2052252519013137 | 2019-11-13 | |
| 6D32 | Q98SW5 | SMO | Frizzled | F (Frizzled) | African clawed frog | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.5 | 20°C |
cyclopamine
pubchem
gtoplig
chembl_ligand
|
Agonist (partial) | 3.8 | Active | 10.1016/J.CELL.2018.04.029 | 2018-05-23 | |
| 8FLT | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
M-PTH(1-14)
|
Agonist | 3.0 | Active | 10.1016/J.STR.2023.04.002 | 2023-04-26 | |
| 9DQH | MRGRD | MRGPRD | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-[[1-[2-(4-chloroph...
pubchem
|
Agonist | 2.9 | Active | 2024-12-11 | ||
| 7DFP | DRD2 | D2 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
spiperone
pubchem
gtoplig
chembl_ligand
drug_central
gtoplig
|
Antagonist | 3.1 | Inactive | 10.1038/S41467-020-20221-0 | 2020-12-30 | |
| 6ME4 | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-iodo-melatonin
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.2 | Inactive | 10.1038/S41586-019-1141-3 | 2019-04-24 | |
| 5O9H | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 5.5-6.0 | 22.5°C |
NDT9513727
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.7 | Inactive | 10.1038/NATURE25025 | 2018-01-10 | |
| 6VMS | DRD2 | D2 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
bromocriptine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.8 | Active | 10.1038/S41586-020-2379-5 | 2020-06-17 | |
| 4PHU | FFAR1 | FFA1 | Free fatty acid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.6-7.6 | 20°C |
fasiglifam
pubchem
gtoplig
chembl_ligand
drugbank
|
Allosteric agonist | 2.3 | Active | 10.1038/NATURE13494 | 2014-07-16 | |
| 6WGT | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Lysergide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.4 | Inactive | 10.1016/J.CELL.2020.08.024 | 2020-09-23 | |
| 8XWP | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ENDOTHELIN
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1038/S42003-024-06905-Z | 2024-10-02 | |
| 7DD5 | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-tryptophan
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
NPS 2143 pubchem gtoplig chembl_ligand drugbank Calcium pubchem |
PAMNAMAgonist | 3.2 | Inactive | 10.1126/SCIADV.ABG1483 | 2021-06-16 | |
| 7VGX | NPY1R | Y1 | Neuropeptide Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
neuropeptide Y
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
pubchem
pubchem
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41467-022-28510-6 | 2022-02-23 | |
| 6CM4 | DRD2 | D2 | Dopamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 6 chems | 7.8-7.8 | 20°C |
risperidone
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Inverse agonist | 2.9 | Inactive | 10.1038/NATURE25758 | 2018-03-14 | |
| 6TOD | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
EMPA
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.1 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
| 8A6E | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (11-cis)
pubchem
|
Agonist | 1.8 | Inactive | 10.1038/S41586-023-05863-6 | 2023-03-29 | |
| 6E59 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L760735
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.4 | Inactive | 10.1073/PNAS.1812717115 | 2018-12-12 | |
| 8X79 | PI2R | IP | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MRE-269
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.4 | Active | 10.1126/SCIADV.ADK5184 | 2024-03-06 | |
| 7Y1F | OPRK | κ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dynorphin A-(1-8)
pubchem
gtoplig
chembl_ligand
pubchem
pubchem
|
Agonist | 3.3 | Active | 10.1093/PROCEL/PWAC033 | 2023-05-24 | |
| 5IU7 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
2-(Furan-2-yl)-5-N-[...
pubchem
|
Antagonist | 1.9 | Inactive | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | |
| 4N4W | SMO | SMO | Frizzled | F (Frizzled) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 6.9-6.9 | 20°C |
SANT-1
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.8 | Inactive | 10.1038/NCOMMS5355 | 2014-01-22 | |
| 7DTU | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-tryptophan
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
PAM | 4.4 | Intermediate | 10.1038/S41422-021-00474-0 | 2021-03-10 | |
| 5TZR | FFAR1 | FFA1 | Free fatty acid | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.7-8.3 | 20°C |
MK-8666
chembl_ligand
pubchem
|
Allosteric agonist | 2.2 | Active | 10.1038/NSMB.3417 | 2017-06-07 | |
| 4RWA | OPRD | δ | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.0-6.0 | 20°C |
DIPP-NH2
|
Antagonist | 3.3 | Inactive | 10.1038/NSMB.2965 | 2015-01-14 | |
| 8GEA | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 6ZDR | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL2030687
chembl_ligand
pubchem
|
Antagonist | 1.9 | Inactive | 10.1002/ANIE.202003788 | 2020-09-16 | |
| 7SIL | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cyclomethyltryptopha...
pubchem
tecalcet pubchem gtoplig chembl_ligand |
AgonistAgonist | 2.7 | Active | 10.1073/PNAS.2115849118 | 2022-01-19 | |
| 2ZIY | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Japanese flying squid | NA | Native | Squid | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 7.0-7.0 | 20°C |
Retinal (11-cis)
pubchem
|
Inverse agonist | 3.7 | Inactive | 10.1074/JBC.C800040200 | 2008-05-06 | ||
| 6GPS | CCR2 | CCR2 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MK-0812
pubchem
|
Antagonist | 3.3 | Inactive | 10.1016/J.STR.2018.10.027 | 2019-01-02 | |
| 8H4I | FFAR4 | FFA4 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
docosahexaenoic acid
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41422-023-00835-X | 2023-06-21 | |
| 8IYS | FFAR4 | FFA4 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
TUG-891
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 10.1038/S41422-023-00835-X | 2023-06-21 | |
| 4BV0 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | NA | E. coli BL21(DE3) | Bacteria | 3 chemicals | 3 steps | vapour diffusion | sitting drops | 5 chems | 9.4-9.4 | 4°C |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 3.1 | Inactive | 10.1073/PNAS.1317903111 | 2014-01-29 | ||
| 6LUQ | DRD2 | D2 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
haloperidol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 3.1 | Inactive | 10.1038/S41467-020-14884-Y | 2020-03-04 | |
| 7WY5 | AGRL3 | ADGRL3 | ADGRL | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 10.1016/J.MOLCEL.2022.10.009 | 2022-10-26 | |
| 7RMG | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 3.0 | Active | 10.1038/S41589-021-00890-8 | 2021-11-03 | |
| 8JD5 | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JNJ-40411813
pubchem
gtoplig
chembl_ligand
drugbank
L-glutamic acid pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem ADX88178 pubchem gtoplig chembl_ligand |
PAMAgonistAgonist | 3.6 | Active | 10.1038/S41422-023-00830-2 | 2023-06-21 | |
| 9AUC | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcitonin gene-rela...
pubchem
|
Agonist | 2.4 | Active | 10.1021/ACS.BIOCHEM.4C00114 | 2024-04-24 | |
| 8JIM | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3354065
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.MOLCEL.2023.07.030 | 2023-09-06 | |
| 8IY6 | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ENDOTHELIN
chembl_ligand
pubchem
|
Agonist | 3.1 | Active | 10.7554/ELIFE.85821 | 2023-08-16 | |
| 9IZG | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lysophosphatidic aci...
pubchem
|
Agonist | 3.0 | Active | 2025-01-01 | ||
| 7MBY | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL216166
chembl_ligand
pubchem
|
Agonist | 2.4 | Active | 10.1371/JOURNAL.PBIO.3001295 | 2021-05-26 | |
| 7JJO | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LEVISOPRENALINE
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 2.6 | Active | 10.1016/J.MOLCEL.2020.08.001 | 2020-09-02 | |
| 7XZ6 | GP119 | GPR119 | GPR18, GPR55 and GPR119 | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
APD668
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.8 | Active | 10.1038/S41594-022-00816-5 | 2022-08-24 | |
| 6LMK | GLR | glucagon | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
glucagon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
pubchem
pubchem
pubchem
pubchem
|
Agonist | 3.7 | Active | 10.1126/SCIENCE.AAZ5346 | 2020-04-01 | |
| 5V57 | SMO | SMO | Frizzled | F (Frizzled) | Human | Transient_transfection | HEK293F | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
N-methyl-N-[1-[4-(2-...
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/NCOMMS15383 | 2017-05-24 | |
| 7D68 | GLP2R | GLP-2 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
glucagon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
pubchem
pubchem
pubchem
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41422-020-00442-0 | 2020-12-16 | |
| 8GG6 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 6H7N | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(S)-Xamoterol
pubchem
|
Agonist | 2.5 | Active | 10.1101/436212 | 2018-10-17 | |
| 8T1W | GPR6 | GPR6 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CVN424
pubchem
gtoplig
chembl_ligand
chembl_ligand
drugbank
pubchem
|
Inverse agonist | 3.5 | Inactive | 10.1126/SCISIGNAL.ADO8741 | 2024-12-04 | |
| 7TYL | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Amylin rat
pubchem
|
Agonist | 3.3 | Active | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | |
| 9IQT | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
nicotinic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 2.9 | Active | 10.1016/J.JMB.2024.168795 | 2024-10-02 | |
| 6G79 | 5HT1B | 5-HT1B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | Cryo-EM | Volta phase plate, Falcon III detector (FEI Titan Krios, 300kV) | 5 chems | 7.5-7.5 | 4°C |
donitriptan
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.8 | Active | 10.1038/S41586-018-0241-9 | 2018-06-20 | ||
| 9CBL | ADA2A | α2A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(-)-adrenaline
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
|
Agonist | 2.8 | Active | 10.1038/S12276-024-01296-X | 2024-09-11 | |
| 9BJK | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
naloxone
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
(2S)-3-(3-methoxy-4-... pubchem |
AntagonistNAM | 3.3 | Inactive | 2024-07-17 | ||
| 8K2X | CXCR3 | CXCR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
C-X-C motif chemokin...
|
Agonist | 3.2 | Active | 10.1038/S41421-023-00617-0 | 2023-11-29 | |
| 8UGW | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CGS 21680
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 3.9 | Active | 2024-12-18 | ||
| 6LI1 | GPR52 | GPR52 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Inactive | 10.1038/S41586-020-2019-0 | 2020-02-26 | |
| 6LPL | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.0 | Inactive | 10.1038/S41598-020-76277-X | 2020-11-25 | |
| 7VDM | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 3.0 | Active | 10.1038/S41586-021-04077-Y | 2021-12-01 | |
| 8WWH | MCHR1 | MCH1 | Melanin-concentrating hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 2024-11-13 | ||
| 8ZJD | KISSR | kisspeptin | Kisspeptin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Kisspeptin-10
pubchem
|
Agonist | 3.1 | Active | 2024-07-03 | ||
| 6ZIN | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
meclinertant
pubchem
gtoplig
chembl_ligand
drugbank
|
Inverse agonist | 2.6 | Inactive | 10.1126/sciadv.abe5504 | 2021-02-10 | |
| 8XOH | GPER1 | GPER | Estrogen (G protein-coupled) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PGE2
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41422-024-00963-Y | 2024-04-10 | |
| 7PIU | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
setmelanotide
pubchem
gtoplig
drug_central
chembl_ligand
drugbank
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41422-021-00569-8 | 2021-11-17 | |
| 9JKQ | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
METHAMPHETAMINE
chembl_ligand
pubchem
|
Agonist | 2.7 | Active | 10.1021/ACS.JMEDCHEM.4C01961 | 2024-10-16 | |
| 8HCX | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ENDOTHELIN
chembl_ligand
pubchem
|
Agonist | 3.5 | Active | 2023-03-22 | ||
| 8Y69 | LGR4 | LGR4 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
R-spondin-2
|
Agonist | 3.4 | Inactive | 2024-12-04 | ||
| 8XOF | GPER1 | GPER | Estrogen (G protein-coupled) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N1-(7-Chloroquinolin...
pubchem
|
Agonist | 2.6 | Active | 2024-04-10 | ||
| 8IHH | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-butyl-1H-pyrazole-...
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.1 | Active | 10.1038/S41467-023-41650-7 | 2023-08-30 | |
| 7WUJ | AGRG4 | ADGRG4 | ADGRG | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.3 | Active | 10.1038/S41586-022-04590-8 | 2022-04-27 | |
| 8TRC | GRM3 | mGlu3 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 3.3 | Inactive | 10.1101/2023.08.13.552748 | 2024-07-31 | |
| 6H7L | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Dobutamine
pubchem
|
Agonist | 2.7 | Active | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | |
| 8ZSS | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
RO5256390
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.1 | Active | 2024-07-24 | ||
| 7JHJ | Q3KSP2 | BILF1 | Unclassified | A (Rhodopsin) | strain GD1 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 10.1016/J.IMMUNI.2021.06.001 | 2021-07-07 | |
| 8XYD | PTAFR | PAF | Platelet-activating factor | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PAF
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
|
Agonist | 2.9 | Active | 10.1016/J.CELREP.2024.114422 | 2024-11-13 | |
| 7XK8 | NMUR2 | NMU2 | Neuromedin U | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Neuromedin U-25 (hum...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41467-022-34814-4 | 2023-02-22 | |
| 7CX3 | PE2R2 | EP2 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
taprenepag
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.8 | Active | 10.1126/SCIADV.ABF1268 | 2021-05-05 | |
| 8KH4 | GP161 | GPR161 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 10.1038/S41467-023-41654-3 | 2023-10-11 | |
| 6WI9 | SCTR | secretin | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SECRETIN
chembl_ligand
pubchem
drugbank
pubchem
|
Agonist | 4.3 | Active | 10.1038/S41467-020-17791-4 | 2020-08-12 | |
| 6D35 | Q98SW5 | SMO | Frizzled | F (Frizzled) | African clawed frog | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.5 | 20°C |
Cholesterol
pubchem
|
Agonist | 3.9 | Active | 10.1016/J.CELL.2018.04.029 | 2018-05-23 | |
| 5XRA | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | Transient_transfection | HEK293T | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.4-6.4 | 20°C |
AM11542
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.8 | Active | 2017-07-12 | ||
| 8TR2 | GRM3 | mGlu3 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(1S,4R,5R,6S)-4-amin...
pubchem
|
Agonist | 3.5 | Active | 10.1101/2023.08.13.552748 | 2024-07-31 | |
| 8W8R | GP101 | GPR101 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
1-(4-Methylpyridin-2...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41589-023-01456-6 | 2024-01-03 | |
| 8HSC | GPR20 | GPR20 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 10.1038/S41421-023-00520-8 | 2023-03-08 | |
| 6IQL | DRD4 | D4 | Dopamine | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L745870
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.5 | Inactive | 10.7554/ELIFE.48822 | 2019-12-04 | |
| 8YUT | HRH2 | H2 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
amthamine
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.7 | Active | 2024-06-05 | ||
| 8Y45 | OPRD | δ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ADL5859
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.5 | Active | 2024-11-27 | ||
| 6TPN | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
HTL6641
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.6 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
| 9IJA | T2R14 | TAS2R14 | Taste 2 | T2 (Taste 2) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 28.1 [PMID:...
pubchem
gtoplig
chembl_ligand
Cholesterol pubchem |
Allosteric agonistAgonist | 3.1 | Inactive | 2024-07-24 | ||
| 4RWD | OPRD | δ | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
DIPP-NH2
|
Antagonist | 2.7 | Inactive | 10.1038/NSMB.2965 | 2015-01-14 | |
| 9GYO | GPBAR | GPBA | Bile acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL2331646
chembl_ligand
pubchem
|
Agonist | 2.5 | Active | 2024-10-09 | ||
| 8HJ2 | GPR21 | GPR21 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.8 | Active | 10.1038/S41467-023-35882-W | 2023-03-15 | |
| 8IHJ | HCAR3 | HCA3 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5S)-5-methyl-4-oxo-...
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41467-023-41650-7 | 2023-08-30 | |
| 8JD6 | GRM4 | mGlu4 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
VU0364770
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.4 | Active | 10.1038/S41422-023-00830-2 | 2023-06-21 | |
| 6IGL | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
sovateltide
pubchem
gtoplig
chembl_ligand
gtoplig
pubchem
pubchem
pubchem
drugbank
|
Agonist (partial) | 2.7 | Inactive | 10.1038/S41467-018-07094-0 | 2018-11-21 | |
| 8JT6 | 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
1-(4-fluorophenyl)-4...
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.CELL.2024.02.034 | 2024-02-28 | |
| 6RZ9 | CLTR2 | CysLT2 | Leukotriene | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ONO-2770372
pubchem
|
Antagonist | 2.7 | Active | 10.1038/S41467-019-13348-2 | 2019-12-11 | |
| 9IYA | GPR55 | GPR55 | GPR18, GPR55 and GPR119 | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
4-(3-Bromo-5-ethoxy-...
pubchem
|
Antagonist | 3.0 | Active | 2025-01-01 | ||
| 4GRV | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C |
JMV431
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1038/NATURE11558 | 2012-10-17 | |
| 7K15 | LT4R1 | BLT1 | Leukotriene | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-(tert-butylsulfony...
pubchem
|
Antagonist | 2.9 | Inactive | 10.1038/S41467-021-23149-1 | 2021-02-17 | |
| 7Y35 | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
abaloparatide
pubchem
|
Agonist | 2.9 | Active | 2023-07-05 | ||
| 6FKD | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
5-chloro-2-(2-oxo-2-...
pubchem
|
Agonist | 2.5 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
| 8ZFJ | E7FEL0 | GPR4 | A orphans | A (Rhodopsin) | Zebrafish | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 2024-08-07 | ||
| 5JTB | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.8 | Inactive | 10.1126/SCIADV.1602952 | 2017-05-31 | |
| 8XVJ | EDNRA | ETA | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
macitentan
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 3.3 | Inactive | 2024-08-28 | ||
| 6BD4 | FZD4 | FZD4 | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.4 | Inactive | 10.1038/S41586-018-0447-X | 2018-08-22 | |
| 6PT0 | CNR2 | CB2 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
WIN55212-2
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2020.01.007 | 2020-02-12 | |
| 8KGG | P2Y10 | P2RY10 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2~{S})-2-$l^{4}-aza...
|
Agonist | 3.1 | Active | 10.1016/J.CHEMBIOL.2024.08.005 | 2024-07-31 | |
| 7TD4 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
siponimod
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41467-022-28417-2 | 2022-02-09 | |
| 6C1R | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.5-6.5 | 10°C |
avacopan
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
PMX53 pubchem gtoplig chembl_ligand |
NAMAntagonist | 2.2 | Inactive | 10.1038/S41594-018-0067-Z | 2018-05-30 | |
| 9IJE | ADRB3 | β3 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(-)-adrenaline
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
|
Agonist | 2.3 | Active | 10.1002/CPLU.202400288 | 2024-08-21 | |
| 8ITL | GIPR | GIP | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 10.1073/PNAS.2306145120 | 2023-10-18 | |
| 9AXF | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cyclomethyltryptopha...
pubchem
tecalcet pubchem gtoplig chembl_ligand |
AgonistPAM | 3.5 | Active | 10.1038/S41586-024-07331-1 | 2024-04-17 | |
| 8GNE | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Sipagladenant
pubchem
|
Inverse agonist | 2.3 | Inactive | 10.1124/MOLPHARM.122.000633 | 2023-03-22 | |
| 6VJM | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 4.0 | Inactive | 10.1038/S41586-020-2408-4 | 2020-06-10 | |
| 5XF1 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C |
NNC0640
pubchem
gtoplig
|
NAM | 3.2 | Inactive | 2017-05-24 | ||
| 2Z73 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Japanese flying squid | NA | Native | Squid | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 5 chems | 6.4-6.4 | 4°C |
Retinal (11-cis)
pubchem
|
Inverse agonist | 2.5 | Inactive | 10.1038/NATURE06925 | 2008-05-13 | ||
| 7EPF | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(8~{R})-4-[2,4-Bis(f...
pubchem
|
NAM | 2.7 | Inactive | 10.1038/S41586-021-03641-W | 2021-06-23 | |
| 7EVZ | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
cenerimod
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41422-021-00566-X | 2021-09-29 | |
| 6GT3 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
imaradenant
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.0 | Inactive | 2019-06-26 | ||
| 7EZC | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
UK-432,097
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.8 | Active | 10.1107/S2052252522001907 | 2022-04-13 | |
| 5TGZ | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | Transient_transfection | HEK293F | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.4 | 20°C |
AM6538
pubchem
gtoplig
|
Antagonist | 2.8 | Inactive | 10.1016/J.CELL.2016.10.004 | 2016-11-02 | |
| 7TRQ | ACM4 | M4 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
VU0467154
pubchem
gtoplig
chembl_ligand
iperoxo pubchem gtoplig chembl_ligand |
PAMAgonist | 2.5 | Active | 2023-05-17 | ||
| 7XMR | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SOMATOSTATIN
chembl_ligand
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41422-022-00679-X | 2022-08-03 | |
| 4YAY | AGTR1 | AT1 | Angiotensin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 6 chems | 5.0-6.0 | 20°C |
ZD-7155
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.9 | Inactive | 10.1016/J.CELL.2015.04.011 | 2015-04-22 | |
| 2YCW | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | NA | 3 chems | 8.1-8.1 | NA |
Carazolol
pubchem
|
Antagonist | 3.0 | Inactive | 10.1073/PNAS.1100185108 | 2011-06-01 | ||
| 6OY9 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (all-trans)
pubchem
|
Agonist | 3.9 | Active | 10.1016/J.MOLCEL.2019.06.007 | 2019-07-24 | |
| 5DHH | OPRX | NOP | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.4-6.4 | 20°C |
SB 612111
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.0 | Inactive | 10.1016/J.STR.2015.07.024 | 2015-10-21 | |
| 6IBB | SUCR1 | succinate | Succinate | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.1 | Active | 10.1038/S41586-019-1663-8 | 2019-08-14 | |
| 8JIR | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SAR425899
|
Agonist | 2.6 | Active | 10.1073/PNAS.2303696120 | 2023-09-06 | |
| 6TQ6 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4592653
chembl_ligand
pubchem
|
Antagonist | 2.6 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
| 8GUQ | CNR2 | CB2 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
olorinab
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.1 | Active | 10.1038/S41467-023-37112-9 | 2023-05-10 | |
| 8GAG | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
methyl (2R)-2-({(1M)...
pubchem
|
Agonist | 3.3 | Active | 2024-02-28 | ||
| 8DCS | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cyanopindolol
pubchem
|
Antagonist | 2.5 | Active | 10.1038/S41467-022-31823-1 | 2022-07-27 | |
| 8W8S | GP101 | GPR101 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
1-(4-Methylpyridin-2...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41589-023-01456-6 | 2024-01-03 | |
| 6CMO | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | Cryo-EM | FEI TITAN Krios microscope,Gatan K2 Summit direct electron camera,GIF-quantum energy filter (Gatan) | 4 chems | 7.2-7.2 | 4°C |
Apo (no ligand)
|
Apo (no ligand) | 4.5 | Active | 10.1038/S41586-018-0215-Y | 2018-06-20 | ||
| 6Z4V | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JMV431
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.6 | Intermediate | 10.1126/sciadv.abe5504 | 2021-02-10 | |
| 7W0M | APJ | apelin | Apelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(1R,2S)-N-[4-(2,6-di...
pubchem
|
Agonist | 3.7 | Active | 10.1038/S41594-022-00797-5 | 2022-07-27 | |
| 5NJ6 | PAR2 | PAR2 | Proteinase-activated | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 5.5-6.2 | 20°C |
Apo (no ligand)
|
Apo (no ligand) | 4.0 | Active | 10.1038/NATURE22309 | 2017-05-03 | |
| 7AD3 | STE2 | STE2 | STE2 | D1 (Ste2-like fungal pheromone) | strain ATCC 204508 / S288c | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Alpha-factor mating ...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-020-2994-1 | 2020-12-09 | |
| 7F83 | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PF-05190457
pubchem
gtoplig
chembl_ligand
drugbank
|
Inverse agonist | 2.9 | Inactive | 10.1038/S41467-022-27975-9 | 2022-01-19 | |
| 7WXW | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 10.1038/S41467-022-33173-4 | 2022-09-28 | |
| 7XJJ | GALR1 | GAL1 | Galanin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
galanin
pubchem
gtoplig
chembl_ligand
gtoplig
pubchem
pubchem
pubchem
pubchem
|
Agonist | 3.3 | Active | 2023-05-03 | ||
| 9AVL | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cyclomethyltryptopha...
pubchem
tecalcet pubchem gtoplig chembl_ligand |
AgonistPAM | 3.8 | Active | 2024-04-17 | ||
| 7YKD | CML1 | chemerin | Chemerin receptor | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
chemerin C-terminal ...
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1073/PNAS.2214324120 | 2023-04-19 | |
| 8XWQ | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ENDOTHELIN
chembl_ligand
pubchem
|
Agonist | 4.6 | Active | 10.1038/S42003-024-06905-Z | 2024-10-02 | |
| 7JNI | AGTR2 | AT2 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
olodanrigan
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 3.0 | Active | 10.1073/PNAS.2116289119 | 2022-02-09 | |
| 7VV0 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PAMP-12
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-021-04077-Y | 2021-12-01 | |
| 7EW1 | S1PR5 | S1P5 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
siponimod
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41422-021-00566-X | 2021-09-29 | |
| 8C9W | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AB928
pubchem
gtoplig
chembl_ligand
pubchem
|
Antagonist | 2.1 | Inactive | 10.1038/S42004-023-00894-6 | 2023-07-12 | |
| 7VUY | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PAMP-12
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41586-021-04077-Y | 2021-12-01 | |
| 8GG7 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8GEB | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.6 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7CMV | DRD3 | D3 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL70565
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 2.7 | Active | 10.1016/J.MOLCEL.2021.01.003 | 2021-03-10 | |
| 7XW6 | TSHR | TSH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
M22 antibody heavy c...
M22 antibody light c... N-[4-[[5-[(2S)-3-ben... pubchem |
AgonistAgonistPAM | 2.8 | Active | 10.1038/S41586-022-05173-3 | 2022-08-17 | |
| 7F1Q | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCL3
gtoplig
|
Agonist | 2.9 | Active | 2021-07-14 | ||
| 4PXF | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 3 chems | 6.0-6.0 | 4°C |
B-Octylglucoside
pubchem
|
unknown | 2.8 | Active | 10.1038/NCOMMS5801 | 2014-09-17 | ||
| 8T8M | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
quisqualate
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
pubchem
|
Agonist | 3.0 | Intermediate | 10.1101/2023.08.29.555158 | 2023-10-11 | |
| 6LML | GLR | glucagon | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
glucagon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
pubchem
pubchem
pubchem
pubchem
|
Agonist | 3.9 | Active | 10.1126/SCIENCE.AAZ5346 | 2020-04-01 | |
| 7WUQ | AGRG2 | ADGRG2 | ADGRG | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1038/S41586-022-04590-8 | 2022-04-27 | |
| 8WGB | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
VU0155041
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.7 | Active | 10.1038/S41467-024-54744-7 | 2024-10-30 | |
| 9K1D | FFAR2 | FFA2 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
butyric acid
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.3 | Active | 10.1016/J.CELREP.2024.115024 | 2024-12-11 | |
| 8HPT | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
C5a
|
Agonist | 3.4 | Active | HTTPS://DOI.ORG/10.1016/J.CELL.2023.09.020 | 2023-10-18 | |
| 6C1Q | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.5-6.5 | 10°C |
NDT9513727
pubchem
gtoplig
chembl_ligand
PMX53 pubchem gtoplig chembl_ligand |
NAMAntagonist | 2.9 | Inactive | 10.1038/S41594-018-0067-Z | 2018-05-30 | |
| 7YP7 | AGRG2 | ADGRG2 | ADGRG | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 2022-08-24 | ||
| 5KW2 | FFAR1 | FFA1 | Free fatty acid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 8.5-8.5 | 20°C |
(3~{S})-3-cyclopropy...
pubchem
|
Allosteric agonist | 2.8 | Active | 10.1038/S41467-017-01240-W | 2018-05-02 | |
| 8KFY | CCR8 | CCR8 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZK 756326
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.1 | Active | 10.1126/SCIADV.ADJ7500 | 2024-02-07 | |
| 7EZH | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCK-8
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 3.2 | Active | 10.1038/S41589-021-00841-3 | 2021-08-25 | |
| 4BUO | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | NA | E. coli BL21(DE3) | Bacteria | 6 chemicals | 6 steps | vapour diffusion | Sitting drop | 5 chems | 9.4-9.4 | 4°C |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 2.8 | Inactive | 10.1073/PNAS.1317903111 | 2014-01-29 | ||
| 6KK1 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PF-06372222
pubchem
|
NAM | 2.8 | Inactive | 2019-11-13 | ||
| 8TYW | GPR6 | GPR6 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.4 | Active | 10.1126/SCISIGNAL.ADO8741 | 2024-12-04 | |
| 6PS8 | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL15060
chembl_ligand
pubchem
|
Agonist | 3.3 | Inactive | 10.1107/S2052252519013137 | 2019-11-13 | |
| 7WC6 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Lysergide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.6 | Inactive | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | |
| 4L6R | GLR | glucagon | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C |
Glucagon model
|
Agonist | 3.3 | Inactive | 10.1038/nature12393 | 2013-07-24 | |
| 7L0S | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 4.5 | Active | 10.1038/S41594-020-00554-6 | 2021-01-06 | |
| 6TOT | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lemborexant
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Antagonist | 2.2 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-15 | |
| 4PXZ | P2Y12 | P2Y12 | P2Y | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-6.0 | 20°C |
2MeSADP
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 2.5 | Active | 10.1038/NATURE13288 | 2014-04-30 | |
| 8EF5 | OPRM | μ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
fentanyl
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.3 | Active | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | |
| 8THK | ADA1A | α1A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL133451
chembl_ligand
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41467-023-40524-2 | 2023-08-16 | |
| 8GG3 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7VV5 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 48/80
pubchem
gtoplig
|
Agonist | 2.8 | Active | 10.1038/S41586-021-04077-Y | 2021-12-01 | |
| 8XJL | PF2R | FP | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PGF<sub>2α</su...
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 2.8 | Active | 10.1016/J.CELREP.2024.113893 | 2024-02-28 | |
| 6PB1 | CRFR2 | CRF2 | Corticotropin-releasing factor | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Urocortin
pubchem
|
Agonist | 2.8 | Active | 10.1016/J.MOLCEL.2020.01.013 | 2020-02-12 | |
| 6A93 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
risperidone
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/S41594-018-0180-Z | 2019-02-13 | |
| 7SK8 | ACKR3 | ACKR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Stromal cell-derived...
(1R)-4-[7-(3-carboxy... pubchem |
AgonistAgonist (partial) | 3.3 | Active | 10.1126/SCIADV.ABN8063 | 2022-07-27 | |
| 8FYT | 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Lysergide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.6 | Active | 10.1038/S41586-024-07403-2 | 2024-05-15 | |
| 8E3X | PACR | PAC1 | VIP and PACAP | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[Ac-His<sup>1</sup>]...
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.3 | Active | 10.1038/S41467-022-34629-3 | 2022-11-23 | |
| 7WXU | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1038/S41467-022-33173-4 | 2022-09-28 | |
| 7VDH | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 48/80
pubchem
gtoplig
|
Agonist | 2.9 | Active | 10.1038/S41586-021-04077-Y | 2021-12-01 | |
| 3QAK | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.5 | 20°C |
UK-432,097
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.7 | Active | 10.1126/SCIENCE.1202793 | 2011-03-09 | |
| 3PBL | DRD3 | D3 | Dopamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.5-7.5 | 20°C |
eticlopride
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.9 | Inactive | 10.1126/SCIENCE.1197410 | 2010-11-03 | |
| 8A2P | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1671936
chembl_ligand
pubchem
|
Antagonist | 3.5 | Inactive | 10.1107/S1600576723006428 | 2023-08-30 | |
| 6AK3 | PE2R3 | EP3 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PGE2
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41589-018-0171-8 | 2018-12-05 | |
| 7WU5 | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.0 | Active | 10.1038/S41586-022-04580-W | 2022-04-27 | |
| 6ZG9 | ACM1 | M1 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
7-fluoro-5-methyl-3-...
pubchem
|
Agonist | 2.5 | Inactive | 10.1016/J.CELL.2021.11.001 | 2021-10-06 | |
| 8GED | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7CZ5 | GHRHR | GHRH | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Somatoliberin
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41467-020-18945-0 | 2020-11-18 | |
| 6OT0 | SMO | SMO | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
24,25-Epoxy-choleste...
pubchem
|
Agonist | 3.9 | Active | 10.1038/S41586-019-1286-0 | 2019-06-12 | |
| 8I7W | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
GSK256073
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.4 | Active | 10.1038/S41467-023-42764-8 | 2024-02-07 | |
| 8F0J | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Pramlintide analogue...
|
Agonist | 2.0 | Active | 10.1038/S41589-023-01393-4 | 2023-08-02 | |
| 6W2X | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CGP55845
pubchem
1-Stearoyl-2-oleoyl-... pubchem |
Inverse agonistNAM | 3.6 | Inactive | 2020-07-01 | ||
| 8J6L | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
nicotinic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 3.1 | Active | 10.1016/J.CELREP.2023.113406 | 2024-04-03 | |
| 7ZBE | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (11-cis)
pubchem
|
Inverse agonist | 1.8 | Inactive | 10.1038/S41586-023-05863-6 | 2023-03-29 | |
| 6XBJ | SMO | SMO | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cholesterol
pubchem
|
Agonist | 3.9 | Active | 2020-09-30 | ||
| 8JEI | HCAR3 | HCA3 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
4-(<i>n</i>-propyl)a...
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.7 | Active | 10.1016/J.CELREP.2024.114895 | 2024-11-20 | |
| 7P02 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 2.9 | Active | 10.1126/SCIADV.ABK2872 | 2021-12-15 | |
| 6TQ4 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4590386
chembl_ligand
pubchem
|
Antagonist | 2.3 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
| 8TF5 | GPR6 | GPR6 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
oleic acid
pubchem
gtoplig
chembl_ligand
drug_central
|
Inverse agonist | 2.1 | Active | 10.1126/SCISIGNAL.ADO8741 | 2024-12-04 | |
| 7WJ5 | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SOMATOSTATIN
chembl_ligand
pubchem
|
Agonist | 3.7 | Active | 10.7554/ELIFE.76823 | 2022-07-13 | |
| 7XNA | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CYN 154806
pubchem
|
Antagonist | 2.7 | Inactive | 10.1038/S41422-022-00679-X | 2022-08-03 | |
| 8WPG | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
cinacalcet
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
Calcium pubchem |
AgonistAgonist | 2.7 | Inactive | 10.1038/S41422-023-00892-2 | 2023-11-22 | |
| 8JT8 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
1-(4-fluorophenyl)-4...
pubchem
|
Agonist | 2.7 | Inactive | 10.1016/J.CELL.2024.02.034 | 2024-02-28 | |
| 8ZPS | PRLHR | PrRP | Prolactin-releasing peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Prolactin-releasing ...
|
Agonist | 3.0 | Active | 10.1038/S41421-024-00724-6 | 2024-09-25 | |
| 7V68 | ACM4 | M4 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
iperoxo
pubchem
gtoplig
chembl_ligand
LY2119620 pubchem gtoplig chembl_ligand |
AgonistPAM | 3.4 | Active | 10.1038/S41467-022-30595-Y | 2022-05-11 | |
| 3DQB | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | hanging drops | 5 chems | 5.9-6.1 | 10°C |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 10.1038/NATURE07330 | 2008-09-23 | ||
| 8XIQ | SSR3 | SST3 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
NIT-FC0-NLE-A1D5B
|
Agonist | 2.7 | Active | 2024-07-03 | ||
| 8GGA | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 6LW5 | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL552527
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-020-15009-1 | 2020-03-25 | |
| 2J4Y | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Transient_transfection | COS1 | Mammalian | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 3 chems | 7.5-7.5 | 4°C |
Retinal (11-cis)
pubchem
|
Inverse agonist | 3.4 | Inactive | 10.1016/J.JMB.2007.03.007 | 2007-09-25 | ||
| 8JXX | HRH4 | H4 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
clobenpropit
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.1 | Active | 10.1038/S41467-024-46840-5 | 2024-03-20 | |
| 8A2O | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
theophylline
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 3.5 | Inactive | 10.1107/S1600576723006428 | 2023-08-30 | |
| 8WKZ | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[N-(3-{bis[2-(pyridi...
|
Antagonist | 3.3 | Intermediate | 10.1021/ACS.JMEDCHEM.3C01822 | 2024-08-07 | |
| 5CGD | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-6.8 | 20°C |
CHEMBL3603923
chembl_ligand
pubchem
|
NAM | 2.6 | Inactive | 10.1021/acs.jmedchem.5b00892 | 2015-08-12 | |
| 7SK6 | ACKR3 | ACKR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Stromal cell-derived...
|
Agonist | 4.0 | Active | 10.1126/SCIADV.ABN8063 | 2022-07-27 | |
| 4MQT | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.2-7.9 | 20°C |
iperoxo
pubchem
gtoplig
chembl_ligand
LY2119620 pubchem gtoplig chembl_ligand |
AgonistPAM | 3.7 | Active | 2013-11-27 | ||
| 7VV6 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 48/80
pubchem
gtoplig
|
Agonist | 3.3 | Active | 10.1038/S41586-021-04077-Y | 2021-12-01 | |
| 7X8S | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
WB4-24
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.1 | Active | 10.1073/PNAS.2200155119 | 2022-06-29 | |
| 3NY9 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.5-8.0 | 20°C |
CHEMBL1233771
chembl_ligand
pubchem
|
Inverse agonist | 2.8 | Inactive | 2010-08-11 | ||
| 6P9X | CRFR1 | CRF1 | Corticotropin-releasing factor | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Corticoliberin
pubchem
|
Agonist | 2.9 | Active | 10.1016/J.MOLCEL.2020.01.012 | 2020-02-05 | |
| 4UG2 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 3 chems | 7.0-7.0 | 22°C |
CGS 21680
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 2.6 | Active | 10.1124/mol.114.097360 | 2015-04-08 | |
| 8I7V | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-Methyl-4-oxidanyl-...
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-023-42764-8 | 2024-02-07 | |
| 7LCK | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
danuglipron
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.STR.2021.04.008 | 2021-01-20 | |
| 6FFH | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-6.8 | 20°C |
fenobam
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
pubchem
pubchem
pubchem
|
NAM | 2.7 | Inactive | 10.1021/ACS.JMEDCHEM.7B01722 | 2018-03-07 | |
| 8WWN | MCHR1 | MCH1 | Melanin-concentrating hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Melanin-concentratin...
|
Agonist | 2.7 | Active | 10.1038/S41421-024-00754-0 | 2024-11-13 | |
| 4EJ4 | OPRD | δ | Opioid | A (Rhodopsin) | Mouse | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.5-7.5 | 20°C |
naltrindole
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 3.4 | Inactive | 10.1038/NATURE11111 | 2012-05-16 | |
| 5ZKB | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AF-DX 384
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/S41589-018-0152-Y | 2018-11-21 | |
| 8J24 | FFAR2 | FFA2 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Acetic acid
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41422-023-00914-Z | 2024-01-24 | |
| 6DDF | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | Cryo-EM | Gatan K2 Summit direct electron camera , 300kV | 5 chems | 7.5-7.5 | 4°C |
DAMGO
pubchem
gtoplig
chembl_ligand
chembl_ligand
|
Agonist | 3.5 | Active | 10.1038/S41586-018-0219-7 | 2018-06-13 | ||
| 3ODU | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20°C |
isothiourea-1t
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.5 | Inactive | 2010-10-27 | ||
| 7V9L | GHRHR | GHRH | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.6 | Active | 10.1073/PNAS.2106606118 | 2022-04-06 | |
| 6IGK | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
endothelin-3
pubchem
gtoplig
|
Agonist | 2.0 | Inactive | 10.1038/S41467-018-07094-0 | 2018-11-21 | |
| 5TUD | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monopalmitolein (9.7 MAG) | 6 chems | 7.7-7.7 | 20°C |
ergotamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.0 | Active | 10.1073/PNAS.1700891114 | 2017-07-26 | |
| 8F0K | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
San385
|
Agonist | 1.9 | Active | 10.1038/S41589-023-01393-4 | 2023-08-02 | |
| 4BEY | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Stable_cells | HEK293S(TetR)GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 4 chems | 4.5-4.5 | 20°C |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1038/EMBOR.2013.44 | 2013-05-08 | ||
| 8YN7 | HRH3 | H3 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2R)-3-[(E)-hexadec...
pubchem
|
Agonist | 2.8 | Active | 2024-10-16 | ||
| 7EZM | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCK-8
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 2.9 | Active | 10.1038/S41589-021-00841-3 | 2021-08-25 | |
| 8A6D | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (11-cis)
pubchem
|
Agonist | 1.8 | Inactive | 10.1038/S41586-023-05863-6 | 2023-03-29 | |
| 6AQF | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Pichia Pastoris | P. pastoris SMD1163 | Yeast | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.5 | Inactive | 10.1016/J.CELL.2017.12.004 | 2018-01-10 | |
| 7EJK | ADA2A | α2A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
oxymetazoline
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.4 | Active | 10.1126/SCIADV.ABJ5347 | 2022-04-13 | |
| 3ZPR | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 3 chems | 9.0-9.0 | 4°C |
CHEMBL1559535
chembl_ligand
pubchem
|
Antagonist | 2.7 | Inactive | 10.1021/jm400140q | 2013-04-03 | ||
| 6PS3 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3799125
chembl_ligand
pubchem
|
Antagonist | 2.5 | Inactive | 10.1107/S2052252519013137 | 2019-11-13 | |
| 7DTV | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-tryptophan
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
Calcium pubchem |
PAMAgonist | 3.5 | Active | 10.1038/S41422-021-00474-0 | 2021-03-10 | |
| 8YN4 | HRH2 | H2 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
histamine
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
gtoplig
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41467-024-52585-Y | 2024-10-09 | |
| 6D26 | PD2R2 | DP2 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
fevipiprant
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.8 | Inactive | 10.1016/J.MOLCEL.2018.08.009 | 2018-10-03 | |
| 7YMH | ADA1A | α1A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Noradrenaline
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41467-023-39310-X | 2023-07-05 | |
| 7S0G | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LEVISOPRENALINE
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 3.9 | Active | 10.1038/S41594-021-00679-2 | 2021-11-17 | |
| 8P15 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 5.9 | Active | 2024-11-20 | ||
| 7NA8 | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ibutamoren
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.7 | Active | 10.1038/S41467-021-26735-5 | 2021-12-15 | |
| 8IRR | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
rotigotine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41422-023-00808-0 | 2023-06-21 | |
| 7T6T | FPR1 | FPR1 | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
synthetic peptide
|
Agonist | 3.2 | Active | 10.1038/S41467-022-28586-0 | 2022-03-30 | |
| 7F9Y | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ghrelin
gtoplig
|
Agonist | 2.9 | Active | 10.1038/S41467-021-25364-2 | 2021-08-18 | |
| 3PDS | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 3 chemicals | 3 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.7-6.7 | 20°C |
FAUC50
pubchem
|
Agonist | 3.5 | Inactive | 10.1038/NATURE09665 | 2011-01-12 | |
| 7YJ4 | RL3R2 | RXFP4 | Relaxin family peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Insulin-like peptide...
pubchem
Insulin-like peptide... pubchem |
AgonistAgonist | 3.2 | Active | 10.1038/S41467-023-36182-Z | 2023-03-01 | |
| 6IIU | TA2R | TP | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ramatroban
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
gtoplig
pubchem
|
Antagonist | 2.5 | Inactive | 10.1038/S41589-018-0170-9 | 2018-12-19 | |
| 7W41 | GRPR | BB2 | Bombesin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PD 176252
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.0 | Inactive | 10.1073/PNAS.2216230120 | 2023-02-22 | |
| 7CA3 | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
BHFF
pubchem
|
PAM | 4.5 | Active | 10.1016/J.JMB.2020.09.023 | 2020-11-11 | |
| 5DSG | ACM4 | M4 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.5-8.0 | 20°C |
tiotropium
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
chembl_ligand
chembl_ligand
pubchem
|
Antagonist | 2.6 | Inactive | 10.1038/NATURE17188 | 2016-03-16 | |
| 6KO5 | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1956994
chembl_ligand
pubchem
|
Antagonist | 3.3 | Inactive | 10.1038/S41467-020-17554-1 | 2020-08-12 | |
| 7YMJ | ADA1A | α1A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
tamsulosin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 3.4 | Inactive | 10.1038/S41467-023-39310-X | 2023-07-05 | |
| 6KPC | CNR2 | CB2 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AM12033
pubchem
|
Agonist | 3.2 | Inactive | 10.1016/J.CELL.2020.01.008 | 2020-02-12 | |
| 8RQL | T2R14 | TAS2R14 | Taste 2 | T2 (Taste 2) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
flufenamic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.0 | Active | 10.1038/S41467-024-54157-6 | 2024-11-27 | |
| 8GGW | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.6 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8JRV | GLR | glucagon | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
glucagon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
pubchem
pubchem
pubchem
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-023-06420-X | 2023-08-16 | |
| 7TYI | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Amylin rat
pubchem
|
Agonist | 3.3 | Active | 10.1126/SCIENCE.ABM9609 | 2022-03-30 | |
| 7XP5 | T2R46 | TAS2R46 | Taste 2 | T2 (Taste 2) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 10.1126/SCIENCE.ABO1633 | 2022-10-12 | |
| 6ME7 | MTR1B | MT2 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL15060
chembl_ligand
pubchem
|
Agonist | 3.2 | Inactive | 2019-04-24 | ||
| 4AMI | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | sitting drops | 3 chems | 9.0-9.0 | 4°C |
Bucindolol
pubchem
|
Agonist | 3.2 | Inactive | 2012-05-23 | |||
| 4U14 | ACM3 | M3 | Acetylcholine (muscarinic) | A (Rhodopsin) | Rat | Baculovirus | Sf9 | Insect | 9 chemicals | 9 steps | sponge mesophase | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 8.1-8.1 | 298 K |
tiotropium
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
chembl_ligand
chembl_ligand
pubchem
|
Antagonist | 3.6 | Inactive | 10.1016/J.STR.2014.08.022 | 2014-11-26 | |
| 6DDE | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | Cryo-EM | Gatan K2 Summit direct electron camera , 300kV | 5 chems | 7.5-7.5 | 4°C |
DAMGO
pubchem
gtoplig
chembl_ligand
chembl_ligand
|
Agonist | 3.5 | Active | 10.1038/S41586-018-0219-7 | 2018-06-13 | ||
| 5EE7 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | Transient_transfection | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-6.5 | 20°C |
Octaethylene glycol ...
pubchem
MK-0893 pubchem gtoplig chembl_ligand drugbank |
AntagonistNAM | 2.5 | Inactive | 10.1038/NATURE17414 | 2016-04-20 | |
| 8IZ4 | GPR34 | GPR34 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Lysergide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.9 | Active | 2024-04-10 | ||
| 6X1A | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
danuglipron
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.5 | Active | 10.1016/J.MOLCEL.2020.09.020 | 2020-09-09 | |
| 7XJH | ADRB3 | β3 | Adrenoceptors | A (Rhodopsin) | Dog | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LEVISOPRENALINE
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 3.3 | Active | 10.1016/J.MOLCEL.2021.06.024 | 2022-05-04 | |
| 7UL2 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
meclinertant
pubchem
gtoplig
chembl_ligand
drugbank
|
Inverse agonist | 2.4 | Inactive | 10.1038/S41594-022-00859-8 | 2022-06-29 | |
| 8JJL | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
olodaterol
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Agonist | 3.2 | Inactive | 10.1038/S41589-023-01389-0 | 2023-09-06 | |
| 1GZM | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 3 chems | 8.5-8.5 | 18°C |
Retinal (11-cis)
pubchem
|
Inverse agonist | 2.7 | Inactive | 10.1016/J.JMB.2004.08.090 | 2003-11-20 | ||
| 7VH0 | MTR1B | MT2 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ramelteon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41467-022-28111-3 | 2022-03-02 | |
| 8WMA | FZD4 | FZD4 | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.5 | Active | 10.1038/S41467-024-52174-Z | 2024-09-11 | |
| 8UO2 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.6 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 6Z10 | SUCR1 | succinate | Succinate | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4751488
chembl_ligand
pubchem
|
Antagonist | 2.3 | Active | 10.1021/acs.jmedchem.0c01020 | 2020-09-16 | |
| 8GDA | PE2R4 | EP4 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2S,5R)-5-[(1E,3S)-4...
pubchem
|
Agonist | 3.3 | Active | 10.1073/PNAS.2216329120 | 2024-01-10 | |
| 7YK7 | RL3R2 | RXFP4 | Relaxin family peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
DC591053
pubchem
gtoplig
|
Agonist | 2.8 | Active | 10.1038/S41467-023-36182-Z | 2023-03-01 | |
| 8UNT | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7YDM | AGRE5 | ADGRE5 | ADGRE | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1016/J.CHEMBIOL.2023.08.003 | 2023-07-12 | |
| 8HNL | CXCR3 | CXCR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(3S)-N-[(2S)-5-carba...
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41594-023-01175-5 | 2023-11-29 | |
| 7FEE | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CP55940
pubchem
gtoplig
chembl_ligand
gtoplig
6-methyl-3-[(1S)-2-n... pubchem |
AgonistPAM | 2.7 | Inactive | 10.1038/S41589-022-01038-Y | 2022-06-15 | |
| 7F9Z | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
GHRP-6
pubchem
gtoplig
|
Agonist | 3.2 | Active | 10.1038/S41467-021-25364-2 | 2021-08-18 | |
| 1L9H | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 6.0-6.0 | 4°C |
Retinal (11-cis)
pubchem
|
Inverse agonist | 2.6 | Inactive | 10.1073/PNAS.082666399 | 2002-05-15 | ||
| 7XAV | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lanreotide
pubchem
gtoplig
drugbank
|
Agonist | 2.9 | Active | 10.1038/S41421-022-00405-2 | 2022-08-31 | |
| 7DUQ | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-Tert-butyl-6,7-dic...
pubchem
CHEMBL410972 chembl_ligand pubchem pubchem |
Ago-PAMAgonist | 2.5 | Active | 10.1038/S41467-021-24058-Z | 2021-07-14 | |
| 8K6N | NPY2R | Y2 | Neuropeptide Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
neuropeptide Y
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
pubchem
pubchem
pubchem
|
Agonist | 3.2 | Active | 2024-07-31 | ||
| 7UM4 | 5HT5A | 5-HT5A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3654198
chembl_ligand
pubchem
|
Antagonist | 2.8 | Inactive | 10.1038/S41594-022-00796-6 | 2022-07-20 | |
| 5VEX | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.8 | 20°C |
NNC0640
pubchem
gtoplig
|
NAM | 3.0 | Inactive | 10.1038/NATURE22378 | 2017-05-17 | |
| 7W55 | NMUR2 | NMU2 | Neuromedin U | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Neuromedin U-25 (hum...
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-022-29683-W | 2022-04-20 | |
| 7W0L | APJ | apelin | Apelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(1R,2S)-N-[4-(2,6-di...
pubchem
|
Agonist | 3.6 | Active | 10.1038/S41594-022-00797-5 | 2022-07-27 | |
| 6FK7 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
(2~{S})-2-(4-chlorop...
pubchem
|
Agonist | 2.6 | Active | 2018-04-04 | |||
| 8JZZ | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
C5a des-Arg
gtoplig
|
Agonist | 3.3 | Active | 10.1016/J.CELL.2023.09.020 | 2023-10-18 | |
| 2I35 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 2 chemicals | 2 steps | vapour diffusion | sitting drops | 5 chems | 7.0-8.0 | 5°C |
Retinal (11-cis)
pubchem
|
Inverse agonist | 3.8 | Inactive | 2006-10-17 | |||
| 7F8U | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lintitript
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.8 | Inactive | 10.1038/S41589-021-00866-8 | 2021-10-13 | |
| 7XJL | GALR2 | GAL2 | Galanin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Spexin
pubchem
|
Agonist | 3.5 | Active | 10.1073/PNAS.2121465119 | 2022-06-29 | |
| 5V56 | SMO | SMO | Frizzled | F (Frizzled) | Human | Transient_transfection | HEK293F | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
N-methyl-N-[1-[4-(2-...
pubchem
|
Antagonist | 2.9 | Inactive | 10.1038/NCOMMS15383 | 2017-05-24 | |
| 8IKL | AGRE5 | ADGRE5 | ADGRE | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.3 | Active | 10.1016/J.MOLCEL.2023.12.020 | 2024-01-24 | |
| 8JD4 | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-glutamic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41422-023-00830-2 | 2023-06-21 | |
| 7W6P | ADA2A | α2A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-pyridin-4-ylisoqui...
pubchem
|
Agonist | 3.5 | Active | 10.1126/SCIENCE.ABN7065 | 2022-09-28 | |
| 8J46 | O52E4 | OR52E4 | Odorant family 52 | O1 (fish-like odorant) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.7 | Active | 10.1038/S41467-023-43983-9 | 2023-12-20 | |
| 7VVN | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
teriparatide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
pubchem
pubchem
pubchem
pubchem
pubchem
|
Agonist | 3.8 | Active | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | |
| 8UNM | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7UM5 | 5HT5A | 5-HT5A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-CT
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.7 | Active | 10.1038/S41594-022-00796-6 | 2022-07-20 | |
| 8HBD | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
sovateltide
pubchem
gtoplig
chembl_ligand
gtoplig
pubchem
pubchem
pubchem
drugbank
|
Agonist | 3.0 | Active | 2023-03-22 | ||
| 8IRS | DRD2 | D2 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
rotigotine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41422-023-00808-0 | 2023-06-07 | |
| 6NBH | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Long-acting parathyr...
|
Agonist | 3.5 | Active | 10.1126/SCIENCE.AAV7942 | 2019-04-17 | |
| 4QIN | SMO | SMO | Frizzled | F (Frizzled) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 6 chems | 7.2-7.2 | 20°C |
SAG1.5
pubchem
|
Agonist | 2.6 | Inactive | 10.1038/NCOMMS5355 | 2014-07-23 | |
| 8JGF | MRGX1 | MRGPRX1 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
bovine adrenal medul...
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41467-023-40705-Z | 2024-01-10 | |
| 8IYW | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
GSK256073
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.5 | Active | 10.1038/S41467-024-46239-2 | 2024-03-06 | |
| 3REY | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | vapour diffusion | Sitting drop | 6 chems | 8.0-8.8 | 4°C |
xanthine amine conge...
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 3.3 | Inactive | 10.1016/J.STR.2011.06.014 | 2011-09-07 | ||
| 8JGB | MRGX1 | MRGPRX1 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Conorfamide-Tx2
|
Agonist | 2.8 | Active | 10.1038/S41467-023-40705-Z | 2024-01-10 | |
| 5VEW | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.2-6.6 | 20°C |
PF-06372222
pubchem
|
NAM | 2.7 | Inactive | 10.1038/NATURE22378 | 2017-05-24 | |
| 3ZPQ | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 3 chems | 9.0-9.0 | 4°C |
CHEMBL200234
chembl_ligand
pubchem
|
Antagonist | 2.8 | Inactive | 10.1021/jm400140q | 2013-04-03 | ||
| 8WC6 | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-Phenylethanaminium
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | |
| 4LDL | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | 7.7 MAG | 5 chems | 6.5-6.5 | 20°C |
hydroxybenzylisoprot...
pubchem
|
Agonist | 3.1 | Active | 10.1038/NATURE12572 | 2013-09-25 | |
| 7SHF | GP158 | GPR158 | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.4 | Inactive | 10.1126/SCIENCE.ABL4732 | 2021-12-01 | |
| 4IAQ | 5HT1B | 5-HT1B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 8.7-8.7 | 20°C |
dihydroergotamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.8 | Inactive | 10.1126/SCIENCE.1232807 | 2013-03-13 | |
| 6WH4 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL428892
chembl_ligand
pubchem
|
Inverse agonist | 3.4 | Inactive | 10.1016/J.CELL.2020.08.024 | 2020-09-23 | |
| 7C4S | S1PR3 | S1P3 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
sphingosine 1-phosph...
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1126/SCIADV.ABF5325 | 2021-06-09 | |
| 8F7X | OPRX | NOP | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
nociceptin/orphanin ...
pubchem
gtoplig
chembl_ligand
gtoplig
pubchem
pubchem
|
Agonist | 3.3 | Active | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | |
| 7BB7 | V2R | V2 | Vasopressin and oxytocin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
vasopressin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 4.4 | Active | 10.1126/SCIADV.ABG5628 | 2021-06-02 | |
| 8XVL | EDNRA | ETA | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
zibotentan
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
|
Antagonist | 3.2 | Inactive | 2024-08-28 | ||
| 6M1I | PACR | PAC1 | VIP and PACAP | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[Ac-His<sup>1</sup>]...
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41422-020-0280-2 | 2020-03-11 | |
| 7VUI | GP139 | GPR139 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JNJ-63533054
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.3 | Active | 10.1038/S41422-021-00591-W | 2021-12-29 | |
| 8XBI | GPR34 | GPR34 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4758243
chembl_ligand
pubchem
|
Agonist | 3.1 | Active | 2023-12-27 | ||
| 9BKJ | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL216166
chembl_ligand
pubchem
|
Agonist | 2.6 | Active | 10.1371/JOURNAL.PBIO.3002673 | 2024-05-22 | |
| 8JCU | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 2.8 | Inactive | 10.1038/S41422-023-00830-2 | 2023-06-21 | |
| 5YC8 | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-methyl scopolamine
pubchem
gtoplig
drugbank
gtoplig
chembl_ligand
chembl_ligand
chembl_ligand
pubchem
pubchem
|
Antagonist | 2.5 | Inactive | 10.1038/S41589-018-0152-Y | 2018-11-21 | |
| 5GLH | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | Baculovirus | SF+ | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.0-6.0 | 20°C |
ENDOTHELIN
chembl_ligand
pubchem
|
Agonist | 2.8 | Inactive | 10.1038/nature19319 | 2016-09-07 | |
| 8FU6 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Glucagon derivative ...
|
Agonist | 2.9 | Active | 10.1016/J.CELL.2023.02.028 | 2023-04-12 | |
| 7TYF | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
amylin peptide
|
Agonist | 2.2 | Active | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | |
| 7VVK | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
teriparatide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
pubchem
pubchem
pubchem
pubchem
pubchem
|
Agonist | 3.3 | Active | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | |
| 7X9A | NPY1R | Y1 | Neuropeptide Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
neuropeptide Y
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
pubchem
pubchem
pubchem
|
Agonist | 3.2 | Active | 10.1126/SCIADV.ABM1232 | 2022-05-18 | |
| 5V54 | 5HT1B | 5-HT1B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 7.0-7.0 | 20°C |
CHEMBL428892
chembl_ligand
pubchem
|
Antagonist | 3.9 | Inactive | 2018-02-07 | ||
| 8HN1 | ADA1A | α1A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ρ-Da1a
gtoplig
pubchem
|
Antagonist | 2.9 | Inactive | 2023-12-20 | ||
| 8HK2 | C3AR | C3a | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
C3a anaphylatoxin
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41589-023-01339-W | 2023-05-10 | |
| 8WWM | MCHR1 | MCH1 | Melanin-concentrating hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Melanin-concentratin...
|
Agonist | 2.8 | Active | 10.1038/S41421-024-00754-0 | 2024-11-13 | |
| 8WZ2 | QRFPR | QRFP | Peptide P518 | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Orexigenic neuropept...
|
Agonist | 2.7 | Active | 10.1038/S41421-024-00670-3 | 2024-06-19 | |
| 9C1P | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R)-N-[2-(1,2-benzo...
pubchem
|
PAM | 2.8 | Inactive | 2024-10-02 | ||
| 6PS1 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
timolol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 3.2 | Inactive | 10.1107/S2052252519013137 | 2019-11-13 | |
| 8K3Z | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Stromal cell-derived...
|
Agonist | 2.8 | Active | 2024-07-17 | ||
| 8GH0 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 4.0 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 4XEE | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-8.0 | 20°C |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 2.9 | Active | 10.1038/NCOMMS8895 | 2015-07-29 | |
| 9CHV | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 4.0 | Intermediate | 10.1073/PNAS.2414544121 | 2024-11-13 | |
| 7C7Q | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(-)-baclofen
pubchem
gtoplig
chembl_ligand
drugbank
drugbank
gtoplig
pubchem
pubchem
BHFF pubchem |
AgonistPAM | 3.0 | Active | 2020-07-01 | ||
| 7T32 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 3.4 | Inactive | 10.1038/S41467-022-32125-2 | 2022-08-10 | |
| 7EJ0 | ADA2A | α2A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(-)-noradrenaline
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.2 | Active | 10.1126/SCIADV.ABJ5347 | 2022-04-13 | |
| 7EW0 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ozanimod
pubchem
gtoplig
drug_central
chembl_ligand
drugbank
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41422-021-00566-X | 2021-09-29 | |
| 7LCI | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
danuglipron
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 2021-01-20 | ||
| 7CFM | GPBAR | GPBA | Bile acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL2331646
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41586-020-2569-1 | 2020-09-09 | |
| 8HCQ | EDNRA | ETA | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ENDOTHELIN
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 2023-03-22 | ||
| 7YFC | HRH4 | H4 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
histamine
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
gtoplig
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41467-023-42260-Z | 2023-10-25 | |
| 7EPA | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.6 | Intermediate | 10.1038/S41586-021-03641-W | 2021-06-23 | |
| 6S0Q | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.7 | Inactive | 10.1107/S2052252520011379 | 2020-07-15 | |
| 7RKM | US28 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Fractalkine
pubchem
|
Agonist | 3.5 | Active | 10.1126/SCIADV.ABL5442 | 2022-01-26 | |
| 7JVP | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
39YLC3L0ZU
pubchem
|
Agonist | 2.9 | Active | 10.1016/J.CELL.2021.01.027 | 2021-02-24 | |
| 8W1V | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2S)-1-[(3-{1-[4-(4-...
|
Antagonist | 3.0 | Inactive | 2024-07-17 | ||
| 5XR8 | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | Transient_transfection | HEK293T | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.2-6.2 | 20°C |
AM841
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 10.1038/NATURE23272 | 2017-07-12 | |
| 3PQR | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 3 chems | 5.6-5.6 | 4°C |
Retinal (all-trans)
pubchem
|
Agonist | 2.9 | Active | 10.1038/NATURE09789 | 2011-03-09 | ||
| 8I95 | C3AR | C3a | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
EP54 ligand
|
Agonist | 2.9 | Active | 10.1016/J.CELL.2023.09.020 | 2023-10-18 | |
| 8IEI | GP156 | GPR156 | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2R)-3-[(E)-hexadec...
pubchem
|
Agonist | 2.6 | Inactive | 2024-02-14 | ||
| 5K2B | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.5 | Inactive | 10.1126/SCIADV.1600292 | 2016-09-21 | |
| 8IUM | PF2R | FP | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
tafluprost acid
pubchem
gtoplig
|
Agonist | 3.1 | Active | 10.1038/S41467-023-38411-X | 2023-07-12 | |
| 4QIM | SMO | SMO | Frizzled | F (Frizzled) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 7.2-7.2 | 20°C |
ANTA XV
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.6 | Inactive | 10.1038/NCOMMS5355 | 2014-07-23 | |
| 7TD3 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
sphingosine 1-phosph...
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41467-022-28417-2 | 2022-02-09 | |
| 7BU7 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1615159
chembl_ligand
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41422-020-00424-2 | 2020-12-02 | |
| 1F88 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 2 chemicals | 2 steps | vapour diffusion | Hanging drop | 7 chems | 6.0-6.0 | 4°C |
Retinal (11-cis)
pubchem
|
Inverse agonist | 2.8 | Inactive | 10.1126/SCIENCE.289.5480.739 | 2000-08-04 | ||
| 7WY8 | AGRL3 | ADGRL3 | ADGRL | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 10.1016/J.MOLCEL.2022.10.009 | 2022-10-26 | |
| 4MBS | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C |
maraviroc
pubchem
gtoplig
drugbank
chembl_ligand
gtoplig
chembl_ligand
chembl_ligand
pubchem
|
Antagonist | 2.7 | Inactive | 10.1126/SCIENCE.1241475 | 2013-09-11 | |
| 7Y3G | GPR12 | GPR12 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 10.1016/J.SCIB.2022.12.023 | 2023-06-07 | |
| 6U1N | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY2119620
pubchem
gtoplig
chembl_ligand
|
Agonist | 4.0 | Active | 10.1038/S41586-020-1954-0 | 2020-02-26 | |
| 8X5X | HRH1 | H1 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.5 | Inactive | 10.1038/S41467-023-44477-4 | 2024-01-17 | |
| 6WIV | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2R)-3-[(Z)-icos-11...
pubchem
(2R)-3-{[(S)-(2-amin... pubchem |
NAMNAM | 3.3 | Inactive | 10.1038/S41586-020-2452-0 | 2020-07-01 | |
| 7W7E | ADA2A | α2A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-(3-Bicyclo[4.2.0]o...
pubchem
|
Agonist | 3.4 | Active | 10.1126/SCIENCE.ABN7065 | 2022-09-28 | |
| 7MTQ | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 3.7 | Inactive | 10.1038/S41586-021-03680-3 | 2021-07-07 | |
| 8UNV | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7VVO | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Parathyroid hormone
|
Agonist | 4.1 | Active | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | |
| 9ERX | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
HU-210
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.9 | Active | 2024-06-26 | ||
| 8J19 | GPR84 | GPR84 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
6-nonylpyridine-2,4-...
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.2 | Active | 10.1038/S41467-023-38985-6 | 2023-06-21 | |
| 7WVY | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Amyloid beta-Peptide...
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41467-022-29361-X | 2022-04-13 | |
| 7T11 | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Octreotide
|
Agonist | 2.7 | Active | 10.1038/S41594-022-00727-5 | 2022-03-09 | |
| 9D3E | CCR6 | CCR6 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
OXM2
4-[[3,4-Dioxo-2-[[(1... pubchem |
AntagonistAllosteric antagonist | 3.0 | Inactive | 2024-09-11 | ||
| 7EVY | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
siponimod
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41422-021-00566-X | 2021-09-29 | |
| 6N52 | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 4.0 | Inactive | 10.1038/S41586-019-0881-4 | 2019-01-23 | |
| 8JH7 | FZD6 | FZD6 | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 10.1038/S41421-023-00627-Y | 2024-01-17 | |
| 8YKY | T2R14 | TAS2R14 | Taste 2 | T2 (Taste 2) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 28.1 [PMID:...
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 2024-07-10 | ||
| 8K6O | NPY1R | Y1 | Neuropeptide Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
neuropeptide Y
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
pubchem
pubchem
pubchem
|
Agonist | 3.3 | Active | 2024-07-31 | ||
| 8JPC | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4576388
chembl_ligand
pubchem
JMV431 gtoplig chembl_ligand pubchem |
PAMAgonist | 3.1 | Active | 10.1038/S41586-023-06395-9 | 2023-08-09 | |
| 8SZI | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-tryptophan
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem |
PAMAgonist | 3.5 | Active | 10.1038/S41586-024-07055-2 | 2024-02-07 | |
| 7F6I | BKRB2 | B2 | Bradykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
kallidin
pubchem
gtoplig
|
Agonist | 2.8 | Active | 10.1038/S41467-022-28399-1 | 2022-01-05 | |
| 8TLM | CCR8 | CCR8 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
mAb1
|
Antagonist | 2.9 | Inactive | 10.1038/S41467-023-43601-8 | 2023-12-20 | |
| 7X1T | TRFR | TRH1 | Thyrotropin-releasing hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
taltirelin
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.3 | Active | 10.1038/S41422-022-00646-6 | 2022-08-31 | |
| 8UO0 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8FYL | 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
vilazodone
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41586-024-07403-2 | 2024-05-15 | |
| 3RZE | HRH1 | H1 | Histamine | A (Rhodopsin) | Human | Pichia Pastoris | P. pastoris SMD1163 | Yeast | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 4.5-4.5 | 20-22°C |
doxepin
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
pubchem
|
Antagonist | 3.1 | Inactive | 10.1038/NATURE10236 | 2011-06-15 | |
| 8XOS | PAR1 | PAR1 | Proteinase-activated | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Tethered agonist
|
Agonist | 3.2 | Active | 2024-09-18 | ||
| 6KJV | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PF-06372222
pubchem
|
NAM | 2.8 | Inactive | 10.1107/S2052252519013496 | 2019-11-13 | |
| 8UNP | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7XK9 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL6913
chembl_ligand
pubchem
|
Agonist | 3.4 | Active | 2023-04-26 | ||
| 7DB6 | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ramelteon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41594-021-00634-1 | 2021-08-18 | |
| 7L0R | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 4.2 | Active | 10.1038/S41594-020-00554-6 | 2021-01-06 | |
| 6UVA | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
adrenomedullin 2/int...
gtoplig
|
Agonist | 2.3 | Active | 10.1021/ACSPTSCI.9B00080 | 2020-04-01 | |
| 9IJ9 | T2R14 | TAS2R14 | Taste 2 | T2 (Taste 2) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 28.1 [PMID:...
pubchem
gtoplig
chembl_ligand
Cholesterol pubchem |
Allosteric agonistAgonist | 2.7 | Active | 2024-07-24 | ||
| 5D5B | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.5-7.0 | 20°C |
Carazolol
pubchem
|
Inverse agonist | 3.8 | Inactive | 2016-01-13 | ||
| 8ID4 | FFAR4 | FFA4 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
linoleic acid
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 3.1 | Active | 10.1126/SCIENCE.ADD6220 | 2023-03-15 | |
| 7NA7 | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Ghrelin-27
|
Agonist | 2.7 | Active | 10.1038/S41467-021-26735-5 | 2021-12-15 | |
| 6UOA | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 6.3 | Intermediate | 10.1038/S41586-020-2408-4 | 2020-06-10 | |
| 7WBJ | VIPR2 | VPAC2 | VIP and PACAP | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PACAP-27
pubchem
gtoplig
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41467-022-30041-Z | 2022-05-18 | |
| 8HOC | HRH4 | H4 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
imetit
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 2023-12-20 | ||
| 6HLL | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CP 99994
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.3 | Inactive | 10.1038/S41467-018-07939-8 | 2019-01-16 | |
| 9AST | XCR1 | XCR1 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Lymphotactin
|
Agonist | 3.1 | Active | 10.1073/PNAS.2405732121 | 2024-12-11 | |
| 7KH0 | V2R | V2 | Vasopressin and oxytocin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
vasopressin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41422-021-00483-Z | 2021-05-26 | |
| 7VFX | FPR1 | FPR1 | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Peptide agonist fMet...
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-022-32822-Y | 2022-09-21 | |
| 8ZR5 | GP119 | GPR119 | GPR18, GPR55 and GPR119 | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
DS-8500a
pubchem
gtoplig
|
Agonist | 3.3 | Active | 2024-06-19 | ||
| 8JHI | FZD3 | FZD3 | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 2024-01-17 | ||
| 8GG5 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7SRQ | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Lysergide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.7 | Intermediate | 10.1016/J.NEURON.2022.08.006 | 2022-09-21 | |
| 8JLP | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ralmitaront
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.2 | Active | 10.1038/S41586-023-06804-Z | 2023-11-15 | |
| 2Y04 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 6 chems | 9.0-9.0 | 4°C |
levosalbutamol
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Agonist (partial) | 3.1 | Inactive | 10.1038/NATURE09746 | 2011-01-12 | ||
| 8GDB | PE2R4 | EP4 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PGE2
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 3.1 | Active | 10.1073/PNAS.2216329120 | 2024-01-10 | |
| 6KPF | CNR2 | CB2 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AM12033
pubchem
|
Agonist | 2.9 | Active | 2020-02-12 | ||
| 8JCV | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 3.4 | Inactive | 10.1038/S41422-023-00830-2 | 2023-06-21 | |
| 8IWM | TAAR9 | TAAR9 | A orphans | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-Phenylethanaminium
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41586-023-06106-4 | 2023-05-31 | |
| 5X33 | Q9WTK1 | BLT1 | Leukotriene | A (Rhodopsin) | Guinea pig | Pichia Pastoris | P. pastoris SMD1163 | Yeast | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 8.5-9.0 | 4°C |
BIIL 260
pubchem
gtoplig
|
Antagonist | 3.7 | Inactive | 10.1038/NCHEMBIO.2547 | 2018-01-03 | |
| 7RGP | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
tirzepatide
pubchem
gtoplig
|
Agonist | 2.9 | Active | 10.1073/PNAS.2116506119 | 2022-04-13 | |
| 8XOR | PAR1 | PAR1 | Proteinase-activated | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Tethered agonist
|
Agonist | 3.0 | Active | 2024-09-18 | ||
| 8JD3 | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JNJ-40411813
pubchem
gtoplig
chembl_ligand
drugbank
L-glutamic acid pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem |
PAMAgonist | 3.3 | Active | 10.1038/S41422-023-00830-2 | 2023-06-21 | |
| 7M3G | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
evocalcet
pubchem
gtoplig
drug_central
chembl_ligand
drugbank
pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem Calcium pubchem |
PAMPAMAgonist | 2.5 | Active | 10.1038/S41586-021-03691-0 | 2021-06-30 | |
| 8ID9 | FFAR4 | FFA4 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
EPA
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.0 | Active | 10.1126/SCIENCE.ADD6220 | 2023-03-15 | |
| 8XJO | TA2R | TP | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
U46619
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 3.1 | Active | 10.1016/J.CELREP.2024.113893 | 2024-02-28 | |
| 7FD8 | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
quisqualate
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
pubchem
|
Agonist | 3.8 | Active | 10.1016/J.CELREP.2021.109648 | 2021-09-08 | |
| 8X0C | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
quisqualate
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
pubchem
VU0424465 pubchem gtoplig chembl_ligand |
AgonistPAM | 3.2 | Active | 10.1038/S41467-024-55439-9 | 2024-11-06 | |
| 3UZA | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 6 chems | 8.0-8.0 | 4°C |
compound 4g [PMID: 2...
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.3 | Inactive | 10.1021/jm201376w | 2012-03-21 | ||
| 8YKW | SUCR1 | succinate | Succinate | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
succinic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41422-024-00984-7 | 2024-05-29 | |
| 8F7S | OPRD | δ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
DELTORPHIN II
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | |
| 7F1Z | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dopamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.5 | Active | 10.1126/SCIADV.ABO4158 | 2022-06-15 | |
| 8YNA | HRH4 | H4 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
immepip
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.6 | Active | 2024-10-09 | ||
| 8KFX | CCR8 | CCR8 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL5268017
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1126/SCIADV.ADJ7500 | 2024-02-07 | |
| 8UO1 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.6 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8IY9 | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
nicotinic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41467-024-46239-2 | 2024-03-06 | |
| 3AYM | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Japanese flying squid | NA | Native | Squid | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 5 chems | 6.6-6.6 | 4°C |
Retinal (all-trans)
pubchem
|
Agonist | 2.8 | Inactive | 10.1016/J.JMB.2011.08.044 | 2011-08-17 | ||
| 8HS3 | GPR20 | GPR20 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 10.1038/S41421-023-00520-8 | 2023-03-08 | |
| 8HK5 | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
C5a
gtoplig
|
Agonist | 3.0 | Active | 10.1038/S41589-023-01339-W | 2023-05-10 | |
| 8DPF | 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lorcaserin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.8 | Active | 10.1016/J.CELREP.2022.111211 | 2022-08-24 | |
| 8IWE | TAAR9 | TAAR9 | A orphans | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SPERMIDINE
chembl_ligand
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-023-06106-4 | 2023-05-31 | |
| 7EPC | GRM7 | mGlu7 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 4.0 | Inactive | 10.1038/S41586-021-03641-W | 2021-06-23 | |
| 3OE8 | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.0-6.0 | 20°C |
isothiourea-1t
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.1 | Inactive | 2010-10-27 | ||
| 8T3O | FFAR4 | FFA4 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
TUG-891
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.1 | Active | 10.1126/SCIADV.ADJ2384 | 2024-01-17 | |
| 7WVW | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
FME-TYR-PHE-ILE-ASN-...
|
Agonist | 3.1 | Active | 10.1038/S41467-022-29361-X | 2022-04-13 | |
| 7PIV | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
afamelanotide
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
pubchem
pubchem
pubchem
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41422-021-00569-8 | 2021-11-17 | |
| 7V9M | GHRHR | GHRH | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Somatoliberin
pubchem
|
Agonist | 3.3 | Active | 10.1073/PNAS.2106606118 | 2021-10-20 | |
| 7RMI | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 3.2 | Active | 10.1038/S41589-021-00890-8 | 2021-11-03 | |
| 6PGS | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Geraniol
pubchem
|
unknown | 2.9 | Active | 2020-07-01 | ||
| 8K9K | OPRM | μ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
DAMGO
pubchem
gtoplig
chembl_ligand
chembl_ligand
|
Agonist | 3.0 | Active | 10.1038/S41467-024-47792-6 | 2024-05-29 | |
| 8GGY | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.9 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 5VRA | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 4.6-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.4 | Inactive | 10.1038/NPROT.2017.135 | 2017-12-13 | |
| 7F8W | GASR | CCK2 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
desulfated gastrin-1...
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41589-021-00866-8 | 2021-10-13 | |
| 5YQZ | GLR | glucagon | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | MAG 7.8 | 5 chems | 8.0-8.0 | 20°C |
NNC1702
gtoplig
|
Agonist (partial) | 3.0 | Inactive | 10.1038/NATURE25153 | 2018-01-17 | |
| 8HQN | GP132 | GPR132 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
9-hydroxyoctadecadie...
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.0 | Active | 10.1038/S42255-023-00899-4 | 2023-10-11 | |
| 7VOD | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
cariprazine
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
chembl_ligand
pubchem
|
Agonist (partial) | 3.3 | Inactive | 10.1038/S41593-021-00971-W | 2021-12-22 | |
| 8TRD | GRM3 | mGlu3 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 3.4 | Inactive | 10.1038/S41467-024-50548-X | 2024-07-31 | |
| 6WWZ | CCR6 | CCR6 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCL20
gtoplig
|
Agonist | 3.3 | Active | 10.1038/S41467-020-16820-6 | 2020-06-24 | |
| 6NWE | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
B-Octylglucoside
pubchem
|
unknown | 2.7 | Active | 2020-02-12 | ||
| 7JVR | DRD2 | D2 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
bromocriptine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.8 | Active | 10.1016/J.CELL.2021.01.027 | 2021-02-24 | |
| 8JPP | SUCR1 | succinate | Succinate | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
succinic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41422-024-00968-7 | 2024-05-22 | |
| 8E9W | ACM3 | M3 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL73538
chembl_ligand
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41586-022-05489-0 | 2022-11-30 | |
| 8HIX | GPR21 | GPR21 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 10.1038/S41467-023-35882-W | 2023-03-15 | |
| 3KJ6 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 3 chemicals | 3 steps | vapour diffusion | bicelles | 5 chems | 7.5-7.5 | 298K |
Carazolol
pubchem
|
Inverse agonist | 3.4 | Inactive | 10.1038/NATURE08650 | 2010-02-16 | ||
| 5MZJ | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20 |
theophylline
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 2.0 | Inactive | 10.1016/j.str.2017.06.012 | 2017-07-26 | |
| 7EW3 | S1PR3 | S1P3 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Sphingosine 1-phosph...
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41422-021-00567-W | 2021-09-29 | |
| 6QNO | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (all-trans)
pubchem
|
Agonist | 4.4 | Active | 10.7554/ELIFE.46041 | 2019-07-10 | |
| 7CA5 | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 7.6 | Inactive | 10.1016/J.JMB.2020.09.023 | 2020-11-11 | |
| 9B9Y | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
taranabant
pubchem
gtoplig
chembl_ligand
drugbank
|
Inverse agonist | 3.5 | Inactive | 10.1038/S41467-024-54206-0 | 2024-11-20 | |
| 8GEF | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.8 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 6HLP | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
netupitant
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Antagonist | 2.2 | Inactive | 10.1038/S41467-018-07939-8 | 2019-01-16 | |
| 6Z66 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Intermediate | 10.1126/sciadv.abe5504 | 2021-02-10 | |
| 7XY6 | AA2BR | A2B | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
BAY 60-6583
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 10.1126/SCIADV.ADD3709 | 2023-05-03 | |
| 7XT8 | 5HT4R | 5-HT4 | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-hydroxytryptamine
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.1 | Active | 10.1016/J.MOLCEL.2022.05.031 | 2022-07-27 | |
| 8XZG | APJ | apelin | Apelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[Pyr<sup>1</sup>]ape...
gtoplig
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2024.02.004 | 2024-03-27 | |
| 5CGC | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-6.8 | 20°C |
CHEMBL3603915
chembl_ligand
pubchem
|
NAM | 3.1 | Inactive | 10.1021/acs.jmedchem.5b00892 | 2015-08-12 | |
| 7E2Z | 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
aripiprazole
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist (partial) | 3.1 | Active | 10.1038/S41586-021-03376-8 | 2021-04-14 | |
| 6FK8 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
(2~{R},3~{S})-3-azan...
pubchem
|
Agonist | 2.9 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
| 7E32 | 5HT1D | 5-HT1D | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-hydroxytryptamine
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.9 | Active | 10.1038/S41586-021-03376-8 | 2021-04-21 | |
| 8KFZ | CCR8 | CCR8 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.3 | Active | 10.1126/SCIADV.ADJ7500 | 2024-02-07 | |
| 4OO9 | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 6.8-6.8 | 20°C |
MAVOGLURANT
chembl_ligand
pubchem
drugbank
pubchem
|
NAM | 2.6 | Inactive | 10.1038/NATURE13396 | 2014-07-02 | |
| 6LN2 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PF-06372222
pubchem
|
NAM | 3.2 | Inactive | 10.1038/S41467-020-14934-5 | 2020-03-18 | |
| 7YDJ | AGRE5 | ADGRE5 | ADGRE | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.0 | Active | 2023-07-12 | ||
| 8GGZ | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.9 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7WKD | TRFR | TRH1 | Thyrotropin-releasing hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
TRH
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41422-022-00641-X | 2022-06-15 | |
| 7DUR | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-Tert-butyl-6,7-dic...
pubchem
|
Ago-PAM | 3.3 | Active | 10.1038/S41467-021-24058-Z | 2021-08-11 | |
| 8TR0 | GRM3 | mGlu3 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 3.2 | Inactive | 10.1101/2023.08.13.552748 | 2024-07-31 | |
| 8HDP | AA2BR | A2B | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
adenosine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41421-022-00503-1 | 2023-01-18 | |
| 6IBL | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ARFORMOTEROL
chembl_ligand
chembl_ligand
chembl_ligand
chembl_ligand
pubchem
drugbank
drugbank
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41586-020-2419-1 | 2019-01-09 | |
| 7FIH | LSHR | LH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-Amino-N-(1,1-dimet...
pubchem
Glycoprotein alpha gtoplig Choriogonadotropin b... gtoplig |
Allosteric agonistAgonistAgonist | 3.2 | Active | 10.1038/S41586-021-03924-2 | 2021-09-29 | |
| 7X1U | TRFR | TRH1 | Thyrotropin-releasing hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
TRH
pubchem
|
Agonist | 3.2 | Active | 2022-08-31 | ||
| 7PX4 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Preladenant conjugat...
pubchem
|
Antagonist | 2.3 | Inactive | 10.1002/ANIE.202115545 | 2022-03-02 | |
| 5XSZ | Q08BG4 | LPA6 | Lysophospholipid (LPA) | A (Rhodopsin) | Zebrafish | Baculovirus | Sf9 | Insect | 8 chemicals | 8 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 6 chems | 6.0-6.0 | 20°C |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 10.1038/NATURE23448 | 2017-08-16 | |
| 7VOE | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
aripiprazole
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist (partial) | 2.9 | Inactive | 10.1038/S41593-021-00971-W | 2021-12-22 | |
| 7FIY | GIPR | GIP | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
tirzepatide
pubchem
gtoplig
|
Agonist | 3.4 | Active | 10.1038/S41467-022-28683-0 | 2022-03-02 | |
| 5ZBH | NPY1R | Y1 | Neuropeptide Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL2046866
chembl_ligand
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/S41586-018-0046-X | 2018-04-25 | |
| 7WIH | GRM3 | mGlu3 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4081453
chembl_ligand
pubchem
|
Agonist | 3.7 | Active | 10.1038/S41422-022-00623-Z | 2022-03-16 | |
| 8WJX | P2RY1 | P2Y1 | P2Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ADP
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.2 | Active | 2024-10-02 | ||
| 8WA3 | GIPR | GIP | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1038/S41421-024-00649-0 | 2024-03-06 | |
| 8EJC | FFAR1 | FFA1 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
fasiglifam
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.0 | Active | 10.1073/PNAS.2219569120 | 2023-05-24 | |
| 7E9H | GRM4 | mGlu4 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-serine-O-phosphate
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 4.0 | Intermediate | 10.1038/S41586-021-03495-2 | 2021-06-23 | |
| 7KI0 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
semaglutide
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
chembl_ligand
pubchem
|
Agonist | 2.5 | Active | 10.1016/J.CELREP.2021.109374 | 2021-08-04 | |
| 4ZWJ | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Human | Transient_transfection | HEK293S(TetR)-GnTI- | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monopalmitolein (9.7 MAG) | 5 chems | 5.0-5.0 | 20°C |
Apo (no ligand)
|
Apo (no ligand) | 3.3 | Active | 10.1038/NATURE14656 | 2015-07-29 | |
| 8YRG | MRGX4 | MRGPRX4 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Fospropofol
pubchem
|
Agonist | 3.1 | Active | 2024-05-22 | ||
| 8XVH | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ENDOTHELIN
chembl_ligand
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41421-024-00705-9 | 2024-08-28 | |
| 8IOD | MC5R | MC5 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PG-901
pubchem
|
Agonist | 2.6 | Active | 10.1107/S0907444909042073 | 2023-09-20 | |
| 6D27 | PD2R2 | DP2 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL179036
chembl_ligand
pubchem
|
Antagonist | 2.7 | Inactive | 10.1016/J.MOLCEL.2018.08.009 | 2018-10-03 | |
| 7X2D | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
tavapadon
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41467-022-30929-W | 2022-06-15 | |
| 8U4O | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CXC12
|
Agonist | 3.3 | Active | 10.1038/S41594-024-01397-1 | 2024-03-13 | |
| 5YHL | PE2R4 | EP4 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ONO-AE3-208-Br
pubchem
|
Antagonist | 4.2 | Inactive | 10.1038/S41589-018-0131-3 | 2018-12-05 | |
| 7BU6 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Noradrenaline
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41422-020-00424-2 | 2020-12-02 | |
| 7SK5 | ACKR3 | ACKR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Stromal cell-derived...
|
Agonist | 4.0 | Active | 10.1126/SCIADV.ABN8063 | 2022-07-27 | |
| 7UL4 | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
alvimopan
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
|
Antagonist | 2.8 | Inactive | 10.1038/S41594-022-00859-8 | 2022-06-29 | |
| 7XBX | CX3C1 | CX3CR1 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CX3CL1
|
Agonist | 3.4 | Active | 2022-07-13 | ||
| 8J18 | GPR84 | GPR84 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(3R)-3-HYDROXYDODECA...
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41467-023-38985-6 | 2023-06-21 | |
| 6ME2 | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ramelteon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.8 | Inactive | 10.1038/S41586-019-1141-3 | 2019-04-24 | |
| 8F7R | OPRM | μ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
endomorphin-1
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.3 | Active | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | |
| 3EML | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.5-6.5 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.6 | Inactive | 10.1126/SCIENCE.1164772 | 2008-10-14 | |
| 5LWE | CCR9 | CCR9 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.9-8.0 | 20°C |
vercirnon
pubchem
gtoplig
chembl_ligand
drugbank
|
Allosteric antagonist | 2.8 | Inactive | 10.1038/NATURE20606 | 2016-12-07 | |
| 7TYX | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Amylin rat
pubchem
|
Agonist | 2.6 | Active | 10.1126/SCIENCE.ABM9609 | 2022-03-30 | |
| 8YZK | GPC5D | GPRC5D | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.4 | Inactive | 10.1038/S41467-024-49625-Y | 2024-07-03 | |
| 8Y52 | BRS3 | BB3 | Bombesin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Bombesin
|
Agonist | 2.9 | Active | 10.1016/J.CELREP.2024.114511 | 2024-09-11 | |
| 6ZFZ | ACM1 | M1 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3354065
chembl_ligand
pubchem
|
Agonist | 2.2 | Inactive | 10.1016/J.CELL.2021.11.001 | 2021-10-06 | |
| 7SQO | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
methyl (2R,3S)-3-[(m...
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41467-022-30601-3 | 2022-05-25 | |
| 7EVW | FZD7 | FZD7 | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 10.1038/S41422-021-00525-6 | 2021-08-04 | |
| 8JXS | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4277264
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.NEURON.2024.07.003 | 2024-09-04 | |
| 8XOI | GPER1 | GPER | Estrogen (G protein-coupled) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
fulvestrant
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.2 | Active | 10.1038/S41422-024-00963-Y | 2024-04-10 | |
| 7VGZ | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ramelteon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41467-022-28111-3 | 2022-03-02 | |
| 6RZ5 | CLTR1 | CysLT1 | Leukotriene | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
zafirlukast
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 2.5 | Active | 10.1126/SCIADV.AAX2518 | 2019-10-30 | |
| 7BW0 | GPBAR | GPBA | Bile acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 3.9 | Active | 10.1038/S41392-020-00262-Z | 2020-09-02 | |
| 7VVL | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
teriparatide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
pubchem
pubchem
pubchem
pubchem
pubchem
|
Agonist | 2.8 | Active | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | |
| 8FY8 | 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-MeO-DMT
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.8 | Active | 10.1038/S41586-024-07403-2 | 2024-05-15 | |
| 8PM2 | TAA7F | TAAR7F | A orphans | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N,N-Dimethylcyclohex...
pubchem
|
Agonist | 2.9 | Active | 10.1101/2023.07.07.547762 | 2023-08-09 | |
| 8IA7 | GASR | CCK2 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL216166
chembl_ligand
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41421-022-00420-3 | 2023-12-06 | |
| 7WCM | GP119 | GPR119 | GPR18, GPR55 and GPR119 | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MBX-2982
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.3 | Active | 10.1038/S41467-022-34696-6 | 2022-12-21 | |
| 5G53 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | vapour diffusion | Sitting drop | 6 chems | 5.7-5.7 | 4°C |
NECA
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 3.4 | Active | 10.1038/NATURE18966 | 2016-08-03 | ||
| 8XZI | APJ | apelin | Apelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CMF-019
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.7 | Active | 2024-03-20 | ||
| 6TP3 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
daridorexant
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
|
Antagonist | 3.0 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
| 7WU9 | PE2R3 | EP3 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.4 | Active | 10.1016/J.CELREP.2022.111323 | 2022-08-17 | |
| 8WVW | LGR4 | LGR4 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.5 | Inactive | 2024-10-30 | ||
| 6B73 | OPRK | κ | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 6.5-7.0 | 20°C |
CHEMBL5431513
chembl_ligand
pubchem
|
Agonist | 3.1 | Active | 10.1016/J.CELL.2017.12.011 | 2018-01-17 | |
| 8GGQ | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8XOJ | GPER1 | GPER | Estrogen (G protein-coupled) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 3.1 | Active | 10.1038/S41422-024-00963-Y | 2024-04-10 | |
| 8FN1 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 2.9 | Active | 10.1021/ACS.BIOCHEM.3C00029 | 2023-03-29 | |
| 3V2Y | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.8-7.8 | 20°C |
W146
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.8 | Inactive | 2012-02-15 | ||
| 5ZBQ | NPY1R | Y1 | Neuropeptide Y | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 7.4-8.0 | 19–22 °C |
CHEMBL3747822
chembl_ligand
chembl_ligand
chembl_ligand
pubchem
|
Antagonist | 2.7 | Inactive | 10.1038/S41586-018-0046-X | 2018-04-25 | |
| 7DD6 | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-tryptophan
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
Calcium pubchem |
PAMAgonist | 3.2 | Active | 10.1126/SCIADV.ABG1483 | 2021-06-16 | |
| 5UNH | AGTR2 | AT2 | Angiotensin | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 8.0-8.0 | 20°C |
compound 2 [PMID: 28...
pubchem
gtoplig
|
Antagonist | 2.9 | Active | 10.1038/NATURE22035 | 2017-04-05 | |
| 5VAI | G1SGD4 | GLP-1 | Glucagon | B1 (Secretin) | Rabbit | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | Cryo-EM | FEI, glow-discharged holey carbon grids | 7 chems | 7.5-7.5 | 20°C |
CHEMBL410972
chembl_ligand
pubchem
pubchem
|
Agonist | 4.1 | Active | 10.1038/NATURE22394 | 2017-05-24 | ||
| 8JLQ | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
fenoldopam
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
gtoplig
chembl_ligand
pubchem
pubchem
gtoplig
chembl_ligand
pubchem
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41586-023-06804-Z | 2023-11-15 | |
| 8ZH8 | QRFPR | QRFP | Peptide P518 | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
QRF-amide
|
Agonist | 3.2 | Active | 10.1038/S41467-024-49030-5 | 2024-07-03 | |
| 7WQ3 | GALR1 | GAL1 | Galanin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
galanin
pubchem
gtoplig
chembl_ligand
gtoplig
pubchem
pubchem
pubchem
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41467-022-29072-3 | 2022-04-20 | |
| 7XXH | P2RY1 | P2Y1 | P2Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2MeSADP
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 2.9 | Active | 2023-06-07 | ||
| 8IA8 | C3AR | C3a | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ALA-SER-LYS-LEU-GLY-...
|
Agonist | 2.9 | Active | 2023-05-24 | ||
| 6KPG | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AM841
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 2020-02-12 | ||
| 6MEO | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Envelope glycoprotei...
|
Antagonist | 3.9 | Inactive | 10.1038/S41586-018-0804-9 | 2018-12-12 | |
| 6IIV | TA2R | TP | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
daltroban
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.0 | Inactive | 10.1038/S41589-018-0170-9 | 2018-12-19 | |
| 8DWH | MRGX1 | MRGPRX1 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 16 [PMID: 3...
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.3 | Active | 10.1038/S41589-022-01173-6 | 2022-11-02 | |
| 8X17 | AA3R | A3 | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cl-IB-MECA
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41467-024-47207-6 | 2024-04-24 | |
| 5ZHP | ACM3 | M3 | Acetylcholine (muscarinic) | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(1R,2R,4S,5S,7s)-7-(...
pubchem
|
Antagonist | 3.1 | Inactive | 10.1073/PNAS.1813988115 | 2018-11-28 | |
| 8X7A | PI2R | IP | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
treprostinil
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.6 | Active | 10.1126/SCIADV.ADK5184 | 2024-03-06 | |
| 8GUR | CNR2 | CB2 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CP55940
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 2.8 | Active | 10.1038/S41467-023-37112-9 | 2023-05-10 | |
| 8J21 | FFAR3 | FFA3 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
butyric acid
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.3 | Active | 10.1038/S41422-023-00914-Z | 2024-01-24 | |
| 8ZRT | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ENDOTHELIN
chembl_ligand
pubchem
|
Agonist | 3.6 | Active | 10.1038/S42003-024-06905-Z | 2024-10-02 | |
| 7X8R | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL2158411
chembl_ligand
pubchem
|
Agonist | 2.6 | Active | 10.1073/PNAS.2200155119 | 2022-06-29 | |
| 8RLN | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL122622
chembl_ligand
pubchem
|
Agonist (partial) | 2.4 | Inactive | 2024-06-19 | ||
| 8U4N | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.7 | Active | 10.1038/S41594-024-01397-1 | 2024-03-13 | |
| 7KI1 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
taspoglutide
pubchem
gtoplig
drugbank
|
Agonist | 2.5 | Active | 10.1016/J.CELREP.2021.109374 | 2021-08-04 | |
| 3UZC | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 6 chems | 8.0-8.0 | 4°C |
CHEMBL2024114
chembl_ligand
pubchem
|
Antagonist | 3.3 | Inactive | 10.1021/jm201376w | 2012-03-21 | ||
| 7V3Z | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CP55940
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 3.3 | Active | 10.1021/JACS.1C06847 | 2021-11-24 | |
| 8DZR | OPRK | κ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL277863
chembl_ligand
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41586-023-06030-7 | 2023-05-03 | |
| 7XTA | 5HT4R | 5-HT4 | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-hydroxytryptamine
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.2 | Active | 10.1016/J.MOLCEL.2022.05.031 | 2022-07-27 | |
| 7FIM | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
tirzepatide
pubchem
gtoplig
|
Agonist | 3.4 | Active | 10.1038/S41467-022-28683-0 | 2022-03-02 | |
| 8EFB | OPRM | μ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
OLICERIDINE
chembl_ligand
pubchem
drugbank
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | |
| 7EPB | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
eglumegad
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 3.1 | Active | 10.1038/S41586-021-03641-W | 2021-06-23 | |
| 7YOO | NPY2R | Y2 | Neuropeptide Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
neuropeptide Y
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
pubchem
pubchem
pubchem
|
Agonist | 3.1 | Active | 10.1016/J.STR.2022.11.010 | 2023-03-22 | |
| 7L0P | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 4.1 | Active | 10.1038/S41594-020-00554-6 | 2021-01-06 | |
| 8F2A | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Pramlintide analogue...
|
Agonist | 2.2 | Active | 10.1038/S41589-023-01393-4 | 2023-08-02 | |
| 8ZMF | 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
1-[(4-Fluorophenyl)m...
pubchem
|
Inverse agonist | 3.6 | Inactive | 2024-08-28 | ||
| 6PH7 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Nerol
pubchem
|
unknown | 2.9 | Active | 2020-07-01 | ||
| 8TH3 | AGTR1 | AT1 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AT118-H Nanobody
|
Antagonist | 3.0 | Inactive | 10.1038/S41589-024-01620-6 | 2024-05-22 | |
| 5UZ7 | CALCR | CT | Calcitonin | B1 (Secretin) | Human | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | Cryo-EM | Volta phase plate (FEI) | 6 chems | 7.4-7.4 | cryoTemp(liquid Nitrogen) |
calcitonin (salmon s...
pubchem
chembl_ligand
pubchem
pubchem
|
Agonist | 4.1 | Active | 10.1038/NATURE22327 | 2017-05-03 | ||
| 7TRP | ACM4 | M4 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY2033298
pubchem
gtoplig
chembl_ligand
iperoxo pubchem gtoplig chembl_ligand |
PAMAgonist | 2.4 | Active | 2023-05-17 | ||
| 8ZPT | PRLHR | PrRP | Prolactin-releasing peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Prolactin-releasing ...
|
Agonist | 3.0 | Active | 10.1038/S41421-024-00724-6 | 2024-09-25 | |
| 8J20 | FFAR3 | FFA3 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(4R)-N-[2,5-bis(chlo...
pubchem
pentanoic acid pubchem gtoplig chembl_ligand drugbank |
PAMAgonist | 3.2 | Active | 10.1038/S41422-023-00914-Z | 2024-01-24 | |
| 8JLN | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1182312
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41586-023-06804-Z | 2023-11-15 | |
| 7UM7 | 5HT5A | 5-HT5A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
methylergonovine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41594-022-00796-6 | 2022-07-20 | |
| 7F6G | AGTR1 | AT1 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SAR1-AngII
|
Agonist | 2.9 | Active | 2023-03-29 | ||
| 7S0F | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LEVISOPRENALINE
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41594-021-00679-2 | 2021-11-17 | |
| 8WC3 | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ulotaront
pubchem
gtoplig
drugbank
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | |
| 5X7D | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 3 chemicals | 3 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 7.5-7.5 | 20°C |
4-carbamoyl-N-[(2R)-...
pubchem
Carazolol pubchem |
Allosteric antagonistAntagonist | 2.7 | Inactive | 10.1038/NATURE23652 | 2017-08-16 | |
| 6LFM | CXCR2 | CXCR2 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Interleukin-8
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-020-2492-5 | 2020-09-02 | |
| 8U4S | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
REGN7663 Fab heavy c...
|
Agonist | 3.4 | Active | 10.1038/S41594-024-01397-1 | 2024-03-13 | |
| 7TD1 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lysophosphatidic aci...
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41467-022-28417-2 | 2022-02-09 | |
| 8GG0 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 5DHG | OPRX | NOP | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.4-6.4 | 20°C |
CHEMBL1783826
chembl_ligand
pubchem
|
Antagonist | 3.0 | Inactive | 10.1016/J.STR.2015.07.024 | 2015-10-21 | |
| 8G2Y | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[1-Myristoyl-glycero...
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41467-023-38083-7 | 2023-05-10 | |
| 7F58 | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
THIQ
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.1 | Active | 10.1038/S41422-021-00552-3 | 2021-11-03 | |
| 8GGX | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.6 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7Y15 | MRGRD | MRGPRD | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1038/S42003-022-03668-3 | 2022-07-20 | |
| 8JBF | NK3R | NK3 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
senktide
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 10.1038/S41421-023-00564-W | 2024-02-28 | |
| 8WG9 | GRM4 | mGlu4 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-AP4
pubchem
gtoplig
chembl_ligand
gtoplig
pubchem
|
Agonist | 4.5 | Active | 2024-11-27 | ||
| 8CU6 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LJ-4517
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.8 | Inactive | 10.1021/acs.jmedchem.2c00462 | 2022-08-31 | |
| 8GE1 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8JXV | HRH4 | H4 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
clozapine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41467-024-46840-5 | 2024-03-20 | |
| 7XKD | AGRG2 | ADGRG2 | ADGRG | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PRASTERONE
chembl_ligand
pubchem
|
Agonist | 2.4 | Active | 10.1038/S41589-022-01084-6 | 2022-08-10 | |
| 8ID3 | FFAR4 | FFA4 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
9-Hydroxyoctadecanoi...
pubchem
|
Agonist | 3.1 | Active | 10.1126/SCIENCE.ADD6220 | 2023-03-15 | |
| 6WJC | ACM1 | M1 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
HYOSCYAMINE
chembl_ligand
pubchem
muscarinic toxin 7 gtoplig |
AntagonistNAM | 2.6 | Inactive | 10.1126/SCIENCE.AAX2517 | 2020-07-08 | |
| 8X0E | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
quisqualate
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41467-024-55439-9 | 2024-11-06 | |
| 6ME6 | MTR1B | MT2 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL15060
chembl_ligand
pubchem
|
Agonist | 2.8 | Inactive | 10.1038/S41586-019-1144-0 | 2019-04-24 | |
| 8WG8 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.7 | Active | 10.1038/S41421-024-00649-0 | 2024-03-06 | |
| 7F24 | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dopamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 4.2 | Active | 10.1126/SCIADV.ABO4158 | 2022-06-15 | |
| 8WC8 | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL476516
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | |
| 8IOC | MC3R | MC3 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
γ-MSH
pubchem
gtoplig
pubchem
|
Agonist | 2.9 | Active | 10.1107/S0907444909042073 | 2023-09-20 | |
| 7S8L | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cortistatin 14
pubchem
|
Agonist | 2.5 | Active | 10.1038/S41586-021-04126-6 | 2021-11-17 | |
| 4N6H | OPRD | δ | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 6.1-6.2 | 20-23°C |
naltrindole
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 1.8 | Inactive | 10.1038/NATURE12944 | 2013-12-25 | |
| 6TO7 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
suvorexant
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Antagonist | 2.3 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
| 8U4T | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
REGN7663 Fab heavy c...
|
Agonist | 3.4 | Inactive | 2024-03-13 | ||
| 6TOS | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL2413522
chembl_ligand
pubchem
|
Antagonist | 2.1 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-15 | |
| 6Z4Q | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SR142948A
pubchem
gtoplig
chembl_ligand
|
Inverse agonist | 2.9 | Inactive | 10.1126/sciadv.abe5504 | 2021-02-10 | |
| 7EPE | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3894759
chembl_ligand
pubchem
|
NAM | 2.5 | Inactive | 10.1038/S41586-021-03641-W | 2021-06-23 | |
| 8DPH | 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lorcaserin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.2 | Active | 10.1016/J.CELREP.2022.111211 | 2022-08-24 | |
| 8HTI | O52E4 | OR52E4 | Odorant family 52 | O1 (fish-like odorant) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
OCTANOIC ACID
chembl_ligand
pubchem
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41467-023-43983-9 | 2023-12-20 | |
| 8U4Q | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
REGN7663 Fab heavy c...
|
Agonist | 3.4 | Active | 10.1038/S41594-024-01397-1 | 2024-03-13 | |
| 7WU2 | AGRD1 | ADGRD1 | ADGRD | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 10.1038/S41586-022-04580-W | 2022-04-27 | |
| 2YDV | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 4 chemicals | 4 steps | vapour diffusion | sitting drop | 5 chems | 6.4-6.4 | 4°C |
NECA
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 2.6 | Active | 10.1038/NATURE10136 | 2011-05-18 | ||
| 2Y02 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 6 chems | 9.0-9.0 | 4°C |
CARMOTEROL
chembl_ligand
pubchem
pubchem
|
Agonist | 2.6 | Inactive | 2011-01-12 | |||
| 8GE7 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8WPU | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
cinacalcet
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
Calcium pubchem |
AgonistAgonist | 3.1 | Active | 10.1038/S41422-023-00892-2 | 2023-11-22 | |
| 8IEB | GP156 | GPR156 | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2R)-3-[(E)-hexadec...
pubchem
|
Agonist | 3.0 | Inactive | 2024-02-14 | ||
| 7YU5 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2~{R})-2-[5-(2-hex...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41467-022-33121-2 | 2022-10-05 | |
| 7YON | NPY2R | Y2 | Neuropeptide Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Peptide YY
|
Agonist | 3.0 | Active | 10.1016/J.STR.2022.11.010 | 2023-03-22 | |
| 6MH8 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 4.2 | Inactive | 10.1107/S205225251900263X | 2019-04-24 | |
| 9AYF | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cyclomethyltryptopha...
pubchem
tecalcet pubchem gtoplig chembl_ligand |
AgonistPAM | 3.6 | Active | 10.1038/S41586-024-07331-1 | 2024-04-17 | |
| 8IW4 | TAAR9 | TAAR9 | A orphans | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SPERMIDINE
chembl_ligand
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-023-06106-4 | 2023-05-31 | |
| 6AKY | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCR5 antagonist 34
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.8 | Inactive | 10.1021/acs.jmedchem.8b01077 | 2018-10-24 | |
| 8DZS | OPRK | κ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL277863
chembl_ligand
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41586-023-06030-7 | 2023-05-03 | |
| 8GH1 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 4.1 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7W0N | APJ | apelin | Apelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apelin receptor earl...
|
Agonist | 4.2 | Active | 10.1038/S41594-022-00797-5 | 2022-07-27 | |
| 6UUS | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Adrenomedullin
pubchem
|
Agonist | 2.4 | Active | 10.1021/ACSPTSCI.9B00080 | 2020-04-01 | |
| 6FUF | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (all-trans)
pubchem
|
Agonist | 3.1 | Active | 10.1126/SCIADV.AAT7052 | 2018-10-03 | |
| 6OIK | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY2119620
pubchem
gtoplig
chembl_ligand
iperoxo pubchem gtoplig chembl_ligand |
Ago-PAMAgonist | 3.6 | Active | 10.1126/SCIENCE.AAW5188 | 2019-05-08 | |
| 7JVQ | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
apomorphine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.CELL.2021.01.027 | 2021-02-24 | |
| 8JBG | NK3R | NK3 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
neurokinin B
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.8 | Active | 2024-02-07 | ||
| 8XVE | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
BQ3020
|
Agonist | 3.0 | Active | 10.1038/S41421-024-00705-9 | 2024-08-28 | |
| 5TZY | FFAR1 | FFA1 | Free fatty acid | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.3-6.8 | 20°C |
(2S,3R)-3-Cyclopropy...
pubchem
MK-8666 chembl_ligand pubchem |
PAMAgonist | 3.2 | Active | 10.1038/NSMB.3417 | 2017-06-07 | |
| 5K2C | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.9 | Inactive | 10.1126/SCIADV.1600292 | 2016-09-21 | |
| 8UNU | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7CKW | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
fenoldopam
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
gtoplig
chembl_ligand
pubchem
pubchem
gtoplig
chembl_ligand
pubchem
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | |
| 8X2K | GPR3 | GPR3 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-oleoylethanolamide
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 10.1038/S41422-023-00919-8 | 2024-04-03 | |
| 4O9R | SMO | SMO | Frizzled | F (Frizzled) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 7.4-7.4 | 20°C |
cyclopamine
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.2 | Inactive | 10.1038/NCOMMS4309 | 2014-03-05 | |
| 7WCN | GP119 | GPR119 | GPR18, GPR55 and GPR119 | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AR231453
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.9 | Active | 10.1038/S41467-022-34696-6 | 2022-12-21 | |
| 9EPQ | B1B1U5 | Rhodopsin | Opsins | A (Rhodopsin) | Hasarius adansoni | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
11,20-Ethanoretinal
pubchem
|
Agonist | 4.2 | Active | 2024-10-23 | ||
| 8XGO | KISSR | kisspeptin | Kisspeptin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
TAK448
|
Agonist | 2.7 | Active | 10.1126/SCIADV.ADN7771 | 2024-10-30 | |
| 2Y03 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 6 chems | 8.5-8.5 | 4°C |
LEVISOPRENALINE
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 2.9 | Inactive | 10.1038/NATURE09746 | 2011-01-12 | ||
| 8T6J | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CDPPB
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.5 | Inactive | 10.1101/2023.08.29.555158 | 2023-10-11 | |
| 8PWN | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
theophylline
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 2.4 | Inactive | 10.1038/S42004-023-01014-0 | 2023-10-25 | |
| 4DJH | OPRK | κ | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
JDTic
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.9 | Inactive | 10.1038/NATURE10939 | 2012-03-21 | |
| 6TPJ | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
suvorexant
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Antagonist | 2.7 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
| 8UNN | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8XXV | PD2R2 | DP2 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2~{R})-1-hexadecan...
|
PAM | 2.3 | Active | 2024-12-04 | ||
| 8DZP | OPRK | κ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SALVINORIN B METHOXY...
chembl_ligand
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41586-023-06030-7 | 2023-05-03 | |
| 7XP4 | T2R46 | TAS2R46 | Taste 2 | T2 (Taste 2) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.0 | Active | 10.1126/SCIENCE.ABO1633 | 2022-10-12 | |
| 8GUS | CNR2 | CB2 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL2179724
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41467-023-37112-9 | 2023-05-10 | |
| 9IMA | GPC5D | GPRC5D | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Talquetamab Fab ligh...
Talquetamab Fab heav... |
AntagonistAntagonist | 2.7 | Inactive | 10.1016/J.JMB.2024.168748 | 2024-09-11 | |
| 5F8U | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 1 chems | 3.6-4.0 | 18°C |
(S)-Cyanopindolol
pubchem
|
Antagonist | 3.4 | Inactive | 10.1038/NSMB.3130 | 2015-12-23 | ||
| 8UYQ | OR4D5 | OR4D5 | Odorant family 4 | O2 (tetrapod specific odorant) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2R)-2-methyl-1,3-th...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-024-08126-0 | 2024-10-30 | |
| 8HJ0 | GPR21 | GPR21 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 10.1038/S41467-023-35882-W | 2023-03-15 | |
| 4U16 | ACM3 | M3 | Acetylcholine (muscarinic) | A (Rhodopsin) | Rat | Baculovirus | Sf9 | Insect | 9 chemicals | 9 steps | sponge mesophase | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.5-7.5 | 298 K |
N-methyl scopolamine
pubchem
gtoplig
drugbank
gtoplig
chembl_ligand
chembl_ligand
chembl_ligand
pubchem
pubchem
|
Antagonist | 3.7 | Inactive | 10.1016/J.STR.2014.08.022 | 2014-11-26 | |
| 4UHR | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 4.8-4.8 | 22°C |
CGS 21680
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 2.6 | Active | 10.1124/mol.114.097360 | 2015-04-08 | |
| 8UNY | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.6 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7F55 | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
bremelanotide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.1 | Active | 2021-11-03 | ||
| 8XQP | T2R14 | TAS2R14 | Taste 2 | T2 (Taste 2) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
aristolochic acid
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.3 | Active | 10.1038/S41586-024-07569-9 | 2024-07-10 | |
| 7CFN | GPBAR | GPBA | Bile acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
INT-777
pubchem
INT-777 pubchem |
PAMAgonist | 3.0 | Active | 10.1038/S41586-020-2569-1 | 2020-09-09 | |
| 9IY8 | GPR55 | GPR55 | GPR18, GPR55 and GPR119 | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.0 | Active | 10.1038/S41422-024-01046-8 | 2025-01-01 | |
| 6WHC | GLR | glucagon | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Dual-agonist peptide...
|
Agonist | 3.4 | Active | 10.1074/JBC.RA120.013793 | 2020-05-27 | |
| 7VDL | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cortistatin 14
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41586-021-04077-Y | 2021-12-01 | |
| 8YN5 | HRH3 | H3 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
histamine
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
gtoplig
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41467-024-52585-Y | 2024-10-09 | |
| 4QKX | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | 7.7 MAG | 5 chems | 7.8-8.4 | 20°C |
Q27453560
pubchem
|
Agonist | 3.3 | Active | 10.1073/PNAS.1410415111 | 2014-07-23 | |
| 5OLV | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
CHEMBL1671936
chembl_ligand
pubchem
|
Antagonist | 2.0 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
| 8YN9 | HRH4 | H4 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
histamine
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
gtoplig
pubchem
|
Agonist | 2.3 | Active | 10.1038/S41467-024-52585-Y | 2024-10-09 | |
| 8JIU | GLR | glucagon | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SAR425899
|
Agonist | 2.8 | Active | 10.1073/PNAS.2303696120 | 2023-09-13 | |
| 8H0P | NMBR | BB1 | Bombesin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
NMB30
|
Agonist | 3.2 | Active | 10.1038/S41422-022-00743-6 | 2023-08-09 | |
| 7PYR | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Preladenant conjugat...
|
Antagonist | 2.6 | Inactive | 10.1002/ANIE.202115545 | 2022-03-02 | |
| 8X0B | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
quisqualate
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
pubchem
VU0424465 pubchem gtoplig chembl_ligand |
AgonistPAM | 3.1 | Active | 10.1038/S41467-024-55439-9 | 2024-11-06 | |
| 7PP1 | P2Y12 | P2Y12 | P2Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
selatogrel
pubchem
chembl_ligand
drugbank
pubchem
|
Antagonist | 2.8 | Active | 10.1016/j.bcp.2022.115291 | 2022-11-02 | |
| 1HZX | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 2 chemicals | 2 steps | vapour diffusion | Hanging drops | 7 chems | 6.0-6.0 | 4°C |
Retinal (11-cis)
pubchem
|
Inverse agonist | 2.8 | Inactive | 10.1021/BI0155091 | 2001-07-04 | ||
| 6QZH | CCR7 | CCR7 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL5433301
chembl_ligand
pubchem
|
Allosteric antagonist | 2.1 | Inactive | 10.1016/J.CELL.2019.07.028 | 2019-09-04 | |
| 7LD4 | AA1R | A1 | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
adenosine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-021-03897-2 | 2021-09-08 | |
| 6PWC | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL48981
chembl_ligand
pubchem
|
Agonist | 4.9 | Active | 10.1038/S41422-019-0256-2 | 2019-12-04 | |
| 7DD7 | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcium
pubchem
evocalcet pubchem gtoplig drug_central chembl_ligand drugbank pubchem L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem |
AgonistPAMPAM | 3.2 | Active | 10.1126/SCIADV.ABG1483 | 2021-06-16 | |
| 8K4P | Q76SF8 | ORF74 | Unclassified | A (Rhodopsin) | HHV-8 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 2024-07-24 | ||
| 7SK4 | ACKR3 | ACKR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Stromal cell-derived...
|
Agonist | 3.3 | Active | 10.1126/SCIADV.ABN8063 | 2022-07-27 | |
| 8HN8 | HRH4 | H4 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
histamine
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
gtoplig
pubchem
|
Agonist | 3.0 | Active | 2023-12-20 | ||
| 7X2C | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
fenoldopam
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
gtoplig
chembl_ligand
pubchem
pubchem
gtoplig
chembl_ligand
pubchem
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41467-022-30929-W | 2022-06-29 | |
| 7VVM | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Parathyroid hormone
|
Agonist | 3.2 | Active | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | |
| 7E2X | 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.0 | Active | 10.1038/S41586-021-03376-8 | 2021-04-14 | |
| 8WC9 | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL476516
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | |
| 8JIP | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MEDI0382
|
Agonist | 2.9 | Active | 10.1073/PNAS.2303696120 | 2023-09-06 | |
| 8JCY | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 2.9 | Inactive | 10.1038/S41422-023-00830-2 | 2023-06-21 | |
| 7EWL | GP158 | GPR158 | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.5 | Inactive | 10.1038/S41467-021-27147-1 | 2021-12-01 | |
| 7WYB | AGRL3 | ADGRL3 | ADGRL | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.0 | Active | 10.1016/J.MOLCEL.2022.10.009 | 2022-10-26 | |
| 8FLS | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
abaloparatide
pubchem
|
Agonist | 3.1 | Active | 10.1016/J.STR.2023.04.002 | 2023-04-26 | |
| 8ZRK | GP119 | GPR119 | GPR18, GPR55 and GPR119 | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
GSK-1292263
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 2024-06-19 | ||
| 7CKY | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3697578
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | |
| 8J6D | C3AR | C3a | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
EP141 peptide agonis...
|
Agonist | 3.1 | Active | 10.1016/J.CELL.2023.09.020 | 2023-10-18 | |
| 6WQA | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.0 | Inactive | 10.1107/S2052252520012701 | 2020-11-18 | |
| 7TRK | ACM4 | M4 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
iperoxo
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.8 | Active | 2023-05-17 | ||
| 7T9I | TSHR | TSH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Thyrotropin subunit ...
Glycoprotein hormone... |
AgonistAgonist | 2.9 | Active | 10.1038/S41586-022-05159-1 | 2022-08-03 | |
| 8I2G | FSHR | FSH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
FSHR agonist 1
pubchem
Follitropin subunit ... Glycoprotein alpha |
Allosteric agonistAgonistAgonist | 2.8 | Active | 10.1038/S41467-023-36170-3 | 2023-03-29 | |
| 6NI3 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1615159
chembl_ligand
pubchem
|
Agonist | 3.8 | Active | 10.1038/S41594-019-0330-Y | 2019-11-20 | |
| 7SRS | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Lysergide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.3 | Active | 10.1016/J.NEURON.2022.08.006 | 2022-09-21 | |
| 6PS5 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(-)-propranolol
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
gtoplig
chembl_ligand
drug_central
|
Antagonist | 2.9 | Inactive | 10.1107/S2052252519013137 | 2019-11-13 | |
| 8WCC | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cyclohexylammonium i...
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | |
| 8GFZ | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8GGJ | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8ID6 | FFAR4 | FFA4 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
oleic acid
pubchem
gtoplig
chembl_ligand
drug_central
|
Agonist | 2.8 | Active | 10.1126/SCIENCE.ADD6220 | 2023-03-15 | |
| 8KH5 | GP174 | GPR174 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Lysophosphotidylseri...
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-023-41654-3 | 2023-10-18 | |
| 7KNT | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Inactive | 10.1126/SCIENCE.ABF7258 | 2021-02-24 | |
| 8CXO | SMO | SMO | Frizzled | F (Frizzled) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cholesterol
pubchem
|
Agonist | 3.7 | Inactive | 10.1038/S41467-022-32125-2 | 2022-08-03 | |
| 8IHF | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MK 6892
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41467-023-41650-7 | 2023-08-30 | |
| 7T2H | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LOFENTANIL
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41589-022-01208-Y | 2022-12-07 | |
| 7M8W | PD2R2 | DP2 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
15(<i>R</i>)-15-meth...
pubchem
gtoplig
|
Antagonist | 2.6 | Inactive | 10.1073/PNAS.2102813118 | 2021-08-25 | |
| 6K1Q | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
IRL 2500
pubchem
gtoplig
chembl_ligand
|
Inverse agonist | 2.7 | Inactive | 10.1038/S42003-019-0482-7 | 2019-07-17 | |
| 3VGA | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | P.pastoris | P. pastoris SMD1163 | Yeast | 2 chemicals | 2 steps | vapour diffusion | hanging drop | 4 chems | 6.5-6.5 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 3.1 | Inactive | 10.1038/NATURE10750 | 2012-02-01 | ||
| 7X10 | AGRL3 | ADGRL3 | ADGRL | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1016/J.MOLCEL.2022.10.009 | 2022-11-09 | |
| 7XA3 | CCR2 | CCR2 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
C-C motif chemokine ...
|
Agonist | 2.9 | Active | 10.1038/S41421-022-00403-4 | 2022-08-24 | |
| 8JSP | 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ulotaront
pubchem
gtoplig
drugbank
chembl_ligand
pubchem
|
Agonist | 3.7 | Active | 10.1038/S41586-023-06804-Z | 2023-11-15 | |
| 8PJK | 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
6-[3-[2-(2-methoxyph...
pubchem
(2r)-1-(Heptadecanoy... pubchem |
AgonistPAM | 2.4 | Active | 2024-05-29 | ||
| 6B3J | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 2 chemicals | 2 steps | Cryo-EM | Volta phase plate (FEI) | 5 chems | 7.4-7.4 | 4°C |
Exendin-P5
|
Agonist | 3.3 | Active | 10.1038/NATURE25773 | 2018-02-21 | ||
| 6PB0 | CRFR1 | CRF1 | Corticotropin-releasing factor | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Urocortin
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.MOLCEL.2020.01.013 | 2020-02-12 | |
| 8XBE | GPR34 | GPR34 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4782438
chembl_ligand
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41467-024-45046-Z | 2024-05-15 | |
| 8EF6 | OPRM | μ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
morphine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | |
| 6PRZ | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1160734
chembl_ligand
pubchem
|
Antagonist | 2.8 | Inactive | 10.1107/S2052252519013137 | 2019-11-13 | |
| 7XW5 | TSHR | TSH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-[4-[[5-[(2S)-3-ben...
pubchem
Thyrotropin subunit ... Glycoprotein hormone... |
PAMAgonistAgonist | 3.0 | Active | 10.1038/S41586-022-05173-3 | 2022-08-24 | |
| 6TP4 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ACT-462206
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.0 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
| 7XJI | ADRB3 | β3 | Adrenoceptors | A (Rhodopsin) | Dog | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
3-[3-[2-[[(2~{S})-2-...
pubchem
|
Agonist | 3.9 | Active | 10.1016/J.BBRC.2022.04.065 | 2022-05-04 | |
| 8ZJE | KISSR | kisspeptin | Kisspeptin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ACY-DTY-HYP-ASN-THR-...
|
Agonist | 3.1 | Active | 2024-07-03 | ||
| 8QJ2 | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
pN162
|
Apo (no ligand) | 3.4 | Active | 2024-09-25 | ||
| 7VUH | GP139 | GPR139 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JNJ-63533054
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.2 | Active | 2021-12-29 | ||
| 8VHF | GP119 | GPR119 | GPR18, GPR55 and GPR119 | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MBX-2982
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.5 | Active | 2024-10-30 | ||
| 8U02 | DRD2 | D2 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dopamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41467-024-50964-Z | 2024-08-21 | |
| 8TZQ | DRD2 | D2 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dopamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41467-024-50964-Z | 2024-08-21 | |
| 8FMZ | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 2.6 | Active | 10.1021/ACS.BIOCHEM.3C00029 | 2023-03-29 | |
| 8JJP | CML2 | chemerin 2 | Chemerin receptor | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
chemerin C-terminal ...
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 2024-08-21 | ||
| 8IKG | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
3-[(1S)-1-(furan-2-y...
pubchem
|
Agonist | 3.4 | Active | 10.1073/PNAS.2321532121 | 2024-06-05 | |
| 6W25 | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SHU9119
pubchem
gtoplig
chembl_ligand
pubchem
Calcium pubchem |
AntagonistCofactor | 2.8 | Intermediate | 10.1126/SCIENCE.AAZ8995 | 2020-04-29 | |
| 6V9S | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JH112
pubchem
gtoplig
|
Antagonist | 3.5 | Inactive | 10.1073/PNAS.2002704117 | 2020-07-15 | |
| 6RZ6 | CLTR2 | CysLT2 | Leukotriene | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ONO-2570366
pubchem
gtoplig
|
Antagonist | 2.4 | Active | 10.1038/S41467-019-13348-2 | 2019-12-11 | |
| 6FKA | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
(2~{S})-2-(3,4-dichl...
pubchem
|
Agonist | 2.7 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
| 5WB1 | Q80KM9 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.0-6.0 | 16-20°C |
Apo (no ligand)
|
Apo (no ligand) | 3.5 | Active | 10.7554/ELIFE.35850 | 2018-06-13 | |
| 8FX5 | ACM4 | M4 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
xanomeline
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Agonist | 2.5 | Active | 10.1038/S41467-023-41199-5 | 2023-09-13 | |
| 8W8Q | GP101 | GPR101 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1038/S41589-023-01456-6 | 2024-01-03 | |
| 8U26 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 2.5 | Active | 10.1038/S41592-023-02082-9 | 2023-11-15 | |
| 8INR | MC5R | MC5 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
INTERMEDINE
chembl_ligand
pubchem
pubchem
pubchem
|
Agonist | 2.7 | Active | 10.1107/S0907444909042073 | 2023-09-20 | |
| 8GGC | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8X0D | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
quisqualate
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
pubchem
VU0424465 pubchem gtoplig chembl_ligand |
AgonistPAM | 3.5 | Active | 10.1038/S41467-024-55439-9 | 2024-11-06 | |
| 8GGP | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 2I36 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 2 chemicals | 2 steps | vapour diffusion | sitting drops | 5 chems | 7.0-8.0 | 5°C |
Apo (no ligand)
|
Apo (no ligand) | 4.1 | Inactive | 2006-10-17 | |||
| 7DGD | GRM1 | mGlu1 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 4.0 | Inactive | 10.1007/S13238-020-00808-5 | 2021-09-22 | |
| 7TD0 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lysophosphatidic aci...
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-022-28417-2 | 2022-02-09 | |
| 3P0G | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 8.0-8.0 | 20°C |
CHEMBL1615159
chembl_ligand
pubchem
|
Agonist | 3.5 | Active | 10.1038/NATURE09648 | 2011-01-19 | |
| 7YFD | HRH4 | H4 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
imetit
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41467-023-42260-Z | 2023-10-25 | |
| 8ZX4 | GPR55 | GPR55 | GPR18, GPR55 and GPR119 | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LPI
|
Agonist | 2.9 | Active | 2024-11-13 | ||
| 7EQ1 | AGRG5 | ADGRG5 | ADGRG | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.3 | Active | 10.1038/S41586-022-04619-Y | 2022-05-11 | |
| 7F23 | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dopamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.6 | Active | 10.1126/SCIADV.ABO4158 | 2022-06-15 | |
| 7WVV | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
synthetic peptide
|
Agonist | 2.9 | Active | 10.1038/S41467-022-29361-X | 2022-04-13 | |
| 5OLH | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
vipadenant
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.6 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
| 7XXI | P2Y12 | P2Y12 | P2Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2MeSADP
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 3.0 | Active | 2023-06-07 | ||
| 8EFL | OPRM | μ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4452384
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | |
| 8ZQE | GPR15 | GPR15 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
GPR15LG
|
Agonist | 2.9 | Active | 10.1038/S41421-024-00698-5 | 2024-07-10 | |
| 5OLG | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.9 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
| 6OS0 | AGTR1 | AT1 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
angiotensin II
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
pubchem
pubchem
|
Agonist | 2.9 | Active | 10.1126/SCIENCE.AAY9813 | 2020-02-19 | |
| 8IQ6 | PF2R | FP | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
latanoprost (free ac...
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.4 | Active | 10.1038/S41467-023-43922-8 | 2024-01-31 | |
| 8JIT | GLR | glucagon | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MEDI0382
|
Agonist | 2.9 | Active | 10.1073/PNAS.2303696120 | 2023-09-06 | |
| 7YIT | OPRK | κ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
nalfurafine
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 3.3 | Active | 10.1038/S41467-023-37041-7 | 2023-04-12 | |
| 6KUY | ADA2A | α2A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2~{S})-4-fluoranyl-...
pubchem
|
Agonist (partial) | 3.2 | Inactive | 2019-12-04 | ||
| 5UNF | AGTR2 | AT2 | Angiotensin | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 8.0-8.0 | 20°C |
compound 1 [PMID: 28...
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.8 | Active | 10.1038/NATURE22035 | 2017-04-05 | |
| 8XIO | SSR1 | SST1 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2S)-N-[(4S)-6-amino...
pubchem
|
Agonist | 2.7 | Active | 2024-07-03 | ||
| 7SK7 | ACKR3 | ACKR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Stromal cell-derived...
(1R)-4-[7-(3-carboxy... pubchem |
AgonistAgonist (partial) | 3.3 | Active | 10.1126/SCIADV.ABN8063 | 2022-07-27 | |
| 7F16 | PTH2R | PTH2 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
TIP39
gtoplig
|
Agonist | 2.8 | Active | 10.1073/PNAS.2101279118 | 2021-08-18 | |
| 8F7Q | OPRM | μ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
β-endorphin
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | |
| 7S1M | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
exendin-4
pubchem
gtoplig
pubchem
|
Agonist | 2.4 | Active | 10.1038/S41589-021-00945-W | 2022-01-05 | |
| 8UNR | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 5T1A | CCR2 | CCR2 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 6.5-6.5 | 20 °C. |
BMS-681
pubchem
gtoplig
chembl_ligand
CCR2-RA-[R] pubchem gtoplig chembl_ligand |
AntagonistAllosteric antagonist | 2.8 | Inactive | 10.1038/NATURE20605 | 2016-12-14 | |
| 7TYW | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
calcitonin (salmon s...
pubchem
chembl_ligand
pubchem
pubchem
|
Agonist | 3.0 | Active | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | |
| 7EB2 | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(-)-baclofen
pubchem
gtoplig
chembl_ligand
drugbank
drugbank
gtoplig
pubchem
pubchem
BHFF pubchem |
AgonistPAM | 3.5 | Active | 10.1038/S41586-021-03507-1 | 2021-05-05 | |
| 7SHE | GP158 | GPR158 | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.4 | Inactive | 10.1126/SCIENCE.ABL4732 | 2021-12-01 | |
| 7LD3 | AA1R | A1 | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
{2-Amino-4-[3,5-bis(...
pubchem
adenosine pubchem gtoplig chembl_ligand drugbank drug_central pubchem |
Ago-PAMAgonist | 3.2 | Active | 10.1038/S41586-021-03897-2 | 2021-09-08 | |
| 8J9O | FZD1 | FZD1 | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.4 | Active | 10.1038/S41421-023-00627-Y | 2024-01-17 | |
| 6LI0 | GPR52 | GPR52 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
derivative 17 [Nakah...
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.2 | Inactive | 10.1038/S41586-020-2019-0 | 2020-02-26 | |
| 6WHA | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL5184791
chembl_ligand
pubchem
|
Agonist | 3.4 | Active | 10.1016/J.CELL.2020.08.024 | 2020-09-23 | |
| 7VGY | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-iodo-melatonin
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.1 | Active | 10.1038/S41467-022-28111-3 | 2022-03-02 | |
| 6NBF | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Long-acting parathyr...
|
Agonist | 3.0 | Active | 10.1126/SCIENCE.AAV7942 | 2019-04-17 | |
| 8P13 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 5.2 | Active | 2024-11-20 | ||
| 5UVI | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 3.2 | Inactive | 10.1107/S205225251700570X | 2017-05-24 | |
| 6JZH | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.3 | Inactive | 10.1107/S1600576719012846 | 2019-10-30 | |
| 8GGS | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7S8P | MRGX4 | MRGPRX4 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-[(1r,3R,5S,7R)-3,5...
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41586-021-04126-6 | 2021-11-17 | |
| 8GGM | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7ZLY | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.7 | Active | 10.1038/S41467-023-37177-6 | 2023-04-12 | |
| 8GFX | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 2YCY | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | NA | 3 chems | 6.9-7.3 | NA |
(S)-Cyanopindolol
pubchem
|
Antagonist | 3.2 | Inactive | 10.1073/PNAS.1100185108 | 2011-06-08 | ||
| 8ZSP | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Lysergide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.1 | Active | 10.1016/J.CELREP.2024.114505 | 2024-07-24 | |
| 8H8J | GPR35 | GPR35 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lodoxamide
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 3.2 | Active | 10.1038/S41421-022-00499-8 | 2023-02-08 | |
| 8K9L | OPRM | μ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2~{S})-2-(3-bromany...
pubchem
DAMGO pubchem gtoplig chembl_ligand chembl_ligand |
PAMAgonist | 3.1 | Active | 10.1038/S41467-024-47792-6 | 2024-05-29 | |
| 8IJA | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
nicotinic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41421-023-00610-7 | 2024-01-03 | |
| 8IED | GP156 | GPR156 | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2R)-3-[(E)-hexadec...
pubchem
|
Agonist | 3.3 | Active | 2024-02-14 | ||
| 7VV3 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cortistatin 14
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41586-021-04077-Y | 2021-12-01 | |
| 7YDP | AGRE5 | ADGRE5 | ADGRE | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 10.1016/J.CHEMBIOL.2023.08.003 | 2023-07-12 | |
| 9EPR | B1B1U5 | Rhodopsin | Opsins | A (Rhodopsin) | Hasarius adansoni | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (11-cis)
pubchem
|
Agonist | 4.9 | Active | 10.1038/S41467-024-53208-2 | 2024-10-30 | |
| 8W8B | 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ulotaront
pubchem
gtoplig
drugbank
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41586-023-06775-1 | 2023-11-22 | |
| 7VKT | LT4R1 | BLT1 | Leukotriene | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LTB4
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.9 | Active | 10.1038/S41467-022-28820-9 | 2022-03-09 | |
| 8XZF | APJ | apelin | Apelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
WN561
|
Agonist | 3.0 | Active | 10.1016/J.CELL.2024.02.004 | 2024-03-20 | |
| 7E9G | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
eglumegad
pubchem
gtoplig
chembl_ligand
gtoplig
JNJ-40411813 pubchem gtoplig chembl_ligand drugbank |
AgonistPAM | 3.5 | Intermediate | 10.1038/S41586-021-03495-2 | 2021-06-23 | |
| 8HQC | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
C5a
gtoplig
|
Agonist | 3.9 | Active | HTTPS://DOI.ORG/10.1016/J.CELL.2023.09.020 | 2023-10-18 | |
| 7RBT | GIPR | GIP | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-fluoro-4-[(1R)-6-m...
pubchem
tirzepatide pubchem gtoplig |
PAMAgonist | 3.1 | Active | 10.1073/PNAS.2116506119 | 2022-04-13 | |
| 6KK7 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PF-06372222
pubchem
|
NAM | 3.1 | Inactive | 10.1107/S2052252519013496 | 2019-11-13 | |
| 8TQB | GRM3 | mGlu3 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY379268
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.3 | Active | 10.1101/2023.08.13.552748 | 2024-07-31 | |
| 7WI6 | GRM3 | mGlu3 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 3.7 | Inactive | 10.1038/S41422-022-00623-Z | 2022-03-16 | |
| 7T10 | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SOMATOSTATIN
chembl_ligand
pubchem
|
Agonist | 2.5 | Active | 10.1038/S41594-022-00727-5 | 2022-03-09 | |
| 8WWK | MCHR1 | MCH1 | Melanin-concentrating hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Melanin-concentratin...
|
Agonist | 2.6 | Active | 10.1038/S41421-024-00754-0 | 2024-11-13 | |
| 8ZCJ | SSR5 | SST5 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
004-DTR-LYS-TYR-PHA-...
|
Agonist | 3.1 | Active | 10.1038/S41401-024-01314-8 | 2024-07-10 | |
| 8A6C | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (11-cis)
pubchem
|
Agonist | 1.8 | Inactive | 10.1038/S41586-023-05863-6 | 2023-03-29 | |
| 2RH1 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.8-6.8 | 21-23°C |
Carazolol
pubchem
|
Inverse agonist | 2.4 | Inactive | 10.1126/SCIENCE.1150577 | 2007-10-30 | |
| 3OE6 | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20°C |
isothiourea-1t
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.2 | Inactive | 10.1126/SCIENCE.1194396 | 2010-10-27 | |
| 6X18 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL410972
chembl_ligand
pubchem
pubchem
|
Agonist | 2.1 | Active | 10.1016/J.MOLCEL.2020.09.020 | 2020-09-09 | |
| 8SMV | GP161 | GPR161 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.7 | Active | 10.1101/2023.05.23.540554 | 2024-02-21 | |
| 5DGY | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Human | Transient_transfection | HEK293S | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monopalmitolein (9.7 MAG) | 5 chems | 5.0-5.0 | 20°C |
Apo (no ligand)
|
Apo (no ligand) | 7.7 | Active | 10.1038/SDATA.2016.21 | 2016-03-23 | |
| 7VQX | VIPR2 | VPAC2 | VIP and PACAP | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PACAP-27
pubchem
gtoplig
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41467-022-30041-Z | 2022-05-18 | |
| 6OFJ | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 4.5 | Inactive | 10.1074/JBC.RA119.010089 | 2019-08-21 | |
| 6GPX | CCR2 | CCR2 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MK-0812
pubchem
|
Antagonist | 2.7 | Inactive | 10.1016/J.STR.2018.10.027 | 2019-01-02 | |
| 3V2W | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.8-7.8 | 20°C |
W146
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.4 | Inactive | 10.1126/SCIENCE.1215904 | 2012-02-15 | |
| 7TZF | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
amylin peptide
|
Agonist | 2.4 | Active | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | |
| 7EZK | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCK-8
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 3.1 | Active | 10.1038/S41589-021-00841-3 | 2021-08-25 | |
| 4IB4 | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 8.0-8.5 | 20°C |
ergotamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.7 | Intermediate | 10.1126/science.1232808 | 2013-03-13 | |
| 8JCX | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 3.0 | Inactive | 10.1038/S41422-023-00830-2 | 2023-06-21 | |
| 8IW7 | TAAR9 | TAAR9 | A orphans | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-Phenylethanaminium
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41586-023-06106-4 | 2023-05-31 | |
| 7DHR | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LEVISOPRENALINE
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 3.8 | Active | 2020-12-16 | ||
| 8WGD | GRM4 | mGlu4 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2S)-2-azanyl-2-cycl...
pubchem
|
Antagonist | 4.5 | Inactive | 2024-11-27 | ||
| 8XQR | T2R14 | TAS2R14 | Taste 2 | T2 (Taste 2) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
flufenamic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.2 | Active | 10.1038/S41586-024-07569-9 | 2024-07-10 | |
| 8XQL | T2R14 | TAS2R14 | Taste 2 | T2 (Taste 2) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
aristolochic acid
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 10.1038/S41586-024-07569-9 | 2024-07-10 | |
| 8GGL | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 5CXV | ACM1 | M1 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 8.0-8.0 | 20°C |
0HK
pubchem
|
Antagonist | 2.7 | Inactive | 10.1038/NATURE17188 | 2016-03-09 | |
| 8QW4 | FZD3 | FZD3 | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1038/S41467-024-51451-1 | 2024-09-04 | |
| 2R4S | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | vapour diffusion | hanging drop | 5 chems | 6.5-7.5 | 22°C |
Carazolol
pubchem
|
Inverse agonist | 3.4 | Inactive | 10.1038/NATURE06325 | 2007-11-06 | ||
| 7VBH | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Peptide 20
|
Agonist | 3.0 | Active | 10.1038/S41467-022-28683-0 | 2022-04-06 | |
| 8E0G | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
BU72
pubchem
gtoplig
pubchem
|
Agonist | 2.1 | Active | 10.1186/S12915-023-01689-W | 2023-10-18 | |
| 7XKA | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.1 | Active | 2023-04-26 | ||
| 8HS2 | GPR20 | GPR20 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 10.1038/S41421-023-00520-8 | 2023-03-08 | |
| 6PS4 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ICI 118551
pubchem
gtoplig
chembl_ligand
chembl_ligand
pubchem
|
Antagonist | 2.6 | Inactive | 10.1107/S2052252519013137 | 2019-11-13 | |
| 7WY0 | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 10.1038/S41467-022-33173-4 | 2022-09-28 | |
| 8T7H | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
quisqualate
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
pubchem
|
Agonist | 3.3 | Intermediate | 10.1101/2023.08.29.555158 | 2023-10-11 | |
| 6ZDV | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-Methyl-3-(4-methyl...
pubchem
|
Antagonist | 2.1 | Inactive | 10.1002/ANIE.202003788 | 2020-09-16 | |
| 9IVG | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL410972
chembl_ligand
pubchem
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.APSB.2024.09.002 | 2024-11-27 | |
| 6TQ9 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SB-408124
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.7 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
| 7EO2 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(S)-FTY720-phosphate
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.9 | Active | 10.1038/S41589-021-00930-3 | 2022-01-05 | |
| 8UXY | OR1F1 | OR1F1 | Odorant family 1 | O2 (tetrapod specific odorant) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
l-Menthol
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-024-08126-0 | 2024-10-30 | |
| 6RNK | SUCR1 | succinate | Succinate | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
NF-56-EJ40
pubchem
gtoplig
chembl_ligand
|
Antagonist | 1.9 | Active | 10.1038/S41586-019-1663-8 | 2019-08-14 | |
| 6KQI | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CP55940
pubchem
gtoplig
chembl_ligand
gtoplig
Org27569 pubchem gtoplig chembl_ligand |
AgonistNAM | 3.3 | Inactive | 10.1038/S41589-019-0387-2 | 2019-10-23 | |
| 8K2W | CXCR3 | CXCR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL397983
chembl_ligand
pubchem
|
Agonist | 3.0 | Inactive | 10.1038/S41421-023-00617-0 | 2023-11-29 | |
| 8GE4 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8GEI | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 4.1 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8IJD | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MK 6892
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41421-023-00610-7 | 2024-01-03 | |
| 8DCR | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Dobutamine
pubchem
|
Agonist (partial) | 2.6 | Active | 10.1038/S41467-022-31823-1 | 2022-07-27 | |
| 7WUI | AGRG2 | ADGRG2 | ADGRG | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
IP15
|
Agonist | 3.1 | Active | 10.1038/S41586-022-04590-8 | 2022-04-27 | |
| 7M3E | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
NPS 2143
pubchem
gtoplig
chembl_ligand
drugbank
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem Calcium pubchem |
NAMPAMAgonist | 3.2 | Inactive | 10.1038/S41586-021-03691-0 | 2021-06-30 | |
| 8JPF | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4576388
chembl_ligand
pubchem
JMV431 gtoplig chembl_ligand pubchem |
PAMAgonist | 3.0 | Active | 10.1038/S41586-023-06395-9 | 2023-08-09 | |
| 8I97 | C3AR | C3a | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 10.1016/J.CELL.2023.09.020 | 2023-10-18 | |
| 5IUB | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20°C |
CHEMBL184061
chembl_ligand
pubchem
|
Antagonist | 2.1 | Inactive | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | |
| 8FYE | 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL352186
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41586-024-07403-2 | 2024-05-15 | |
| 3CAP | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drop | 4 chems | 5.6-5.6 | 4°C |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1038/NATURE07063 | 2008-06-24 | ||
| 7DH5 | ADRB3 | β3 | Adrenoceptors | A (Rhodopsin) | Dog | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
mirabegron
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.MOLCEL.2021.06.024 | 2021-08-04 | |
| 7F2O | BKRB2 | B2 | Bradykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
bradykinin
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
|
Agonist | 2.9 | Active | 10.1038/S41594-021-00645-Y | 2021-10-13 | |
| 4ZJC | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.6-5.6 | 20°C |
SB-674042
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.8 | Inactive | 2016-03-09 | ||
| 7EIB | BKRB1 | B1 | Bradykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[des-Arg<sup>10</sup...
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 3.0 | Active | 10.1038/S41594-021-00645-Y | 2021-10-13 | |
| 7XAT | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SOMATOSTATIN
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41421-022-00405-2 | 2022-08-31 | |
| 7F8V | GASR | CCK2 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
desulfated gastrin-1...
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41589-021-00866-8 | 2021-10-13 | |
| 4K5Y | CRFR1 | CRF1 | Corticotropin-releasing factor | B1 (Secretin) | Human | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-5.5 | 22.5°C |
CP 376,395
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.0 | Inactive | 10.1038/NATURE12357 | 2013-07-17 | |
| 7LCJ | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
danuglipron
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 2021-01-20 | ||
| 5NM4 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.7 | Inactive | 10.1038/S41467-017-00630-4 | 2017-09-27 | |
| 8JLZ | 5HT6R | 5-HT6 | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL365751
chembl_ligand
pubchem
|
Agonist | 3.1 | Active | 10.1016/J.BBRC.2023.05.126 | 2023-06-28 | |
| 6FJ3 | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ePTH
|
Agonist (partial) | 2.5 | Inactive | 10.1038/S41594-018-0151-4 | 2018-11-21 | |
| 7XTC | 5HT7R | 5-HT7 | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-CT
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.2 | Active | 10.1016/J.MOLCEL.2022.05.031 | 2022-07-27 | |
| 7TS0 | CRFR2 | CRF2 | Corticotropin-releasing factor | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Urocortin
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-022-33851-3 | 2022-11-09 | |
| 7XBD | GALR2 | GAL2 | Galanin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Galanin, Human
pubchem
|
Agonist | 3.1 | Active | 10.1371/JOURNAL.PBIO.3001714 | 2022-07-13 | |
| 8UNZ | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.8 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 4XES | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.4 | 20°C |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 2.6 | Active | 10.1038/NCOMMS8895 | 2015-07-29 | |
| 6ZG4 | ACM1 | M1 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
HTL-9936
chembl_ligand
pubchem
|
Agonist | 2.3 | Inactive | 2021-10-06 | ||
| 8XFS | LGR4 | LGR4 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
R-spondin-2
|
Agonist | 3.2 | Inactive | 2024-12-04 | ||
| 6NIY | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
calcitonin (salmon s...
pubchem
chembl_ligand
pubchem
pubchem
|
Agonist | 3.3 | Active | 10.1021/ACSPTSCI.8B00056 | 2019-01-23 | |
| 7WZ7 | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 10.1038/S41467-022-33173-4 | 2022-09-28 | |
| 7DGE | GRM1 | mGlu1 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
quisqualate
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
pubchem
|
Agonist | 3.7 | Intermediate | 10.1007/S13238-020-00808-5 | 2021-09-22 | |
| 7UTZ | TSHR | TSH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Thyrotropin subunit ...
Glycoprotein hormone... |
AgonistAgonist | 2.4 | Active | 10.1038/S41586-022-05159-1 | 2022-08-03 | |
| 8K5D | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
GSK256073
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.7 | Active | 10.1038/S41467-023-42764-8 | 2023-11-22 | |
| 8YIC | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SAR247799
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.5 | Active | 2024-12-11 | ||
| 8UO3 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7XW7 | TSHR | TSH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
K1-70 scFv light cha...
K1-70 scFv heavy cha... |
AntagonistAntagonist | 5.5 | Inactive | 10.1038/S41586-022-05173-3 | 2022-08-17 | |
| 4RWS | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20°C |
vMIP-II
pubchem
gtoplig
|
Antagonist | 3.1 | Inactive | 10.1126/SCIENCE.1261064 | 2015-02-11 | |
| 8GFY | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 9IVM | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL410972
chembl_ligand
pubchem
pubchem
LSN3318839 pubchem gtoplig chembl_ligand |
AgonistPAM | 3.2 | Active | 2024-11-13 | ||
| 6DS0 | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY266097
pubchem
|
Antagonist | 3.2 | Intermediate | 10.1038/s41594-018-0116-7 | 2018-08-29 | |
| 7Y14 | MRGRD | MRGPRD | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
β-alanine
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
|
Agonist | 3.2 | Intermediate | 10.1038/S42003-022-03668-3 | 2022-07-20 | |
| 7F1T | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCL3
gtoplig
|
Agonist | 2.6 | Inactive | 2021-07-14 | ||
| 6ME3 | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL15060
chembl_ligand
pubchem
|
Agonist | 2.9 | Inactive | 10.1038/S41586-019-1141-3 | 2019-04-24 | |
| 7FIJ | LSHR | LH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.8 | Inactive | 10.1038/S41586-021-03924-2 | 2021-09-29 | |
| 7VIG | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
icanbelimod
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.9 | Active | 10.1073/PNAS.2117716119 | 2022-09-28 | |
| 4J4Q | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drop | 3 chems | 5.2-6.0 | 4°C |
B-Octylglucoside
pubchem
|
unknown | 2.7 | Active | 10.1002/ANIE.201302374 | 2013-10-30 | ||
| 7DTT | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcium
pubchem
|
Agonist | 3.8 | Active | 10.1038/S41422-021-00474-0 | 2021-03-10 | |
| 8WRZ | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AM841
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.6 | Active | 10.1093/PROCEL/PWAD055 | 2024-02-28 | |
| 8DWG | MRGX1 | MRGPRX1 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL5177388
chembl_ligand
pubchem
Proenkephalin-A |
PAMAgonist | 2.7 | Active | 10.1038/S41589-022-01173-6 | 2022-11-02 | |
| 8GGF | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.6 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7S3I | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
exendin-4
pubchem
gtoplig
pubchem
|
Agonist | 2.5 | Active | 10.1038/S41589-021-00945-W | 2022-01-05 | |
| 6Z8N | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2~{S})-4-methyl-2-[...
pubchem
|
Agonist | 2.8 | Intermediate | 10.1126/sciadv.abe5504 | 2021-02-10 | |
| 3VG9 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | P.pastoris | P. pastoris SMD1163 | Yeast | 2 chemicals | 2 steps | vapour diffusion | hanging drop | 4 chems | 6.5-6.5 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.7 | Inactive | 10.1038/NATURE10750 | 2012-02-01 | ||
| 7YU7 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2~{R})-2-[5-(2-hex...
pubchem
|
Agonist | 3.8 | Active | 10.1038/S41467-022-33121-2 | 2022-10-05 | |
| 7RAN | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
3-[(3R)-3-methyl-1,2...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-022-05258-Z | 2022-07-06 | |
| 4S0V | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 9 chemicals | 9 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.9-6.0 | 20°C |
suvorexant
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Antagonist | 2.5 | Inactive | 10.1038/NATURE14035 | 2015-01-14 | |
| 8EJK | FFAR1 | FFA1 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
fasiglifam
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.4 | Active | 10.1073/PNAS.2219569120 | 2023-05-24 | |
| 8GGT | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8HK3 | C3AR | C3a | Complement peptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 10.1038/S41589-023-01339-W | 2023-05-10 | |
| 8DWC | MRGX1 | MRGPRX1 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Proenkephalin-A
|
Agonist | 2.9 | Active | 10.1038/S41589-022-01173-6 | 2022-11-02 | |
| 7TYH | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcitonin human
pubchem
|
Agonist | 3.3 | Active | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | |
| 6JOD | AGTR2 | AT2 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
angiotensin II
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
pubchem
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.STR.2019.12.003 | 2020-01-15 | |
| 2PED | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drop | 5 chems | 6.4-6.4 | 283 K |
Retinal (9-cis)
pubchem
|
Inverse agonist | 3.0 | Inactive | 10.1529/BIOPHYSJ.107.108225 | 2007-10-30 | ||
| 7KNU | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcitonin gene-rela...
pubchem
|
Agonist | 3.5 | Inactive | 10.1126/SCIENCE.ABF7258 | 2021-02-24 | |
| 8XJM | PF2R | FP | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
latanoprost (free ac...
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.9 | Active | 10.1016/J.CELREP.2024.113893 | 2024-02-28 | |
| 8GDZ | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 9CHX | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Carazolol
pubchem
|
Inverse agonist | 3.5 | Intermediate | 10.1073/PNAS.2414544121 | 2024-11-13 | |
| 8JIL | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
nicotinic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 3.5 | Active | 10.1016/J.MOLCEL.2023.07.030 | 2023-09-06 | |
| 6RZ7 | CLTR2 | CysLT2 | Leukotriene | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ONO-2570366
pubchem
gtoplig
|
Antagonist | 2.4 | Active | 10.1038/S41467-019-13348-2 | 2019-12-11 | |
| 5ZK8 | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-methyl scopolamine
pubchem
gtoplig
drugbank
gtoplig
chembl_ligand
chembl_ligand
chembl_ligand
pubchem
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/S41589-018-0152-Y | 2018-11-21 | |
| 8JD2 | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-glutamic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41422-023-00830-2 | 2023-06-21 | |
| 6LPJ | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.8 | Inactive | 10.1038/S41598-020-76277-X | 2020-11-25 | |
| 7EPD | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.9 | Inactive | 10.1038/S41586-021-03641-W | 2021-06-23 | |
| 7C7S | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CGP 54626A
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 2.9 | Inactive | 10.1038/S41422-020-0350-5 | 2020-07-01 | |
| 7C61 | 5HT1B | 5-HT1B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ergotamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/S41598-020-68355-X | 2020-07-29 | |
| 8JHB | FZD6 | FZD6 | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.3 | Active | 10.1038/S41421-023-00627-Y | 2024-01-17 | |
| 8HNK | CXCR3 | CXCR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CXCL11
gtoplig
|
Agonist | 3.0 | Active | 10.1038/S41594-023-01175-5 | 2023-11-29 | |
| 4WW3 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Japanese flying squid | NA | Native | Squid | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 4 chems | 6.4-6.4 | 100-170 K |
Retinal (all-trans)
pubchem
|
Agonist | 2.8 | Inactive | 10.1371/JOURNAL.PONE.0126970 | 2015-06-17 | ||
| 8T1V | GPR6 | GPR6 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4763822
chembl_ligand
pubchem
|
Inverse agonist | 2.6 | Inactive | 10.1126/SCISIGNAL.ADO8741 | 2024-12-04 | |
| 8ZBE | SSR5 | SST5 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Octreotide
|
Agonist | 3.2 | Active | 10.1038/S41401-024-01314-8 | 2024-07-10 | |
| 8JRU | GLR | glucagon | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.5 | Active | 10.1038/S41586-023-06420-X | 2023-08-16 | |
| 8G59 | FFAR4 | FFA4 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
TUG-891
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.6 | Active | 10.1126/SCIENCE.ADD6220 | 2023-03-08 | |
| 6LI2 | GPR52 | GPR52 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Inactive | 10.1038/S41586-020-2019-0 | 2020-02-26 | |
| 6W2Y | GABR1 | GABAB1 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CGP55845
pubchem
1-Stearoyl-2-oleoyl-... pubchem |
Inverse agonistNAM | 3.2 | Inactive | 10.1038/S41586-020-2469-4 | 2020-07-01 | |
| 9EW2 | FZD7 | FZD7 | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 2024-10-02 | ||
| 8FN0 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4576388
chembl_ligand
pubchem
neurotensin pubchem gtoplig chembl_ligand gtoplig gtoplig |
PAMAgonist | 2.9 | Active | 10.1021/ACS.BIOCHEM.3C00029 | 2023-03-29 | |
| 4IAR | 5HT1B | 5-HT1B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.5-7.5 | 20°C |
ergotamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.7 | Inactive | 10.1126/SCIENCE.1232807 | 2013-03-13 | |
| 3PXO | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 3 chems | 5.0-5.8 | 4°C |
Retinal (all-trans)
pubchem
|
Agonist | 3.0 | Active | 10.1038/NATURE09789 | 2011-03-09 | ||
| 7SUS | APJ | apelin | Apelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(1R,2S)-N-[4-(2,6-di...
pubchem
|
Agonist | 2.7 | Inactive | 10.1038/S41594-022-00797-5 | 2022-07-27 | |
| 7Y24 | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Octreotide
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41589-022-01130-3 | 2022-10-19 | |
| 7BR3 | GNRHR | GnRH1 | Gonadotrophin-releasing hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
elagolix
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Antagonist | 2.8 | Inactive | 10.1038/S41467-020-19109-W | 2020-10-07 | |
| 5T04 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 8.5-9.0 | 20°C |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 3.3 | Active | 10.1038/SREP38564 | 2016-12-21 | |
| 8JBH | NK3R | NK3 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Protachykinin-1
|
Agonist | 2.9 | Active | 2024-02-07 | ||
| 4EA3 | OPRX | NOP | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.4-6.4 | 20°C |
compound 24 [PMID: 1...
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.0 | Inactive | 10.1038/NATURE11085 | 2012-04-25 | |
| 8X5Y | HRH1 | H1 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
astemizole
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Antagonist | 3.0 | Inactive | 10.1038/S41467-023-44477-4 | 2024-01-17 | |
| 5UIG | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | vapour diffusion | Sitting drop | 6 chems | 7.0-7.0 | 20°C |
5-Amino-N-[(2-Methox...
pubchem
|
Antagonist | 3.5 | Inactive | 10.1073/PNAS.1621423114 | 2017-02-08 | ||
| 5UEN | AA1R | A1 | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-8.0 | 20°C |
DU172
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.2 | Inactive | 10.1016/j.cell.2017.01.042 | 2017-03-01 | |
| 2HPY | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 5.9-6.1 | 283 K |
Retinal (all-trans)
pubchem
|
Agonist | 2.8 | Inactive | 10.1073/PNAS.0601765103 | 2006-08-22 | ||
| 7XWO | NK2R | NK2 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
HIS-LYS-THR-ASP-SER-...
|
Agonist | 2.7 | Active | 2023-05-31 | ||
| 7V6A | ACM4 | M4 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
methyl 4-[4-(3-methy...
pubchem
|
Allosteric agonist | 3.6 | Active | 10.1038/S41467-022-30595-Y | 2022-05-11 | |
| 9F33 | DRD3 | D3 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4551160
chembl_ligand
pubchem
|
Agonist | 3.1 | Active | 2024-09-18 | ||
| 7SIN | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
NPS 2143
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 5.9 | Inactive | 10.1073/PNAS.2115849118 | 2022-01-19 | |
| 8EA0 | ACM3 | M3 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
iperoxo
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.6 | Active | 10.1038/S41586-022-05489-0 | 2022-11-30 | |
| 8SAI | GPR34 | GPR34 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
O-[(S)-Hydroxy{[(2s)...
pubchem
|
Agonist | 3.3 | Active | 10.1073/PNAS.2308435120 | 2023-10-04 | |
| 7XZ5 | GP119 | GPR119 | GPR18, GPR55 and GPR119 | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(4R,7R,18E)-4,7-dihy...
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41594-022-00816-5 | 2022-08-24 | |
| 8GCP | PE2R4 | EP4 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PGE2
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
|
Agonist | 3.1 | Active | 10.1073/PNAS.2216329120 | 2024-01-03 | |
| 8HJ5 | MRGX1 | MRGPRX1 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 16 [PMID: 3...
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 2023-05-31 | ||
| 7BB6 | V2R | V2 | Vasopressin and oxytocin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
vasopressin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 4.2 | Active | 10.1126/SCIADV.ABG5628 | 2021-06-02 | |
| 8GEC | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7F4D | MSHR | MC1 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
INTERMEDINE
chembl_ligand
pubchem
pubchem
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41422-021-00557-Y | 2021-09-08 | |
| 9EPP | B1B1U5 | Rhodopsin | Opsins | A (Rhodopsin) | Hasarius adansoni | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
11,20-Ethanoretinal
pubchem
|
Agonist | 4.1 | Active | 2024-10-23 | ||
| 5OM1 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
CHEMBL2024114
chembl_ligand
pubchem
|
Antagonist | 2.1 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
| 4JKV | SMO | SMO | Frizzled | F (Frizzled) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 6 chems | 7.4-7.4 | 20°C |
taladegib
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
|
Antagonist | 2.5 | Inactive | 10.1038/NATURE12167 | 2013-04-24 | |
| 5TE3 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drop | 4 chems | 5.2-6.6 | 4°C |
B-Octylglucoside
pubchem
|
unknown | 2.7 | Active | 10.1073/PNAS.1617446114 | 2017-03-15 | ||
| 7Y12 | MRGRD | MRGPRD | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
β-alanine
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
|
Agonist | 3.1 | Active | 10.1038/S42003-022-03668-3 | 2022-07-20 | |
| 7VAB | GIPR | GIP | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
tirzepatide
pubchem
gtoplig
|
Agonist | 3.2 | Active | 10.1038/S41467-022-28683-0 | 2022-03-02 | |
| 6P9Y | PACR | PAC1 | VIP and PACAP | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[Ac-His<sup>1</sup>]...
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.MOLCEL.2020.01.012 | 2020-02-05 | |
| 7WZ4 | GPR88 | GPR88 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.0 | Active | 10.1038/S41467-022-30081-5 | 2022-10-26 | |
| 8UNO | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7S8O | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(R)-ZINC-3573
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.6 | Active | 10.1038/S41586-021-04126-6 | 2021-11-17 | |
| 8GGO | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7RA3 | GIPR | GIP | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
gastric inhibitory p...
pubchem
|
Agonist | 3.2 | Active | 10.1073/PNAS.2116506119 | 2022-04-13 | |
| 8XZJ | APJ | apelin | Apelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
WN353
|
Agonist | 3.0 | Active | 10.1016/J.CELL.2024.02.004 | 2024-03-20 | |
| 7WF7 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
sphingosine 1-phosph...
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41589-021-00930-3 | 2022-01-05 | |
| 8GTM | CRFR1 | CRF1 | Corticotropin-releasing factor | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
7-(4-bromanyl-2,6-di...
pubchem
|
Antagonist | 2.6 | Inactive | 10.1038/S12276-023-01082-1 | 2023-09-13 | |
| 8JWZ | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AB928
pubchem
gtoplig
chembl_ligand
pubchem
|
Antagonist | 2.4 | Inactive | 2023-08-16 | ||
| 8XVI | EDNRA | ETA | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ENDOTHELIN
chembl_ligand
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41421-024-00705-9 | 2024-08-28 | |
| 7W40 | GRPR | BB2 | Bombesin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Bombesin
|
Agonist | 3.0 | Active | 10.1073/PNAS.2216230120 | 2023-02-22 | |
| 8YNS | MCHR1 | MCH1 | Melanin-concentrating hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL242004
chembl_ligand
pubchem
|
Antagonist | 3.3 | Inactive | 2024-12-18 | ||
| 8JEF | HCAR3 | HCA3 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
3-hydroxyoctanoic ac...
pubchem
gtoplig
|
Agonist | 3.0 | Active | 10.1016/J.CELREP.2024.114895 | 2024-12-18 | |
| 7P00 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 2.7 | Active | 10.1126/SCIADV.ABK2872 | 2021-12-15 | |
| 7XTB | 5HT6R | 5-HT6 | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-hydroxytryptamine
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.3 | Active | 10.1016/J.MOLCEL.2022.05.031 | 2022-07-27 | |
| 8XQN | T2R14 | TAS2R14 | Taste 2 | T2 (Taste 2) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
aristolochic acid
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.1 | Active | 10.1038/S41586-024-07569-9 | 2024-07-10 | |
| 8YN2 | HRH1 | H1 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
histamine
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
gtoplig
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41467-024-52585-Y | 2024-10-09 | |
| 7BTS | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(-)-adrenaline
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41422-020-00424-2 | 2020-12-02 | |
| 4LDO | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | 7.7 MAG | 5 chems | 6.5-6.5 | 20°C |
(-)-adrenaline
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
|
Agonist | 3.2 | Active | 10.1038/NATURE12572 | 2013-09-25 | |
| 8DPG | 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
psilocin
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.6 | Active | 10.1016/J.CELREP.2022.111211 | 2022-08-24 | |
| 2I37 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 2 chemicals | 2 steps | vapour diffusion | sitting drops | 5 chems | 7.0-8.0 | 5°C |
Apo (no ligand)
|
Apo (no ligand) | 4.2 | Inactive | 10.1073/PNAS.0608022103 | 2006-10-17 | ||
| 8VY7 | T2R14 | TAS2R14 | Taste 2 | T2 (Taste 2) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 28.1 [PMID:...
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.7 | Active | 2024-04-03 | ||
| 4DKL | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | Baculovirus | Sf9 | Insect | 12 chemicals | 12 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C |
Methyl 4-[[(4R,4aS,7...
pubchem
|
Antagonist | 2.8 | Inactive | 10.1038/NATURE10954 | 2012-03-21 | |
| 6Z4S | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
meclinertant
pubchem
gtoplig
chembl_ligand
drugbank
|
Inverse agonist | 2.7 | Inactive | 10.1126/sciadv.abe5504 | 2021-02-10 | |
| 3UON | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.5-7.5 | 19.85°C |
CHEMBL558910
chembl_ligand
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/NATURE10753 | 2012-02-01 | |
| 7FD9 | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 4.0 | Inactive | 10.1016/J.CELREP.2021.109648 | 2021-09-08 | |
| 3OAX | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 6.0-6.0 | 283 K |
Retinal (11-cis)
pubchem
|
Inverse agonist | 2.6 | Inactive | 10.1016/J.BPJ.2010.08.003 | 2011-01-19 | ||
| 6OS9 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JMV449
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 10.1038/S41586-019-1337-6 | 2019-07-10 | |
| 7M3J | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
NPS 2143
pubchem
gtoplig
chembl_ligand
drugbank
|
NAM | 4.1 | Inactive | 10.1038/S41586-021-03691-0 | 2021-06-30 | |
| 8XGU | KISSR | kisspeptin | Kisspeptin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ACY-DTY-HYP-ASN-THR-...
|
Agonist | 3.0 | Active | 10.1126/SCIADV.ADN7771 | 2024-10-30 | |
| 7DTY | GIPR | GIP | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
GIP
pubchem
|
Agonist | 3.0 | Active | 10.7554/ELIFE.68719 | 2021-08-04 | |
| 8H0Q | GRPR | BB2 | Bombesin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Gastrin-releasing pe...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41422-022-00743-6 | 2023-08-09 | |
| 8JXW | HRH4 | H4 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL213912
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41467-024-46840-5 | 2024-03-20 | |
| 8ZSJ | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 10.1016/J.CELREP.2024.114505 | 2024-07-24 | |
| 3ZEV | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | NA | E. coli BL21(DE3) | Bacteria | 3 chemicals | 3 steps | vapour diffusion | sitting drops | 7 chems | 9.4-9.4 | 4°C |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 3.0 | Inactive | 10.1073/PNAS.1317903111 | 2014-01-29 | ||
| 8YW5 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retatrutide
|
Agonist | 2.8 | Active | 10.1038/S41421-024-00700-0 | 2024-08-07 | |
| 8E9Y | ACM3 | M3 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Clozapine N-oxide
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41586-022-05489-0 | 2022-11-30 | |
| 6H7O | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(S)-Cyanopindolol
pubchem
|
Agonist | 2.8 | Active | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | |
| 8WVU | LGR4 | LGR4 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
R-spondin-1
|
Agonist | 3.6 | Inactive | 2024-10-30 | ||
| 6ME8 | MTR1B | MT2 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL15060
chembl_ligand
pubchem
|
Agonist | 3.1 | Inactive | 10.1038/S41586-019-1144-0 | 2019-04-24 | |
| 7WC7 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lisuride
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.6 | Inactive | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | |
| 7VL9 | CCR1 | CCR1 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCL15(26-92)
|
Agonist | 2.6 | Active | 10.1038/S41589-021-00918-Z | 2022-03-23 | |
| 7XOU | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCK-8
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 3.2 | Active | 10.1038/S41421-022-00420-3 | 2022-07-20 | |
| 8K4O | Q76SF8 | ORF74 | Unclassified | A (Rhodopsin) | HHV-8 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Growth-regulated alp...
|
Agonist | 3.0 | Active | 2024-07-24 | ||
| 8XJK | PF2R | FP | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
cloprostenol
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.6 | Active | 2024-02-28 | ||
| 8XQS | T2R14 | TAS2R14 | Taste 2 | T2 (Taste 2) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
flufenamic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.3 | Active | 10.1038/S41586-024-07569-9 | 2024-07-10 | |
| 8XIR | SSR3 | SST3 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
004-DTR-LYS-TY5-PHE-...
|
Agonist | 2.5 | Active | 2024-07-03 | ||
| 7U2L | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-(5-carbamimidamido...
|
Agonist | 3.2 | Active | 10.1038/S41586-022-05588-Y | 2022-05-04 | |
| 7DW9 | V2R | V2 | Vasopressin and oxytocin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
vasopressin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41422-021-00480-2 | 2021-07-21 | |
| 7WU4 | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.4 | Active | 10.1038/S41586-022-04580-W | 2022-04-27 | |
| 7O7F | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCL5
gtoplig
|
Agonist | 3.2 | Active | 10.1126/SCIADV.ABG8685 | 2021-06-30 | |
| 5D6L | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C |
Carazolol
pubchem
|
Inverse agonist | 3.2 | Inactive | 10.1038/NPROT.2017.057 | 2016-08-17 | |
| 3SN6 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | sponge mesophase | lipidic cubic phase (LCP) | 7.7 MAG | 6 chems | 6.5-6.5 | 20°C |
CHEMBL1615159
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1038/NATURE10361 | 2011-07-20 | |
| 8GUT | CNR2 | CB2 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
1-[[4-[5-Fluoro-6-[(...
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41467-023-37112-9 | 2023-05-10 | |
| 8E3Y | VIPR1 | VPAC1 | VIP and PACAP | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[Ac-His<sup>1</sup>]...
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.3 | Active | 10.1038/S41467-022-34629-3 | 2022-11-23 | |
| 8HQM | GP132 | GPR132 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3354065
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1038/S42255-023-00899-4 | 2023-10-11 | |
| 8E3Z | VIPR1 | VPAC1 | VIP and PACAP | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Vasoactive intestina...
pubchem
chembl_ligand
pubchem
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41467-022-34629-3 | 2022-11-23 | |
| 8YN8 | HRH3 | H3 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
proxyfan
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.8 | Active | 2024-10-16 | ||
| 7TYO | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcitonin human
pubchem
|
Agonist | 2.7 | Active | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | |
| 6UP7 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JMV431
gtoplig
chembl_ligand
pubchem
|
Agonist | 4.2 | Active | 10.1038/S41586-020-1953-1 | 2020-02-26 | |
| 5WS3 | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 9 chemicals | 9 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.8-6.2 | 20°C |
EMPA
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.3 | Inactive | 10.1016/J.STR.2017.11.005 | 2017-12-13 | |
| 7F53 | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
α-MSH
pubchem
gtoplig
|
Agonist | 3.0 | Active | 2021-11-03 | ||
| 8DU3 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL5206530
chembl_ligand
pubchem
|
Antagonist | 2.5 | Inactive | 10.1016/j.ejmech.2022.114620 | 2022-08-10 | |
| 6LI3 | GPR52 | GPR52 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.3 | Active | 10.1038/S41586-020-2019-0 | 2020-02-26 | |
| 6N48 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-[[(3R)-4-(4-Tert-b...
pubchem
CHEMBL1615159 chembl_ligand pubchem |
PAMAgonist | 3.2 | Active | 10.1126/SCIENCE.AAW8981 | 2019-06-26 | |
| 8GGK | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8XJN | TA2R | TP | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
cloprostenol
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.1 | Active | 2024-02-28 | ||
| 5OM4 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
CHEMBL2024114
chembl_ligand
pubchem
|
Antagonist | 2.0 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
| 7TUZ | GP183 | GPR183 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2S,4aS,4bS,7R,8S,8a...
pubchem
|
Agonist | 3.1 | Active | 10.1016/J.STR.2022.04.006 | 2022-04-13 | |
| 8H4L | FFAR4 | FFA4 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
docosahexaenoic acid
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41422-023-00835-X | 2023-06-21 | |
| 8HNM | CXCR3 | CXCR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL2220409
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41594-023-01175-5 | 2023-11-29 | |
| 8UNX | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.6 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7XAU | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Octreotide
|
Agonist | 3.0 | Active | 10.1038/S41421-022-00405-2 | 2022-08-31 | |
| 2Y01 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 6 chems | 9.0-9.0 | 4°C |
Dobutamine
pubchem
|
Agonist (partial) | 2.6 | Inactive | 10.1038/NATURE09746 | 2011-03-30 | ||
| 8GD9 | PE2R4 | EP4 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
4-({2-[(1R,2R,3R,5S)...
pubchem
|
Agonist | 3.2 | Active | 10.1073/PNAS.2216329120 | 2024-01-10 | |
| 7W56 | NMUR1 | NMU1 | Neuromedin U | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Neuromedin-S
|
Agonist | 2.9 | Active | 10.1038/S41467-022-29683-W | 2022-04-20 | |
| 8FD1 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 4.3 | Inactive | 10.1038/S41467-023-40911-9 | 2023-08-30 | |
| 7XBW | CX3C1 | CX3CR1 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 10.1126/SCIADV.ABN8048 | 2022-07-13 | |
| 8JLO | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ulotaront
pubchem
gtoplig
drugbank
chembl_ligand
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-023-06804-Z | 2023-11-15 | |
| 8IKH | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
3-[(1R)-1-(2-methoxy...
pubchem
|
Agonist | 3.3 | Active | 10.1073/PNAS.2321532121 | 2024-06-05 | |
| 8WG7 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.5 | Active | 10.1038/S41421-024-00649-0 | 2024-03-06 | |
| 8IEP | GP156 | GPR156 | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2R)-3-[(E)-hexadec...
pubchem
|
Agonist | 2.6 | Inactive | 2024-02-14 | ||
| 6H7J | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LEVISOPRENALINE
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | |
| 6ZA8 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL508044
chembl_ligand
pubchem
|
Agonist (partial) | 2.7 | Intermediate | 10.1126/sciadv.abe5504 | 2021-02-10 | |
| 7FIN | GIPR | GIP | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Peptide-20
|
Agonist | 3.1 | Active | 10.1038/S41467-022-28683-0 | 2022-02-23 | |
| 6OIJ | ACM1 | M1 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
iperoxo
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.3 | Active | 10.1126/SCIENCE.AAW5188 | 2019-05-08 | |
| 7V69 | ACM4 | M4 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.4 | Active | 2022-05-11 | ||
| 4Z35 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.5-5.5 | 20°C |
ONO-9910539
pubchem
gtoplig
|
Antagonist | 2.9 | Inactive | 10.1016/J.CELL.2015.06.002 | 2015-06-03 | |
| 8IYX | GPR34 | GPR34 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
YL-365
pubchem
gtoplig
|
Antagonist | 3.3 | Active | 10.1073/PNAS.2308435120 | 2024-03-20 | |
| 7ZI0 | SMO | SMO | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
3-chloro-N-[trans-4-...
pubchem
|
Antagonist | 3.0 | Inactive | 10.1126/SCIADV.ABM5563 | 2022-06-15 | |
| 7E2Y | 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-hydroxytryptamine
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.0 | Active | 10.1038/S41586-021-03376-8 | 2021-04-14 | |
| 8TB0 | GPR61 | GPR61 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.5 | Active | 2023-10-04 | ||
| 7MBX | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL216166
chembl_ligand
pubchem
|
Agonist | 2.0 | Active | 10.1371/JOURNAL.PBIO.3001295 | 2021-05-26 | |
| 8J6R | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MK 6892
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-023-43537-Z | 2023-12-06 | |
| 8WW2 | GPR3 | GPR3 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
oleic acid
pubchem
gtoplig
chembl_ligand
drug_central
|
Agonist | 2.8 | Active | 10.1038/S41422-024-00932-5 | 2024-02-14 | |
| 8WCB | TAAR1 | TA1 | Trace amine | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cyclohexylammonium i...
pubchem
|
Agonist | 3.1 | Active | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | |
| 8XGM | CML2 | chemerin 2 | Chemerin receptor | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinoic acid recept...
|
Agonist | 3.3 | Active | 2024-08-21 | ||
| 7C2E | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-[[4-[6-[(4-cyano-2...
pubchem
|
Agonist | 4.2 | Active | 10.1038/S41422-020-0384-8 | 2020-08-26 | |
| 6DRZ | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
methysergide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 3.1 | Intermediate | 10.1038/s41594-018-0116-7 | 2018-08-29 | |
| 8H4K | FFAR4 | FFA4 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
GW9508
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.1 | Active | 10.1038/S41422-023-00835-X | 2023-06-21 | |
| 6BQG | 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
ergotamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.0 | Active | 10.1016/j.cell.2018.01.001 | 2018-02-14 | |
| 7W57 | NMUR2 | NMU2 | Neuromedin U | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Neuromedin-S
|
Agonist | 3.2 | Active | 10.1038/S41467-022-29683-W | 2022-04-20 | |
| 8JHN | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
monomethyl fumarate
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.8 | Active | 10.1038/S41467-024-46239-2 | 2024-03-06 | |
| 7W53 | NMUR1 | NMU1 | Neuromedin U | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Neuromedin U-25 (hum...
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41467-022-29683-W | 2022-04-20 | |
| 6RZ8 | CLTR2 | CysLT2 | Leukotriene | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ONO-2080365
pubchem
|
Antagonist | 2.7 | Active | 10.1038/S41467-019-13348-2 | 2019-12-11 | |
| 8ID8 | FFAR4 | FFA4 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
TUG-891
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 10.1126/SCIENCE.ADD6220 | 2023-03-15 | |
| 7Y26 | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Octreotide
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41589-022-01130-3 | 2022-10-19 | |
| 5WF6 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-5.0 | 20°C |
UK-432,097
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.9 | Active | 10.1016/J.STR.2017.12.013 | 2018-02-21 | |
| 6TPK | OXYR | OT | Vasopressin and oxytocin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
retosiban
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 3.2 | Inactive | 10.1126/SCIADV.ABB5419 | 2020-08-05 | |
| 8GG4 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8IC0 | CXCR1 | CXCR1 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Interleukin-8
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41467-023-39799-2 | 2023-07-19 | |
| 7V35 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Peptide-20
|
Agonist | 3.4 | Active | 10.1038/S41467-022-28683-0 | 2022-03-02 | |
| 4Z36 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.5-5.5 | 20°C |
ONO-3080573
pubchem
gtoplig
|
Antagonist | 2.9 | Inactive | 10.1016/J.CELL.2015.06.002 | 2015-06-03 | |
| 8IZB | GP174 | GPR174 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LYSOPHOSPHATIDIC ACI...
chembl_ligand
pubchem
L-serine pubchem gtoplig chembl_ligand drugbank drug_central pubchem |
AgonistAgonist | 3.1 | Active | 10.1371/JOURNAL.PBIO.3002387 | 2023-11-01 | |
| 8GFV | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8WRB | GPR34 | GPR34 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LYSOPHOSPHATIDIC ACI...
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 10.1371/JOURNAL.PBIO.3002387 | 2023-11-08 | |
| 8GHV | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4208628
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-023-37864-4 | 2023-05-24 | |
| 8J23 | FFAR2 | FFA2 | Free fatty acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 2024-04-17 | ||
| 6LRY | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
sarafotoxin S6b
pubchem
gtoplig
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 3.0 | Inactive | 10.1016/J.BBRC.2019.12.091 | 2020-02-12 | |
| 6VN7 | VIPR1 | VPAC1 | VIP and PACAP | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[Ac-His<sup>1</sup>]...
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41467-020-17933-8 | 2020-09-02 | |
| 2R4R | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | vapour diffusion | hanging drop | 5 chems | 6.5-7.5 | 22°C |
Carazolol
pubchem
|
Inverse agonist | 3.4 | Inactive | 2007-11-06 | |||
| 6OYA | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (all-trans)
pubchem
|
Agonist | 3.3 | Active | 10.1016/J.MOLCEL.2019.06.007 | 2019-07-24 | |
| 8GE8 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 8DZQ | OPRK | κ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SALVINORIN B METHOXY...
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41586-023-06030-7 | 2023-05-03 | |
| 8IEQ | GP156 | GPR156 | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2R)-3-[(E)-hexadec...
pubchem
|
Agonist | 2.7 | Inactive | 2024-02-14 | ||
| 6J20 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
aprepitant
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 2.7 | Inactive | 10.1038/S41467-019-08568-5 | 2019-03-06 | |
| 8XQO | T2R14 | TAS2R14 | Taste 2 | T2 (Taste 2) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
aristolochic acid
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.8 | Active | 10.1038/S41586-024-07569-9 | 2024-07-10 | |
| 8X16 | AA3R | A3 | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
piclidenoson
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.3 | Active | 10.1038/S41467-024-47207-6 | 2024-04-24 | |
| 7T9N | TSHR | TSH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
M22 antibody heavy c...
M22 antibody light c... |
AgonistAgonist | 2.9 | Active | 10.1038/S41586-022-05159-1 | 2022-08-03 | |
| 5JQH | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | 7.7 MAG | 5 chems | 7.5-7.5 | 23°C |
Carazolol
pubchem
|
Inverse agonist | 3.2 | Inactive | 10.1038/NATURE18636 | 2016-07-13 | |
| 8CU7 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LJ-4517
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.1 | Inactive | 10.1021/acs.jmedchem.2c00462 | 2022-08-31 | |
| 8JHY | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 9n [PMID: 1...
pubchem
gtoplig
chembl_ligand
|
PAM | 2.9 | Active | 10.1016/J.MOLCEL.2023.07.030 | 2023-09-06 | |
| 4OR2 | GRM1 | mGlu1 | Metabotropic glutamate | C (Glutamate) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C |
FITM
pubchem
gtoplig
chembl_ligand
|
NAM | 2.8 | Inactive | 10.1126/science.1249489 | 2014-03-19 | |
| 8GGB | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 9ASB | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cyclomethyltryptopha...
pubchem
tecalcet pubchem gtoplig chembl_ligand |
AgonistPAM | 3.4 | Active | 2024-04-17 | ||
| 6LFL | CXCR2 | CXCR2 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
4-[[3,4-Dioxo-2-[[(1...
pubchem
|
Allosteric antagonist | 3.2 | Inactive | 10.1038/S41586-020-2492-5 | 2020-09-02 | |
| 8JPN | SUCR1 | succinate | Succinate | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
<i>cis</i>-epoxysucc...
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.9 | Active | 2024-05-22 | ||
| 6ME5 | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
agomelatine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.2 | Inactive | 10.1038/S41586-019-1141-3 | 2019-04-24 | |
| 7VV4 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cortistatin 14
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41586-021-04077-Y | 2021-12-01 | |
| 7F8X | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
NN9056
|
Agonist | 3.0 | Inactive | 10.1038/S41589-021-00866-8 | 2021-12-29 | |
| 8UNQ | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 6OMM | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL552527
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41467-020-14728-9 | 2020-02-26 | |
| 9IIX | T2R14 | TAS2R14 | Taste 2 | T2 (Taste 2) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 28.1 [PMID:...
pubchem
gtoplig
chembl_ligand
compound 28.1 [PMID:... pubchem gtoplig chembl_ligand |
Allosteric agonistAgonist | 2.9 | Active | 2024-07-24 | ||
| 6XBK | SMO | SMO | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cholesterol
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41589-020-0646-2 | 2020-09-30 | |
| 8GE9 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 4NTJ | P2Y12 | P2Y12 | P2Y | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.5 | 20°C |
AZD1283
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.6 | Active | 10.1038/NATURE13083 | 2014-03-26 | |
| 7XP6 | T2R46 | TAS2R46 | Taste 2 | T2 (Taste 2) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
strychnine
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
gtoplig
|
Agonist | 3.0 | Active | 10.1126/SCIENCE.ABO1633 | 2022-10-12 | |
| 7SF8 | AGRG1 | ADGRG1 | ADGRG | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.7 | Active | 10.1038/S41586-022-04575-7 | 2022-04-27 | |
| 6PT2 | OPRD | δ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
KGCHM07
|
Agonist | 2.8 | Active | 10.1126/SCIADV.AAX9115 | 2019-12-11 | |
| 7E6T | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cyclomethyltryptopha...
pubchem
Calcium pubchem |
PAMAgonist | 3.0 | Active | 10.7554/ELIFE.68578 | 2021-09-22 | |
| 9JR3 | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Parathyroid hormone
pubchem
|
Agonist | 2.8 | Active | 2024-10-16 | ||
| 6BQH | 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
ritanserin
pubchem
gtoplig
chembl_ligand
drugbank
|
Inverse agonist | 2.7 | Inactive | 10.1016/j.cell.2018.01.001 | 2018-02-14 | |
| 7EW2 | S1PR3 | S1P3 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(S)-FTY720-phosphate
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.1 | Active | 10.1038/S41422-021-00567-W | 2021-09-29 | |
| 8K8J | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
FENOFIBRATE
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 10.1002/ADVS.202306311 | 2024-02-14 | |
| 8GE6 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |
| 7EWP | GP158 | GPR158 | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 4.3 | Inactive | 10.1038/S41467-021-27147-1 | 2021-12-01 | |
| 2YCZ | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | NA | 3 chems | 6.9-7.3 | NA |
Iodocyanopindolol
pubchem
|
Antagonist | 3.7 | Inactive | 10.1073/PNAS.1100185108 | 2011-06-01 | ||
| 7XRR | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lemborexant
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Antagonist | 2.9 | Inactive | 10.1016/J.STR.2022.11.001 | 2022-11-23 | |
| 7FIG | LSHR | LH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Glycoprotein alpha
gtoplig
Choriogonadotropin b... gtoplig |
AgonistAgonist | 3.9 | Active | 10.1038/S41586-021-03924-2 | 2021-09-29 | |
| 8XQT | T2R14 | TAS2R14 | Taste 2 | T2 (Taste 2) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cholesterol
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41586-024-07569-9 | 2024-07-10 | |
| 6M1H | PACR | PAC1 | VIP and PACAP | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
maxadilan
gtoplig
pubchem
|
Agonist | 3.6 | Active | 10.1038/S41422-020-0280-2 | 2020-03-11 | |
| 7W0P | APJ | apelin | Apelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apelin receptor earl...
|
Agonist | 3.2 | Active | 10.1038/S41594-022-00797-5 | 2022-07-27 | |
| 2X72 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Stable_cells | HEK293S-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 3 chems | 4.5-4.5 | 4°C |
Retinal (all-trans)
pubchem
|
Agonist | 3.0 | Active | 10.1038/NATURE09795 | 2011-03-16 | ||
| 8IRV | DRD5 | D5 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
rotigotine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41422-023-00808-0 | 2023-06-07 | |
| 8FLQ | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Parathyroid hormone
|
Agonist | 2.6 | Active | 10.1016/J.STR.2023.04.002 | 2023-04-26 | |
| 8U8F | GPR3 | GPR3 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
palmitic acid
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
|
Agonist | 3.5 | Active | 10.1021/ACS.BIOCHEM.3C00647 | 2024-03-06 | |
| 8RQQ | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.4 | Inactive | 2024-04-03 | ||
| 8ZMG | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
pimavanserin
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Inverse agonist | 3.4 | Inactive | 2024-08-28 | ||
| 6N4B | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MDMB-Fubinaca
pubchem
gtoplig
|
Agonist | 3.0 | Active | 10.1016/J.CELL.2018.11.040 | 2019-01-30 | |
| 7WIG | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
~{N}-[(2~{R})-1-[[(1...
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41422-022-00669-Z | 2022-06-01 | |
| 7EXD | 5HT1F | 5-HT1F | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lasmiditan
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41422-021-00527-4 | 2021-08-04 | |
| 8WWJ | MCHR1 | MCH1 | Melanin-concentrating hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.0 | Active | 2024-11-13 | ||
| 8JII | HCAR2 | HCA2 | Hydroxycarboxylic acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
nicotinic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
compound 9n [PMID: 1... pubchem gtoplig chembl_ligand |
AgonistPAM | 3.2 | Active | 10.1016/J.MOLCEL.2023.07.030 | 2023-09-06 | |
| 6YVR | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JMV431
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.5 | Inactive | 10.1126/sciadv.abe5504 | 2021-02-10 | |
| 4X1H | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 3 chems | 5.0-6.5 | 4°C |
B-Nonylglucoside
pubchem
|
unknown | 2.3 | Active | 10.1016/J.STR.2015.09.015 | 2015-11-04 | ||
| 5XJM | AGTR2 | AT2 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL404594
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41594-018-0079-8 | 2018-07-11 | |
| 4U15 | ACM3 | M3 | Acetylcholine (muscarinic) | A (Rhodopsin) | Rat | Baculovirus | Sf9 | Insect | 9 chemicals | 9 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.5-7.5 | 298 K |
tiotropium
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
chembl_ligand
chembl_ligand
pubchem
|
Antagonist | 2.8 | Inactive | 10.1016/J.STR.2014.08.022 | 2014-11-26 | |
| 8XGS | KISSR | kisspeptin | Kisspeptin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Kisspeptin-10
pubchem
|
Agonist | 3.0 | Active | 10.1126/SCIADV.ADN7771 | 2024-10-30 | |
| 8GGN | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(5R,6R)-6-(methylami...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-024-07153-1 | 2024-03-06 | |