Experiment Browser
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| RECEPTOR | EXPRESSION | SOLUBILIZATION | PURIFICATION | STRUCTURE DETERMINATION | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | pH | Temp | Resolution | Reference | Date | ||||||||||||||||||
| 3EML | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.5-6.5 | 20°C |
ZM241385
pubchem
|
Antagonist | 2.6 | Inactive | 10.1126/SCIENCE.1164772 | 2008-10-14 | |
| 4XEE | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-8.0 | 20°C |
CHEMBL342252
pubchem
|
Agonist | 2.9 | Intermediate | 10.1038/NCOMMS8895 | 2015-07-29 | |
| 4RWA | OPRD | δ | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.0-6.0 | 20°C |
DIPP-NH2
|
Antagonist | 3.3 | Inactive | 10.1038/NSMB.2965 | 2015-01-14 | |
| 2I37 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 2 chemicals | 2 steps | vapour diffusion | sitting drops | 5 chems | 7.0-8.0 | 5°C | N/A | N/A | 4.2 | Inactive | 10.1073/PNAS.0608022103 | 2006-10-17 | ||
| 6FK6 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
(2~{S})-2-(4-chlorop...
|
Agonist | 2.4 | Active | 2018-04-04 | |||
| 5W0P | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Human | Transient_transfection | HEK293S(TetR- GnTI- | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monopalmitolein (9.7 MAG) | 5 chems | 5.0-5.0 | 20°C | N/A | N/A | 3.0 | Active | 10.1016/J.CELL.2017.07.002 | 2017-08-09 | |
| 4AMI | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | sitting drops | 3 chems | 9.0-9.0 | 4°C |
bucindolol
pubchem
|
Agonist | 3.2 | Inactive | 10.1016/J.STR.2012.03.014 | 2012-05-23 | ||
| 5WKT | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drop | 4 chems | 5.5-5.5 | 7-10°C | N/A | N/A | 3.2 | Active | 10.1038/NPROT.2017.135 | 2017-12-13 | ||
| 3UON | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.5-7.5 | 19.85°C |
62869-69-6
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/NATURE10753 | 2012-02-01 | |
| 5ZK8 | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-methyl scopolamine
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/S41589-018-0152-Y | 2018-11-21 | |
| 1U19 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 6.5-7.5 | 283 K |
retinal
gtoplig
|
Inverse agonist | 2.2 | Inactive | 10.1016/J.JMB.2004.07.044 | 2004-10-12 | ||
| 6FK9 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
(2~{S})-3-methyl-2-p...
|
Agonist | 2.6 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
| 5EE7 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | Transient_transfection | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-6.5 | 20°C |
3,6,9,12,15,18,21,24...
pubchem
|
Antagonist | 2.5 | Inactive | 10.1038/NATURE17414 | 2016-04-20 | |
| 6NIY | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PEP
|
Agonist | 3.3 | Active | 2019-01-23 | ||
| 3NY9 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.5-8.0 | 20°C |
CHEMBL1233771
pubchem
|
Inverse agonist | 2.8 | Inactive | 10.1021/JA105108Q | 2010-08-11 | |
| 6FK8 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
(2~{R},3~{S})-3-azan...
|
Agonist | 2.9 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
| 5YHL | PE2R4 | EP4 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ONO-AE3-208-Br
|
Antagonist | 4.2 | Inactive | 10.1038/S41589-018-0131-3 | 2018-12-05 | |
| 4UHR | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 4.8-4.8 | 22°C |
Cgs 21680
pubchem
|
Agonist | 2.6 | Intermediate | 10.1124/MOL.114.097360 | 2015-04-08 | |
| 5VAI | G1SGD4 | GLP-1 | Glucagon | B1 (Secretin) | Rabbit | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | Cryo-EM | FEI, glow-discharged holey carbon grids | 7 chems | 7.5-7.5 | 20°C |
GLP-1
pubchem
|
Agonist | 4.1 | Active | 10.1038/NATURE22394 | 2017-05-24 | ||
| 4IB4 | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 8.0-8.5 | 20°C |
ERGOTAMINE
pubchem
|
Agonist | 2.7 | Intermediate | 10.1126/SCIENCE.1232808 | 2013-03-13 | |
| 5ZKP | PTAFR | PAF | Platelet-activating factor | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Foropafant
pubchem
|
Antagonist | 2.8 | Active | 10.1038/S41594-018-0068-Y | 2018-06-20 | |
| 5DHH | OPRX | NOP | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.4-6.4 | 20°C | N/A | N/A | 3.0 | Inactive | 10.1016/J.STR.2015.07.024 | 2015-10-21 | |
| 5N2R | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20 |
PSB36
pubchem
|
Antagonist | 2.8 | Inactive | 10.1016/J.STR.2017.06.012 | 2017-07-26 | |
| 2YCY | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | NA | 3 chems | 6.9-7.3 | NA |
(S)-Cyanopindolol
pubchem
|
Antagonist | 3.2 | Inactive | 10.1073/PNAS.1100185108 | 2011-06-08 | ||
| 5TZR | FFAR1 | FFA1 | Free fatty acid | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.7-8.3 | 20°C |
UNII-11612L5SPI
pubchem
|
Agonist | 2.2 | Intermediate | 10.1038/NSMB.3417 | 2017-06-07 | |
| 4O9R | SMO | SMO | Frizzled | F (Frizzled) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 7.4-7.4 | 20°C |
Cyclopamine
pubchem
|
Antagonist | 3.2 | Inactive | 10.1038/NCOMMS4309 | 2014-03-05 | |
| 3C9L | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | NA | NA | 1 chemicals | 1 steps | NA | NA | NA | 1 chems | 0.0-0.0 | NA |
retinal
gtoplig
|
Inverse agonist | 2.7 | Inactive | 10.1107/S0907444908017162 | 2008-08-05 | |
| 6E3Y | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcitonin gene-rela...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-018-0535-Y | 2018-09-19 | |
| 3OE0 | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
CVX15
|
Antagonist | 2.9 | Inactive | 10.1126/SCIENCE.1194396 | 2010-10-27 | |
| 6FFI | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-6.8 | 20°C |
2-[2-(3-methoxypheny...
pubchem
|
NAM | 2.2 | Inactive | 10.1021/ACS.JMEDCHEM.7B01722 | 2018-03-07 | |
| 3REY | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | vapour diffusion | Sitting drop | 6 chems | 8.0-8.8 | 4°C |
Xanthine amine conge...
pubchem
|
Antagonist | 3.3 | Inactive | 10.1016/J.STR.2011.06.014 | 2011-09-07 | ||
| 4XT1 | US28 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 6.3-7.0 | 20°C |
CX3CL1
|
Agonist | 2.9 | Active | 10.1126/SCIENCE.AAA5026 | 2015-03-04 | |
| 6BD4 | FZD4 | FZD4 | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 2.4 | Inactive | 10.1038/S41586-018-0447-X | 2018-08-22 | |
| 6G79 | 5HT1B | 5-HT1B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | Cryo-EM | Volta phase plate, Falcon III detector (FEI Titan Krios, 300kV) | 5 chems | 7.5-7.5 | 4°C |
Donitriptan
pubchem
|
Agonist | 3.8 | Active | 10.1038/S41586-018-0241-9 | 2018-06-20 | ||
| 4XT3 | US28 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monovaccenin(11.7 MAG) | 6 chems | 7.4-7.4 | 20°C |
Fractalkine
|
Agonist | 3.8 | Active | 10.1126/SCIENCE.AAA5026 | 2015-03-04 | |
| 5NM4 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM 241385
pubchem
|
Antagonist | 1.7 | Inactive | 10.1038/S41467-017-00630-4 | 2017-09-27 | |
| 4XNW | P2RY1 | P2Y1 | P2Y | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-8.0 | 20°C |
MRS2500
pubchem
|
Antagonist | 2.7 | Intermediate | 10.1038/NATURE14287 | 2015-04-01 | |
| 6J20 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Aprepitant
pubchem
chembl_ligand
|
Antagonist | 2.7 | Inactive | 10.1038/S41467-019-08568-5 | 2019-03-06 | |
| 5ZKC | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-methyl scopolamine
pubchem
|
Antagonist | 2.3 | Inactive | 10.1038/S41589-018-0152-Y | 2018-11-21 | |
| 5WF6 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-5.0 | 20°C |
UK-432,097
pubchem
|
Agonist | 2.9 | Intermediate | 10.1016/J.STR.2017.12.013 | 2018-02-21 | |
| 2Y03 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 6 chems | 8.5-8.5 | 4°C |
LEVISOPRENALINE
pubchem
|
Agonist | 2.9 | Inactive | 10.1038/NATURE09746 | 2011-01-12 | ||
| 4AMJ | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | sitting drops | 3 chems | 9.0-9.0 | 4°C |
(S)-Carvedilol
pubchem
|
Inverse agonist | 2.3 | Inactive | 10.1016/J.STR.2012.03.014 | 2012-05-23 | ||
| 5VBL | APJ | apelin | Apelin | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 6.1-6.1 | 20-22°C |
AMG3054
|
Agonist | 2.6 | Inactive | 10.1016/J.STR.2017.04.008 | 2017-05-31 | |
| 5CGD | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-6.8 | 20°C |
CHEMBL3603923
pubchem
|
NAM | 2.6 | Inactive | 10.1021/ACS.JMEDCHEM.5B00892 | 2015-08-12 | |
| 6C1R | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.5-6.5 | 10°C |
PMX53
pubchem
chembl_ligand
Avacopan pubchem |
AntagonistAntagonist | 2.2 | Inactive | 10.1038/S41594-018-0067-Z | 2018-05-30 | |
| 5OLG | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
ZM241385
pubchem
|
Antagonist | 1.9 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
| 5UEN | AA1R | A1 | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-8.0 | 20°C |
CHEMBL144360
pubchem
|
Antagonist | 3.2 | Inactive | 10.1016/J.CELL.2017.01.042 | 2017-03-01 | |
| 5ZBH | NPY1R | Y1 | Neuropeptide Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
BMS-193885
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/S41586-018-0046-X | 2018-04-25 | |
| 5T1A | CCR2 | CCR2 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 6.5-6.5 | 20 °C. |
CCR2-RA-[R]
pubchem
CHEMBL3577945 pubchem |
AntagonistAntagonist | 2.8 | Inactive | 10.1038/NATURE20605 | 2016-12-14 | |
| 5X33 | Q9WTK1 | BLT1 | Leukotriene | A (Rhodopsin) | Guinea pig | Pichia Pastoris | P. pastoris SMD1163 | Yeast | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 8.5-9.0 | 4°C |
BIIL-260
pubchem
|
Antagonist | 3.7 | Inactive | 10.1038/NCHEMBIO.2547 | 2018-01-03 | |
| 6AKY | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
4,4-difluoro-N-[(1S)...
|
Antagonist | 2.8 | Inactive | 10.1021/ACS.JMEDCHEM.8B01077 | 2018-10-24 | |
| 1HZX | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 2 chemicals | 2 steps | vapour diffusion | Hanging drops | 7 chems | 6.0-6.0 | 4°C |
retinal
gtoplig
|
Inverse agonist | 2.8 | Inactive | 10.1021/BI0155091 | 2001-07-04 | ||
| 3PDS | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 3 chemicals | 3 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.7-6.7 | 20°C |
FAUC50
pubchem
|
Agonist | 3.5 | Inactive | 10.1038/NATURE09665 | 2011-01-12 | |
| 2YDV | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 4 chemicals | 4 steps | vapour diffusion | sitting drop | 5 chems | 6.4-6.4 | 4°C |
NECA
pubchem
|
Agonist | 2.6 | Intermediate | 10.1038/NATURE10136 | 2011-05-18 | ||
| 5OLH | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
Vipadenant
|
Antagonist | 2.6 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
| 3ZEV | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | NA | E. coli BL21(DE3) | Bacteria | 3 chemicals | 3 steps | vapour diffusion | sitting drops | 7 chems | 9.4-9.4 | 4°C |
CHEMBL342252
pubchem
|
Agonist | 3.0 | Inactive | 10.1073/PNAS.1317903111 | 2014-01-29 | ||
| 5OLO | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
Tozadenant
pubchem
chembl_ligand
|
Antagonist | 3.1 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
| 5UNH | AGTR2 | AT2 | Angiotensin | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 8.0-8.0 | 20°C |
8EM
pubchem
|
Antagonist | 2.9 | Active | 10.1038/NATURE22035 | 2017-04-05 | |
| 5UZ7 | CALCR | CT | Calcitonin | B1 (Secretin) | Human | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | Cryo-EM | Volta phase plate (FEI) | 6 chems | 7.4-7.4 | cryoTemp(liquid Nitrogen) | N/A | N/A | 4.1 | Active | 10.1038/NATURE22327 | 2017-05-03 | ||
| 4ZJC | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.6-5.6 | 20°C |
SB-674042
pubchem
|
Antagonist | 2.8 | Inactive | 10.1038/NSMB.3183 | 2016-03-09 | |
| 4XES | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.4 | 20°C |
CHEMBL342252
pubchem
|
Agonist | 2.6 | Intermediate | 10.1038/NCOMMS8895 | 2015-07-29 | |
| 6N4B | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Fub-mdmb
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.CELL.2018.11.040 | 2019-01-30 | |
| 6D27 | PD2R2 | DP2 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CAY10471
pubchem
chembl_ligand
|
Antagonist | 2.7 | Inactive | 2018-10-03 | ||
| 4N6H | OPRD | δ | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 6.1-6.2 | 20-23°C |
Naltrindole
pubchem
|
Antagonist | 1.8 | Inactive | 10.1038/NATURE12944 | 2013-12-25 | |
| 4RWS | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20°C |
vMIP-II
|
Antagonist | 3.1 | Inactive | 10.1126/SCIENCE.1261064 | 2015-02-11 | |
| 5F8U | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 1 chems | 3.6-4.0 | 18°C |
(S)-Cyanopindolol
pubchem
|
Antagonist | 3.4 | Inactive | 10.1038/NSMB.3130 | 2015-12-23 | ||
| 5D5B | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.5-7.0 | 20°C |
Carazolol
pubchem
|
Inverse agonist | 3.8 | Inactive | 10.1107/S2059798315021683 | 2016-01-13 | |
| 6MEO | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Envelope glycoprotei...
|
Antagonist | 3.9 | Inactive | 10.1038/S41586-018-0804-9 | 2018-12-12 | |
| 5TVN | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.5-8.0 | 20°C |
Lysergide
pubchem
|
Agonist | 2.9 | Intermediate | 10.1016/J.CELL.2016.12.033 | 2017-02-01 | |
| 6FKB | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
2-(4-chlorophenyl)-1...
|
Agonist | 3.0 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
| 5ZTY | CNR2 | CB2 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AM10257
pubchem
|
Antagonist | 2.8 | Inactive | 10.1016/J.CELL.2018.12.011 | 2019-01-30 | |
| 4NTJ | P2Y12 | P2Y12 | P2Y | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.5 | 20°C |
AZD1283
pubchem
|
Antagonist | 2.6 | Intermediate | 10.1038/NATURE13083 | 2014-03-26 | |
| 5IU4 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20 |
ZM241385
pubchem
|
Antagonist | 1.7 | Inactive | 10.1021/ACS.JMEDCHEM.6B00653 | 2016-06-29 | |
| 5OM1 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
4-(3-amino-5-phenyl-...
|
Antagonist | 2.1 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
| 2Y00 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 6 chems | 8.5-8.5 | 4°C |
Dobutamine
pubchem
|
Agonist (partial) | 2.5 | Inactive | 10.1038/NATURE09746 | 2011-01-12 | ||
| 6IGK | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Endothelin-3
pubchem
|
Agonist | 2.0 | Intermediate | 10.1038/S41467-018-07094-0 | 2018-11-21 | |
| 3V2W | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.8-7.8 | 20°C |
W146
pubchem
|
Antagonist | 3.4 | Inactive | 10.1126/SCIENCE.1215904 | 2012-02-15 | |
| 6H7O | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
4-{[(2S)-3-(tert-but...
pubchem
|
Agonist | 2.8 | Active | 10.1101/436212 | 2018-10-17 | |
| 5OLV | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
CHEMBL1671936
pubchem
chembl_ligand
|
Antagonist | 2.0 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
| 5L7D | SMO | SMO | Frizzled | F (Frizzled) | Human | Transient_transfection | HEK293S(TetR)-GnTI- | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 4.0-4.0 | 20°C | N/A | N/A | 3.2 | Inactive | 10.1038/NATURE18934 | 2016-07-20 | |
| 3QAK | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.5 | 20°C |
UK-432097
pubchem
|
Agonist | 2.7 | Intermediate | 10.1126/SCIENCE.1202793 | 2011-03-09 | |
| 4PHU | FFAR1 | FFA1 | Free fatty acid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.6-7.6 | 20°C |
TAK-875
pubchem
|
Agonist | 2.3 | Intermediate | 10.1038/NATURE13494 | 2014-07-16 | |
| 6IIU | TA2R | TP | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Ramatroban
pubchem
chembl_ligand
|
Antagonist | 2.5 | Inactive | 10.1038/S41589-018-0170-9 | 2018-12-19 | |
| 5TE5 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drop | 4 chems | 5.2-6.6 | 4°C |
10,20-Methanoretinal
pubchem
|
Agonist | 4.0 | Inactive | 10.1073/PNAS.1617446114 | 2017-03-15 | ||
| 5XEZ | GLR | glucagon | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C |
4-{[(4-Cyclohexylphe...
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/NATURE22363 | 2017-05-24 | |
| 5DYS | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Stable_cells | HEK293S-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Sitting drop | 4 chems | 4.5-4.5 | 20°C |
retinal
gtoplig
|
Inverse agonist | 2.3 | Active | 10.15252/EMBR.201642671 | 2016-08-10 | ||
| 3OE9 | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.0-6.0 | 20°C |
IT1t
pubchem
|
Antagonist | 3.1 | Inactive | 10.1126/SCIENCE.1194396 | 2010-10-27 | |
| 3PQR | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 3 chems | 5.6-5.6 | 4°C |
retinal
gtoplig
|
Agonist | 2.9 | Active | 10.1038/NATURE09789 | 2011-03-09 | ||
| 3RZE | HRH1 | H1 | Histamine | A (Rhodopsin) | Human | Pichia Pastoris | P. pastoris SMD1163 | Yeast | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 4.5-4.5 | 20-22°C |
doxepin
pubchem
|
Antagonist | 3.1 | Inactive | 10.1038/NATURE10236 | 2011-06-15 | |
| 5MZP | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20 |
Caffeine
pubchem
|
Antagonist | 2.1 | Inactive | 10.1016/J.STR.2017.06.012 | 2017-07-26 | |
| 5UNG | AGTR2 | AT2 | Angiotensin | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 8.0-8.0 | 20°C |
CHEMBL289472
pubchem
|
Antagonist | 2.8 | Active | 10.1038/NATURE22035 | 2017-04-05 | |
| 3OAX | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 6.0-6.0 | 283 K |
retinal
gtoplig
|
Inverse agonist | 2.6 | Inactive | 10.1016/J.BPJ.2010.08.003 | 2011-01-19 | ||
| 5UIW | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.3-6.3 | 20°C |
5P7-CCL5
|
Antagonist | 2.2 | Inactive | 10.1016/J.IMMUNI.2017.05.002 | 2017-06-28 | |
| 5WS3 | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 9 chemicals | 9 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.8-6.2 | 20°C |
EMPA
pubchem
chembl_ligand
|
Antagonist | 2.3 | Inactive | 10.1016/J.STR.2017.11.005 | 2017-12-13 | |
| 4BVN | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | Baculovirus | Hi5 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 7.0-7.0 | 22°C |
(S)-Cyanopindolol
pubchem
|
Antagonist | 2.1 | Inactive | 10.1371/JOURNAL.PONE.0092727 | 2014-04-02 | |
| 2YCW | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | NA | 3 chems | 8.1-8.1 | NA |
timolol
pubchem
|
Inverse agonist | 3.0 | Inactive | 10.1073/PNAS.1100185108 | 2011-06-01 | ||
| 4U14 | ACM3 | M3 | Acetylcholine (muscarinic) | A (Rhodopsin) | Rat | Baculovirus | Sf9 | Insect | 9 chemicals | 9 steps | sponge mesophase | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 8.1-8.1 | 298 K |
Tiotropium
pubchem
|
Antagonist | 3.6 | Inactive | 10.1016/J.STR.2014.08.022 | 2014-11-26 | |
| 4QKX | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | 7.7 MAG | 5 chems | 7.8-8.4 | 20°C |
35V
pubchem
|
Agonist | 3.3 | Active | 10.1073/PNAS.1410415111 | 2014-07-23 | |
| 5IU7 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
2-(Furan-2-Yl)-N~5~-...
pubchem
|
Agonist | 1.9 | Inactive | 10.1021/ACS.JMEDCHEM.6B00653 | 2016-06-29 | |
| 5XJM | AGTR2 | AT2 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(Sar1,Ile8)-angionte...
pubchem
chembl_ligand
|
Agonist | 3.2 | Active | 10.1038/S41594-018-0079-8 | 2018-07-11 | |
| 4Z36 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.5-5.5 | 20°C |
ONO-3080573
pubchem
|
Antagonist | 2.9 | Inactive | 10.1016/J.CELL.2015.06.002 | 2015-06-03 | |
| 5A8E | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 7.0-7.0 | 20°C |
7-methylcyanopindolo...
|
Inverse agonist | 2.4 | Inactive | 10.1124/MOL.115.101030 | 2015-09-30 | |
| 5V54 | 5HT1B | 5-HT1B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 7.0-7.0 | 20°C |
CHEMBL428892
pubchem
chembl_ligand
|
Antagonist | 3.9 | Intermediate | 2018-02-07 | ||
| 1F88 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 2 chemicals | 2 steps | vapour diffusion | Hanging drop | 7 chems | 6.0-6.0 | 4°C |
retinal
gtoplig
|
Inverse agonist | 2.8 | Inactive | 10.1126/SCIENCE.289.5480.739 | 2000-08-04 | ||
| 3AYM | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Japanese flying squid | NA | Native | Squid | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 5 chems | 6.6-6.6 | 4°C |
retinal
gtoplig
|
Agonist | 2.8 | Inactive | 10.1016/J.JMB.2011.08.044 | 2011-08-17 | ||
| 4IAQ | 5HT1B | 5-HT1B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 8.7-8.7 | 20°C |
dihydroergotamine
pubchem
|
Agonist | 2.8 | Intermediate | 10.1126/SCIENCE.1232807 | 2013-03-13 | |
| 5D6L | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C |
Carazolol
pubchem
|
Inverse agonist | 3.2 | Inactive | 10.1038/NPROT.2017.057 | 2016-08-17 | |
| 5JTB | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM241385
pubchem
|
Antagonist | 2.8 | Inactive | 10.1126/SCIADV.1602952 | 2017-05-31 | |
| 5TUD | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monopalmitolein (9.7 MAG) | 6 chems | 7.7-7.7 | 20°C |
Ergotamine
pubchem
|
Agonist | 3.0 | Active | 10.1073/PNAS.1700891114 | 2017-07-26 | |
| 6DRZ | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Methysergide
pubchem
|
Antagonist | 3.1 | Intermediate | 10.1038/S41594-018-0116-7 | 2018-08-29 | |
| 5V56 | SMO | SMO | Frizzled | F (Frizzled) | Human | Transient_transfection | HEK293F | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
N-methyl-N-[1-[4-(2-...
pubchem
|
Antagonist | 2.9 | Inactive | 10.1038/NCOMMS15383 | 2017-05-24 | |
| 6B3J | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 2 chemicals | 2 steps | Cryo-EM | Volta phase plate (FEI) | 5 chems | 7.4-7.4 | 4°C |
Exendin-P5
|
Agonist | 3.3 | Active | 10.1038/NATURE25773 | 2018-02-21 | ||
| 3OE8 | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.0-6.0 | 20°C |
IT1t
pubchem
|
Antagonist | 3.1 | Inactive | 10.1126/SCIENCE.1194396 | 2010-10-27 | |
| 4EJ4 | OPRD | δ | Opioid | A (Rhodopsin) | Mouse | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.5-7.5 | 20°C |
Naltrindole
pubchem
|
Antagonist | 3.4 | Inactive | 10.1038/NATURE11111 | 2012-05-16 | |
| 2Y01 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 6 chems | 9.0-9.0 | 4°C |
Dobutamine
pubchem
|
Agonist (partial) | 2.6 | Inactive | 10.1038/NATURE09746 | 2011-03-30 | ||
| 6MET | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Envelope glycoprotei...
|
Antagonist | 4.5 | Inactive | 10.1038/S41586-018-0804-9 | 2018-12-12 | |
| 4BWB | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | NA | E. coli BL21(DE3) | Bacteria | 3 chemicals | 3 steps | vapour diffusion | sitting drops | 7 chems | 5.5-5.5 | 4°C |
CHEMBL342252
pubchem
|
Agonist | 3.6 | Inactive | 10.1073/PNAS.1317903111 | 2014-01-29 | ||
| 6H7M | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SALBUTAMOL
pubchem
|
Agonist | 2.8 | Active | 10.1101/436212 | 2018-10-17 | |
| 6MXT | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Salmeterol
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41589-018-0145-X | 2018-11-14 | |
| 2ZIY | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Japanese flying squid | NA | Native | Squid | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 7.0-7.0 | 20°C |
retinal
gtoplig
|
Inverse agonist | 3.7 | Inactive | 10.1074/JBC.C800040200 | 2008-05-06 | ||
| 5NX2 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | vapour diffusion | Sitting drop | 4 chems | 8.0-9.0 | 10°C |
truncated protein ag...
|
Agonist | 3.7 | Intermediate | 10.1038/NATURE22800 | 2017-06-14 | ||
| 6DRX | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Lisuride
pubchem
|
Antagonist | 3.1 | Intermediate | 10.1038/S41594-018-0116-7 | 2018-08-29 | |
| 6N52 | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 4.0 | Inactive | 10.1038/S41586-019-0881-4 | 2019-01-23 | |
| 4IAR | 5HT1B | 5-HT1B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.5-7.5 | 20°C |
ERGOTAMINE
pubchem
|
Agonist | 2.7 | Intermediate | 10.1126/SCIENCE.1232807 | 2013-03-13 | |
| 3SN6 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | sponge mesophase | lipidic cubic phase (LCP) | 7.7 MAG | 6 chems | 6.5-6.5 | 20°C |
BI-167107
pubchem
|
Agonist | 3.2 | Active | 10.1038/NATURE10361 | 2011-07-20 | |
| 4RWD | OPRD | δ | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
DIPP-NH2
|
Antagonist | 2.7 | Inactive | 10.1038/NSMB.2965 | 2015-01-14 | |
| 6A93 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Risperidone
pubchem
chembl_ligand
|
Antagonist | 3.0 | Inactive | 10.1038/S41594-018-0180-Z | 2019-02-13 | |
| 3ZPQ | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 3 chems | 9.0-9.0 | 4°C |
4-(1-Piperazinyl)-1H...
pubchem
|
Antagonist | 2.8 | Inactive | 10.1021/JM400140Q | 2013-04-03 | ||
| 5WIV | DRD4 | D4 | Dopamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.9-6.2 | 20°C |
Nemonapride
pubchem
|
Antagonist | 2.1 | Inactive | 10.1126/SCIENCE.AAN5468 | 2017-10-18 | |
| 1L9H | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 6.0-6.0 | 4°C |
retinal
gtoplig
|
Inverse agonist | 2.6 | Inactive | 10.1073/PNAS.082666399 | 2002-05-15 | ||
| 6DDF | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | Cryo-EM | Gatan K2 Summit direct electron camera , 300kV | 5 chems | 7.5-7.5 | 4°C |
DAMGO
pubchem
chembl_ligand
|
Agonist | 3.5 | Active | 10.1038/S41586-018-0219-7 | 2018-06-13 | ||
| 6FKC | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
3-[1'-[(2~{S})-2-(4-...
|
Agonist | 2.5 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
| 6CM4 | DRD2 | D2 | Dopamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 6 chems | 7.8-7.8 | 20°C |
Risperidone
pubchem
chembl_ligand
|
Inverse agonist | 2.9 | Inactive | 10.1038/NATURE25758 | 2018-03-14 | |
| 3VGA | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | P.pastoris | P. pastoris SMD1163 | Yeast | 2 chemicals | 2 steps | vapour diffusion | hanging drop | 4 chems | 6.5-6.5 | 20°C |
ZM241385
pubchem
|
Antagonist | 3.1 | Inactive | 10.1038/NATURE10750 | 2012-02-01 | ||
| 4S0V | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 9 chemicals | 9 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.9-6.0 | 20°C |
Suvorexant
pubchem
|
Antagonist | 2.5 | Inactive | 10.1038/NATURE14035 | 2015-01-14 | |
| 1GZM | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 3 chems | 8.5-8.5 | 18°C |
retinal
gtoplig
|
Inverse agonist | 2.7 | Inactive | 10.1016/J.JMB.2004.08.090 | 2003-11-20 | ||
| 4ZJ8 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.4-5.4 | 20°C |
Suvorexant
pubchem
|
Antagonist | 2.8 | Inactive | 10.1038/NSMB.3183 | 2016-03-09 | |
| 5GLH | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | Baculovirus | SF+ | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.0-6.0 | 20°C |
Et 1
pubchem
|
Agonist | 2.8 | Inactive | 10.1038/NATURE19319 | 2016-09-07 | |
| 3KJ6 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 3 chemicals | 3 steps | vapour diffusion | bicelles | 5 chems | 7.5-7.5 | 298K | N/A | N/A | 3.4 | Inactive | 10.1038/NATURE08650 | 2010-02-16 | ||
| 2R4R | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | vapour diffusion | hanging drop | 5 chems | 6.5-7.5 | 22°C | N/A | N/A | 3.4 | Inactive | 10.1038/NATURE06325 | 2007-11-06 | ||
| 4PXZ | P2Y12 | P2Y12 | P2Y | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-6.0 | 20°C |
2-MeSADP
pubchem
|
Agonist | 2.5 | Intermediate | 10.1038/NATURE13288 | 2014-04-30 | |
| 6AKX | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-[(1S)-3-{(3-exo)-3...
|
Antagonist | 2.8 | Inactive | 10.1021/ACS.JMEDCHEM.8B01077 | 2018-10-24 | |
| 6IGL | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
IRL1620
pubchem
|
Partial agonist | 2.7 | Inactive | 10.1038/S41467-018-07094-0 | 2018-11-21 | |
| 4MBS | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C |
Maraviroc
pubchem
|
Antagonist | 2.7 | Inactive | 10.1126/SCIENCE.1241475 | 2013-09-11 | |
| 4L6R | GLR | glucagon | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C | N/A | N/A | 3.3 | Inactive | 10.1038/NATURE12393 | 2013-07-24 | |
| 6CMO | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | Cryo-EM | FEI TITAN Krios microscope,Gatan K2 Summit direct electron camera,GIF-quantum energy filter (Gatan) | 4 chems | 7.2-7.2 | 4°C | N/A | N/A | 4.5 | Active | 10.1038/S41586-018-0215-Y | 2018-06-20 | ||
| 3AYN | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Japanese flying squid | NA | Native | Squid | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 5 chems | 6.0-6.0 | 4°C |
retinal
gtoplig
|
Inverse agonist | 2.7 | Inactive | 10.1016/J.JMB.2011.08.044 | 2011-08-17 | ||
| 6J21 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Aprepitant
pubchem
chembl_ligand
|
Antagonist | 3.2 | Inactive | 10.1038/S41467-019-08568-5 | 2019-03-06 | |
| 4DJH | OPRK | κ | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
JDTic
pubchem
|
Antagonist | 2.9 | Inactive | 10.1038/NATURE10939 | 2012-03-21 | |
| 5C1M | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 7.5-7.5 | 20°C |
BU72
pubchem
|
Agonist | 2.1 | Active | 10.1038/NATURE14886 | 2015-08-05 | |
| 4N4W | SMO | SMO | Frizzled | F (Frizzled) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 6.9-6.9 | 20°C |
SANT-1
pubchem
|
Antagonist | 2.8 | Inactive | 10.1038/NCOMMS5355 | 2014-01-22 | |
| 6GDG | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | Cryo-EM | Falcon III detector , 300kV, FEI TITAN Krios microscope, Volta PhasePlate, GIF-quantum energy filter (Gatan) | 4 chems | 7.5-7.5 | 4°C |
NECA
pubchem
|
Agonist | 4.1 | Active | 10.7554/ELIFE.35946 | 2018-05-16 | ||
| 4YAY | AGTR1 | AT1 | Angiotensin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 6 chems | 5.0-6.0 | 20°C |
ZD7155
pubchem
|
Antagonist | 2.9 | Inactive | 10.1016/J.CELL.2015.04.011 | 2015-04-22 | |
| 5X7D | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 3 chemicals | 3 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 7.5-7.5 | 20°C |
Carazolol
pubchem
4-carbamoyl-N-[(2R)-... pubchem |
AntagonistAntagonist | 2.7 | Inactive | 10.1038/NATURE23652 | 2017-08-16 | |
| 5ZK3 | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Quinuclidinyl benzil...
pubchem
|
Antagonist | 2.6 | Inactive | 10.1038/S41589-018-0152-Y | 2018-11-21 | |
| 3P0G | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 8.0-8.0 | 20°C |
BI-167107
pubchem
|
Agonist | 3.5 | Active | 10.1038/NATURE09648 | 2011-01-19 | |
| 4WW3 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Japanese flying squid | NA | Native | Squid | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 4 chems | 6.4-6.4 | 100-170 K |
retinal
gtoplig
|
Inverse agonist | 2.8 | Inactive | 10.1371/JOURNAL.PONE.0126970 | 2015-06-17 | ||
| 4MQT | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.2-7.9 | 20°C |
LY2119620
pubchem
iperoxo pubchem |
PAMAgonist | 3.7 | Active | 10.1038/NATURE12735 | 2013-11-27 | |
| 3VG9 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | P.pastoris | P. pastoris SMD1163 | Yeast | 2 chemicals | 2 steps | vapour diffusion | hanging drop | 4 chems | 6.5-6.5 | 20°C |
ZM241385
pubchem
|
Antagonist | 2.7 | Inactive | 10.1038/NATURE10750 | 2012-02-01 | ||
| 5WIU | DRD4 | D4 | Dopamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 5.8-6.2 | 20°C |
Nemonapride
pubchem
|
Antagonist | 2.0 | Inactive | 10.1126/SCIENCE.AAN5468 | 2017-10-18 | |
| 5TGZ | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | Transient_transfection | HEK293F | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.4 | 20°C |
SCHEMBL662960
pubchem
|
Antagonist | 2.8 | Inactive | 10.1016/J.CELL.2016.10.004 | 2016-11-02 | |
| 4Z9G | CRFR1 | CRF1 | Corticotropin-releasing factor | B1 (Secretin) | Human | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-5.5 | 23°C |
CP-376395
pubchem
|
Antagonist | 3.2 | Inactive | 10.2174/1874467210666170110114727 | 2016-06-29 | |
| 6HLP | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Netupitant
pubchem
chembl_ligand
|
Antagonist | 2.2 | Inactive | 10.1038/S41467-018-07939-8 | 2019-01-16 | |
| 2PED | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drop | 5 chems | 6.4-6.4 | 283 K |
retinal
gtoplig
|
Inverse agonist | 3.0 | Inactive | 10.1529/BIOPHYSJ.107.108225 | 2007-10-30 | ||
| 6E59 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L760735
pubchem
|
Antagonist | 3.4 | Inactive | 10.1073/PNAS.1812717115 | 2018-12-12 | |
| 4LDE | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | 7.7 MAG | 5 chems | 6.5-6.5 | 20°C |
BI167107
pubchem
|
Agonist | 2.8 | Active | 10.1038/NATURE12572 | 2013-09-25 | |
| 6D26 | PD2R2 | DP2 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
fevipiprant
pubchem
|
Antagonist | 2.8 | Inactive | 2018-10-03 | ||
| 5OLZ | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
4-(3-amino-5-phenyl-...
|
Antagonist | 1.9 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
| 4ZUD | AGTR1 | AT1 | Angiotensin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-5.0 | 20°C |
OLM
|
Inverse agonist | 2.8 | Inactive | 10.1074/JBC.M115.689000 | 2015-10-07 | |
| 5D5A | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.5-7.0 | 20°C |
Carazolol
pubchem
|
Inverse agonist | 2.5 | Inactive | 10.1107/S2059798315021683 | 2016-01-13 | |
| 4OR2 | GRM1 | mGlu1 | Metabotropic glutamate | C (Glutamate) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C |
FITM
pubchem
|
NAM | 2.8 | Inactive | 10.1126/SCIENCE.1249489 | 2014-03-19 | |
| 4OO9 | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 6.8-6.8 | 20°C |
Mavoglurant
pubchem
|
NAM | 2.6 | Inactive | 10.1038/NATURE13396 | 2014-07-02 | |
| 4EA3 | OPRX | NOP | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.4-6.4 | 20°C |
C-24
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/NATURE11085 | 2012-04-25 | |
| 5IUA | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20 |
2-(Furan-2-Yl)-N~5~-...
pubchem
|
Agonist | 2.2 | Inactive | 10.1021/ACS.JMEDCHEM.6B00653 | 2016-06-29 | |
| 5K2D | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM241385
pubchem
|
Antagonist | 1.9 | Inactive | 10.1126/SCIADV.1600292 | 2016-09-21 | |
| 3C9M | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | NA | NA | 1 chemicals | 1 steps | NA | NA | NA | 1 chems | 0.0-0.0 | NA |
retinal
gtoplig
|
Inverse agonist | 3.4 | Inactive | 10.1107/S0907444908017162 | 2008-08-05 | |
| 6H7J | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ISOPRENALINE
pubchem
|
Agonist | 2.8 | Active | 10.1101/436212 | 2018-10-17 | |
| 2Y04 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 6 chems | 9.0-9.0 | 4°C |
Levalbuterol
pubchem
|
Agonist (partial) | 3.1 | Inactive | 10.1038/NATURE09746 | 2011-01-12 | ||
| 5NDZ | PAR2 | PAR2 | Proteinase-activated | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-6.2 | 20°C |
AZ3451
pubchem
|
Antagonist | 3.6 | Intermediate | 10.1038/NATURE22309 | 2017-05-03 | |
| 6M9T | PE2R3 | EP3 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
misoprostol-FA
pubchem
|
Antagonist | 2.5 | Intermediate | 10.1038/S41589-018-0160-Y | 2018-12-05 | |
| 5WB1 | Q80KM9 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.0-6.0 | 16-20°C | N/A | N/A | 3.5 | Active | 10.7554/ELIFE.35850 | 2018-06-13 | |
| 6AK3 | PE2R3 | EP3 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Prostaglandin E2
pubchem
chembl_ligand
|
Agonist | 2.9 | Active | 10.1038/S41589-018-0171-8 | 2018-12-05 | |
| 5NDD | PAR2 | PAR2 | Proteinase-activated | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-6.2 | 20°C |
GTPL9585
pubchem
|
Antagonist | 2.8 | Intermediate | 10.1038/NATURE22309 | 2017-05-03 | |
| 6FK7 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
(2~{R},3~{R})-2-(4-c...
|
Agonist | 2.6 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
| 3NYA | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 21-23°C |
(-)-Alprenolol
pubchem
|
Antagonist | 3.2 | Inactive | 10.1021/JA105108Q | 2010-08-11 | |
| 5WQC | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 9 chemicals | 9 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 4 chems | 5.8-6.2 | 20°C |
EMPA
pubchem
chembl_ligand
|
Antagonist | 2.0 | Inactive | 10.1016/J.STR.2017.11.005 | 2017-11-29 | |
| 5OM4 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
4-(3-amino-5-phenyl-...
|
Antagonist | 2.0 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
| 5DSG | ACM4 | M4 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.5-8.0 | 20°C |
Tiotropium
pubchem
|
Antagonist | 2.6 | Inactive | 10.1038/NATURE17188 | 2016-03-16 | |
| 2YCZ | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | NA | 3 chems | 6.9-7.3 | NA |
timolol
pubchem
|
Antagonist | 3.7 | Inactive | 10.1073/PNAS.1100185108 | 2011-06-01 | ||
| 5ZKB | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AF-DX 384
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/S41589-018-0152-Y | 2018-11-21 | |
| 5GLI | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.3-6.3 | 20°C | N/A | N/A | 2.5 | Inactive | 10.1038/NATURE19319 | 2016-09-07 | |
| 6D35 | Q98SW5 | SMO | Frizzled | F (Frizzled) | African clawed frog | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.5 | 20°C | N/A | N/A | 3.9 | Inactive | 10.1016/J.CELL.2018.04.029 | 2018-05-23 | |
| 5TZY | FFAR1 | FFA1 | Free fatty acid | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.3-6.8 | 20°C |
(2s,3r)-3-Cyclopropy...
pubchem
UNII-11612L5SPI pubchem |
AgonistAgonist | 3.2 | Intermediate | 10.1038/NSMB.3417 | 2017-06-07 | |
| 4LDL | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | 7.7 MAG | 5 chems | 6.5-6.5 | 20°C |
hydroxybenzylisoprot...
pubchem
|
Agonist | 3.1 | Active | 10.1038/NATURE12572 | 2013-09-25 | |
| 5VEW | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.2-6.6 | 20°C |
97Y
pubchem
|
Antagonist | 2.7 | Inactive | 10.1038/NATURE22378 | 2017-05-24 | |
| 3VW7 | PAR1 | PAR1 | Proteinase-activated | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.5 | 20°C |
Vorapaxar
pubchem
|
Antagonist | 2.2 | Intermediate | 10.1038/NATURE11701 | 2012-12-12 | |
| 5UVI | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-5.0 | 20°C |
ZM241385
pubchem
|
Antagonist | 3.2 | Inactive | 10.1107/S205225251700570X | 2017-05-24 | |
| 2YDO | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 4 chemicals | 4 steps | vapour diffusion | sitting drop | 5 chems | 7.6-7.6 | 4°C |
adenosine
pubchem
|
Agonist | 3.0 | Intermediate | 10.1038/NATURE10136 | 2011-05-18 | ||
| 6FFH | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-6.8 | 20°C |
Fenobam
pubchem
|
NAM | 2.7 | Inactive | 10.1021/ACS.JMEDCHEM.7B01722 | 2018-03-07 | |
| 5JQH | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | 7.7 MAG | 5 chems | 7.5-7.5 | 23°C |
Carazolol
pubchem
|
Inverse agonist | 3.2 | Inactive | 10.1038/NATURE18636 | 2016-07-13 | |
| 5VEX | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.8 | 20°C |
4-{[(4-Cyclohexylphe...
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/NATURE22378 | 2017-05-17 | |
| 4GRV | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C |
Neurotensin(8-13)
pubchem
|
Agonist | 2.8 | Intermediate | 10.1038/NATURE11558 | 2012-10-17 | |
| 3ZPR | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 3 chems | 9.0-9.0 | 4°C |
4-methyl-2-(piperazi...
pubchem
|
Antagonist | 2.7 | Inactive | 10.1021/JM400140Q | 2013-04-03 | ||
| 6H7N | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Xamoterol
pubchem
|
Agonist | 2.5 | Active | 10.1101/436212 | 2018-10-17 | |
| 2J4Y | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Transient_transfection | COS1 | Mammalian | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 3 chems | 7.5-7.5 | 4°C |
retinal
gtoplig
|
Inverse agonist | 3.4 | Inactive | 10.1016/J.JMB.2007.03.007 | 2007-09-25 | ||
| 3OE6 | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20°C |
IT1t
pubchem
|
Antagonist | 3.2 | Inactive | 10.1126/SCIENCE.1194396 | 2010-10-27 | |
| 5EN0 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Stable_cells | HEK293S(TetR)GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Sitting drop | 4 chems | 5.0-5.0 | 4°C |
retinal
gtoplig
|
Inverse agonist | 2.8 | Active | 10.15252/EMBR.201642671 | 2016-08-10 | ||
| 4NC3 | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 8.0-8.0 | 20°C |
ERGOTAMINE
pubchem
|
Agonist | 2.8 | Intermediate | 10.1126/SCIENCE.1244142 | 2013-12-18 | |
| 6FKA | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
(2~{S})-2-(3,4-dichl...
|
Agonist | 2.7 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
| 6FUF | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal
pubchem
|
Inverse agonist | 3.1 | Active | 10.1126/SCIADV.AAT7052 | 2018-10-03 | |
| 4BV0 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | NA | E. coli BL21(DE3) | Bacteria | 3 chemicals | 3 steps | vapour diffusion | sitting drops | 5 chems | 9.4-9.4 | 4°C |
CHEMBL342252
pubchem
|
Agonist | 3.1 | Inactive | 10.1073/PNAS.1317903111 | 2014-01-29 | ||
| 3RFM | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 6 chems | 8.0-8.8 | 4°C |
caffeine
pubchem
|
Antagonist | 3.6 | Inactive | 10.1016/J.STR.2011.06.014 | 2011-09-07 | ||
| 4U15 | ACM3 | M3 | Acetylcholine (muscarinic) | A (Rhodopsin) | Rat | Baculovirus | Sf9 | Insect | 9 chemicals | 9 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.5-7.5 | 298 K |
Tiotropium
pubchem
|
Antagonist | 2.8 | Inactive | 10.1016/J.STR.2014.08.022 | 2014-11-26 | |
| 5YWY | PE2R4 | EP4 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ONO-AE3-208
pubchem
|
Antagonist | 3.2 | Inactive | 10.1038/S41589-018-0131-3 | 2018-12-05 | |
| 4X1H | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 3 chems | 5.0-6.5 | 4°C |
69984-73-2
pubchem
|
Inverse agonist | 2.3 | Active | 10.1016/J.STR.2015.09.015 | 2015-11-04 | ||
| 5O9H | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 5.5-6.0 | 22.5°C |
NDT 9513727
pubchem
|
Antagonist | 2.7 | Inactive | 10.1038/NATURE25025 | 2018-01-10 | |
| 4BEY | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Stable_cells | HEK293S(TetR)GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 4 chems | 4.5-4.5 | 20°C | N/A | N/A | 2.9 | Active | 10.1038/EMBOR.2013.44 | 2013-05-08 | ||
| 5N2S | AA1R | A1 | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 7.5-7.5 | 20°C |
PSB36
pubchem
|
Agonist | 3.3 | Inactive | 10.1016/J.STR.2017.06.012 | 2017-07-26 | |
| 5LWE | CCR9 | CCR9 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.9-8.0 | 20°C |
Vercirnon
pubchem
|
Antagonist | 2.8 | Inactive | 10.1038/NATURE20606 | 2016-12-07 | |
| 5WF5 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-5.0 | 20°C |
UK-432,097
pubchem
|
Agonist | 2.6 | Intermediate | 10.1016/J.STR.2017.12.013 | 2018-02-21 | |
| 6DRY | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Methylergonovine
pubchem
chembl_ligand
|
Agonist | 2.9 | Intermediate | 10.1038/S41594-018-0116-7 | 2018-08-29 | |
| 3CAP | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drop | 4 chems | 5.6-5.6 | 4°C | N/A | N/A | 2.9 | Active | 10.1038/NATURE07063 | 2008-06-24 | ||
| 5L7I | SMO | SMO | Frizzled | F (Frizzled) | Human | Transient_transfection | HEK293S(TetR)-GnTI- | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 8 chems | 6.0-6.0 | 20°C |
Vismodegib
pubchem
|
Antagonist | 3.3 | Inactive | 10.1038/NATURE18934 | 2016-07-20 | |
| 2Y02 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 6 chems | 9.0-9.0 | 4°C |
Carmoterol
pubchem
|
Agonist | 2.6 | Inactive | 10.1038/NATURE09746 | 2011-01-12 | ||
| 6H7L | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
DOBUTAMINE
pubchem
|
Agonist | 2.7 | Active | 10.1101/436212 | 2018-10-17 | |
| 6C1Q | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.5-6.5 | 10°C |
PMX53
pubchem
chembl_ligand
H94Wrl71FP pubchem |
AntagonistAntagonist | 2.9 | Inactive | 10.1038/S41594-018-0067-Z | 2018-05-30 | |
| 4UG2 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 3 chems | 7.0-7.0 | 22°C |
Cgs 21680
pubchem
|
Agonist | 2.6 | Intermediate | 10.1124/MOL.114.097360 | 2015-04-08 | |
| 5NM2 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM241385
pubchem
|
Antagonist | 2.0 | Inactive | 10.1038/S41467-017-00630-4 | 2017-09-27 | |
| 6B73 | OPRK | κ | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 6.5-7.0 | 20°C |
MP1104
pubchem
|
Agonist | 3.1 | Active | 10.1016/J.CELL.2017.12.011 | 2018-01-17 | |
| 5NLX | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM 241385
pubchem
|
Antagonist | 2.1 | Inactive | 10.1038/S41467-017-00630-4 | 2017-09-27 | |
| 5U09 | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 9 chemicals | 9 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20°C |
Taranabant
pubchem
|
Inverse agonist | 2.6 | Inactive | 10.1038/NATURE20613 | 2016-12-07 | |
| 5IU8 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20°C |
CHEMBL3934661
pubchem
|
Agonist | 2.0 | Inactive | 2016-06-29 | ||
| 5G53 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | vapour diffusion | Sitting drop | 6 chems | 5.7-5.7 | 4°C |
NECA
pubchem
|
Agonist | 3.4 | Active | 10.1038/NATURE18966 | 2016-08-03 | ||
| 6HLL | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CP-99,994
pubchem
chembl_ligand
|
Antagonist | 3.3 | Inactive | 10.1038/S41467-018-07939-8 | 2019-01-16 | |
| 2I35 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 2 chemicals | 2 steps | vapour diffusion | sitting drops | 5 chems | 7.0-8.0 | 5°C |
retinal
gtoplig
|
Inverse agonist | 3.8 | Inactive | 10.1073/PNAS.0608022103 | 2006-10-17 | ||
| 4JKV | SMO | SMO | Frizzled | F (Frizzled) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 6 chems | 7.4-7.4 | 20°C |
LY2940680
pubchem
|
Antagonist | 2.5 | Inactive | 10.1038/NATURE12167 | 2013-04-24 | |
| 4ZWJ | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Human | Transient_transfection | HEK293S(TetR)-GnTI- | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monopalmitolein (9.7 MAG) | 5 chems | 5.0-5.0 | 20°C | N/A | N/A | 3.3 | Active | 10.1038/NATURE14656 | 2015-07-29 | |
| 6IBL | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Formoterol
pubchem
chembl_ligand
|
Agonist | 2.7 | Active | 2019-01-09 | ||
| 2X72 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Stable_cells | HEK293S-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 3 chems | 4.5-4.5 | 4°C |
retinal
gtoplig
|
Agonist | 3.0 | Active | 10.1038/NATURE09795 | 2011-03-16 | ||
| 4PXF | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 3 chems | 6.0-6.0 | 4°C | N/A | N/A | 2.8 | Active | 10.1038/NCOMMS5801 | 2014-09-17 | ||
| 5NJ6 | PAR2 | PAR2 | Proteinase-activated | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 5.5-6.2 | 20°C | N/A | N/A | 4.0 | Intermediate | 10.1038/NATURE22309 | 2017-05-03 | |
| 5MZJ | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20 |
Theophylline
pubchem
|
Antagonist | 2.0 | Inactive | 10.1016/J.STR.2017.06.012 | 2017-07-26 | |
| 4Z34 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.5-5.5 | 20°C |
ONO-9780307
pubchem
|
Antagonist | 3.0 | Inactive | 10.1016/J.CELL.2015.06.002 | 2015-06-03 | |
| 5K2C | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM241385
pubchem
|
Antagonist | 1.9 | Inactive | 10.1126/SCIADV.1600292 | 2016-09-21 | |
| 3NY8 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.5-8.0 | 20°C |
AC1NSK5N
pubchem
|
Inverse agonist | 2.8 | Inactive | 10.1021/JA105108Q | 2010-08-11 | |
| 6A94 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Zotepine
pubchem
chembl_ligand
|
Antagonist | 2.9 | Inactive | 10.1038/S41594-018-0180-Z | 2019-02-13 | |
| 4A4M | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Stable_cells | HEK293T | Mammalian | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 3 chems | 4.5-4.5 | 4°C |
retinal
gtoplig
|
Agonist | 3.3 | Active | 10.1073/PNAS.1114089108 | 2012-01-25 | ||
| 4XNV | P2RY1 | P2Y1 | P2Y | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.5-6.5 | 20°C |
BPTU
pubchem
|
Antagonist | 2.2 | Intermediate | 10.1038/NATURE14287 | 2015-04-01 | |
| 2G87 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 6.5-7.5 | 283 K |
retinal
gtoplig
|
Agonist | 2.6 | Inactive | 10.1002/ANIE.200600595 | 2006-09-02 | ||
| 6D32 | Q98SW5 | SMO | Frizzled | F (Frizzled) | African clawed frog | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.5 | 20°C |
Cyclopamine
pubchem
|
Antagonist | 3.8 | Inactive | 10.1016/J.CELL.2018.04.029 | 2018-05-23 | |
| 5UIG | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | vapour diffusion | Sitting drop | 6 chems | 7.0-7.0 | 20°C |
J3.651.884G
pubchem
|
Antagonist | 3.5 | Inactive | 10.1073/PNAS.1621423114 | 2017-02-08 | ||
| 4BUO | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | NA | E. coli BL21(DE3) | Bacteria | 6 chemicals | 6 steps | vapour diffusion | Sitting drop | 5 chems | 9.4-9.4 | 4°C |
CHEMBL342252
pubchem
|
Agonist | 2.8 | Inactive | 10.1073/PNAS.1317903111 | 2014-01-29 | ||
| 2I36 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 2 chemicals | 2 steps | vapour diffusion | sitting drops | 5 chems | 7.0-8.0 | 5°C | N/A | N/A | 4.1 | Inactive | 10.1073/PNAS.0608022103 | 2006-10-17 | ||
| 5YC8 | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-methyl scopolamine
pubchem
|
Antagonist | 2.5 | Inactive | 10.1038/S41589-018-0152-Y | 2018-11-21 | |
| 5CGC | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-6.8 | 20°C |
CHEMBL3603915
pubchem
|
NAM | 3.1 | Inactive | 10.1021/ACS.JMEDCHEM.5B00892 | 2015-08-12 | |
| 5WB2 | Q80KM9 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 6.0-6.0 | 16-20°C |
CX3CL1
|
Agonist | 3.5 | Active | 10.7554/ELIFE.35850 | 2018-06-13 | |
| 4J4Q | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drop | 3 chems | 5.2-6.0 | 4°C | N/A | N/A | 2.7 | Active | 10.1002/ANIE.201302374 | 2013-10-30 | ||
| 5VRA | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 4.6-5.0 | 20°C |
ZM241385
pubchem
|
Antagonist | 2.4 | Inactive | 10.1038/NPROT.2017.135 | 2017-12-13 | |
| 3DQB | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | hanging drops | 5 chems | 5.9-6.1 | 10°C | N/A | N/A | 3.2 | Active | 10.1038/NATURE07330 | 2008-09-23 | ||
| 3UZC | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 6 chems | 8.0-8.0 | 4°C |
T4E
|
Antagonist | 3.3 | Inactive | 10.1021/JM201376W | 2012-03-21 | ||
| 4GPO | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 3.6-4.0 | 18°C | N/A | N/A | 3.5 | Inactive | 10.1038/NSMB.2504 | 2013-02-27 | ||
| 5V57 | SMO | SMO | Frizzled | F (Frizzled) | Human | Transient_transfection | HEK293F | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
N-methyl-N-[1-[4-(2-...
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/NCOMMS15383 | 2017-05-24 | |
| 6FJ3 | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ePTH
|
Agonist | 2.5 | Inactive | 10.1038/S41594-018-0151-4 | 2018-11-21 | |
| 5ZKQ | PTAFR | PAF | Platelet-activating factor | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ABT-491
pubchem
chembl_ligand
|
Inverse agonist | 2.9 | Intermediate | 10.1038/S41594-018-0068-Y | 2018-06-20 | |
| 5XSZ | Q08BG4 | LPA6 | Lysophospholipid (LPA) | A (Rhodopsin) | Zebrafish | Baculovirus | Sf9 | Insect | 8 chemicals | 8 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 6 chems | 6.0-6.0 | 20°C | N/A | N/A | 3.2 | Active | 10.1038/NATURE23448 | 2017-08-16 | |
| 2R4S | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | vapour diffusion | hanging drop | 5 chems | 6.5-7.5 | 22°C | N/A | N/A | 3.4 | Inactive | 10.1038/NATURE06325 | 2007-11-06 | ||
| 4MQS | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.2-7.9 | 20°C |
iperoxo
pubchem
|
Agonist | 3.5 | Active | 10.1038/NATURE12735 | 2013-11-27 | |
| 5K2B | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM241385
pubchem
|
Antagonist | 2.5 | Inactive | 10.1126/SCIADV.1600292 | 2016-09-21 | |
| 4GBR | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 6.5-6.5 | 20°C |
(S)-Carazolol
pubchem
|
Inverse agonist (partial) | 4.0 | Inactive | 10.1371/JOURNAL.PONE.0046039 | 2012-10-24 | |
| 4BEZ | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Stable_cells | HEK293S-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 4 chems | 4.5-4.5 | 20°C | N/A | N/A | 3.3 | Active | 10.1038/EMBOR.2013.44 | 2013-04-24 | ||
| 3PWH | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 6 chems | 8.0-8.8 | 4°C |
ZM241385
pubchem
|
Antagonist | 3.3 | Inactive | 10.1016/J.STR.2011.06.014 | 2011-09-07 | ||
| 5TE3 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drop | 4 chems | 5.2-6.6 | 4°C | N/A | N/A | 2.7 | Active | 10.1073/PNAS.1617446114 | 2017-03-15 | ||
| 6GPS | CCR2 | CCR2 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MK-0812
pubchem
|
Antagonist | 3.3 | Inactive | 10.1016/J.STR.2018.10.027 | 2019-01-02 | |
| 6FKD | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
5-chloranyl-2-(2-oxi...
|
Agonist | 2.5 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
| 3V2Y | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.8-7.8 | 20°C |
W146
pubchem
|
Antagonist | 2.8 | Inactive | 10.1126/SCIENCE.1215904 | 2012-02-15 | |
| 4DAJ | ACM3 | M3 | Acetylcholine (muscarinic) | A (Rhodopsin) | Rat | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.5-7.5 | 22°C |
Tiotropium
pubchem
|
Antagonist | 3.4 | Inactive | 10.1038/NATURE10867 | 2012-02-22 | |
| 5KW2 | FFAR1 | FFA1 | Free fatty acid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 8.5-8.5 | 20°C |
(3~{S})-3-cyclopropy...
|
Antagonist | 2.8 | Intermediate | 10.1038/S41467-017-01240-W | 2018-05-02 | |
| 3PXO | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 3 chems | 5.0-5.8 | 4°C |
retinal
gtoplig
|
Agonist | 3.0 | Active | 10.1038/NATURE09789 | 2011-03-09 | ||
| 5ZBQ | NPY1R | Y1 | Neuropeptide Y | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 7.4-8.0 | 19–22 °C |
UR-MK299
pubchem
|
Antagonist | 2.7 | Inactive | 10.1038/S41586-018-0046-X | 2018-04-25 | |
| 2Z73 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Japanese flying squid | NA | Native | Squid | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 5 chems | 6.4-6.4 | 4°C |
retinal
gtoplig
|
Inverse agonist | 2.5 | Inactive | 10.1038/NATURE06925 | 2008-05-13 | ||
| 4EIY | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-5.0 | 20°C |
ZM241385
pubchem
|
Antagonist | 1.8 | Inactive | 10.1126/SCIENCE.1219218 | 2012-07-25 | |
| 2HPY | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 5.9-6.1 | 283 K |
retinal
gtoplig
|
Agonist | 2.8 | Inactive | 10.1073/PNAS.0601765103 | 2006-08-22 | ||
| 5IUB | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20°C |
CHEMBL184061
pubchem
|
Agonist | 2.1 | Inactive | 10.1021/ACS.JMEDCHEM.6B00653 | 2016-06-29 | |
| 3ODU | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20°C |
IT1t
pubchem
|
Antagonist | 2.5 | Inactive | 10.1126/SCIENCE.1194396 | 2010-10-27 | |
| 5DGY | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Human | Transient_transfection | HEK293S | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monopalmitolein (9.7 MAG) | 5 chems | 5.0-5.0 | 20°C | N/A | N/A | 7.7 | Active | 10.1038/SDATA.2016.21 | 2016-03-23 | |
| 6DS0 | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY266097
pubchem
|
Antagonist | 3.2 | Intermediate | 10.1038/S41594-018-0116-7 | 2018-08-29 | |
| 5DHG | OPRX | NOP | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.4-6.4 | 20°C | N/A | N/A | 3.0 | Inactive | 10.1016/J.STR.2015.07.024 | 2015-10-21 | |
| 5XR8 | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | Transient_transfection | HEK293T | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.2-6.2 | 20°C |
8D0
|
Agonist | 3.0 | Active | 10.1038/NATURE23272 | 2017-07-12 | |
| 3D4S | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C |
timolol
pubchem
|
Inverse agonist | 2.8 | Inactive | 10.1016/J.STR.2008.05.001 | 2008-06-17 | |
| 5X93 | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C |
K-8794
pubchem
|
Antagonist | 2.2 | Inactive | 10.1038/NSMB.3450 | 2017-08-16 | |
| 6DDE | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | Cryo-EM | Gatan K2 Summit direct electron camera , 300kV | 5 chems | 7.5-7.5 | 4°C |
DAMGO
pubchem
chembl_ligand
|
Agonist | 3.5 | Active | 10.1038/S41586-018-0219-7 | 2018-06-13 | ||
| 5XPR | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C | N/A | N/A | 3.6 | Inactive | 10.1038/NSMB.3450 | 2017-08-16 | |
| 6BQH | 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
Ritanserin
pubchem
|
Inverse agonist | 2.7 | Inactive | 10.1016/J.CELL.2018.01.001 | 2018-02-14 | |
| 4LDO | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | 7.7 MAG | 5 chems | 6.5-6.5 | 20°C |
epinephrine
pubchem
|
Agonist | 3.2 | Active | 10.1038/NATURE12572 | 2013-09-25 | |
| 6HLO | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Aprepitant
pubchem
chembl_ligand
|
Antagonist | 2.4 | Inactive | 10.1038/S41467-018-07939-8 | 2019-01-16 | |
| 6GPX | CCR2 | CCR2 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MK-0812
pubchem
|
Antagonist | 2.7 | Inactive | 10.1016/J.STR.2018.10.027 | 2019-01-02 | |
| 2YCX | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | NA | 3 chems | 6.9-7.3 | NA |
(S)-Cyanopindolol
pubchem
|
Antagonist | 3.3 | Inactive | 10.1073/PNAS.1100185108 | 2011-06-01 | ||
| 6AQF | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Pichia Pastoris | P. pastoris SMD1163 | Yeast | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-5.0 | 20°C |
ZM241385
pubchem
|
Antagonist | 2.5 | Inactive | 10.1016/J.CELL.2017.12.004 | 2018-01-10 | |
| 6BQG | 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
Ergotamine
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.CELL.2018.01.001 | 2018-02-14 | |
| 5YQZ | GLR | glucagon | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | MAG 7.8 | 5 chems | 8.0-8.0 | 20°C |
NNC1702
|
Partial agonist | 3.0 | Inactive | 10.1038/NATURE25153 | 2018-01-17 | |
| 6DO1 | AGTR1 | AT1 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Angiotensin-like pep...
|
Agonist | 2.9 | Active | 10.1016/J.CELL.2018.12.006 | 2019-01-30 | |
| 5T04 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 8.5-9.0 | 20°C |
CHEMBL342252
pubchem
|
Agonist | 3.3 | Active | 10.1038/SREP38564 | 2016-12-21 | |
| 2RH1 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.8-6.8 | 21-23°C |
Carazolol
pubchem
|
Inverse agonist | 2.4 | Inactive | 10.1126/SCIENCE.1150577 | 2007-10-30 | |
| 3PBL | DRD3 | D3 | Dopamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.5-7.5 | 20°C |
Eticlopride
pubchem
|
Antagonist | 2.9 | Inactive | 10.1126/SCIENCE.1197410 | 2010-11-03 | |
| 5XRA | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | Transient_transfection | HEK293T | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.4-6.4 | 20°C |
CHEMBL1683648
pubchem
|
Agonist | 2.8 | Active | 10.1038/NATURE23272 | 2017-07-12 | |
| 4K5Y | CRFR1 | CRF1 | Corticotropin-releasing factor | B1 (Secretin) | Human | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-5.5 | 22.5°C |
CP-376395
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/NATURE12357 | 2013-07-17 | |
| 4DKL | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | Baculovirus | Sf9 | Insect | 12 chemicals | 12 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C |
BF0
|
Antagonist | 2.8 | Inactive | 10.1038/NATURE10954 | 2012-03-21 | |
| 3UZA | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 6 chems | 8.0-8.0 | 4°C |
CHEMBL2024115
pubchem
|
Antagonist | 3.3 | Inactive | 10.1021/JM201376W | 2012-03-21 | ||
| 4Z35 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.5-5.5 | 20°C |
ONO-9910539
pubchem
|
Antagonist | 2.9 | Inactive | 10.1016/J.CELL.2015.06.002 | 2015-06-03 | |
| 5UNF | AGTR2 | AT2 | Angiotensin | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 8.0-8.0 | 20°C |
CHEMBL289472
pubchem
|
Antagonist | 2.8 | Active | 10.1038/NATURE22035 | 2017-04-05 | |
| 5K2A | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM241385
pubchem
|
Antagonist | 2.5 | Inactive | 10.1126/SCIADV.1600292 | 2016-09-21 | |
| 4PY0 | P2Y12 | P2Y12 | P2Y | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-6.0 | 20°C |
2-Mesatp
pubchem
|
Agonist (partial) | 3.1 | Intermediate | 10.1038/NATURE13288 | 2014-04-30 | |
| 6N51 | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Quisqualic acid
pubchem
|
Agonist | 4.0 | Intermediate | 10.1038/S41586-019-0881-4 | 2019-01-23 | |
| 5XF1 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C |
4-{[(4-Cyclohexylphe...
pubchem
|
Antagonist | 3.2 | Inactive | 10.1038/NATURE22363 | 2017-05-24 | |
| 6D9H | AA1R | A1 | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | Cryo-EM | Volta phase plate(FEI), FEI Titan Krios@300kV, Gatan K2 Summit direct electron camera , Gatan Quantum energy filter | 6 chems | 7.4-7.4 | 4°C |
Adenosine
pubchem
|
Agonist | 3.6 | Active | 10.1038/S41586-018-0236-6 | 2018-06-20 | ||
| 6IIV | TA2R | TP | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Daltroban
pubchem
chembl_ligand
|
Antagonist | 3.0 | Inactive | 10.1038/S41589-018-0170-9 | 2018-12-19 | |
| 5CXV | ACM1 | M1 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 8.0-8.0 | 20°C |
CHEMBL258622
pubchem
|
Antagonist | 2.7 | Inactive | 10.1038/NATURE17188 | 2016-03-09 | |
| 4QIM | SMO | SMO | Frizzled | F (Frizzled) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 7.2-7.2 | 20°C |
AntaXV
pubchem
|
Antagonist | 2.6 | Inactive | 10.1038/NCOMMS5355 | 2014-07-23 | |
| 4QIN | SMO | SMO | Frizzled | F (Frizzled) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 6 chems | 7.2-7.2 | 20°C |
SAG1.5
|
Agonist | 2.6 | Inactive | 10.1038/NCOMMS5355 | 2014-07-23 | |
| 4U16 | ACM3 | M3 | Acetylcholine (muscarinic) | A (Rhodopsin) | Rat | Baculovirus | Sf9 | Insect | 9 chemicals | 9 steps | sponge mesophase | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.5-7.5 | 298 K |
methscopolamine
pubchem
|
Antagonist | 3.7 | Inactive | 10.1016/J.STR.2014.08.022 | 2014-11-26 | |
| 2VT4 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Common turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | hanging drop | 4 chems | 6.9-7.3 | 18°C |
(S)-Cyanopindolol
pubchem
|
Antagonist | 2.7 | Inactive | 10.1038/NATURE07101 | 2008-06-24 | ||