GPCRdb

Excel (underlying datasets)

See the Datasets and Biosensors pages for more information about the underlying data.

Receptor						Source					Ligand		No. supporting datasets				Selectivity		Family rank orders				% of 1' G protein family				Quantitative values						% of 1' G protein subtype																Quantitative values
Uniprot	GtoPdb (IUPHAR)	GPCRdb	Rec. family	Cl	Other protein	Lab	Biosensor	Down- stream steps	#Gprots tested	Ref	Name	Phys. / Surr.	Gs	Gi/o	Gq/11	G12/13	Primary family	#Fam	Gs	Gi/o	Gq/11	G12/13	Gs	Gi/o	Gq/11	G12/13	Parameter	Gs	Gi/o	Gq/11	G12/13	Primary subtype	GsL	GsS	Golf	Gi1	Gi2	Gi3	Ggust	Gz	GoA	GoB	Gq	G11	G14	G15	G12	G13	Parameter	GsL	GsS	Golf	Gi1	Gi2	Gi3	Ggust	Gz	GoA	GoB	Gq	G11	G14	G15	G12	G13

5HT1A	5-HT_1A		5-Hydroxytryptamine	A	-	Bouvier	GEMTA	3	12		5-hydroxytryptamine	Phys	-	3	2	-	Gi/o	2	nc	1'	2'	nc	0	100	81	0	log(Emax/EC50)	0.0	8.3	6.7	0.0	GoB	0	-	-	92	85	-	-	96	97	100	0	0	65	81	0	0	log(Emax/EC50)	0.0	-	-	7.6	7.0	-	-	7.9	8.0	8.3	0.0	0.0	5.4	6.7	0.0	0.0
5HT1A	5-HT_1A		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	3	2	-	Gi/o	2	nc	1'	2'	nc	0	100	1	0	Activation rate (s^-1)	0.0	7.4	0.1	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	1	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	7.4	-	0.0	-	-	0.1	-	0.0
5HT1A	5-HT_1A		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	2	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1A	5-HT_1A		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	2	-	Gi/o	2	nc	1'	2'	nc	0	100	41	0	-	-	-	-	-	GoB	0	-	-	92	85	-	-	96	98	100	0	0	65	41	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1B	5-HT_1B		5-Hydroxytryptamine	A	-	Bouvier	GEMTA	3	12		5-hydroxytryptamine	Phys	-	3	1	-	Gi/o	2	nc	1'	2'	nc	0	100	71	0	log(Emax/EC50)	0.0	8.7	6.2	0.0	GoB	0	-	-	99	98	-	-	93	98	100	0	0	0	71	0	0	log(Emax/EC50)	0.0	-	-	8.6	8.6	-	-	8.1	8.5	8.7	0.0	0.0	0.0	6.2	0.0	0.0
5HT1B	5-HT_1B		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	3	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.4	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.4	-	0.0	-	-	0.0	-	0.0
5HT1B	5-HT_1B		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	1	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1B	5-HT_1B		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	1	-	Gi/o	2	nc	1'	2'	nc	0	100	36	0	-	-	-	-	-	GoB	0	-	-	99	98	-	-	93	99	100	0	0	0	36	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1D	5-HT_1D		5-Hydroxytryptamine	A	-	Bouvier	GEMTA	3	12		5-hydroxytryptamine	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	log(Emax/EC50)	0.0	8.6	0.0	0.0	Gi1	0	-	-	100	100	-	-	43	94	94	0	0	0	0	0	0	log(Emax/EC50)	0.0	-	-	8.6	8.6	-	-	3.7	8.1	8.1	0.0	0.0	0.0	0.0	0.0	0.0
5HT1D	5-HT_1D		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.2	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.0	-	0.0
5HT1D	5-HT_1D		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	3	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1D	5-HT_1D		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gi1	0	-	-	100	100	-	-	43	97	94	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1E	5-HT_1E		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	2	-	-	Gi/o	1	nc	1'	2'	nc	0	100	2	0	Activation rate (s^-1)	0.0	0.9	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	2	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.9	-	0.0	-	-	0.0	-	0.0
5HT1E	5-HT_1E		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1E	5-HT_1E		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	2	nc	1'	2'	nc	0	100	2	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	2	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1F	5-HT_1F		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.4	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.4	-	0.0	-	-	0.0	-	0.0
5HT1F	5-HT_1F		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1F	5-HT_1F		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	Bouvier	GEMTA	3	12		5-hydroxytryptamine	Phys	-	3	5	-	Gq/11	2	nc	2'	1'	nc	0	77	100	0	log(Emax/EC50)	0.0	6.7	8.6	0.0	G14	0	-	-	68	63	-	-	77	62	66	98	99	100	93	0	0	log(Emax/EC50)	0.0	-	-	5.9	5.5	-	-	6.7	5.4	5.7	8.4	8.5	8.6	8.0	0.0	0.0
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	Lambert	RGB-GDP	0	6	-	5-hydroxytryptamine	Phys	-	3	5	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Efficacy	0.00	0.00	0.01	0.00	Gq	0	-	-	0	-	-	-	-	-	-	100	-	-	-	0	-	Efficacy	0.00	-	-	0.00	-	-	-	-	-	-	0.01	-	-	-	0.00	-
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	3	5	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	3	5	-	Gq/11	2	nc	2'	1'	nc	0	12	100	0	Activation rate (s^-1)	0.0	0.1	0.5	0.0	Gq	0	-	-	-	-	-	-	-	12	-	100	-	-	17	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.5	-	-	0.1	-	0.0
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	Inoue	TGF𝛼	5	1		5-hydroxytryptamine	Phys	-	3	5	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.2	-	-	-	-	-
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	5	-	Gq/11	2	-	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	5	-	Gq/11	2	nc	2'	1'	nc	0	22	75	0	-	-	-	-	-	G14	0	-	-	23	63	-	-	77	37	66	74	99	100	55	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT2B	5-HT_2B		5-Hydroxytryptamine	A	-	Bouvier	GEMTA	3	12		5-hydroxytryptamine	Phys	-	1	4	-	Gq/11	2	nc	2'	1'	nc	0	99	100	0	log(Emax/EC50)	0.0	7.7	7.8	0.0	Gq	0	-	-	0	0	-	-	99	0	85	100	100	97	90	0	0	log(Emax/EC50)	0.0	-	-	0.0	0.0	-	-	7.7	0.0	6.6	7.8	7.8	7.5	7.0	0.0	0.0
5HT2B	5-HT_2B		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	1	4	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Activation rate (s^-1)	0.0	0.0	0.1	0.0	Gq	0	-	-	-	-	-	-	-	0	-	100	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.0	-	0.1	-	-	0.0	-	0.0
5HT2B	5-HT_2B		5-Hydroxytryptamine	A	-	Inoue	TGF𝛼	5	1		5-hydroxytryptamine	Phys	-	1	4	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.6	-	-	-	-	-
5HT2B	5-HT_2B		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	4	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT2B	5-HT_2B		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	4	-	Gq/11	2	nc	2'	1'	nc	0	50	100	0	-	-	-	-	-	Gq	0	-	-	0	0	-	-	99	0	85	100	100	97	45	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT2C	5-HT_2C		5-Hydroxytryptamine	A	-	Bouvier	GEMTA	3	12		5-hydroxytryptamine	Phys	-	3	4	1	Gi/o	3	nc	1'	2'	3'	0	100	97	84	log(Emax/EC50)	0.0	8.7	8.4	7.3	Gz	0	-	-	79	77	-	-	100	78	84	0	0	0	97	84	84	log(Emax/EC50)	0.0	-	-	6.9	6.7	-	-	8.7	6.8	7.3	0.0	0.0	0.0	8.4	7.3	7.3
5HT2C	5-HT_2C		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	3	4	1	Gq/11	2	nc	2'	1'	3'	0	1	100	0	Activation rate (s^-1)	0.0	0.1	10.3	0.0	Gq	0	-	-	-	-	-	-	-	1	-	100	-	-	1	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	10.3	-	-	0.1	-	0.0
5HT2C	5-HT_2C		5-Hydroxytryptamine	A	-	Inoue	TGF𝛼	5	1		5-hydroxytryptamine	Phys	-	3	4	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.4	-	-	-	-	-
5HT2C	5-HT_2C		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	4	1	Gq/11	2	-	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT2C	5-HT_2C		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	4	1	Gq/11	3	nc	2'	1'	3'	0	50	98	42	-	-	-	-	-	Gz	0	-	-	79	77	-	-	100	40	84	50	0	0	49	84	42	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT4R	5-HT₄		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	2	1	1	2	Gs	4	1'	3'	2'	4'	100	4	9	2	Activation rate (s^-1)	4.2	0.2	0.4	0.1	GsL	100	-	-	-	-	-	-	-	4	-	0	-	-	9	-	2	Activation rate (s^-1)	4.2	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.4	-	0.1
5HT4R	5-HT₄		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	1	1	2	Gs	2	1'	-	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT4R	5-HT₄		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	2	1	1	2	Gs	4	1'	3'	2'	4'	100	4	9	2	-	-	-	-	-	GsL	100	-	-	-	-	-	-	-	4	-	0	-	-	9	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT5A	5-HT_5A		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.1	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.0	-	-	0.0	-	0.0
5HT5A	5-HT_5A		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	1	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT5A	5-HT_5A		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT6R	5-HT₆		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	2	-	2	1	Gs	3	1'	nc	2'	3'	100	0	26	11	Activation rate (s^-1)	0.9	0.0	0.2	0.1	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	26	-	11	Activation rate (s^-1)	0.9	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.2	-	0.1
5HT6R	5-HT₆		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	-	2	1	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT6R	5-HT₆		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	2	-	2	1	Gs	3	1'	nc	2'	3'	100	0	26	11	-	-	-	-	-	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	26	-	11	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT7R	5-HT₇		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	3	1	1	-	Gs	2	1'	2'	nc	nc	100	22	0	0	Activation rate (s^-1)	0.9	0.2	0.0	0.0	GsL	100	-	-	-	-	-	-	-	22	-	0	-	-	0	-	0	Activation rate (s^-1)	0.9	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.0	-	0.0
5HT7R	5-HT₇		5-Hydroxytryptamine	A	-	Roth	TRUPATH	1	15		5-hydroxytryptamine	Phys	3	1	1	-	Gs	1	1'	nc	nc	nc	100	0	0	0	log(Emax/EC50)	100.0	0.0	0.0	0.0	GsS	99	100	99	0	0	0	0	0	0	0	0	0	-	0	0	0	log(Emax/EC50)	7.8	7.9	7.8	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-	0.0	0.0	0.0
5HT7R	5-HT₇		5-Hydroxytryptamine	A	-	Inoue	TGF𝛼	5	1		5-hydroxytryptamine	Phys	3	1	1	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.8	-	-	-	-	-
5HT7R	5-HT₇		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	1	1	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT7R	5-HT₇		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	3	1	1	-	Gs	2	1'	2'	nc	nc	100	11	0	0	-	-	-	-	-	GsL	100	100	99	0	0	0	0	0	11	0	0	0	-	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM1	M₁		Acetylcholine (muscarinic)	A	-	Bouvier	GEMTA	3	12		acetylcholine	Phys	1	2	4	-	Gq/11	3	2'	3'	1'	nc	75	68	100	0	log(Emax/EC50)	5.8	5.3	7.8	0.0	G11	75	-	-	64	59	-	-	68	57	61	97	100	98	99	0	0	log(Emax/EC50)	5.8	-	-	4.9	4.6	-	-	5.3	4.4	4.8	7.5	7.8	7.6	7.6	0.0	0.0
ACM1	M₁		Acetylcholine (muscarinic)	A	-	Martemyanov	FreeGβγ-Nluc	2	5		acetylcholine	Phys	1	2	4	-	Gq/11	2	nc	2'	1'	nc	0	5	100	0	Activation rate (s^-1)	0.0	0.1	2.4	0.0	Gq	0	-	-	-	-	-	-	-	5	-	100	-	-	55	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	2.4	-	-	1.3	-	0.0
ACM1	M₁		Acetylcholine (muscarinic)	A	-	Inoue	TGF𝛼	5	1		acetylcholine	Phys	1	2	4	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.5	-	-	-	-	-
ACM1	M₁		Acetylcholine (muscarinic)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	2	4	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM1	M₁		Acetylcholine (muscarinic)	A	-	GproteinDb	merged data	-	-	-	-	-	1	2	4	-	Gq/11	3	2'	3'	1'	nc	38	36	100	0	-	-	-	-	-	G11	38	-	-	64	59	-	-	68	31	61	98	100	98	77	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM2	M₂		Acetylcholine (muscarinic)	A	-	Bouvier	GEMTA	3	12		acetylcholine	Phys	2	3	2	-	Gi/o	3	3'	1'	2'	nc	65	100	86	0	log(Emax/EC50)	5.6	8.6	7.4	0.0	GoB	65	-	-	92	88	-	-	92	94	100	0	0	52	86	0	0	log(Emax/EC50)	5.6	-	-	7.9	7.6	-	-	8.0	8.1	8.6	0.0	0.0	4.5	7.4	0.0	0.0
ACM2	M₂		Acetylcholine (muscarinic)	A	-	Martemyanov	FreeGβγ-Nluc	2	5		acetylcholine	Phys	2	3	2	-	Gi/o	1	nc	1'	2'	nc	0	100	2	0	Activation rate (s^-1)	0.0	1.3	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	2	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.3	-	0.0	-	-	0.0	-	0.0
ACM2	M₂		Acetylcholine (muscarinic)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	2	3	2	-	Gi/o	3	2'	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM2	M₂		Acetylcholine (muscarinic)	A	-	GproteinDb	merged data	-	-	-	-	-	2	3	2	-	Gi/o	3	3'	1'	2'	nc	32	100	44	0	-	-	-	-	-	GoB	32	-	-	92	88	-	-	92	97	100	0	0	52	44	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD2	D₂		Dopamine	A	-	Bouvier	GEMTA	3	12		dopamine	Phys	1	5	2	-	Gi/o	2	nc	1'	2'	nc	0	100	61	0	log(Emax/EC50)	0.0	8.6	5.3	0.0	GoB	0	-	-	93	87	-	-	86	93	100	0	0	0	61	0	0	log(Emax/EC50)	0.0	-	-	8.0	7.5	-	-	7.4	8.0	8.6	0.0	0.0	0.0	5.3	0.0	0.0
DRD2	D₂		Dopamine	A	-	Lambert	RGB-GDP	0	6		dopamine	Phys	1	5	2	-	Gi/o	3	3'	1'	2'	nc	7	100	8	0	Efficacy	0.01	0.14	0.01	0.00	Gi1	7	-	-	100	-	-	-	-	-	-	8	-	-	-	0	-	Efficacy	0.01	-	-	0.14	-	-	-	-	-	-	0.01	-	-	-	0.00	-
DRD2	D₂		Dopamine	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	1	5	2	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.03	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.03	-	-	-	-	-	-	0.00	-	-	-	0.00	-
DRD2	D₂		Dopamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		dopamine	Phys	1	5	2	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	4.2	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	4.2	-	0.0	-	-	0.0	-	0.0
DRD2	D₂		Dopamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	5	2	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD2	D₂		Dopamine	A	-	GproteinDb	merged data	-	-	-	-	-	1	5	2	-	Gi/o	3	3'	1'	2'	nc	2	100	17	0	-	-	-	-	-	GoB	2	-	-	98	87	-	-	86	96	100	2	0	0	30	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM3	M₃		Acetylcholine (muscarinic)	A	-	Bouvier	GEMTA	3	12		acetylcholine	Phys	1	3	6	-	Gq/11	2	nc	2'	1'	nc	0	72	100	0	log(Emax/EC50)	0.0	5.4	7.6	0.0	G15	0	-	-	72	65	-	-	67	67	69	94	97	97	100	0	0	log(Emax/EC50)	0.0	-	-	5.4	4.9	-	-	5.1	5.0	5.2	7.1	7.4	7.3	7.6	0.0	0.0
ACM3	M₃		Acetylcholine (muscarinic)	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	1	3	6	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Econstitutive	0.00	0.00	0.02	0.00	Gq	0	-	-	0	-	-	-	-	-	-	100	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.02	-	-	-	0.00	-
ACM3	M₃		Acetylcholine (muscarinic)	A	-	Lambert	RGB-GDP	0	6		acetylcholine	Phys	1	3	6	-	Gq/11	3	3'	2'	1'	nc	15	67	100	0	Efficacy	0.02	0.09	0.13	0.00	Gq	15	-	-	67	-	-	-	-	-	-	100	-	-	-	0	-	Efficacy	0.02	-	-	0.09	-	-	-	-	-	-	0.13	-	-	-	0.00	-
ACM3	M₃		Acetylcholine (muscarinic)	A	-	Martemyanov	FreeGβγ-Nluc	2	5		acetylcholine	Phys	1	3	6	-	Gq/11	2	nc	2'	1'	nc	0	13	100	0	Activation rate (s^-1)	0.0	0.6	5.0	0.0	Gq	0	-	-	-	-	-	-	-	13	-	100	-	-	49	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.6	-	5.0	-	-	2.5	-	0.0
ACM3	M₃		Acetylcholine (muscarinic)	A	-	Inoue	TGF𝛼	5	1		acetylcholine	Phys	1	3	6	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.1	-	-	-	-	-
ACM3	M₃		Acetylcholine (muscarinic)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	3	6	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM3	M₃		Acetylcholine (muscarinic)	A	-	GproteinDb	merged data	-	-	-	-	-	1	3	6	-	Gq/11	3	3'	2'	1'	nc	4	38	100	0	-	-	-	-	-	Gq	4	-	-	46	65	-	-	67	40	69	98	97	97	74	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM4	M₄		Acetylcholine (muscarinic)	A	-	Bouvier	GEMTA	3	12		acetylcholine	Phys	1	5	3	1	Gi/o	2	nc	1'	2'	nc	0	100	78	0	log(Emax/EC50)	0.0	8.7	6.9	0.0	GoB	0	-	-	93	94	-	-	90	92	100	52	0	56	78	0	0	log(Emax/EC50)	0.0	-	-	8.1	8.2	-	-	7.9	8.0	8.7	4.6	0.0	4.9	6.9	0.0	0.0
ACM4	M₄		Acetylcholine (muscarinic)	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	1	5	3	1	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.14	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.14	-	-	-	-	-	-	0.00	-	-	-	0.00	-
ACM4	M₄		Acetylcholine (muscarinic)	A	-	Lambert	RGB-GDP	0	6		acetylcholine	Phys	1	5	3	1	Gi/o	4	2'	1'	4'	3'	16	100	9	11	Efficacy	0.06	0.39	0.04	0.04	Gi1	16	-	-	100	-	-	-	-	-	-	9	-	-	-	11	-	Efficacy	0.06	-	-	0.39	-	-	-	-	-	-	0.04	-	-	-	0.04	-
ACM4	M₄		Acetylcholine (muscarinic)	A	-	Martemyanov	FreeGβγ-Nluc	2	5		acetylcholine	Phys	1	5	3	1	Gi/o	2	nc	1'	2'	nc	0	100	3	0	Activation rate (s^-1)	0.0	5.8	0.2	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	3	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	5.8	-	0.0	-	-	0.2	-	0.0
ACM4	M₄		Acetylcholine (muscarinic)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	5	3	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM4	M₄		Acetylcholine (muscarinic)	A	-	GproteinDb	merged data	-	-	-	-	-	1	5	3	1	Gi/o	4	3'	1'	2'	4'	4	100	22	3	-	-	-	-	-	GoB	4	-	-	98	94	-	-	90	96	100	15	0	56	40	4	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM5	M₅		Acetylcholine (muscarinic)	A	-	Martemyanov	FreeGβγ-Nluc	2	5		acetylcholine	Phys	-	1	3	-	Gq/11	2	nc	2'	1'	nc	0	6	100	0	Activation rate (s^-1)	0.0	0.2	2.8	0.0	Gq	0	-	-	-	-	-	-	-	6	-	100	-	-	53	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.2	-	2.8	-	-	1.5	-	0.0
ACM5	M₅		Acetylcholine (muscarinic)	A	-	Inoue	TGF𝛼	5	1		acetylcholine	Phys	-	1	3	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.1	-	-	-	-	-
ACM5	M₅		Acetylcholine (muscarinic)	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	3	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM5	M₅		Acetylcholine (muscarinic)	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	3	-	Gq/11	2	nc	2'	1'	nc	0	6	100	0	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	6	-	100	-	-	53	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA1A	α_1A		Adrenoceptors	A	-	Bouvier	GEMTA	3	12		noradrenaline	Phys	2	1	4	1	Gq/11	3	2'	3'	1'	nc	85	78	100	0	log(Emax/EC50)	6.6	6.1	7.8	0.0	G15	85	-	-	76	0	-	-	0	78	0	97	97	85	100	0	0	log(Emax/EC50)	6.6	-	-	5.9	0.0	-	-	0.0	6.1	0.0	7.6	7.5	6.6	7.8	0.0	0.0
ADA1A	α_1A		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	2	1	4	1	Gq/11	2	2'	nc	1'	nc	21	0	100	0	Activation rate (s^-1)	0.3	0.0	1.3	0.0	Gq	21	-	-	-	-	-	-	-	0	-	100	-	-	29	-	0	Activation rate (s^-1)	0.3	-	-	-	-	-	-	-	0.0	-	1.3	-	-	0.4	-	0.0
ADA1A	α_1A		Adrenoceptors	A	-	Inoue	TGF𝛼	5	1		(-)-noradrenaline	Phys	2	1	4	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.0	-	-	-	-	-
ADA1A	α_1A		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	1	4	1	Gq/11	2	-	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA1A	α_1A		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	2	1	4	1	Gq/11	3	2'	3'	1'	nc	53	39	100	0	-	-	-	-	-	Gq	53	-	-	76	0	-	-	0	39	0	98	97	85	64	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA1B	α_1B		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	-	-	3	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Activation rate (s^-1)	0.0	0.0	0.5	0.0	G15	0	-	-	-	-	-	-	-	0	-	88	-	-	100	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.0	-	0.4	-	-	0.5	-	0.0
ADA1B	α_1B		Adrenoceptors	A	-	Inoue	TGF𝛼	5	1		(-)-noradrenaline	Phys	-	-	3	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.1	-	-	-	-	-
ADA1B	α_1B		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	3	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA1B	α_1B		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	3	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	-	-	-	-	-	G15	0	-	-	-	-	-	-	-	0	-	88	-	-	100	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA1D	α_1D		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	-	-	2	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Activation rate (s^-1)	0.0	0.0	0.2	0.0	Gq	0	-	-	-	-	-	-	-	0	-	100	-	-	25	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.0	-	0.2	-	-	0.1	-	0.0
ADA1D	α_1D		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA1D	α_1D		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	2	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	0	-	100	-	-	25	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA2A	α_2A		Adrenoceptors	A	-	Bouvier	GEMTA	3	12		noradrenaline	Phys	2	5	1	1	Gi/o	4	4'	1'	2'	3'	58	100	68	60	log(Emax/EC50)	5.3	9.1	6.2	5.5	Gz	58	-	-	93	91	-	-	100	91	96	50	49	49	68	57	60	log(Emax/EC50)	5.3	-	-	8.5	8.3	-	-	9.1	8.3	8.8	4.6	4.4	4.4	6.2	5.2	5.5
ADA2A	α_2A		Adrenoceptors	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	2	5	1	1	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.03	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.03	-	-	-	-	-	-	0.00	-	-	-	0.00	-
ADA2A	α_2A		Adrenoceptors	A	-	Lambert	RGB-GDP	0	6		noradrenaline	Phys	2	5	1	1	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Efficacy	0.00	0.10	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Efficacy	0.00	-	-	0.10	-	-	-	-	-	-	0.00	-	-	-	0.00	-
ADA2A	α_2A		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	2	5	1	1	Gi/o	1	nc	1'	2'	nc	0	100	0	0	Activation rate (s^-1)	0.0	10.8	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	10.8	-	0.0	-	-	0.0	-	0.0
ADA2A	α_2A		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	5	1	1	Gi/o	2	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA2A	α_2A		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	2	5	1	1	Gi/o	4	4'	1'	2'	3'	14	100	17	15	-	-	-	-	-	Gz	14	-	-	98	91	-	-	100	96	96	12	49	49	34	19	30	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA2B	α_2B		Adrenoceptors	A	-	Bouvier	GEMTA	3	12		noradrenaline	Phys	1	3	1	-	Gi/o	2	nc	1'	2'	nc	0	100	72	0	log(Emax/EC50)	0.0	8.2	5.9	0.0	Gz	0	-	-	92	87	-	-	100	93	99	0	0	0	72	0	0	log(Emax/EC50)	0.0	-	-	7.5	7.1	-	-	8.2	7.6	8.1	0.0	0.0	0.0	5.9	0.0	0.0
ADA2B	α_2B		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	1	3	1	-	Gi/o	1	nc	1'	2'	nc	0	100	1	0	Activation rate (s^-1)	0.0	1.7	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	1	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.7	-	0.0	-	-	0.0	-	0.0
ADA2B	α_2B		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	3	1	-	Gi/o	2	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA2B	α_2B		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	1	3	1	-	Gi/o	2	nc	1'	2'	nc	0	100	36	0	-	-	-	-	-	Gz	0	-	-	92	87	-	-	100	96	99	0	0	0	36	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA2C	α_2C		Adrenoceptors	A	-	Bouvier	GEMTA	3	12		noradrenaline	Phys	1	3	1	1	Gi/o	3	nc	1'	3'	2'	0	100	55	55	log(Emax/EC50)	0.0	9.5	5.2	5.3	Gz	0	-	-	90	88	-	-	100	93	98	0	0	0	55	0	55	log(Emax/EC50)	0.0	-	-	8.5	8.4	-	-	9.5	8.9	9.4	0.0	0.0	0.0	5.2	0.0	5.3
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