Experiment Browser
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| RECEPTOR | EXPRESSION | SOLUBILIZATION | PURIFICATION | STRUCTURE DETERMINATION | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | pH | Temp | Resolution | Reference | Date | ||||||||||||||||||
| 7F8U | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lintitript
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.8 | Inactive | 10.1038/S41589-021-00866-8 | 2021-10-13 | |
| 4RWA | OPRD | δ | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.0-6.0 | 20°C |
DIPP-NH2
|
Antagonist | 3.3 | Inactive | 10.1038/NSMB.2965 | 2015-01-14 | |
| 7VL9 | CCR1 | CCR1 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCL15(26-92)
|
Agonist | 2.6 | Active | 10.1038/S41589-021-00918-Z | 2022-03-23 | |
| 7RKF | US28 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Fractalkine
pubchem
|
Agonist | 4.0 | Active | 10.1126/SCIADV.ABL5442 | 2022-01-26 | |
| 3RZE | HRH1 | H1 | Histamine | A (Rhodopsin) | Human | Pichia Pastoris | P. pastoris SMD1163 | Yeast | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 4.5-4.5 | 20-22°C |
doxepin
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
|
Antagonist | 3.1 | Inactive | 10.1038/NATURE10236 | 2011-06-15 | |
| 2Y00 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 6 chems | 8.5-8.5 | 4°C |
Dobutamine
pubchem
|
Agonist (partial) | 2.5 | Inactive | 10.1038/NATURE09746 | 2011-01-12 | ||
| 5D5A | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.5-7.0 | 20°C |
Carazolol
pubchem
|
Inverse agonist | 2.5 | Inactive | 10.1107/S2059798315021683 | 2016-01-13 | |
| 6PS5 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
propranolol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
gtoplig
chembl_ligand
pubchem
pubchem
pubchem
|
Antagonist | 2.9 | Inactive | 10.1107/S2052252519013137 | 2019-11-13 | |
| 6FK7 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
(2~{S})-2-(4-chlorop...
pubchem
|
Agonist | 2.6 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
| 7F4D | MSHR | MC1 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
INTERMEDINE
chembl_ligand
pubchem
pubchem
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41422-021-00557-Y | 2021-09-08 | |
| 6ZDV | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-Methyl-3-(4-methyl...
pubchem
|
Antagonist | 2.1 | Inactive | 10.1002/ANIE.202003788 | 2020-09-16 | |
| 7RBT | GIPR | GIP | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
tirzepatide
pubchem
gtoplig
2-fluoro-4-[(1R)-6-m... pubchem |
AgonistPAM | 3.1 | Active | 10.1073/PNAS.2116506119 | 2022-04-13 | |
| 7D77 | AGRG3 | ADGRG3 | ADGRG | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
HYDROCORTISONE
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 2021-02-03 | ||
| 6NBH | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Long-acting parathyr...
|
Agonist | 3.5 | Active | 10.1126/SCIENCE.AAV7942 | 2019-04-17 | |
| 6M9T | PE2R3 | EP3 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Misoprostol-FA
pubchem
|
Agonist | 2.5 | Active | 10.1038/S41589-018-0160-Y | 2018-12-05 | |
| 5IU8 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20°C |
CHEMBL3934661
chembl_ligand
pubchem
|
Antagonist | 2.0 | Inactive | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | |
| 7SF8 | AGRG1 | ADGRG1 | ADGRG | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.7 | Active | 10.1038/S41586-022-04575-7 | 2022-04-27 | |
| 7RMI | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 3.2 | Active | 10.1038/S41589-021-00890-8 | 2021-11-03 | |
| 2Y01 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 6 chems | 9.0-9.0 | 4°C |
Dobutamine
pubchem
|
Agonist (partial) | 2.6 | Inactive | 10.1038/NATURE09746 | 2011-03-30 | ||
| 4GRV | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C |
JMV431
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1038/NATURE11558 | 2012-10-17 | |
| 6DDE | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | Cryo-EM | Gatan K2 Summit direct electron camera , 300kV | 5 chems | 7.5-7.5 | 4°C |
DAMGO
pubchem
gtoplig
chembl_ligand
chembl_ligand
|
Agonist | 3.5 | Active | 10.1038/S41586-018-0219-7 | 2018-06-13 | ||
| 7M3E | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcium
pubchem
NPS 2143 pubchem gtoplig chembl_ligand drugbank L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem |
AgonistNAMPAM | 3.2 | Inactive | 10.1038/S41586-021-03691-0 | 2021-06-30 | |
| 4DAJ | ACM3 | M3 | Acetylcholine (muscarinic) | A (Rhodopsin) | Rat | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.5-7.5 | 22°C |
tiotropium
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
|
Antagonist | 3.4 | Inactive | 10.1038/NATURE10867 | 2012-02-22 | |
| 6NBF | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Long-acting parathyr...
|
Agonist | 3.0 | Active | 10.1126/SCIENCE.AAV7942 | 2019-04-17 | |
| 6OSA | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JMV449
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 10.1038/S41586-019-1337-6 | 2019-07-10 | |
| 4BEY | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Stable_cells | HEK293S(TetR)GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 4 chems | 4.5-4.5 | 20°C |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1038/EMBOR.2013.44 | 2013-05-08 | ||
| 7D68 | GLP2R | GLP-2 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
glucagon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
pubchem
pubchem
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41422-020-00442-0 | 2020-12-16 | |
| 7VGY | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-iodo-melatonin
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.1 | Active | 2022-03-02 | ||
| 6K1Q | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
IRL 2500
pubchem
gtoplig
chembl_ligand
|
Inverse agonist | 2.7 | Inactive | 10.1038/S42003-019-0482-7 | 2019-07-17 | |
| 4Z9G | CRFR1 | CRF1 | Corticotropin-releasing factor | B1 (Secretin) | Human | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-5.5 | 23°C |
CP 376,395
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.2 | Inactive | 10.2174/1874467210666170110114727 | 2016-06-29 | |
| 7T6U | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
synthetic peptide
|
Agonist | 2.9 | Active | 2022-03-30 | ||
| 3AYN | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Japanese flying squid | NA | Native | Squid | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 5 chems | 6.0-6.0 | 4°C |
Retinal (9-cis)
pubchem
|
Inverse agonist | 2.7 | Inactive | 10.1016/J.JMB.2011.08.044 | 2011-08-17 | ||
| 5N2R | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20 |
PSB36
pubchem
|
Antagonist | 2.8 | Inactive | 10.1016/j.str.2017.06.012 | 2017-07-26 | |
| 5ZBQ | NPY1R | Y1 | Neuropeptide Y | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 7.4-8.0 | 19–22 °C |
CHEMBL3747822
chembl_ligand
chembl_ligand
chembl_ligand
pubchem
|
Antagonist | 2.7 | Inactive | 10.1038/S41586-018-0046-X | 2018-04-25 | |
| 7F4F | MSHR | MC1 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL407070
chembl_ligand
pubchem
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41422-021-00557-Y | 2021-09-08 | |
| 7ARO | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL124345
chembl_ligand
pubchem
|
Agonist (partial) | 3.1 | Inactive | 10.1021/ACS.JMEDCHEM.0C01856 | 2021-04-07 | |
| 5C1M | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 7.5-7.5 | 20°C |
BU72
gtoplig
pubchem
|
Agonist | 2.1 | Active | 10.1038/NATURE14886 | 2015-08-05 | |
| 7E14 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-Tert-butyl-6,7-dic...
pubchem
LY3502970 pubchem gtoplig chembl_ligand |
Ago-PAMAgonist | 2.9 | Active | 10.1038/S41467-021-24058-Z | 2021-07-07 | |
| 6YVR | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JMV431
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.5 | Inactive | 10.1126/sciadv.abe5504 | 2021-02-10 | |
| 7VBH | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Peptide 20
|
Agonist | 3.0 | Active | 10.1038/S41467-022-28683-0 | 2022-04-06 | |
| 4UG2 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 3 chems | 7.0-7.0 | 22°C |
CGS 21680
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 2.6 | Active | 10.1124/mol.114.097360 | 2015-04-08 | |
| 7MBY | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL216166
chembl_ligand
pubchem
|
Agonist | 2.4 | Active | 2021-05-26 | ||
| 6D9H | AA1R | A1 | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | Cryo-EM | Volta phase plate(FEI), FEI Titan Krios@300kV, Gatan K2 Summit direct electron camera , Gatan Quantum energy filter | 6 chems | 7.4-7.4 | 4°C |
adenosine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.6 | Active | 10.1038/S41586-018-0236-6 | 2018-06-20 | ||
| 7T6S | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-(4-chlorophenyl)-N...
pubchem
|
Agonist | 3.0 | Active | 2022-03-30 | ||
| 4J4Q | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drop | 3 chems | 5.2-6.0 | 4°C |
B-Octylglucoside
pubchem
|
unknown | 2.7 | Active | 10.1002/ANIE.201302374 | 2013-10-30 | ||
| 5A8E | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 7.0-7.0 | 20°C |
7-methylcyanopindolo...
pubchem
|
Inverse agonist | 2.4 | Inactive | 10.1124/MOL.115.101030 | 2015-09-30 | |
| 6IIV | TA2R | TP | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
daltroban
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.0 | Intermediate | 10.1038/S41589-018-0170-9 | 2018-12-19 | |
| 6XBL | SMO | SMO | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SAG1.3
pubchem
gtoplig
Cholesterol pubchem |
PAMAgonist | 3.9 | Active | 10.1038/S41589-020-0646-2 | 2020-09-30 | |
| 7MTQ | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 3.7 | Inactive | 10.1038/S41586-021-03680-3 | 2021-07-07 | |
| 6TP4 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ACT-462206
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.0 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
| 7EW4 | S1PR3 | S1P3 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CYM-5541
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.2 | Active | 10.1038/S41422-021-00567-W | 2021-09-29 | |
| 7WC9 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(10~{R},15~{S})-12-[...
pubchem
|
Agonist | 2.5 | Inactive | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | |
| 5LWE | CCR9 | CCR9 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.9-8.0 | 20°C |
vercirnon
pubchem
gtoplig
chembl_ligand
drugbank
|
Allosteric antagonist | 2.8 | Inactive | 10.1038/NATURE20606 | 2016-12-07 | |
| 6ZDR | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL2030687
chembl_ligand
pubchem
|
Antagonist | 1.9 | Inactive | 10.1002/ANIE.202003788 | 2020-09-16 | |
| 7VUH | GP139 | GPR139 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JNJ-63533054
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.2 | Active | 10.1038/S41422-021-00591-W | 2021-12-29 | |
| 4MQT | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.2-7.9 | 20°C |
LY2119620
pubchem
gtoplig
chembl_ligand
iperoxo pubchem gtoplig chembl_ligand |
PAMAgonist | 3.7 | Active | 10.1038/NATURE12735 | 2013-11-27 | |
| 4ZJ8 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.4-5.4 | 20°C |
suvorexant
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Antagonist | 2.8 | Inactive | 10.1038/NSMB.3183 | 2016-03-09 | |
| 6W2Y | GABR1 | GABAB1 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CGP55845
pubchem
1-Stearoyl-2-oleoyl-... pubchem |
Inverse agonistNAM | 3.2 | Inactive | 10.1038/S41586-020-2469-4 | 2020-07-01 | |
| 5X33 | Q9WTK1 | BLT1 | Leukotriene | A (Rhodopsin) | Guinea pig | Pichia Pastoris | P. pastoris SMD1163 | Yeast | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 8.5-9.0 | 4°C |
BIIL 260
pubchem
gtoplig
|
Antagonist | 3.7 | Inactive | 10.1038/NCHEMBIO.2547 | 2018-01-03 | |
| 7CFN | GPBAR | GPBA | Bile acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
INT-777
pubchem
INT-777 pubchem |
AgonistPAM | 3.0 | Active | 10.1038/S41586-020-2569-1 | 2020-09-09 | |
| 3ZPR | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 3 chems | 9.0-9.0 | 4°C |
CHEMBL1559535
chembl_ligand
pubchem
|
Antagonist | 2.7 | Inactive | 10.1021/jm400140q | 2013-04-03 | ||
| 6ME8 | MTR1B | MT2 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-phenylmelatonin
pubchem
|
Agonist | 3.1 | Inactive | 10.1038/S41586-019-1144-0 | 2019-04-24 | |
| 7VV4 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cortistatin 14
pubchem
|
Agonist | 3.0 | Active | 2021-12-01 | ||
| 7SIM | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cyclomethyltryptopha...
pubchem
|
Agonist | 2.7 | Active | 10.1073/PNAS.2115849118 | 2022-01-19 | |
| 6Z4Q | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SR142948A
pubchem
gtoplig
chembl_ligand
|
Inverse agonist | 2.9 | Inactive | 10.1126/sciadv.abe5504 | 2021-02-10 | |
| 7VUY | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PAMP-12
pubchem
|
Agonist | 2.8 | Active | 2021-12-01 | ||
| 7MTB | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (all-trans)
pubchem
|
Agonist | 4.0 | Active | 10.1038/S41586-021-03721-X | 2021-07-07 | |
| 7JJO | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LEVISOPRENALINE
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 2.6 | Active | 10.1016/J.MOLCEL.2020.08.001 | 2020-09-02 | |
| 6KUW | ADA2C | α2C | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(8Ar,12aS,13aR)-12-e...
pubchem
|
Antagonist | 2.8 | Inactive | 2019-12-04 | ||
| 7V3Z | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CP55940
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 3.3 | Active | 10.1021/JACS.1C06847 | 2021-11-24 | |
| 6AK3 | PE2R3 | EP3 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PGE2
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
|
Agonist | 2.9 | Active | 10.1038/S41589-018-0171-8 | 2018-12-05 | |
| 2I36 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 2 chemicals | 2 steps | vapour diffusion | sitting drops | 5 chems | 7.0-8.0 | 5°C |
Apo (no ligand)
|
Apo (no ligand) | 4.1 | Inactive | 10.1073/PNAS.0608022103 | 2006-10-17 | ||
| 7BTS | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(-)-adrenaline
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41422-020-00424-2 | 2020-12-02 | |
| 3C9M | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | NA | NA | 1 chemicals | 1 steps | NA | NA | NA | 1 chems | 0.0-0.0 | NA |
Retinal (11-cis)
pubchem
|
Inverse agonist | 3.4 | Inactive | 10.1107/S0907444908017162 | 2008-08-05 | |
| 7F8Y | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
DEVAZEPIDE
chembl_ligand
pubchem
|
Antagonist | 2.5 | Inactive | 10.1038/S41589-021-00866-8 | 2021-10-13 | |
| 5WKT | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drop | 4 chems | 5.5-5.5 | 7-10°C |
B-Octylglucoside
pubchem
|
unknown | 3.2 | Active | 10.1038/NPROT.2017.135 | 2017-12-13 | ||
| 7FIJ | LSHR | LH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.8 | Inactive | 10.1038/S41586-021-03924-2 | 2021-09-29 | |
| 1F88 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 2 chemicals | 2 steps | vapour diffusion | Hanging drop | 7 chems | 6.0-6.0 | 4°C |
Retinal (11-cis)
pubchem
|
Inverse agonist | 2.8 | Inactive | 10.1126/SCIENCE.289.5480.739 | 2000-08-04 | ||
| 7TYW | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
calcitonin (salmon s...
pubchem
|
Agonist | 3.0 | Active | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | |
| 4S0V | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 9 chemicals | 9 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.9-6.0 | 20°C |
suvorexant
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Antagonist | 2.5 | Inactive | 10.1038/NATURE14035 | 2015-01-14 | |
| 6ZA8 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL508044
chembl_ligand
pubchem
|
Agonist (partial) | 2.7 | Intermediate | 10.1126/sciadv.abe5504 | 2021-02-10 | |
| 7WQ3 | GALR1 | GAL1 | Galanin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
galanin
gtoplig
chembl_ligand
gtoplig
pubchem
pubchem
pubchem
pubchem
pubchem
|
Agonist | 2.7 | Active | 2022-04-20 | ||
| 7VGZ | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ramelteon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.3 | Active | 2022-03-02 | ||
| 3OE6 | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20°C |
isothiourea-1t
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.2 | Inactive | 10.1126/SCIENCE.1194396 | 2010-10-27 | |
| 6PS1 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
timolol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Antagonist | 3.2 | Inactive | 10.1107/S2052252519013137 | 2019-11-13 | |
| 7MTS | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-glutamic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
2-methoxy-6-propyl-N... pubchem |
AgonistAgo-PAM | 3.2 | Active | 10.1038/S41586-021-03680-3 | 2021-07-07 | |
| 6ME5 | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
agomelatine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.2 | Inactive | 10.1038/S41586-019-1141-3 | 2019-04-24 | |
| 6ZFZ | ACM1 | M1 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3354065
chembl_ligand
pubchem
|
Agonist | 2.2 | Inactive | 10.1016/J.CELL.2021.11.001 | 2021-10-06 | |
| 7VL8 | CCR1 | CCR1 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1038/S41589-021-00918-Z | 2022-03-23 | |
| 7CFM | GPBAR | GPBA | Bile acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL2331646
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41586-020-2569-1 | 2020-09-09 | |
| 6LRY | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
sarafotoxin S6b
pubchem
gtoplig
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 3.0 | Inactive | 10.1016/J.BBRC.2019.12.091 | 2020-02-12 | |
| 6RZ4 | CLTR1 | CysLT1 | Leukotriene | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
pranlukast
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Antagonist | 2.7 | Intermediate | 10.1126/SCIADV.AAX2518 | 2019-10-30 | |
| 7WVY | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Amyloid beta-Peptide...
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41467-022-29361-X | 2022-04-13 | |
| 5OLH | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
vipadenant
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.6 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
| 4XNW | P2RY1 | P2Y1 | P2Y | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-8.0 | 20°C |
MRS2500
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.7 | Intermediate | 10.1038/NATURE14287 | 2015-04-01 | |
| 7S1M | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
exendin-4
pubchem
gtoplig
pubchem
|
Agonist | 2.4 | Active | 10.1038/S41589-021-00945-W | 2022-01-05 | |
| 7EJ0 | ADA2A | α2A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(-)-noradrenaline
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.2 | Active | 2022-04-13 | ||
| 7LLL | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
exendin-4
pubchem
gtoplig
pubchem
|
Agonist | 3.7 | Active | 10.1038/S41467-021-27760-0 | 2022-01-12 | |
| 7SBF | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-[(2S)-2-(dimethyla...
pubchem
|
Agonist | 2.9 | Active | 10.1002/ANIE.202200269 | 2022-04-20 | |
| 6LPJ | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.8 | Inactive | 10.1038/S41598-020-76277-X | 2020-11-25 | |
| 6IQL | DRD4 | D4 | Dopamine | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L745870
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.5 | Inactive | 10.7554/ELIFE.48822 | 2019-12-04 | |
| 7S3I | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
exendin-4
pubchem
gtoplig
pubchem
|
Agonist | 2.5 | Active | 10.1038/S41589-021-00945-W | 2022-01-05 | |
| 2YDV | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 4 chemicals | 4 steps | vapour diffusion | sitting drop | 5 chems | 6.4-6.4 | 4°C |
NECA
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 2.6 | Active | 10.1038/NATURE10136 | 2011-05-18 | ||
| 7EVZ | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
cenerimod
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.1 | Active | 10.1038/S41422-021-00566-X | 2021-09-29 | |
| 6BQG | 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
ergotamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.0 | Active | 10.1016/j.cell.2018.01.001 | 2018-02-14 | |
| 7VUI | GP139 | GPR139 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JNJ-63533054
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.3 | Active | 10.1038/S41422-021-00591-W | 2021-12-29 | |
| 7VAB | GIPR | GIP | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
tirzepatide
pubchem
gtoplig
|
Agonist | 3.2 | Active | 10.1038/S41467-022-28683-0 | 2022-03-02 | |
| 6PGS | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Geraniol
pubchem
|
unknown | 2.9 | Active | 2020-07-01 | ||
| 5OLZ | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
CHEMBL2024114
chembl_ligand
pubchem
|
Antagonist | 1.9 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
| 7WQ4 | GALR2 | GAL2 | Galanin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
galanin
gtoplig
chembl_ligand
gtoplig
pubchem
pubchem
pubchem
pubchem
pubchem
|
Agonist | 2.6 | Active | 2022-04-20 | ||
| 6WJC | ACM1 | M1 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ENDO-ATROPINE
chembl_ligand
pubchem
muscarinic toxin 7 gtoplig |
AntagonistNAM | 2.6 | Inactive | 10.1126/SCIENCE.AAX2517 | 2020-07-08 | |
| 2I37 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 2 chemicals | 2 steps | vapour diffusion | sitting drops | 5 chems | 7.0-8.0 | 5°C |
Apo (no ligand)
|
Apo (no ligand) | 4.2 | Inactive | 10.1073/PNAS.0608022103 | 2006-10-17 | ||
| 6Z8N | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2~{S})-4-methyl-2-[...
pubchem
|
Agonist | 2.8 | Intermediate | 10.1126/sciadv.abe5504 | 2021-02-10 | |
| 7SIN | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
NPS 2143
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 5.9 | Active | 10.1073/PNAS.2115849118 | 2022-01-19 | |
| 2YCZ | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | NA | 3 chems | 6.9-7.3 | NA |
Iodocyanopindolol
pubchem
|
Antagonist | 3.7 | Inactive | 10.1073/PNAS.1100185108 | 2011-06-01 | ||
| 5VAI | G1SGD4 | GLP-1 | Glucagon | B1 (Secretin) | Rabbit | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | Cryo-EM | FEI, glow-discharged holey carbon grids | 7 chems | 7.5-7.5 | 20°C |
CHEMBL410972
chembl_ligand
pubchem
pubchem
|
Agonist | 4.1 | Active | 10.1038/NATURE22394 | 2017-05-24 | ||
| 6FK9 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
(2~{S})-3-methyl-2-p...
pubchem
|
Agonist | 2.6 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
| 6OS2 | AGTR1 | AT1 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
TRV026
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.7 | Active | 10.1126/SCIENCE.AAY9813 | 2020-02-19 | |
| 6ZIN | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
meclinertant
pubchem
gtoplig
chembl_ligand
drugbank
|
Inverse agonist | 2.6 | Inactive | 10.1126/sciadv.abe5504 | 2021-02-10 | |
| 6PT0 | CNR2 | CB2 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
WIN55212-2
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2020.01.007 | 2020-02-12 | |
| 5TE3 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drop | 4 chems | 5.2-6.6 | 4°C |
B-Octylglucoside
pubchem
|
unknown | 2.7 | Active | 10.1073/PNAS.1617446114 | 2017-03-15 | ||
| 7RG9 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 10.1073/PNAS.2116506119 | 2022-04-13 | |
| 6KUY | ADA2A | α2A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2~{S})-4-fluoranyl-...
pubchem
|
Agonist (partial) | 3.2 | Inactive | 2019-12-04 | ||
| 6PRZ | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1160734
chembl_ligand
pubchem
|
Antagonist | 2.8 | Inactive | 10.1107/S2052252519013137 | 2019-11-13 | |
| 7D7M | PE2R4 | EP4 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PGE2
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
|
Agonist | 3.3 | Active | 2020-11-18 | ||
| 3OE0 | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
CVX15
|
Antagonist | 2.9 | Inactive | 10.1126/SCIENCE.1194396 | 2010-10-27 | |
| 3ODU | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20°C |
isothiourea-1t
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.5 | Inactive | 10.1126/SCIENCE.1194396 | 2010-10-27 | |
| 4UHR | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 4.8-4.8 | 22°C |
CGS 21680
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 2.6 | Active | 10.1124/mol.114.097360 | 2015-04-08 | |
| 6ME4 | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-iodo-melatonin
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.2 | Inactive | 10.1038/S41586-019-1141-3 | 2019-04-24 | |
| 6G79 | 5HT1B | 5-HT1B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | Cryo-EM | Volta phase plate, Falcon III detector (FEI Titan Krios, 300kV) | 5 chems | 7.5-7.5 | 4°C |
donitriptan
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.8 | Active | 10.1038/S41586-018-0241-9 | 2018-06-20 | ||
| 6B73 | OPRK | κ | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 6.5-7.0 | 20°C |
MP1104
pubchem
|
Agonist | 3.1 | Active | 10.1016/J.CELL.2017.12.011 | 2018-01-17 | |
| 5XPR | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C |
Apo (no ligand)
|
Apo (no ligand) | 3.6 | Inactive | 10.1038/NSMB.3450 | 2017-08-16 | |
| 7NA7 | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Ghrelin-27
|
Agonist | 2.7 | Active | 10.1038/S41467-021-26735-5 | 2021-12-15 | |
| 6LML | GLR | glucagon | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
glucagon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
pubchem
pubchem
pubchem
|
Agonist | 3.9 | Active | 10.1126/SCIENCE.AAZ5346 | 2020-04-01 | |
| 4MBS | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C |
maraviroc
pubchem
gtoplig
drugbank
chembl_ligand
gtoplig
|
Antagonist | 2.7 | Inactive | 10.1126/SCIENCE.1241475 | 2013-09-11 | |
| 7K15 | LT4R1 | BLT1 | Leukotriene | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-(tert-butylsulfony...
pubchem
|
Antagonist | 2.9 | Inactive | 2021-02-17 | ||
| 6Z10 | SUCR1 | succinate | Succinate | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4751488
chembl_ligand
pubchem
|
Antagonist | 2.3 | Intermediate | 10.1021/acs.jmedchem.0c01020 | 2020-09-16 | |
| 7TD1 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2r)-2-Hydroxy-3-(Ph...
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41467-022-28417-2 | 2022-02-09 | |
| 6N52 | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 4.0 | Inactive | 2019-01-23 | ||
| 6Z66 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Intermediate | 10.1126/sciadv.abe5504 | 2021-02-10 | |
| 7WF7 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
sphingosine 1-phosph...
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41589-021-00930-3 | 2022-01-05 | |
| 6DRX | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lisuride
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Antagonist | 3.1 | Intermediate | 10.1038/s41594-018-0116-7 | 2018-08-29 | |
| 7VUZ | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PAMP-12
pubchem
|
Agonist | 2.9 | Active | 2021-12-01 | ||
| 6KPF | CNR2 | CB2 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AM841
pubchem
gtoplig
|
Agonist | 2.9 | Active | 10.1016/J.CELL.2020.01.008 | 2020-02-12 | |
| 4QIN | SMO | SMO | Frizzled | F (Frizzled) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 6 chems | 7.2-7.2 | 20°C |
SAG1.5
pubchem
|
Agonist | 2.6 | Inactive | 10.1038/NCOMMS5355 | 2014-07-23 | |
| 7CKY | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3697578
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | |
| 4U14 | ACM3 | M3 | Acetylcholine (muscarinic) | A (Rhodopsin) | Rat | Baculovirus | Sf9 | Insect | 9 chemicals | 9 steps | sponge mesophase | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 8.1-8.1 | 298 K |
tiotropium
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
|
Antagonist | 3.6 | Inactive | 10.1016/J.STR.2014.08.022 | 2014-11-26 | |
| 5ZKQ | PTAFR | PAF | Platelet-activating factor | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ABT-491
pubchem
gtoplig
chembl_ligand
|
Inverse agonist | 2.9 | Intermediate | 10.1038/S41594-018-0068-Y | 2018-06-20 | |
| 4Z36 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.5-5.5 | 20°C |
ONO-3080573
pubchem
gtoplig
|
Antagonist | 2.9 | Inactive | 10.1016/J.CELL.2015.06.002 | 2015-06-03 | |
| 4IB4 | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 8.0-8.5 | 20°C |
ergotamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.7 | Intermediate | 10.1126/science.1232808 | 2013-03-13 | |
| 7TZF | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
amylin peptide
|
Agonist | 2.4 | Active | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | |
| 6LW5 | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL552527
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-020-15009-1 | 2020-03-25 | |
| 6C1Q | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.5-6.5 | 10°C |
NDT9513727
pubchem
gtoplig
chembl_ligand
PMX53 pubchem gtoplig chembl_ligand |
NAMAntagonist | 2.9 | Inactive | 10.1038/S41594-018-0067-Z | 2018-05-30 | |
| 6QZH | CCR7 | CCR7 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SCHEMBL13407377
pubchem
|
Allosteric antagonist | 2.1 | Inactive | 10.1016/J.CELL.2019.07.028 | 2019-09-04 | |
| 7CA3 | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
BHFF
pubchem
|
PAM | 4.5 | Active | 10.1016/J.JMB.2020.09.023 | 2020-11-11 | |
| 6H7O | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(S)-Cyanopindolol
pubchem
|
Agonist | 2.8 | Active | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | |
| 7DGD | GRM1 | mGlu1 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 4.0 | Inactive | 10.1007/S13238-020-00808-5 | 2021-09-22 | |
| 4BWB | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | NA | E. coli BL21(DE3) | Bacteria | 3 chemicals | 3 steps | vapour diffusion | sitting drops | 7 chems | 5.5-5.5 | 4°C |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 3.6 | Inactive | 10.1073/PNAS.1317903111 | 2014-01-29 | ||
| 7DTY | GIPR | GIP | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
GIP
pubchem
pubchem
|
Agonist | 3.0 | Active | 10.7554/ELIFE.68719 | 2021-08-04 | |
| 5X93 | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C |
K-8794
pubchem
gtoplig
|
Antagonist | 2.2 | Inactive | 10.1038/NSMB.3450 | 2017-08-16 | |
| 7CRH | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1416789
chembl_ligand
pubchem
|
Agonist | 3.3 | Active | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | |
| 5XSZ | Q08BG4 | LPA6 | Lysophospholipid (LPA) | A (Rhodopsin) | Zebrafish | Baculovirus | Sf9 | Insect | 8 chemicals | 8 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 6 chems | 6.0-6.0 | 20°C |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Intermediate | 10.1038/NATURE23448 | 2017-08-16 | |
| 5X7D | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 3 chemicals | 3 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 7.5-7.5 | 20°C |
Carazolol
pubchem
4-carbamoyl-N-[(2R)-... pubchem |
AntagonistAllosteric antagonist | 2.7 | Inactive | 10.1038/NATURE23652 | 2017-08-16 | |
| 6LPL | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.0 | Inactive | 10.1038/S41598-020-76277-X | 2020-11-25 | |
| 7PIU | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
setmelanotide
pubchem
gtoplig
drug_central
chembl_ligand
drugbank
|
Agonist | 2.6 | Active | 10.1038/S41422-021-00569-8 | 2021-11-17 | |
| 6GPX | CCR2 | CCR2 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MK-0812
pubchem
|
Antagonist | 2.7 | Inactive | 10.1016/J.STR.2018.10.027 | 2019-01-02 | |
| 5NM2 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.0 | Inactive | 10.1038/S41467-017-00630-4 | 2017-09-27 | |
| 7VV0 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PAMP-12
pubchem
|
Agonist | 3.5 | Active | 2021-12-01 | ||
| 7LJC | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY3154207
pubchem
gtoplig
chembl_ligand
CHEMBL1160787 chembl_ligand pubchem |
PAMAgonist | 3.0 | Active | 10.1101/2021.02.07.430101 | 2021-03-03 | |
| 4Z34 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.5-5.5 | 20°C |
ONO-9780307
pubchem
gtoplig
|
Antagonist | 3.0 | Inactive | 10.1016/J.CELL.2015.06.002 | 2015-06-03 | |
| 6UUN | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Adrenomedullin
pubchem
|
Agonist | 3.0 | Active | 10.1021/ACSPTSCI.9B00080 | 2020-03-25 | |
| 5ZHP | ACM3 | M3 | Acetylcholine (muscarinic) | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(1R,2R,4S,5S,7s)-7-(...
pubchem
|
Antagonist | 3.1 | Inactive | 10.1073/PNAS.1813988115 | 2018-11-28 | |
| 7VDM | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 3.0 | Active | 2021-12-01 | ||
| 7EJK | ADA2A | α2A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
oxymetazoline
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.4 | Active | 2022-04-13 | ||
| 4PXF | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 3 chems | 6.0-6.0 | 4°C |
B-Octylglucoside
pubchem
|
unknown | 2.8 | Active | 10.1038/NCOMMS5801 | 2014-09-17 | ||
| 6N4B | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
MDMB-Fubinaca
pubchem
gtoplig
|
Agonist | 3.0 | Active | 10.1016/J.CELL.2018.11.040 | 2019-01-30 | |
| 7DD6 | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcium
pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem |
AgonistPAM | 3.2 | Active | 10.1126/SCIADV.ABG1483 | 2021-06-16 | |
| 5VEW | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.2-6.6 | 20°C |
PF-06372222
pubchem
|
NAM | 2.7 | Inactive | 10.1038/NATURE22378 | 2017-05-24 | |
| 2Z73 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Japanese flying squid | NA | Native | Squid | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 5 chems | 6.4-6.4 | 4°C |
Retinal (11-cis)
pubchem
|
Inverse agonist | 2.5 | Inactive | 10.1038/NATURE06925 | 2008-05-13 | ||
| 7RM5 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.8 | Inactive | 10.1073/PNAS.2106041118 | 2021-09-08 | |
| 5UEN | AA1R | A1 | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-8.0 | 20°C |
DU172
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.2 | Inactive | 10.1016/j.cell.2017.01.042 | 2017-03-01 | |
| 6WWZ | CCR6 | CCR6 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCL20
gtoplig
|
Agonist | 3.3 | Active | 10.1038/S41467-020-16820-6 | 2020-06-24 | |
| 7TD3 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
sphingosine 1-phosph...
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41467-022-28417-2 | 2022-02-09 | |
| 7CZ5 | GHRHR | GHRH | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Somatoliberin
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41467-020-18945-0 | 2020-11-18 | |
| 6ME3 | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-phenylmelatonin
pubchem
|
Agonist | 2.9 | Inactive | 10.1038/S41586-019-1141-3 | 2019-04-24 | |
| 7C6A | AGTR2 | AT2 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL404594
chembl_ligand
pubchem
|
Agonist | 3.4 | Active | 2020-07-29 | ||
| 5CGD | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-6.8 | 20°C |
CHEMBL3603923
chembl_ligand
pubchem
|
NAM | 2.6 | Inactive | 10.1021/acs.jmedchem.5b00892 | 2015-08-12 | |
| 3D4S | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C |
timolol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Inverse agonist | 2.8 | Inactive | 10.1016/J.STR.2008.05.001 | 2008-06-17 | |
| 7WVX | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
humanin
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-022-29361-X | 2022-04-13 | |
| 6P9Y | PACR | PAC1 | VIP and PACAP | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL524658
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.MOLCEL.2020.01.012 | 2020-02-05 | |
| 7WC8 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LUMATEPERONE
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 2.5 | Inactive | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | |
| 3C9L | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | NA | NA | 1 chemicals | 1 steps | NA | NA | NA | 1 chems | 0.0-0.0 | NA |
Retinal (11-cis)
pubchem
|
Inverse agonist | 2.7 | Inactive | 10.1107/S0907444908017162 | 2008-08-05 | |
| 7M3G | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcium
pubchem
evocalcet pubchem gtoplig drug_central chembl_ligand drugbank L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem |
AgonistPAMPAM | 2.5 | Active | 10.1038/S41586-021-03691-0 | 2021-06-30 | |
| 3PWH | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 6 chems | 8.0-8.8 | 4°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 3.3 | Inactive | 10.1016/J.STR.2011.06.014 | 2011-09-07 | ||
| 7S8P | MRGX4 | MRGPRX4 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-[(1r,3R,5S,7R)-3,5...
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41586-021-04126-6 | 2021-11-17 | |
| 7F16 | PTH2R | PTH2 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
TIP39
gtoplig
|
Agonist | 2.8 | Active | 10.1073/PNAS.2101279118 | 2021-08-18 | |
| 6D27 | PD2R2 | DP2 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL179036
chembl_ligand
pubchem
|
Antagonist | 2.7 | Inactive | 10.1016/J.MOLCEL.2018.08.009 | 2018-10-03 | |
| 6J21 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
aprepitant
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 3.2 | Inactive | 10.1038/S41467-019-08568-5 | 2019-03-06 | |
| 7JVQ | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
apomorphine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.0 | Active | 10.1016/J.CELL.2021.01.027 | 2021-02-24 | |
| 6HLP | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
netupitant
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Antagonist | 2.2 | Inactive | 10.1038/S41467-018-07939-8 | 2019-01-16 | |
| 4XEE | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-8.0 | 20°C |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 2.9 | Active | 10.1038/NCOMMS8895 | 2015-07-29 | |
| 5NLX | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.1 | Inactive | 10.1038/S41467-017-00630-4 | 2017-09-27 | |
| 7P00 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 2.7 | Active | 10.1126/SCIADV.ABK2872 | 2021-12-15 | |
| 7NA8 | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ibutamoren
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.7 | Active | 10.1038/S41467-021-26735-5 | 2021-12-15 | |
| 6OMM | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL552527
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41467-020-14728-9 | 2020-02-26 | |
| 3UON | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.5-7.5 | 19.85°C |
CHEMBL558910
chembl_ligand
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/NATURE10753 | 2012-02-01 | |
| 7WIH | GRM3 | mGlu3 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4081453
chembl_ligand
pubchem
|
Agonist | 3.7 | Inactive | 10.1038/S41422-022-00623-Z | 2022-03-16 | |
| 7TD2 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2r)-2-Hydroxy-3-(Ph...
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41467-022-28417-2 | 2022-02-09 | |
| 6C1R | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.5-6.5 | 10°C |
PMX53
pubchem
gtoplig
chembl_ligand
avacopan pubchem gtoplig chembl_ligand drugbank |
AntagonistNAM | 2.2 | Inactive | 10.1038/S41594-018-0067-Z | 2018-05-30 | |
| 7E32 | 5HT1D | 5-HT1D | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-hydroxytryptamine
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.9 | Active | 10.1038/S41586-021-03376-8 | 2021-04-21 | |
| 4BVN | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 7.0-7.0 | 22°C |
(S)-Cyanopindolol
pubchem
|
Antagonist | 2.1 | Inactive | 10.1371/JOURNAL.PONE.0092727 | 2014-04-02 | |
| 6PB1 | CRFR2 | CRF2 | Corticotropin-releasing factor | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL427807
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1016/J.MOLCEL.2020.01.013 | 2020-02-12 | |
| 5XRA | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | Transient_transfection | HEK293T | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.4-6.4 | 20°C |
AM11542
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.8 | Active | 10.1038/NATURE23272 | 2017-07-12 | |
| 2HPY | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 5.9-6.1 | 283 K |
Retinal (all-trans)
pubchem
|
Agonist | 2.8 | Inactive | 10.1073/PNAS.0601765103 | 2006-08-22 | ||
| 6TP3 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
daridorexant
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 3.0 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
| 7FIN | GIPR | GIP | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Peptide-20
|
Agonist | 3.1 | Active | 10.1038/S41467-022-28683-0 | 2022-02-23 | |
| 6LI3 | GPR52 | GPR52 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.3 | Active | 10.1038/S41586-020-2019-0 | 2020-02-26 | |
| 6H7M | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
levosalbutamol
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 2.8 | Active | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | |
| 6X18 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL410972
chembl_ligand
pubchem
pubchem
|
Agonist | 2.1 | Active | 10.1101/2020.08.16.252585 | 2020-09-09 | |
| 6E3Y | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcitonin gene-rela...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-018-0535-Y | 2018-09-19 | |
| 7TYL | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
amylin peptide
|
Agonist | 3.3 | Active | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | |
| 5ZBH | NPY1R | Y1 | Neuropeptide Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
BMS-193885
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/S41586-018-0046-X | 2018-04-25 | |
| 4IAR | 5HT1B | 5-HT1B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.5-7.5 | 20°C |
ergotamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.7 | Inactive | 10.1126/SCIENCE.1232807 | 2013-03-13 | |
| 6DS0 | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY266097
pubchem
|
Antagonist | 3.2 | Intermediate | 10.1038/s41594-018-0116-7 | 2018-08-29 | |
| 5CXV | ACM1 | M1 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 8.0-8.0 | 20°C |
0HK
pubchem
|
Antagonist | 2.7 | Inactive | 10.1038/NATURE17188 | 2016-03-09 | |
| 5V56 | SMO | SMO | Frizzled | F (Frizzled) | Human | Transient_transfection | HEK293F | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
N-methyl-N-[1-[4-(2-...
pubchem
|
Antagonist | 2.9 | Inactive | 10.1038/NCOMMS15383 | 2017-05-24 | |
| 7EWR | GP158 | GPR158 | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 4.7 | Inactive | 10.1038/S41467-021-27147-1 | 2021-12-01 | |
| 5T1A | CCR2 | CCR2 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 6.5-6.5 | 20 °C. |
CCR2-RA-[R]
pubchem
gtoplig
chembl_ligand
BMS-681 pubchem gtoplig chembl_ligand |
Allosteric antagonistAntagonist | 2.8 | Inactive | 10.1038/NATURE20605 | 2016-12-14 | |
| 6V9S | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JH112
pubchem
gtoplig
|
Antagonist | 3.5 | Inactive | 10.1073/PNAS.2002704117 | 2020-07-15 | |
| 7F1R | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCL5
gtoplig
|
Agonist | 3.0 | Active | 10.1038/S41467-021-24438-5 | 2021-07-14 | |
| 7M3J | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
NPS 2143
pubchem
gtoplig
chembl_ligand
drugbank
|
NAM | 4.1 | Inactive | 10.1038/S41586-021-03691-0 | 2021-06-30 | |
| 6NI3 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
BI-167107
pubchem
|
Agonist | 3.8 | Active | 10.1038/S41594-019-0330-Y | 2019-11-20 | |
| 7TUZ | GP183 | GPR183 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2S,4aS,4bS,7R,8S,8a...
pubchem
|
Agonist | 3.1 | Active | 10.1016/J.STR.2022.04.006 | 2022-04-13 | |
| 7TYI | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Amylin rat
pubchem
|
Agonist | 3.3 | Active | 10.1126/SCIENCE.ABM9609 | 2022-03-30 | |
| 7DHI | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
levosalbutamol
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 3.3 | Active | 10.1093/NSR/NWAA284 | 2020-12-16 | |
| 7E2X | 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.0 | Active | 10.1038/S41586-021-03376-8 | 2021-04-14 | |
| 6PT2 | OPRD | δ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
KGCHM07
|
Agonist | 2.8 | Active | 10.1126/SCIADV.AAX9115 | 2019-12-11 | |
| 7EPD | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.9 | Inactive | 10.1038/S41586-021-03641-W | 2021-06-23 | |
| 7WU5 | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.0 | Active | 10.1038/S41586-022-04580-W | 2022-04-27 | |
| 5UVI | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 3.2 | Inactive | 10.1107/S205225251700570X | 2017-05-24 | |
| 5XJM | AGTR2 | AT2 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL404594
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41594-018-0079-8 | 2018-07-11 | |
| 7SHE | GP158 | GPR158 | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.4 | Inactive | 10.1126/SCIENCE.ABL4732 | 2021-12-01 | |
| 6KJV | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PF-06372222
pubchem
|
NAM | 2.8 | Inactive | 10.1107/S2052252519013496 | 2019-11-13 | |
| 6PS3 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3799125
chembl_ligand
pubchem
|
Antagonist | 2.5 | Inactive | 10.1107/S2052252519013137 | 2019-11-13 | |
| 7KI0 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
semaglutide
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
|
Agonist | 2.5 | Active | 10.1016/J.CELREP.2021.109374 | 2021-08-04 | |
| 3NYA | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 21-23°C |
CHEMBL1160734
chembl_ligand
pubchem
|
Antagonist | 3.2 | Inactive | 10.1021/JA105108Q | 2010-08-11 | |
| 7DTU | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-tryptophan
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
PAM | 4.4 | Inactive | 10.1038/S41422-021-00474-0 | 2021-03-10 | |
| 7T6T | FPR1 | FPR1 | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
synthetic peptide
|
Agonist | 3.2 | Active | 2022-03-30 | ||
| 3PQR | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 3 chems | 5.6-5.6 | 4°C |
Retinal (all-trans)
pubchem
|
Agonist | 2.9 | Active | 10.1038/NATURE09789 | 2011-03-09 | ||
| 7UM5 | 5HT5A | 5-HT5A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-CT
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.7 | Active | 10.1038/S41594-022-00796-6 | 2022-07-20 | |
| 7S8O | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(R)-ZINC-3573
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.6 | Active | 10.1038/S41586-021-04126-6 | 2021-11-17 | |
| 7SIL | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cyclomethyltryptopha...
pubchem
tecalcet pubchem gtoplig chembl_ligand |
AgonistAgonist | 2.7 | Active | 10.1073/PNAS.2115849118 | 2022-01-19 | |
| 6KQI | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CP55940
pubchem
gtoplig
chembl_ligand
gtoplig
Org27569 pubchem gtoplig chembl_ligand |
AgonistNAM | 3.3 | Inactive | 10.1038/S41589-019-0387-2 | 2019-10-23 | |
| 7BZ2 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
arformoterol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.8 | Active | 10.1038/S41421-020-0176-9 | 2020-08-05 | |
| 7M8W | PD2R2 | DP2 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
15(<i>R</i>)-15-meth...
pubchem
gtoplig
|
Antagonist | 2.6 | Inactive | 10.1073/PNAS.2102813118 | 2021-08-25 | |
| 7F8X | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
NN9056
|
Agonist | 3.0 | Inactive | 10.1038/S41589-021-00866-8 | 2021-12-29 | |
| 6MET | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Envelope glycoprotei...
|
Antagonist | 4.5 | Inactive | 10.1038/S41586-018-0804-9 | 2018-12-12 | |
| 5OLG | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.9 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
| 5G53 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | vapour diffusion | Sitting drop | 6 chems | 5.7-5.7 | 4°C |
NECA
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 3.4 | Active | 10.1038/NATURE18966 | 2016-08-03 | ||
| 4A4M | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Stable_cells | HEK293T | Mammalian | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 3 chems | 4.5-4.5 | 4°C |
Retinal (all-trans)
pubchem
|
Agonist | 3.3 | Active | 10.1073/PNAS.1114089108 | 2012-01-25 | ||
| 7V9M | GHRHR | GHRH | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Somatoliberin
pubchem
|
Agonist | 3.3 | Active | 2021-10-20 | ||
| 7RKN | US28 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Fractalkine
pubchem
|
Agonist | 3.6 | Active | 10.1126/SCIADV.ABL5442 | 2022-01-26 | |
| 6A94 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
zotepine
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Antagonist | 2.9 | Inactive | 10.1038/S41594-018-0180-Z | 2019-02-13 | |
| 4OO9 | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 6.8-6.8 | 20°C |
MAVOGLURANT
chembl_ligand
pubchem
|
NAM | 2.6 | Inactive | 10.1038/NATURE13396 | 2014-07-02 | |
| 7BB6 | V2R | V2 | Vasopressin and oxytocin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
vasopressin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 4.2 | Active | 10.1126/SCIADV.ABG5628 | 2021-06-02 | |
| 7F4H | MSHR | MC1 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL407070
chembl_ligand
pubchem
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41422-021-00557-Y | 2021-09-08 | |
| 4O9R | SMO | SMO | Frizzled | F (Frizzled) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 7.4-7.4 | 20°C |
cyclopamine
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.2 | Inactive | 10.1038/NCOMMS4309 | 2014-03-05 | |
| 6LMK | GLR | glucagon | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
glucagon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
pubchem
pubchem
pubchem
|
Agonist | 3.7 | Active | 10.1126/SCIENCE.AAZ5346 | 2020-04-01 | |
| 7WC7 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lisuride
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.6 | Inactive | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | |
| 6RZ8 | CLTR2 | CysLT2 | Leukotriene | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ONO-2080365
pubchem
|
Antagonist | 2.7 | Intermediate | 10.1038/S41467-019-13348-2 | 2019-12-11 | |
| 6N48 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-[[(3R)-4-(4-Tert-b...
pubchem
BI-167107 pubchem |
PAMAgonist | 3.2 | Active | 10.1126/SCIENCE.AAW8981 | 2019-06-26 | |
| 5EE7 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | Transient_transfection | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-6.5 | 20°C |
MK-0893
pubchem
gtoplig
chembl_ligand
drugbank
Octaethylene glycol ... pubchem |
NAMAntagonist | 2.5 | Inactive | 10.1038/NATURE17414 | 2016-04-20 | |
| 7VDL | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cortistatin 14
pubchem
|
Agonist | 3.2 | Active | 2021-12-01 | ||
| 5IU7 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
2-(Furan-2-yl)-5-N-[...
pubchem
|
Antagonist | 1.9 | Inactive | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | |
| 7MTA | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (all-trans)
pubchem
|
Agonist | 4.1 | Active | 10.1038/S41586-021-03721-X | 2021-07-07 | |
| 7WI8 | GRM3 | mGlu3 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 4.2 | Inactive | 10.1038/S41422-022-00623-Z | 2022-03-16 | |
| 6FKB | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
2-(4-Chlorophenyl)-1...
pubchem
|
Agonist | 3.0 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
| 7EWP | GP158 | GPR158 | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 4.3 | Inactive | 10.1038/S41467-021-27147-1 | 2021-12-01 | |
| 6LI1 | GPR52 | GPR52 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Inactive | 10.1038/S41586-020-2019-0 | 2020-02-26 | |
| 6LFM | CXCR2 | CXCR2 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Interleukin-8
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-020-2492-5 | 2020-09-02 | |
| 5K2A | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.5 | Inactive | 10.1126/SCIADV.1600292 | 2016-09-21 | |
| 7TYX | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
amylin peptide
|
Agonist | 2.6 | Active | 10.1126/SCIENCE.ABM9609 | 2022-03-30 | |
| 2YDO | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 4 chemicals | 4 steps | vapour diffusion | sitting drop | 5 chems | 7.6-7.6 | 4°C |
adenosine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.0 | Active | 10.1038/NATURE10136 | 2011-05-18 | ||
| 7DW9 | V2R | V2 | Vasopressin and oxytocin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
vasopressin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.6 | Active | 10.1038/S41422-021-00480-2 | 2021-07-21 | |
| 4XES | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.4 | 20°C |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 2.6 | Active | 10.1038/NCOMMS8895 | 2015-07-29 | |
| 6FK8 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
(2~{R},3~{S})-3-azan...
pubchem
|
Agonist | 2.9 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
| 5DGY | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Human | Transient_transfection | HEK293S | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monopalmitolein (9.7 MAG) | 5 chems | 5.0-5.0 | 20°C |
Apo (no ligand)
|
Apo (no ligand) | 7.7 | Active | 10.1038/SDATA.2016.21 | 2016-03-23 | |
| 5OLV | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
CHEMBL1671936
chembl_ligand
pubchem
|
Antagonist | 2.0 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
| 7RKM | US28 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Fractalkine
pubchem
|
Agonist | 3.5 | Active | 10.1126/SCIADV.ABL5442 | 2022-01-26 | |
| 6PB0 | CRFR1 | CRF1 | Corticotropin-releasing factor | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL427807
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.MOLCEL.2020.01.013 | 2020-02-12 | |
| 5VEX | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.8 | 20°C |
NNC0640
pubchem
gtoplig
|
NAM | 3.0 | Inactive | 10.1038/NATURE22378 | 2017-05-17 | |
| 4YAY | AGTR1 | AT1 | Angiotensin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 6 chems | 5.0-6.0 | 20°C |
ZD-7155
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.9 | Inactive | 10.1016/J.CELL.2015.04.011 | 2015-04-22 | |
| 6K42 | ADA2B | α2B | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dexmedetomidine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 4.1 | Active | 10.1038/S41589-020-0492-2 | 2020-04-15 | |
| 7CX2 | PE2R2 | EP2 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PGE2
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
|
Agonist | 2.8 | Active | 10.1126/SCIADV.ABF1268 | 2021-05-05 | |
| 6UO8 | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
GS39783
pubchem
gtoplig
chembl_ligand
CHEMBL112710 chembl_ligand pubchem pubchem |
PAMAgonist | 3.6 | Active | 10.1038/S41586-020-2408-4 | 2020-06-10 | |
| 7KI1 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Taspoglutide
pubchem
|
Agonist | 2.5 | Active | 10.1016/J.CELREP.2021.109374 | 2021-08-04 | |
| 6OT0 | SMO | SMO | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
24,25-Epoxy-choleste...
pubchem
|
Agonist | 3.9 | Active | 10.1038/S41586-019-1286-0 | 2019-06-12 | |
| 7L0R | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 4.2 | Active | 2021-01-06 | ||
| 6PH7 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Nerol
pubchem
|
unknown | 2.9 | Active | 2020-07-01 | ||
| 7AUE | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
setmelanotide
pubchem
gtoplig
drug_central
chembl_ligand
drugbank
|
Agonist | 3.0 | Active | 10.1126/SCIENCE.ABF7958 | 2021-04-28 | |
| 6OBA | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AS408
pubchem
gtoplig
CHEMBL1160734 chembl_ligand pubchem |
NAMAntagonist | 3.1 | Inactive | 10.1038/S41589-020-0549-2 | 2020-03-25 | |
| 5V57 | SMO | SMO | Frizzled | F (Frizzled) | Human | Transient_transfection | HEK293F | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
N-methyl-N-[1-[4-(2-...
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/NCOMMS15383 | 2017-05-24 | |
| 3NY9 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.5-8.0 | 20°C |
CHEMBL1233771
chembl_ligand
pubchem
|
Inverse agonist | 2.8 | Inactive | 10.1021/JA105108Q | 2010-08-11 | |
| 7BU7 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
BI-167107
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41422-020-00424-2 | 2020-12-02 | |
| 5F8U | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 1 chems | 3.6-4.0 | 18°C |
(S)-Cyanopindolol
pubchem
|
Antagonist | 3.4 | Inactive | 10.1038/NSMB.3130 | 2015-12-23 | ||
| 5TZY | FFAR1 | FFA1 | Free fatty acid | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.3-6.8 | 20°C |
(2S,3R)-3-Cyclopropy...
pubchem
MK-8666 pubchem |
PAMAgonist | 3.2 | Intermediate | 10.1038/NSMB.3417 | 2017-06-07 | |
| 6WPW | GLR | glucagon | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Glucagon derivative ...
|
Agonist | 3.1 | Active | 10.1126/SCIENCE.ABA3373 | 2020-08-12 | |
| 4BUO | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | NA | E. coli BL21(DE3) | Bacteria | 6 chemicals | 6 steps | vapour diffusion | Sitting drop | 5 chems | 9.4-9.4 | 4°C |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 2.8 | Inactive | 10.1073/PNAS.1317903111 | 2014-01-29 | ||
| 4EIY | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.8 | Inactive | 10.1126/SCIENCE.1219218 | 2012-07-25 | |
| 7EPB | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
eglumegad
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 3.1 | Inactive | 10.1038/S41586-021-03641-W | 2021-06-23 | |
| 5IU4 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20 |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.7 | Inactive | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | |
| 7FIY | GIPR | GIP | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
tirzepatide
pubchem
gtoplig
|
Agonist | 3.4 | Active | 10.1038/S41467-022-28683-0 | 2022-03-02 | |
| 5UIG | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | vapour diffusion | Sitting drop | 6 chems | 7.0-7.0 | 20°C |
5-Amino-N-[(2-Methox...
pubchem
|
Antagonist | 3.5 | Inactive | 10.1073/PNAS.1621423114 | 2017-02-08 | ||
| 7RTB | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Peptide-19
|
Agonist | 2.1 | Active | 10.1016/J.BBRC.2021.09.016 | 2021-10-06 | |
| 6UOA | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL112710
chembl_ligand
pubchem
pubchem
|
Agonist | 6.3 | Inactive | 10.1038/S41586-020-2408-4 | 2020-06-10 | |
| 5UNG | AGTR2 | AT2 | Angiotensin | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 8.0-8.0 | 20°C |
compound 1 [PMID: 28...
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.8 | Active | 10.1038/NATURE22035 | 2017-04-05 | |
| 7CMU | DRD3 | D3 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
pramipexole
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.0 | Active | 10.1016/J.MOLCEL.2021.01.003 | 2021-03-10 | |
| 5ZK3 | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL558910
chembl_ligand
pubchem
|
Antagonist | 2.6 | Inactive | 10.1038/S41589-018-0152-Y | 2018-11-21 | |
| 6AQF | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Pichia Pastoris | P. pastoris SMD1163 | Yeast | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.5 | Inactive | 10.1016/J.CELL.2017.12.004 | 2018-01-10 | |
| 4BV0 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | NA | E. coli BL21(DE3) | Bacteria | 3 chemicals | 3 steps | vapour diffusion | sitting drops | 5 chems | 9.4-9.4 | 4°C |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 3.1 | Inactive | 10.1073/PNAS.1317903111 | 2014-01-29 | ||
| 5WB2 | Q80KM9 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 6.0-6.0 | 16-20°C |
CX3CL1
gtoplig
|
Agonist | 3.5 | Active | 10.7554/ELIFE.35850 | 2018-06-13 | |
| 6OS9 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JMV449
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.0 | Active | 10.1038/S41586-019-1337-6 | 2019-07-10 | |
| 7F1S | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 10.1038/S41467-021-24438-5 | 2021-07-14 | |
| 4PHU | FFAR1 | FFA1 | Free fatty acid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.6-7.6 | 20°C |
fasiglifam
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.3 | Intermediate | 10.1038/NATURE13494 | 2014-07-16 | |
| 5VRA | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 4.6-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.4 | Inactive | 10.1038/NPROT.2017.135 | 2017-12-13 | |
| 6H7J | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LEVISOPRENALINE
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | |
| 7DTV | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcium
pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem |
AgonistPAM | 3.5 | Inactive | 10.1038/S41422-021-00474-0 | 2021-03-10 | |
| 7WUJ | AGRG4 | ADGRG4 | ADGRG | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.3 | Active | 10.1038/S41586-022-04590-8 | 2022-04-27 | |
| 6VMS | DRD2 | D2 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
bromocriptine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.8 | Active | 10.1038/S41586-020-2379-5 | 2020-06-17 | |
| 6LUQ | DRD2 | D2 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
haloperidol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Antagonist | 3.1 | Inactive | 10.1038/S41467-020-14884-Y | 2020-03-04 | |
| 7LLY | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Pro-glucagon
pubchem
|
Agonist | 3.3 | Active | 2022-01-12 | ||
| 5UZ7 | CALCR | CT | Calcitonin | B1 (Secretin) | Human | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | Cryo-EM | Volta phase plate (FEI) | 6 chems | 7.4-7.4 | cryoTemp(liquid Nitrogen) | N/A | N/A | 4.1 | Active | 10.1038/NATURE22327 | 2017-05-03 | ||
| 7F54 | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
afamelanotide
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
pubchem
pubchem
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41422-021-00552-3 | 2021-11-03 | |
| 7EWL | GP158 | GPR158 | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.5 | Inactive | 10.1038/S41467-021-27147-1 | 2021-12-01 | |
| 6A93 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
risperidone
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Antagonist | 3.0 | Inactive | 10.1038/S41594-018-0180-Z | 2019-02-13 | |
| 6PS2 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1160734
chembl_ligand
pubchem
|
Antagonist | 2.4 | Inactive | 10.1107/S2052252519013137 | 2019-11-13 | |
| 4DKL | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | Baculovirus | Sf9 | Insect | 12 chemicals | 12 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C |
Methyl 4-[[(4R,4aS,7...
pubchem
|
Antagonist | 2.8 | Inactive | 10.1038/NATURE10954 | 2012-03-21 | |
| 7DB6 | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ramelteon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.3 | Active | 10.1038/S41594-021-00634-1 | 2021-08-18 | |
| 6P9X | CRFR1 | CRF1 | Corticotropin-releasing factor | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Corticoliberin
pubchem
|
Agonist | 2.9 | Active | 10.1016/J.MOLCEL.2020.01.012 | 2020-02-05 | |
| 7DD5 | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-tryptophan
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
NPS 2143 pubchem gtoplig chembl_ligand drugbank Calcium pubchem |
PAMNAMAgonist | 3.2 | Inactive | 10.1126/SCIADV.ABG1483 | 2021-06-16 | |
| 6LFO | CXCR2 | CXCR2 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Interleukin-8
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41586-020-2492-5 | 2020-09-02 | |
| 6XBJ | SMO | SMO | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cholesterol
pubchem
|
Agonist | 3.9 | Active | 10.1038/S41589-020-0646-2 | 2020-09-30 | |
| 6O3C | SMO | SMO | Frizzled | F (Frizzled) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SAG21k
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41586-019-1355-4 | 2019-07-03 | |
| 7VV5 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 48/80
pubchem
gtoplig
|
Agonist | 2.8 | Active | 2021-12-01 | ||
| 6D35 | Q98SW5 | SMO | Frizzled | F (Frizzled) | African clawed frog | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.5 | 20°C |
Cholesterol
pubchem
|
Agonist | 3.9 | Active | 10.1016/J.CELL.2018.04.029 | 2018-05-23 | |
| 6HLO | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
aprepitant
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 2.4 | Inactive | 10.1038/S41467-018-07939-8 | 2019-01-16 | |
| 6WH4 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL428892
chembl_ligand
pubchem
|
Inverse agonist | 3.4 | Inactive | 10.1016/J.CELL.2020.08.024 | 2020-09-23 | |
| 7FIG | LSHR | LH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Choriogonadotropin b...
gtoplig
Glycoprotein alpha gtoplig |
AgonistAgonist | 3.9 | Active | 10.1038/S41586-021-03924-2 | 2021-09-29 | |
| 4JKV | SMO | SMO | Frizzled | F (Frizzled) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 6 chems | 7.4-7.4 | 20°C |
taladegib
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.5 | Inactive | 10.1038/NATURE12167 | 2013-04-24 | |
| 6CM4 | DRD2 | D2 | Dopamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 6 chems | 7.8-7.8 | 20°C |
risperidone
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Inverse agonist | 2.9 | Inactive | 10.1038/NATURE25758 | 2018-03-14 | |
| 6RZ5 | CLTR1 | CysLT1 | Leukotriene | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
zafirlukast
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Antagonist | 2.5 | Intermediate | 10.1126/SCIADV.AAX2518 | 2019-10-30 | |
| 6MXT | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
salmeterol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.0 | Active | 10.1038/s41589-018-0145-x | 2018-11-14 | |
| 7U2L | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-(5-carbamimidamido...
|
Agonist | 3.2 | Active | 2022-05-04 | ||
| 5O9H | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | |||||||||||||