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RECEPTOR EXPRESSION SOLUBILIZATION PURIFICATION STRUCTURE DETERMINATION
PDB pH Temp Resolution Reference Date
3AYM OPSD Rhodopsin Opsins A (Rhodopsin) Japanese flying squid NANativeSquid 1 chemicals 1 steps vapour diffusionsitting drop 5 chems 6.6-6.6 4°C Retinal pubchem
Agonist 2.8 Inactive 10.1016/J.JMB.2011.08.044 2011-08-17
6AQF AA2AR A2A Adenosine A (Rhodopsin) Human Pichia PastorisP. pastoris SMD1163Yeast 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.0-5.0 20°C ZM241385 pubchem
Antagonist 2.5 Inactive 10.1016/J.CELL.2017.12.004 2018-01-10
5YC8 ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N-methyl scopolamine pubchem
Antagonist 2.5 Inactive 10.1038/S41589-018-0152-Y 2018-11-21
4PXF OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionsitting drop 3 chems 6.0-6.0 4°C B-Octylglucoside pubchem
unknown 2.8 Active 10.1038/NCOMMS5801 2014-09-17
6KNM APJ apelin Apelin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Single domain antibo...
Agonist 3.2 Inactive 10.1126/SCIADV.AAX7379 2020-01-29
5JQH ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)7.7 MAG 5 chems 7.5-7.5 23°C Carazolol pubchem
Inverse agonist 3.2 Inactive 10.1038/NATURE18636 2016-07-13
6NBF PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Long-acting parathyr...
Agonist 3.0 Active 10.1126/SCIENCE.AAV7942 2019-04-17
4XNV P2RY1 P2Y1 P2Y A (Rhodopsin) Human BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.5-6.5 20°C BPTU pubchem
NAM 2.2 Intermediate 10.1038/NATURE14287 2015-04-01
6GT3 AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A AZD4635 pubchem
Antagonist 2.0 Inactive 2019-06-26
6CMO OPSD Rhodopsin Opsins A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps Cryo-EMFEI TITAN Krios microscope,Gatan K2 Summit direct electron camera,GIF-quantum energy filter (Gatan) 4 chems 7.2-7.2 4°C Apo (no ligand)
Apo (no ligand) 4.5 Active 10.1038/S41586-018-0215-Y 2018-06-20
2PED OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionHanging drop 5 chems 6.4-6.4 283 K Retinal pubchem
Inverse agonist 3.0 Inactive 10.1529/BIOPHYSJ.107.108225 2007-10-30
2YDO AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusHi5Insect 4 chemicals 4 steps vapour diffusionsitting drop 5 chems 7.6-7.6 4°C adenosine pubchem
Agonist 3.0 Active 10.1038/NATURE10136 2011-05-18
3VW7 PAR1 PAR1 Proteinase-activated A (Rhodopsin) Human BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.0-6.5 20°C Vorapaxar pubchem
Antagonist 2.2 Intermediate 10.1038/NATURE11701 2012-12-12
2R4R ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps vapour diffusionhanging drop 5 chems 6.5-7.5 22°C N/A N/A 3.4 Inactive 10.1038/NATURE06325 2007-11-06
3QAK AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.0-5.5 20°C UK-432097 pubchem
Agonist 2.7 Active 10.1126/SCIENCE.1202793 2011-03-09
2Y01 ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 1 chemicals 1 steps vapour diffusionsitting drops 6 chems 9.0-9.0 4°C Dobutamine pubchem
Agonist (partial) 2.6 Inactive 10.1038/NATURE09746 2011-03-30
6H7M ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Salbutamol pubchem
Agonist 2.8 Active 10.1126/SCIENCE.AAU5595 2018-10-17
5TE3 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionHanging drop 4 chems 5.2-6.6 4°C B-Octylglucoside pubchem
unknown 2.7 Active 10.1073/PNAS.1617446114 2017-03-15
3ZPQ ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 1 chemicals 1 steps vapour diffusionsitting drops 3 chems 9.0-9.0 4°C 4-(1-Piperazinyl)-1H... pubchem
Antagonist 2.8 Inactive 10.1021/JM400140Q 2013-04-03
1HZX OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 2 chemicals 2 steps vapour diffusionHanging drops 7 chems 6.0-6.0 4°C Retinal pubchem
Inverse agonist 2.8 Inactive 10.1021/BI0155091 2001-07-04
6I9K B1B1U5 Rhodopsin Opsins A (Rhodopsin) Hasarius adansoni N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Retinal pubchem
Inverse agonist 2.2 Inactive 10.1073/PNAS.1902192116 2019-07-03
6HLL NK1R NK1 Tachykinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CP-99,994 pubchem chembl_ligand
Antagonist 3.3 Inactive 10.1038/S41467-018-07939-8 2019-01-16
6E3Y CALRL calcitonin-like Calcitonin B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Calcitonin gene-rela... pubchem
Agonist 3.3 Active 10.1038/S41586-018-0535-Y 2018-09-19
6UOA GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (R)-(3-aminopropyl)m... pubchem chembl_ligand
Agonist 6.3 Active 10.1038/S41586-020-2408-4 2020-06-10
4UG2 AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusHi5Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 3 chems 7.0-7.0 22°C CGS-21680 pubchem
Agonist 2.6 Active 10.1124/MOL.114.097360 2015-04-08
6ZDR AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3-(4-Methyl-2-thiazo... pubchem
Antagonist 1.9 Inactive 10.1002/ANIE.202003788 2020-09-16
7JVQ DRD1 D1 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apomorphine pubchem chembl_ligand
Agonist 3.0 Active 10.1016/J.CELL.2021.01.027 2021-02-24
6WPW GLR glucagon Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Glucagon derivative ...
Agonist 3.1 Active 10.1126/SCIENCE.ABA3373 2020-08-12
5T04 NTR1 NTS1 Neurotensin A (Rhodopsin) Rat BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 8.5-9.0 20°C neurotensin pubchem chembl_ligand
Agonist 3.3 Active 10.1038/SREP38564 2016-12-21
4ZJC OX1R OX1 Orexin A (Rhodopsin) Human BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.6-5.6 20°C SB-674042 pubchem
Antagonist 2.8 Inactive 10.1038/NSMB.3183 2016-03-09
4DAJ ACM3 M3 Acetylcholine (muscarinic) A (Rhodopsin) Rat BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.5-7.5 22°C Tiotropium pubchem
Antagonist 3.4 Inactive 10.1038/NATURE10867 2012-02-22
4DKL OPRM μ Opioid A (Rhodopsin) Mouse BaculovirusSf9Insect 12 chemicals 12 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.0-7.0 20°C Methyl 4-[[(4R,4aS,7... pubchem
Antagonist 2.8 Inactive 10.1038/NATURE10954 2012-03-21
5DYS OPSD Rhodopsin Opsins A (Rhodopsin) Bovine Stable_cellsHEK293S-GnTI-Mammalian 1 chemicals 1 steps vapour diffusionSitting drop 4 chems 4.5-4.5 20°C Retinal pubchem
Agonist 2.3 Active 10.15252/EMBR.201642671 2016-08-10
7KNT CALRL calcitonin-like Calcitonin B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.2 Inactive 2021-02-24
6TPN OX2R OX2 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A HTL6641 pubchem chembl_ligand
Antagonist 2.6 Inactive 10.1021/ACS.JMEDCHEM.9B01787 2020-01-01
6OBA ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6-bromo-N~2~-phenylq... pubchem
(S)-Alprenolol pubchem
NAMAntagonist 3.1 Inactive 10.1038/S41589-020-0549-2 2020-03-25
5OLZ AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20°C 4-(3-amino-5-phenyl-... pubchem
Antagonist 1.9 Inactive 10.1038/S41598-017-18570-W 2018-01-17
4A4M OPSD Rhodopsin Opsins A (Rhodopsin) Bovine Stable_cellsHEK293TMammalian 1 chemicals 1 steps vapour diffusionsitting drop 3 chems 4.5-4.5 4°C Retinal pubchem
Agonist 3.3 Active 10.1073/PNAS.1114089108 2012-01-25
5VBL APJ apelin Apelin A (Rhodopsin) Human BaculovirusSf21Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 7 chems 6.1-6.1 20-22°C AMG3054
Agonist 2.6 Inactive 10.1016/J.STR.2017.04.008 2017-05-31
6NI3 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A BI-167107 pubchem
Agonist 3.8 Active 10.1038/S41594-019-0330-Y 2019-11-20
3ZPR ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 1 chemicals 1 steps vapour diffusionsitting drops 3 chems 9.0-9.0 4°C 4-Methyl-2-piperazin... pubchem
Antagonist 2.7 Inactive 10.1021/JM400140Q 2013-04-03
4ZUD AGTR1 AT1 Angiotensin A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.0-5.0 20°C Olmesartan
Inverse agonist 2.8 Inactive 10.1074/JBC.M115.689000 2015-10-07
6N51 GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Quisqualic acid pubchem
Agonist 4.0 Intermediate 10.1038/S41586-019-0881-4 2019-01-23
5ZKC ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N-methyl scopolamine pubchem
Antagonist 2.3 Inactive 10.1038/S41589-018-0152-Y 2018-11-21
4Z9G CRFR1 CRF1 Corticotropin-releasing factor B1 (Secretin) Human BaculovirusHi5Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 5.5-5.5 23°C CP-376395 pubchem
Antagonist 3.2 Inactive 10.2174/1874467210666170110114727 2016-06-29
5N2R AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20 PSB36 pubchem
Antagonist 2.8 Inactive 10.1016/J.STR.2017.06.012 2017-07-26
3AYN OPSD Rhodopsin Opsins A (Rhodopsin) Japanese flying squid NANativeSquid 1 chemicals 1 steps vapour diffusionsitting drop 5 chems 6.0-6.0 4°C Retinal pubchem
Inverse agonist 2.7 Inactive 10.1016/J.JMB.2011.08.044 2011-08-17
3UZC AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps vapour diffusionsitting drop 6 chems 8.0-8.0 4°C 4-(3-amino-5-phenyl-... pubchem
Antagonist 3.3 Inactive 10.1021/JM201376W 2012-03-21
7D7M PE2R4 EP4 Prostanoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Prostaglandin E2 pubchem chembl_ligand
Agonist 3.3 Active 2020-11-18
6X19 GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHU-128 pubchem
Agonist 2.1 Active 10.1101/2020.08.16.252585 2020-09-09
6LPJ AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ZM241385 pubchem
Antagonist 1.8 Inactive 10.1038/S41598-020-76277-X 2020-11-25
7CRH DRD1 D1 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1H-3-Benzazepine-7,8... pubchem chembl_ligand
Agonist 3.3 Active 10.1016/J.CELL.2021.01.028 2021-03-03
5C1M OPRM μ Opioid A (Rhodopsin) Mouse BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 7 chems 7.5-7.5 20°C GTPL9363 pubchem
Agonist 2.1 Active 10.1038/NATURE14886 2015-08-05
6LPB PACR PAC1 VIP and PACAP B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PACAP pubchem
Agonist 3.9 Active 10.1038/S41594-020-0386-8 2020-03-11
6TPK OXYR OT Vasopressin and oxytocin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Retosiban pubchem
Antagonist 3.2 Inactive 10.1126/SCIADV.ABB5419 2020-08-05
5K2D AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.0-5.0 20°C ZM241385 pubchem
Antagonist 1.9 Inactive 10.1126/SCIADV.1600292 2016-09-21
4LDO ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)7.7 MAG 5 chems 6.5-6.5 20°C Epinephrine pubchem
Agonist 3.2 Active 10.1038/NATURE12572 2013-09-25
6QNO OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Retinal pubchem
Agonist 4.4 Active 10.7554/ELIFE.46041 2019-07-10
5VAI G1SGD4 GLP-1 Glucagon B1 (Secretin) Rabbit BaculovirusSf9Insect 6 chemicals 6 steps Cryo-EMFEI, glow-discharged holey carbon grids 7 chems 7.5-7.5 20°C GLP-1
Agonist 4.1 Active 10.1038/NATURE22394 2017-05-24
4U16 ACM3 M3 Acetylcholine (muscarinic) A (Rhodopsin) Rat BaculovirusSf9Insect 9 chemicals 9 steps sponge mesophaselipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.5-7.5 298 K N-methyl scopolamine pubchem
Antagonist 3.7 Inactive 10.1016/J.STR.2014.08.022 2014-11-26
6OIJ ACM1 M1 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Iperoxo pubchem
Agonist 3.3 Active 10.1126/SCIENCE.AAW5188 2019-05-08
2G87 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 6.5-7.5 283 K Retinal pubchem
Agonist 2.6 Inactive 10.1002/ANIE.200600595 2006-09-02
4YAY AGTR1 AT1 Angiotensin A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 6 chems 5.0-6.0 20°C ZD7155 pubchem
Antagonist 2.9 Inactive 10.1016/J.CELL.2015.04.011 2015-04-22
6N48 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2-[[(3R)-4-(4-Tert-b... pubchem
BI-167107 pubchem
PAMAgonist 3.2 Active 10.1126/SCIENCE.AAW8981 2019-06-26
6ZDV AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2-Methyl-3-(4-methyl... pubchem
Antagonist 2.1 Inactive 10.1002/ANIE.202003788 2020-09-16
5X93 EDNRB ETB Endothelin A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.0-7.0 20°C K-8794 pubchem
Antagonist 2.2 Inactive 10.1038/NSMB.3450 2017-08-16
4GRV NTR1 NTS1 Neurotensin A (Rhodopsin) Rat BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.0-7.0 20°C Neurotensin (8-13) pubchem
Agonist 2.8 Active 10.1038/NATURE11558 2012-10-17
2I36 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 2 chemicals 2 steps vapour diffusionsitting drops 5 chems 7.0-8.0 5°C Apo (no ligand)
Apo (no ligand) 4.1 Inactive 10.1073/PNAS.0608022103 2006-10-17
6TQ7 OX1R OX1 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SB-334867 pubchem chembl_ligand
Antagonist 2.7 Inactive 10.1021/ACS.JMEDCHEM.9B01787 2020-01-01
7D3S SCTR secretin Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A secretin
Agonist 2.9 Active 10.1016/J.BBRC.2020.08.042 2020-11-04
6KPF CNR2 CB2 Cannabinoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (6Ar,9R,10aR)-9-(hyd... pubchem
Agonist 2.9 Active 10.1016/J.CELL.2020.01.008 2020-02-12
4ZWJ OPSD Rhodopsin Opsins A (Rhodopsin) Human Transient_transfectionHEK293S(TetR)-GnTI-Mammalian 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monopalmitolein (9.7 MAG) 5 chems 5.0-5.0 20°C Apo (no ligand)
Apo (no ligand) 3.3 Active 10.1038/NATURE14656 2015-07-29
4GBR ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 6.5-6.5 20°C Carazolol pubchem
Inverse agonist 4.0 Inactive 10.1371/JOURNAL.PONE.0046039 2012-10-24
3C9L OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANANA 1 chemicals 1 steps NANANA 1 chems 0.0-0.0 NA Retinal pubchem
Inverse agonist 2.7 Inactive 10.1107/S0907444908017162 2008-08-05
5TGZ CNR1 CB1 Cannabinoid A (Rhodopsin) Human Transient_transfectionHEK293FMammalian 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.0-7.4 20°C AM-6538 pubchem
Antagonist 2.8 Inactive 10.1016/J.CELL.2016.10.004 2016-11-02
7LJC DRD1 D1 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Mevidalen pubchem
743408-71-1 pubchem chembl_ligand
PAMAgonist 3.0 Active 10.1101/2021.02.07.430101 2021-03-03
7CMU DRD3 D3 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Pramipexole pubchem
Agonist 3.0 Active 10.1016/J.MOLCEL.2021.01.003 2021-03-10
4NTJ P2Y12 P2Y12 P2Y A (Rhodopsin) Human BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.0-6.5 20°C AZD1283 pubchem
Antagonist 2.6 Intermediate 10.1038/NATURE13083 2014-03-26
4BV0 NTR1 NTS1 Neurotensin A (Rhodopsin) Rat NAE. coli BL21(DE3)Bacteria 3 chemicals 3 steps vapour diffusionsitting drops 5 chems 9.4-9.4 4°C neurotensin pubchem chembl_ligand
Agonist 3.1 Inactive 10.1073/PNAS.1317903111 2014-01-29
6ME9 MTR1B MT2 Melatonin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Ramelteon pubchem chembl_ligand
Agonist 3.3 Inactive 10.1038/S41586-019-1144-0 2019-04-24
3OAX OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 6.0-6.0 283 K Retinal pubchem
Inverse agonist 2.6 Inactive 10.1016/J.BPJ.2010.08.003 2011-01-19
2VT4 ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 2 chemicals 2 steps vapour diffusionhanging drop 4 chems 6.9-7.3 18°C (S)-Cyanopindolol pubchem
Antagonist 2.7 Inactive 10.1038/NATURE07101 2008-06-24
7KNU CALRL calcitonin-like Calcitonin B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Calcitonin gene-rela... pubchem
Agonist 3.5 Inactive 10.1126/SCIENCE.ABF7258 2021-02-24
6W2X GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CGP55845 pubchem
1-Stearoyl-2-oleoyl-... pubchem
Inverse agonistNAM 3.6 Active 10.1038/S41586-020-2469-4 2020-07-01
6M1I PACR PAC1 VIP and PACAP B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PACAP pubchem
Agonist 3.5 Active 10.1038/S41422-020-0280-2 2020-03-11
6UUS CALRL calcitonin-like Calcitonin B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A adrenomedullin
Agonist 2.4 Active 10.1021/ACSPTSCI.9B00080 2020-04-01
6C1Q C5AR1 C5a1 Complement peptide A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 6.5-6.5 10°C PMX53 pubchem chembl_ligand
NDT 9513727 pubchem
AntagonistNAM 2.9 Inactive 10.1038/S41594-018-0067-Z 2018-05-30
7K15 LT4R1 BLT1 Leukotriene A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N-(tert-butylsulfony... pubchem
Antagonist 2.9 Inactive 2021-02-17
6WIV GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (2R)-3-{[(S)-(2-amin... pubchem
[(2R)-3-[(Z)-icos-11... pubchem
NAMNAM 3.3 Active 10.1038/S41586-020-2452-0 2020-07-01
4N6H OPRD δ Opioid A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 7 chems 6.1-6.2 20-23°C Naltrindole pubchem
Antagonist 1.8 Inactive 10.1038/NATURE12944 2013-12-25
6PWC NTR1 NTS1 Neurotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A neurotensin pubchem chembl_ligand
Agonist 4.9 Active 10.1038/S41422-019-0256-2 2019-12-04
7D76 AGRG3 ADGRG3 ADGRG B2 (Adhesion) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Beclomethasone pubchem
Agonist 3.1 Active 10.1038/S41586-020-03083-W 2021-02-03
4IAQ 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 8.7-8.7 20°C Dihydroergotamine pubchem
Agonist 2.8 Inactive 10.1126/SCIENCE.1232807 2013-03-13
4GPO ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 3.6-4.0 18°C N/A N/A 3.5 Inactive 10.1038/NSMB.2504 2013-02-27
6UO8 GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N~4~,N~6~-dicyclopen... pubchem
(R)-(3-aminopropyl)m... pubchem chembl_ligand
PAMAgonist 3.6 Active 10.1038/S41586-020-2408-4 2020-06-10
5XSZ Q08BG4 LPA6 Lysophospholipid (LPA) A (Rhodopsin) Zebrafish BaculovirusSf9Insect 8 chemicals 8 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 6 chems 6.0-6.0 20°C N/A N/A 3.2 Intermediate 10.1038/NATURE23448 2017-08-16
6LML GLR glucagon Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A glucagon pubchem
Agonist 3.9 Active 10.1126/SCIENCE.AAZ5346 2020-04-01
5IU7 AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20°C 2-(Furan-2-yl)-5-N-[... pubchem
Antagonist 1.9 Inactive 10.1021/ACS.JMEDCHEM.6B00653 2016-06-29
5ZHP ACM3 M3 Acetylcholine (muscarinic) A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (1R,2R,4S,5S,7s)-7-(... pubchem
Antagonist 3.1 Inactive 10.1073/PNAS.1813988115 2018-11-28
4JKV SMO SMO Frizzled F (Frizzled) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 6 chems 7.4-7.4 20°C Taladegib pubchem
Antagonist 2.5 Inactive 10.1038/NATURE12167 2013-04-24
4XES NTR1 NTS1 Neurotensin A (Rhodopsin) Rat BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.0-7.4 20°C neurotensin pubchem chembl_ligand
Agonist 2.6 Active 10.1038/NCOMMS8895 2015-07-29
5YHL PE2R4 EP4 Prostanoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ONO-AE3-208-Br pubchem
Antagonist 4.2 Inactive 10.1038/S41589-018-0131-3 2018-12-05
5CXV ACM1 M1 Acetylcholine (muscarinic) A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 8.0-8.0 20°C Tiotropium pubchem
Antagonist 2.7 Inactive 10.1038/NATURE17188 2016-03-09
7CA5 GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 7.6 Intermediate 10.1016/J.JMB.2020.09.023 2020-11-11
6E59 NK1R NK1 Tachykinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A L760735 pubchem
Antagonist 3.4 Inactive 10.1073/PNAS.1812717115 2018-12-12
5MZJ AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20 Theophylline pubchem
Antagonist 2.0 Inactive 10.1016/J.STR.2017.06.012 2017-07-26
6ORV GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A TT-OAD2 pubchem
Agonist 3.0 Active 10.1038/s41586-019-1902-z 2020-01-08
7CFM GPBAR GPBA Bile acid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A P395 pubchem chembl_ligand
Agonist 3.0 Active 10.1038/S41586-020-2569-1 2020-09-09
4RWD OPRD δ Opioid A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.0-6.0 20°C DIPP-NH2
Antagonist 2.7 Inactive 10.1038/NSMB.2965 2015-01-14
7DTT CASR CaS Calcium-sensing C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Calcium ion pubchem
Agonist 3.8 Inactive 10.1038/S41422-021-00474-0 2021-03-10
6PS7 AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ZM241385 pubchem
Antagonist 1.9 Inactive 10.1107/S2052252519013137 2019-11-13
4XT1 US28 US28 Unclassified A (Rhodopsin) strain AD169 BaculovirusHEK293S(TetR)-GnTI-Mammalian 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 7 chems 6.3-7.0 20°C Fractalkine
Agonist (partial) 2.9 Active 10.1126/SCIENCE.AAA5026 2015-03-04
5XEZ GLR glucagon Glucagon B1 (Secretin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.0-7.0 20°C NNC0640 pubchem
NAM 3.0 Inactive 10.1038/NATURE22363 2017-05-24
6PS6 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Timolol pubchem
Antagonist 2.7 Inactive 10.1107/S2052252519013137 2019-11-13
5WF5 AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.0-5.0 20°C UK-432097 pubchem
Agonist 2.6 Active 10.1016/J.STR.2017.12.013 2018-02-21
5TZR FFAR1 FFA1 Free fatty acid A (Rhodopsin) Human BaculovirusSf21Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.7-8.3 20°C MK-8666 pubchem
Agonist 2.2 Intermediate 10.1038/NSMB.3417 2017-06-07
6TP4 OX1R OX1 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ACT-462206 pubchem chembl_ligand
Antagonist 3.0 Inactive 10.1021/ACS.JMEDCHEM.9B01787 2020-01-01
3PWH AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps vapour diffusionsitting drop 6 chems 8.0-8.8 4°C ZM241385 pubchem
Antagonist 3.3 Inactive 10.1016/J.STR.2011.06.014 2011-09-07
5VRA AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 7 chems 4.6-5.0 20°C ZM241385 pubchem
Antagonist 2.4 Inactive 10.1038/NPROT.2017.135 2017-12-13
6TOT OX1R OX1 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Lemborexant pubchem chembl_ligand
Antagonist 2.2 Inactive 10.1021/ACS.JMEDCHEM.9B01787 2020-01-15
6H7J ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Isoprenaline pubchem
Agonist 2.8 Active 10.1126/SCIENCE.AAU5595 2018-10-17
6OS2 AGTR1 AT1 Angiotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A TRV026
Agonist 2.7 Active 10.1126/SCIENCE.AAY9813 2020-02-19
6PS0 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Carazolol pubchem
Antagonist 3.4 Inactive 10.1107/S2052252519013137 2019-11-13
3VG9 AA2AR A2A Adenosine A (Rhodopsin) Human P.pastorisP. pastoris SMD1163Yeast 2 chemicals 2 steps vapour diffusionhanging drop 4 chems 6.5-6.5 20°C ZM241385 pubchem
Antagonist 2.7 Inactive 10.1038/NATURE10750 2012-02-01
6VMS DRD2 D2 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Bromocriptine pubchem
Agonist 3.8 Active 10.1038/S41586-020-2379-5 2020-06-17
6PB0 CRFR1 CRF1 Corticotropin-releasing factor B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Urocortin pubchem chembl_ligand
Agonist 3.0 Active 10.1016/J.MOLCEL.2020.01.013 2020-02-12
5WS3 OX2R OX2 Orexin A (Rhodopsin) Human BaculovirusSf9Insect 9 chemicals 9 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 5.8-6.2 20°C EMPA pubchem chembl_ligand
Antagonist 2.3 Inactive 10.1016/J.STR.2017.11.005 2017-12-13
5UIG AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps vapour diffusionSitting drop 6 chems 7.0-7.0 20°C 5-Amino-N-[(2-Methox... pubchem
Antagonist 3.5 Inactive 10.1073/PNAS.1621423114 2017-02-08
5XF1 GLR glucagon Glucagon B1 (Secretin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.0-7.0 20°C NNC0640 pubchem
NAM 3.2 Inactive 10.1038/NATURE22363 2017-05-24
3OE8 CXCR4 CXCR4 Chemokine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 6.0-6.0 20°C IT1t pubchem
Antagonist 3.1 Inactive 10.1126/SCIENCE.1194396 2010-10-27
4BUO NTR1 NTS1 Neurotensin A (Rhodopsin) Rat NAE. coli BL21(DE3)Bacteria 6 chemicals 6 steps vapour diffusionSitting drop 5 chems 9.4-9.4 4°C neurotensin pubchem chembl_ligand
Agonist 2.8 Inactive 10.1073/PNAS.1317903111 2014-01-29
5K2A AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.0-5.0 20°C ZM241385 pubchem
Antagonist 2.5 Inactive 10.1126/SCIADV.1600292 2016-09-21
5V54 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 7 chems 7.0-7.0 20°C CHEMBL428892 pubchem chembl_ligand
Antagonist 3.9 Inactive 2018-02-07
7D77 AGRG3 ADGRG3 ADGRG B2 (Adhesion) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Hydrocortisone pubchem
Agonist 2.9 Active 10.1038/S41586-020-03083-W 2021-02-03
6VJM GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 4.0 Active 10.1038/S41586-020-2408-4 2020-06-10
5DHG OPRX NOP Opioid A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.4-6.4 20°C C-35 pubchem
Antagonist 3.0 Inactive 10.1016/J.STR.2015.07.024 2015-10-21
4XEE NTR1 NTS1 Neurotensin A (Rhodopsin) Rat BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.0-8.0 20°C neurotensin pubchem chembl_ligand
Agonist 2.9 Active 10.1038/NCOMMS8895 2015-07-29
4XNW P2RY1 P2Y1 P2Y A (Rhodopsin) Human BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.0-8.0 20°C MRS2500 pubchem
Antagonist 2.7 Intermediate 10.1038/NATURE14287 2015-04-01
4PHU FFAR1 FFA1 Free fatty acid A (Rhodopsin) Human BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.6-7.6 20°C Fasiglifam pubchem
Agonist 2.3 Intermediate 10.1038/NATURE13494 2014-07-16
5L7I SMO SMO Frizzled F (Frizzled) Human Transient_transfectionHEK293S(TetR)-GnTI-Mammalian 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 8 chems 6.0-6.0 20°C Vismodegib pubchem
Antagonist 3.3 Inactive 10.1038/NATURE18934 2016-07-20
3NY8 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.5-8.0 20°C ICI-118551 pubchem
Inverse agonist 2.8 Inactive 10.1021/JA105108Q 2010-08-11
6PT0 CNR2 CB2 Cannabinoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Win 55212-2 pubchem chembl_ligand
Agonist 3.2 Active 10.1016/J.CELL.2020.01.007 2020-02-12
4XT3 US28 US28 Unclassified A (Rhodopsin) strain AD169 BaculovirusHEK293S(TetR)-GnTI-Mammalian 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monovaccenin(11.7 MAG) 6 chems 7.4-7.4 20°C Fractalkine
Agonist (partial) 3.8 Active 10.1126/SCIENCE.AAA5026 2015-03-04
6MH8 AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ZM241385 pubchem
Antagonist 4.2 Inactive 10.1107/S205225251900263X 2019-04-24
6JOD AGTR2 AT2 Angiotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A angiotensin II pubchem chembl_ligand
Agonist 3.2 Active 10.1016/J.STR.2019.12.003 2020-01-15
6G79 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps Cryo-EMVolta phase plate, Falcon III detector (FEI Titan Krios, 300kV) 5 chems 7.5-7.5 4°C Donitriptan pubchem
Agonist 3.8 Active 10.1038/S41586-018-0241-9 2018-06-20
6KPG CNR1 CB1 Cannabinoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (6Ar,9R,10aR)-9-(hyd... pubchem
Agonist 3.0 Active 10.1016/J.CELL.2020.01.008 2020-02-12
2Y02 ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 1 chemicals 1 steps vapour diffusionsitting drops 6 chems 9.0-9.0 4°C Carmoterol pubchem
Agonist 2.6 Inactive 10.1038/NATURE09746 2011-01-12
7C6A AGTR2 AT2 Angiotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (Sar1,Ile8)-Angioten... pubchem chembl_ligand
Agonist 3.4 Active 10.1038/S41598-020-68355-X 2020-07-29
3RZE HRH1 H1 Histamine A (Rhodopsin) Human Pichia PastorisP. pastoris SMD1163Yeast 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 4.5-4.5 20-22°C Doxepin pubchem
Antagonist 3.1 Inactive 10.1038/NATURE10236 2011-06-15
3PXO OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionHanging drops 3 chems 5.0-5.8 4°C Retinal pubchem
Agonist 3.0 Active 10.1038/NATURE09789 2011-03-09
6V9S OX1R OX1 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A JH112 pubchem
Antagonist 3.5 Inactive 10.1073/PNAS.2002704117 2020-07-15
6AKY CCR5 CCR5 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4,4-difluoro-N-[(1S)...
Antagonist 2.8 Inactive 10.1021/ACS.JMEDCHEM.8B01077 2018-10-24
6TOD OX1R OX1 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A EMPA pubchem chembl_ligand
Antagonist 2.1 Inactive 10.1021/ACS.JMEDCHEM.9B01787 2020-01-01
6LMK GLR glucagon Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A glucagon pubchem
Agonist 3.7 Active 10.1126/SCIENCE.AAZ5346 2020-04-01
4Z35 LPAR1 LPA1 Lysophospholipid (LPA) A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.5-5.5 20°C ONO-9910539 pubchem
Antagonist 2.9 Inactive 10.1016/J.CELL.2015.06.002 2015-06-03
6FKC OPSD Rhodopsin Opsins A (Rhodopsin) Bovine BaculovirusHEK293S(TetR)-GnTI-Mammalian 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 4.5-4.5 20°C 3-[1'-[(2~{S})-2-(4-... pubchem
Agonist 2.5 Active 10.1073/PNAS.1718084115 2018-04-04
6LPL AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ZM241385 pubchem
Antagonist 2.0 Inactive 10.1038/S41598-020-76277-X 2020-11-25
5WIU DRD4 D4 Dopamine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 5 chems 5.8-6.2 20°C Nemonapride pubchem
Antagonist 2.0 Inactive 10.1126/SCIENCE.AAN5468 2017-10-18
6TP6 OX1R OX1 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Filorexant pubchem chembl_ligand
Antagonist 2.3 Inactive 10.1021/ACS.JMEDCHEM.9B01787 2020-01-01
6OS0 AGTR1 AT1 Angiotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Angiotensinogen pubchem
Agonist 2.9 Active 10.1126/SCIENCE.AAY9813 2020-02-19
6OFJ OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 4.5 Inactive 10.1074/JBC.RA119.010089 2019-08-21
6KK1 GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PF-06372222 pubchem
NAM 2.8 Inactive 10.1107/S2052252519013496 2019-11-13
3EML AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.5-6.5 20°C ZM241385 pubchem
Antagonist 2.6 Inactive 10.1126/SCIENCE.1164772 2008-10-14
6WW2 FZD5 FZD5 Frizzled F (Frizzled) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.7 Inactive 10.7554/ELIFE.58464 2020-08-19
5T1A CCR2 CCR2 Chemokine A (Rhodopsin) Human BaculovirusSf21Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 5 chems 6.5-6.5 20 °C. GTPL9431 pubchem
BMS-681 pubchem
Allosteric antagonistAntagonist 2.8 Inactive 10.1038/NATURE20605 2016-12-14
6WH4 5HT2A 5-HT2A 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL428892 pubchem chembl_ligand
Inverse agonist 3.4 Inactive 10.1016/J.CELL.2020.08.024 2020-09-23
5NM4 AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 5 chems 5.0-5.0 20°C ZM241385 pubchem
Antagonist 1.7 Inactive 10.1038/S41467-017-00630-4 2017-09-27
5NJ6 PAR2 PAR2 Proteinase-activated A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 7 chems 5.5-6.2 20°C N/A N/A 4.0 Intermediate 10.1038/NATURE22309 2017-05-03
6IGK EDNRB ETB Endothelin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A endothelin-3 pubchem
Agonist 2.0 Inactive 10.1038/S41467-018-07094-0 2018-11-21
4K5Y CRFR1 CRF1 Corticotropin-releasing factor B1 (Secretin) Human BaculovirusHi5Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 5.5-5.5 22.5°C CP-376395 pubchem
Antagonist 3.0 Inactive 10.1038/NATURE12357 2013-07-17
3P0G ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 8.0-8.0 20°C BI-167107 pubchem
Agonist 3.5 Active 10.1038/NATURE09648 2011-01-19
5CGD GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human BaculovirusSf21Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 5.5-6.8 20°C Q27455393 pubchem
NAM 2.6 Inactive 10.1021/ACS.JMEDCHEM.5B00892 2015-08-12
3PQR OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionHanging drops 3 chems 5.6-5.6 4°C Retinal pubchem
Agonist 2.9 Active 10.1038/NATURE09789 2011-03-09
4WW3 OPSD Rhodopsin Opsins A (Rhodopsin) Japanese flying squid NANativeSquid 1 chemicals 1 steps vapour diffusionsitting drop 4 chems 6.4-6.4 100-170 K Retinal pubchem
Agonist 2.8 Inactive 10.1371/JOURNAL.PONE.0126970 2015-06-17
4EJ4 OPRD δ Opioid A (Rhodopsin) Mouse BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.5-7.5 20°C Naltrindole pubchem
Antagonist 3.4 Inactive 10.1038/NATURE11111 2012-05-16
4OO9 GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human BaculovirusSf21Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 6.8-6.8 20°C Mavoglurant pubchem
NAM 2.6 Inactive 10.1038/NATURE13396 2014-07-02
6FJ3 PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ePTH
Agonist (partial) 2.5 Inactive 10.1038/S41594-018-0151-4 2018-11-21
4QIN SMO SMO Frizzled F (Frizzled) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 6 chems 7.2-7.2 20°C SAG1.5 pubchem
Agonist 2.6 Inactive 10.1038/NCOMMS5355 2014-07-23
4EIY AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.0-5.0 20°C ZM241385 pubchem
Antagonist 1.8 Inactive 10.1126/SCIENCE.1219218 2012-07-25
4MQT ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.2-7.9 20°C 2CU pubchem
Iperoxo pubchem
PAMAgonist 3.7 Active 10.1038/NATURE12735 2013-11-27
5G53 AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps vapour diffusionSitting drop 6 chems 5.7-5.7 4°C NECA pubchem
Agonist 3.4 Active 10.1038/NATURE18966 2016-08-03
3KJ6 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 3 chemicals 3 steps vapour diffusionbicelles 5 chems 7.5-7.5 298K N/A N/A 3.4 Inactive 10.1038/NATURE08650 2010-02-16
6RZ6 CLTR2 CysLT2 Leukotriene A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ONO-2570366 (C2221 s... pubchem
Antagonist 2.4 Intermediate 10.1038/S41467-019-13348-2 2019-12-11
4U14 ACM3 M3 Acetylcholine (muscarinic) A (Rhodopsin) Rat BaculovirusSf9Insect 9 chemicals 9 steps sponge mesophaselipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 8.1-8.1 298 K Tiotropium pubchem
Antagonist 3.6 Inactive 10.1016/J.STR.2014.08.022 2014-11-26
6PH7 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Nerol pubchem
unknown 2.9 Active 2020-07-01
6FK9 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine BaculovirusHEK293S(TetR)-GnTI-Mammalian 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 4.5-4.5 20°C (2~{S})-3-methyl-2-p... pubchem
Agonist 2.6 Active 10.1073/PNAS.1718084115 2018-04-04
6FUF OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Retinal pubchem
Agonist 3.1 Active 10.1126/SCIADV.AAT7052 2018-10-03
4IAR 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.5-7.5 20°C Ergotamine pubchem
Agonist 2.7 Inactive 10.1126/SCIENCE.1232807 2013-03-13
6UUN CALRL calcitonin-like Calcitonin B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A adrenomedullin
Agonist 3.0 Active 10.1021/ACSPTSCI.9B00080 2020-03-25
7JVP DRD1 D1 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 39YLC3L0ZU pubchem
Agonist 2.9 Active 10.1016/J.CELL.2021.01.027 2021-02-24
5XPR EDNRB ETB Endothelin A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.0-7.0 20°C N/A N/A 3.6 Inactive 10.1038/NSMB.3450 2017-08-16
6C1R C5AR1 C5a1 Complement peptide A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 6.5-6.5 10°C PMX53 pubchem chembl_ligand
Avacopan pubchem
AntagonistNAM 2.2 Inactive 10.1038/S41594-018-0067-Z 2018-05-30
6O3C SMO SMO Frizzled F (Frizzled) Mouse N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SAG21k pubchem
Agonist 2.8 Active 10.1038/S41586-019-1355-4 2019-07-03
5UNH AGTR2 AT2 Angiotensin A (Rhodopsin) Human BaculovirusSf21Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 7 chems 8.0-8.0 20°C N-[(Furan-2-Yl)methy... pubchem
Antagonist 2.9 Active 10.1038/NATURE22035 2017-04-05
7CKY DRD1 D1 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6-[4-[3-(Difluoromet... pubchem chembl_ligand
Agonist 3.2 Active 10.1016/J.CELL.2021.01.028 2021-03-03
6FKA OPSD Rhodopsin Opsins A (Rhodopsin) Bovine BaculovirusHEK293S(TetR)-GnTI-Mammalian 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 4.5-4.5 20°C (2~{S})-2-(3,4-dichl... pubchem
Agonist 2.7 Active 10.1073/PNAS.1718084115 2018-04-04
7DHR ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Isoprenaline pubchem
Agonist 3.8 Active 10.1093/NSR/NWAA284 2020-12-16
6TO7 OX1R OX1 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Suvorexant pubchem
Antagonist 2.3 Inactive 10.1021/ACS.JMEDCHEM.9B01787 2020-01-01
7LJD DRD1 D1 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Mevidalen pubchem
dopamine pubchem
PAMAgonist 3.2 Active 10.1101/2021.02.07.430101 2021-03-03
6N52 GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.0 Inactive 10.1038/S41586-019-0881-4 2019-01-23
6OT0 SMO SMO Frizzled F (Frizzled) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 24,25-Epoxy-choleste... pubchem
Agonist 3.9 Active 10.1038/S41586-019-1286-0 2019-06-12
4ZJ8 OX1R OX1 Orexin A (Rhodopsin) Human BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.4-5.4 20°C Suvorexant pubchem
Antagonist 2.8 Inactive 10.1038/NSMB.3183 2016-03-09
6NBH PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Long-acting parathyr...
Agonist 3.5 Active 10.1126/SCIENCE.AAV7942 2019-04-17
5ZTY CNR2 CB2 Cannabinoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A AM10257 pubchem
Antagonist 2.8 Inactive 10.1016/J.CELL.2018.12.011 2019-01-30
6PGS OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Geraniol pubchem
unknown 2.9 Active 2020-07-01
6NIY CALCR CT Calcitonin B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A calcitonin
Agonist 3.3 Active 10.1021/ACSPTSCI.8B00056 2019-01-23
6TQ4 OX1R OX1 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2-[1-(phenylsulfonyl... pubchem
Antagonist 2.3 Inactive 10.1021/ACS.JMEDCHEM.9B01787 2020-01-01
4O9R SMO SMO Frizzled F (Frizzled) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 5 chems 7.4-7.4 20°C Cyclopamine pubchem
Antagonist 3.2 Inactive 10.1038/NCOMMS4309 2014-03-05
6RZ8 CLTR2 CysLT2 Leukotriene A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ONO-2080365 pubchem
Antagonist 2.7 Intermediate 10.1038/S41467-019-13348-2 2019-12-11
5WKT OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionHanging drop 4 chems 5.5-5.5 7-10°C B-Octylglucoside pubchem
unknown 3.2 Active 10.1038/NPROT.2017.135 2017-12-13
6TOS OX1R OX1 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GSK1059865 pubchem chembl_ligand
Antagonist 2.1 Inactive 10.1021/ACS.JMEDCHEM.9B01787 2020-01-15
3NYA ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.0-7.0 21-23°C (S)-Alprenolol pubchem
Antagonist 3.2 Inactive 10.1021/JA105108Q 2010-08-11
6ME6 MTR1B MT2 Melatonin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2-phenylmelatonin pubchem
Agonist 2.8 Inactive 10.1038/S41586-019-1144-0 2019-04-24
6E67 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A BI-167107 pubchem
Agonist 3.7 Active 10.1016/J.CELL.2019.04.021 2019-06-05
4N4W SMO SMO Frizzled F (Frizzled) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 7 chems 6.9-6.9 20°C Sant-1 pubchem
Antagonist 2.8 Inactive 10.1038/NCOMMS5355 2014-01-22
6W2Y GABR1 GABAB1 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CGP55845 pubchem
1-Stearoyl-2-oleoyl-... pubchem
Inverse agonistNAM 3.2 Active 10.1038/S41586-020-2469-4 2020-07-01
4L6R GLR glucagon Glucagon B1 (Secretin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.0-7.0 20°C N/A N/A 3.3 Inactive 10.1038/NATURE12393 2013-07-24
6DRZ 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Methysergide pubchem
Antagonist 3.1 Intermediate 10.1038/S41594-018-0116-7 2018-08-29
6B3J GLP1R GLP-1 Glucagon B1 (Secretin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 2 chemicals 2 steps Cryo-EMVolta phase plate (FEI) 5 chems 7.4-7.4 4°C Exendin-P5
Agonist 3.3 Active 10.1038/NATURE25773 2018-02-21
5JTB AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.0-5.0 20°C ZM241385 pubchem
Antagonist 2.8 Inactive 10.1126/SCIADV.1602952 2017-05-31
6OS1 AGTR1 AT1 Angiotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A TRV023
Agonist 2.8 Active 10.1126/SCIENCE.AAY9813 2020-02-19
6N4B CNR1 CB1 Cannabinoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Fub-mdmb pubchem
Agonist 3.0 Active 10.1016/J.CELL.2018.11.040 2019-01-30
6TP3 OX1R OX1 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Nemorexant pubchem
Antagonist 3.0 Inactive 10.1021/ACS.JMEDCHEM.9B01787 2020-01-01
7LCI GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PF-06882961 pubchem
Agonist 2.9 Active 2021-01-20
3PBL DRD3 D3 Dopamine A (Rhodopsin) Human BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.5-7.5 20°C Eticlopride pubchem
Antagonist 2.9 Inactive 10.1126/SCIENCE.1197410 2010-11-03
5TZY FFAR1 FFA1 Free fatty acid A (Rhodopsin) Human BaculovirusSf21Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.3-6.8 20°C MK-8666 pubchem
(2S,3R)-3-Cyclopropy... pubchem
AgonistPAM 3.2 Intermediate 10.1038/NSMB.3417 2017-06-07
6ME2 MTR1A MT1 Melatonin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Ramelteon pubchem chembl_ligand
Agonist 2.8 Inactive 10.1038/S41586-019-1141-3 2019-04-24
7DTW CASR CaS Calcium-sensing C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 4.5 Inactive 10.1038/S41422-021-00474-0 2021-03-10
6GPX CCR2 CCR2 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A MK-0812 pubchem
Antagonist 2.7 Inactive 10.1016/J.STR.2018.10.027 2019-01-02
6P9X CRFR1 CRF1 Corticotropin-releasing factor B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Corticoliberin pubchem
Agonist 2.9 Active 10.1016/J.MOLCEL.2020.01.012 2020-02-05
6CM4 DRD2 D2 Dopamine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 6 chems 7.8-7.8 20°C Risperidone pubchem chembl_ligand
Inverse agonist 2.9 Inactive 10.1038/NATURE25758 2018-03-14
3V2Y S1PR1 S1P1 Lysophospholipid (S1P) A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.8-7.8 20°C (R)-3-Amino-4-(3-hex... pubchem
Antagonist 2.8 Inactive 10.1126/SCIENCE.1215904 2012-02-15
5UNF AGTR2 AT2 Angiotensin A (Rhodopsin) Human BaculovirusSf21Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 7 chems 8.0-8.0 20°C N-Benzyl-N-[2-ethyl-... pubchem
Antagonist 2.8 Active 10.1038/NATURE22035 2017-04-05
6ME4 MTR1A MT1 Melatonin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2-Iodomelatonin pubchem chembl_ligand
Agonist 3.2 Inactive 10.1038/S41586-019-1141-3 2019-04-24
7L1U OX2R OX2 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A orexin-A
Agonist 3.2 Active 10.1038/S41467-021-21087-6 2021-02-10
6MEO CCR5 CCR5 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Envelope glycoprotei...
Antagonist 3.9 Inactive 10.1038/S41586-018-0804-9 2018-12-12
7CA3 GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A BHFF pubchem
PAM 4.5 Active 10.1016/J.JMB.2020.09.023 2020-11-11
6KUY ADA2A α2A Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (2~{S})-4-fluoranyl-... pubchem
Agonist (partial) 3.2 Inactive 2019-12-04
6DRY 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Methylergonovine pubchem chembl_ligand
Agonist 2.9 Intermediate 10.1038/S41594-018-0116-7 2018-08-29
4QKX ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)7.7 MAG 5 chems 7.8-8.4 20°C Q27453560 pubchem
Agonist 3.3 Active 10.1073/PNAS.1410415111 2014-07-23
4LDL ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)7.7 MAG 5 chems 6.5-6.5 20°C Hydroxybenzylisoprot... pubchem
Agonist 3.1 Active 10.1038/NATURE12572 2013-09-25
6KJV GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PF-06372222 pubchem
NAM 2.8 Inactive 10.1107/S2052252519013496 2019-11-13
6WQA AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ZM241385 pubchem
Antagonist 2.0 Inactive 10.1107/S2052252520012701 2020-11-18
6PS1 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Timolol pubchem
Antagonist 3.2 Inactive 10.1107/S2052252519013137 2019-11-13
6IBL ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Formoterol pubchem chembl_ligand
Agonist 2.7 Active 10.1101/436212 2019-01-09
6LFL CXCR2 CXCR2 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4-[[3,4-Dioxo-2-[[(1... pubchem
Allosteric antagonist 3.2 Inactive 10.1038/S41586-020-2492-5 2020-09-02
6OY9 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Retinal pubchem
Agonist 3.9 Active 10.1016/J.MOLCEL.2019.06.007 2019-07-24
5A8E ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 7.0-7.0 20°C 7-methylcyanopindolo... pubchem
Inverse agonist 2.4 Inactive 10.1124/MOL.115.101030 2015-09-30
6AKX CCR5 CCR5 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N-[(1S)-3-{(3-exo)-3...
Antagonist 2.8 Inactive 10.1021/ACS.JMEDCHEM.8B01077 2018-10-24
2YDV AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusHi5Insect 4 chemicals 4 steps vapour diffusionsitting drop 5 chems 6.4-6.4 4°C NECA pubchem
Agonist 2.6 Active 10.1038/NATURE10136 2011-05-18
4QIM SMO SMO Frizzled F (Frizzled) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 5 chems 7.2-7.2 20°C AntaXV pubchem
Antagonist 2.6 Inactive 10.1038/NCOMMS5355 2014-07-23
6Z10 SUCR1 succinate Succinate A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2-[2-[[3-[4-chlorany... pubchem
Antagonist 2.3 Intermediate 10.1021/ACS.JMEDCHEM.0C01020 2020-09-16
7DTU CASR CaS Calcium-sensing C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Tryptophan pubchem chembl_ligand
PAM 4.4 Inactive 10.1038/S41422-021-00474-0 2021-03-10
6WI9 SCTR secretin Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A secretin
Agonist 4.3 Active 10.1038/S41467-020-17791-4 2020-08-12
5ZBQ NPY1R Y1 Neuropeptide Y A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 7.4-8.0 19–22 °C UR-MK299 pubchem
Antagonist 2.7 Inactive 10.1038/S41586-018-0046-X 2018-04-25
6D35 Q98SW5 SMO Frizzled F (Frizzled) African clawed frog BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.0-6.5 20°C Cholesterol pubchem
Agonist 3.9 Active 10.1016/J.CELL.2018.04.029 2018-05-23
6UP7 NTR1 NTS1 Neurotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ARG-ARG-PRO-TYR-ILE-...
Agonist 4.2 Active 10.1038/S41586-020-1953-1 2020-02-26
3ODU CXCR4 CXCR4 Chemokine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.5-5.5 20°C IT1t pubchem
Antagonist 2.5 Inactive 10.1126/SCIENCE.1194396 2010-10-27
4DJH OPRK κ Opioid A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.0-6.0 20°C JDTic pubchem
Antagonist 2.9 Inactive 10.1038/NATURE10939 2012-03-21
5D5A ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.5-7.0 20°C Carazolol pubchem
Inverse agonist 2.5 Inactive 10.1107/S2059798315021683 2016-01-13
6QZH CCR7 CCR7 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SCHEMBL13407377 pubchem
Allosteric antagonist 2.1 Inactive 10.1016/J.CELL.2019.07.028 2019-09-04
7DDZ NPY2R Y2 Neuropeptide Y A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A JNJ-31020028 pubchem chembl_ligand
Antagonist 2.8 Inactive 2021-01-27
6PS8 MTR1A MT1 Melatonin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2-phenylmelatonin pubchem
Agonist 3.3 Inactive 10.1107/S2052252519013137 2019-11-13
7CKZ DRD1 D1 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A dopamine pubchem
Mevidalen pubchem
AgonistPAM 3.1 Active 10.1016/J.CELL.2021.01.028 2021-03-03
4RWA OPRD δ Opioid A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 6.0-6.0 20°C DIPP-NH2
Antagonist 3.3 Inactive 10.1038/NSMB.2965 2015-01-14
6GPS CCR2 CCR2 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A MK-0812 pubchem
Antagonist 3.3 Inactive 10.1016/J.STR.2018.10.027 2019-01-02
7DFP DRD2 D2 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Spiperone pubchem
Antagonist 3.1 Inactive 10.1038/S41467-020-20221-0 2020-12-30
4OR2 GRM1 mGlu1 Metabotropic glutamate C (Glutamate) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.0-7.0 20°C FITM pubchem
NAM 2.8 Inactive 10.1126/SCIENCE.1249489 2014-03-19
6PB1 CRFR2 CRF2 Corticotropin-releasing factor B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Urocortin pubchem chembl_ligand
Agonist 2.8 Active 10.1016/J.MOLCEL.2020.01.013 2020-02-12
6XBM SMO SMO Frizzled F (Frizzled) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 24,25-Epoxy-choleste... pubchem
24,25-Epoxy-choleste... pubchem
AgonistPAM 3.2 Active 10.1038/S41589-020-0646-2 2020-09-30
2R4S ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps vapour diffusionhanging drop 5 chems 6.5-7.5 22°C N/A N/A 3.4 Inactive 10.1038/NATURE06325 2007-11-06
3V2W S1PR1 S1P1 Lysophospholipid (S1P) A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.8-7.8 20°C (R)-3-Amino-4-(3-hex... pubchem
Antagonist 3.4 Inactive 10.1126/SCIENCE.1215904 2012-02-15
5LWE CCR9 CCR9 Chemokine A (Rhodopsin) Human BaculovirusSf21Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.9-8.0 20°C Vercirnon pubchem
Allosteric antagonist 2.8 Inactive 10.1038/NATURE20606 2016-12-07
7CKW DRD1 D1 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Fenoldopam pubchem
Agonist 3.2 Active 10.1016/J.CELL.2021.01.028 2021-03-03
4S0V OX2R OX2 Orexin A (Rhodopsin) Human BaculovirusSf9Insect 9 chemicals 9 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.9-6.0 20°C Suvorexant pubchem
Antagonist 2.5 Inactive 10.1038/NATURE14035 2015-01-14
3CAP OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionHanging drop 4 chems 5.6-5.6 4°C Apo (no ligand)
Apo (no ligand) 2.9 Active 10.1038/NATURE07063 2008-06-24
5TE5 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionHanging drop 4 chems 5.2-6.6 4°C 10,20-Methanoretinal pubchem
Agonist 4.0 Inactive 10.1073/PNAS.1617446114 2017-03-15
6KQI CNR1 CB1 Cannabinoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CP55940 pubchem
ORG27569 pubchem chembl_ligand
AgonistNAM 3.3 Inactive 10.1038/S41589-019-0387-2 2019-10-23
6IBB SUCR1 succinate Succinate A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.1 Intermediate 10.1038/S41586-019-1663-8 2019-08-14
6NBI PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Long-acting parathyr...
Agonist 4.0 Active 10.1126/SCIENCE.AAV7942 2019-04-17
4BVN ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 7.0-7.0 22°C (S)-Cyanopindolol pubchem
Antagonist 2.1 Inactive 10.1371/JOURNAL.PONE.0092727 2014-04-02
6LN2 GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PF-06372222 pubchem
NAM 3.2 Inactive 10.1038/S41467-020-14934-5 2020-03-18
6WZG SCTR secretin Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A secretin
Agonist 2.3 Active 10.1038/S41467-020-17791-4 2020-08-12
6OIK ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Iperoxo pubchem
2CU pubchem
AgonistPAM 3.6 Active 10.1126/SCIENCE.AAW5188 2019-05-08
5TUD 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human BaculovirusSf21Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monopalmitolein (9.7 MAG) 6 chems 7.7-7.7 20°C Ergotamine pubchem
Agonist 3.0 Active 10.1073/PNAS.1700891114 2017-07-26
5YWY PE2R4 EP4 Prostanoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ONO-AE3-208 pubchem
Antagonist 3.2 Inactive 10.1038/S41589-018-0131-3 2018-12-05
6LI0 GPR52 GPR52 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A c17 pubchem
Agonist 2.2 Intermediate 10.1038/S41586-020-2019-0 2020-02-26
6RNK SUCR1 succinate Succinate A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A NF-56-EJ40 pubchem
Antagonist 1.9 Intermediate 10.1038/S41586-019-1663-8 2019-08-14
4Z34 LPAR1 LPA1 Lysophospholipid (LPA) A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.5-5.5 20°C ONO-9780307 pubchem
Antagonist 3.0 Inactive 10.1016/J.CELL.2015.06.002 2015-06-03
2YCZ ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 2 chemicals 2 steps vapour diffusionNA 3 chems 6.9-7.3 NA Iodocyanopindolol pubchem
Antagonist 3.7 Inactive 10.1073/PNAS.1100185108 2011-06-01
5W0P OPSD Rhodopsin Opsins A (Rhodopsin) Human Transient_transfectionHEK293S(TetR- GnTI-Mammalian 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monopalmitolein (9.7 MAG) 5 chems 5.0-5.0 20°C Apo (no ligand)
Apo (no ligand) 3.0 Active 10.1016/J.CELL.2017.07.002 2017-08-09
6OYA OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Retinal pubchem
Agonist 3.3 Active 10.1016/J.MOLCEL.2019.06.007 2019-07-24
7AD3 STE2 STE2 STE2 D1 (Ste2-like fungal pheromone) strain ATCC 204508 / S288c N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Alpha-factor mating ... pubchem
Agonist 3.5 Active 10.1038/S41586-020-2994-1 2020-12-09
4BEY OPSD Rhodopsin Opsins A (Rhodopsin) Bovine Stable_cellsHEK293S(TetR)GnTI-Mammalian 1 chemicals 1 steps vapour diffusionsitting drop 4 chems 4.5-4.5 20°C Apo (no ligand)
Apo (no ligand) 2.9 Active 10.1038/EMBOR.2013.44 2013-05-08
6FK7 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine BaculovirusHEK293S(TetR)-GnTI-Mammalian 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 4.5-4.5 20°C (2~{R},3~{R})-2-(4-c... pubchem
Agonist 2.6 Active 10.1073/PNAS.1718084115 2018-04-04
5KW2 FFAR1 FFA1 Free fatty acid A (Rhodopsin) Human BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 8.5-8.5 20°C (3~{S})-3-cyclopropy... pubchem
Agonist 2.8 Intermediate 10.1038/S41467-017-01240-W 2018-05-02
6J20 NK1R NK1 Tachykinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Aprepitant pubchem pubchem chembl_ligand
Antagonist 2.7 Inactive 10.1038/S41467-019-08568-5 2019-03-06
1F88 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 2 chemicals 2 steps vapour diffusionHanging drop 7 chems 6.0-6.0 4°C Retinal pubchem
Inverse agonist 2.8 Inactive 10.1126/SCIENCE.289.5480.739 2000-08-04
6S0L AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ZM241385 pubchem
Antagonist 2.7 Inactive 10.1107/S2052252520011379 2020-07-15
6J21 NK1R NK1 Tachykinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Aprepitant pubchem pubchem chembl_ligand
Antagonist 3.2 Inactive 10.1038/S41467-019-08568-5 2019-03-06
6HLO NK1R NK1 Tachykinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Aprepitant pubchem pubchem chembl_ligand
Antagonist 2.4 Inactive 10.1038/S41467-018-07939-8 2019-01-16
6BQH 5HT2C 5-HT2C 5-Hydroxytryptamine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 5 chems 6.0-6.0 20°C Ritanserin pubchem
Inverse agonist 2.7 Inactive 10.1016/J.CELL.2018.01.001 2018-02-14
6LI3 GPR52 GPR52 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.3 Active 10.1038/S41586-020-2019-0 2020-02-26
7C7Q GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A BHFF pubchem
Baclofen pubchem
PAMAgonist 3.0 Active 10.1038/S41422-020-0350-5 2020-07-01
5X7D ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 3 chemicals 3 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 7 chems 7.5-7.5 20°C 4-carbamoyl-N-[(2R)-... pubchem
Carazolol pubchem
Allosteric antagonistAntagonist 2.7 Inactive 10.1038/NATURE23652 2017-08-16
5UVI AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.0-5.0 20°C ZM241385 pubchem
Antagonist 3.2 Inactive 10.1107/S205225251700570X 2017-05-24
6RZ5 CLTR1 CysLT1 Leukotriene A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Zafirlukast pubchem chembl_ligand
Antagonist 2.5 Intermediate 10.1126/SCIADV.AAX2518 2019-10-30
5WQC OX2R OX2 Orexin A (Rhodopsin) Human BaculovirusSf9Insect 9 chemicals 9 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 4 chems 5.8-6.2 20°C EMPA pubchem chembl_ligand
Antagonist 2.0 Inactive 10.1016/J.STR.2017.11.005 2017-11-29
1U19 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 6.5-7.5 283 K Retinal pubchem
Inverse agonist 2.2 Inactive 10.1016/J.JMB.2004.07.044 2004-10-12
6MET CCR5 CCR5 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Envelope glycoprotei...
Antagonist 4.5 Inactive 10.1038/S41586-018-0804-9 2018-12-12
2I37 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 2 chemicals 2 steps vapour diffusionsitting drops 5 chems 7.0-8.0 5°C Apo (no ligand)
Apo (no ligand) 4.2 Inactive 10.1073/PNAS.0608022103 2006-10-17
2YCY ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 2 chemicals 2 steps vapour diffusionNA 3 chems 6.9-7.3 NA (S)-Cyanopindolol pubchem
Antagonist 3.2 Inactive 10.1073/PNAS.1100185108 2011-06-08
5XR8 CNR1 CB1 Cannabinoid A (Rhodopsin) Human Transient_transfectionHEK293TMammalian 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 6.2-6.2 20°C (6Ar,9R,10aR)-9-(hyd... pubchem
Agonist 3.0 Active 10.1038/NATURE23272 2017-07-12
6LFM CXCR2 CXCR2 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Interleukin-8 pubchem
Agonist 3.5 Active 10.1038/S41586-020-2492-5 2020-09-02
6WJC ACM1 M1 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Muscarinic toxin 7
Hyoscyamine pubchem
NAMAntagonist 2.6 Inactive 10.1126/SCIENCE.AAX2517 2020-07-08
5DHH OPRX NOP Opioid A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.4-6.4 20°C SB-612111 pubchem
Antagonist 3.0 Inactive 10.1016/J.STR.2015.07.024 2015-10-21
5N2S AA1R A1 Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 7.5-7.5 20°C PSB36 pubchem
Agonist 3.3 Inactive 10.1016/J.STR.2017.06.012 2017-07-26
2Z73 OPSD Rhodopsin Opsins A (Rhodopsin) Japanese flying squid NANativeSquid 1 chemicals 1 steps vapour diffusionsitting drops 5 chems 6.4-6.4 4°C Retinal pubchem
Inverse agonist 2.5 Inactive 10.1038/NATURE06925 2008-05-13
6PS3 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (S)-Carvedilol pubchem
Antagonist 2.5 Inactive 10.1107/S2052252519013137 2019-11-13
6DS0 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A LY266097 pubchem
Antagonist 3.2 Intermediate 10.1038/S41594-018-0116-7 2018-08-29
4U15 ACM3 M3 Acetylcholine (muscarinic) A (Rhodopsin) Rat BaculovirusSf9Insect 9 chemicals 9 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.5-7.5 298 K Tiotropium pubchem
Antagonist 2.8 Inactive 10.1016/J.STR.2014.08.022 2014-11-26
6LI1 GPR52 GPR52 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.9 Intermediate 10.1038/S41586-020-2019-0 2020-02-26
2I35 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 2 chemicals 2 steps vapour diffusionsitting drops 5 chems 7.0-8.0 5°C Retinal pubchem
Inverse agonist 3.8 Inactive 10.1073/PNAS.0608022103 2006-10-17
6D27 PD2R2 DP2 Prostanoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CAY10471 pubchem chembl_ligand
Antagonist 2.7 Inactive 10.1016/J.MOLCEL.2018.08.009 2018-10-03
5ZBH NPY1R Y1 Neuropeptide Y A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A BMS-193885 pubchem
Antagonist 3.0 Inactive 10.1038/S41586-018-0046-X 2018-04-25
6VCB GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A GLP-1
LSN3160440 pubchem
AgonistPAM 3.3 Active 10.1038/S41589-020-0589-7 2020-07-22
2HPY OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 5.9-6.1 283 K Retinal pubchem
Agonist 2.8 Inactive 10.1073/PNAS.0601765103 2006-08-22
3OE0 CXCR4 CXCR4 Chemokine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.0-6.0 20°C CVX15
Antagonist 2.9 Inactive 10.1126/SCIENCE.1194396 2010-10-27
6IIU TA2R TP Prostanoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Ramatroban pubchem chembl_ligand
Antagonist 2.5 Intermediate 10.1038/S41589-018-0170-9 2018-12-19
6UVA CALRL calcitonin-like Calcitonin B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Adrenomedullin-2
Agonist 2.3 Active 10.1021/ACSPTSCI.9B00080 2020-04-01
7C2E GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2-[[4-[6-[(4-cyano-2... pubchem
Agonist 4.2 Active 10.1038/S41422-020-0384-8 2020-08-26
6H7L ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Dobutamine pubchem
Agonist 2.7 Active 10.1126/SCIENCE.AAU5595 2018-10-17
5ZKQ PTAFR PAF Platelet-activating factor A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ABT-491 pubchem chembl_ligand
Inverse agonist 2.9 Intermediate 10.1038/S41594-018-0068-Y 2018-06-20
6FK6 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine BaculovirusHEK293S(TetR)-GnTI-Mammalian 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 4.5-4.5 20°C (2~{S})-2-(4-chlorop... pubchem
Agonist 2.4 Active 10.1073/PNAS.1718084115 2018-04-04
6OL9 ACM5 M5 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Tiotropium pubchem
Inverse agonist 2.5 Inactive 10.1073/PNAS.1914446116 2019-12-11
7JVR DRD2 D2 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Bromocriptine pubchem
Agonist 2.8 Active 10.1016/J.CELL.2021.01.027 2021-02-24
6JZH AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ZM241385 pubchem
Antagonist 2.3 Inactive 10.1107/S1600576719012846 2019-10-30
6PT2 OPRD δ Opioid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A KGCHM07
Agonist 2.8 Active 10.1126/SCIADV.AAX9115 2019-12-11
4LDE ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)7.7 MAG 5 chems 6.5-6.5 20°C BI-167107 pubchem
Agonist 2.8 Active 10.1038/NATURE12572 2013-09-25
4Z36 LPAR1 LPA1 Lysophospholipid (LPA) A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.5-5.5 20°C ONO-3080573 pubchem
Antagonist 2.9 Inactive 10.1016/J.CELL.2015.06.002 2015-06-03
6DO1 AGTR1 AT1 Angiotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (Sar1,Ile8)-Angioten... pubchem chembl_ligand
Agonist 2.9 Active 10.1016/J.CELL.2018.12.006 2019-01-30
5K2C AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.0-5.0 20°C ZM241385 pubchem
Antagonist 1.9 Inactive 10.1126/SCIADV.1600292 2016-09-21
5NX2 GLP1R GLP-1 Glucagon B1 (Secretin) Human BaculovirusSf9Insect 2 chemicals 2 steps vapour diffusionSitting drop 4 chems 8.0-9.0 10°C Truncated protein ag...
Agonist 3.7 Intermediate 10.1038/NATURE22800 2017-06-14
5MZP AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20 Caffeine pubchem
Antagonist 2.1 Inactive 10.1016/J.STR.2017.06.012 2017-07-26
6S0Q AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ZM241385 pubchem
Antagonist 2.7 Inactive 2020-07-15
6XBK SMO SMO Frizzled F (Frizzled) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Cholesterol pubchem
Agonist 3.2 Active 10.1038/S41589-020-0646-2 2020-09-30
4AMI ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 2 chemicals 2 steps vapour diffusionsitting drops 3 chems 9.0-9.0 4°C Bucindolol pubchem
Agonist 3.2 Inactive 10.1016/J.STR.2012.03.014 2012-05-23
3D4S ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.0-7.0 20°C Timolol pubchem
Inverse agonist 2.8 Inactive 10.1016/J.STR.2008.05.001 2008-06-17
6LW5 FPR2 FPR2/ALX Formylpeptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A WKYMVm
Agonist 2.8 Active 10.1038/S41467-020-15009-1 2020-03-25
6B73 OPRK κ Opioid A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 7 chems 6.5-7.0 20°C MP1104 pubchem
Agonist 3.1 Active 10.1016/J.CELL.2017.12.011 2018-01-17
7DFL HRH1 H1 Histamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A histamine pubchem
Agonist 3.3 Active 2021-03-31
7CUM GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Unknown ligand
CGP54626 pubchem
NAMAntagonist 3.5 Active 10.1016/J.JMB.2020.09.023 2020-11-11
3UON ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.5-7.5 19.85°C QNB pubchem
Antagonist 3.0 Inactive 10.1038/NATURE10753 2012-02-01
5IUB AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.5-5.5 20°C Q27456344 pubchem
Antagonist 2.1 Inactive 10.1021/ACS.JMEDCHEM.6B00653 2016-06-29
5OM1 AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20°C 4-(3-amino-5-phenyl-... pubchem
Antagonist 2.1 Inactive 10.1038/S41598-017-18570-W 2018-01-17
6KUW ADA2C α2C Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (8Ar,12aS,13aR)-12-e... pubchem
Antagonist 2.8 Inactive 2019-12-04
5WF6 AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.0-5.0 20°C UK-432097 pubchem
Agonist 2.9 Active 10.1016/J.STR.2017.12.013 2018-02-21
5V56 SMO SMO Frizzled F (Frizzled) Human Transient_transfectionHEK293FMammalian 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.0-5.0 20°C N-methyl-N-[1-[4-(2-... pubchem
Antagonist 2.9 Inactive 10.1038/NCOMMS15383 2017-05-24
6KP6 ACM4 M4 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.0 Inactive 10.1107/S2052252520000597 2020-03-11
7LCJ GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PF-06882961 pubchem
Agonist 2.8 Active 2021-01-20
6OSA NTR1 NTS1 Neurotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A JMV449 pubchem
Agonist 3.0 Active 10.1038/S41586-019-1337-6 2019-07-10
6W25 MC4R MC4 Melanocortin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SHU9119
Calcium ion pubchem
AntagonistCofactor 2.8 Intermediate 10.1126/SCIENCE.AAZ8995 2020-04-29
2YCX ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 2 chemicals 2 steps vapour diffusionNA 3 chems 6.9-7.3 NA (S)-Cyanopindolol pubchem
Antagonist 3.3 Inactive 10.1073/PNAS.1100185108 2011-06-01
6ME5 MTR1A MT1 Melatonin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Agomelatine pubchem chembl_ligand
Agonist 3.2 Inactive 10.1038/S41586-019-1141-3 2019-04-24
6LFO CXCR2 CXCR2 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Interleukin-8 pubchem
Agonist 3.4 Active 10.1038/S41586-020-2492-5 2020-09-02
5UZ7 CALCR CT Calcitonin B1 (Secretin) Human BaculovirusHi5Insect 2 chemicals 2 steps Cryo-EMVolta phase plate (FEI) 6 chems 7.4-7.4 cryoTemp(liquid Nitrogen) N/A N/A 4.1 Active 10.1038/NATURE22327 2017-05-03
3DQB OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionhanging drops 5 chems 5.9-6.1 10°C Apo (no ligand)
Apo (no ligand) 3.2 Active 10.1038/NATURE07330 2008-09-23
4MBS CCR5 CCR5 Chemokine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.0-7.0 20°C Maraviroc pubchem
Antagonist 2.7 Inactive 10.1126/SCIENCE.1241475 2013-09-11
6MXT ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Salmeterol pubchem
Agonist 3.0 Active 10.1038/S41589-018-0145-X 2018-11-14
5YQZ GLR glucagon Glucagon B1 (Secretin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)MAG 7.8 5 chems 8.0-8.0 20°C NNC1702
Agonist (partial) 3.0 Inactive 10.1038/NATURE25153 2018-01-17
2RH1 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.8-6.8 21-23°C Carazolol pubchem
Inverse agonist 2.4 Inactive 10.1126/SCIENCE.1150577 2007-10-30
6LRY EDNRB ETB Endothelin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Sarafotoxin S6b pubchem
Agonist 3.0 Inactive 10.1016/J.BBRC.2019.12.091 2020-02-12
6WHA 5HT2A 5-HT2A 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 25-CN-NBOH pubchem
Agonist 3.4 Active 10.1016/J.CELL.2020.08.024 2020-09-23
7L0P NTR1 NTS1 Neurotensin A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A neurotensin pubchem chembl_ligand
Agonist 4.1 Active 2021-01-06
2X72 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine Stable_cellsHEK293S-GnTI-Mammalian 1 chemicals 1 steps vapour diffusionsitting drop 3 chems 4.5-4.5 4°C Retinal pubchem
Agonist 3.0 Active 10.1038/NATURE09795 2011-03-16
6RZ9 CLTR2 CysLT2 Leukotriene A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ONO-2770372 pubchem
Antagonist 2.7 Intermediate 10.1038/S41467-019-13348-2 2019-12-11
3RFM AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps vapour diffusionsitting drop 6 chems 8.0-8.8 4°C Caffeine pubchem
Antagonist 3.6 Inactive 10.1016/J.STR.2011.06.014 2011-09-07
5NDD PAR2 PAR2 Proteinase-activated A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.5-6.2 20°C AZ8838 pubchem
Antagonist 2.8 Intermediate 10.1038/NATURE22309 2017-05-03
7LCK GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PF-06882961 pubchem
Agonist 3.2 Active 2021-01-20
3NY9 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.5-8.0 20°C Q27461782 pubchem
Inverse agonist 2.8 Inactive 10.1021/JA105108Q 2010-08-11
6FFI GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human BaculovirusSf21Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 5.5-6.8 20°C 2-[2-(3-methoxypheny... pubchem
NAM 2.2 Inactive 10.1021/ACS.JMEDCHEM.7B01722 2018-03-07
6WGT 5HT2A 5-HT2A 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Lysergide pubchem
Agonist 3.4 Inactive 10.1016/J.CELL.2020.08.024 2020-09-23
6FKB OPSD Rhodopsin Opsins A (Rhodopsin) Bovine BaculovirusHEK293S(TetR)-GnTI-Mammalian 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 4.5-4.5 20°C 2-(4-chlorophenyl)-1... pubchem
Agonist 3.0 Active 10.1073/PNAS.1718084115 2018-04-04
5IUA AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20 2-(Furan-2-yl)-5-N-[... pubchem
Antagonist 2.2 Inactive 10.1021/ACS.JMEDCHEM.6B00653 2016-06-29
3ZEV NTR1 NTS1 Neurotensin A (Rhodopsin) Rat NAE. coli BL21(DE3)Bacteria 3 chemicals 3 steps vapour diffusionsitting drops 7 chems 9.4-9.4 4°C neurotensin pubchem chembl_ligand
Agonist 3.0 Inactive 10.1073/PNAS.1317903111 2014-01-29
6PT3 OPRD δ Opioid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A DPI-287 pubchem
Agonist 3.3 Active 10.1126/SCIADV.AAX9115 2019-12-11
4MQS ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.2-7.9 20°C Iperoxo pubchem
Agonist 3.5 Active 10.1038/NATURE12735 2013-11-27
6XBJ SMO SMO Frizzled F (Frizzled) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Cholesterol pubchem
Agonist 3.9 Active 10.1038/S41589-020-0646-2 2020-09-30
3OE9 CXCR4 CXCR4 Chemokine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 6.0-6.0 20°C IT1t pubchem
Antagonist 3.1 Inactive 10.1126/SCIENCE.1194396 2010-10-27
6TQ9 OX1R OX1 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SB-408124 pubchem chembl_ligand
Antagonist 2.7 Inactive 10.1021/ACS.JMEDCHEM.9B01787 2020-01-01
4EA3 OPRX NOP Opioid A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.4-6.4 20°C C-24 pubchem
Antagonist 3.0 Inactive 10.1038/NATURE11085 2012-04-25
6TPG OX2R OX2 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A EMPA pubchem chembl_ligand
Antagonist 2.7 Inactive 10.1021/ACS.JMEDCHEM.9B01787 2020-01-01
6OMM FPR2 FPR2/ALX Formylpeptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A WKYMVX
Agonist 3.2 Active 10.1038/S41467-020-14728-9 2020-02-26
4UHR AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusHi5Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 4.8-4.8 22°C CGS-21680 pubchem
Agonist 2.6 Active 10.1124/MOL.114.097360 2015-04-08
6IIV TA2R TP Prostanoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Daltroban pubchem chembl_ligand
Antagonist 3.0 Intermediate 10.1038/S41589-018-0170-9 2018-12-19
4NC3 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 8.0-8.0 20°C Ergotamine pubchem
Agonist 2.8 Intermediate 10.1126/SCIENCE.1244142 2013-12-18
4J4Q OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionHanging drop 3 chems 5.2-6.0 4°C B-Octylglucoside pubchem
unknown 2.7 Active 10.1002/ANIE.201302374 2013-10-30
6X1A GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PF-06882961 pubchem
Agonist 2.5 Active 10.1101/2020.08.16.252585 2020-09-09
5OLV AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20°C CHEMBL1671936 pubchem chembl_ligand
Antagonist 2.0 Inactive 10.1038/S41598-017-18570-W 2018-01-17
3UZA AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps vapour diffusionsitting drop 6 chems 8.0-8.0 4°C 6-(2,6-Dimethylpyrid... pubchem
Antagonist 3.3 Inactive 10.1021/JM201376W 2012-03-21
7L0Q NTR1 NTS1 Neurotensin A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A neurotensin pubchem chembl_ligand
Agonist 4.3 Active 2021-01-06
6H7N ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Xamoterol pubchem
Agonist 2.5 Active 10.1101/436212 2018-10-17
5VEW GLP1R GLP-1 Glucagon B1 (Secretin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 6.2-6.6 20°C PF-06372222 pubchem
NAM 2.7 Inactive 10.1038/NATURE22378 2017-05-24
6LPK AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ZM241385 pubchem
Antagonist 1.8 Inactive 10.1038/S41598-020-76277-X 2020-11-25
5DSG ACM4 M4 Acetylcholine (muscarinic) A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.5-8.0 20°C Tiotropium pubchem
Antagonist 2.6