GPCRdb release notes

Dec. 20, 2024
  • GAIN domain segments for Class B2 (Adhesion) GPCRs
  • New structures
  • Minor bug and performance fixes
Dec. 3, 2024
  • New structures
  • Minor bug and performance fixes
Nov. 6, 2024
July 16, 2024
  • New structures
  • Minor bug and performance fixes
Feb. 12, 2024
  • New Structure superposition workflow for G protein α subunits (experimental structures and models) with custom segment and residue selection
  • Chimera mapping fixed for structures with Gq chimeras
  • New structures
  • Minor bug and performance fixes
Oct. 25, 2023
Sept. 22, 2023
  • New AlphaFold2-Multimer GPCR - G protein complex models
  • Coupling data added to complex models table
  • New refined complex structures
  • New refined complex structures
  • Updated interface interaction matrix with refined structures and AlphaFold2-Multimer models
  • New visualisation modes for GPCR - G protein interactions (biflare plot, matrix, 3D view)
  • Coupling interactions between residues with no generic residue number added
  • Receptor sequences updated to latest UniProt canonical sequence
  • Gα segment names changed to include domain annotation (e.g. from H5 to G.H5)
  • API calls added for G protein data
  • New structures
  • Minor bug and performance fixes
June 19, 2023
  • Drugs, targets and indications page layout updated
  • 54 new structures
  • All PDB files updated to their most recent version
  • G protein chimera mapping improved
  • Improved GPCR - G protein interface interactions
  • Interaction bug fixes
  • Hydrogen atoms removed from AlphaFold models
  • Minor bug and performance fixes
March 9, 2023
  • 195 new structures added (up until December 2022)
  • New automated structure segment annotation based on DSSP and custom rules
  • New ligand interaction calculation process using RDKit for higher precision and accuracy
  • Van der Waals interactions added
  • Class C activation state reverted to author based annotation instead of degree active calculation
  • New API calls for ligand data
  • GPCR - G protein interface interactions figures are now downloadable
  • Structure annotation fixes
  • Minor bug and performance fixes
Nov. 3, 2022
Sept. 9, 2022
July 28, 2022
June 23, 2022
April 30, 2022
  • Updated GPCR and G protein structures
  • Updated GPCR ligand and bioactivity data to ChEMBL v30
  • Updated GPCR homology and refined structure models
  • Minor bug and performance fixes
March 30, 2022
  • Release of the new Biased Signaling resource
    • Bias calculations according to the recently published Community Guidelines for GPCR Ligand Bias
    • In-depth browsing and plotting of biased signaling data for individual receptors on transducer family and subtype level
    • Visualisation of the trends in the signaling data via the statistics pages
    • Annotation of endogenous ligands via the Guide to Pharmacology for identifying physiology-biased ligands
    • Comparison of receptor-signaling profiles between any ligand with signaling data for a given receptor
  • Revamped ligand handling in GPCRdb
    • Improved ligand identification, processing, curation, integration, and crosslinking
    • Updated GPCR ligand and bioactivity data from ChEMBL
    • Updated ligand vendor data from PubChem
    • Linking ligands to external sources (Guide to Pharmacology, ChEMBL, PubChem, Drug Central, and DrugBank)
  • Updated GPCR and G protein structures
  • Updated GPCR homology and refined structure models
  • Minor bug and performance fixes
Jan. 31, 2022
  • Updated GPCR and G protein structures
  • Updated GPCR-G protein complex structure models
  • Updated GPCR homology and refined structure models
  • Minor bug and performance fixes
Dec. 23, 2021
  • Updated GPCR and G protein structures
  • Minor bug and performance fixes
Nov. 4, 2021
Oct. 7, 2021
Sept. 10, 2021
July 20, 2021
June 14, 2021
May 14, 2021
April 14, 2021
March 18, 2021
  • Improved tree visualizations on all statistics pages
  • Updated GPCR and G protein structures
  • Updated GPCR homology and refined structure models
  • Added community-contributed mutation data
  • Updated references
  • Minor bug and performance fixes
Feb. 11, 2021
  • Improved structure download and superpositioning workflow
  • Updated GPCR structures
  • Updated GPCR homology and refined structure models
  • Minor bug and performance fixes
Jan. 12, 2021
Dec. 7, 2020
Nov. 4, 2020
Oct. 8, 2020
Sept. 3, 2020
  • Updated GPCR annotated structures and it's encompassing browser and accordingly updated statistics
  • Updated GPCR homology and refined structure models
  • Updated GPCR-G protein complex structure models
  • Updated ligand database
  • New and faster phylogenetic tree tool
  • New easy citation tool
  • New join us tool
  • Updated menu layout
Oct. 25, 2019 Recent additions (not reported here earlier)
March 11, 2019
Jan. 21, 2019
April 5, 2018
Nov. 15, 2017
July 25, 2017
May 17, 2017
Sept. 21, 2016
May 18, 2016
  • New Mutation Design Tool
  • More mutant data
  • Updated alignments for all proteins
  • Homology models (Class A)
  • B2-adrenoceptor - Gs protein interface
  • G protein assocation statistics
  • Import/export of receptor selections
  • Import/export of segment selections
Sept. 30, 2015
  • Re-designed interface
  • NC-IUPHAR nomenclature
  • Updated alignments for all proteins
  • New web services
  • Site search from PDB files
  • Improved mutant browser
  • More mutant data
  • Ligand interaction diagrams
  • BLAST search