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SEQUENCES
Sequence alignments
Generic residue number tables
Generic variants
Isoforms
SEQUENCE ANALYSIS
Receptor similarity
BLAST (GPCRdb alignment)
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Phylogenetic trees
Similarity matrix (all-to-all)
Site search (by seq. motif)
STRUCTURES
Structure coverage
Structures
Structure models (receptor)
Structure models (ligand complexes)
STRUCTURE ANALYSIS
Structure comparison tool
Structure similarity trees
Structure superposition
Generic residue numbering (PDB)
Structure similarity search
STRUCTURE CONSTRUCTS
Construct/Experiment design
Construct alignments
Construct design tool
Experiment browser
Truncation/Fusion analysis
Truncation sites
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Loop deletions
Mutation analysis
Stabilising mutations
StabMutAnalyser
Mutation substitution matrix
DETERMINANTS & MUTATIONS
Sequence signature tool
State stabilizing mutation design
Drugs
&
ligands
LIGANDS & BIOACTIVITIES
Ligand coverage
Ligands (ChEMBL, GtP, Ki db)
Ligands (by receptor query)
Ligands (by ligand query)
PHYSIOLOGICAL LIGANDS
Physiological ligands (GtP)
DRUGS & AGENTS IN TRIAL
Agents/drugs
Agent/drug page
Agents/drugs by phase I-IV
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Target page
Targets by phase I-IV
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Target selection tool
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Disease page
Disease overview
LIGAND SITES
GPCR-ligand interactions
Site search
Site search (by seq. motif)
Site search (by ligand complex)
LIGAND SITE MUTATIONS
Mutation coverage
Mutations
Mutation design tool
By receptor name
By PDB id
Mutation data submission
GproteinDb
Citing GproteinDb
G protein page
COUPLINGS
Couplings
Datasets
Biosensors
COUPLING ANALYSIS
Coupling selectivity (tree)
Coupling selectivity (Venn)
SEQUENCES
Sequence alignments
Generic residue number tables
STRUCTURES
Structure coverage
Structures
Structure models
STRUCTURE ANALYSIS
Interface interactions & profiling
Structure superposition
DETERMINANTS & MUTATIONS
Coupling determinant mutation design
Interface mutations & chimeras
ArrestinDb
Citing ArrestinDb
Arrestin page
COUPLINGS
Couplings
COUPLING ANALYSIS
Coupling selectivity (tree)
Coupling selectivity (Venn)
SEQUENCES
Sequence alignments
Generic residue number tables
STRUCTURES
Structure coverage
Structures
STRUCTURE ANALYSIS
Interface interactions (single structure)
DETERMINANTS & MUTATIONS
Interface mutations
Biased Signaling Atlas
Citing Biased Signaling Atlas
GUIDELINES
Community guidelines paper
Reference ligand selection
Template to calculate ligand bias factors
BIASED LIGANDS (for transducer family)
Biased ligand coverage
Biased ligands
Ligand bias rank orders
Ligand pathway profiles (Δlog(Emax/EC50))
Ligand pathway profiles (Δlog(Tau/KA))
BIASED LIGANDS (for transducer subtype)
Biased ligand coverage
Biased ligands
Ligand bias rank orders
Ligand pathway profiles (Δlog(Emax/EC50))
Ligand pathway profiles (Δlog(Tau/KA))
PATHWAY-PREFERRING LIGANDS (for transducer family)
Pathway-preferring ligand coverage
Pathway-preferring ligands (pathway ∆Log/(Emax/EC50)
Ligand pathway preference rank orders (Δlog(Emax/EC50))
Ligand pathway profiles (Log(Emax/EC50))
Pathways
Pathway effects
DATA DEPOSITION
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Compound Name
PubChem (ID)
ChEMBL (ID)
DrugBank (ID)
Drug Central (ID)
Guide To Pharmacology (ID)
(-)-adrenaline
(-)-baclofen
(-)-noradrenaline
(-)-pentazocine
(±)-adrenaline
(+)-chlorpheniramine
(+)-sulpiride
(R,R)-TRAMADOL
(S,S)-asenapine
Δ<sup>9</sup>-tetrahydrocannabinol
γ-hydroxybutyrate
5-HT,N-ACETYL
AAA603
AB928
ABALOPARATIDE
abarelix
ABBV-932
acamprosate
acebutolol
ACETOPHENAZINE
acetylcholine
aclidinium
ACRIVASTINE
ACT-1004-1239
ACT-777991
ACTH
ACTH-(1-24)
AD-214
adenosine
AEF0117
afamelanotide
agomelatine
albiglutide
alcaftadine
alfuzosin
alimemazine
alizapride
almotriptan
ALVERINE
alvimopan
AMANTADINE
ambrisentan
Aminophylline
amiodarone
AMISELIMOD
amisulpride
amitriptyline
amoxapine
AMPHETAMINE
Amycretin
anamorelin
angiotensin II
angiotensin-(1-7)
ANPA-0073
ANTAZOLINE
apomorphine
apraclonidine
aprepitant
aprocitentan
arbutamine
ARFORMOTEROL
aripiprazole
asapiprant
ASENAPINE
ASP8062
atenolol
atogepant
atosiban
atrasentan
atropine
atroscine
Atumelnant
avacopan
avdoralimab
AZATADINE
AZD3427
AZD4041
AZD5462
AZD9550
azelastine
azilsartan
azilsartan medoxomil
BACLOFEN
balixafortide
BAMBUTEROL
basimglurant
BAY 3178275
BAY 3375968
BEFIRADOL
befunolol
benperidol
benzatropine
benzhydrocodone
BENZPHETAMINE
bepotastine
beraprost
BETAHISTINE
betaxolol
bethanechol
bethanidine
BGE-105
BI 1820237
bimatoprost
biperiden
bisoprolol
bitolterol
blonanserin
BMB-101
BMS-986278
BMS-986340
BMS-986393
bosentan
bremelanotide
brexpiprazole
brimonidine (UK14304)
bromocriptine
BROMODIPHENHYDRAMINE
BROMOPRIDE
BROMPERIDOL
BROMPHENIRAMINE
bucindolol
BUCLIZINE
bunolol
bupranolol
BUPRENORPHINE
burixafor
buserelin
buspirone
butorphanol
BUTYLSCOPOLAMINE
cabergoline
caffeine
CagriSema
calcitonin (salmon synthetic)
calcitonin human
calcium citrate
candesartan
cangrelor
cannabidiol
carbachol
CARBACHOL
carbetocin
Carboprost
cariprazine
CARTEOLOL
carvedilol
cebranopadol
CELIPROLOL
cenerimod
cetirizine
cetrorelix
cevimeline
CFTX-1554
CHEMBL107979
CHEMBL441920
CHEMBL521606
CHEMBL1077301
CHEMBL1433762
CHEMBL1478530
CHEMBL1740585
CHEMBL2079626
CHLORCYCLIZINE
chlorphenoxamine
chlorpromazine
chlorprothixene
choriogonadotropin alfa
CIDOXEPIN
ciforadenant
cimetidine
cinacalcet
CINITAPRIDE
cinnarizine
Cl-IB-MECA
clazosentan
CLEBOPRIDE
clemastine
clenbuterol
CLF065
clidinium
clomipramine
clonidine
CLOPIDOGREL
CLOTHIAPINE
clozapine
CNTX-0290
CNTX-6016
CNTX-6970
codeine
conivaptan
corifollitropin alfa
CR-6086
crinecerfont
CST-103
CST-2032
CST-2140
CT388
CVL-871
CVN424
CVN766
CYB003
cyclizine
CYCLOBENZAPRINE
CYCLOPENTOLATE
cyproheptadine
DA-1726
danavorexton
DANAZOL
danuglipron
Dapiglutide
dapiprazole
dapoxetine
daridorexant
darifenacin
Darifenacin
dasiglucagon
dAVP
Debio 4126
degarelix
dersimelagon
DESIPRAMINE
desloratadine
DESMOPRESSIN
desmopressin
DEXBROMPHENIRAMINE
dexchlorpheniramine maleate
dexmedetomidine
dextromoramide
DEZOCINE
diamorphine
DIBENZEPIN
dicyclomine
difelikefalin
dihydrocodeine
DIHYDROERGOCRYPTINE
dihydroergotamine
DIMENHYDRINATE
DIMETHINDENE
DIPHEMANIL
diphenhydramine
DIPHENYLPYRALINE
DIPIVEFRIN
dipraglurant
Diprophylline
diquafosol
dobutamine
domperidone
dopamine
dosulepin
Dothiepin
DOTHIEPIN
doxazosin
DOXEPIN
doxepin
doxofylline
DOXYLAMINE
DRONEDARONE
DROPERIDOL
droxidopa
DSP-0038
DSP-2342
DSP-3456
DT-9081
dulaglutide
EBASTINE
ecopipam
Edotreotide Gallium Ga-68
efinopegdutide
Efocipegtrutide
elagolix
eletriptan
elinzanetant
Eltrekibart
eluxadoline
EMEDASTINE
emraclidine
ENDO-ATROPINE
Eneboparatide
EP262
EP547
ephedrine
epinastine
eprosartan
erenumab
ergometrine
ergotamine
ERGOTAMINE
etelcalcetide
ethopropazine
ethylmorphine
etomidate
etrasimod
evocalcet
EXENATIDE
exendin-(9-39)
famotidine
fe 202767
fe 203799
FENFLURAMINE
fenoldopam
fentanyl
FESOTERODINE
fexofenadine
fezolinetant
FIMASARTAN
fingolimod
FLAVOXATE
flibanserin
fluphenazine
fluphenazine decanoate
fluspirilene
FLX475
Forimtamig
formoterol
fosaprepitant
fosnetupitant
frovatriptan
FSH
GANIRELIX ACETATE
GEPIRONE
glasdegib
Glepaglutide
glucagon
glucagon hydrochloride
glycopyrrolate
GONADORELIN
gonadotropin, chorionic
goserelin
GPC201
grapiprant
GS-1811
GSBR-1290
guanabenz
guanfacine
H2 relaxin
haloperidol
HALOPERIDOL DECANOATE
hexocyclium
histamine
histrelin
HR17031
HRS-7535
HRS9531
HTL0039732
hydrocodone
hydromorphone
hydroxyzine
icatibant
idazoxan
iloperidone
ILOPROST
imidafenacin
indacaterol
INDV-2000
ipratropium bromide
irbesartan
ISOETHARINE
isometheptene
isoprenaline
ISOPROPAMIDE
istradefylline
ITOPRIDE
JZP441
ketanserin
KETOBEMIDONE
ketotifen
krp203
labetalol
LADARIXIN
LAFUTIDINE
landiolol
LANREOTIDE
lasmiditan
latanoprost (isopropyl ester)
latanoprostene bunod
lemborexant
leronlimab
leuprolide
LEVOBETAXOLOL
levocabastine
LEVODOPA
LEVOMEPROMAZINE
levomethadyl acetate
levorphanol
levosalbutamol
LH
limaprost
linzagolix
liraglutide
lisdexamfetamine
lisuride
lixisenatide
lofexidine
loperamide
loratadine
losartan
loxapine
LTSE-2578
Lu AF28996
LUMATEPERONE
lurasidone
LY2456302
macimorelin
macitentan
maraviroc
Maridebart cafraglutide
MASUPIRDINE
MAVOGLURANT
mavorixafor
Mazdutide
MECLIZINE
MEDI0618
mepenzolic acid
mephentermine
MEPTAZINOL
mepyramine
MEQUITAZINE
mesdopetam
mesoridazine
METARAMINOL
methacholine
Methadone,(R)(-)
METHANTHELINE
Methdilazine
METHIXENE
methoxamine
methoxyphenamine
METHYLDOPA
methylergonovine
METHYLHOMATROPINE
methylnaltrexone
METHYSERGIDE
methysergide
metipranolol
metoclopramide
metoprolol
mevidalen
mianserin
MIDODRINE
mirabegron
mirtazapine
misoprostol (methyl ester)
mizolastine
mogamulizumab
molindone
montelukast
morphine
mosapride
motixafortide
MOXISYLYTE
moxonidine
N-methyl scopolamine
nabilone
nabiximols
nadolol
nafarelin
NAFTOPIDIL
nalbuphine
naldemedine
nalmefene
naloxegol
naloxone
naltrexone
naphazoline
naratriptan
NBI-1117567
NBI-1117568
NBI-1117569
NBI-1117570
nebivolol
nedocromil
netupitant
NICERGOLINE
nimacimab
nizatidine
nly-01
NMRA-140
NN9541
nomacopan
nortriptyline
NXE0048149
OB-002
octreotide
olanzapine
OLICERIDINE
olmesartan
olodaterol
OLOPATADINE
OMIDENEPAG ISOPROPYL
ONO-2808
ONO-4578
OPC-131461
orforglipron
orn-0829 hydrate
ORPHENADRINE
ORVEPITANT
ORX750
OXATOMIDE
OXEDRINE
OXPRENOLOL
oxtriphylline
oxybutynin
oxymetazoline
OXYMORPHONE
OXYPHENCYCLIMINE
oxyphenonium
oxytocin
ozanimod
PALIPERIDONE
paliperidone palmitate
PALTUSOTINE
parathyroid hormone
PASIREOTIDE
PBF-509
pbf-680
pbf-999
Pemvidutide
PENBUTOLOL
pentoxifylline
periciazine
perphenazine
pethidine
Petrelintide
PF-06835375
PF-06954522
PF-07054894
PF-07258669
PGE<sub>1</sub>
PGE<sub>2</sub>
PGI<sub>2</sub>
PHENDIMETRAZINE
PHENINDAMINE
PHENIRAMINE
phenoxybenzamine
phentolamine
phenylephrine
pholcodine
piclidenoson
PICOTAMIDE
pilocarpine
pimavanserin
pimozide
pindolol
pipamperone
pirbuterol
pirenzepine
piribedil
piromelatine
pitolisant
pizotifen
plerixafor
ponesimod
pramipexole
pramlintide
pranlukast
PRASUGREL
prazosin
procaterol
procaterol
prochlorperazine
PROCYCLIDINE
promethazine
propafenone
propantheline
PROPIVERINE
PROPRANOLOL
prucalopride
PSEUDOEPHEDRINE
PSILOCYBINE
quetiapine
QUINAGOLIDE
R-cevimeline
R-tirzepatide
RALINEPAG
ramatroban
ramelteon
RANITIDINE
RAUWOLFIA SERPENTINA
regadenoson
relenopride
relugolix
REMIFENTANIL
reparixin
reproterol
Retatrutide
revefenacin
RIMEGEPANT
rimiterol
risperidone
rizatriptan
ROCURONIUM
rolapitant
ropinirole
rotigotine
rovatirelin
rupatadine
S-531011
S-selatogrel
salbutamol
salmeterol
samidorphan
SAR445611
saridegib
sarpogrelate
SCO-094
SCO-240
SCO-267
scopolamine
SCOPOLAMINE
SCOPOLAMINE
SECRETIN
selatogrel
selexipag
seltorexant
semaglutide
SERATRODAST
setmelanotide
SHR7280
silodosin
siponimod
sodium oxybate
sofpironium
solifenacin
sonidegib
sotalol
sovateltide
sparsentan
SRX246
sufentanil
SULPIRIDE,(-)
sumatriptan
suramin
survodutide
SUVN-G3031
suvorexant
SX-682
tafluprost
taladegib
talquetamab
tamsulosin
tapentadol
tasimelteon
tavapadon
teduglutide
telmisartan
terazosin
terbutaline
teriparatide
teriparatide acetate hydrate
TERLIPRESSIN
tesamorelin
TETRAHYDROZOLINE
teverelix
theophylline
THIETHYLPERAZINE
THIOPROPERAZINE
thiothixene
thonzylamine
TIANEPTINE
TIAPRIDE
ticagrelor
TICLOPIDINE
timolol
tiotropium
tizanidine
TMP-301
tolterodine
tolvaptan
tradipitant
tramadol
travoprost
trazodone
treprostinil
TRH
TRH
TRIDIHEXETHYL
trifluoperazine
TRIFLUPROMAZINE
trihexyphenidyl
TRIMEBUTINE
TRIMIPRAMINE
tripelennamine
triprolidine
triptorelin
tropicamide
TROSPIUM
TRV045
TRV250
TRV734
TT-702
TT-816
TULOBUTEROL
ubrogepant
ulotaront
umeclidinium
valsartan
vapreotide
Vasoactive intestinal polypeptide
vasopressin
vibegron
vicagrel
vilanterol
vilazodone
vismodegib
volagidemab
Volenrelaxin
vorapaxar
vortioxetine
xanomeline
xylometazoline
YF-476
YH25724
yohimbine
zafirlukast
ZAVEGEPANT
zelnecirnon
zibotentan
ziprasidone
zolmitriptan
ZUCLOPENTHIXOL
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Target
Indication
Agent/Drug
Gene
Protein
Receptor family
Ligand type
Class
Indication name
ICD11
ATC
Association score
Phase
Approved