Experiment Browser
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RECEPTOR | EXPRESSION | SOLUBILIZATION | PURIFICATION | STRUCTURE DETERMINATION | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PDB | pH | Temp | Resolution | Reference | Date | ||||||||||||||||||
7UL3 | HRH2 | H2 | Histamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
famotidine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
|
Antagonist | 3.0 | Inactive | 2022-06-29 | ||
7L0S | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 4.5 | Active | 2021-01-06 | ||
6NIY | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcitonin salmon
pubchem
|
Agonist | 3.3 | Active | 10.1021/ACSPTSCI.8B00056 | 2019-01-23 | |
7M3F | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcium
pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem cinacalcet pubchem gtoplig chembl_ligand drugbank drug_central |
AgonistPAMPAM | 2.8 | Active | 10.1038/S41586-021-03691-0 | 2021-06-30 | |
7EZK | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCK-8
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 3.1 | Active | 2021-08-25 | ||
4BV0 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | NA | E. coli BL21(DE3) | Bacteria | 3 chemicals | 3 steps | vapour diffusion | sitting drops | 5 chems | 9.4-9.4 | 4°C |
neurotensin
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 3.1 | Inactive | 10.1073/PNAS.1317903111 | 2014-01-29 | ||
7WXW | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 10.1038/S41467-022-33173-4 | 2022-09-28 | |
4XT1 | US28 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 6.3-7.0 | 20°C |
CX3CL1
gtoplig
|
Agonist (partial) | 2.9 | Active | 10.1126/SCIENCE.AAA5026 | 2015-03-04 | |
4RWA | OPRD | δ | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.0-6.0 | 20°C |
DIPP-NH2
|
Antagonist | 3.3 | Inactive | 10.1038/NSMB.2965 | 2015-01-14 | |
5A8E | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 7.0-7.0 | 20°C |
7-methylcyanopindolo...
pubchem
|
Inverse agonist | 2.4 | Inactive | 10.1124/MOL.115.101030 | 2015-09-30 | |
5YWY | PE2R4 | EP4 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ONO-AE3-208
pubchem
|
Antagonist | 3.2 | Inactive | 10.1038/S41589-018-0131-3 | 2018-12-05 | |
7WY0 | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 10.1038/S41467-022-33173-4 | 2022-09-28 | |
7TD0 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2r)-2-Hydroxy-3-(Ph...
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-022-28417-2 | 2022-02-09 | |
7WU3 | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 10.1038/S41586-022-04580-W | 2022-04-27 | |
4ZJC | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.6-5.6 | 20°C |
SB-674042
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.8 | Inactive | 10.1038/NSMB.3183 | 2016-03-09 | |
7L1U | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Orexin-A
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41467-021-21087-6 | 2021-02-10 | |
7W0P | APJ | apelin | Apelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
apelin receptor earl...
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41594-022-00797-5 | 2022-07-27 | |
2R4S | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | vapour diffusion | hanging drop | 5 chems | 6.5-7.5 | 22°C | N/A | N/A | 3.4 | Inactive | 10.1038/NATURE06325 | 2007-11-06 | ||
3PWH | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 6 chems | 8.0-8.8 | 4°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 3.3 | Inactive | 10.1016/J.STR.2011.06.014 | 2011-09-07 | ||
6OYA | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (all-trans)
pubchem
|
Agonist | 3.3 | Active | 10.1016/J.MOLCEL.2019.06.007 | 2019-07-24 | |
6J21 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
aprepitant
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 3.2 | Inactive | 10.1038/S41467-019-08568-5 | 2019-03-06 | |
7JHJ | Q3KSP2 | BILF1 | Unclassified | A (Rhodopsin) | strain GD1 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 10.1016/J.IMMUNI.2021.06.001 | 2021-07-07 | |
7LD3 | AA1R | A1 | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
adenosine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
{2-Amino-4-[3,5-bis(... pubchem |
AgonistPAM | 3.2 | Active | 2021-09-08 | ||
7PP1 | P2Y12 | P2Y12 | P2Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
selatogrel
pubchem
|
Antagonist | 2.8 | Intermediate | 10.1016/j.bcp.2022.115291 | 2022-11-02 | |
7EPF | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(8~{R})-4-[2,4-Bis(f...
pubchem
|
NAM | 2.7 | Inactive | 10.1038/S41586-021-03641-W | 2021-06-23 | |
7D77 | AGRG3 | ADGRG3 | ADGRG | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
HYDROCORTISONE
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41586-020-03083-W | 2021-02-03 | |
7WV9 | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CP55940
pubchem
gtoplig
chembl_ligand
gtoplig
6-methyl-3-[(1S)-2-n... pubchem |
AgonistPAM | 3.4 | Active | 10.1038/S41589-022-01038-Y | 2022-06-15 | |
6TPG | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
EMPA
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.7 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
5NDD | PAR2 | PAR2 | Proteinase-activated | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-6.2 | 20°C |
AZ8838
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.8 | Intermediate | 10.1038/NATURE22309 | 2017-05-03 | |
5WB2 | Q80KM9 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 7 chems | 6.0-6.0 | 16-20°C |
CX3CL1
gtoplig
|
Agonist | 3.5 | Active | 10.7554/ELIFE.35850 | 2018-06-13 | |
7W0N | APJ | apelin | Apelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
apelin receptor earl...
pubchem
|
Agonist | 4.2 | Active | 10.1038/S41594-022-00797-5 | 2022-07-27 | |
3OE0 | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
CVX15
|
Antagonist | 2.9 | Inactive | 10.1126/SCIENCE.1194396 | 2010-10-27 | |
7SBF | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-[(2S)-2-(dimethyla...
pubchem
|
Agonist | 2.9 | Active | 10.1002/ANIE.202200269 | 2022-04-20 | |
7Y15 | MRGRD | MRGPRD | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 2022-07-20 | ||
6H7L | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Dobutamine
pubchem
|
Agonist | 2.7 | Active | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | |
7RA3 | GIPR | GIP | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
gastric inhibitory p...
pubchem
|
Agonist | 3.2 | Active | 10.1073/PNAS.2116506119 | 2022-04-13 | |
7EW0 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ozanimod
pubchem
gtoplig
drug_central
chembl_ligand
drugbank
|
Agonist | 3.4 | Active | 10.1038/S41422-021-00566-X | 2021-09-29 | |
6VCB | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
glucagon-like peptid...
pubchem
gtoplig
chembl_ligand
gtoplig
pubchem
pubchem
LSN3160440 pubchem |
AgonistPAM | 3.3 | Active | 10.1038/S41589-020-0589-7 | 2020-07-22 | |
7RM5 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.8 | Inactive | 10.1073/PNAS.2106041118 | 2021-09-08 | |
6TP6 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
filorexant
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.3 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
6MET | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Envelope glycoprotei...
|
Antagonist | 4.5 | Inactive | 10.1038/S41586-018-0804-9 | 2018-12-12 | |
6VJM | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 4.0 | Inactive | 10.1038/S41586-020-2408-4 | 2020-06-10 | |
2ZIY | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Japanese flying squid | NA | Native | Squid | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 7.0-7.0 | 20°C |
Retinal (11-cis)
pubchem
|
Inverse agonist | 3.7 | Inactive | 10.1074/JBC.C800040200 | 2008-05-06 | ||
6K41 | ADA2B | α2B | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dexmedetomidine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.9 | Active | 10.1038/S41589-020-0492-2 | 2020-04-15 | |
6ME4 | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-iodo-melatonin
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.2 | Inactive | 10.1038/S41586-019-1141-3 | 2019-04-24 | |
7DTT | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcium
pubchem
|
Agonist | 3.8 | Active | 10.1038/S41422-021-00474-0 | 2021-03-10 | |
7WU2 | AGRD1 | ADGRD1 | ADGRD | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 10.1038/S41586-022-04580-W | 2022-04-27 | |
6TO7 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
suvorexant
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Antagonist | 2.3 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
7VVK | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
teriparatide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
pubchem
pubchem
pubchem
pubchem
|
Agonist | 3.3 | Active | 2022-08-03 | ||
6D26 | PD2R2 | DP2 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
fevipiprant
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.8 | Inactive | 10.1016/J.MOLCEL.2018.08.009 | 2018-10-03 | |
5NLX | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.1 | Inactive | 10.1038/S41467-017-00630-4 | 2017-09-27 | |
7T6T | FPR1 | FPR1 | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
synthetic peptide
|
Agonist | 3.2 | Active | 2022-03-30 | ||
5IU4 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20 |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.7 | Inactive | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | |
7VLA | CCR1 | CCR1 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCL15(27-92)
|
Agonist | 2.7 | Active | 10.1038/S41589-021-00918-Z | 2022-03-23 | |
7F1O | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dopamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.1 | Active | 2022-06-15 | ||
6WGT | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Lysergide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.4 | Inactive | 10.1016/J.CELL.2020.08.024 | 2020-09-23 | |
7XTB | 5HT6R | 5-HT6 | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-hydroxytryptamine
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.3 | Active | 10.1016/J.MOLCEL.2022.05.031 | 2022-07-27 | |
7DD7 | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-tryptophan
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
evocalcet pubchem gtoplig drug_central chembl_ligand drugbank Calcium pubchem |
PAMPAMAgonist | 3.2 | Active | 10.1126/SCIADV.ABG1483 | 2021-06-16 | |
6E59 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L760735
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.4 | Inactive | 10.1073/PNAS.1812717115 | 2018-12-12 | |
5K2C | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.9 | Inactive | 10.1126/SCIADV.1600292 | 2016-09-21 | |
7VV0 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PAMP-12
pubchem
|
Agonist | 3.5 | Active | 2021-12-01 | ||
7XAT | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SOMATOSTATIN
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41421-022-00405-2 | 2022-08-31 | |
3OAX | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 6.0-6.0 | 283 K |
Retinal (11-cis)
pubchem
|
Inverse agonist | 2.6 | Inactive | 10.1016/J.BPJ.2010.08.003 | 2011-01-19 | ||
7T6S | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-(4-chlorophenyl)-N...
pubchem
|
Agonist | 3.0 | Active | 2022-03-30 | ||
7SHE | GP158 | GPR158 | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.4 | Inactive | 34793198 | 2021-12-01 | |
5ZBH | NPY1R | Y1 | Neuropeptide Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
BMS-193885
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/S41586-018-0046-X | 2018-04-25 | |
7FII | LSHR | LH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Choriogonadotropin b...
gtoplig
Glycoprotein alpha gtoplig |
AgonistAgonist | 4.3 | Active | 10.1038/S41586-021-03924-2 | 2021-09-29 | |
6ME3 | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-phenylmelatonin
pubchem
|
Agonist | 2.9 | Inactive | 10.1038/S41586-019-1141-3 | 2019-04-24 | |
7BTS | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(-)-adrenaline
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41422-020-00424-2 | 2020-12-02 | |
8HA0 | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
teriparatide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
pubchem
pubchem
pubchem
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41401-022-01032-Z | 2022-12-21 | |
7EJX | GPR88 | GPR88 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 2 [PMID: 24...
pubchem
gtoplig
chembl_ligand
|
PAM | 2.4 | Active | 2022-04-13 | ||
7X10 | AGRL3 | ADGRL3 | ADGRL | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1016/J.MOLCEL.2022.10.009 | 2022-11-09 | |
7FIG | LSHR | LH | Glycoprotein hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Choriogonadotropin b...
gtoplig
Glycoprotein alpha gtoplig |
AgonistAgonist | 3.9 | Active | 10.1038/S41586-021-03924-2 | 2021-09-29 | |
5ZKC | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-methyl scopolamine
pubchem
gtoplig
drugbank
gtoplig
|
Antagonist | 2.3 | Inactive | 10.1038/S41589-018-0152-Y | 2018-11-21 | |
7LLL | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
exendin-4
pubchem
gtoplig
pubchem
|
Agonist | 3.7 | Active | 10.1038/S41467-021-27760-0 | 2022-01-12 | |
4Z34 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.5-5.5 | 20°C |
ONO-9780307
pubchem
gtoplig
|
Antagonist | 3.0 | Inactive | 10.1016/J.CELL.2015.06.002 | 2015-06-03 | |
2Y03 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drops | 6 chems | 8.5-8.5 | 4°C |
LEVISOPRENALINE
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 2.9 | Inactive | 10.1038/NATURE09746 | 2011-01-12 | ||
2VT4 | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | hanging drop | 4 chems | 6.9-7.3 | 18°C |
(S)-Cyanopindolol
pubchem
|
Antagonist | 2.7 | Inactive | 10.1038/NATURE07101 | 2008-06-24 | ||
7SRS | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Lysergide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.3 | Active | 10.1016/J.NEURON.2022.08.006 | 2022-09-21 | |
6MH8 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 4.2 | Inactive | 10.1107/S205225251900263X | 2019-04-24 | |
7F6H | BKRB2 | B2 | Bradykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
bradykinin
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
|
Agonist | 2.9 | Active | 2022-01-05 | ||
6DDF | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | Cryo-EM | Gatan K2 Summit direct electron camera , 300kV | 5 chems | 7.5-7.5 | 4°C |
DAMGO
pubchem
gtoplig
chembl_ligand
chembl_ligand
|
Agonist | 3.5 | Active | 10.1038/S41586-018-0219-7 | 2018-06-13 | ||
4ZWJ | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Human | Transient_transfection | HEK293S(TetR)-GnTI- | Mammalian | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monopalmitolein (9.7 MAG) | 5 chems | 5.0-5.0 | 20°C |
Apo (no ligand)
|
Apo (no ligand) | 3.3 | Active | 10.1038/NATURE14656 | 2015-07-29 | |
7Y27 | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SOMATOSTATIN
chembl_ligand
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41589-022-01130-3 | 2022-10-19 | |
7TZF | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
amylin peptide
|
Agonist | 2.4 | Active | 2022-03-23 | ||
8F7Q | OPRM | μ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
β-endorphin
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | |
7YU6 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2~{R})-2-[5-(2-hex...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41467-022-33121-2 | 2022-10-05 | |
7E6U | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 6.0 | Inactive | 10.7554/ELIFE.68578 | 2021-09-22 | |
7RKF | US28 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Fractalkine
pubchem
|
Agonist | 4.0 | Active | 10.1126/SCIADV.ABL5442 | 2022-01-26 | |
5NX2 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | vapour diffusion | Sitting drop | 4 chems | 8.0-9.0 | 10°C |
Truncated protein ag...
|
Agonist | 3.7 | Intermediate | 10.1038/NATURE22800 | 2017-06-14 | ||
8DWG | MRGX1 | MRGPRX1 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Proenkephalin-A
2-(Cyclopropanesulfo... pubchem |
AgonistPAM | 2.7 | Active | 10.1038/S41589-022-01173-6 | 2022-11-02 | |
7Y24 | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Octreotide
|
Agonist | 3.3 | Active | 10.1038/S41589-022-01130-3 | 2022-10-19 | |
6OT0 | SMO | SMO | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
24,25-Epoxy-choleste...
pubchem
|
Agonist | 3.9 | Active | 10.1038/S41586-019-1286-0 | 2019-06-12 | |
4MBS | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C |
maraviroc
pubchem
gtoplig
drugbank
chembl_ligand
gtoplig
|
Antagonist | 2.7 | Inactive | 10.1126/SCIENCE.1241475 | 2013-09-11 | |
7E32 | 5HT1D | 5-HT1D | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-hydroxytryptamine
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.9 | Active | 10.1038/S41586-021-03376-8 | 2021-04-21 | |
5OLO | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
tozadenant
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 3.1 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
3VG9 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | P.pastoris | P. pastoris SMD1163 | Yeast | 2 chemicals | 2 steps | vapour diffusion | hanging drop | 4 chems | 6.5-6.5 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.7 | Inactive | 10.1038/NATURE10750 | 2012-02-01 | ||
7F4D | MSHR | MC1 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
INTERMEDINE
chembl_ligand
pubchem
pubchem
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41422-021-00557-Y | 2021-09-08 | |
8DPI | 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lorcaserin
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.4 | Active | 10.1016/J.CELREP.2022.111211 | 2022-08-24 | |
6FJ3 | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ePTH
|
Agonist (partial) | 2.5 | Inactive | 10.1038/S41594-018-0151-4 | 2018-11-21 | |
7UL2 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
meclinertant
pubchem
gtoplig
chembl_ligand
drugbank
|
Inverse agonist | 2.4 | Inactive | 2022-06-29 | ||
6M1H | PACR | PAC1 | VIP and PACAP | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
maxadilan
gtoplig
pubchem
|
Agonist | 3.6 | Active | 10.1038/S41422-020-0280-2 | 2020-03-11 | |
3D4S | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C |
timolol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Inverse agonist | 2.8 | Inactive | 10.1016/J.STR.2008.05.001 | 2008-06-17 | |
6K1Q | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
IRL 2500
pubchem
gtoplig
chembl_ligand
|
Inverse agonist | 2.7 | Inactive | 10.1038/S42003-019-0482-7 | 2019-07-17 | |
3CAP | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drop | 4 chems | 5.6-5.6 | 4°C |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Active | 10.1038/NATURE07063 | 2008-06-24 | ||
4PY0 | P2Y12 | P2Y12 | P2Y | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-6.0 | 20°C |
2MeSATP
pubchem
gtoplig
chembl_ligand
|
Agonist (partial) | 3.1 | Intermediate | 10.1038/NATURE13288 | 2014-04-30 | |
6GT3 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
imaradenant
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.0 | Inactive | 2019-06-26 | ||
8E9Y | ACM3 | M3 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Clozapine N-oxide
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41586-022-05489-0 | 2022-11-30 | |
7DD5 | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcium
pubchem
NPS 2143 pubchem gtoplig chembl_ligand drugbank L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem |
AgonistNAMPAM | 3.2 | Inactive | 10.1126/SCIADV.ABG1483 | 2021-06-16 | |
7EVY | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
siponimod
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 3.0 | Active | 10.1038/S41422-021-00566-X | 2021-09-29 | |
7DHI | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
levosalbutamol
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 3.3 | Active | 10.1093/NSR/NWAA284 | 2020-12-16 | |
7BZ2 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
arformoterol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.8 | Active | 10.1038/S41421-020-0176-9 | 2020-08-05 | |
6WWZ | CCR6 | CCR6 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCL20
gtoplig
|
Agonist | 3.3 | Active | 10.1038/S41467-020-16820-6 | 2020-06-24 | |
7WY5 | AGRL3 | ADGRL3 | ADGRL | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.8 | Active | 10.1016/J.MOLCEL.2022.10.009 | 2022-10-26 | |
7VDM | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 3.0 | Active | 2021-12-01 | ||
7DD6 | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcium
pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem |
AgonistPAM | 3.2 | Active | 10.1126/SCIADV.ABG1483 | 2021-06-16 | |
8EFO | OPRM | μ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PZM21
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 2.8 | Active | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | |
7W57 | NMUR2 | NMU2 | Neuromedin U | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Neuromedin-S
|
Agonist | 3.2 | Active | 10.1038/S41467-022-29683-W | 2022-04-20 | |
7CUM | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Unknown ligand
CGP 54626A pubchem gtoplig chembl_ligand gtoplig |
NAMAntagonist | 3.5 | Inactive | 10.1016/J.JMB.2020.09.023 | 2020-11-11 | |
7F53 | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
α-MSH
pubchem
gtoplig
|
Agonist | 3.0 | Active | 2021-11-03 | ||
7F8Y | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
DEVAZEPIDE
chembl_ligand
pubchem
|
Antagonist | 2.5 | Inactive | 2021-10-13 | ||
7XMS | SSR4 | SST4 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SOMATOSTATIN
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 10.1038/S41422-022-00679-X | 2022-08-03 | |
7UL4 | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
alvimopan
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 2.8 | Inactive | 2022-06-29 | ||
7S8M | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cortistatin 14
pubchem
|
Agonist | 2.5 | Active | 10.1038/S41586-021-04126-6 | 2021-11-17 | |
7XTQ | GPBAR | GPBA | Bile acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL2181246
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1073/PNAS.2117054119 | 2022-07-06 | |
7WIC | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SOMATOSTATIN
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41422-022-00669-Z | 2022-06-01 | |
3C9L | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | NA | NA | 1 chemicals | 1 steps | NA | NA | NA | 1 chems | 0.0-0.0 | NA |
Retinal (11-cis)
pubchem
|
Inverse agonist | 2.7 | Inactive | 10.1107/S0907444908017162 | 2008-08-05 | |
6Z10 | SUCR1 | succinate | Succinate | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4751488
chembl_ligand
pubchem
|
Antagonist | 2.3 | Intermediate | 10.1021/acs.jmedchem.0c01020 | 2020-09-16 | |
7W0M | APJ | apelin | Apelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(1R,2S)-N-[4-(2,6-di...
pubchem
|
Agonist | 3.7 | Active | 10.1038/S41594-022-00797-5 | 2022-07-27 | |
7O7F | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCL5
gtoplig
|
Agonist | 3.2 | Active | 10.1126/SCIADV.ABG8685 | 2021-06-30 | |
7X8S | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2,4-bis(3-methoxy-4-...
pubchem
|
Agonist | 3.1 | Active | 10.1073/PNAS.2200155119 | 2022-06-29 | |
3VGA | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | P.pastoris | P. pastoris SMD1163 | Yeast | 2 chemicals | 2 steps | vapour diffusion | hanging drop | 4 chems | 6.5-6.5 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 3.1 | Inactive | 10.1038/NATURE10750 | 2012-02-01 | ||
6PS3 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3799125
chembl_ligand
pubchem
|
Antagonist | 2.5 | Inactive | 10.1107/S2052252519013137 | 2019-11-13 | |
7TD2 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2r)-2-Hydroxy-3-(Ph...
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41467-022-28417-2 | 2022-02-09 | |
7F58 | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
THIQ
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.1 | Active | 2021-11-03 | ||
8DCR | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Dobutamine
pubchem
|
Agonist | 2.6 | Active | 10.1038/S41467-022-31823-1 | 2022-07-27 | |
7SK5 | ACKR3 | ACKR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Stromal cell-derived...
|
Agonist | 4.0 | Active | 10.1126/SCIADV.ABN8063 | 2022-07-27 | |
7CX2 | PE2R2 | EP2 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PGE2
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
|
Agonist | 2.8 | Active | 10.1126/SCIADV.ABF1268 | 2021-05-05 | |
7R0C | V2R | V2 | Vasopressin and oxytocin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 4.7 | Active | 10.1126/SCIADV.ABO7761 | 2022-09-14 | |
6E3Y | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcitonin gene-rela...
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-018-0535-Y | 2018-09-19 | |
7Y13 | MRGRD | MRGPRD | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 2022-07-20 | ||
3AYN | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Japanese flying squid | NA | Native | Squid | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 5 chems | 6.0-6.0 | 4°C |
Retinal (9-cis)
pubchem
|
Inverse agonist | 2.7 | Inactive | 10.1016/J.JMB.2011.08.044 | 2011-08-17 | ||
4GRV | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C |
JMV431
gtoplig
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1038/NATURE11558 | 2012-10-17 | |
6XBJ | SMO | SMO | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cholesterol
pubchem
|
Agonist | 3.9 | Active | 10.1038/S41589-020-0646-2 | 2020-09-30 | |
7SK3 | ACKR3 | ACKR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CXCL12α
gtoplig
|
Agonist | 3.8 | Active | 10.1126/SCIADV.ABN8063 | 2022-07-27 | |
7XNA | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CYN 154806
pubchem
|
Antagonist | 2.7 | Inactive | 10.1038/S41422-022-00679-X | 2022-08-03 | |
8CU6 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LJ-4517
gtoplig
pubchem
|
Antagonist | 2.8 | Inactive | 10.1021/ACS.JMEDCHEM.2C00462 | 2022-08-31 | |
7JOZ | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL4453318
chembl_ligand
pubchem
|
Agonist | 3.8 | Active | 2021-04-14 | ||
5XPR | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-7.0 | 20°C |
Apo (no ligand)
|
Apo (no ligand) | 3.6 | Inactive | 10.1038/NSMB.3450 | 2017-08-16 | |
7T6V | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
synthetic peptide
|
Agonist | 3.1 | Active | 2022-03-30 | ||
6AK3 | PE2R3 | EP3 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PGE2
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
|
Agonist | 2.9 | Active | 10.1038/S41589-018-0171-8 | 2018-12-05 | |
7DB6 | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ramelteon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.3 | Active | 10.1038/S41594-021-00634-1 | 2021-08-18 | |
5IUA | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20 |
2-(Furan-2-yl)-5-N-[...
pubchem
|
Antagonist | 2.2 | Inactive | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | |
7YU3 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[(2~{R})-2-[5-(2-hex...
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41467-022-33121-2 | 2022-10-05 | |
7F9Y | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ghrelin
gtoplig
|
Agonist | 2.9 | Active | 2021-08-18 | ||
6WW2 | FZD5 | FZD5 | Frizzled | F (Frizzled) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.7 | Inactive | 10.7554/ELIFE.58464 | 2020-08-19 | |
7VV4 | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cortistatin 14
pubchem
|
Agonist | 3.0 | Active | 2021-12-01 | ||
6LI1 | GPR52 | GPR52 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.9 | Inactive | 10.1038/S41586-020-2019-0 | 2020-02-26 | |
7VVN | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
teriparatide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
pubchem
pubchem
pubchem
pubchem
|
Agonist | 3.8 | Active | 2022-08-03 | ||
3PBL | DRD3 | D3 | Dopamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.5-7.5 | 20°C |
eticlopride
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.9 | Inactive | 10.1126/SCIENCE.1197410 | 2010-11-03 | |
6KQI | CNR1 | CB1 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Org27569
pubchem
gtoplig
chembl_ligand
CP55940 pubchem gtoplig chembl_ligand gtoplig |
NAMAgonist | 3.3 | Inactive | 10.1038/S41589-019-0387-2 | 2019-10-23 | |
7SF8 | AGRG1 | ADGRG1 | ADGRG | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 2.7 | Active | 10.1038/S41586-022-04575-7 | 2022-04-27 | |
5UEN | AA1R | A1 | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.0-8.0 | 20°C |
DU172
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.2 | Inactive | 10.1016/j.cell.2017.01.042 | 2017-03-01 | |
6TP4 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ACT-462206
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.0 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
7MBX | CCKAR | CCK1 | Cholecystokinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL216166
chembl_ligand
pubchem
|
Agonist | 2.0 | Active | 2021-05-26 | ||
7CFN | GPBAR | GPBA | Bile acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
INT-777
pubchem
INT-777 pubchem |
AgonistPAM | 3.0 | Active | 10.1038/S41586-020-2569-1 | 2020-09-09 | |
7C7Q | GABR2 | GABAB2 | GABAB | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(-)-baclofen
pubchem
gtoplig
chembl_ligand
drugbank
drugbank
gtoplig
pubchem
BHFF pubchem |
AgonistPAM | 3.0 | Active | 10.1038/S41422-020-0350-5 | 2020-07-01 | |
5NM4 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.7 | Inactive | 10.1038/S41467-017-00630-4 | 2017-09-27 | |
6D9H | AA1R | A1 | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | Cryo-EM | Volta phase plate(FEI), FEI Titan Krios@300kV, Gatan K2 Summit direct electron camera , Gatan Quantum energy filter | 6 chems | 7.4-7.4 | 4°C |
adenosine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.6 | Active | 10.1038/S41586-018-0236-6 | 2018-06-20 | ||
7X5H | 5HT5A | 5-HT5A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-CT
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.1 | Active | 10.1038/S41421-022-00412-3 | 2022-09-14 | |
7XJI | ADRB3 | β3 | Adrenoceptors | A (Rhodopsin) | Dog | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
3-[3-[2-[[(2~{S})-2-...
pubchem
|
Agonist | 3.9 | Active | 10.1016/J.BBRC.2022.04.065 | 2022-05-04 | |
6TQ7 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SB-334867
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.7 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
2YCZ | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | vapour diffusion | NA | 3 chems | 6.9-7.3 | NA |
Iodocyanopindolol
pubchem
|
Antagonist | 3.7 | Inactive | 10.1073/PNAS.1100185108 | 2011-06-01 | ||
7M3G | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcium
pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem evocalcet pubchem gtoplig drug_central chembl_ligand drugbank |
AgonistPAMPAM | 2.5 | Active | 10.1038/S41586-021-03691-0 | 2021-06-30 | |
5OM1 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
CHEMBL2024114
chembl_ligand
pubchem
|
Antagonist | 2.1 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
6OFJ | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 4.5 | Inactive | 10.1074/JBC.RA119.010089 | 2019-08-21 | |
6BQH | 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
ritanserin
pubchem
gtoplig
chembl_ligand
drugbank
|
Inverse agonist | 2.7 | Inactive | 10.1016/j.cell.2018.01.001 | 2018-02-14 | |
7Y89 | GPR17 | GPR17 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.0 | Active | 10.1002/MCO2.159 | 2022-10-12 | |
7WIG | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
~{N}-[(2~{R})-1-[[(1...
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41422-022-00669-Z | 2022-06-01 | |
5CGC | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-6.8 | 20°C |
CHEMBL3603915
chembl_ligand
pubchem
|
NAM | 3.1 | Inactive | 10.1021/acs.jmedchem.5b00892 | 2015-08-12 | |
6HLL | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CP 99994
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.3 | Inactive | 10.1038/S41467-018-07939-8 | 2019-01-16 | |
7SIM | CASR | CaS | Calcium-sensing | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cyclomethyltryptopha...
pubchem
|
Agonist | 2.7 | Active | 10.1073/PNAS.2115849118 | 2022-01-19 | |
5OLH | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
vipadenant
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.6 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
6DDE | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | Cryo-EM | Gatan K2 Summit direct electron camera , 300kV | 5 chems | 7.5-7.5 | 4°C |
DAMGO
pubchem
gtoplig
chembl_ligand
chembl_ligand
|
Agonist | 3.5 | Active | 10.1038/S41586-018-0219-7 | 2018-06-13 | ||
7XKF | AGRG2 | ADGRG2 | ADGRG | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PRASTERONE
chembl_ligand
pubchem
|
Agonist | 2.4 | Active | 2022-08-10 | ||
7X9C | NPY4R | Y4 | Neuropeptide Y | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Pancreatic polypepti...
pubchem
|
Agonist | 3.0 | Active | 10.1126/SCIADV.ABM1232 | 2022-05-18 | |
7RGP | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
tirzepatide
pubchem
gtoplig
|
Agonist | 2.9 | Active | 10.1073/PNAS.2116506119 | 2022-04-13 | |
7VBH | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Peptide 20
|
Agonist | 3.0 | Active | 10.1038/S41467-022-28683-0 | 2022-04-06 | |
7K15 | LT4R1 | BLT1 | Leukotriene | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-(tert-butylsulfony...
pubchem
|
Antagonist | 2.9 | Inactive | 2021-02-17 | ||
6LW5 | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL552527
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-020-15009-1 | 2020-03-25 | |
6FFI | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.5-6.8 | 20°C |
methoxy-MPEP
pubchem
gtoplig
chembl_ligand
gtoplig
|
NAM | 2.2 | Inactive | 10.1021/ACS.JMEDCHEM.7B01722 | 2018-03-07 | |
4MQT | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.2-7.9 | 20°C |
iperoxo
pubchem
gtoplig
chembl_ligand
LY2119620 pubchem gtoplig chembl_ligand |
AgonistPAM | 3.7 | Active | 10.1038/NATURE12735 | 2013-11-27 | |
7PX4 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Preladenant conjugat...
pubchem
|
Antagonist | 2.3 | Inactive | 10.1002/ANIE.202115545 | 2022-03-02 | |
7F9Z | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
GHRP-6
pubchem
gtoplig
|
Agonist | 3.2 | Active | 2021-08-18 | ||
6JZH | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.3 | Inactive | 10.1107/S1600576719012846 | 2019-10-30 | |
5WS3 | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 9 chemicals | 9 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 5.8-6.2 | 20°C |
EMPA
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.3 | Inactive | 10.1016/J.STR.2017.11.005 | 2017-12-13 | |
7D68 | GLP2R | GLP-2 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
glucagon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
gtoplig
pubchem
pubchem
pubchem
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41422-020-00442-0 | 2020-12-16 | |
6VMS | DRD2 | D2 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
bromocriptine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.8 | Active | 10.1038/S41586-020-2379-5 | 2020-06-17 | |
5DYS | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Stable_cells | HEK293S-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Sitting drop | 4 chems | 4.5-4.5 | 20°C |
Retinal (all-trans)
pubchem
|
Agonist | 2.3 | Active | 10.15252/EMBR.201642671 | 2016-08-10 | ||
8DCS | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
4-{[(2S)-3-(tert-but...
pubchem
|
Agonist | 2.5 | Active | 10.1038/S41467-022-31823-1 | 2022-07-27 | |
7MTB | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (all-trans)
pubchem
|
Agonist | 4.0 | Active | 10.1038/S41586-021-03721-X | 2021-07-07 | |
5XF1 | GLR | glucagon | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C |
NNC0640
pubchem
gtoplig
|
NAM | 3.2 | Inactive | 10.1038/NATURE22363 | 2017-05-24 | |
7RKN | US28 | US28 | Unclassified | A (Rhodopsin) | strain AD169 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Fractalkine
pubchem
|
Agonist | 3.6 | Active | 10.1126/SCIADV.ABL5442 | 2022-01-26 | |
6MXT | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
salmeterol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.0 | Active | 10.1038/s41589-018-0145-x | 2018-11-14 | |
7X2F | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dopamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
LY3154207 pubchem gtoplig chembl_ligand |
AgonistAgonist | 3.0 | Active | 10.1038/S41467-022-30929-W | 2022-06-15 | |
3UON | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.5-7.5 | 19.85°C |
CHEMBL558910
chembl_ligand
pubchem
|
Antagonist | 3.0 | Inactive | 10.1038/NATURE10753 | 2012-02-01 | |
4QIM | SMO | SMO | Frizzled | F (Frizzled) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 7.2-7.2 | 20°C |
ANTA XV
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.6 | Inactive | 10.1038/NCOMMS5355 | 2014-07-23 | |
7S8L | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Cortistatin 14
pubchem
|
Agonist | 2.5 | Active | 2021-11-17 | ||
7VQX | VIPR2 | VPAC2 | VIP and PACAP | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PACAP-27
pubchem
gtoplig
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41467-022-30041-Z | 2022-05-18 | |
7MTQ | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 3.7 | Inactive | 10.1038/S41586-021-03680-3 | 2021-07-07 | |
7TS0 | CRFR2 | CRF2 | Corticotropin-releasing factor | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Urocortin
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-022-33851-3 | 2022-11-09 | |
5JQH | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | 7.7 MAG | 5 chems | 7.5-7.5 | 23°C |
Carazolol
pubchem
|
Inverse agonist | 3.2 | Inactive | 10.1038/NATURE18636 | 2016-07-13 | |
7E9G | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JNJ-40411813
pubchem
gtoplig
chembl_ligand
drugbank
eglumegad pubchem gtoplig chembl_ligand gtoplig |
PAMAgonist | 3.5 | Intermediate | 10.1038/S41586-021-03495-2 | 2021-06-23 | |
5OLG | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 1.9 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
7VDH | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
compound 48/80
pubchem
gtoplig
|
Agonist | 2.9 | Active | 2021-12-01 | ||
5VRA | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 4.6-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.4 | Inactive | 10.1038/NPROT.2017.135 | 2017-12-13 | |
7AD3 | STE2 | STE2 | STE2 | D1 (Ste2-like fungal pheromone) | strain ATCC 204508 / S288c | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Alpha-factor mating ...
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41586-020-2994-1 | 2020-12-09 | |
7B6W | ADA1B | α1B | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(+)-cyclazosin
pubchem
gtoplig
chembl_ligand
|
Inverse agonist | 2.9 | Inactive | 10.1038/s41467-021-27911-3 | 2022-01-12 | |
7WI8 | GRM3 | mGlu3 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY341495
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 4.2 | Inactive | 10.1038/S41422-022-00623-Z | 2022-03-16 | |
6FKD | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | Baculovirus | HEK293S(TetR)-GnTI- | Mammalian | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 4.5-4.5 | 20°C |
5-chloro-2-(2-oxo-2-...
pubchem
|
Agonist | 2.5 | Active | 10.1073/PNAS.1718084115 | 2018-04-04 | ||
6HLO | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
aprepitant
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 2.4 | Inactive | 10.1038/S41467-018-07939-8 | 2019-01-16 | |
7X2D | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
TAVAPADON
chembl_ligand
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41467-022-30929-W | 2022-06-15 | |
6PS8 | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-phenylmelatonin
pubchem
|
Agonist | 3.3 | Inactive | 10.1107/S2052252519013137 | 2019-11-13 | |
7WKD | TRFR | TRH1 | Thyrotropin-releasing hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
TRH
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41422-022-00641-X | 2022-06-15 | |
4Z36 | LPAR1 | LPA1 | Lysophospholipid (LPA) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.5-5.5 | 20°C |
ONO-3080573
pubchem
gtoplig
|
Antagonist | 2.9 | Inactive | 10.1016/J.CELL.2015.06.002 | 2015-06-03 | |
8F7X | OPRX | NOP | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
nociceptin/orphanin ...
pubchem
gtoplig
chembl_ligand
gtoplig
pubchem
pubchem
|
Agonist | 3.3 | Active | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | |
7DH5 | ADRB3 | β3 | Adrenoceptors | A (Rhodopsin) | Dog | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
mirabegron
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.2 | Active | 10.1016/J.MOLCEL.2021.06.024 | 2021-08-04 | |
6DRX | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lisuride
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Antagonist | 3.1 | Intermediate | 10.1038/s41594-018-0116-7 | 2018-08-29 | |
5YHL | PE2R4 | EP4 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ONO-AE3-208-Br
pubchem
|
Antagonist | 4.2 | Inactive | 10.1038/S41589-018-0131-3 | 2018-12-05 | |
6Z8N | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Rat | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2~{S})-4-methyl-2-[...
pubchem
|
Agonist | 2.8 | Intermediate | 10.1126/sciadv.abe5504 | 2021-02-10 | |
7NA8 | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ibutamoren
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.7 | Active | 10.1038/S41467-021-26735-5 | 2021-12-15 | |
6J20 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
aprepitant
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
|
Antagonist | 2.7 | Inactive | 10.1038/S41467-019-08568-5 | 2019-03-06 | |
7TYL | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Amylin rat
pubchem
|
Agonist | 3.3 | Active | 2022-03-23 | ||
7WC4 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
5-hydroxytryptamine
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.2 | Inactive | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | |
8HAF | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PTHrP-(1-36)
gtoplig
|
Agonist | 3.3 | Active | 10.1038/S41401-022-01032-Z | 2022-12-21 | |
5UVI | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 3.2 | Inactive | 10.1107/S205225251700570X | 2017-05-24 | |
7XN9 | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-054,522
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.6 | Inactive | 10.1038/S41422-022-00679-X | 2022-08-03 | |
6C1R | C5AR1 | C5a1 | Complement peptide | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.5-6.5 | 10°C |
PMX53
pubchem
gtoplig
chembl_ligand
avacopan pubchem gtoplig chembl_ligand drugbank |
AntagonistNAM | 2.2 | Inactive | 10.1038/S41594-018-0067-Z | 2018-05-30 | |
7T11 | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Octreotide
|
Agonist | 2.7 | Active | 10.1038/S41594-022-00727-5 | 2022-03-09 | |
5IU7 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
2-(Furan-2-yl)-5-N-[...
pubchem
|
Antagonist | 1.9 | Inactive | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | |
7TYN | CALCR | CT | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Calcitonin salmon
pubchem
|
Agonist | 2.6 | Active | 2022-03-30 | ||
7X2C | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
fenoldopam
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
gtoplig
chembl_ligand
pubchem
pubchem
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1038/S41467-022-30929-W | 2022-06-29 | |
7SK6 | ACKR3 | ACKR3 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Stromal cell-derived...
|
Agonist | 4.0 | Active | 10.1126/SCIADV.ABN8063 | 2022-07-27 | |
7WVW | FPR2 | FPR2/ALX | Formylpeptide | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
FME-TYR-PHE-ILE-ASN-...
|
Agonist | 3.1 | Active | 10.1038/S41467-022-29361-X | 2022-04-13 | |
8EF5 | OPRM | μ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
fentanyl
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.3 | Active | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | |
7VGZ | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ramelteon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.3 | Active | 2022-03-02 | ||
7VVJ | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PTHrP[1-36]
|
Agonist | 3.2 | Active | 2022-08-03 | ||
7EIB | BKRB1 | B1 | Bradykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[des-Arg<sup>10</sup...
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 3.0 | Active | 10.1038/S41594-021-00645-Y | 2021-10-13 | |
6BQG | 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
ergotamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.0 | Active | 10.1016/j.cell.2018.01.001 | 2018-02-14 | |
7V68 | ACM4 | M4 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY2119620
pubchem
gtoplig
chembl_ligand
iperoxo pubchem gtoplig chembl_ligand |
PAMAgonist | 3.4 | Active | 2022-05-11 | ||
7SHF | GP158 | GPR158 | C Orphans | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.4 | Inactive | 34793198 | 2021-12-01 | |
6H7J | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LEVISOPRENALINE
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 2.8 | Active | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | |
7MTS | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L-glutamic acid
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
pubchem
pubchem
2-methoxy-6-propyl-N... pubchem |
AgonistAgo-PAM | 3.2 | Active | 10.1038/S41586-021-03680-3 | 2021-07-07 | |
6AKX | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-[(1S)-3-{(3-exo)-3...
pubchem
|
Antagonist | 2.8 | Inactive | 10.1021/acs.jmedchem.8b01077 | 2018-10-24 | |
7MT9 | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Retinal (all-trans)
pubchem
|
Agonist | 7.0 | Active | 10.1038/S41586-021-03721-X | 2021-07-07 | |
5OLZ | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
CHEMBL2024114
chembl_ligand
pubchem
|
Antagonist | 1.9 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
7DUQ | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL410972
chembl_ligand
pubchem
pubchem
N-Tert-butyl-6,7-dic... pubchem |
AgonistAgo-PAM | 2.5 | Active | 10.1038/S41467-021-24058-Z | 2021-07-14 | |
6LI0 | GPR52 | GPR52 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
derivative 17 [Nakah...
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.2 | Inactive | 10.1038/S41586-020-2019-0 | 2020-02-26 | |
7UM6 | 5HT5A | 5-HT5A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lisuride
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.8 | Active | 10.1038/S41594-022-00796-6 | 2022-07-20 | |
7KI0 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
semaglutide
pubchem
gtoplig
chembl_ligand
drugbank
pubchem
|
Agonist | 2.5 | Active | 10.1016/J.CELREP.2021.109374 | 2021-08-04 | |
7XMR | SSR2 | SST2 | Somatostatin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SOMATOSTATIN
chembl_ligand
pubchem
|
Agonist | 3.1 | Active | 10.1038/S41422-022-00679-X | 2022-08-03 | |
7MTR | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-methoxy-6-propyl-N...
pubchem
L-glutamic acid pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem |
Ago-PAMAgonist | 3.3 | Active | 10.1038/S41586-021-03680-3 | 2021-07-07 | |
7F1Q | CCR5 | CCR5 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CCL3
gtoplig
|
Agonist | 2.9 | Active | 10.1038/S41467-021-24438-5 | 2021-07-14 | |
2YDV | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 4 chemicals | 4 steps | vapour diffusion | sitting drop | 5 chems | 6.4-6.4 | 4°C |
NECA
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 2.6 | Active | 10.1038/NATURE10136 | 2011-05-18 | ||
7WC5 | 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
psilocin
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.2 | Inactive | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | |
5ZTY | CNR2 | CB2 | Cannabinoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AM10257
gtoplig
pubchem
|
Antagonist | 2.8 | Inactive | 10.1016/J.CELL.2018.12.011 | 2019-01-30 | |
8E9W | ACM3 | M3 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL73538
chembl_ligand
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41586-022-05489-0 | 2022-11-30 | |
4DKL | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | Baculovirus | Sf9 | Insect | 12 chemicals | 12 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 20°C |
Methyl 4-[[(4R,4aS,7...
pubchem
|
Antagonist | 2.8 | Inactive | 10.1038/NATURE10954 | 2012-03-21 | |
7SRR | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Lysergide
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.9 | Active | 10.1016/J.NEURON.2022.08.006 | 2022-09-21 | |
7D3S | SCTR | secretin | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SECRETIN
chembl_ligand
pubchem
|
Agonist | 2.9 | Active | 10.1016/J.BBRC.2020.08.042 | 2020-11-04 | |
3REY | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | vapour diffusion | Sitting drop | 6 chems | 8.0-8.8 | 4°C |
xanthine amine conge...
pubchem
gtoplig
chembl_ligand
gtoplig
|
Antagonist | 3.3 | Inactive | 10.1016/J.STR.2011.06.014 | 2011-09-07 | ||
6O3C | SMO | SMO | Frizzled | F (Frizzled) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
SAG21k
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41586-019-1355-4 | 2019-07-03 | |
8EFB | OPRM | μ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
OLICERIDINE
chembl_ligand
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | |
7WBJ | VIPR2 | VPAC2 | VIP and PACAP | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PACAP-27
pubchem
gtoplig
pubchem
|
Agonist | 3.4 | Active | 10.1038/S41467-022-30041-Z | 2022-05-18 | |
8F7W | OPRK | κ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
dynorphin A-(1-8)
pubchem
gtoplig
chembl_ligand
pubchem
pubchem
|
Agonist | 3.2 | Active | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | |
5GLI | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.3-6.3 | 20°C |
Apo (no ligand)
|
Apo (no ligand) | 2.5 | Inactive | 10.1038/nature19319 | 2016-09-07 | |
3NYA | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.0-7.0 | 21-23°C |
CHEMBL1160734
chembl_ligand
pubchem
|
Antagonist | 3.2 | Inactive | 10.1021/JA105108Q | 2010-08-11 | |
7XRR | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lemborexant
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Antagonist | 2.9 | Inactive | 10.1016/J.STR.2022.11.001 | 2022-11-23 | |
7P00 | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 2.7 | Active | 10.1126/SCIADV.ABK2872 | 2021-12-15 | |
7VGY | MTR1A | MT1 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-iodo-melatonin
pubchem
gtoplig
chembl_ligand
drugbank
|
Agonist | 3.1 | Active | 2022-03-02 | ||
3NY9 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.5-8.0 | 20°C |
CHEMBL1233771
chembl_ligand
pubchem
|
Inverse agonist | 2.8 | Inactive | 10.1021/JA105108Q | 2010-08-11 | |
7W2Z | GHSR | ghrelin | Ghrelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Ghrelin
pubchem
|
Agonist | 2.8 | Active | 10.1038/S41467-022-27975-9 | 2022-01-19 | |
3DQB | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | hanging drops | 5 chems | 5.9-6.1 | 10°C |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Active | 10.1038/NATURE07330 | 2008-09-23 | ||
5OLV | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.3-5.4 | 20°C |
CHEMBL1671936
chembl_ligand
pubchem
|
Antagonist | 2.0 | Inactive | 10.1038/S41598-017-18570-W | 2018-01-17 | |
7VUY | MRGX2 | MRGPRX2 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PAMP-12
pubchem
|
Agonist | 2.8 | Active | 2021-12-01 | ||
7LCJ | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
danuglipron
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.8 | Active | 2021-01-20 | ||
3OE9 | CXCR4 | CXCR4 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 6.0-6.0 | 20°C |
isothiourea-1t
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.1 | Inactive | 10.1126/SCIENCE.1194396 | 2010-10-27 | |
5UNF | AGTR2 | AT2 | Angiotensin | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 7 chems | 8.0-8.0 | 20°C |
compound 1 [PMID: 28...
pubchem
gtoplig
chembl_ligand
|
Antagonist | 2.8 | Active | 10.1038/NATURE22035 | 2017-04-05 | |
4J4Q | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drop | 3 chems | 5.2-6.0 | 4°C |
B-Octylglucoside
pubchem
|
unknown | 2.7 | Active | 10.1002/ANIE.201302374 | 2013-10-30 | ||
6ZG9 | ACM1 | M1 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
7-fluoro-5-methyl-3-...
pubchem
|
Agonist | 2.5 | Inactive | 2021-10-06 | ||
7WCN | GP119 | GPR119 | GPR18, GPR55 and GPR119 | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AR231453
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.9 | Active | 10.1038/S41467-022-34696-6 | 2022-12-21 | |
6IGL | EDNRB | ETB | Endothelin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
IRL 1620
pubchem
gtoplig
chembl_ligand
gtoplig
pubchem
pubchem
|
Agonist (partial) | 2.7 | Inactive | 10.1038/S41467-018-07094-0 | 2018-11-21 | |
6H7M | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
levosalbutamol
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Agonist | 2.8 | Active | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | |
6PGS | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Geraniol
pubchem
|
unknown | 2.9 | Active | 2020-07-01 | ||
6LN2 | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
PF-06372222
pubchem
|
NAM | 3.2 | Inactive | 10.1038/S41467-020-14934-5 | 2020-03-18 | |
6TKO | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
arformoterol
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.3 | Active | 10.1038/S41586-020-2419-1 | 2020-06-17 | |
7EO2 | S1PR1 | S1P1 | Lysophospholipid (S1P) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(S)-FTY720-phosphate
pubchem
gtoplig
chembl_ligand
|
Agonist | 2.9 | Active | 10.1038/S41589-021-00930-3 | 2022-01-05 | |
5XSZ | Q08BG4 | LPA6 | Lysophospholipid (LPA) | A (Rhodopsin) | Zebrafish | Baculovirus | Sf9 | Insect | 8 chemicals | 8 steps | in meso/LCP | lipidic cubic phase | monoolein (9.9 MAG) | 6 chems | 6.0-6.0 | 20°C |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Intermediate | 10.1038/NATURE23448 | 2017-08-16 | |
7RMG | NK1R | NK1 | Tachykinin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
substance P
pubchem
gtoplig
chembl_ligand
gtoplig
gtoplig
|
Agonist | 3.0 | Active | 2021-11-03 | ||
6DRY | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
methylergonovine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 2.9 | Intermediate | 10.1038/s41594-018-0116-7 | 2018-08-29 | |
7KNT | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.2 | Inactive | 10.1126/SCIENCE.ABF7258 | 2021-02-24 | |
7EPE | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL3894759
chembl_ligand
pubchem
|
NAM | 2.5 | Inactive | 10.1038/S41586-021-03641-W | 2021-06-23 | |
6M1I | PACR | PAC1 | VIP and PACAP | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
[Ac-His<sup>1</sup>]...
gtoplig
chembl_ligand
pubchem
|
Agonist | 3.5 | Active | 10.1038/S41422-020-0280-2 | 2020-03-11 | |
7TUZ | GP183 | GPR183 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(2S,4aS,4bS,7R,8S,8a...
pubchem
|
Agonist | 3.1 | Active | 2022-04-13 | ||
7X1T | TRFR | TRH1 | Thyrotropin-releasing hormone | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
taltirelin
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.3 | Active | 10.1038/S41422-022-00646-6 | 2022-08-31 | |
5IUB | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20°C |
CHEMBL184061
chembl_ligand
pubchem
|
Antagonist | 2.1 | Inactive | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | |
6TP3 | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
daridorexant
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 3.0 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
7X2V | AGRF1 | ADGRF1 | ADGRF | B2 (Adhesion) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 10.1038/S41467-022-33173-4 | 2022-09-28 | |
4UG2 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Hi5 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 3 chems | 7.0-7.0 | 22°C |
CGS 21680
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 2.6 | Active | 10.1124/mol.114.097360 | 2015-04-08 | |
6UP7 | NTR1 | NTS1 | Neurotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
JMV431
gtoplig
chembl_ligand
pubchem
|
Agonist | 4.2 | Active | 10.1038/S41586-020-1953-1 | 2020-02-26 | |
5TUD | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monopalmitolein (9.7 MAG) | 6 chems | 7.7-7.7 | 20°C |
ergotamine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.0 | Active | 10.1073/PNAS.1700891114 | 2017-07-26 | |
6TOS | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL2413522
chembl_ligand
pubchem
|
Antagonist | 2.1 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-15 | |
6ME7 | MTR1B | MT2 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
2-phenylmelatonin
pubchem
|
Agonist | 3.2 | Inactive | 10.1038/S41586-019-1144-0 | 2019-04-24 | |
6PS0 | ADRB2 | β2 | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
carazolol
pubchem
gtoplig
chembl_ligand
drug_central
|
Antagonist | 3.4 | Inactive | 10.1107/S2052252519013137 | 2019-11-13 | |
4RWD | OPRD | δ | Opioid | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 6.0-6.0 | 20°C |
DIPP-NH2
|
Antagonist | 2.7 | Inactive | 10.1038/NSMB.2965 | 2015-01-14 | |
7JV5 | DRD1 | D1 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL1160787
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.CELL.2021.01.027 | 2021-02-24 | |
7YP7 | AGRG2 | ADGRG2 | ADGRG | B2 (Adhesion) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 2022-08-24 | ||
6M9T | PE2R3 | EP3 | Prostanoid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Misoprostol-FA
pubchem
|
Agonist | 2.5 | Active | 10.1038/S41589-018-0160-Y | 2018-12-05 | |
7CMV | DRD3 | D3 | Dopamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL70565
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 2.7 | Active | 10.1016/J.MOLCEL.2021.01.003 | 2021-03-10 | |
7S0F | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LEVISOPRENALINE
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1038/S41594-021-00679-2 | 2021-11-17 | |
5DSG | ACM4 | M4 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.5-8.0 | 20°C |
tiotropium
pubchem
gtoplig
chembl_ligand
drugbank
gtoplig
|
Antagonist | 2.6 | Inactive | 10.1038/NATURE17188 | 2016-03-16 | |
5K2B | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.0 | 20°C |
ZM-241385
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 2.5 | Inactive | 10.1126/SCIADV.1600292 | 2016-09-21 | |
4PXZ | P2Y12 | P2Y12 | P2Y | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 6 chemicals | 6 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.0-6.0 | 20°C |
2MeSADP
pubchem
gtoplig
chembl_ligand
gtoplig
|
Agonist | 2.5 | Intermediate | 10.1038/NATURE13288 | 2014-04-30 | |
6TPJ | OX2R | OX2 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
suvorexant
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Antagonist | 2.7 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | |
7TUY | GP183 | GPR183 | A orphans | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
8-[(2E)-3-(4-chlorop...
pubchem
|
Inverse agonist | 3.0 | Intermediate | 2022-04-13 | ||
6H7O | ADRB1 | β1 | Adrenoceptors | A (Rhodopsin) | Wild turkey | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(S)-Cyanopindolol
pubchem
|
Agonist | 2.8 | Active | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | |
6NBI | PTH1R | PTH1 | Parathyroid hormone | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Long-acting parathyr...
|
Agonist | 4.0 | Active | 10.1126/SCIENCE.AAV7942 | 2019-04-17 | |
5IU8 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Tni PRO (Trichoplusia ni) cell lines | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.5-5.5 | 20°C |
CHEMBL3934661
chembl_ligand
pubchem
|
Antagonist | 2.0 | Inactive | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | |
3RFM | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 1 chemicals | 1 steps | vapour diffusion | sitting drop | 6 chems | 8.0-8.8 | 4°C |
caffeine
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Antagonist | 3.6 | Inactive | 10.1016/J.STR.2011.06.014 | 2011-09-07 | ||
5VEX | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 5.0-5.8 | 20°C |
NNC0640
pubchem
gtoplig
|
NAM | 3.0 | Inactive | 10.1038/NATURE22378 | 2017-05-17 | |
4MQS | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 2 chemicals | 2 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 7.2-7.9 | 20°C |
iperoxo
pubchem
gtoplig
chembl_ligand
|
Agonist | 3.5 | Active | 10.1038/NATURE12735 | 2013-11-27 | |
6UVA | CALRL | calcitonin-like | Calcitonin | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
adrenomedullin 2/int...
gtoplig
|
Agonist | 2.3 | Active | 2020-04-01 | ||
7V9M | GHRHR | GHRH | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Somatoliberin
pubchem
|
Agonist | 3.3 | Active | 2021-10-20 | ||
8DU3 | AA2AR | A2A | Adenosine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
(4M)-6-bromo-4-(fura...
pubchem
|
Antagonist | 2.5 | Inactive | 10.1016/J.EJMECH.2022.114620 | 2022-08-10 | |
5LWE | CCR9 | CCR9 | Chemokine | A (Rhodopsin) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 5 chems | 7.9-8.0 | 20°C |
vercirnon
pubchem
gtoplig
chembl_ligand
drugbank
|
Allosteric antagonist | 2.8 | Inactive | 10.1038/NATURE20606 | 2016-12-07 | |
7U2K | OPRM | μ | Opioid | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
CHEMBL147044
chembl_ligand
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41586-022-05588-Y | 2022-12-07 | |
7XP5 | T2R46 | TAS2R46 | Taste 2 | T (Taste 2) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.1 | Active | 10.1126/SCIENCE.ABO1633 | 2022-10-12 | |
7LLY | GLP1R | GLP-1 | Glucagon | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Pro-glucagon
pubchem
|
Agonist | 3.3 | Active | 10.1038/S41467-021-27760-0 | 2022-01-12 | |
6IQL | DRD4 | D4 | Dopamine | A (Rhodopsin) | Mouse | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
L745870
pubchem
gtoplig
chembl_ligand
|
Antagonist | 3.5 | Inactive | 10.7554/ELIFE.48822 | 2019-12-04 | |
7BW0 | GPBAR | GPBA | Bile acid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 3.9 | Active | 10.1038/S41392-020-00262-Z | 2020-09-02 | |
2HPY | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drops | 5 chems | 5.9-6.1 | 283 K |
Retinal (all-trans)
pubchem
|
Agonist | 2.8 | Inactive | 10.1073/PNAS.0601765103 | 2006-08-22 | ||
4OO9 | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | Baculovirus | Sf21 | Insect | 1 chemicals | 1 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 4 chems | 6.8-6.8 | 20°C |
MAVOGLURANT
chembl_ligand
pubchem
|
NAM | 2.6 | Inactive | 10.1038/NATURE13396 | 2014-07-02 | |
8E3Z | VIPR1 | VPAC1 | VIP and PACAP | B1 (Secretin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Vasoactive intestina...
pubchem
|
Agonist | 2.7 | Active | 10.1038/S41467-022-34629-3 | 2022-11-23 | |
6DS0 | 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LY266097
pubchem
|
Antagonist | 3.2 | Intermediate | 10.1038/s41594-018-0116-7 | 2018-08-29 | |
6TOT | OX1R | OX1 | Orexin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
lemborexant
pubchem
gtoplig
chembl_ligand
drug_central
drugbank
|
Antagonist | 2.2 | Inactive | 10.1021/acs.jmedchem.9b01787 | 2020-01-15 | |
7W6P | ADA2A | α2A | Adrenoceptors | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
N-pyridin-4-ylisoqui...
pubchem
|
Agonist | 3.5 | Active | 10.1126/SCIENCE.ABN7065 | 2022-09-28 | |
5WIV | DRD4 | D4 | Dopamine | A (Rhodopsin) | Human | Baculovirus | Sf9 | Insect | 4 chemicals | 4 steps | in meso/LCP | lipidic cubic phase (LCP) | monoolein (9.9 MAG) | 6 chems | 5.9-6.2 | 20°C |
[3H]NEMONAPRIDE
chembl_ligand
pubchem
|
Antagonist | 2.1 | Inactive | 10.1126/SCIENCE.AAN5468 | 2017-10-18 | |
7XA3 | CCR2 | CCR2 | Chemokine | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
C-C motif chemokine ...
|
Agonist | 2.9 | Active | 10.1038/S41421-022-00403-4 | 2022-08-24 | |
5WKT | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | Native | Bovine | 1 chemicals | 1 steps | vapour diffusion | Hanging drop | 4 chems | 5.5-5.5 | 7-10°C |
B-Octylglucoside
pubchem
|
unknown | 3.2 | Active | 10.1038/NPROT.2017.135 | 2017-12-13 | ||
3C9M | OPSD | Rhodopsin | Opsins | A (Rhodopsin) | Bovine | NA | NA | NA | 1 chemicals | 1 steps | NA | NA | NA | 1 chems | 0.0-0.0 | NA |
Retinal (11-cis)
pubchem
|
Inverse agonist | 3.4 | Inactive | 10.1107/S0907444908017162 | 2008-08-05 | |
8F7S | OPRD | δ | Opioid | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
DELTORPHIN II
chembl_ligand
pubchem
|
Agonist | 3.0 | Active | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | |
7XJH | ADRB3 | β3 | Adrenoceptors | A (Rhodopsin) | Dog | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
LEVISOPRENALINE
chembl_ligand
chembl_ligand
pubchem
|
Agonist | 3.3 | Active | 2022-05-04 | ||
7JNI | AGTR2 | AT2 | Angiotensin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
olodanrigan
pubchem
gtoplig
chembl_ligand
drugbank
|
Antagonist | 3.0 | Active | 2022-02-09 | ||
7EPD | GRM2 | mGlu2 | Metabotropic glutamate | C (Glutamate) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
Apo (no ligand)
|
Apo (no ligand) | 3.9 | Inactive | 10.1038/S41586-021-03641-W | 2021-06-23 | |
6OIK | ACM2 | M2 | Acetylcholine (muscarinic) | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
iperoxo
pubchem
gtoplig
chembl_ligand
LY2119620 pubchem gtoplig chembl_ligand |
AgonistPAM | 3.6 | Active | 10.1126/SCIENCE.AAW5188 | 2019-05-08 | |
7PIU | MC4R | MC4 | Melanocortin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
setmelanotide
pubchem
gtoplig
drug_central
chembl_ligand
drugbank
|
Agonist | 2.6 | Active | 10.1038/S41422-021-00569-8 | 2021-11-17 | |
7VH0 | MTR1B | MT2 | Melatonin | A (Rhodopsin) | Human | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
ramelteon
pubchem
gtoplig
chembl_ligand
drugbank
drug_central
|
Agonist | 3.5 | Active | 2022-03-02 | ||
7FD8 | GRM5 | mGlu5 | Metabotropic glutamate | C (Glutamate) | Human | N/A |