Experiment Browser

Show/hide columns:



Loading...
RECEPTOR EXPRESSION SOLUBILIZATION PURIFICATION STRUCTURE DETERMINATION
PDB pH Temp Resolution Reference Date
7PX4 AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Preladenant conjugat... pubchem
Antagonist 2.3 Inactive 10.1002/ANIE.202115545 2022-03-02
6OS9 NTR1 NTS1 Neurotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A JMV449 pubchem gtoplig chembl_ligand
Agonist 3.0 Active 10.1038/S41586-019-1337-6 2019-07-10
5D6L ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.0-7.0 20°C Carazolol pubchem
Inverse agonist 3.2 Inactive 10.1038/NPROT.2017.057 2016-08-17
7WY0 AGRF1 ADGRF1 ADGRF B2 (Adhesion) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 2.8 Active 10.1038/S41467-022-33173-4 2022-09-28
6WPW GLR glucagon Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Glucagon derivative ...
Agonist 3.1 Active 10.1126/SCIENCE.ABA3373 2020-08-12
6LPL AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 2.0 Inactive 10.1038/S41598-020-76277-X 2020-11-25
7X2C DRD1 D1 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A fenoldopam pubchem gtoplig chembl_ligand drugbank drug_central pubchem gtoplig chembl_ligand pubchem pubchem gtoplig chembl_ligand pubchem
Agonist 3.2 Active 10.1038/S41467-022-30929-W 2022-06-29
3NY8 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.5-8.0 20°C ICI 118551 pubchem gtoplig chembl_ligand chembl_ligand pubchem
Inverse agonist 2.8 Inactive 10.1021/JA105108Q 2010-08-11
3D4S ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.0-7.0 20°C timolol pubchem gtoplig chembl_ligand drugbank drug_central
Inverse agonist 2.8 Inactive 10.1016/J.STR.2008.05.001 2008-06-17
7W40 GRPR BB2 Bombesin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Bombesin
Agonist 3.0 Active 10.1073/PNAS.2216230120 2023-02-22
5NJ6 PAR2 PAR2 Proteinase-activated A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 7 chems 5.5-6.2 20°C N/A N/A 4.0 Intermediate 10.1038/NATURE22309 2017-05-03
7X2D DRD1 D1 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A TAVAPADON chembl_ligand pubchem
Agonist 3.3 Active 10.1038/S41467-022-30929-W 2022-06-15
8HJ5 MRGX1 MRGPRX1 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A compound 16 [PMID: 3... pubchem gtoplig chembl_ligand
Agonist 3.0 Active 2023-05-31
7F1R CCR5 CCR5 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CCL5 gtoplig
Agonist 3.0 Active 2021-07-14
8DWC MRGX1 MRGPRX1 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Proenkephalin-A
Agonist 2.9 Active 10.1038/S41589-022-01173-6 2022-11-02
8I2G FSHR FSH Glycoprotein hormone A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Glycoprotein alpha
Follitropin subunit ...
FSHR agonist 1 pubchem
AgonistAgonistAllosteric agonist 2.8 Active 10.1038/S41467-023-36170-3 2023-03-29
7PIV MC4R MC4 Melanocortin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A afamelanotide pubchem gtoplig chembl_ligand drugbank pubchem pubchem pubchem pubchem
Agonist 2.9 Active 10.1038/S41422-021-00569-8 2021-11-17
3EML AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.5-6.5 20°C ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 2.6 Inactive 10.1126/SCIENCE.1164772 2008-10-14
6XBK SMO SMO Frizzled F (Frizzled) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Cholesterol pubchem
Agonist 3.2 Active 10.1038/S41589-020-0646-2 2020-09-30
6PWC NTR1 NTS1 Neurotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL48981 chembl_ligand pubchem
Agonist 4.9 Active 10.1038/S41422-019-0256-2 2019-12-04
7WVX FPR2 FPR2/ALX Formylpeptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A humanin pubchem gtoplig chembl_ligand pubchem
Agonist 2.8 Active 10.1038/S41467-022-29361-X 2022-04-13
7X9Y CCR3 CCR3 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.1 Active 10.1038/S41421-022-00403-4 2022-08-24
6BQG 5HT2C 5-HT2C 5-Hydroxytryptamine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 5 chems 6.0-6.0 20°C ergotamine pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.0 Active 10.1016/j.cell.2018.01.001 2018-02-14
5MZJ AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20 theophylline pubchem gtoplig chembl_ligand drugbank drug_central
Antagonist 2.0 Inactive 10.1016/j.str.2017.06.012 2017-07-26
6TKO ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A arformoterol pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.3 Active 10.1038/S41586-020-2419-1 2020-06-17
7BVQ ADRB1 β1 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Carazolol pubchem
Inverse agonist 2.5 Inactive 10.1038/S41422-020-00424-2 2020-12-02
7SK6 ACKR3 ACKR3 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Stromal cell-derived...
Agonist 4.0 Active 10.1126/SCIADV.ABN8063 2022-07-27
7BZ2 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A arformoterol pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.8 Active 10.1038/S41421-020-0176-9 2020-08-05
6NI3 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL1615159 chembl_ligand pubchem
Agonist 3.8 Active 10.1038/S41594-019-0330-Y 2019-11-20
7TYH CALCR CT Calcitonin B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Calcitonin human pubchem
Agonist 3.3 Active 2022-03-23
8F7Q OPRM μ Opioid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A β-endorphin pubchem gtoplig chembl_ligand pubchem
Agonist 3.2 Active 10.1016/J.CELL.2022.12.026 2022-12-14
7XV3 GP174 GPR174 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (2~{S})-2-$l^{4}-aza... pubchem
Agonist 2.8 Active 10.1038/S41467-023-36575-0 2023-02-15
7TRP ACM4 M4 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A iperoxo pubchem gtoplig chembl_ligand
LY2033298 pubchem gtoplig chembl_ligand
AgonistPAM 2.4 Active 2023-05-17
6D26 PD2R2 DP2 Prostanoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A fevipiprant pubchem gtoplig chembl_ligand drugbank
Antagonist 2.8 Inactive 10.1016/J.MOLCEL.2018.08.009 2018-10-03
3VW7 PAR1 PAR1 Proteinase-activated A (Rhodopsin) Human BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.0-6.5 20°C vorapaxar pubchem gtoplig chembl_ligand drug_central drugbank
Antagonist 2.2 Intermediate 10.1038/NATURE11701 2012-12-12
5XF1 GLR glucagon Glucagon B1 (Secretin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.0-7.0 20°C NNC0640 pubchem gtoplig
NAM 3.2 Inactive 10.1038/NATURE22363 2017-05-24
7WVW FPR2 FPR2/ALX Formylpeptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A FME-TYR-PHE-ILE-ASN-...
Agonist 3.1 Active 10.1038/S41467-022-29361-X 2022-04-13
7VVO PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Parathyroid hormone
Agonist 4.1 Active 10.1016/J.MOLCEL.2022.07.003 2022-08-03
8FLT PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A M-PTH(1-14)
Agonist 3.0 Active 10.1016/J.STR.2023.04.002 2023-04-26
8F7S OPRD δ Opioid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A DELTORPHIN II chembl_ligand pubchem
Agonist 3.0 Active 10.1016/J.CELL.2022.12.026 2022-12-14
7WQ3 GALR1 GAL1 Galanin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A galanin gtoplig chembl_ligand gtoplig pubchem pubchem pubchem pubchem pubchem
Agonist 2.7 Active 10.1038/S41467-022-29072-3 2022-04-20
5JQH ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)7.7 MAG 5 chems 7.5-7.5 23°C Carazolol pubchem
Inverse agonist 3.2 Inactive 10.1038/NATURE18636 2016-07-13
8GNG AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A istradefylline pubchem gtoplig chembl_ligand drug_central drugbank
Antagonist 3.2 Inactive 10.1124/MOLPHARM.122.000633 2023-03-22
7WC8 5HT2A 5-HT2A 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A LUMATEPERONE chembl_ligand chembl_ligand pubchem
Agonist 2.5 Inactive 10.1126/SCIENCE.ABL8615 2022-01-26
7F8Y CCKAR CCK1 Cholecystokinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A DEVAZEPIDE chembl_ligand pubchem
Antagonist 2.5 Inactive 10.1038/S41589-021-00866-8 2021-10-13
7VBH GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Peptide 20
Agonist 3.0 Active 10.1038/S41467-022-28683-0 2022-04-06
6ME8 MTR1B MT2 Melatonin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL15060 chembl_ligand pubchem
Agonist 3.1 Inactive 10.1038/S41586-019-1144-0 2019-04-24
6Z66 NTR1 NTS1 Neurotensin A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.2 Intermediate 10.1126/sciadv.abe5504 2021-02-10
6DS0 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A LY266097 pubchem
Antagonist 3.2 Intermediate 10.1038/s41594-018-0116-7 2018-08-29
7XK8 NMUR2 NMU2 Neuromedin U A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Neuromedin U-25 (hum... pubchem
Agonist 3.3 Active 10.1038/S41467-022-34814-4 2023-02-22
5TVN 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human BaculovirusSf21Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.5-8.0 20°C Lysergide pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 2.9 Intermediate 10.1016/J.CELL.2016.12.033 2017-02-01
6ME9 MTR1B MT2 Melatonin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ramelteon pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.3 Inactive 10.1038/S41586-019-1144-0 2019-04-24
8FMZ NTR1 NTS1 Neurotensin A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A neurotensin pubchem gtoplig chembl_ligand gtoplig gtoplig
Agonist 2.6 Active 10.1021/ACS.BIOCHEM.3C00029 2023-03-29
6G79 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps Cryo-EMVolta phase plate, Falcon III detector (FEI Titan Krios, 300kV) 5 chems 7.5-7.5 4°C donitriptan pubchem gtoplig chembl_ligand
Agonist 3.8 Active 10.1038/S41586-018-0241-9 2018-06-20
5NLX AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 5 chems 5.0-5.0 20°C ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 2.1 Inactive 10.1038/S41467-017-00630-4 2017-09-27
6UOA GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 6.3 Intermediate 10.1038/S41586-020-2408-4 2020-06-10
7PIU MC4R MC4 Melanocortin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A setmelanotide pubchem gtoplig drug_central chembl_ligand drugbank
Agonist 2.6 Active 10.1038/S41422-021-00569-8 2021-11-17
5ZKP PTAFR PAF Platelet-activating factor A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A foropafant pubchem gtoplig chembl_ligand
Antagonist 2.8 Other 10.1038/S41594-018-0068-Y 2018-06-20
7YU6 LPAR1 LPA1 Lysophospholipid (LPA) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A [(2~{R})-2-[5-(2-hex... pubchem
Agonist 3.5 Active 10.1038/S41467-022-33121-2 2022-10-05
7EPT AGRD1 ADGRD1 ADGRD B2 (Adhesion) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.0 Active 10.1038/S41586-022-04619-Y 2022-05-11
5DGY OPSD Rhodopsin Opsins A (Rhodopsin) Human Transient_transfectionHEK293SMammalian 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monopalmitolein (9.7 MAG) 5 chems 5.0-5.0 20°C Apo (no ligand)
Apo (no ligand) 7.7 Active 10.1038/SDATA.2016.21 2016-03-23
4L6R GLR glucagon Glucagon B1 (Secretin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.0-7.0 20°C N/A N/A 3.3 Inactive 10.1038/nature12393 2013-07-24
7F1S CCR5 CCR5 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 2.8 Active 10.1038/S41467-021-24438-5 2021-07-14
2YCY ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 2 chemicals 2 steps vapour diffusionNA 3 chems 6.9-7.3 NA (S)-Cyanopindolol pubchem
Antagonist 3.2 Inactive 10.1073/PNAS.1100185108 2011-06-08
7EZK CCKAR CCK1 Cholecystokinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CCK-8 pubchem gtoplig chembl_ligand drug_central drugbank
Agonist 3.1 Active 10.1038/S41589-021-00841-3 2021-08-25
7EW7 S1PR1 S1P1 Lysophospholipid (S1P) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SEW2871 pubchem gtoplig chembl_ligand
Agonist 3.3 Active 10.1038/S41422-021-00566-X 2021-09-29
6KUY ADA2A α2A Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (2~{S})-4-fluoranyl-... pubchem
Agonist (partial) 3.2 Inactive 2019-12-04
7WVV FPR2 FPR2/ALX Formylpeptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A synthetic peptide
Agonist 2.9 Active 10.1038/S41467-022-29361-X 2022-04-13
6K42 ADA2B α2B Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A dexmedetomidine pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 4.1 Active 10.1038/S41589-020-0492-2 2020-04-15
5VBL APJ apelin Apelin A (Rhodopsin) Human BaculovirusSf21Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 7 chems 6.1-6.1 20-22°C AMG3054 gtoplig
Agonist 2.6 Inactive 10.1016/J.STR.2017.04.008 2017-05-31
3V2W S1PR1 S1P1 Lysophospholipid (S1P) A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.8-7.8 20°C W146 pubchem gtoplig chembl_ligand
Antagonist 3.4 Inactive 10.1126/SCIENCE.1215904 2012-02-15
7CX3 PE2R2 EP2 Prostanoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A taprenepag pubchem gtoplig chembl_ligand drugbank
Agonist 2.8 Active 10.1126/SCIADV.ABF1268 2021-05-05
7RGP GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A tirzepatide pubchem gtoplig
Agonist 2.9 Active 10.1073/PNAS.2116506119 2022-04-13
7DH5 ADRB3 β3 Adrenoceptors A (Rhodopsin) Dog N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A mirabegron pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.2 Active 10.1016/J.MOLCEL.2021.06.024 2021-08-04
7DHI ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A levosalbutamol pubchem gtoplig chembl_ligand drug_central drugbank
Agonist 3.3 Active 10.1093/NSR/NWAA284 2020-12-16
5A8E ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 7.0-7.0 20°C 7-methylcyanopindolo... pubchem
Inverse agonist 2.4 Inactive 10.1124/MOL.115.101030 2015-09-30
7DD6 CASR CaS Calcium-sensing C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Calcium pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem
AgonistPAM 3.2 Active 10.1126/SCIADV.ABG1483 2021-06-16
8G59 FFAR4 FFA4 Free fatty acid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A TUG-891 pubchem gtoplig chembl_ligand
Agonist 2.6 Active 10.1126/SCIENCE.ADD6220 2023-03-08
5X93 EDNRB ETB Endothelin A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.0-7.0 20°C K-8794 pubchem gtoplig
Antagonist 2.2 Inactive 10.1038/NSMB.3450 2017-08-16
6LRY EDNRB ETB Endothelin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A sarafotoxin S6b pubchem gtoplig chembl_ligand chembl_ligand pubchem
Agonist 3.0 Inactive 10.1016/J.BBRC.2019.12.091 2020-02-12
7X1U TRFR TRH1 Thyrotropin-releasing hormone A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A TRH pubchem
Agonist 3.2 Active 10.1038/S41422-022-00646-6 2022-08-31
7W6P ADA2A α2A Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N-pyridin-4-ylisoqui... pubchem
Agonist 3.5 Active 10.1126/SCIENCE.ABN7065 2022-09-28
7VDH MRGX2 MRGPRX2 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A compound 48/80 pubchem gtoplig
Agonist 2.9 Active 10.1038/S41586-021-04077-Y 2021-12-01
8HDP AA2BR A2B Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A adenosine pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.2 Active 10.1038/S41421-022-00503-1 2023-01-18
7TYY CALCR CT Calcitonin B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Calcitonin salmon pubchem
Agonist 3.0 Active 10.1126/SCIENCE.ABM9609 2022-03-23
7XTC 5HT7R 5-HT7 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5-CT pubchem gtoplig chembl_ligand
Agonist 3.2 Active 10.1016/J.MOLCEL.2022.05.031 2022-07-27
7DTU CASR CaS Calcium-sensing C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem
PAM 4.4 Intermediate 2021-03-10
5K2C AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.0-5.0 20°C ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 1.9 Inactive 10.1126/SCIADV.1600292 2016-09-21
7YAC SSR2 SST2 Somatostatin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Paltusotine pubchem
Agonist 3.2 Active 10.1038/S41467-023-36673-Z 2023-04-19
7MT9 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Retinal (all-trans) pubchem
Agonist 7.0 Active 10.1038/S41586-021-03721-X 2021-07-07
2J4Y OPSD Rhodopsin Opsins A (Rhodopsin) Bovine Transient_transfectionCOS1Mammalian 1 chemicals 1 steps vapour diffusionsitting drops 3 chems 7.5-7.5 4°C Retinal (11-cis) pubchem
Inverse agonist 3.4 Inactive 10.1016/J.JMB.2007.03.007 2007-09-25
8E9X ACM4 M4 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL73538 chembl_ligand pubchem
Agonist 2.7 Active 10.1038/S41586-022-05489-0 2022-11-30
7WY5 AGRL3 ADGRL3 ADGRL B2 (Adhesion) Mouse N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 2.8 Active 10.1016/J.MOLCEL.2022.10.009 2022-10-26
7EXD 5HT1F 5-HT1F 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A lasmiditan pubchem gtoplig chembl_ligand drug_central drugbank
Agonist 3.4 Active 10.1038/S41422-021-00527-4 2021-08-04
7SK4 ACKR3 ACKR3 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Stromal cell-derived...
Agonist 3.3 Active 10.1126/SCIADV.ABN8063 2022-07-27
5X33 Q9WTK1 BLT1 Leukotriene A (Rhodopsin) Guinea pig Pichia PastorisP. pastoris SMD1163Yeast 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 7 chems 8.5-9.0 4°C BIIL 260 pubchem gtoplig
Antagonist 3.7 Inactive 10.1038/NCHEMBIO.2547 2018-01-03
7RKF US28 US28 Unclassified A (Rhodopsin) strain AD169 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Fractalkine pubchem
Agonist 4.0 Active 10.1126/SCIADV.ABL5442 2022-01-26
5UNG AGTR2 AT2 Angiotensin A (Rhodopsin) Human BaculovirusSf21Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 7 chems 8.0-8.0 20°C compound 1 [PMID: 28... pubchem gtoplig chembl_ligand
Antagonist 2.8 Active 10.1038/NATURE22035 2017-04-05
1F88 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 2 chemicals 2 steps vapour diffusionHanging drop 7 chems 6.0-6.0 4°C Retinal (11-cis) pubchem
Inverse agonist 2.8 Inactive 10.1126/SCIENCE.289.5480.739 2000-08-04
7XBD GALR2 GAL2 Galanin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Galanin, Human pubchem
Agonist 3.1 Active 10.1371/JOURNAL.PBIO.3001714 2022-07-13
7T2G OPRM μ Opioid A (Rhodopsin) Mouse N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL58362 chembl_ligand pubchem
Agonist 2.5 Active 10.1038/S41589-022-01208-Y 2022-12-07
7XMR SSR2 SST2 Somatostatin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SOMATOSTATIN chembl_ligand pubchem
Agonist 3.1 Active 10.1038/S41422-022-00679-X 2022-08-03
7F8V GASR CCK2 Cholecystokinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A desulfated gastrin-1... pubchem gtoplig chembl_ligand pubchem
Agonist 3.3 Active 10.1038/S41589-021-00866-8 2021-10-13
7DTV CASR CaS Calcium-sensing C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Calcium pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem
AgonistPAM 3.5 Active 10.1038/S41422-021-00474-0 2021-03-10
7DGE GRM1 mGlu1 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A quisqualate pubchem gtoplig chembl_ligand drugbank gtoplig pubchem
Agonist 3.7 Intermediate 10.1007/S13238-020-00808-5 2021-09-22
4BEZ OPSD Rhodopsin Opsins A (Rhodopsin) Bovine Stable_cellsHEK293S-GnTI-Mammalian 1 chemicals 1 steps vapour diffusionsitting drop 4 chems 4.5-4.5 20°C Apo (no ligand)
Apo (no ligand) 3.3 Active 10.1038/EMBOR.2013.44 2013-04-24
7XW5 TSHR TSH Glycoprotein hormone A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Glycoprotein hormone...
Thyrotropin subunit ...
N-[4-[[5-[(2S)-3-ben... pubchem
AgonistAgonistPAM 3.0 Active 10.1038/S41586-022-05173-3 2022-08-24
7XA3 CCR2 CCR2 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A C-C motif chemokine ...
Agonist 2.9 Active 10.1038/S41421-022-00403-4 2022-08-24
7WYB AGRL3 ADGRL3 ADGRL B2 (Adhesion) Mouse N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.0 Active 10.1016/J.MOLCEL.2022.10.009 2022-10-26
7XOW GASR CCK2 Cholecystokinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A desulfated gastrin-1... pubchem gtoplig chembl_ligand pubchem
Agonist 3.1 Active 10.1038/S41421-022-00420-3 2022-07-20
6AQF AA2AR A2A Adenosine A (Rhodopsin) Human Pichia PastorisP. pastoris SMD1163Yeast 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.0-5.0 20°C ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 2.5 Inactive 10.1016/J.CELL.2017.12.004 2018-01-10
7Y64 C5AR1 C5a1 Complement peptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A C5a anaphylatoxin
Agonist 2.9 Active 10.1038/S41422-023-00779-2 2023-03-01
6WW2 FZD5 FZD5 Frizzled F (Frizzled) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.7 Inactive 10.7554/ELIFE.58464 2020-08-19
4PHU FFAR1 FFA1 Free fatty acid A (Rhodopsin) Human BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.6-7.6 20°C fasiglifam pubchem gtoplig chembl_ligand drugbank
Allosteric agonist 2.3 Intermediate 10.1038/NATURE13494 2014-07-16
7E9H GRM4 mGlu4 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A L-serine-O-phosphate pubchem gtoplig chembl_ligand drugbank drug_central pubchem
Agonist 4.0 Intermediate 10.1038/S41586-021-03495-2 2021-06-23
7YP7 AGRG2 ADGRG2 ADGRG B2 (Adhesion) Mouse N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.1 Active 2022-08-24
5K2D AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.0-5.0 20°C ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 1.9 Inactive 10.1126/SCIADV.1600292 2016-09-21
7T6T FPR1 FPR1 Formylpeptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A synthetic peptide
Agonist 3.2 Active 10.1038/S41467-022-28586-0 2022-03-30
6N52 GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.0 Inactive 10.1038/S41586-019-0881-4 2019-01-23
5OLO AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20°C tozadenant pubchem gtoplig chembl_ligand drugbank
Antagonist 3.1 Inactive 10.1038/S41598-017-18570-W 2018-01-17
5OLV AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20°C CHEMBL1671936 chembl_ligand pubchem
Antagonist 2.0 Inactive 10.1038/S41598-017-18570-W 2018-01-17
6NBH PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Long-acting parathyr...
Agonist 3.5 Active 10.1126/SCIENCE.AAV7942 2019-04-17
8DCS ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4-{[(2S)-3-(tert-but... pubchem
Agonist 2.5 Active 10.1038/S41467-022-31823-1 2022-07-27
8EFB OPRM μ Opioid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A OLICERIDINE chembl_ligand pubchem
Agonist 3.2 Active 10.1016/J.CELL.2022.09.041 2022-11-09
6UUS CALRL calcitonin-like Calcitonin B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Adrenomedullin pubchem
Agonist 2.4 Active 10.1021/ACSPTSCI.9B00080 2020-04-01
8IW1 TAAR9 TAAR9 A orphans A (Rhodopsin) Mouse N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2-Phenylethanaminium pubchem
Agonist 3.4 Active 10.1038/S41586-023-06106-4 2023-05-31
8FLR PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PTHrP[1-36]
Agonist 2.9 Active 10.1016/J.STR.2023.04.002 2023-04-26
7PP1 P2Y12 P2Y12 P2Y A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A selatogrel pubchem
Antagonist 2.8 Intermediate 10.1016/j.bcp.2022.115291 2022-11-02
6ZG9 ACM1 M1 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7-fluoro-5-methyl-3-... pubchem
Agonist 2.5 Inactive 10.1016/J.CELL.2021.11.001 2021-10-06
7T9M TSHR TSH Glycoprotein hormone A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CS-17 heavy chain
CS-17 light chain
Inverse agonistInverse agonist 3.1 Inactive 10.1038/S41586-022-05159-1 2022-08-10
6LI2 GPR52 GPR52 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 2.8 Inactive 10.1038/S41586-020-2019-0 2020-02-26
7X2F DRD1 D1 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A mevidalen pubchem gtoplig chembl_ligand
dopamine pubchem gtoplig chembl_ligand drugbank drug_central
PAMAgonist 3.0 Active 10.1038/S41467-022-30929-W 2022-06-15
8DZR OPRK κ Opioid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL277863 chembl_ligand pubchem
Agonist 2.6 Active 10.1038/S41586-023-06030-7 2023-05-03
7VVJ PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PTHrP[1-36]
Agonist 3.2 Active 10.1016/J.MOLCEL.2022.07.003 2022-08-03
6K41 ADA2B α2B Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A dexmedetomidine pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 2.9 Active 10.1038/S41589-020-0492-2 2020-04-15
7XT8 5HT4R 5-HT4 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5-hydroxytryptamine pubchem gtoplig chembl_ligand drugbank
Agonist 3.1 Active 10.1016/J.MOLCEL.2022.05.031 2022-07-27
7NA8 GHSR ghrelin Ghrelin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ibutamoren pubchem gtoplig chembl_ligand
Agonist 2.7 Active 10.1038/S41467-021-26735-5 2021-12-15
6TQ9 OX1R OX1 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SB-408124 pubchem gtoplig chembl_ligand
Antagonist 2.7 Inactive 10.1021/acs.jmedchem.9b01787 2020-01-01
7L0P NTR1 NTS1 Neurotensin A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A neurotensin pubchem gtoplig chembl_ligand gtoplig gtoplig
Agonist 4.1 Active 10.1038/S41594-020-00554-6 2021-01-06
7D68 GLP2R GLP-2 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A glucagon pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem pubchem pubchem pubchem
Agonist 3.0 Active 10.1038/S41422-020-00442-0 2020-12-16
7WU5 AGRF1 ADGRF1 ADGRF B2 (Adhesion) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.0 Active 10.1038/S41586-022-04580-W 2022-04-27
7WI6 GRM3 mGlu3 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A LY341495 pubchem gtoplig chembl_ligand gtoplig
Antagonist 3.7 Inactive 10.1038/S41422-022-00623-Z 2022-03-16
7CKY DRD1 D1 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL3697578 chembl_ligand pubchem
Agonist 3.2 Active 10.1016/J.CELL.2021.01.028 2021-03-03
7WVU FPR1 FPR1 Formylpeptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A FME-LEU-PHE
Agonist 3.3 Active 10.1038/S41467-022-29361-X 2022-04-13
7EVY S1PR1 S1P1 Lysophospholipid (S1P) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A siponimod pubchem gtoplig chembl_ligand drug_central drugbank
Agonist 3.0 Active 10.1038/S41422-021-00566-X 2021-09-29
6E3Y CALRL calcitonin-like Calcitonin B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Calcitonin gene-rela... pubchem
Agonist 3.3 Active 10.1038/S41586-018-0535-Y 2018-09-19
6RZ6 CLTR2 CysLT2 Leukotriene A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ONO-2570366 pubchem gtoplig
Antagonist 2.4 Intermediate 10.1038/S41467-019-13348-2 2019-12-11
7EZC AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A UK-432,097 pubchem gtoplig chembl_ligand drugbank
Agonist 3.8 Active 10.1107/S2052252522001907 2022-04-13
7UM6 5HT5A 5-HT5A 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A lisuride pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 2.8 Active 10.1038/S41594-022-00796-6 2022-07-20
8ID8 FFAR4 FFA4 Free fatty acid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A TUG-891 pubchem gtoplig chembl_ligand
Agonist 3.0 Active 10.1126/SCIENCE.ADD6220 2023-03-15
6LMK GLR glucagon Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A glucagon pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem pubchem pubchem pubchem
Agonist 3.7 Active 10.1126/SCIENCE.AAZ5346 2020-04-01
7TYW CALCR CT Calcitonin B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Calcitonin salmon pubchem
Agonist 3.0 Active 10.1126/SCIENCE.ABM9609 2022-03-23
6H7N ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (S)-Xamoterol pubchem
Agonist 2.5 Active 10.1101/436212 2018-10-17
7LD4 AA1R A1 Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A adenosine pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.3 Active 10.1038/S41586-021-03897-2 2021-09-08
7L0S NTR1 NTS1 Neurotensin A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A neurotensin pubchem gtoplig chembl_ligand gtoplig gtoplig
Agonist 4.5 Active 10.1038/S41594-020-00554-6 2021-01-06
7U2L OPRM μ Opioid A (Rhodopsin) Mouse N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N-(5-carbamimidamido...
Agonist 3.2 Active 10.1038/S41586-022-05588-Y 2022-05-04
7T6U FPR2 FPR2/ALX Formylpeptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A synthetic peptide
Agonist 2.9 Active 10.1038/S41467-022-28586-0 2022-03-30
6WIV GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A [(2R)-3-[(Z)-icos-11... pubchem
(2R)-3-{[(S)-(2-amin... pubchem
NAMNAM 3.3 Inactive 10.1038/S41586-020-2452-0 2020-07-01
7ZI0 SMO SMO Frizzled F (Frizzled) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3-chloro-N-[trans-4-... pubchem
Antagonist 3.0 Inactive 10.1126/SCIADV.ABM5563 2022-06-15
7TYO CALCR CT Calcitonin B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Calcitonin human pubchem
Agonist 2.7 Active 10.1126/SCIENCE.ABM9609 2022-03-23
4PXF OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionsitting drop 3 chems 6.0-6.0 4°C B-Octylglucoside pubchem
unknown 2.8 Active 10.1038/NCOMMS5801 2014-09-17
6PS3 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL3799125 chembl_ligand pubchem
Antagonist 2.5 Inactive 10.1107/S2052252519013137 2019-11-13
7VBI GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A tirzepatide pubchem gtoplig
Agonist 3.0 Active 10.1038/S41467-022-28683-0 2022-03-02
7WUI AGRG2 ADGRG2 ADGRG B2 (Adhesion) Mouse N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A IP15
Agonist 3.1 Active 10.1038/S41586-022-04590-8 2022-04-27
7V6A ACM4 M4 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A methyl 4-[4-(3-methy... pubchem
Allosteric agonist 3.6 Active 10.1038/S41467-022-30595-Y 2022-05-11
6WH4 5HT2A 5-HT2A 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL428892 chembl_ligand pubchem
Inverse agonist 3.4 Inactive 10.1016/J.CELL.2020.08.024 2020-09-23
7KI0 GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A semaglutide pubchem gtoplig chembl_ligand drugbank pubchem
Agonist 2.5 Active 10.1016/J.CELREP.2021.109374 2021-08-04
4DJH OPRK κ Opioid A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.0-6.0 20°C JDTic pubchem gtoplig chembl_ligand
Antagonist 2.9 Inactive 10.1038/NATURE10939 2012-03-21
5U09 CNR1 CB1 Cannabinoid A (Rhodopsin) Human BaculovirusSf21Insect 9 chemicals 9 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.5-5.5 20°C taranabant pubchem gtoplig chembl_ligand drugbank
Inverse agonist 2.6 Inactive 10.1038/NATURE20613 2016-12-07
7CA5 GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 7.6 Inactive 10.1016/J.JMB.2020.09.023 2020-11-11
7RA3 GIPR GIP Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A gastric inhibitory p... pubchem
Agonist 3.2 Active 10.1073/PNAS.2116506119 2022-04-13
7S8N MRGX2 MRGPRX2 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (R)-ZINC-3573 pubchem gtoplig chembl_ligand
Agonist 2.9 Active 10.1038/S41586-021-04126-6 2021-11-17
2Y03 ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 1 chemicals 1 steps vapour diffusionsitting drops 6 chems 8.5-8.5 4°C LEVISOPRENALINE chembl_ligand chembl_ligand pubchem
Agonist 2.9 Inactive 10.1038/NATURE09746 2011-01-12
8IRT DRD3 D3 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A rotigotine pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 2.7 Active 10.1038/S41422-023-00808-0 2023-06-07
8IA8 C3AR C3a Complement peptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ALA-SER-LYS-LEU-GLY-...
Agonist 2.9 Active 2023-05-24
7XBW CX3C1 CX3CR1 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 2.8 Active 10.1126/SCIADV.ABN8048 2022-07-13
6WQA AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 2.0 Inactive 10.1107/S2052252520012701 2020-11-18
6GPS CCR2 CCR2 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A MK-0812 pubchem
Antagonist 3.3 Inactive 10.1016/J.STR.2018.10.027 2019-01-02
7KH0 V2R V2 Vasopressin and oxytocin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A vasopressin pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 2.8 Active 10.1038/S41422-021-00483-Z 2021-05-26
6IBB SUCR1 succinate Succinate A (Rhodopsin) Rat N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.1 Active 10.1038/S41586-019-1663-8 2019-08-14
7X9C NPY4R Y4 Neuropeptide Y A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Pancreatic polypepti... pubchem
Agonist 3.0 Active 10.1126/SCIADV.ABM1232 2022-05-18
7WXU AGRF1 ADGRF1 ADGRF B2 (Adhesion) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 2.9 Active 10.1038/S41467-022-33173-4 2022-09-28
6FKC OPSD Rhodopsin Opsins A (Rhodopsin) Bovine BaculovirusHEK293S(TetR)-GnTI-Mammalian 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 4.5-4.5 20°C 3-[1'-[(2~{S})-2-(4-... pubchem
Agonist 2.5 Active 10.1073/PNAS.1718084115 2018-04-04
7S8O MRGX2 MRGPRX2 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (R)-ZINC-3573 pubchem gtoplig chembl_ligand
Agonist 2.6 Active 10.1038/S41586-021-04126-6 2021-11-17
4AMI ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 2 chemicals 2 steps vapour diffusionsitting drops 3 chems 9.0-9.0 4°C Bucindolol pubchem
Agonist 3.2 Inactive 10.1016/J.STR.2012.03.014 2012-05-23
5ZKQ PTAFR PAF Platelet-activating factor A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ABT-491 pubchem gtoplig chembl_ligand
Inverse agonist 2.9 Intermediate 10.1038/S41594-018-0068-Y 2018-06-20
6OMM FPR2 FPR2/ALX Formylpeptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL552527 chembl_ligand pubchem
Agonist 3.2 Active 10.1038/S41467-020-14728-9 2020-02-26
7F61 HRH3 H3 Histamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N-ethyl-3-fluoro-3-[... pubchem
Antagonist 2.6 Inactive 10.1038/S41467-022-33880-Y 2022-10-26
6JZH AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 2.3 Inactive 10.1107/S1600576719012846 2019-10-30
4MQS ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.2-7.9 20°C iperoxo pubchem gtoplig chembl_ligand
Agonist 3.5 Active 10.1038/NATURE12735 2013-11-27
7W0M APJ apelin Apelin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (1R,2S)-N-[4-(2,6-di... pubchem
Agonist 3.7 Active 10.1038/S41594-022-00797-5 2022-07-27
5IU4 AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.5-5.5 20 ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 1.7 Inactive 10.1021/acs.jmedchem.6b00653 2016-06-29
7XKF AGRG2 ADGRG2 ADGRG B2 (Adhesion) Mouse N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PRASTERONE chembl_ligand pubchem
Agonist 2.4 Active 10.1038/S41589-022-01084-6 2022-08-10
7AD3 STE2 STE2 STE2 D1 (Ste2-like fungal pheromone) strain ATCC 204508 / S288c N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Alpha-factor mating ... pubchem
Agonist 3.5 Active 10.1038/S41586-020-2994-1 2020-12-09
6H7J ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A LEVISOPRENALINE chembl_ligand chembl_ligand pubchem
Agonist 2.8 Active 10.1126/SCIENCE.AAU5595 2018-10-17
6WZG SCTR secretin Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SECRETIN chembl_ligand pubchem
Agonist 2.3 Active 10.1038/S41467-020-17791-4 2020-08-12
8GUQ CNR2 CB2 Cannabinoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A olorinab pubchem gtoplig chembl_ligand drugbank
Agonist 3.1 Active 10.1038/S41467-023-37112-9 2023-05-10
4QKX ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)7.7 MAG 5 chems 7.8-8.4 20°C Q27453560 pubchem
Agonist 3.3 Active 10.1073/PNAS.1410415111 2014-07-23
6FK8 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine BaculovirusHEK293S(TetR)-GnTI-Mammalian 1 chemicals 1 steps vapour diffusionHanging drops 5 chems 4.5-4.5 20°C (2~{R},3~{S})-3-azan... pubchem
Agonist 2.9 Active 10.1073/PNAS.1718084115 2018-04-04
4XNV P2RY1 P2Y1 P2Y A (Rhodopsin) Human BaculovirusSf9Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.5-6.5 20°C BMS compound 16 [PMI... pubchem gtoplig chembl_ligand
NAM 2.2 Intermediate 10.1038/NATURE14287 2015-04-01
7EVZ S1PR1 S1P1 Lysophospholipid (S1P) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A cenerimod pubchem gtoplig chembl_ligand drugbank
Agonist 3.1 Active 10.1038/S41422-021-00566-X 2021-09-29
7WJ5 SSR2 SST2 Somatostatin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SOMATOSTATIN chembl_ligand pubchem
Agonist 3.7 Active 10.7554/ELIFE.76823 2022-07-13
8E3Y VIPR1 VPAC1 VIP and PACAP B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A [Ac-His<sup>1</sup>]... gtoplig chembl_ligand pubchem
Agonist 2.3 Active 10.1038/S41467-022-34629-3 2022-11-23
3OE0 CXCR4 CXCR4 Chemokine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.0-6.0 20°C CVX15
Antagonist 2.9 Inactive 10.1126/SCIENCE.1194396 2010-10-27
5UVI AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.0-5.0 20°C ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 3.2 Inactive 10.1107/S205225251700570X 2017-05-24
8ITF TAAR9 TAAR9 A orphans A (Rhodopsin) Mouse N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N,N-Dimethylcyclohex... pubchem
Agonist 3.5 Active 10.1038/S41586-023-06106-4 2023-05-31
7DGD GRM1 mGlu1 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 4.0 Inactive 10.1007/S13238-020-00808-5 2021-09-22
4QIM SMO SMO Frizzled F (Frizzled) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 5 chems 7.2-7.2 20°C ANTA XV pubchem gtoplig chembl_ligand
Antagonist 2.6 Inactive 10.1038/NCOMMS5355 2014-07-23
4Z9G CRFR1 CRF1 Corticotropin-releasing factor B1 (Secretin) Human BaculovirusHi5Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 5.5-5.5 23°C CP 376,395 pubchem gtoplig chembl_ligand
Antagonist 3.2 Inactive 10.2174/1874467210666170110114727 2016-06-29
7S15 GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL5191519 chembl_ligand pubchem
Agonist 3.8 Active 10.1021/acs.jmedchem.1c01856 2022-06-08
7LLL GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A exendin-4 pubchem gtoplig pubchem
Agonist 3.7 Active 10.1038/S41467-021-27760-0 2022-01-12
7JNI AGTR2 AT2 Angiotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A olodanrigan pubchem gtoplig chembl_ligand drugbank
Antagonist 3.0 Active 10.1073/PNAS.2116289119 2022-02-09
7C7Q GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (-)-baclofen pubchem gtoplig chembl_ligand drugbank drugbank gtoplig pubchem
BHFF pubchem
AgonistPAM 3.0 Active 10.1038/S41422-020-0350-5 2020-07-01
7RMI NK1R NK1 Tachykinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A substance P pubchem gtoplig chembl_ligand gtoplig gtoplig
Agonist 3.2 Active 10.1038/S41589-021-00890-8 2021-11-03
4XT3 US28 US28 Unclassified A (Rhodopsin) strain AD169 BaculovirusHEK293S(TetR)-GnTI-Mammalian 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monovaccenin(11.7 MAG) 6 chems 7.4-7.4 20°C CX3CL1 gtoplig
Agonist (partial) 3.8 Active 10.1126/SCIENCE.AAA5026 2015-03-04
6DDE OPRM μ Opioid A (Rhodopsin) Mouse BaculovirusSf9Insect 4 chemicals 4 steps Cryo-EMGatan K2 Summit direct electron camera , 300kV 5 chems 7.5-7.5 4°C DAMGO pubchem gtoplig chembl_ligand chembl_ligand
Agonist 3.5 Active 10.1038/S41586-018-0219-7 2018-06-13
7F8U CCKAR CCK1 Cholecystokinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A lintitript pubchem gtoplig chembl_ligand drugbank
Antagonist 2.8 Inactive 10.1038/S41589-021-00866-8 2021-10-13
7XJJ GALR1 GAL1 Galanin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A galanin gtoplig chembl_ligand gtoplig pubchem pubchem pubchem pubchem pubchem
Agonist 3.3 Active 2023-05-03
7YU4 LPAR1 LPA1 Lysophospholipid (LPA) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A [(2~{R})-2-[5-(2-hex... pubchem
Agonist 3.3 Active 10.1038/S41467-022-33121-2 2022-10-05
7YU5 LPAR1 LPA1 Lysophospholipid (LPA) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A [(2~{R})-2-[5-(2-hex... pubchem
Agonist 3.3 Active 10.1038/S41467-022-33121-2 2022-10-05
5EN0 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine Stable_cellsHEK293S(TetR)GnTI-Mammalian 1 chemicals 1 steps vapour diffusionSitting drop 4 chems 5.0-5.0 4°C Retinal (all-trans) pubchem
Agonist 2.8 Active 10.15252/EMBR.201642671 2016-08-10
8HBD EDNRB ETB Endothelin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A sovateltide pubchem gtoplig chembl_ligand gtoplig pubchem pubchem
Agonist 3.0 Active 2023-03-22
4N6H OPRD δ Opioid A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 7 chems 6.1-6.2 20-23°C naltrindole pubchem gtoplig chembl_ligand gtoplig
Antagonist 1.8 Inactive 10.1038/NATURE12944 2013-12-25
6TPJ OX2R OX2 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A suvorexant pubchem gtoplig chembl_ligand drug_central drugbank
Antagonist 2.7 Inactive 10.1021/acs.jmedchem.9b01787 2020-01-01
6ME3 MTR1A MT1 Melatonin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL15060 chembl_ligand pubchem
Agonist 2.9 Inactive 10.1038/S41586-019-1141-3 2019-04-24
2YDO AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusHi5Insect 4 chemicals 4 steps vapour diffusionsitting drop 5 chems 7.6-7.6 4°C adenosine pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.0 Active 10.1038/NATURE10136 2011-05-18
7T6B S1PR2 S1P2 Lysophospholipid (S1P) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A sphingosine 1-phosph... pubchem gtoplig chembl_ligand pubchem
Agonist 3.2 Active 10.1126/SCIADV.ABN0067 2022-04-06
6X1A GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A danuglipron pubchem gtoplig chembl_ligand
Agonist 2.5 Active 10.1016/J.MOLCEL.2020.09.020 2020-09-09
4BWB NTR1 NTS1 Neurotensin A (Rhodopsin) Rat NAE. coli BL21(DE3)Bacteria 3 chemicals 3 steps vapour diffusionsitting drops 7 chems 5.5-5.5 4°C neurotensin pubchem gtoplig chembl_ligand gtoplig gtoplig
Agonist 3.6 Inactive 10.1073/PNAS.1317903111 2014-01-29
7FD9 GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A LY341495 pubchem gtoplig chembl_ligand gtoplig
Antagonist 4.0 Inactive 10.1016/J.CELREP.2021.109648 2021-09-08
5L7I SMO SMO Frizzled F (Frizzled) Human Transient_transfectionHEK293S(TetR)-GnTI-Mammalian 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 8 chems 6.0-6.0 20°C vismodegib pubchem gtoplig chembl_ligand drugbank drug_central
Antagonist 3.3 Inactive 10.1038/NATURE18934 2016-07-20
7VL8 CCR1 CCR1 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 2.9 Active 10.1038/S41589-021-00918-Z 2022-03-23
7WCN GP119 GPR119 GPR18, GPR55 and GPR119 A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A AR231453 pubchem gtoplig chembl_ligand
Agonist 2.9 Active 10.1038/S41467-022-34696-6 2022-12-21
7X2V AGRF1 ADGRF1 ADGRF B2 (Adhesion) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.1 Active 10.1038/S41467-022-33173-4 2022-09-28
7LCI GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A danuglipron pubchem gtoplig chembl_ligand
Agonist 2.9 Active 10.1016/J.STR.2021.04.008 2021-01-20
7EO2 S1PR1 S1P1 Lysophospholipid (S1P) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (S)-FTY720-phosphate pubchem gtoplig chembl_ligand
Agonist 2.9 Active 10.1038/S41589-021-00930-3 2022-01-05
7CFM GPBAR GPBA Bile acid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL2331646 chembl_ligand pubchem
Agonist 3.0 Active 10.1038/S41586-020-2569-1 2020-09-09
6B3J GLP1R GLP-1 Glucagon B1 (Secretin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 2 chemicals 2 steps Cryo-EMVolta phase plate (FEI) 5 chems 7.4-7.4 4°C Exendin-P5
Agonist 3.3 Active 10.1038/NATURE25773 2018-02-21
8HK5 C5AR1 C5a1 Complement peptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A C5a gtoplig
Agonist 3.0 Active 10.1038/S41589-023-01339-W 2023-05-10
3DQB OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionhanging drops 5 chems 5.9-6.1 10°C Apo (no ligand)
Apo (no ligand) 3.2 Active 10.1038/NATURE07330 2008-09-23
7Y14 MRGRD MRGPRD A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A β-alanine pubchem gtoplig chembl_ligand drugbank pubchem
Agonist 3.2 Active 10.1038/S42003-022-03668-3 2022-07-20
3PDS ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 3 chemicals 3 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 6.7-6.7 20°C FAUC50 pubchem
Agonist 3.5 Inactive 10.1038/NATURE09665 2011-01-12
6M1I PACR PAC1 VIP and PACAP B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A [Ac-His<sup>1</sup>]... gtoplig chembl_ligand pubchem
Agonist 3.5 Active 10.1038/S41422-020-0280-2 2020-03-11
4RWD OPRD δ Opioid A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.0-6.0 20°C DIPP-NH2
Antagonist 2.7 Inactive 10.1038/NSMB.2965 2015-01-14
7LJC DRD1 D1 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A mevidalen pubchem gtoplig chembl_ligand
CHEMBL1160787 chembl_ligand pubchem
PAMAgonist 3.0 Active 10.1038/S41422-021-00482-0 2021-03-03
4N4W SMO SMO Frizzled F (Frizzled) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 7 chems 6.9-6.9 20°C SANT-1 pubchem gtoplig chembl_ligand
Antagonist 2.8 Inactive 10.1038/NCOMMS5355 2014-01-22
6TQ7 OX1R OX1 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SB-334867 pubchem gtoplig chembl_ligand
Antagonist 2.7 Inactive 10.1021/acs.jmedchem.9b01787 2020-01-01
7MTB OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Retinal (all-trans) pubchem
Agonist 4.0 Active 10.1038/S41586-021-03721-X 2021-07-07
6PH7 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Nerol pubchem
unknown 2.9 Active 2020-07-01
7EWR GP158 GPR158 C Orphans C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 4.7 Inactive 10.1038/S41467-021-27147-1 2021-12-01
5NX2 GLP1R GLP-1 Glucagon B1 (Secretin) Human BaculovirusSf9Insect 2 chemicals 2 steps vapour diffusionSitting drop 4 chems 8.0-9.0 10°C Truncated protein ag...
Agonist 3.7 Intermediate 10.1038/NATURE22800 2017-06-14
5CGC GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human BaculovirusSf21Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 5.5-6.8 20°C CHEMBL3603915 chembl_ligand pubchem
NAM 3.1 Inactive 10.1021/acs.jmedchem.5b00892 2015-08-12
7T11 SSR2 SST2 Somatostatin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Octreotide
Agonist 2.7 Active 10.1038/S41594-022-00727-5 2022-03-09
8FLQ PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Parathyroid hormone
Agonist 2.6 Active 10.1016/J.STR.2023.04.002 2023-04-26
8G2Y AGRF1 ADGRF1 ADGRF B2 (Adhesion) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A [1-Myristoyl-glycero... pubchem
Agonist 3.4 Active 10.1038/S41467-023-38083-7 2023-05-10
5ZBH NPY1R Y1 Neuropeptide Y A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A BMS-193885 pubchem
Antagonist 3.0 Inactive 10.1038/S41586-018-0046-X 2018-04-25
7VGY MTR1A MT1 Melatonin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2-iodo-melatonin pubchem gtoplig chembl_ligand drugbank
Agonist 3.1 Active 10.1038/S41467-022-28111-3 2022-03-02
2YCZ ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 2 chemicals 2 steps vapour diffusionNA 3 chems 6.9-7.3 NA Iodocyanopindolol pubchem
Antagonist 3.7 Inactive 10.1073/PNAS.1100185108 2011-06-01
7T2H OPRM μ Opioid A (Rhodopsin) Mouse N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A LOFENTANIL chembl_ligand pubchem
Agonist 3.2 Active 10.1038/S41589-022-01208-Y 2022-12-07
7BR3 GNRHR GnRH1 Gonadotrophin-releasing hormone A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A elagolix pubchem gtoplig chembl_ligand drug_central drugbank
Antagonist 2.8 Inactive 10.1038/S41467-020-19109-W 2020-10-07
5IUA AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20 2-(Furan-2-yl)-5-N-[... pubchem
Antagonist 2.2 Inactive 10.1021/acs.jmedchem.6b00653 2016-06-29
5TGZ CNR1 CB1 Cannabinoid A (Rhodopsin) Human Transient_transfectionHEK293FMammalian 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.0-7.4 20°C AM6538 pubchem gtoplig
Antagonist 2.8 Inactive 10.1016/J.CELL.2016.10.004 2016-11-02
6OS0 AGTR1 AT1 Angiotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A angiotensin II pubchem gtoplig chembl_ligand drug_central drugbank pubchem pubchem
Agonist 2.9 Active 10.1126/SCIENCE.AAY9813 2020-02-19
5UIW CCR5 CCR5 Chemokine A (Rhodopsin) Human BaculovirusSf21Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 6.3-6.3 20°C 5P7-CCL5
Antagonist 2.2 Inactive 10.1016/J.IMMUNI.2017.05.002 2017-06-28
7EB2 GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A BHFF pubchem
(-)-baclofen pubchem gtoplig chembl_ligand drugbank drugbank gtoplig pubchem
PAMAgonist 3.5 Active 10.1038/S41586-021-03507-1 2021-05-05
7VVL PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A teriparatide pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem pubchem pubchem pubchem pubchem
Agonist 2.8 Active 10.1016/J.MOLCEL.2022.07.003 2022-08-03
7MTQ GRM2 mGlu2 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A LY341495 pubchem gtoplig chembl_ligand gtoplig
Antagonist 3.7 Inactive 10.1038/S41586-021-03680-3 2021-07-07
7UM5 5HT5A 5-HT5A 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5-CT pubchem gtoplig chembl_ligand
Agonist 2.7 Active 10.1038/S41594-022-00796-6 2022-07-20
3PQR OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionHanging drops 3 chems 5.6-5.6 4°C Retinal (all-trans) pubchem
Agonist 2.9 Active 10.1038/NATURE09789 2011-03-09
7SF8 AGRG1 ADGRG1 ADGRG B2 (Adhesion) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 2.7 Active 10.1038/S41586-022-04575-7 2022-04-27
5L7D SMO SMO Frizzled F (Frizzled) Human Transient_transfectionHEK293S(TetR)-GnTI-Mammalian 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 7 chems 4.0-4.0 20°C N/A N/A 3.2 Inactive 10.1038/NATURE18934 2016-07-20
7EVM GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N-Tert-butyl-6,7-dic... pubchem
Ago-PAM 2.5 Active 10.1038/S41467-021-24058-Z 2021-08-11
7YK7 RL3R2 RXFP4 Relaxin family peptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A DC591053 pubchem gtoplig
Agonist 2.8 Active 10.1038/S41467-023-36182-Z 2023-03-01
2Y04 ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 1 chemicals 1 steps vapour diffusionsitting drops 6 chems 9.0-9.0 4°C levosalbutamol pubchem gtoplig chembl_ligand drug_central drugbank
Agonist (partial) 3.1 Inactive 10.1038/NATURE09746 2011-01-12
7FIH LSHR LH Glycoprotein hormone A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Choriogonadotropin b... gtoplig
Glycoprotein alpha gtoplig
5-Amino-N-(1,1-dimet... pubchem
AgonistAgonistAllosteric agonist 3.2 Active 10.1038/S41586-021-03924-2 2021-09-29
7T10 SSR2 SST2 Somatostatin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SOMATOSTATIN chembl_ligand pubchem
Agonist 2.5 Active 10.1038/S41594-022-00727-5 2022-03-09
7TYF CALCR CT Calcitonin B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A amylin peptide
Agonist 2.2 Active 10.1126/SCIENCE.ABM9609 2022-03-23
7B6W ADA1B α1B Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (+)-cyclazosin pubchem gtoplig chembl_ligand
Inverse agonist 2.9 Inactive 10.1038/s41467-021-27911-3 2022-01-12
7SRS 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Lysergide pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.3 Active 10.1016/J.NEURON.2022.08.006 2022-09-21
7TRY CRFR2 CRF2 Corticotropin-releasing factor B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Urocortin pubchem
Agonist 3.7 Active 10.1038/S41467-022-33851-3 2022-11-09
7EW3 S1PR3 S1P3 Lysophospholipid (S1P) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Sphingosine 1-phosph... pubchem
Agonist 3.1 Active 10.1038/S41422-021-00567-W 2021-09-29
7WUQ AGRG2 ADGRG2 ADGRG B2 (Adhesion) Mouse N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.9 Active 10.1038/S41586-022-04590-8 2022-04-27
7JVR DRD2 D2 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A bromocriptine pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 2.8 Active 10.1016/J.CELL.2021.01.027 2021-02-24
7BB6 V2R V2 Vasopressin and oxytocin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A vasopressin pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 4.2 Active 10.1126/SCIADV.ABG5628 2021-06-02
4ZUD AGTR1 AT1 Angiotensin A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.0-5.0 20°C OLMESARTAN chembl_ligand pubchem
Inverse agonist 2.8 Inactive 10.1074/JBC.M115.689000 2015-10-07
8EFO OPRM μ Opioid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PZM21 pubchem gtoplig chembl_ligand drugbank
Agonist 2.8 Active 10.1016/J.CELL.2022.09.041 2022-11-09
7VUI GP139 GPR139 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A JNJ-63533054 pubchem gtoplig chembl_ligand
Agonist 3.3 Active 10.1038/S41422-021-00591-W 2021-12-29
7Y67 C5AR1 C5a1 Complement peptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A C089
Agonist 2.8 Active 10.1038/S41422-023-00779-2 2023-03-01
7DHR ADRB2 β2 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A LEVISOPRENALINE chembl_ligand chembl_ligand pubchem
Agonist 3.8 Active 10.1093/NSR/NWAA284 2020-12-16
5GLH EDNRB ETB Endothelin A (Rhodopsin) Human BaculovirusSF+Insect 6 chemicals 6 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 6.0-6.0 20°C ENDOTHELIN chembl_ligand pubchem
Agonist 2.8 Inactive 10.1038/nature19319 2016-09-07
6LFM CXCR2 CXCR2 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Interleukin-8 pubchem
Agonist 3.5 Active 10.1038/S41586-020-2492-5 2020-09-02
5EE7 GLR glucagon Glucagon B1 (Secretin) Human Transient_transfectionSf21Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 5.5-6.5 20°C MK-0893 pubchem gtoplig chembl_ligand drugbank
Octaethylene glycol ... pubchem
NAMAntagonist 2.5 Inactive 10.1038/NATURE17414 2016-04-20
6X18 GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL410972 chembl_ligand pubchem pubchem
Agonist 2.1 Active 10.1016/J.MOLCEL.2020.09.020 2020-09-09
7F6G AGTR1 AT1 Angiotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SAR1-AngII
Agonist 2.9 Active 2023-03-29
4QIN SMO SMO Frizzled F (Frizzled) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 6 chems 7.2-7.2 20°C SAG1.5 pubchem
Agonist 2.6 Inactive 10.1038/NCOMMS5355 2014-07-23
6LFO CXCR2 CXCR2 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Interleukin-8 pubchem
Agonist 3.4 Active 10.1038/S41586-020-2492-5 2020-09-02
6IIU TA2R TP Prostanoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ramatroban pubchem gtoplig chembl_ligand drug_central drugbank gtoplig
Antagonist 2.5 Intermediate 10.1038/S41589-018-0170-9 2018-12-19
7EJK ADA2A α2A Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A oxymetazoline pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.4 Active 10.1126/SCIADV.ABJ5347 2022-04-13
7XY6 AA2BR A2B Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A BAY 60-6583 pubchem gtoplig chembl_ligand
Agonist 3.0 Active 10.1126/SCIADV.ADD3709 2023-05-03
7XXI P2Y12 P2Y12 P2Y A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2MeSADP pubchem gtoplig chembl_ligand gtoplig
Agonist 3.0 Active 2023-06-07
7WU4 AGRF1 ADGRF1 ADGRF B2 (Adhesion) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.4 Active 10.1038/S41586-022-04580-W 2022-04-27
7BU7 ADRB1 β1 Adrenoceptors A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL1615159 chembl_ligand pubchem
Agonist 2.6 Active 10.1038/S41422-020-00424-2 2020-12-02
7CFN GPBAR GPBA Bile acid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A INT-777 pubchem
INT-777 pubchem
AgonistPAM 3.0 Active 10.1038/S41586-020-2569-1 2020-09-09
7BW0 GPBAR GPBA Bile acid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.9 Active 10.1038/S41392-020-00262-Z 2020-09-02
8FYN AA2AR A2A Adenosine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ZM-241385 pubchem gtoplig chembl_ligand drugbank
Antagonist 2.0 Inactive 10.1038/S41467-023-36733-4 2023-03-08
8EF6 OPRM μ Opioid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A morphine pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.2 Active 10.1016/J.CELL.2022.09.041 2022-11-09
6ZFZ ACM1 M1 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL3354065 chembl_ligand pubchem
Agonist 2.2 Inactive 10.1016/J.CELL.2021.11.001 2021-10-06
5TZY FFAR1 FFA1 Free fatty acid A (Rhodopsin) Human BaculovirusSf21Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 6.3-6.8 20°C MK-8666 chembl_ligand pubchem
(2S,3R)-3-Cyclopropy... pubchem
AgonistPAM 3.2 Intermediate 10.1038/NSMB.3417 2017-06-07
8IWE TAAR9 TAAR9 A orphans A (Rhodopsin) Mouse N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SPERMIDINE chembl_ligand pubchem
Agonist 3.4 Active 10.1038/S41586-023-06106-4 2023-05-31
8DCR ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Dobutamine pubchem
Agonist 2.6 Active 10.1038/S41467-022-31823-1 2022-07-27
7UM4 5HT5A 5-HT5A 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL3654198 chembl_ligand pubchem
Antagonist 2.8 Inactive 10.1038/S41594-022-00796-6 2022-07-20
6TPG OX2R OX2 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A EMPA pubchem gtoplig chembl_ligand
Antagonist 2.7 Inactive 10.1021/acs.jmedchem.9b01787 2020-01-01
8GUR CNR2 CB2 Cannabinoid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CP55940 pubchem gtoplig chembl_ligand gtoplig
Agonist 2.8 Active 10.1038/S41467-023-37112-9 2023-05-10
5OM1 AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.3-5.4 20°C CHEMBL2024114 chembl_ligand pubchem
Antagonist 2.1 Inactive 10.1038/S41598-017-18570-W 2018-01-17
7F4H MSHR MC1 Melanocortin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL407070 chembl_ligand pubchem pubchem
Agonist 2.7 Active 10.1038/S41422-021-00557-Y 2021-09-08
8DPH 5HT2C 5-HT2C 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A lorcaserin pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.2 Active 10.1016/J.CELREP.2022.111211 2022-08-24
7EO4 S1PR1 S1P1 Lysophospholipid (S1P) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A siponimod pubchem gtoplig chembl_ligand drug_central drugbank
Agonist 2.9 Active 10.1038/S41589-021-00930-3 2022-01-05
7XMT SSR4 SST4 Somatostatin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A J-2156 pubchem gtoplig chembl_ligand
Agonist 2.8 Active 10.1038/S41422-022-00679-X 2022-08-03
3UON ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.5-7.5 19.85°C CHEMBL558910 chembl_ligand pubchem
Antagonist 3.0 Inactive 10.1038/NATURE10753 2012-02-01
7UM7 5HT5A 5-HT5A 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A methylergonovine pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 2.8 Active 10.1038/S41594-022-00796-6 2022-07-20
7MBX CCKAR CCK1 Cholecystokinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL216166 chembl_ligand pubchem
Agonist 2.0 Active 10.1371/JOURNAL.PBIO.3001295 2021-05-26
7E9G GRM2 mGlu2 Metabotropic glutamate C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A JNJ-40411813 pubchem gtoplig chembl_ligand drugbank
eglumegad pubchem gtoplig chembl_ligand gtoplig
PAMAgonist 3.5 Intermediate 10.1038/S41586-021-03495-2 2021-06-23
7MT8 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Retinal (all-trans) pubchem
Agonist 5.8 Active 10.1038/S41586-021-03721-X 2021-07-07
7YXA S1PR5 S1P5 Lysophospholipid (S1P) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4-[6-(2-naphthalen-1... pubchem
Antagonist 2.2 Inactive 10.1038/S41467-022-32447-1 2022-08-10
4UHR AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusHi5Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 4.8-4.8 22°C CGS 21680 pubchem gtoplig chembl_ligand gtoplig
Agonist 2.6 Active 10.1124/mol.114.097360 2015-04-08
7TRS ACM4 M4 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A acetylcholine pubchem gtoplig chembl_ligand drugbank drug_central gtoplig
Agonist 2.8 Active 2023-05-17
7E33 5HT1E 5-HT1E 5-Hydroxytryptamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A BRL-54443 pubchem gtoplig chembl_ligand
Agonist 2.9 Active 10.1038/S41586-021-03376-8 2021-04-14
8E9Z ACM3 M3 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A iperoxo pubchem gtoplig chembl_ligand
Agonist 2.7 Active 10.1038/S41586-022-05489-0 2022-11-30
8FLU PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A PTH
Agonist 2.8 Active 10.1016/J.STR.2023.04.002 2023-04-26
6ORV GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL3950796 chembl_ligand pubchem
Agonist 3.0 Active 10.1038/s41586-019-1902-z 2020-01-08
7XAU SSR2 SST2 Somatostatin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Octreotide
Agonist 3.0 Active 10.1038/S41421-022-00405-2 2022-08-31
3UZC AA2AR A2A Adenosine A (Rhodopsin) Human BaculovirusSf9Insect 1 chemicals 1 steps vapour diffusionsitting drop 6 chems 8.0-8.0 4°C CHEMBL2024114 chembl_ligand pubchem
Antagonist 3.3 Inactive 10.1021/jm201376w 2012-03-21
8IRV DRD5 D5 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A rotigotine pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.1 Active 10.1038/S41422-023-00808-0 2023-06-07
6XBL SMO SMO Frizzled F (Frizzled) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Cholesterol pubchem
SAG1.3 pubchem gtoplig chembl_ligand
AgonistPAM 3.9 Active 10.1038/S41589-020-0646-2 2020-09-30
7F23 DRD1 D1 Dopamine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A dopamine pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.6 Active 10.1126/SCIADV.ABO4158 2022-06-15
5LWE CCR9 CCR9 Chemokine A (Rhodopsin) Human BaculovirusSf21Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 7.9-8.0 20°C vercirnon pubchem gtoplig chembl_ligand drugbank
Allosteric antagonist 2.8 Inactive 10.1038/NATURE20606 2016-12-07
5DSG ACM4 M4 Acetylcholine (muscarinic) A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 5 chems 5.5-8.0 20°C tiotropium pubchem gtoplig chembl_ligand drugbank gtoplig chembl_ligand chembl_ligand
Antagonist 2.6 Inactive 10.1038/NATURE17188 2016-03-16
6ME4 MTR1A MT1 Melatonin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2-iodo-melatonin pubchem gtoplig chembl_ligand drugbank
Agonist 3.2 Inactive 10.1038/S41586-019-1141-3 2019-04-24
6J20 NK1R NK1 Tachykinin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A aprepitant pubchem gtoplig chembl_ligand drugbank drug_central pubchem
Antagonist 2.7 Inactive 10.1038/S41467-019-08568-5 2019-03-06
6QZH CCR7 CCR7 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A SCHEMBL13407377 pubchem
Allosteric antagonist 2.1 Inactive 10.1016/J.CELL.2019.07.028 2019-09-04
4GRV NTR1 NTS1 Neurotensin A (Rhodopsin) Rat BaculovirusTni PRO (Trichoplusia ni) cell linesInsect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 7.0-7.0 20°C JMV431 gtoplig chembl_ligand pubchem
Agonist 2.8 Active 10.1038/NATURE11558 2012-10-17
7M3F CASR CaS Calcium-sensing C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Calcium pubchem
L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem
cinacalcet pubchem gtoplig chembl_ligand drugbank drug_central
AgonistPAMPAM 2.8 Active 10.1038/S41586-021-03691-0 2021-06-30
7L1U OX2R OX2 Orexin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Orexin-A pubchem
Agonist 3.2 Active 10.1038/S41467-021-21087-6 2021-02-10
4X1H OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 1 chemicals 1 steps vapour diffusionsitting drop 3 chems 5.0-6.5 4°C B-Nonylglucoside pubchem
unknown 2.3 Active 10.1016/J.STR.2015.09.015 2015-11-04
6WJC ACM1 M1 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A ENDO-ATROPINE chembl_ligand pubchem
muscarinic toxin 7 gtoplig
AntagonistNAM 2.6 Inactive 10.1126/SCIENCE.AAX2517 2020-07-08
6VCB GLP1R GLP-1 Glucagon B1 (Secretin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A glucagon-like peptid... pubchem gtoplig chembl_ligand gtoplig pubchem pubchem
CHEMBL5197819 chembl_ligand pubchem
AgonistPAM 3.3 Active 10.1038/S41589-020-0589-7 2020-07-22
6DO1 AGTR1 AT1 Angiotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL404594 chembl_ligand pubchem
Agonist 2.9 Active 10.1016/J.CELL.2018.12.006 2019-01-30
7SIL CASR CaS Calcium-sensing C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A tecalcet pubchem gtoplig chembl_ligand
Cyclomethyltryptopha... pubchem
AgonistAgonist 2.7 Active 10.1073/PNAS.2115849118 2022-01-19
8ID9 FFAR4 FFA4 Free fatty acid A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A EPA pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 3.0 Active 10.1126/SCIENCE.ADD6220 2023-03-15
7WUJ AGRG4 ADGRG4 ADGRG B2 (Adhesion) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.3 Active 10.1038/S41586-022-04590-8 2022-04-27
2Y01 ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 1 chemicals 1 steps vapour diffusionsitting drops 6 chems 9.0-9.0 4°C Dobutamine pubchem
Agonist (partial) 2.6 Inactive 10.1038/NATURE09746 2011-03-30
6AKX CCR5 CCR5 Chemokine A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL4238063 chembl_ligand pubchem
Antagonist 2.8 Inactive 10.1021/acs.jmedchem.8b01077 2018-10-24
7W0L APJ apelin Apelin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A (1R,2S)-N-[4-(2,6-di... pubchem
Agonist 3.6 Active 10.1038/S41594-022-00797-5 2022-07-27
2I36 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NANativeBovine 2 chemicals 2 steps vapour diffusionsitting drops 5 chems 7.0-8.0 5°C Apo (no ligand)
Apo (no ligand) 4.1 Inactive 10.1073/PNAS.0608022103 2006-10-17
7WZ4 GPR88 GPR88 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 3.0 Active 10.1038/S41467-022-30081-5 2022-10-26
6IBL ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A arformoterol pubchem gtoplig chembl_ligand drugbank drug_central
Agonist 2.7 Active 10.1038/S41586-020-2419-1 2019-01-09
4LDO ADRB2 β2 Adrenoceptors A (Rhodopsin) Human BaculovirusSf9Insect 2 chemicals 2 steps in meso/LCPlipidic cubic phase (LCP)7.7 MAG 5 chems 6.5-6.5 20°C (-)-adrenaline pubchem gtoplig chembl_ligand drugbank drug_central pubchem
Agonist 3.2 Active 10.1038/NATURE12572 2013-09-25
5YC8 ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N-methyl scopolamine pubchem gtoplig drugbank gtoplig chembl_ligand chembl_ligand
Antagonist 2.5 Inactive 10.1038/S41589-018-0152-Y 2018-11-21
6FFH GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human BaculovirusSf21Insect 1 chemicals 1 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 4 chems 5.5-6.8 20°C fenobam pubchem gtoplig chembl_ligand drugbank gtoplig pubchem pubchem pubchem
NAM 2.7 Inactive 10.1021/ACS.JMEDCHEM.7B01722 2018-03-07
5WIV DRD4 D4 Dopamine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 5.9-6.2 20°C [3H]NEMONAPRIDE chembl_ligand pubchem
Antagonist 2.1 Inactive 10.1126/SCIENCE.AAN5468 2017-10-18
6VJM GABR2 GABAB2 GABAB C (Glutamate) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Apo (no ligand)
Apo (no ligand) 4.0 Inactive 10.1038/S41586-020-2408-4 2020-06-10
7TMW RXFP1 RXFP1 Relaxin family peptide A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A H2 relaxin pubchem
Agonist 3.2 Active 2023-02-15
7UL2 NTR1 NTS1 Neurotensin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A meclinertant pubchem gtoplig chembl_ligand drugbank
Inverse agonist 2.4 Inactive 10.1038/S41594-022-00859-8 2022-06-29
5T1A CCR2 CCR2 Chemokine A (Rhodopsin) Human BaculovirusSf21Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phasemonoolein (9.9 MAG) 5 chems 6.5-6.5 20 °C. CCR2-RA-[R] pubchem gtoplig chembl_ligand
BMS-681 pubchem gtoplig chembl_ligand
Allosteric antagonistAntagonist 2.8 Inactive 10.1038/NATURE20605 2016-12-14
6KO5 GHSR ghrelin Ghrelin A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CHEMBL1956994 chembl_ligand pubchem
Antagonist 3.3 Inactive 10.1038/S41467-020-17554-1 2020-08-12
7VDM MRGX2 MRGPRX2 A orphans A (Rhodopsin) Human N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A substance P pubchem gtoplig chembl_ligand gtoplig gtoplig
Agonist 3.0 Active 10.1038/S41586-021-04077-Y 2021-12-01
3OE8 CXCR4 CXCR4 Chemokine A (Rhodopsin) Human BaculovirusSf9Insect 4 chemicals 4 steps in meso/LCPlipidic cubic phase (LCP)monoolein (9.9 MAG) 6 chems 6.0-6.0 20°C isothiourea-1t pubchem gtoplig chembl_ligand
Antagonist 3.1 Inactive 10.1126/SCIENCE.1194396 2010-10-27
2YCW ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey BaculovirusHi5Insect 2 chemicals 2 steps vapour diffusion