Receptor | Source | Ligand | No. supporting datasets | Selectivity | Family rank orders | % of 1' G protein family | Quantitative values | % of 1' G protein subtype | Quantitative values | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Uniprot
|
GtoPdb (IUPHAR) |
GPCRdb | Rec. family | Cl | Other protein |
Lab | Biosensor | Down- stream steps |
#Gprots tested |
Ref | Name | Phys. / Surr. |
Gs | Gi/o | Gq/11 | G12/13 | Primary family |
#Fam | Gs | Gi/o | Gq/11 | G12/13 | Gs | Gi/o | Gq/11 | G12/13 | Parameter | Gs | Gi/o | Gq/11 | G12/13 | Primary subtype |
GsL | GsS | Golf | Gi1 | Gi2 | Gi3 | Ggust | Gz | GoA | GoB | Gq | G11 | G14 | G15 | G12 | G13 | Parameter | GsL | GsS | Golf | Gi1 | Gi2 | Gi3 | Ggust | Gz | GoA | GoB | Gq | G11 | G14 | G15 | G12 | G13 | |
5HT1A | 5-HT1A | ![]() |
5-Hydroxytryptamine | A | - | Bouvier | GEMTA | 3 | 12 | 5-hydroxytryptamine | Phys | - | 3 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 81 | 0 | log(Emax/EC50) | 0.0 | 8.3 | 6.7 | 0.0 | GoB | 0 | - | - | 92 | 85 | - | - | 96 | 97 | 100 | 0 | 0 | 65 | 81 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 7.6 | 7.0 | - | - | 7.9 | 8.0 | 8.3 | 0.0 | 0.0 | 5.4 | 6.7 | 0.0 | 0.0 | ||
5HT1A | 5-HT1A | ![]() |
5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | - | 3 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 1 | 0 | Activation rate (s-1) | 0.0 | 7.4 | 0.1 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 1 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 7.4 | - | 0.0 | - | - | 0.1 | - | 0.0 | ||
5HT1A | 5-HT1A | ![]() |
5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 2 | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT1A | 5-HT1A | ![]() |
5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 41 | 0 | - | - | - | - | - | GoB | 0 | - | - | 92 | 85 | - | - | 96 | 98 | 100 | 0 | 0 | 65 | 41 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT1B | 5-HT1B | ![]() |
5-Hydroxytryptamine | A | - | Bouvier | GEMTA | 3 | 12 | 5-hydroxytryptamine | Phys | - | 3 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 71 | 0 | log(Emax/EC50) | 0.0 | 8.7 | 6.2 | 0.0 | GoB | 0 | - | - | 99 | 98 | - | - | 93 | 98 | 100 | 0 | 0 | 0 | 71 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.6 | 8.6 | - | - | 8.1 | 8.5 | 8.7 | 0.0 | 0.0 | 0.0 | 6.2 | 0.0 | 0.0 | ||
5HT1B | 5-HT1B | ![]() |
5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | - | 3 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.4 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.4 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
5HT1B | 5-HT1B | ![]() |
5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 1 | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT1B | 5-HT1B | ![]() |
5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 36 | 0 | - | - | - | - | - | GoB | 0 | - | - | 99 | 98 | - | - | 93 | 99 | 100 | 0 | 0 | 0 | 36 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT1D | 5-HT1D | ![]() |
5-Hydroxytryptamine | A | - | Bouvier | GEMTA | 3 | 12 | 5-hydroxytryptamine | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | 8.6 | 0.0 | 0.0 | Gi1 | 0 | - | - | 100 | 100 | - | - | 43 | 94 | 94 | 0 | 0 | 0 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.6 | 8.6 | - | - | 3.7 | 8.1 | 8.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
5HT1D | 5-HT1D | ![]() |
5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.2 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
5HT1D | 5-HT1D | ![]() |
5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT1D | 5-HT1D | ![]() |
5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 100 | - | - | 43 | 97 | 94 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT1E | 5-HT1E | ![]() |
5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 2 | 0 | Activation rate (s-1) | 0.0 | 0.9 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 2 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.9 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
5HT1E | 5-HT1E | ![]() |
5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT1E | 5-HT1E | ![]() |
5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 2 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 2 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT1F | 5-HT1F | ![]() |
5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.4 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.4 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
5HT1F | 5-HT1F | ![]() |
5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT1F | 5-HT1F | ![]() |
5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT2A | 5-HT2A | ![]() |
5-Hydroxytryptamine | A | - | Bouvier | GEMTA | 3 | 12 | 5-hydroxytryptamine | Phys | - | 3 | 5 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 77 | 100 | 0 | log(Emax/EC50) | 0.0 | 6.7 | 8.6 | 0.0 | G14 | 0 | - | - | 68 | 63 | - | - | 77 | 62 | 66 | 98 | 99 | 100 | 93 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 5.9 | 5.5 | - | - | 6.7 | 5.4 | 5.7 | 8.4 | 8.5 | 8.6 | 8.0 | 0.0 | 0.0 | ||
5HT2A | 5-HT2A | ![]() |
5-Hydroxytryptamine | A | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | 3 | 5 | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |
5HT2A | 5-HT2A | ![]() |
5-Hydroxytryptamine | A | - | Lambert | RGB-GDP | 0 | 6 | - | 5-hydroxytryptamine | Phys | - | 3 | 5 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | Efficacy | 0.00 | 0.00 | 0.01 | 0.00 | Gq | 0 | - | - | 0 | - | - | - | - | - | - | 100 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.01 | - | - | - | 0.00 | - | |
5HT2A | 5-HT2A | ![]() |
5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | - | 3 | 5 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 12 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.5 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 12 | - | 100 | - | - | 17 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.5 | - | - | 0.1 | - | 0.0 | ||
5HT2A | 5-HT2A | ![]() |
5-Hydroxytryptamine | A | - | Inoue | TGF𝛼 | 5 | 1 | 5-hydroxytryptamine | Phys | - | 3 | 5 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.2 | - | - | - | - | - | ||
5HT2A | 5-HT2A | ![]() |
5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 5 | - | Gq/11 | 2 | - | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT2A | 5-HT2A | ![]() |
5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 5 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 22 | 75 | 0 | - | - | - | - | - | G14 | 0 | - | - | 23 | 63 | - | - | 77 | 37 | 66 | 74 | 99 | 100 | 55 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT2B | 5-HT2B | ![]() |
5-Hydroxytryptamine | A | - | Bouvier | GEMTA | 3 | 12 | 5-hydroxytryptamine | Phys | - | 1 | 4 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 99 | 100 | 0 | log(Emax/EC50) | 0.0 | 7.7 | 7.8 | 0.0 | Gq | 0 | - | - | 0 | 0 | - | - | 99 | 0 | 85 | 100 | 100 | 97 | 90 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 0.0 | 0.0 | - | - | 7.7 | 0.0 | 6.6 | 7.8 | 7.8 | 7.5 | 7.0 | 0.0 | 0.0 | ||
5HT2B | 5-HT2B | ![]() |
5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | - | 1 | 4 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.0 | 0.1 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 0 | - | 100 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.0 | - | 0.1 | - | - | 0.0 | - | 0.0 | ||
5HT2B | 5-HT2B | ![]() |
5-Hydroxytryptamine | A | - | Inoue | TGF𝛼 | 5 | 1 | 5-hydroxytryptamine | Phys | - | 1 | 4 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.6 | - | - | - | - | - | ||
5HT2B | 5-HT2B | ![]() |
5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 4 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT2B | 5-HT2B | ![]() |
5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 4 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 50 | 100 | 0 | - | - | - | - | - | Gq | 0 | - | - | 0 | 0 | - | - | 99 | 0 | 85 | 100 | 100 | 97 | 45 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT2C | 5-HT2C | ![]() |
5-Hydroxytryptamine | A | - | Bouvier | GEMTA | 3 | 12 | 5-hydroxytryptamine | Phys | - | 3 | 4 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 97 | 84 | log(Emax/EC50) | 0.0 | 8.7 | 8.4 | 7.3 | Gz | 0 | - | - | 79 | 77 | - | - | 100 | 78 | 84 | 0 | 0 | 0 | 97 | 84 | 84 | log(Emax/EC50) | 0.0 | - | - | 6.9 | 6.7 | - | - | 8.7 | 6.8 | 7.3 | 0.0 | 0.0 | 0.0 | 8.4 | 7.3 | 7.3 | ||
5HT2C | 5-HT2C | ![]() |
5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | - | 3 | 4 | 1 | Gq/11 | 2 | nc | 2' | 1' | 3' | 0 | 1 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 10.3 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 1 | - | 100 | - | - | 1 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 10.3 | - | - | 0.1 | - | 0.0 | ||
5HT2C | 5-HT2C | ![]() |
5-Hydroxytryptamine | A | - | Inoue | TGF𝛼 | 5 | 1 | 5-hydroxytryptamine | Phys | - | 3 | 4 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.4 | - | - | - | - | - | ||
5HT2C | 5-HT2C | ![]() |
5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 4 | 1 | Gq/11 | 2 | - | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT2C | 5-HT2C | ![]() |
5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 4 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 50 | 98 | 42 | - | - | - | - | - | Gz | 0 | - | - | 79 | 77 | - | - | 100 | 40 | 84 | 50 | 0 | 0 | 49 | 84 | 42 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT4R | 5-HT4 | ![]() |
5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | 2 | 1 | 1 | 2 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 4 | 9 | 2 | Activation rate (s-1) | 4.2 | 0.2 | 0.4 | 0.1 | GsL | 100 | - | - | - | - | - | - | - | 4 | - | 0 | - | - | 9 | - | 2 | Activation rate (s-1) | 4.2 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.4 | - | 0.1 | ||
5HT4R | 5-HT4 | ![]() |
5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 1 | 1 | 2 | Gs | 2 | 1' | - | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT4R | 5-HT4 | ![]() |
5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | 1 | 1 | 2 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 4 | 9 | 2 | - | - | - | - | - | GsL | 100 | - | - | - | - | - | - | - | 4 | - | 0 | - | - | 9 | - | 2 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT5A | 5-HT5A | ![]() |
5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
5HT5A | 5-HT5A | ![]() |
5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT5A | 5-HT5A | ![]() |
5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT6R | 5-HT6 | ![]() |
5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | 2 | - | 2 | 1 | Gs | 3 | 1' | nc | 2' | 3' | 100 | 0 | 26 | 11 | Activation rate (s-1) | 0.9 | 0.0 | 0.2 | 0.1 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 26 | - | 11 | Activation rate (s-1) | 0.9 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.2 | - | 0.1 | ||
5HT6R | 5-HT6 | ![]() |
5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | 2 | 1 | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT6R | 5-HT6 | ![]() |
5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | - | 2 | 1 | Gs | 3 | 1' | nc | 2' | 3' | 100 | 0 | 26 | 11 | - | - | - | - | - | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 26 | - | 11 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT7R | 5-HT7 | ![]() |
5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | 3 | 1 | 1 | - | Gs | 2 | 1' | 2' | nc | nc | 100 | 22 | 0 | 0 | Activation rate (s-1) | 0.9 | 0.2 | 0.0 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 22 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.9 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
5HT7R | 5-HT7 | ![]() |
5-Hydroxytryptamine | A | - | Roth | TRUPATH | 1 | 15 | 5-hydroxytryptamine | Phys | 3 | 1 | 1 | - | Gs | 1 | 1' | nc | nc | nc | 100 | 0 | 0 | 0 | log(Emax/EC50) | 100.0 | 0.0 | 0.0 | 0.0 | GsS | 99 | 100 | 99 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - | 0 | 0 | 0 | log(Emax/EC50) | 7.8 | 7.9 | 7.8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | - | 0.0 | 0.0 | 0.0 | ||
5HT7R | 5-HT7 | ![]() |
5-Hydroxytryptamine | A | - | Inoue | TGF𝛼 | 5 | 1 | 5-hydroxytryptamine | Phys | 3 | 1 | 1 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.8 | - | - | - | - | - | ||
5HT7R | 5-HT7 | ![]() |
5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 1 | 1 | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
5HT7R | 5-HT7 | ![]() |
5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | 3 | 1 | 1 | - | Gs | 2 | 1' | 2' | nc | nc | 100 | 11 | 0 | 0 | - | - | - | - | - | GsL | 100 | 100 | 99 | 0 | 0 | 0 | 0 | 0 | 11 | 0 | 0 | 0 | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ACM1 | M1 | ![]() |
Acetylcholine (muscarinic) | A | - | Bouvier | GEMTA | 3 | 12 | acetylcholine | Phys | 1 | 2 | 4 | - | Gq/11 | 3 | 2' | 3' | 1' | nc | 75 | 68 | 100 | 0 | log(Emax/EC50) | 5.8 | 5.3 | 7.8 | 0.0 | G11 | 75 | - | - | 64 | 59 | - | - | 68 | 57 | 61 | 97 | 100 | 98 | 99 | 0 | 0 | log(Emax/EC50) | 5.8 | - | - | 4.9 | 4.6 | - | - | 5.3 | 4.4 | 4.8 | 7.5 | 7.8 | 7.6 | 7.6 | 0.0 | 0.0 | ||
ACM1 | M1 | ![]() |
Acetylcholine (muscarinic) | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | acetylcholine | Phys | 1 | 2 | 4 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 5 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 2.4 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 5 | - | 100 | - | - | 55 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 2.4 | - | - | 1.3 | - | 0.0 | ||
ACM1 | M1 | ![]() |
Acetylcholine (muscarinic) | A | - | Inoue | TGF𝛼 | 5 | 1 | acetylcholine | Phys | 1 | 2 | 4 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.5 | - | - | - | - | - | ||
ACM1 | M1 | ![]() |
Acetylcholine (muscarinic) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 2 | 4 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ACM1 | M1 | ![]() |
Acetylcholine (muscarinic) | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 2 | 4 | - | Gq/11 | 3 | 2' | 3' | 1' | nc | 38 | 36 | 100 | 0 | - | - | - | - | - | G11 | 38 | - | - | 64 | 59 | - | - | 68 | 31 | 61 | 98 | 100 | 98 | 77 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ACM2 | M2 | ![]() |
Acetylcholine (muscarinic) | A | - | Bouvier | GEMTA | 3 | 12 | acetylcholine | Phys | 2 | 3 | 2 | - | Gi/o | 3 | 3' | 1' | 2' | nc | 65 | 100 | 86 | 0 | log(Emax/EC50) | 5.6 | 8.6 | 7.4 | 0.0 | GoB | 65 | - | - | 92 | 88 | - | - | 92 | 94 | 100 | 0 | 0 | 52 | 86 | 0 | 0 | log(Emax/EC50) | 5.6 | - | - | 7.9 | 7.6 | - | - | 8.0 | 8.1 | 8.6 | 0.0 | 0.0 | 4.5 | 7.4 | 0.0 | 0.0 | ||
ACM2 | M2 | ![]() |
Acetylcholine (muscarinic) | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | acetylcholine | Phys | 2 | 3 | 2 | - | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 2 | 0 | Activation rate (s-1) | 0.0 | 1.3 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 2 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 1.3 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
ACM2 | M2 | ![]() |
Acetylcholine (muscarinic) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 2 | 3 | 2 | - | Gi/o | 3 | 2' | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ACM2 | M2 | ![]() |
Acetylcholine (muscarinic) | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | 3 | 2 | - | Gi/o | 3 | 3' | 1' | 2' | nc | 32 | 100 | 44 | 0 | - | - | - | - | - | GoB | 32 | - | - | 92 | 88 | - | - | 92 | 97 | 100 | 0 | 0 | 52 | 44 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
DRD2 | D2 | ![]() |
Dopamine | A | - | Bouvier | GEMTA | 3 | 12 | dopamine | Phys | 1 | 5 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 61 | 0 | log(Emax/EC50) | 0.0 | 8.6 | 5.3 | 0.0 | GoB | 0 | - | - | 93 | 87 | - | - | 86 | 93 | 100 | 0 | 0 | 0 | 61 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.0 | 7.5 | - | - | 7.4 | 8.0 | 8.6 | 0.0 | 0.0 | 0.0 | 5.3 | 0.0 | 0.0 | ||
DRD2 | D2 | ![]() |
Dopamine | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 1 | 5 | 2 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.03 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.03 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
DRD2 | D2 | ![]() |
Dopamine | A | - | Lambert | RGB-GDP | 0 | 6 | dopamine | Phys | 1 | 5 | 2 | - | Gi/o | 3 | 3' | 1' | 2' | nc | 7 | 100 | 8 | 0 | Efficacy | 0.01 | 0.14 | 0.01 | 0.00 | Gi1 | 7 | - | - | 100 | - | - | - | - | - | - | 8 | - | - | - | 0 | - | Efficacy | 0.01 | - | - | 0.14 | - | - | - | - | - | - | 0.01 | - | - | - | 0.00 | - | ||
DRD2 | D2 | ![]() |
Dopamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | dopamine | Phys | 1 | 5 | 2 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 4.2 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 4.2 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
DRD2 | D2 | ![]() |
Dopamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 5 | 2 | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
DRD2 | D2 | ![]() |
Dopamine | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 5 | 2 | - | Gi/o | 3 | 3' | 1' | 2' | nc | 2 | 100 | 17 | 0 | - | - | - | - | - | GoB | 2 | - | - | 98 | 87 | - | - | 86 | 96 | 100 | 2 | 0 | 0 | 30 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ACM3 | M3 | ![]() |
Acetylcholine (muscarinic) | A | - | Bouvier | GEMTA | 3 | 12 | acetylcholine | Phys | 1 | 3 | 6 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 72 | 100 | 0 | log(Emax/EC50) | 0.0 | 5.4 | 7.6 | 0.0 | G15 | 0 | - | - | 72 | 65 | - | - | 67 | 67 | 69 | 94 | 97 | 97 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 5.4 | 4.9 | - | - | 5.1 | 5.0 | 5.2 | 7.1 | 7.4 | 7.3 | 7.6 | 0.0 | 0.0 | ||
ACM3 | M3 | ![]() |
Acetylcholine (muscarinic) | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 1 | 3 | 6 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | Econstitutive | 0.00 | 0.00 | 0.02 | 0.00 | Gq | 0 | - | - | 0 | - | - | - | - | - | - | 100 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.02 | - | - | - | 0.00 | - | ||
ACM3 | M3 | ![]() |
Acetylcholine (muscarinic) | A | - | Lambert | RGB-GDP | 0 | 6 | acetylcholine | Phys | 1 | 3 | 6 | - | Gq/11 | 3 | 3' | 2' | 1' | nc | 15 | 67 | 100 | 0 | Efficacy | 0.02 | 0.09 | 0.13 | 0.00 | Gq | 15 | - | - | 67 | - | - | - | - | - | - | 100 | - | - | - | 0 | - | Efficacy | 0.02 | - | - | 0.09 | - | - | - | - | - | - | 0.13 | - | - | - | 0.00 | - | ||
ACM3 | M3 | ![]() |
Acetylcholine (muscarinic) | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | acetylcholine | Phys | 1 | 3 | 6 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 13 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.6 | 5.0 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 13 | - | 100 | - | - | 49 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.6 | - | 5.0 | - | - | 2.5 | - | 0.0 | ||
ACM3 | M3 | ![]() |
Acetylcholine (muscarinic) | A | - | Inoue | TGF𝛼 | 5 | 1 | acetylcholine | Phys | 1 | 3 | 6 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.1 | - | - | - | - | - | ||
ACM3 | M3 | ![]() |
Acetylcholine (muscarinic) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 3 | 6 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ACM3 | M3 | ![]() |
Acetylcholine (muscarinic) | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 3 | 6 | - | Gq/11 | 3 | 3' | 2' | 1' | nc | 4 | 38 | 100 | 0 | - | - | - | - | - | Gq | 4 | - | - | 46 | 65 | - | - | 67 | 40 | 69 | 98 | 97 | 97 | 74 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ACM4 | M4 | ![]() |
Acetylcholine (muscarinic) | A | - | Bouvier | GEMTA | 3 | 12 | acetylcholine | Phys | 1 | 5 | 3 | 1 | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 78 | 0 | log(Emax/EC50) | 0.0 | 8.7 | 6.9 | 0.0 | GoB | 0 | - | - | 93 | 94 | - | - | 90 | 92 | 100 | 52 | 0 | 56 | 78 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.1 | 8.2 | - | - | 7.9 | 8.0 | 8.7 | 4.6 | 0.0 | 4.9 | 6.9 | 0.0 | 0.0 | ||
ACM4 | M4 | ![]() |
Acetylcholine (muscarinic) | A | - | Lambert | RGB-GDP | 0 | 6 | acetylcholine | Phys | 1 | 5 | 3 | 1 | Gi/o | 4 | 2' | 1' | 4' | 3' | 16 | 100 | 9 | 11 | Efficacy | 0.06 | 0.39 | 0.04 | 0.04 | Gi1 | 16 | - | - | 100 | - | - | - | - | - | - | 9 | - | - | - | 11 | - | Efficacy | 0.06 | - | - | 0.39 | - | - | - | - | - | - | 0.04 | - | - | - | 0.04 | - | ||
ACM4 | M4 | ![]() |
Acetylcholine (muscarinic) | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 1 | 5 | 3 | 1 | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.14 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.14 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
ACM4 | M4 | ![]() |
Acetylcholine (muscarinic) | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | acetylcholine | Phys | 1 | 5 | 3 | 1 | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 3 | 0 | Activation rate (s-1) | 0.0 | 5.8 | 0.2 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 3 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 5.8 | - | 0.0 | - | - | 0.2 | - | 0.0 | ||
ACM4 | M4 | ![]() |
Acetylcholine (muscarinic) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 5 | 3 | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ACM4 | M4 | ![]() |
Acetylcholine (muscarinic) | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 5 | 3 | 1 | Gi/o | 4 | 3' | 1' | 2' | 4' | 4 | 100 | 22 | 3 | - | - | - | - | - | GoB | 4 | - | - | 98 | 94 | - | - | 90 | 96 | 100 | 15 | 0 | 56 | 40 | 4 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ACM5 | M5 | ![]() |
Acetylcholine (muscarinic) | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | acetylcholine | Phys | - | 1 | 3 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 6 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.2 | 2.8 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 6 | - | 100 | - | - | 53 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.2 | - | 2.8 | - | - | 1.5 | - | 0.0 | ||
ACM5 | M5 | ![]() |
Acetylcholine (muscarinic) | A | - | Inoue | TGF𝛼 | 5 | 1 | acetylcholine | Phys | - | 1 | 3 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.1 | - | - | - | - | - | ||
ACM5 | M5 | ![]() |
Acetylcholine (muscarinic) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 3 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ACM5 | M5 | ![]() |
Acetylcholine (muscarinic) | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 3 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 6 | 100 | 0 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 6 | - | 100 | - | - | 53 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ADA1A | α1A | ![]() |
Adrenoceptors | A | - | Bouvier | GEMTA | 3 | 12 | noradrenaline | Phys | 2 | 1 | 4 | 1 | Gq/11 | 3 | 2' | 3' | 1' | nc | 85 | 78 | 100 | 0 | log(Emax/EC50) | 6.6 | 6.1 | 7.8 | 0.0 | G15 | 85 | - | - | 76 | 0 | - | - | 0 | 78 | 0 | 97 | 97 | 85 | 100 | 0 | 0 | log(Emax/EC50) | 6.6 | - | - | 5.9 | 0.0 | - | - | 0.0 | 6.1 | 0.0 | 7.6 | 7.5 | 6.6 | 7.8 | 0.0 | 0.0 | ||
ADA1A | α1A | ![]() |
Adrenoceptors | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | (±)-adrenaline | Phys | 2 | 1 | 4 | 1 | Gq/11 | 2 | 2' | nc | 1' | nc | 21 | 0 | 100 | 0 | Activation rate (s-1) | 0.3 | 0.0 | 1.3 | 0.0 | Gq | 21 | - | - | - | - | - | - | - | 0 | - | 100 | - | - | 29 | - | 0 | Activation rate (s-1) | 0.3 | - | - | - | - | - | - | - | 0.0 | - | 1.3 | - | - | 0.4 | - | 0.0 | ||
ADA1A | α1A | ![]() |
Adrenoceptors | A | - | Inoue | TGF𝛼 | 5 | 1 | (-)-noradrenaline | Phys | 2 | 1 | 4 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.0 | - | - | - | - | - | ||
ADA1A | α1A | ![]() |
Adrenoceptors | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 1 | 4 | 1 | Gq/11 | 2 | - | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ADA1A | α1A | ![]() |
Adrenoceptors | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | 1 | 4 | 1 | Gq/11 | 3 | 2' | 3' | 1' | nc | 53 | 39 | 100 | 0 | - | - | - | - | - | Gq | 53 | - | - | 76 | 0 | - | - | 0 | 39 | 0 | 98 | 97 | 85 | 64 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ADA1B | α1B | ![]() |
Adrenoceptors | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | (±)-adrenaline | Phys | - | - | 3 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.0 | 0.5 | 0.0 | G15 | 0 | - | - | - | - | - | - | - | 0 | - | 88 | - | - | 100 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.0 | - | 0.4 | - | - | 0.5 | - | 0.0 | ||
ADA1B | α1B | ![]() |
Adrenoceptors | A | - | Inoue | TGF𝛼 | 5 | 1 | (-)-noradrenaline | Phys | - | - | 3 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.1 | - | - | - | - | - | ||
ADA1B | α1B | ![]() |
Adrenoceptors | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 3 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ADA1B | α1B | ![]() |
Adrenoceptors | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 3 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | - | - | - | - | - | G15 | 0 | - | - | - | - | - | - | - | 0 | - | 88 | - | - | 100 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ADA1D | α1D | ![]() |
Adrenoceptors | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | (±)-adrenaline | Phys | - | - | 2 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.0 | 0.2 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 0 | - | 100 | - | - | 25 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.0 | - | 0.2 | - | - | 0.1 | - | 0.0 | ||
ADA1D | α1D | ![]() |
Adrenoceptors | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ADA1D | α1D | ![]() |
Adrenoceptors | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 0 | - | 100 | - | - | 25 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ADA2A | α2A | ![]() |
Adrenoceptors | A | - | Bouvier | GEMTA | 3 | 12 | noradrenaline | Phys | 2 | 5 | 1 | 1 | Gi/o | 4 | 4' | 1' | 2' | 3' | 58 | 100 | 68 | 60 | log(Emax/EC50) | 5.3 | 9.1 | 6.2 | 5.5 | Gz | 58 | - | - | 93 | 91 | - | - | 100 | 91 | 96 | 50 | 49 | 49 | 68 | 57 | 60 | log(Emax/EC50) | 5.3 | - | - | 8.5 | 8.3 | - | - | 9.1 | 8.3 | 8.8 | 4.6 | 4.4 | 4.4 | 6.2 | 5.2 | 5.5 | ||
ADA2A | α2A | ![]() |
Adrenoceptors | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 2 | 5 | 1 | 1 | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.03 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.03 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
ADA2A | α2A | ![]() |
Adrenoceptors | A | - | Lambert | RGB-GDP | 0 | 6 | noradrenaline | Phys | 2 | 5 | 1 | 1 | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Efficacy | 0.00 | 0.10 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.10 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
ADA2A | α2A | ![]() |
Adrenoceptors | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | (±)-adrenaline | Phys | 2 | 5 | 1 | 1 | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 10.8 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 10.8 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
ADA2A | α2A | ![]() |
Adrenoceptors | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 5 | 1 | 1 | Gi/o | 2 | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ADA2A | α2A | ![]() |
Adrenoceptors | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | 5 | 1 | 1 | Gi/o | 4 | 4' | 1' | 2' | 3' | 14 | 100 | 17 | 15 | - | - | - | - | - | Gz | 14 | - | - | 98 | 91 | - | - | 100 | 96 | 96 | 12 | 49 | 49 | 34 | 19 | 30 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ADA2B | α2B | ![]() |
Adrenoceptors | A | - | Bouvier | GEMTA | 3 | 12 | noradrenaline | Phys | 1 | 3 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 72 | 0 | log(Emax/EC50) | 0.0 | 8.2 | 5.9 | 0.0 | Gz | 0 | - | - | 92 | 87 | - | - | 100 | 93 | 99 | 0 | 0 | 0 | 72 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 7.5 | 7.1 | - | - | 8.2 | 7.6 | 8.1 | 0.0 | 0.0 | 0.0 | 5.9 | 0.0 | 0.0 | ||
ADA2B | α2B | ![]() |
Adrenoceptors | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | (±)-adrenaline | Phys | 1 | 3 | 1 | - | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 1 | 0 | Activation rate (s-1) | 0.0 | 1.7 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 1 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 1.7 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
ADA2B | α2B | ![]() |
Adrenoceptors | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 3 | 1 | - | Gi/o | 2 | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ADA2B | α2B | ![]() |
Adrenoceptors | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 3 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 36 | 0 | - | - | - | - | - | Gz | 0 | - | - | 92 | 87 | - | - | 100 | 96 | 99 | 0 | 0 | 0 | 36 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ADA2C | α2C | ![]() |
Adrenoceptors | A | - | Bouvier | GEMTA | 3 | 12 | noradrenaline | Phys | 1 | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 55 | 55 | log(Emax/EC50) | 0.0 | 9.5 | 5.2 | 5.3 | Gz | 0 | - | - | 90 | 88 | - | - | 100 | 93 | 98 | 0 | 0 | 0 | 55 | 0 | 55 | log(Emax/EC50) | 0.0 | - | - | 8.5 | 8.4 | - | - | 9.5 | 8.9 | 9.4 | 0.0 | 0.0 | 0.0 | 5.2 | 0.0 | 5.3 | ||
ADA2C | α2C | ![]() |
Adrenoceptors | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | (±)-adrenaline | Phys | 1 | 3 | 1 | 1 | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 9.1 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 9.1 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
ADA2C | α2C | ![]() |
Adrenoceptors | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 3 | 1 | 1 | Gi/o | 2 | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ADA2C | α2C | ![]() |
Adrenoceptors | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 28 | 28 | - | - | - | - | - | Gz | 0 | - | - | 90 | 88 | - | - | 100 | 96 | 98 | 0 | 0 | 0 | 28 | 0 | 28 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ADRB1 | β1 | ![]() |
Adrenoceptors | A | - | Bouvier | GEMTA | 3 | 12 | noradrenaline | Phys | 3 | 3 | 2 | 1 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 64 | 85 | 57 | log(Emax/EC50) | 9.6 | 6.1 | 8.2 | 5.5 | GsL | 100 | - | - | 0 | 0 | - | - | 64 | 56 | 60 | 48 | 0 | 56 | 85 | 57 | 54 | log(Emax/EC50) | 9.6 | - | - | 0.0 | 0.0 | - | - | 6.1 | 5.4 | 5.8 | 4.6 | 0.0 | 5.4 | 8.2 | 5.5 | 5.2 | ||
ADRB1 | β1 | ![]() |
Adrenoceptors | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | (±)-adrenaline | Phys | 3 | 3 | 2 | 1 | Gs | 3 | 1' | 3' | 2' | nc | 100 | 6 | 34 | 0 | Activation rate (s-1) | 2.9 | 0.2 | 1.0 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 6 | - | 0 | - | - | 34 | - | 0 | Activation rate (s-1) | 2.9 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 1.0 | - | 0.0 | ||
ADRB1 | β1 | ![]() |
Adrenoceptors | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 3 | 2 | 1 | Gs | 2 | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ADRB1 | β1 | ![]() |
Adrenoceptors | A | - | GproteinDb | merged data | - | - | - | - | - | 3 | 3 | 2 | 1 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 35 | 60 | 28 | - | - | - | - | - | GsL | 100 | - | - | 0 | 0 | - | - | 64 | 31 | 60 | 24 | 0 | 56 | 60 | 57 | 27 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ADRB2 | β2 | ![]() |
Adrenoceptors | A | - | Bouvier | GEMTA | 3 | 12 | noradrenaline | Phys | 6 | 3 | 4 | - | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 77 | 0 | log(Emax/EC50) | 8.2 | 0.0 | 6.3 | 0.0 | GsL | 100 | - | - | 0 | 0 | - | - | 0 | 0 | 0 | 0 | 0 | 0 | 77 | 0 | 0 | log(Emax/EC50) | 8.2 | - | - | 0.0 | 0.0 | - | - | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 6.3 | 0.0 | 0.0 | ||
ADRB2 | β2 | ![]() |
Adrenoceptors | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 6 | 3 | 4 | - | Gs | 1 | 1' | nc | nc | nc | 100 | 0 | 0 | 0 | Econstitutive | 0.02 | 0.00 | 0.00 | 0.00 | GsL | 100 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.02 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
ADRB2 | β2 | ![]() |
Adrenoceptors | A | - | Lambert | RGB-GDP | 0 | 6 | noradrenaline | Phys | 6 | 3 | 4 | - | Gs | 3 | 1' | 2' | 3' | nc | 100 | 56 | 25 | 0 | Efficacy | 0.09 | 0.05 | 0.02 | 0.00 | GsL | 100 | - | - | 56 | - | - | - | - | - | - | 25 | - | - | - | 0 | - | Efficacy | 0.09 | - | - | 0.05 | - | - | - | - | - | - | 0.02 | - | - | - | 0.00 | - | ||
ADRB2 | β2 | ![]() |
Adrenoceptors | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | (±)-adrenaline | Phys | 6 | 3 | 4 | - | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 11 | 0 | Activation rate (s-1) | 2.1 | 0.0 | 0.2 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 11 | - | 0 | Activation rate (s-1) | 2.1 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.2 | - | 0.0 | ||
ADRB2 | β2 | ![]() |
Adrenoceptors | A | - | Roth | TRUPATH | 1 | 15 | (-)-adrenaline | Phys | 6 | 3 | 4 | - | Gs | 3 | 1' | 3' | 2' | nc | 100 | 8 | 11 | 0 | log(Emax/EC50) | 79.8 | 6.6 | 8.5 | 0.0 | G15 | 80 | 76 | 80 | 0 | 78 | 0 | 0 | 64 | 64 | 70 | 0 | 0 | - | 100 | 0 | 0 | log(Emax/EC50) | 6.8 | 6.4 | 6.8 | 0.0 | 6.6 | 0.0 | 0.0 | 5.4 | 5.4 | 6.0 | 0.0 | 0.0 | - | 8.5 | 0.0 | 0.0 | ||
ADRB2 | β2 | ![]() |
Adrenoceptors | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 6 | 3 | 4 | - | Gs | 2 | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ADRB2 | β2 | ![]() |
Adrenoceptors | A | - | GproteinDb | merged data | - | - | - | - | - | 6 | 3 | 4 | - | Gs | 3 | 1' | 3' | 2' | nc | 100 | 13 | 25 | 0 | - | - | - | - | - | GsL | 96 | 76 | 80 | 14 | 39 | 0 | 0 | 32 | 21 | 35 | 5 | 0 | 0 | 63 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ADRB3 | β3 | ![]() |
Adrenoceptors | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | (±)-adrenaline | Phys | 2 | 1 | 1 | - | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 18 | 0 | Activation rate (s-1) | 0.5 | 0.0 | 0.1 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 18 | - | 0 | Activation rate (s-1) | 0.5 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.1 | - | 0.0 | ||
ADRB3 | β3 | ![]() |
Adrenoceptors | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 1 | 1 | - | Gs | 2 | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ADRB3 | β3 | ![]() |
Adrenoceptors | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | 1 | 1 | - | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 18 | 0 | - | - | - | - | - | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 18 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
DRD1 | D1 | ![]() |
Dopamine | A | - | Bouvier | GEMTA | 3 | 12 | dopamine | Phys | 5 | 2 | 2 | - | Gs | 3 | 1' | 3' | 2' | nc | 100 | 61 | 86 | 0 | log(Emax/EC50) | 8.6 | 5.3 | 7.4 | 0.0 | GsL | 100 | - | - | 0 | 0 | - | - | 61 | 0 | 56 | 0 | 0 | 0 | 86 | 0 | 0 | log(Emax/EC50) | 8.6 | - | - | 0.0 | 0.0 | - | - | 5.3 | 0.0 | 4.8 | 0.0 | 0.0 | 0.0 | 7.4 | 0.0 | 0.0 | ||
DRD1 | D1 | ![]() |
Dopamine | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 5 | 2 | 2 | - | Gs | 1 | 1' | nc | nc | nc | 100 | 0 | 0 | 0 | Econstitutive | 0.03 | 0.00 | 0.00 | 0.00 | GsL | 100 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.03 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
DRD1 | D1 | ![]() |
Dopamine | A | - | Lambert | RGB-GDP | 0 | 6 | dopamine | Phys | 5 | 2 | 2 | - | Gs | 2 | 1' | 2' | nc | nc | 100 | 71 | 0 | 0 | Efficacy | 0.05 | 0.04 | 0.00 | 0.00 | GsL | 100 | - | - | 71 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Efficacy | 0.05 | - | - | 0.04 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
DRD1 | D1 | ![]() |
Dopamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | dopamine | Phys | 5 | 2 | 2 | - | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 18 | 0 | Activation rate (s-1) | 1.1 | 0.0 | 0.2 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 18 | - | 0 | Activation rate (s-1) | 1.1 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.2 | - | 0.0 | ||
DRD1 | D1 | ![]() |
Dopamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 5 | 2 | 2 | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
DRD1 | D1 | ![]() |
Dopamine | A | - | GproteinDb | merged data | - | - | - | - | - | 5 | 2 | 2 | - | Gs | 3 | 1' | 2' | 3' | nc | 100 | 33 | 26 | 0 | - | - | - | - | - | GsL | 100 | - | - | 24 | 0 | - | - | 61 | 0 | 56 | 0 | 0 | 0 | 52 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
DRD3 | D3 | ![]() |
Dopamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | dopamine | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.3 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.3 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
DRD3 | D3 | ![]() |
Dopamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
DRD3 | D3 | ![]() |
Dopamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
DRD4 | D4 | ![]() |
Dopamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | dopamine | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 3.9 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 3.9 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
DRD4 | D4 | ![]() |
Dopamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
DRD4 | D4 | ![]() |
Dopamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
DRD5 | D5 | ![]() |
Dopamine | A | - | Bouvier | GEMTA | 3 | 12 | dopamine | Phys | 4 | 3 | 2 | - | Gs | 3 | 1' | 3' | 2' | nc | 100 | 70 | 91 | 0 | log(Emax/EC50) | 8.4 | 5.9 | 7.7 | 0.0 | GsL | 100 | - | - | 60 | 55 | - | - | 0 | 0 | 70 | 0 | 0 | 0 | 91 | 0 | 0 | log(Emax/EC50) | 8.4 | - | - | 5.1 | 4.6 | - | - | 0.0 | 0.0 | 5.9 | 0.0 | 0.0 | 0.0 | 7.7 | 0.0 | 0.0 | ||
DRD5 | D5 | ![]() |
Dopamine | A | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | 4 | 3 | 2 | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |
DRD5 | D5 | ![]() |
Dopamine | A | - | Lambert | RGB-GDP | 0 | 6 | - | dopamine | Phys | 4 | 3 | 2 | - | Gs | 2 | 1' | 2' | nc | nc | 100 | 65 | 0 | 0 | Efficacy | 0.02 | 0.02 | 0.00 | 0.00 | GsL | 100 | - | - | 65 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Efficacy | 0.02 | - | - | 0.02 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |
DRD5 | D5 | ![]() |
Dopamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | dopamine | Phys | 4 | 3 | 2 | - | Gs | 3 | 1' | 3' | 2' | nc | 100 | 14 | 41 | 0 | Activation rate (s-1) | 1.6 | 0.2 | 0.6 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 14 | - | 0 | - | - | 41 | - | 0 | Activation rate (s-1) | 1.6 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.6 | - | 0.0 | ||
DRD5 | D5 | ![]() |
Dopamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 4 | 3 | 2 | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
DRD5 | D5 | ![]() |
Dopamine | A | - | GproteinDb | merged data | - | - | - | - | - | 4 | 3 | 2 | - | Gs | 3 | 1' | 2' | 3' | nc | 75 | 37 | 33 | 0 | - | - | - | - | - | GsL | 75 | - | - | 42 | 55 | - | - | 0 | 7 | 70 | 0 | 0 | 0 | 66 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
HRH1 | H1 | ![]() |
Histamine | A | - | Bouvier | GEMTA | 3 | 12 | histamine | Phys | 2 | 3 | 6 | 2 | Gq/11 | 4 | 4' | 2' | 1' | 3' | 68 | 83 | 100 | 71 | log(Emax/EC50) | 5.5 | 6.8 | 8.1 | 5.8 | G15 | 68 | - | - | 79 | 75 | - | - | 83 | 73 | 75 | 92 | 95 | 95 | 100 | 71 | 67 | log(Emax/EC50) | 5.5 | - | - | 6.4 | 6.1 | - | - | 6.8 | 6.0 | 6.1 | 7.5 | 7.7 | 7.8 | 8.1 | 5.8 | 5.5 | ||
HRH1 | H1 | ![]() |
Histamine | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 2 | 3 | 6 | 2 | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | Econstitutive | 0.00 | 0.00 | 0.01 | 0.00 | Gq | 0 | - | - | 0 | - | - | - | - | - | - | 100 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.01 | - | - | - | 0.00 | - | ||
HRH1 | H1 | ![]() |
Histamine | A | - | Lambert | RGB-GDP | 0 | 6 | histamine | Phys | 2 | 3 | 6 | 2 | Gq/11 | 3 | 3' | 2' | 1' | nc | 28 | 96 | 100 | 0 | Efficacy | 0.02 | 0.07 | 0.08 | 0.00 | Gq | 28 | - | - | 96 | - | - | - | - | - | - | 100 | - | - | - | 0 | - | Efficacy | 0.02 | - | - | 0.07 | - | - | - | - | - | - | 0.08 | - | - | - | 0.00 | - | ||
HRH1 | H1 | ![]() |
Histamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | histamine | Phys | 2 | 3 | 6 | 2 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 30 | 100 | 12 | Activation rate (s-1) | 0.0 | 0.4 | 1.3 | 0.1 | Gq | 0 | - | - | - | - | - | - | - | 30 | - | 100 | - | - | 46 | - | 12 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.4 | - | 1.3 | - | - | 0.6 | - | 0.1 | ||
HRH1 | H1 | ![]() |
Histamine | A | - | Inoue | TGF𝛼 | 5 | 1 | histamine | Phys | 2 | 3 | 6 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.2 | - | - | - | - | - | ||
HRH1 | H1 | ![]() |
Histamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 3 | 6 | 2 | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
HRH1 | H1 | ![]() |
Histamine | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | 3 | 6 | 2 | Gq/11 | 4 | 3' | 2' | 1' | 4' | 24 | 52 | 100 | 21 | - | - | - | - | - | Gq | 24 | - | - | 58 | 75 | - | - | 83 | 52 | 75 | 98 | 95 | 95 | 73 | 24 | 40 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
HRH2 | H2 | ![]() |
Histamine | A | - | Bouvier | GEMTA | 3 | 12 | histamine | Phys | 5 | 2 | 4 | 1 | Gs | 4 | 1' | 4' | 2' | 3' | 100 | 58 | 93 | 63 | log(Emax/EC50) | 7.0 | 4.1 | 6.5 | 4.4 | GsL | 100 | - | - | 0 | 0 | - | - | 46 | 58 | 58 | 0 | 0 | 0 | 93 | 58 | 63 | log(Emax/EC50) | 7.0 | - | - | 0.0 | 0.0 | - | - | 3.2 | 4.0 | 4.1 | 0.0 | 0.0 | 0.0 | 6.5 | 4.0 | 4.4 | ||
HRH2 | H2 | ![]() |
Histamine | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 5 | 2 | 4 | 1 | Gs | 1 | 1' | nc | nc | nc | 100 | 0 | 0 | 0 | Econstitutive | 0.07 | 0.00 | 0.00 | 0.00 | GsL | 100 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.07 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
HRH2 | H2 | ![]() |
Histamine | A | - | Lambert | RGB-GDP | 0 | 6 | amthamine | Surr | 5 | 2 | 4 | 1 | Gs | 3 | 1' | 2' | 3' | nc | 100 | 24 | 20 | 0 | Efficacy | 0.08 | 0.02 | 0.02 | 0.00 | GsL | 100 | - | - | 24 | - | - | - | - | - | - | 20 | - | - | - | 0 | - | Efficacy | 0.08 | - | - | 0.02 | - | - | - | - | - | - | 0.02 | - | - | - | 0.00 | - | ||
HRH2 | H2 | ![]() |
Histamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | histamine | Phys | 5 | 2 | 4 | 1 | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 33 | 0 | Activation rate (s-1) | 1.6 | 0.0 | 0.5 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 33 | - | 0 | Activation rate (s-1) | 1.6 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.5 | - | 0.0 | ||
HRH2 | H2 | ![]() |
Histamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 5 | 2 | 4 | 1 | Gq/11 | 2 | 2' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
HRH2 | H2 | ![]() |
Histamine | A | - | GproteinDb | merged data | - | - | - | - | - | 5 | 2 | 4 | 1 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 20 | 36 | 16 | - | - | - | - | - | GsL | 100 | - | - | 8 | 0 | - | - | 46 | 29 | 58 | 5 | 0 | 0 | 63 | 19 | 32 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
HRH3 | H3 | ![]() |
Histamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | histamine | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 2.3 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 2.3 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
HRH3 | H3 | ![]() |
Histamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
HRH3 | H3 | ![]() |
Histamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
HRH4 | H4 | ![]() |
Histamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
HRH4 | H4 | ![]() |
Histamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
TAAR1 | TA1 | ![]() |
Trace amine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | 1 | - | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
TAAR1 | TA1 | ![]() |
Trace amine | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | 1 | - | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
AGTR1 | AT1 | ![]() |
Angiotensin | A | - | Bouvier | GEMTA | 3 | 12 | angiotensin II | Phys | - | 3 | 4 | 1 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 79 | 100 | 96 | log(Emax/EC50) | 0.0 | 7.1 | 9.0 | 8.6 | G11 | 0 | - | - | 77 | 76 | - | - | 71 | 79 | 77 | 97 | 100 | 91 | 92 | 93 | 96 | log(Emax/EC50) | 0.0 | - | - | 6.9 | 6.8 | - | - | 6.4 | 7.1 | 6.9 | 8.7 | 9.0 | 8.2 | 8.2 | 8.3 | 8.6 | ||
AGTR1 | AT1 | ![]() |
Angiotensin | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 3 | 4 | 1 | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
AGTR1 | AT1 | ![]() |
Angiotensin | A | - | Lambert | RGB-GDP | 0 | 6 | angiotensin II | Phys | - | 3 | 4 | 1 | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 58 | 100 | 0 | Efficacy | 0.00 | 0.03 | 0.05 | 0.00 | Gq | 0 | - | - | 58 | - | - | - | - | - | - | 100 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.03 | - | - | - | - | - | - | 0.05 | - | - | - | 0.00 | - | ||
AGTR1 | AT1 | ![]() |
Angiotensin | A | - | Inoue | TGF𝛼 | 5 | 1 | angiotensin II | Phys | - | 3 | 4 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 10.0 | - | - | - | - | - | ||
AGTR1 | AT1 | ![]() |
Angiotensin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 4 | 1 | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
AGTR1 | AT1 | ![]() |
Angiotensin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 4 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 46 | 67 | 32 | - | - | - | - | - | G11 | 0 | - | - | 45 | 76 | - | - | 71 | 79 | 77 | 66 | 100 | 91 | 92 | 31 | 96 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
AGTR2 | AT2 | ![]() |
Angiotensin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
AGTR2 | AT2 | ![]() |
Angiotensin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
APJ | Apelin | ![]() |
Apelin | A | - | Bouvier | GEMTA | 3 | 12 | [Pyr1]apelin-13 | Phys | - | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 63 | 72 | log(Emax/EC50) | 0.0 | 9.3 | 5.8 | 6.7 | Gi1 | 0 | - | - | 100 | 99 | - | - | 85 | 94 | 96 | 0 | 0 | 0 | 63 | 72 | 64 | log(Emax/EC50) | 0.0 | - | - | 9.3 | 9.2 | - | - | 7.9 | 8.7 | 8.9 | 0.0 | 0.0 | 0.0 | 5.8 | 6.7 | 5.9 | ||
APJ | Apelin | ![]() |
Apelin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | apelin-17 | Phys | - | 3 | 1 | 1 | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 5.8 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 5.8 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
APJ | Apelin | ![]() |
Apelin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 1 | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
APJ | Apelin | ![]() |
Apelin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 32 | 36 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 99 | - | - | 85 | 97 | 96 | 0 | 0 | 0 | 32 | 72 | 32 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NMBR | BB1 | ![]() |
Bombesin | A | - | Inoue | TGF𝛼 | 5 | 1 | neuromedin B | Phys | - | - | 2 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 10.4 | - | - | - | - | - | ||
NMBR | BB1 | ![]() |
Bombesin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NMBR | BB1 | ![]() |
Bombesin | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
GRPR | BB2 | ![]() |
Bombesin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | gastrin-releasing peptide | Phys | - | 1 | 3 | 1 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 2 | 100 | 6 | Activation rate (s-1) | 0.0 | 0.1 | 4.6 | 0.3 | Gq | 0 | - | - | - | - | - | - | - | 2 | - | 100 | - | - | 0 | - | 6 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 4.6 | - | - | 0.0 | - | 0.3 | ||
GRPR | BB2 | ![]() |
Bombesin | A | - | Inoue | TGF𝛼 | 5 | 1 | bombesin | Phys | - | 1 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.9 | - | - | - | - | - | ||
GRPR | BB2 | ![]() |
Bombesin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 3 | 1 | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
GRPR | BB2 | ![]() |
Bombesin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 3 | 1 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 2 | 100 | 6 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 2 | - | 100 | - | - | 0 | - | 6 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
BRS3 | BB3 | ![]() |
Bombesin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | [125I][D-Tyr6,β-Ala11,Phe13,Nle14]bombesin-(6-14) | Phys | - | - | 2 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.0 | 0.1 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 0 | - | 100 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.0 | - | 0.1 | - | - | 0.0 | - | 0.0 | ||
BRS3 | BB3 | ![]() |
Bombesin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
BRS3 | BB3 | ![]() |
Bombesin | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 0 | - | 100 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
BKRB1 | B1 | ![]() |
Bradykinin | A | - | Bouvier | GEMTA | 3 | 12 | kallidin | Phys | - | 2 | 3 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 94 | 100 | 0 | log(Emax/EC50) | 0.0 | 6.0 | 6.4 | 0.0 | G15 | 0 | - | - | 88 | 88 | - | - | 85 | 88 | 94 | 95 | 95 | 95 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 5.7 | 5.6 | - | - | 5.5 | 5.6 | 6.0 | 6.1 | 6.1 | 6.1 | 6.4 | 0.0 | 0.0 | ||
BKRB1 | B1 | ![]() |
Bradykinin | A | - | Inoue | TGF𝛼 | 5 | 1 | bradykinin | Phys | - | 2 | 3 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.5 | - | - | - | - | - | ||
BKRB1 | B1 | ![]() |
Bradykinin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 3 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
BKRB1 | B1 | ![]() |
Bradykinin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 3 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 94 | 100 | 0 | - | - | - | - | - | G15 | 0 | - | - | 88 | 88 | - | - | 85 | 88 | 94 | 95 | 95 | 95 | 100 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
BKRB2 | B2 | ![]() |
Bradykinin | A | - | Bouvier | GEMTA | 3 | 12 | kallidin | Phys | 1 | 3 | 4 | 2 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 85 | 100 | 98 | log(Emax/EC50) | 0.0 | 8.0 | 9.4 | 9.2 | Gq | 0 | - | - | 83 | 77 | - | - | 85 | 75 | 82 | 100 | 100 | 100 | 93 | 98 | 95 | log(Emax/EC50) | 0.0 | - | - | 7.9 | 7.3 | - | - | 8.0 | 7.0 | 7.7 | 9.4 | 9.4 | 9.4 | 8.7 | 9.2 | 9.0 | ||
BKRB2 | B2 | ![]() |
Bradykinin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | bradykinin | Phys | 1 | 3 | 4 | 2 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 3 | 100 | 8 | Activation rate (s-1) | 0.0 | 0.2 | 4.4 | 0.4 | Gq | 0 | - | - | - | - | - | - | - | 3 | - | 100 | - | - | 4 | - | 8 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.2 | - | 4.4 | - | - | 0.2 | - | 0.4 | ||
BKRB2 | B2 | ![]() |
Bradykinin | A | - | Inoue | TGF𝛼 | 5 | 1 | kallidin | Phys | 1 | 3 | 4 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.8 | - | - | - | - | - | ||
BKRB2 | B2 | ![]() |
Bradykinin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 3 | 4 | 2 | Gq/11 | 3 | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
BKRB2 | B2 | ![]() |
Bradykinin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 3 | 4 | 2 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 44 | 100 | 53 | - | - | - | - | - | Gq | 0 | - | - | 83 | 77 | - | - | 85 | 39 | 82 | 100 | 100 | 100 | 48 | 98 | 52 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCKAR | CCK1 | ![]() |
Cholecystokinin | A | - | Bouvier | GEMTA | 3 | 12 | CCK-8 | Phys | 3 | 2 | 4 | 2 | G12/13 | 4 | 4' | 3' | 2' | 1' | 83 | 88 | 99 | 100 | log(Emax/EC50) | 8.1 | 8.5 | 9.7 | 9.7 | G12 | 83 | - | - | 87 | 84 | - | - | 80 | 88 | 87 | 96 | 98 | 99 | 90 | 100 | 94 | log(Emax/EC50) | 8.1 | - | - | 8.4 | 8.2 | - | - | 7.8 | 8.5 | 8.5 | 9.4 | 9.6 | 9.7 | 8.8 | 9.7 | 9.2 | ||
CCKAR | CCK1 | ![]() |
Cholecystokinin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | CCK-8 | Phys | 3 | 2 | 4 | 2 | Gq/11 | 4 | 4' | 2' | 1' | 3' | 5 | 78 | 100 | 18 | Activation rate (s-1) | 0.2 | 3.2 | 4.1 | 0.7 | Gq | 5 | - | - | - | - | - | - | - | 78 | - | 100 | - | - | 14 | - | 18 | Activation rate (s-1) | 0.2 | - | - | - | - | - | - | - | 3.2 | - | 4.1 | - | - | 0.6 | - | 0.7 | ||
CCKAR | CCK1 | ![]() |
Cholecystokinin | A | - | Inoue | TGF𝛼 | 5 | 1 | CCK-8 | Phys | 3 | 2 | 4 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 10.5 | - | - | - | - | - | ||
CCKAR | CCK1 | ![]() |
Cholecystokinin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 2 | 4 | 2 | Gq/11 | 2 | 2' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCKAR | CCK1 | ![]() |
Cholecystokinin | A | - | GproteinDb | merged data | - | - | - | - | - | 3 | 2 | 4 | 2 | Gq/11 | 4 | 4' | 2' | 1' | 3' | 44 | 83 | 100 | 59 | - | - | - | - | - | G12 | 44 | - | - | 87 | 84 | - | - | 80 | 83 | 87 | 98 | 98 | 99 | 52 | 100 | 56 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
GASR | CCK2 | ![]() |
Cholecystokinin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | CCK-8 | Phys | - | 1 | 3 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 34 | 100 | 12 | Activation rate (s-1) | 0.0 | 1.4 | 4.1 | 0.5 | Gq | 0 | - | - | - | - | - | - | - | 34 | - | 100 | - | - | 29 | - | 12 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 1.4 | - | 4.1 | - | - | 1.2 | - | 0.5 | ||
GASR | CCK2 | ![]() |
Cholecystokinin | A | - | Inoue | TGF𝛼 | 5 | 1 | CCK-8 | Phys | - | 1 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 10.0 | - | - | - | - | - | ||
GASR | CCK2 | ![]() |
Cholecystokinin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 3 | 1 | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GASR | CCK2 | ![]() |
Cholecystokinin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 3 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 34 | 100 | 12 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 34 | - | 100 | - | - | 29 | - | 12 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
C5AR1 | C5a1 | ![]() |
Complement peptide | A | - | Bouvier | GEMTA | 3 | 12 | C5a | Phys | - | 4 | 2 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 99 | 100 | 0 | log(Emax/EC50) | 0.0 | 9.2 | 9.3 | 0.0 | G15 | 0 | - | - | 98 | 99 | - | - | 88 | 92 | 98 | 0 | 0 | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 9.1 | 9.2 | - | - | 8.1 | 8.5 | 9.1 | 0.0 | 0.0 | 0.0 | 9.3 | 0.0 | 0.0 | ||
C5AR1 | C5a1 | ![]() |
Complement peptide | A | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | 4 | 2 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.03 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.03 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |
C5AR1 | C5a1 | ![]() |
Complement peptide | A | - | Lambert | RGB-GDP | 0 | 6 | - | C5a | Phys | - | 4 | 2 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Efficacy | 0.00 | 0.05 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.05 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |
C5AR1 | C5a1 | ![]() |
Complement peptide | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 4 | 2 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
C5AR1 | C5a1 | ![]() |
Complement peptide | A | - | GproteinDb | merged data | - | - | - | - | - | - | 4 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 33 | 0 | - | - | - | - | - | G15 | 0 | - | - | 99 | 99 | - | - | 88 | 92 | 98 | 0 | 0 | 0 | 100 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
EDNRA | ETA | ![]() |
Endothelin | A | - | Bouvier | GEMTA | 3 | 12 | endothelin-1 | Phys | 1 | 3 | 5 | 3 | G12/13 | 4 | 4' | 2' | 3' | 1' | 78 | 96 | 93 | 100 | log(Emax/EC50) | 8.1 | 9.9 | 9.6 | 10.3 | G12 | 78 | - | - | 90 | 90 | - | - | 96 | 91 | 93 | 92 | 91 | 93 | 79 | 100 | 92 | log(Emax/EC50) | 8.1 | - | - | 9.3 | 9.3 | - | - | 9.9 | 9.4 | 9.6 | 9.5 | 9.5 | 9.6 | 8.2 | 10.3 | 9.6 | ||
EDNRA | ETA | ![]() |
Endothelin | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 1 | 3 | 5 | 3 | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
EDNRA | ETA | ![]() |
Endothelin | A | - | Lambert | RGB-GDP | 0 | 6 | endothelin-1 | Phys | 1 | 3 | 5 | 3 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 94 | 36 | Efficacy | 0.00 | 0.06 | 0.06 | 0.02 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 94 | - | - | - | 36 | - | Efficacy | 0.00 | - | - | 0.06 | - | - | - | - | - | - | 0.06 | - | - | - | 0.02 | - | ||
EDNRA | ETA | ![]() |
Endothelin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | endothelin-2 | Phys | 1 | 3 | 5 | 3 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 40 | 18 | Activation rate (s-1) | 0.0 | 0.5 | 0.2 | 0.1 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 40 | - | - | 0 | - | 18 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.5 | - | 0.2 | - | - | 0.0 | - | 0.1 | ||
EDNRA | ETA | ![]() |
Endothelin | A | - | Inoue | TGF𝛼 | 5 | 1 | endothelin-1 | Phys | 1 | 3 | 5 | 3 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 10.0 | - | - | - | - | - | ||
EDNRA | ETA | ![]() |
Endothelin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 3 | 5 | 3 | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
EDNRA | ETA | ![]() |
Endothelin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 3 | 5 | 3 | Gi/o | 4 | 4' | 1' | 2' | 3' | 20 | 74 | 57 | 38 | - | - | - | - | - | Gz | 20 | - | - | 63 | 90 | - | - | 96 | 96 | 93 | 56 | 91 | 93 | 40 | 45 | 55 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
EDNRB | ETB | ![]() |
Endothelin | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 1 | 3 | 4 | 2 | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
EDNRB | ETB | ![]() |
Endothelin | A | - | Lambert | RGB-GDP | 0 | 6 | endothelin-1 | Phys | 1 | 3 | 4 | 2 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 54 | 12 | Efficacy | 0.00 | 0.09 | 0.05 | 0.01 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 54 | - | - | - | 12 | - | Efficacy | 0.00 | - | - | 0.09 | - | - | - | - | - | - | 0.05 | - | - | - | 0.01 | - | ||
EDNRB | ETB | ![]() |
Endothelin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | endothelin-2 | Phys | 1 | 3 | 4 | 2 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 24 | 20 | Activation rate (s-1) | 0.0 | 10.2 | 2.4 | 2.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 24 | - | - | 0 | - | 20 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 10.2 | - | 2.4 | - | - | 0.0 | - | 2.0 | ||
EDNRB | ETB | ![]() |
Endothelin | A | - | Inoue | TGF𝛼 | 5 | 1 | endothelin-1 | Phys | 1 | 3 | 4 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.4 | - | - | - | - | - | ||
EDNRB | ETB | ![]() |
Endothelin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 3 | 4 | 2 | Gs | 3 | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
EDNRB | ETB | ![]() |
Endothelin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 3 | 4 | 2 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 67 | 26 | 11 | - | - | - | - | - | GoA | 0 | - | - | 50 | - | - | - | - | 100 | - | 26 | - | - | 0 | 6 | 20 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
FPR1 | FPR1 | ![]() |
Formylpeptide | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.07 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.07 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
FPR1 | FPR1 | ![]() |
Formylpeptide | A | - | Lambert | RGB-GDP | 0 | 6 | WKYMVM | Surr | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Efficacy | 0.00 | 0.12 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.12 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
FPR1 | FPR1 | ![]() |
Formylpeptide | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
FPR1 | FPR1 | ![]() |
Formylpeptide | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
FPR2 | FPR2/ALX | ![]() |
Formylpeptide | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 3 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.05 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.05 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
FPR2 | FPR2/ALX | ![]() |
Formylpeptide | A | - | Lambert | RGB-GDP | 0 | 6 | WKYMVM | Surr | - | 3 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Efficacy | 0.00 | 0.09 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.09 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
FPR2 | FPR2/ALX | ![]() |
Formylpeptide | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 1 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
FPR2 | FPR2/ALX | ![]() |
Formylpeptide | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
FPR3 | FPR3 | ![]() |
Formylpeptide | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
FPR3 | FPR3 | ![]() |
Formylpeptide | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
GALR1 | GAL1 | ![]() |
Galanin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | galanin | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 6.0 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 6.0 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
GALR1 | GAL1 | ![]() |
Galanin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GALR1 | GAL1 | ![]() |
Galanin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
GALR2 | GAL2 | ![]() |
Galanin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | galanin | Phys | - | 2 | 3 | 2 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 11 | 100 | 17 | Activation rate (s-1) | 0.0 | 0.1 | 1.1 | 0.2 | Gq | 0 | - | - | - | - | - | - | - | 11 | - | 100 | - | - | 7 | - | 17 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 1.1 | - | - | 0.1 | - | 0.2 | ||
GALR2 | GAL2 | ![]() |
Galanin | A | - | Inoue | TGF𝛼 | 5 | 1 | galanin | Phys | - | 2 | 3 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.1 | - | - | - | - | - | ||
GALR2 | GAL2 | ![]() |
Galanin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 3 | 2 | Gq/11 | 3 | - | 2' | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GALR2 | GAL2 | ![]() |
Galanin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 3 | 2 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 11 | 100 | 17 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 11 | - | 100 | - | - | 7 | - | 17 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
GALR3 | GAL3 | ![]() |
Galanin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | galanin | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
GALR3 | GAL3 | ![]() |
Galanin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GALR3 | GAL3 | ![]() |
Galanin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
GHSR | Ghrelin | ![]() |
Ghrelin | A | - | Bouvier | GEMTA | 3 | 12 | ghrelin | Phys | - | 2 | 3 | 2 | G12/13 | 3 | nc | 3' | 2' | 1' | 0 | 88 | 90 | 100 | log(Emax/EC50) | 0.0 | 8.2 | 8.3 | 9.3 | G12 | 0 | - | - | 85 | 82 | - | - | 88 | 85 | 88 | 90 | 88 | 89 | 89 | 100 | 90 | log(Emax/EC50) | 0.0 | - | - | 7.9 | 7.7 | - | - | 8.2 | 7.9 | 8.2 | 8.3 | 8.2 | 8.3 | 8.3 | 9.3 | 8.4 | ||
GHSR | Ghrelin | ![]() |
Ghrelin | A | - | Inoue | TGF𝛼 | 5 | 1 | ibutamoren | Surr | - | 2 | 3 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.2 | - | - | - | - | - | ||
GHSR | Ghrelin | ![]() |
Ghrelin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 3 | 2 | Gq/11 | 3 | - | 2' | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GHSR | Ghrelin | ![]() |
Ghrelin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 3 | 2 | G12/13 | 3 | nc | 3' | 2' | 1' | 0 | 88 | 90 | 100 | - | - | - | - | - | G12 | 0 | - | - | 85 | 82 | - | - | 88 | 85 | 88 | 90 | 88 | 89 | 89 | 100 | 90 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
GNRHR | GnRH1 | ![]() |
Gonadotrophin-releasing hormone | A | - | Bouvier | GEMTA | 3 | 12 | GnRH I | Phys | - | 1 | 3 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | log(Emax/EC50) | 0.0 | 0.0 | 8.9 | 0.0 | Gq | 0 | - | - | 0 | 0 | - | - | 0 | 0 | 0 | 100 | 100 | 92 | 94 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 0.0 | 0.0 | - | - | 0.0 | 0.0 | 0.0 | 8.9 | 8.9 | 8.2 | 8.3 | 0.0 | 0.0 | ||
GNRHR | GnRH1 | ![]() |
Gonadotrophin-releasing hormone | A | - | Inoue | TGF𝛼 | 5 | 1 | leuprolide | Surr | - | 1 | 3 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.1 | - | - | - | - | - | ||
GNRHR | GnRH1 | ![]() |
Gonadotrophin-releasing hormone | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 3 | - | Gq/11 | 2 | - | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
GNRHR | GnRH1 | ![]() |
Gonadotrophin-releasing hormone | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 3 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | - | - | - | - | - | Gq | 0 | - | - | 0 | 0 | - | - | 0 | 0 | 0 | 100 | 100 | 92 | 94 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
KISSR | Kisspeptin | ![]() |
Kisspeptin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | kisspeptin-10 | Phys | - | - | 3 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.0 | 1.8 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 0 | - | 100 | - | - | 29 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.0 | - | 1.8 | - | - | 0.5 | - | 0.0 | ||
KISSR | Kisspeptin | ![]() |
Kisspeptin | A | - | Inoue | TGF𝛼 | 5 | 1 | kisspeptin-10 | Phys | - | - | 3 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.9 | - | - | - | - | - | ||
KISSR | Kisspeptin | ![]() |
Kisspeptin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
KISSR | Kisspeptin | ![]() |
Kisspeptin | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 3 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 0 | - | 100 | - | - | 29 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
MCHR1 | MCH1 | ![]() |
Melanin-concentrating hormone | A | - | Inoue | TGF𝛼 | 5 | 1 | melanin-concentrating hormone | Phys | 1 | 1 | 2 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.2 | - | - | - | - | - | ||
MCHR1 | MCH1 | ![]() |
Melanin-concentrating hormone | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | 2 | - | Gi/o | 3 | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
MCHR1 | MCH1 | ![]() |
Melanin-concentrating hormone | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | 2 | - | Gi/o | 3 | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
MCHR2 | MCH2 | ![]() |
Melanin-concentrating hormone | A | - | Inoue | TGF𝛼 | 5 | 1 | melanin-concentrating hormone | Phys | - | - | 2 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.4 | - | - | - | - | - | ||
MCHR2 | MCH2 | ![]() |
Melanin-concentrating hormone | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MCHR2 | MCH2 | ![]() |
Melanin-concentrating hormone | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
MSHR | MC1 | ![]() |
Melanocortin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | α-MSH | Phys | 2 | - | - | - | Gs | 1 | 1' | nc | 2' | nc | 100 | 0 | 5 | 0 | Activation rate (s-1) | 0.5 | 0.0 | 0.0 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 5 | - | 0 | Activation rate (s-1) | 0.5 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
MSHR | MC1 | ![]() |
Melanocortin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | - | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
MSHR | MC1 | ![]() |
Melanocortin | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | - | - | - | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 5 | 0 | - | - | - | - | - | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 5 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ACTHR | MC2 | ![]() |
Melanocortin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
ACTHR | MC2 | ![]() |
Melanocortin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | - | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
MC3R | MC3 | ![]() |
Melanocortin | A | - | Bouvier | GEMTA | 3 | 12 | γ-MSH | Phys | 3 | 1 | 3 | 1 | Gq/11 | 4 | 2' | 3' | 1' | 4' | 92 | 75 | 100 | 61 | log(Emax/EC50) | 9.5 | 7.8 | 10.3 | 6.3 | G15 | 92 | - | - | 0 | 0 | - | - | 75 | 0 | 67 | 0 | 0 | 0 | 100 | 61 | 60 | log(Emax/EC50) | 9.5 | - | - | 0.0 | 0.0 | - | - | 7.8 | 0.0 | 6.9 | 0.0 | 0.0 | 0.0 | 10.3 | 6.3 | 6.2 | ||
MC3R | MC3 | ![]() |
Melanocortin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | α-MSH | Phys | 3 | 1 | 3 | 1 | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 94 | 0 | Activation rate (s-1) | 0.1 | 0.0 | 0.1 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 94 | - | 0 | Activation rate (s-1) | 0.1 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.1 | - | 0.0 | ||
MC3R | MC3 | ![]() |
Melanocortin | A | - | Inoue | TGF𝛼 | 5 | 1 | α-MSH | Phys | 3 | 1 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.5 | - | - | - | - | - | ||
MC3R | MC3 | ![]() |
Melanocortin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 1 | 3 | 1 | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
MC3R | MC3 | ![]() |
Melanocortin | A | - | GproteinDb | merged data | - | - | - | - | - | 3 | 1 | 3 | 1 | Gq/11 | 4 | 2' | 3' | 1' | 4' | 96 | 38 | 97 | 30 | - | - | - | - | - | G15 | 96 | - | - | 0 | 0 | - | - | 75 | 0 | 67 | 0 | 0 | 0 | 97 | 61 | 30 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
MC4R | MC4 | ![]() |
Melanocortin | A | - | Bouvier | GEMTA | 3 | 12 | α-MSH | Phys | 3 | 2 | 2 | 1 | Gq/11 | 4 | 2' | 3' | 1' | 4' | 99 | 71 | 100 | 59 | log(Emax/EC50) | 7.9 | 5.7 | 8.1 | 4.7 | G15 | 99 | - | - | 0 | 0 | - | - | 71 | 0 | 0 | 0 | 0 | 0 | 100 | 0 | 59 | log(Emax/EC50) | 7.9 | - | - | 0.0 | 0.0 | - | - | 5.7 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 8.1 | 0.0 | 4.7 | ||
MC4R | MC4 | ![]() |
Melanocortin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | α-MSH | Phys | 3 | 2 | 2 | 1 | Gs | 3 | 1' | 2' | 3' | nc | 100 | 43 | 25 | 0 | Activation rate (s-1) | 0.5 | 0.2 | 0.1 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 43 | - | 0 | - | - | 25 | - | 0 | Activation rate (s-1) | 0.5 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.1 | - | 0.0 | ||
MC4R | MC4 | ![]() |
Melanocortin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 2 | 2 | 1 | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
MC4R | MC4 | ![]() |
Melanocortin | A | - | GproteinDb | merged data | - | - | - | - | - | 3 | 2 | 2 | 1 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 57 | 62 | 30 | - | - | - | - | - | GsL | 100 | - | - | 0 | 0 | - | - | 71 | 22 | 0 | 0 | 0 | 0 | 62 | 0 | 30 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
MC5R | MC5 | ![]() |
Melanocortin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | α-MSH | Phys | 2 | - | 1 | - | Gq/11 | 2 | 2' | nc | 1' | nc | 97 | 0 | 100 | 0 | Activation rate (s-1) | 0.1 | 0.0 | 0.2 | 0.0 | G15 | 97 | - | - | - | - | - | - | - | 0 | - | 62 | - | - | 100 | - | 0 | Activation rate (s-1) | 0.1 | - | - | - | - | - | - | - | 0.0 | - | 0.1 | - | - | 0.2 | - | 0.0 | ||
MC5R | MC5 | ![]() |
Melanocortin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | 1 | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
MC5R | MC5 | ![]() |
Melanocortin | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | - | 1 | - | Gq/11 | 2 | 2' | nc | 1' | nc | 97 | 0 | 100 | 0 | - | - | - | - | - | G15 | 97 | - | - | - | - | - | - | - | 0 | - | 62 | - | - | 100 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
MTLR | Motilin | ![]() |
Motilin | A | - | Inoue | TGF𝛼 | 5 | 1 | motilin | Phys | - | - | 2 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.7 | - | - | - | - | - | ||
MTLR | Motilin | ![]() |
Motilin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 2 | 1 | Gq/11 | 2 | - | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
MTLR | Motilin | ![]() |
Motilin | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 2 | 1 | Gq/11 | 2 | - | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NMUR1 | NMU1 | ![]() |
Neuromedin U | A | - | Inoue | TGF𝛼 | 5 | 1 | neuromedin U-25 | Phys | - | - | 2 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.6 | - | - | - | - | - | ||
NMUR1 | NMU1 | ![]() |
Neuromedin U | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NMUR1 | NMU1 | ![]() |
Neuromedin U | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NMUR2 | NMU2 | ![]() |
Neuromedin U | A | - | Inoue | TGF𝛼 | 5 | 1 | neuromedin U-25 | Phys | - | - | 2 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.9 | - | - | - | - | - | ||
NMUR2 | NMU2 | ![]() |
Neuromedin U | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NMUR2 | NMU2 | ![]() |
Neuromedin U | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NPFF1 | NPFF1 | ![]() |
Neuropeptide FF/neuropeptide AF | A | - | Bouvier | GEMTA | 3 | 12 | RFRP-3 | Phys | - | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 76 | 69 | log(Emax/EC50) | 0.0 | 9.4 | 7.1 | 6.5 | Gz | 0 | - | - | 85 | 83 | - | - | 100 | 88 | 94 | 0 | 0 | 0 | 76 | 65 | 69 | log(Emax/EC50) | 0.0 | - | - | 7.9 | 7.8 | - | - | 9.4 | 8.2 | 8.8 | 0.0 | 0.0 | 0.0 | 7.1 | 6.1 | 6.5 | ||
NPFF1 | NPFF1 | ![]() |
Neuropeptide FF/neuropeptide AF | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | neuropeptide FF | Phys | - | 3 | 1 | 1 | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 2 | 0 | Activation rate (s-1) | 0.0 | 1.0 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 2 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 1.0 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
NPFF1 | NPFF1 | ![]() |
Neuropeptide FF/neuropeptide AF | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 1 | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPFF1 | NPFF1 | ![]() |
Neuropeptide FF/neuropeptide AF | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 39 | 34 | - | - | - | - | - | Gz | 0 | - | - | 85 | 83 | - | - | 100 | 94 | 94 | 0 | 0 | 0 | 39 | 65 | 34 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NPFF2 | NPFF2 | ![]() |
Neuropeptide FF/neuropeptide AF | A | - | Bouvier | GEMTA | 3 | 12 | neuropeptide FF | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | 7.7 | 0.0 | 0.0 | Gz | 0 | - | - | 84 | 82 | - | - | 100 | 89 | 97 | 0 | 0 | 0 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 6.5 | 6.3 | - | - | 7.7 | 6.9 | 7.5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
NPFF2 | NPFF2 | ![]() |
Neuropeptide FF/neuropeptide AF | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPFF2 | NPFF2 | ![]() |
Neuropeptide FF/neuropeptide AF | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gz | 0 | - | - | 84 | 82 | - | - | 100 | 89 | 97 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NPSR1 | NPS | ![]() |
Neuropeptide S | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | - | 1 | - | Gq/11 | 2 | 2' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPSR1 | NPS | ![]() |
Neuropeptide S | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | 1 | - | Gq/11 | 2 | 2' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NPBW1 | NPBW1 | ![]() |
Neuropeptide W/neuropeptide B | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPBW1 | NPBW1 | ![]() |
Neuropeptide W/neuropeptide B | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NPBW2 | NPBW2 | ![]() |
Neuropeptide W/neuropeptide B | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPBW2 | NPBW2 | ![]() |
Neuropeptide W/neuropeptide B | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NPY1R | Y1 | ![]() |
Neuropeptide Y | A | - | Bouvier | GEMTA | 3 | 12 | neuropeptide Y | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | 9.3 | 0.0 | 0.0 | Gz | 0 | - | - | 97 | 94 | - | - | 100 | 89 | 96 | 0 | 0 | 0 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 9.0 | 8.7 | - | - | 9.3 | 8.2 | 8.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
NPY1R | Y1 | ![]() |
Neuropeptide Y | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | neuropeptide Y | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.2 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
NPY1R | Y1 | ![]() |
Neuropeptide Y | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPY1R | Y1 | ![]() |
Neuropeptide Y | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gz | 0 | - | - | 97 | 94 | - | - | 100 | 94 | 96 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NPY2R | Y2 | ![]() |
Neuropeptide Y | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | neuropeptide Y | Phys | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 2.1 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 2.1 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
NPY2R | Y2 | ![]() |
Neuropeptide Y | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NPY2R | Y2 | ![]() |
Neuropeptide Y | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NPY4R | Y4 | ![]() |
Neuropeptide Y | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | neuropeptide Y | Phys | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.5 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.5 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
NPY4R | Y4 | ![]() |
Neuropeptide Y | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 1 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPY4R | Y4 | ![]() |
Neuropeptide Y | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NPY5R | Y5 | ![]() |
Neuropeptide Y | A | - | Bouvier | GEMTA | 3 | 12 | neuropeptide Y | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | 6.9 | 0.0 | 0.0 | GoA | 0 | - | - | 0 | 0 | - | - | 92 | 100 | 99 | 0 | 0 | 0 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 0.0 | 0.0 | - | - | 6.4 | 6.9 | 6.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
NPY5R | Y5 | ![]() |
Neuropeptide Y | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | neuropeptide Y | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
NPY5R | Y5 | ![]() |
Neuropeptide Y | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NPY5R | Y5 | ![]() |
Neuropeptide Y | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | 0 | 0 | - | - | 92 | 100 | 99 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NTR1 | NTS1 | ![]() |
Neurotensin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | neurotensin | Phys | 1 | 3 | 4 | 2 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 35 | 100 | 29 | Activation rate (s-1) | 0.0 | 1.4 | 4.2 | 1.2 | Gq | 0 | - | - | - | - | - | - | - | 35 | - | 100 | - | - | 22 | - | 29 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 1.4 | - | 4.2 | - | - | 0.9 | - | 1.2 | ||
NTR1 | NTS1 | ![]() |
Neurotensin | A | - | Roth | TRUPATH | 1 | 15 | JMV431 | Surr | 1 | 3 | 4 | 2 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 97 | 100 | 97 | log(Emax/EC50) | 0.0 | 9.0 | 9.3 | 9.0 | G11 | 0 | 0 | 0 | 95 | 96 | 92 | 97 | 97 | 97 | 95 | 95 | 100 | - | 98 | 94 | 97 | log(Emax/EC50) | 0.0 | 0.0 | 0.0 | 8.8 | 8.9 | 8.5 | 8.9 | 8.9 | 9.0 | 8.8 | 8.8 | 9.3 | - | 9.1 | 8.7 | 9.0 | ||
NTR1 | NTS1 | ![]() |
Neurotensin | A | - | Inoue | TGF𝛼 | 5 | 1 | neurotensin | Phys | 1 | 3 | 4 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.3 | - | - | - | - | - | ||
NTR1 | NTS1 | ![]() |
Neurotensin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 3 | 4 | 2 | Gq/11 | 3 | 2' | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NTR1 | NTS1 | ![]() |
Neurotensin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 3 | 4 | 2 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 66 | 100 | 63 | - | - | - | - | - | G11 | 0 | 0 | 0 | 95 | 96 | 92 | 97 | 97 | 66 | 95 | 98 | 100 | - | 60 | 94 | 63 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NTR2 | NTS2 | ![]() |
Neurotensin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NTR2 | NTS2 | ![]() |
Neurotensin | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
OPRD | δ | ![]() |
Opioid | A | - | Bouvier | GEMTA | 3 | 12 | SNC80 | Surr | - | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 72 | 50 | log(Emax/EC50) | 0.0 | 9.3 | 6.7 | 4.7 | Gz | 0 | - | - | 96 | 92 | - | - | 100 | 95 | 99 | 0 | 0 | 57 | 72 | 0 | 50 | log(Emax/EC50) | 0.0 | - | - | 9.0 | 8.6 | - | - | 9.3 | 8.8 | 9.3 | 0.0 | 0.0 | 5.3 | 6.7 | 0.0 | 4.7 | ||
OPRD | δ | ![]() |
Opioid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | [Leu]enkephalin | Phys | - | 3 | 1 | 1 | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 1 | 0 | Activation rate (s-1) | 0.0 | 3.8 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 1 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 3.8 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
OPRD | δ | ![]() |
Opioid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 1 | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
OPRD | δ | ![]() |
Opioid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 36 | 25 | - | - | - | - | - | Gz | 0 | - | - | 96 | 92 | - | - | 100 | 98 | 99 | 0 | 0 | 57 | 36 | 0 | 25 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
OPRK | κ | ![]() |
Opioid | A | - | Bouvier | GEMTA | 3 | 12 | dynorphin A | Phys | - | 3 | 1 | 2 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 74 | 78 | log(Emax/EC50) | 0.0 | 10.2 | 7.5 | 7.9 | GoB | 0 | - | - | 99 | 96 | - | - | 96 | 96 | 100 | 0 | 0 | 0 | 74 | 78 | 0 | log(Emax/EC50) | 0.0 | - | - | 10.0 | 9.7 | - | - | 9.8 | 9.7 | 10.2 | 0.0 | 0.0 | 0.0 | 7.5 | 7.9 | 0.0 | ||
OPRK | κ | ![]() |
Opioid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | dynorphin A | Phys | - | 3 | 1 | 2 | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 4.6 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 4.6 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
OPRK | κ | ![]() |
Opioid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 1 | 2 | Gi/o | 2 | - | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
OPRK | κ | ![]() |
Opioid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 1 | 2 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 37 | 39 | - | - | - | - | - | GoB | 0 | - | - | 99 | 96 | - | - | 96 | 98 | 100 | 0 | 0 | 0 | 37 | 78 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
OPRM | μ | ![]() |
Opioid | A | - | Bouvier | GEMTA | 3 | 12 | DAMGO | Surr | - | 5 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 64 | 0 | log(Emax/EC50) | 0.0 | 8.9 | 5.7 | 0.0 | Gz | 0 | - | - | 92 | 90 | - | - | 100 | 91 | 96 | 0 | 0 | 0 | 64 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.2 | 8.1 | - | - | 8.9 | 8.1 | 8.6 | 0.0 | 0.0 | 0.0 | 5.7 | 0.0 | 0.0 | ||
OPRM | μ | ![]() |
Opioid | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 5 | 2 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.03 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.03 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
OPRM | μ | ![]() |
Opioid | A | - | Lambert | RGB-GDP | 0 | 6 | DAMGO | Surr | - | 5 | 2 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Efficacy | 0.00 | 0.05 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.05 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
OPRM | μ | ![]() |
Opioid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | endomorphin-1 | Phys | - | 5 | 2 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 1.3 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 1.3 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
OPRM | μ | ![]() |
Opioid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 5 | 2 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
OPRM | μ | ![]() |
Opioid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 5 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 16 | 0 | - | - | - | - | - | Gz | 0 | - | - | 97 | 90 | - | - | 100 | 96 | 96 | 0 | 0 | 0 | 32 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
OPRX | NOP | ![]() |
Opioid | A | - | Bouvier | GEMTA | 3 | 12 | nociceptin/orphanin FQ | Phys | - | 3 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 84 | 0 | log(Emax/EC50) | 0.0 | 10.8 | 9.1 | 0.0 | Gz | 0 | - | - | 93 | 89 | - | - | 100 | 91 | 96 | 0 | 0 | 69 | 84 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 10.1 | 9.6 | - | - | 10.8 | 9.8 | 10.3 | 0.0 | 0.0 | 7.4 | 9.1 | 0.0 | 0.0 | ||
OPRX | NOP | ![]() |
Opioid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | nociceptin/orphanin FQ | Phys | - | 3 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 1 | 0 | Activation rate (s-1) | 0.0 | 4.8 | 0.1 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 1 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 4.8 | - | 0.0 | - | - | 0.1 | - | 0.0 | ||
OPRX | NOP | ![]() |
Opioid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 2 | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OPRX | NOP | ![]() |
Opioid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 42 | 0 | - | - | - | - | - | Gz | 0 | - | - | 93 | 89 | - | - | 100 | 96 | 96 | 0 | 0 | 69 | 42 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
OX1R | OX1 | ![]() |
Orexin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | orexin-A | Phys | 1 | 2 | 3 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 30 | 100 | 23 | Activation rate (s-1) | 0.0 | 0.2 | 0.7 | 0.2 | Gq | 0 | - | - | - | - | - | - | - | 30 | - | 100 | - | - | 3 | - | 23 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.2 | - | 0.7 | - | - | 0.0 | - | 0.2 | ||
OX1R | OX1 | ![]() |
Orexin | A | - | Inoue | TGF𝛼 | 5 | 1 | orexin-A | Phys | 1 | 2 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.9 | - | - | - | - | - | ||
OX1R | OX1 | ![]() |
Orexin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 2 | 3 | 1 | Gq/11 | 3 | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OX1R | OX1 | ![]() |
Orexin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 2 | 3 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 30 | 100 | 23 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 30 | - | 100 | - | - | 3 | - | 23 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
OX2R | OX2 | ![]() |
Orexin | A | - | Bouvier | GEMTA | 3 | 12 | orexin-A | Phys | 1 | 3 | 4 | 2 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 92 | 100 | 73 | log(Emax/EC50) | 0.0 | 8.4 | 9.1 | 6.7 | Gq | 0 | - | - | 74 | 69 | - | - | 92 | 78 | 83 | 100 | 100 | 94 | 79 | 73 | 66 | log(Emax/EC50) | 0.0 | - | - | 6.7 | 6.3 | - | - | 8.4 | 7.1 | 7.6 | 9.1 | 9.1 | 8.6 | 7.2 | 6.7 | 6.0 | ||
OX2R | OX2 | ![]() |
Orexin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | orexin-B | Phys | 1 | 3 | 4 | 2 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 11 | 100 | 7 | Activation rate (s-1) | 0.0 | 0.1 | 0.8 | 0.1 | Gq | 0 | - | - | - | - | - | - | - | 11 | - | 100 | - | - | 0 | - | 7 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.8 | - | - | 0.0 | - | 0.1 | ||
OX2R | OX2 | ![]() |
Orexin | A | - | Inoue | TGF𝛼 | 5 | 1 | orexin-A | Phys | 1 | 3 | 4 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.8 | - | - | - | - | - | ||
OX2R | OX2 | ![]() |
Orexin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 3 | 4 | 2 | Gi/o | 3 | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OX2R | OX2 | ![]() |
Orexin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 3 | 4 | 2 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 52 | 100 | 40 | - | - | - | - | - | Gq | 0 | - | - | 74 | 69 | - | - | 92 | 44 | 83 | 100 | 100 | 94 | 40 | 73 | 36 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
QRFPR | QRFP | ![]() |
Peptide P518 | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | - | Gq/11 | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
QRFPR | QRFP | ![]() |
Peptide P518 | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | - | Gq/11 | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
PRLHR | PrRP | ![]() |
Prolactin-releasing peptide | A | - | Inoue | TGF𝛼 | 5 | 1 | PrRP-20 | Phys | - | - | 1 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.8 | - | - | - | - | - | ||
PAR1 | PAR1 | ![]() |
Proteinase-activated | A | - | Bouvier | GEMTA | 3 | 12 | TFLLR-NH2 | Phys | - | 1 | 2 | 1 | G12/13 | 3 | nc | 3' | 2' | 1' | 0 | 86 | 93 | 100 | log(Emax/EC50) | 0.0 | 5.6 | 6.1 | 6.5 | G13 | 0 | - | - | 58 | 66 | - | - | 86 | 73 | 82 | 93 | 93 | 81 | 87 | 0 | 100 | log(Emax/EC50) | 0.0 | - | - | 3.8 | 4.3 | - | - | 5.6 | 4.8 | 5.4 | 6.1 | 6.1 | 5.3 | 5.7 | 0.0 | 6.5 | ||
PAR1 | PAR1 | ![]() |
Proteinase-activated | A | - | Inoue | TGF𝛼 | 5 | 1 | TFLLR-NH2 | Phys | - | 1 | 2 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.1 | - | - | - | - | - | ||
PAR1 | PAR1 | ![]() |
Proteinase-activated | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 2 | 1 | G12/13 | 3 | nc | 3' | 2' | 1' | 0 | 86 | 93 | 100 | - | - | - | - | - | G13 | 0 | - | - | 58 | 66 | - | - | 86 | 73 | 82 | 93 | 93 | 81 | 87 | 0 | 100 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
PAR2 | PAR2 | ![]() |
Proteinase-activated | A | - | Bouvier | GEMTA | 3 | 12 | PAR2 peptide | Phys | - | 1 | 1 | 1 | G12/13 | 3 | nc | 2' | 3' | 1' | 0 | 89 | 86 | 100 | log(Emax/EC50) | 0.0 | 5.9 | 5.6 | 6.6 | G12 | 0 | - | - | 78 | 79 | - | - | 84 | 80 | 89 | 71 | 86 | 77 | 84 | 100 | 97 | log(Emax/EC50) | 0.0 | - | - | 5.1 | 5.2 | - | - | 5.5 | 5.2 | 5.9 | 4.6 | 5.6 | 5.1 | 5.5 | 6.6 | 6.4 | ||
PAR2 | PAR2 | ![]() |
Proteinase-activated | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | 1 | G12/13 | 3 | nc | 2' | 3' | 1' | 0 | 89 | 86 | 100 | - | - | - | - | - | G12 | 0 | - | - | 78 | 79 | - | - | 84 | 80 | 89 | 71 | 86 | 77 | 84 | 100 | 97 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
PAR3 | PAR3 | ![]() |
Proteinase-activated | A | - | Inoue | TGF𝛼 | 5 | 1 | thrombin | Phys | - | - | 1 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.2 | - | - | - | - | - | ||
PAR4 | PAR4 | ![]() |
Proteinase-activated | A | - | Inoue | TGF𝛼 | 5 | 1 | thrombin | Phys | - | - | 1 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.4 | - | - | - | - | - | ||
RXFP1 | RXFP1 | ![]() |
Relaxin family peptide | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 1 | - | - | Gi/o | 2 | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
RXFP1 | RXFP1 | ![]() |
Relaxin family peptide | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | - | - | Gi/o | 2 | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
RXFP2 | RXFP2 | ![]() |
Relaxin family peptide | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 1 | - | - | Gi/o | 2 | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
RXFP2 | RXFP2 | ![]() |
Relaxin family peptide | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | - | - | Gi/o | 2 | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
RL3R1 | RXFP3 | ![]() |
Relaxin family peptide | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
RL3R1 | RXFP3 | ![]() |
Relaxin family peptide | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
RL3R2 | RXFP4 | ![]() |
Relaxin family peptide | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
RL3R2 | RXFP4 | ![]() |
Relaxin family peptide | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
SSR1 | SST1 | ![]() |
Somatostatin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | SRIF-14 | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.2 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
SSR1 | SST1 | ![]() |
Somatostatin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
SSR1 | SST1 | ![]() |
Somatostatin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
SSR2 | SST2 | ![]() |
Somatostatin | A | - | Bouvier | GEMTA | 3 | 12 | SRIF-14 | Phys | - | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 75 | 67 | log(Emax/EC50) | 0.0 | 10.7 | 8.0 | 7.1 | Gz | 0 | - | - | 96 | 93 | - | - | 100 | 90 | 96 | 62 | 0 | 70 | 75 | 67 | 0 | log(Emax/EC50) | 0.0 | - | - | 10.2 | 10.0 | - | - | 10.7 | 9.6 | 10.2 | 6.6 | 0.0 | 7.5 | 8.0 | 7.1 | 0.0 | ||
SSR2 | SST2 | ![]() |
Somatostatin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | SRIF-14 | Phys | - | 3 | 1 | 1 | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 1.8 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 1.8 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
SSR2 | SST2 | ![]() |
Somatostatin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 1 | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
SSR2 | SST2 | ![]() |
Somatostatin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 38 | 34 | - | - | - | - | - | Gz | 0 | - | - | 96 | 93 | - | - | 100 | 95 | 96 | 31 | 0 | 70 | 38 | 67 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
SSR3 | SST3 | ![]() |
Somatostatin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | SRIF-14 | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 2 | 0 | Activation rate (s-1) | 0.0 | 2.3 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 2 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 2.3 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
SSR3 | SST3 | ![]() |
Somatostatin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
SSR3 | SST3 | ![]() |
Somatostatin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 2 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 2 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
SSR4 | SST4 | ![]() |
Somatostatin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | SRIF-14 | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.2 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
SSR4 | SST4 | ![]() |
Somatostatin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
SSR4 | SST4 | ![]() |
Somatostatin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
SSR5 | SST5 | ![]() |
Somatostatin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | SRIF-14 | Phys | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 1 | 0 | Activation rate (s-1) | 0.0 | 4.4 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 1 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 4.4 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
SSR5 | SST5 | ![]() |
Somatostatin | A | - | Inoue | TGF𝛼 | 5 | 1 | SRIF-14 | Phys | - | 2 | 1 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.3 | - | - | - | - | - | ||
SSR5 | SST5 | ![]() |
Somatostatin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
SSR5 | SST5 | ![]() |
Somatostatin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 1 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 1 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NK1R | NK1 | ![]() |
Tachykinin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | substance P | Phys | 1 | 1 | 3 | 1 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 6 | 100 | 48 | Activation rate (s-1) | 0.0 | 0.3 | 4.2 | 2.0 | Gq | 0 | - | - | - | - | - | - | - | 6 | - | 100 | - | - | 4 | - | 48 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.3 | - | 4.2 | - | - | 0.2 | - | 2.0 | ||
NK1R | NK1 | ![]() |
Tachykinin | A | - | Inoue | TGF𝛼 | 5 | 1 | substance P | Phys | 1 | 1 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.5 | - | - | - | - | - | ||
NK1R | NK1 | ![]() |
Tachykinin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | 3 | 1 | Gq/11 | 2 | 1' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NK1R | NK1 | ![]() |
Tachykinin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | 3 | 1 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 6 | 100 | 48 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 6 | - | 100 | - | - | 4 | - | 48 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NK2R | NK2 | ![]() |
Tachykinin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | neurokinin A | Phys | 1 | 1 | 3 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 29 | 100 | 7 | Activation rate (s-1) | 0.0 | 1.4 | 4.6 | 0.3 | Gq | 0 | - | - | - | - | - | - | - | 29 | - | 100 | - | - | 10 | - | 7 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 1.4 | - | 4.6 | - | - | 0.5 | - | 0.3 | ||
NK2R | NK2 | ![]() |
Tachykinin | A | - | Inoue | TGF𝛼 | 5 | 1 | neurokinin B | Phys | 1 | 1 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.5 | - | - | - | - | - | ||
NK2R | NK2 | ![]() |
Tachykinin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | 3 | 1 | Gq/11 | 2 | 1' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NK2R | NK2 | ![]() |
Tachykinin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | 3 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 29 | 100 | 7 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 29 | - | 100 | - | - | 10 | - | 7 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NK3R | NK3 | ![]() |
Tachykinin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | neurokinin B | Phys | - | 1 | 3 | 1 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 7 | 100 | 67 | Activation rate (s-1) | 0.0 | 0.2 | 2.9 | 1.9 | Gq | 0 | - | - | - | - | - | - | - | 7 | - | 100 | - | - | 15 | - | 67 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.2 | - | 2.9 | - | - | 0.4 | - | 1.9 | ||
NK3R | NK3 | ![]() |
Tachykinin | A | - | Inoue | TGF𝛼 | 5 | 1 | neurokinin A | Phys | - | 1 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.2 | - | - | - | - | - | ||
NK3R | NK3 | ![]() |
Tachykinin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 3 | 1 | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
NK3R | NK3 | ![]() |
Tachykinin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 3 | 1 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 7 | 100 | 67 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 7 | - | 100 | - | - | 15 | - | 67 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
GPR3 | GPR3 | ![]() |
A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
GPR3 | GPR3 | ![]() |
A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | - | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
TRFR | TRH1 | ![]() |
Thyrotropin-releasing hormone | A | - | Inoue | TGF𝛼 | 5 | 1 | TRH | Phys | - | - | 2 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.6 | - | - | - | - | - | ||
TRFR | TRH1 | ![]() |
Thyrotropin-releasing hormone | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
TRFR | TRH1 | ![]() |
Thyrotropin-releasing hormone | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
UR2R | UT | ![]() |
Urotensin | A | - | Inoue | TGF𝛼 | 5 | 1 | urotensin-II | Phys | - | - | 2 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.2 | - | - | - | - | - | ||
UR2R | UT | ![]() |
Urotensin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
UR2R | UT | ![]() |
Urotensin | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
V1AR | V1A | ![]() |
Vasopressin and oxytocin | A | - | Bouvier | GEMTA | 3 | 12 | vasopressin | Phys | - | 2 | 4 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 80 | 100 | 0 | log(Emax/EC50) | 0.0 | 7.0 | 8.7 | 0.0 | G11 | 0 | - | - | 78 | 77 | - | - | 80 | 79 | 78 | 98 | 100 | 93 | 91 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 6.8 | 6.7 | - | - | 7.0 | 6.9 | 6.8 | 8.5 | 8.7 | 8.1 | 7.9 | 0.0 | 0.0 | ||
V1AR | V1A | ![]() |
Vasopressin and oxytocin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | vasopressin | Phys | - | 2 | 4 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 17 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.7 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 17 | - | 100 | - | - | 8 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.7 | - | - | 0.1 | - | 0.0 | ||
V1AR | V1A | ![]() |
Vasopressin and oxytocin | A | - | Inoue | TGF𝛼 | 5 | 1 | vasopressin | Phys | - | 2 | 4 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 10.1 | - | - | - | - | - | ||
V1AR | V1A | ![]() |
Vasopressin and oxytocin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 4 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
V1AR | V1A | ![]() |
Vasopressin and oxytocin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 4 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 48 | 100 | 0 | - | - | - | - | - | G11 | 0 | - | - | 78 | 77 | - | - | 80 | 48 | 78 | 99 | 100 | 93 | 50 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
V1BR | V1B | ![]() |
Vasopressin and oxytocin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | vasopressin | Phys | - | 1 | 3 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 21 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.6 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 21 | - | 100 | - | - | 9 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.6 | - | - | 0.1 | - | 0.0 | ||
V1BR | V1B | ![]() |
Vasopressin and oxytocin | A | - | Inoue | TGF𝛼 | 5 | 1 | vasopressin | Phys | - | 1 | 3 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.5 | - | - | - | - | - | ||
V1BR | V1B | ![]() |
Vasopressin and oxytocin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 3 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
V1BR | V1B | ![]() |
Vasopressin and oxytocin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 3 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 21 | 100 | 0 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 21 | - | 100 | - | - | 9 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
V2R | V2 | ![]() |
Vasopressin and oxytocin | A | - | Bouvier | GEMTA | 3 | 12 | vasopressin | Phys | 4 | 3 | 4 | 2 | Gs | 4 | 1' | 4' | 2' | 3' | 100 | 60 | 88 | 77 | log(Emax/EC50) | 10.1 | 6.1 | 8.9 | 7.8 | GsL | 100 | - | - | 60 | 51 | - | - | 0 | 55 | 0 | 69 | 70 | 65 | 88 | 0 | 77 | log(Emax/EC50) | 10.1 | - | - | 6.1 | 5.1 | - | - | 0.0 | 5.5 | 0.0 | 6.9 | 7.1 | 6.5 | 8.9 | 0.0 | 7.8 | ||
V2R | V2 | ![]() |
Vasopressin and oxytocin | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 4 | 3 | 4 | 2 | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
V2R | V2 | ![]() |
Vasopressin and oxytocin | A | - | Lambert | RGB-GDP | 0 | 6 | vasopressin | Phys | 4 | 3 | 4 | 2 | Gs | 3 | 1' | 2' | 3' | nc | 100 | 42 | 33 | 0 | Efficacy | 0.06 | 0.03 | 0.02 | 0.00 | GsL | 100 | - | - | 42 | - | - | - | - | - | - | 33 | - | - | - | 0 | - | Efficacy | 0.06 | - | - | 0.03 | - | - | - | - | - | - | 0.02 | - | - | - | 0.00 | - | ||
V2R | V2 | ![]() |
Vasopressin and oxytocin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | vasopressin | Phys | 4 | 3 | 4 | 2 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 6 | 41 | 5 | Activation rate (s-1) | 1.4 | 0.1 | 0.6 | 0.1 | GsL | 100 | - | - | - | - | - | - | - | 6 | - | 11 | - | - | 41 | - | 5 | Activation rate (s-1) | 1.4 | - | - | - | - | - | - | - | 0.1 | - | 0.2 | - | - | 0.6 | - | 0.1 | ||
V2R | V2 | ![]() |
Vasopressin and oxytocin | A | - | Inoue | TGF𝛼 | 5 | 1 | vasopressin | Phys | 4 | 3 | 4 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.5 | - | - | - | - | - | ||
V2R | V2 | ![]() |
Vasopressin and oxytocin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 4 | 3 | 4 | 2 | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
V2R | V2 | ![]() |
Vasopressin and oxytocin | A | - | GproteinDb | merged data | - | - | - | - | - | 4 | 3 | 4 | 2 | Gs | 4 | 1' | 3' | 2' | 4' | 75 | 27 | 40 | 20 | - | - | - | - | - | GsL | 75 | - | - | 34 | 51 | - | - | 0 | 30 | 0 | 28 | 70 | 65 | 64 | 0 | 41 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
OXYR | OT | ![]() |
Vasopressin and oxytocin | A | - | Bouvier | GEMTA | 3 | 12 | oxytocin | Phys | - | 3 | 5 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | log(Emax/EC50) | 0.0 | 0.0 | 7.6 | 0.0 | Gq | 0 | - | - | 0 | 0 | - | - | 0 | 0 | 0 | 100 | 100 | 90 | 96 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 0.0 | 0.0 | - | - | 0.0 | 0.0 | 0.0 | 7.6 | 7.6 | 6.8 | 7.3 | 0.0 | 0.0 | ||
OXYR | OT | ![]() |
Vasopressin and oxytocin | A | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | 3 | 5 | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |
OXYR | OT | ![]() |
Vasopressin and oxytocin | A | - | Lambert | RGB-GDP | 0 | 6 | - | oxytocin | Phys | - | 3 | 5 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 69 | 100 | 0 | Efficacy | 0.00 | 0.03 | 0.04 | 0.00 | Gq | 0 | - | - | 69 | - | - | - | - | - | - | 100 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.03 | - | - | - | - | - | - | 0.04 | - | - | - | 0.00 | - | |
OXYR | OT | ![]() |
Vasopressin and oxytocin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | oxytocin | Phys | - | 3 | 5 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 13 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.6 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 13 | - | 100 | - | - | 17 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.6 | - | - | 0.1 | - | 0.0 | ||
OXYR | OT | ![]() |
Vasopressin and oxytocin | A | - | Inoue | TGF𝛼 | 5 | 1 | oxytocin | Phys | - | 3 | 5 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.0 | - | - | - | - | - | ||
OXYR | OT | ![]() |
Vasopressin and oxytocin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 5 | - | Gq/11 | 2 | - | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
OXYR | OT | ![]() |
Vasopressin and oxytocin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 5 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 20 | 75 | 0 | - | - | - | - | - | G11 | 0 | - | - | 23 | 0 | - | - | 0 | 6 | 0 | 75 | 100 | 90 | 56 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CML1 | Chemerin | ![]() |
Chemerin receptor | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CML1 | Chemerin | ![]() |
Chemerin receptor | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCR1 | CCR1 | ![]() |
Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCR1 | CCR1 | ![]() |
Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCR2 | CCR2 | ![]() |
Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCR2 | CCR2 | ![]() |
Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCR3 | CCR3 | ![]() |
Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCR3 | CCR3 | ![]() |
Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCR4 | CCR4 | ![]() |
Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCR4 | CCR4 | ![]() |
Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCR5 | CCR5 | ![]() |
Chemokine | A | - | Bouvier | GEMTA | 3 | 12 | CCL3 | Phys | - | 2 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 70 | 0 | log(Emax/EC50) | 0.0 | 9.1 | 6.4 | 0.0 | Gz | 0 | - | - | 98 | 96 | - | - | 100 | 94 | 97 | 0 | 0 | 0 | 70 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.9 | 8.7 | - | - | 9.1 | 8.5 | 8.8 | 0.0 | 0.0 | 0.0 | 6.4 | 0.0 | 0.0 | ||
CCR5 | CCR5 | ![]() |
Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCR5 | CCR5 | ![]() |
Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 70 | 0 | - | - | - | - | - | Gz | 0 | - | - | 98 | 96 | - | - | 100 | 94 | 97 | 0 | 0 | 0 | 70 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCR6 | CCR6 | ![]() |
Chemokine | A | - | Bouvier | GEMTA | 3 | 12 | CCL2 | Phys | - | 2 | 1 | 1 | G12/13 | 3 | nc | 2' | 3' | 1' | 0 | 95 | 95 | 100 | log(Emax/EC50) | 0.0 | 8.2 | 8.2 | 8.6 | G12 | 0 | - | - | 86 | 94 | - | - | 95 | 83 | 91 | 0 | 0 | 0 | 95 | 100 | 0 | log(Emax/EC50) | 0.0 | - | - | 7.3 | 8.1 | - | - | 8.2 | 7.1 | 7.8 | 0.0 | 0.0 | 0.0 | 8.2 | 8.6 | 0.0 | ||
CCR6 | CCR6 | ![]() |
Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | 1 | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCR6 | CCR6 | ![]() |
Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | 1 | G12/13 | 3 | nc | 2' | 3' | 1' | 0 | 95 | 95 | 100 | - | - | - | - | - | G12 | 0 | - | - | 86 | 94 | - | - | 95 | 83 | 91 | 0 | 0 | 0 | 95 | 100 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCR7 | CCR7 | ![]() |
Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR7 | CCR7 | ![]() |
Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCR8 | CCR8 | ![]() |
Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCR8 | CCR8 | ![]() |
Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCR9 | CCR9 | ![]() |
Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCR9 | CCR9 | ![]() |
Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCR10 | CCR10 | ![]() |
Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CCR10 | CCR10 | ![]() |
Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CXCR1 | CXCR1 | ![]() |
Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CXCR1 | CXCR1 | ![]() |
Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CXCR2 | CXCR2 | ![]() |
Chemokine | A | - | Bouvier | GEMTA | 3 | 12 | CXCL8 | Phys | - | 2 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 87 | 0 | log(Emax/EC50) | 0.0 | 9.4 | 8.2 | 0.0 | GoB | 0 | - | - | 99 | 99 | - | - | 91 | 97 | 100 | 0 | 0 | 0 | 87 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 9.4 | 9.3 | - | - | 8.6 | 9.1 | 9.4 | 0.0 | 0.0 | 0.0 | 8.2 | 0.0 | 0.0 | ||
CXCR2 | CXCR2 | ![]() |
Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 1 | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CXCR2 | CXCR2 | ![]() |
Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 87 | 0 | - | - | - | - | - | GoB | 0 | - | - | 99 | 99 | - | - | 91 | 97 | 100 | 0 | 0 | 0 | 87 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CXCR3 | CXCR3 | ![]() |
Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CXCR3 | CXCR3 | ![]() |
Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CXCR4 | CXCR4 | ![]() |
Chemokine | A | - | Bouvier | GEMTA | 3 | 12 | CXCL12α | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | 8.5 | 0.0 | 0.0 | Gi2 | 0 | - | - | 97 | 100 | - | - | 88 | 92 | 95 | 0 | 0 | 0 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.3 | 8.5 | - | - | 7.5 | 7.8 | 8.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
CXCR4 | CXCR4 | ![]() |
Chemokine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | CXCL12α | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 7 | 0 | Activation rate (s-1) | 0.0 | 0.3 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 7 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.3 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
CXCR4 | CXCR4 | ![]() |
Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CXCR4 | CXCR4 | ![]() |
Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | - | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 4 | 0 | - | - | - | - | - | Gi2 | 0 | - | - | 97 | 100 | - | - | 88 | 96 | 95 | 0 | 0 | 0 | 4 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CXCR5 | CXCR5 | ![]() |
Chemokine | A | - | Bouvier | GEMTA | 3 | 12 | CXCL13 | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | 8.2 | 0.0 | 0.0 | GoB | 0 | - | - | 95 | 94 | - | - | 99 | 96 | 100 | 0 | 0 | 0 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 7.7 | 7.6 | - | - | 8.1 | 7.8 | 8.2 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
CXCR5 | CXCR5 | ![]() |
Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CXCR5 | CXCR5 | ![]() |
Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoB | 0 | - | - | 95 | 94 | - | - | 99 | 96 | 100 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CXCR6 | CXCR6 | ![]() |
Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CXCR6 | CXCR6 | ![]() |
Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CX3C1 | CX3CR1 | ![]() |
Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CX3C1 | CX3CR1 | ![]() |
Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
XCR1 | XCR1 | ![]() |
Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
XCR1 | XCR1 | ![]() |
Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
FSHR | FSH | ![]() |
Glycoprotein hormone | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | 1 | - | Gq/11 | 3 | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
FSHR | FSH | ![]() |
Glycoprotein hormone | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | 1 | - | Gq/11 | 3 | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
LSHR | LH | ![]() |
Glycoprotein hormone | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | - | 1 | - | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
LSHR | LH | ![]() |
Glycoprotein hormone | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | 1 | - | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
TSHR | TSH | ![]() |
Glycoprotein hormone | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | 1 | - | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
TSHR | TSH | ![]() |
Glycoprotein hormone | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | 1 | - | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
PKR1 | PKR1 | ![]() |
Prokineticin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | 1 | - | Gq/11 | 2 | 2' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
PKR1 | PKR1 | ![]() |
Prokineticin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | 1 | - | Gq/11 | 2 | 2' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
PKR2 | PKR2 | ![]() |
Prokineticin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 1 | 1 | - | Gq/11 | 3 | 2' | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PKR2 | PKR2 | ![]() |
Prokineticin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | 1 | - | Gq/11 | 3 | 2' | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
FFAR1 | FFA1 | ![]() |
Free fatty acid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | 1 | - | Gq/11 | 3 | 2' | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
FFAR1 | FFA1 | ![]() |
Free fatty acid | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | 1 | - | Gq/11 | 3 | 2' | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
FFAR2 | FFA2 | ![]() |
Free fatty acid | A | - | Bouvier | GEMTA | 3 | 12 | propanoic acid | Phys | - | 2 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 95 | 0 | log(Emax/EC50) | 0.0 | 4.3 | 4.1 | 0.0 | Gi1 | 0 | - | - | 100 | 95 | - | - | 0 | 0 | 0 | 87 | 90 | 95 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 4.3 | 4.1 | - | - | 0.0 | 0.0 | 0.0 | 3.7 | 3.9 | 4.1 | 0.0 | 0.0 | 0.0 | ||
FFAR2 | FFA2 | ![]() |
Free fatty acid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 2 | - | Gq/11 | 2 | - | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FFAR2 | FFA2 | ![]() |
Free fatty acid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 95 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 95 | - | - | 0 | 0 | 0 | 87 | 90 | 95 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
FFAR3 | FFA3 | ![]() |
Free fatty acid | A | - | Bouvier | GEMTA | 3 | 12 | propanoic acid | Phys | - | 2 | - | 1 | Gi/o | 2 | nc | 1' | nc | 2' | 0 | 100 | 0 | 86 | log(Emax/EC50) | 0.0 | 5.0 | 0.0 | 4.3 | GoB | 0 | - | - | 98 | 99 | - | - | 89 | 97 | 100 | 0 | 0 | 0 | 0 | 86 | 78 | log(Emax/EC50) | 0.0 | - | - | 4.8 | 4.9 | - | - | 4.4 | 4.8 | 5.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.3 | 3.9 | ||
FFAR3 | FFA3 | ![]() |
Free fatty acid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FFAR3 | FFA3 | ![]() |
Free fatty acid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | 1 | Gi/o | 2 | nc | 1' | nc | 2' | 0 | 100 | 0 | 86 | - | - | - | - | - | GoB | 0 | - | - | 98 | 99 | - | - | 89 | 97 | 100 | 0 | 0 | 0 | 0 | 86 | 78 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
FFAR4 | FFA4 | ![]() |
Free fatty acid | A | - | Bouvier | GEMTA | 3 | 12 | α-linolenic acid | Phys | - | 1 | 2 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 92 | 100 | 78 | log(Emax/EC50) | 0.0 | 4.8 | 5.2 | 4.0 | G15 | 0 | - | - | 91 | 91 | - | - | 0 | 86 | 92 | 84 | 87 | 96 | 100 | 0 | 78 | log(Emax/EC50) | 0.0 | - | - | 4.7 | 4.7 | - | - | 0.0 | 4.4 | 4.8 | 4.4 | 4.5 | 4.9 | 5.2 | 0.0 | 4.0 | ||
FFAR4 | FFA4 | ![]() |
Free fatty acid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 2 | 1 | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FFAR4 | FFA4 | ![]() |
Free fatty acid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 2 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 92 | 100 | 78 | - | - | - | - | - | G15 | 0 | - | - | 91 | 91 | - | - | 0 | 86 | 92 | 84 | 87 | 96 | 100 | 0 | 78 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
LT4R1 | BLT1 | ![]() |
Leukotriene | A | - | Bouvier | GEMTA | 3 | 12 | LTB4 | Phys | - | 2 | 3 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 97 | 85 | log(Emax/EC50) | 0.0 | 10.1 | 9.7 | 8.6 | GoB | 0 | - | - | 99 | 99 | - | - | 91 | 95 | 100 | 59 | 53 | 65 | 97 | 85 | 85 | log(Emax/EC50) | 0.0 | - | - | 10.0 | 10.0 | - | - | 9.2 | 9.5 | 10.1 | 5.9 | 5.4 | 6.5 | 9.7 | 8.6 | 8.6 | ||
LT4R1 | BLT1 | ![]() |
Leukotriene | A | - | Inoue | TGF𝛼 | 5 | 1 | LTB4 | Phys | - | 2 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.3 | - | - | - | - | - | ||
LT4R1 | BLT1 | ![]() |
Leukotriene | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 3 | 1 | Gq/11 | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
LT4R1 | BLT1 | ![]() |
Leukotriene | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 3 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 97 | 85 | - | - | - | - | - | GoB | 0 | - | - | 99 | 99 | - | - | 91 | 95 | 100 | 59 | 53 | 65 | 97 | 85 | 85 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
LT4R2 | BLT2 | ![]() |
Leukotriene | A | - | Bouvier | GEMTA | 3 | 12 | LTB4 | Phys | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | 8.4 | 0.0 | 0.0 | Gi1 | 0 | - | - | 100 | 98 | - | - | 76 | 92 | 97 | 0 | 0 | 0 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.4 | 8.2 | - | - | 6.4 | 7.8 | 8.2 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
LT4R2 | BLT2 | ![]() |
Leukotriene | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 1 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
LT4R2 | BLT2 | ![]() |
Leukotriene | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 98 | - | - | 76 | 92 | 97 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CLTR1 | CysLT1 | ![]() |
Leukotriene | A | - | Bouvier | GEMTA | 3 | 12 | LTB4 | Phys | - | 2 | 3 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 89 | 0 | log(Emax/EC50) | 0.0 | 8.3 | 7.3 | 0.0 | Gz | 0 | - | - | 98 | 98 | - | - | 100 | 92 | 98 | 85 | 84 | 80 | 89 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.2 | 8.1 | - | - | 8.3 | 7.6 | 8.1 | 7.0 | 6.9 | 6.6 | 7.3 | 0.0 | 0.0 | ||
CLTR1 | CysLT1 | ![]() |
Leukotriene | A | - | Inoue | TGF𝛼 | 5 | 1 | LTD4 | Phys | - | 2 | 3 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.0 | - | - | - | - | - | ||
CLTR1 | CysLT1 | ![]() |
Leukotriene | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 3 | - | Gq/11 | 2 | - | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CLTR1 | CysLT1 | ![]() |
Leukotriene | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 3 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 89 | 0 | - | - | - | - | - | Gz | 0 | - | - | 98 | 98 | - | - | 100 | 92 | 98 | 85 | 84 | 80 | 89 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CLTR2 | CysLT2 | ![]() |
Leukotriene | A | - | Bouvier | GEMTA | 3 | 12 | LTB4 | Phys | - | 2 | 3 | 1 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 90 | 100 | 94 | log(Emax/EC50) | 0.0 | 8.4 | 9.3 | 8.8 | G15 | 0 | - | - | 74 | 71 | - | - | 90 | 73 | 80 | 91 | 90 | 94 | 100 | 94 | 87 | log(Emax/EC50) | 0.0 | - | - | 6.9 | 6.6 | - | - | 8.4 | 6.8 | 7.5 | 8.5 | 8.4 | 8.7 | 9.3 | 8.8 | 8.1 | ||
CLTR2 | CysLT2 | ![]() |
Leukotriene | A | - | Inoue | TGF𝛼 | 5 | 1 | LTD4 | Phys | - | 2 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.2 | - | - | - | - | - | ||
CLTR2 | CysLT2 | ![]() |
Leukotriene | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | 3 | 1 | Gq/11 | 2 | - | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CLTR2 | CysLT2 | ![]() |
Leukotriene | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 3 | 1 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 90 | 100 | 94 | - | - | - | - | - | G15 | 0 | - | - | 74 | 71 | - | - | 90 | 73 | 80 | 91 | 90 | 94 | 100 | 94 | 87 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
OXER1 | OXE | ![]() |
Leukotriene | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OXER1 | OXE | ![]() |
Leukotriene | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
LPAR1 | LPA1 | ![]() |
Lysophospholipid (LPA) | A | - | Bouvier | GEMTA | 3 | 12 | 2-oleoyl-LPA | Phys | - | 2 | 3 | 2 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 73 | 93 | log(Emax/EC50) | 0.0 | 8.3 | 6.1 | 7.8 | Gi1 | 0 | - | - | 100 | 0 | - | - | 0 | 95 | 0 | 73 | 66 | 55 | 69 | 0 | 93 | log(Emax/EC50) | 0.0 | - | - | 8.3 | 0.0 | - | - | 0.0 | 7.9 | 0.0 | 6.1 | 5.5 | 4.6 | 5.8 | 0.0 | 7.8 | ||
LPAR1 | LPA1 | ![]() |
Lysophospholipid (LPA) | A | - | Inoue | TGF𝛼 | 5 | 1 | LPA | Phys | - | 2 | 3 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.0 | - | - | - | - | - | ||
LPAR1 | LPA1 | ![]() |
Lysophospholipid (LPA) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | 3 | 2 | G12/13 | 3 | - | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
LPAR1 | LPA1 | ![]() |
Lysophospholipid (LPA) | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 3 | 2 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 73 | 93 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 0 | - | - | 0 | 95 | 0 | 73 | 66 | 55 | 69 | 0 | 93 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
LPAR2 | LPA2 | ![]() |
Lysophospholipid (LPA) | A | - | Bouvier | GEMTA | 3 | 12 | 2-oleoyl-LPA | Phys | - | 2 | 3 | 2 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 81 | 97 | log(Emax/EC50) | 0.0 | 8.5 | 6.9 | 8.2 | GoB | 0 | - | - | 94 | 95 | - | - | 85 | 91 | 100 | 80 | 78 | 81 | 73 | 0 | 97 | log(Emax/EC50) | 0.0 | - | - | 8.0 | 8.0 | - | - | 7.2 | 7.7 | 8.5 | 6.7 | 6.6 | 6.9 | 6.1 | 0.0 | 8.2 | ||
LPAR2 | LPA2 | ![]() |
Lysophospholipid (LPA) | A | - | Inoue | TGF𝛼 | 5 | 1 | LPA | Phys | - | 2 | 3 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.6 | - | - | - | - | - | ||
LPAR2 | LPA2 | ![]() |
Lysophospholipid (LPA) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | 3 | 2 | Gi/o | 3 | - | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
LPAR2 | LPA2 | ![]() |
Lysophospholipid (LPA) | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 3 | 2 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 81 | 97 | - | - | - | - | - | GoB | 0 | - | - | 94 | 95 | - | - | 85 | 91 | 100 | 80 | 78 | 81 | 73 | 0 | 97 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
LPAR3 | LPA3 | ![]() |
Lysophospholipid (LPA) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
LPAR3 | LPA3 | ![]() |
Lysophospholipid (LPA) | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
LPAR4 | LPA4 | ![]() |
Lysophospholipid (LPA) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 1 | 1 | 1 | G12/13 | 4 | 1' | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
LPAR4 | LPA4 | ![]() |
Lysophospholipid (LPA) | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | 1 | 1 | G12/13 | 4 | 1' | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
LPAR5 | LPA5 | ![]() |
Lysophospholipid (LPA) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 1 | 1 | Gq/11 | 2 | - | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
LPAR5 | LPA5 | ![]() |
Lysophospholipid (LPA) | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 1 | 1 | Gq/11 | 2 | - | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
LPAR6 | LPA6 | ![]() |
Lysophospholipid (LPA) | A | - | Roth | TRUPATH | 1 | 15 | LPA | Phys | 2 | 2 | - | 2 | Gs | 3 | 1' | 3' | nc | 2' | 100 | 9 | 0 | 10 | log(Emax/EC50) | 75.4 | 7.1 | 0.0 | 7.4 | G13 | 0 | 75 | 0 | 78 | 85 | 72 | 87 | 89 | 95 | 96 | 0 | 0 | - | 0 | 98 | 100 | log(Emax/EC50) | 0.0 | 5.6 | 0.0 | 5.7 | 6.2 | 5.3 | 6.4 | 6.6 | 7.0 | 7.1 | 0.0 | 0.0 | - | 0.0 | 7.2 | 7.4 | ||
LPAR6 | LPA6 | ![]() |
Lysophospholipid (LPA) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 2 | 2 | - | 2 | Gs | 3 | 1' | 1' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
LPAR6 | LPA6 | ![]() |
Lysophospholipid (LPA) | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | 2 | - | 2 | Gs | 3 | 1' | 3' | nc | 2' | 100 | 9 | 0 | 10 | - | - | - | - | - | G13 | 0 | 75 | 0 | 78 | 85 | 72 | 87 | 89 | 95 | 96 | 0 | 0 | - | 0 | 98 | 100 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
S1PR1 | S1P1 | ![]() |
Lysophospholipid (S1P) | A | - | Bouvier | GEMTA | 3 | 12 | sphingosine 1-phosphate | Phys | - | 2 | 1 | 1 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 79 | 86 | log(Emax/EC50) | 0.0 | 7.3 | 5.8 | 6.3 | Gi1 | 0 | - | - | 100 | 96 | - | - | 0 | 91 | 95 | 0 | 0 | 0 | 79 | 86 | 86 | log(Emax/EC50) | 0.0 | - | - | 7.3 | 7.0 | - | - | 0.0 | 6.6 | 7.0 | 0.0 | 0.0 | 0.0 | 5.8 | 6.3 | 6.3 | ||
S1PR1 | S1P1 | ![]() |
Lysophospholipid (S1P) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 1 | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
S1PR1 | S1P1 | ![]() |
Lysophospholipid (S1P) | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | 1 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 79 | 86 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 96 | - | - | 0 | 91 | 95 | 0 | 0 | 0 | 79 | 86 | 86 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
S1PR2 | S1P2 | ![]() |
Lysophospholipid (S1P) | A | - | Inoue | TGF𝛼 | 5 | 1 | sphingosine 1-phosphate | Phys | 1 | - | 2 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.2 | - | - | - | - | - | ||
S1PR2 | S1P2 | ![]() |
Lysophospholipid (S1P) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | 2 | 1 | Gs | 3 | 1' | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
S1PR2 | S1P2 | ![]() |
Lysophospholipid (S1P) | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | 2 | 1 | Gs | 3 | 1' | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
S1PR3 | S1P3 | ![]() |
Lysophospholipid (S1P) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 1 | 1 | Gi/o | 3 | - | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
S1PR3 | S1P3 | ![]() |
Lysophospholipid (S1P) | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | 1 | Gi/o | 3 | - | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
S1PR4 | S1P4 | ![]() |
Lysophospholipid (S1P) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | 1 | Gi/o | 2 | - | 1' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
S1PR4 | S1P4 | ![]() |
Lysophospholipid (S1P) | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | 1 | Gi/o | 2 | - | 1' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
S1PR5 | S1P5 | ![]() |
Lysophospholipid (S1P) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | 1 | Gi/o | 2 | - | 1' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
S1PR5 | S1P5 | ![]() |
Lysophospholipid (S1P) | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | 1 | Gi/o | 2 | - | 1' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CNR1 | CB1 | ![]() |
Cannabinoid | A | - | Bouvier | GEMTA | 3 | 12 | WIN55212-2 | Surr | 3 | 5 | 2 | 3 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 100 | 100 | 91 | log(Emax/EC50) | 0.0 | 7.6 | 7.6 | 6.9 | Gi1 | 0 | - | - | 100 | 93 | - | - | 92 | 97 | 99 | 0 | 0 | 48 | 100 | 91 | 88 | log(Emax/EC50) | 0.0 | - | - | 7.6 | 7.1 | - | - | 7.0 | 7.4 | 7.5 | 0.0 | 0.0 | 3.6 | 7.6 | 6.9 | 6.7 | ||
CNR1 | CB1 | ![]() |
Cannabinoid | A | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | 3 | 5 | 2 | 3 | Gi/o | 3 | 3' | 1' | nc | 2' | 34 | 100 | 0 | 41 | Econstitutive | 0.02 | 0.06 | 0.00 | 0.02 | Gi1 | 34 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 41 | - | Econstitutive | 0.02 | - | - | 0.06 | - | - | - | - | - | - | 0.00 | - | - | - | 0.02 | - | |
CNR1 | CB1 | ![]() |
Cannabinoid | A | - | Lambert | RGB-GDP | 0 | 6 | - | CP55940 | Surr | 3 | 5 | 2 | 3 | Gi/o | 4 | 3' | 1' | 4' | 2' | 37 | 100 | 18 | 43 | Efficacy | 0.02 | 0.06 | 0.01 | 0.02 | Gi1 | 37 | - | - | 100 | - | - | - | - | - | - | 18 | - | - | - | 43 | - | Efficacy | 0.02 | - | - | 0.06 | - | - | - | - | - | - | 0.01 | - | - | - | 0.02 | - | |
CNR1 | CB1 | ![]() |
Cannabinoid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | anandamide | Phys | 3 | 5 | 2 | 3 | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
CNR1 | CB1 | ![]() |
Cannabinoid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 5 | 2 | 3 | Gi/o | 2 | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CNR1 | CB1 | ![]() |
Cannabinoid | A | - | GproteinDb | merged data | - | - | - | - | - | 3 | 5 | 2 | 3 | Gi/o | 4 | 4' | 1' | 3' | 2' | 18 | 100 | 30 | 44 | - | - | - | - | - | Gi1 | 18 | - | - | 100 | 93 | - | - | 92 | 98 | 99 | 4 | 0 | 48 | 50 | 58 | 44 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CNR2 | CB2 | ![]() |
Cannabinoid | A | - | Bouvier | GEMTA | 3 | 12 | WIN55212-2 | Surr | 1 | 2 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 60 | 0 | log(Emax/EC50) | 0.0 | 8.9 | 5.4 | 0.0 | Gi1 | 0 | - | - | 100 | 98 | - | - | 93 | 91 | 97 | 0 | 0 | 0 | 60 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.9 | 8.7 | - | - | 8.3 | 8.1 | 8.7 | 0.0 | 0.0 | 0.0 | 5.4 | 0.0 | 0.0 | ||
CNR2 | CB2 | ![]() |
Cannabinoid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 2 | 1 | - | Gi/o | 2 | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CNR2 | CB2 | ![]() |
Cannabinoid | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 2 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 60 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 98 | - | - | 93 | 91 | 97 | 0 | 0 | 0 | 60 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
GPR18 | GPR18 | ![]() |
GPR18, GPR55 and GPR119 | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 1 | 1 | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | ||
GPR18 | GPR18 | ![]() |
GPR18, GPR55 and GPR119 | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR18 | GPR18 | ![]() |
GPR18, GPR55 and GPR119 | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
GPR55 | GPR55 | ![]() |
GPR18, GPR55 and GPR119 | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 1 | Gq/11 | 2 | - | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR55 | GPR55 | ![]() |
GPR18, GPR55 and GPR119 | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 1 | 1 | Gq/11 | 2 | - | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
GP119 | GPR119 | ![]() |
GPR18, GPR55 and GPR119 | A | - | Inoue | TGF𝛼 | 5 | 1 | GSK-1292263 | Surr | 1 | - | 1 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.3 | - | - | - | - | - | ||
GP119 | GPR119 | ![]() |
GPR18, GPR55 and GPR119 | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | - | 1 | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP119 | GPR119 | ![]() |
GPR18, GPR55 and GPR119 | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | 1 | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
PTAFR | PAF | ![]() |
Platelet-activating factor | A | - | Inoue | TGF𝛼 | 5 | 1 | PAF | Phys | - | 1 | 2 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.7 | - | - | - | - | - | ||
PTAFR | PAF | ![]() |
Platelet-activating factor | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 2 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PTAFR | PAF | ![]() |
Platelet-activating factor | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 2 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
PD2R | DP1 | ![]() |
Prostanoid | A | - | Inoue | NanoBiT-G | 1 | 8 | PGD2 | Phys | 3 | 1 | 2 | 1 | Gi/o | 4 | 2' | 1' | 3' | 4' | 96 | 100 | 92 | 90 | log(Emax/EC50) | 7.1 | 7.4 | 6.8 | 6.7 | Gi1 | - | 96 | - | 100 | 0 | 0 | - | - | 79 | - | 92 | - | - | - | 90 | 0 | log(Emax/EC50) | - | 7.1 | - | 7.4 | 0.0 | 0.0 | - | - | 5.9 | - | 6.8 | - | - | - | 6.7 | 0.0 | ||
PD2R | DP1 | ![]() |
Prostanoid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | PGD2 | Phys | 3 | 1 | 2 | 1 | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 22 | 0 | Activation rate (s-1) | 0.9 | 0.0 | 0.2 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 22 | - | 0 | Activation rate (s-1) | 0.9 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.2 | - | 0.0 | ||
PD2R | DP1 | ![]() |
Prostanoid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 1 | 2 | 1 | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
PD2R | DP1 | ![]() |
Prostanoid | A | - | GproteinDb | merged data | - | - | - | - | - | 3 | 1 | 2 | 1 | Gs | 4 | 1' | 3' | 2' | 4' | 98 | 50 | 57 | 45 | - | - | - | - | - | Gi1 | 100 | 96 | - | 100 | 0 | 0 | - | - | 40 | - | 46 | - | - | 22 | 90 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
PD2R2 | DP2 | ![]() |
Prostanoid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | PGD2 | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.6 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.6 | - | 0.0 | - | - | 0.0 | - | 0.0 | ||
PD2R2 | DP2 | ![]() |
Prostanoid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PD2R2 | DP2 | ![]() |
Prostanoid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - |