Class Receptor G protein coupling (merged sources) Guide To Pharmacology database Asuka Inoue et al., Cell 2019 Gs Gi/o Gq/11 G12/13
gnas2 gnal gnai1/gnai2 gnai3 gnao gnaz gnaq/gna11 gna14 gna15 gna12 gna13
Sum (Primary|Secondary|None|Total):
Class A 5HT1A 5-HT1A primary primary primary No coupling primary primary No coupling -1.38 -1.43 -0.63 -0.10 -0.48 -1.06 -0.96 0.0 -1.28 -1.32 -1.47
Class A 5HT1B 5-HT1B primary secondary primary No coupling primary secondary No coupling -1.83 -2.00 -0.38 0.0 -0.79 -0.63 -1.20 -0.62 -2.00 -1.24 -2.00
Class A 5HT1D 5-HT1D primary secondary primary No coupling primary secondary No coupling -1.78 -1.83 0.0 -0.04 -0.07 -0.24 -1.23 -0.51 -1.91 -1.62 -1.45
Class A 5HT1E 5-ht1E primary primary No coupling primary No coupling No coupling -2.00 -2.00 -0.43 0.0 -0.38 -0.72 -2.00 -2.00 -2.00 -2.00 -2.00
Class A 5HT1F 5-HT1F primary primary No coupling primary No coupling No coupling -2.00 -2.00 -0.42 0.0 -1.38 -2.00 -2.00 -2.00 -2.00 -2.00 -2.00
Class A 5HT2A 5-HT2A secondary primary secondary primary No coupling secondary primary No coupling -2.00 -2.00 -0.69 -0.22 -1.30 -0.49 -0.33 0.0 -1.15 -1.84 -1.79
Class A 5HT2B 5-HT2B secondary primary primary No coupling secondary primary No coupling -1.78 -1.91 -0.90 -0.72 -1.16 -0.20 0.0 -0.06 -1.81 -2.00 -1.87
Class A 5HT2C 5-HT2C primary primary secondary secondary primary No coupling primary secondary secondary -1.63 -1.77 -0.09 -0.51 -0.07 0.0 -0.35 -0.22 -0.13 -0.59 -0.62
Class A 5HT4R 5-HT4 primary primary secondary secondary primary secondary secondary primary secondary No coupling -0.60 -0.68 -0.02 0.0 -0.34 -0.17 -0.46 -0.25 -1.12 -1.00 -1.04
Class A 5HT5A 5-HT5A primary secondary primary secondary
Class A 5HT6R 5-HT6 primary secondary secondary secondary primary secondary primary secondary secondary secondary 0.0 -0.06 -0.98 -1.30 -0.90 -0.39 -0.54 -0.79 -1.54 -1.54 -0.39
Class A 5HT7R 5-HT7 primary secondary primary primary primary primary secondary primary primary -0.07 -0.07 -0.40 -0.29 -0.20 -0.17 -0.24 0.0 -0.38 -0.22 -0.06
Class A ACM1 M1 secondary primary primary No coupling secondary primary No coupling -1.30 -1.42 -0.60 -0.33 -1.22 -1.08 0.0 -0.17 -1.43 -1.97 -2.00
Class A ACM2 M2 secondary primary secondary secondary primary secondary No coupling primary No coupling No coupling -2.00 -2.00 -0.21 0.0 -0.65 -1.60 -1.76 -1.82 -2.00 -2.00 -2.00
Class A DRD2 D2 primary primary No coupling primary No coupling No coupling -2.00 -2.00 -0.21 0.0 -0.43 -0.59 -2.00 -2.00 -2.00 -2.00 -2.00
Class A ACM3 M3 secondary primary primary No coupling secondary primary No coupling -1.36 -1.38 -0.39 -0.21 -1.09 -1.00 0.0 -0.15 -0.73 -1.39 -1.95
Class A ACM4 M4 primary primary No coupling primary No coupling No coupling -1.92 -2.00 -0.22 0.0 -0.48 -1.28 -1.54 -1.48 -2.00 -2.00 -2.00
Class A ACM5 M5 secondary primary primary No coupling secondary primary No coupling -1.01 -1.06 -0.16 -0.12 -0.86 -0.78 0.0 -0.08 -0.21 -1.09 -1.86
Class A ADA1A α1A< primary secondary primary secondary
Class A ADA1B α1B< primary primary primary primary No coupling secondary No coupling 0.0 -0.30 -1.99 -2.00 -2.00 -2.00 -0.34 -0.20 -1.94 -2.00 -1.80
Class A ADA1D α1D< primary primary secondary primary primary No coupling primary secondary -0.03 -0.15 -1.44 -1.39 -1.86 -1.86 -0.17 0.0 -1.84 -1.91 -0.96
Class A ADA2A α2A< secondary primary secondary primary No coupling primary No coupling No coupling -2.00 -2.00 -0.32 0.0 -0.69 -0.05 -2.00 -2.00 -1.98 -1.96 -1.99
Class A ADA2B α2B< secondary primary secondary secondary primary No coupling primary No coupling secondary -1.86 -2.00 -0.20 0.0 -0.25 -0.51 -1.63 -1.21 -1.94 -0.69 -1.15
Class A ADA2C α2C< secondary primary secondary primary No coupling primary No coupling No coupling -2.00 -2.00 -0.13 -0.09 -0.62 0.0 -1.86 -1.78 -2.00 -1.89 -1.99
Class A ADRB1 β1 primary secondary primary primary secondary secondary No coupling primary No coupling -0.15 -0.35 -1.46 -1.49 -1.72 -1.76 -1.01 0.0 -2.00 -2.00 -1.83
Class A ADRB2 β2 primary secondary primary primary secondary primary No coupling primary No coupling 0.0 -0.24 -1.97 -1.62 -1.48 -1.85 -0.57 0.0 -2.00 -2.00 -2.00
Class A ADRB3 β3 primary secondary primary secondary primary No coupling No coupling No coupling 0.0 -0.31 -2.00 -2.00 -1.84 -1.99 -1.92 -1.75 -2.00 -2.00 -2.00
Class A DRD1 D1 primary secondary primary primary primary secondary primary No coupling 0.0 -0.15 -0.86 -0.88 -1.41 -0.35 -0.31 -0.09 -2.00 -1.70 -1.54
Class A DRD3 D3 primary primary No coupling primary No coupling No coupling -2.00 -2.00 -0.78 0.0 -0.71 -0.26 -2.00 -2.00 -2.00 -2.00 -2.00
Class A DRD4 D4 primary primary No coupling primary No coupling No coupling -2.00 -2.00 -0.43 0.0 -0.48 -0.39 -2.00 -2.00 -2.00 -2.00 -2.00
Class A DRD5 D5 primary secondary secondary secondary primary primary secondary secondary secondary -0.03 0.0 -0.46 -0.61 -0.42 -0.88 -0.24 -0.12 -1.85 -0.59 -0.58
Class A HRH1 H1 secondary primary primary primary secondary primary secondary No coupling -0.54 -0.53 0.0 -0.19 -0.55 -0.41 -0.19 -0.47 -0.56 -1.40 -2.00
Class A HRH2 H2 primary secondary primary secondary secondary primary primary secondary secondary secondary 0.0 -0.15 -0.92 -0.61 -0.57 -0.86 -0.93 -0.83 -2.00 -2.00 -0.83
Class A HRH3 H3 primary primary No coupling primary No coupling No coupling -2.00 -2.00 0.0 -0.17 -0.71 -1.48 -1.70 -1.35 -1.99 -1.88 -2.00
Class A HRH4 H4 primary primary No coupling primary No coupling No coupling -1.69 -1.85 0.0 -0.14 -1.19 -1.62 -1.76 -1.32 -1.05 -1.66 -2.00
Class A TAAR1 TA1 primary secondary primary secondary
Class A AGTR1 AT1 primary primary primary primary No coupling primary primary No coupling -1.45 -1.49 -0.45 0.0 -1.65 -2.00 -0.04 -0.16 0.0 -1.02 -1.28
Class A AGTR2 AT2 primary primary
Class A APJ apelin primary secondary primary No coupling primary secondary No coupling -2.00 -2.00 0.0 -0.05 -1.17 -1.54 -1.09 -0.83 -2.00 -1.87 -2.00
Class A NMBR BB1 secondary secondary primary secondary primary secondary secondary primary secondary -0.93 -0.86 -0.71 -0.45 -0.88 -0.68 0.0 -0.19 -2.00 -0.90 -0.43
Class A GRPR BB2 secondary secondary primary secondary primary secondary secondary primary secondary -0.58 -0.66 -0.73 -0.54 -0.79 -0.73 0.0 -0.19 -1.56 -0.33 -0.19
Class A BRS3 BB3 primary primary
Class A BKRB1 B1 secondary primary primary secondary primary primary secondary primary primary secondary -0.45 -0.57 0.0 -0.05 -0.09 -1.10 0.0 -0.12 -0.07 -0.55 -0.23
Class A BKRB2 B2 primary primary primary secondary primary primary primary No coupling primary primary secondary -1.86 -2.00 -0.30 0.0 -0.75 -1.72 -0.03 -0.06 -0.20 -0.90 -0.70
Class A CCKAR CCK1 secondary primary primary secondary secondary primary secondary primary primary secondary -0.59 -0.61 -0.20 -0.10 -0.86 -1.41 -0.27 0.0 -0.78 -0.66 -1.05
Class A GASR CCK2 secondary secondary primary secondary primary secondary secondary primary secondary -0.50 -0.53 -0.37 -0.16 -0.99 -1.36 -0.05 0.0 -0.92 -0.73 -0.84
Class A C3AR C3a
Class A C5AR1 C5a1 primary secondary primary secondary
Class A C5AR2 C5a2
Class A EDNRA ETA secondary primary primary primary primary secondary primary primary primary -0.61 -0.80 -0.02 -0.12 -0.59 -0.34 -0.12 0.0 -0.64 -0.03 -0.51
Class A EDNRB ETB primary primary primary primary primary primary primary secondary primary secondary primary -0.90 -0.98 0.0 -0.02 -0.58 -0.42 -0.65 -0.48 -0.41 -0.05 -0.48
Class A FPR1 FPR1 primary secondary primary No coupling primary secondary No coupling -2.00 -2.00 -0.92 0.0 -1.84 -2.00 -1.94 -0.77 -2.00 -2.00 -2.00
Class A FPR2 FPR2/ALX primary primary primary secondary No coupling secondary primary No coupling -2.00 -1.92 -1.02 -0.18 -1.30 -1.44 -1.41 0.0 -1.90 -1.73 -1.59
Class A FPR3 FPR3 primary primary
Class A GALR1 GAL1 primary primary No coupling primary No coupling No coupling -1.99 -1.90 -0.36 0.0 -0.83 -1.50 -1.44 -1.48 -1.94 -1.64 -1.87
Class A GALR2 GAL2 secondary primary secondary secondary primary secondary No coupling secondary primary secondary -2.00 -2.00 -0.86 -0.22 -1.07 -1.93 0.0 -0.34 -0.87 -0.32 -0.82
Class A GALR3 GAL3 primary secondary primary No coupling primary secondary No coupling -2.00 -2.00 -0.30 0.0 -0.11 -0.18 -1.84 -0.59 -1.87 -2.00 -2.00
Class A GHSR ghrelin secondary secondary primary secondary secondary primary secondary secondary secondary primary secondary -0.37 -0.52 -0.69 -0.34 -0.22 -0.48 -0.45 0.0 -0.12 -0.17 -0.20
Class A GNRHR GnRH1 secondary secondary primary secondary primary secondary secondary primary No coupling -0.12 -0.20 -0.98 -0.50 -1.44 -1.12 0.0 -0.22 -1.99 -1.97 -2.00
Class A KISSR kisspeptin primary primary No coupling No coupling primary No coupling -1.61 -1.69 -1.45 -1.02 -1.89 -2.00 0.0 -0.08 -2.00 -1.80 -1.99
Class A MCHR1 MCH1 primary primary primary primary primary primary secondary primary primary No coupling -0.96 -0.94 -0.50 0.0 -0.82 -1.87 -0.09 -1.54 -2.00 -1.56 -1.40
Class A MCHR2 MCH2 secondary primary primary secondary primary secondary primary primary secondary -0.82 -0.79 -0.66 -0.10 -1.40 -1.47 0.0 -0.74 -0.86 -0.91 -1.07
Class A MSHR MC1 primary primary primary secondary No coupling primary No coupling -0.69 -1.37 -1.40 -1.28 -1.48 -1.06 -0.51 0.0 -2.00 -2.00 -2.00
Class A ACTHR MC2 primary primary
Class A MC3R MC3 primary secondary secondary primary primary secondary secondary secondary primary -1.17 -0.70 -1.11 -0.49 -0.84 -0.37 -0.52 -0.19 -0.20 -0.08 -0.45
Class A MC4R MC4 primary secondary primary secondary primary secondary secondary primary secondary -0.64 -0.40 -0.74 -0.38 -1.45 -0.42 -0.38 0.0 -1.88 -0.88 -1.13
Class A MC5R MC5 primary secondary primary secondary primary secondary secondary primary secondary -0.81 -0.88 -0.88 -0.58 -1.72 -0.79 -0.68 0.0 -1.23 -0.70 -0.75
Class A MTLR motilin secondary primary primary primary primary No coupling secondary primary secondary -1.19 -1.25 -0.82 -0.40 -1.37 -1.30 0.0 -0.56 -1.65 -0.88 -1.16
Class A NMUR1 NMU1 primary primary No coupling No coupling primary No coupling -1.46 -1.40 -1.46 -1.06 -2.00 -1.97 0.0 -0.16 -2.00 -1.92 -1.87
Class A NMUR2 NMU2 primary primary secondary primary No coupling primary primary secondary -1.73 -1.77 -0.43 0.0 -0.99 -0.96 -0.05 -0.13 -0.26 -0.65 -1.62
Class A NPFF1 NPFF1 primary primary No coupling primary No coupling No coupling -2.00 -2.00 -0.66 0.0 -0.89 -0.77 -1.95 -2.00 -2.00 -2.00 -2.00
Class A NPFF2 NPFF2 primary primary No coupling primary No coupling No coupling -2.00 -2.00 -0.16 0.0 -0.28 -0.27 -2.00 -2.00 -2.00 -2.00 -2.00
Class A NPSR1 NPS secondary primary secondary primary
Class A NPBW1 NPBW1 primary primary No coupling primary No coupling No coupling -2.00 -2.00 -0.10 0.0 -1.43 -2.00 -2.00 -2.00 -2.00 -2.00 -2.00
Class A NPBW2 NPBW2 primary primary
Class A NPY1R Y1 primary primary
Class A CXCR1 CXCR1 primary secondary primary secondary
Class A NPY2R Y2 primary secondary primary secondary
Class A NPY4R Y4 primary secondary primary secondary
Class A NPY5R Y5 primary primary
Class A NPY6R y6
Class A NTR1 NTS1 secondary secondary primary secondary secondary primary
Class A NTR2 NTS2 primary primary
Class A OPRD δ primary secondary primary No coupling primary secondary No coupling -2.00 -2.00 -0.37 0.0 -1.24 -1.60 -1.90 -0.47 -1.93 -1.81 -2.00
Class A OPRK κ primary secondary primary secondary No coupling primary No coupling No coupling -2.00 -2.00 -0.27 0.0 -0.87 -0.72 -1.87 -1.28 -1.96 -1.65 -2.00
Class A OPRM μ primary secondary primary secondary No coupling primary No coupling No coupling -2.00 -2.00 -0.21 0.0 -0.91 -0.78 -2.00 -1.21 -2.00 -1.93 -2.00
Class A OPRX NOP primary secondary primary No coupling primary secondary No coupling -2.00 -2.00 -0.56 0.0 -0.85 -0.63 -2.00 -0.73 -2.00 -1.87 -2.00
Class A OX1R OX1 primary primary primary primary primary primary primary No coupling secondary primary primary -1.33 -1.30 -0.26 -0.33 -0.83 -0.39 -0.24 0.0 -0.06 -0.05 -0.16
Class A OX2R OX2 primary primary primary secondary primary primary primary No coupling secondary primary secondary -1.27 -1.26 -0.76 -0.48 -0.97 -0.74 0.0 0.0 -1.40 -1.05 -0.49
Class A QRFPR QRFP primary primary primary primary
Class A PRLHR PrRP secondary primary secondary No coupling secondary primary secondary -1.97 -1.87 -0.82 -0.43 -0.71 -2.00 0.0 -0.07 -2.00 -2.00 -0.83
Class A PAR1 PAR1 primary primary primary No coupling primary primary primary -2.00 -2.00 -0.02 -0.09 -0.35 -0.67 -0.20 -0.47 0.0 -0.02 -0.22
Class A PAR2 PAR2 secondary primary secondary primary secondary primary secondary primary -0.99 -1.09 0.0 -0.09 -0.32 -0.42 -0.12 -0.19 -0.24 -0.10 -0.14
Class A PAR3 PAR3 secondary secondary secondary primary secondary secondary secondary primary -0.58 -0.79 -0.49 -0.15 -0.75 -1.29 -1.36 -0.70 -0.25 0.0 -0.65
Class A PAR4 PAR4 secondary primary secondary primary secondary primary secondary primary -0.62 -0.65 -0.10 0.0 -0.43 -0.99 -0.11 -0.34 -1.17 -0.17 0.0
Class A RXFP1 RXFP1 primary primary primary primary
Class A RXFP2 RXFP2 primary primary primary primary
Class A RL3R1 RXFP3 primary primary
Class A RL3R2 RXFP4 primary primary
Class A SSR1 SST1 primary secondary primary No coupling primary No coupling secondary -2.00 -2.00 -0.30 0.0 -1.09 -1.81 -1.94 -1.52 -1.77 -0.76 -1.93
Class A SSR2 SST2 primary secondary primary No coupling primary secondary No coupling -2.00 -2.00 -0.77 0.0 -1.16 -1.59 -2.00 -0.81 -1.65 -2.00 -2.00
Class A SSR3 SST3 primary primary No coupling primary No coupling No coupling -2.00 -2.00 -0.25 0.0 -1.31 -1.64 -1.93 -1.47 -1.93 -2.00 -2.00
Class A SSR4 SST4 primary secondary primary No coupling primary No coupling secondary -2.00 -2.00 -0.47 0.0 -1.26 -1.82 -2.00 -1.39 -1.65 -0.90 -1.88
Class A SSR5 SST5 primary primary No coupling primary No coupling No coupling -2.00 -2.00 -0.47 0.0 -0.77 -1.02 -2.00 -1.21 -1.90 -1.71 -2.00
Class A NK1R NK1 primary secondary primary secondary primary primary secondary secondary primary secondary -0.56 -0.60 -0.38 -0.50 -0.68 -0.75 -0.06 0.0 -1.10 -0.63 -0.31
Class A NK2R NK2 primary secondary primary primary primary No coupling secondary primary No coupling -1.42 -1.41 -0.61 -0.54 -1.24 -1.28 0.0 -0.01 -1.57 -1.13 -1.24
Class A NK3R NK3 secondary secondary primary secondary primary secondary secondary primary secondary -0.67 -0.77 -0.55 -0.64 -1.30 -1.26 -0.02 0.0 -1.33 -0.87 -0.50
Class A CXCR2 CXCR2 primary primary
Class A TRFR TRH1 primary primary
Class A UR2R UT secondary primary primary secondary primary secondary primary secondary secondary -0.35 -0.39 0.0 -0.23 -0.25 -0.17 -0.30 -0.26 -0.88 -0.30 -1.00
Class A V1AR V1A secondary primary primary secondary No coupling primary No coupling -0.57 -0.65 -1.37 -1.41 -2.00 -1.98 0.0 -1.25 -2.00 -2.00 -2.00
Class A V1BR V1B secondary secondary primary primary secondary secondary primary No coupling -0.33 -0.40 -0.94 -0.85 -1.51 -1.54 0.0 -1.14 -1.99 -1.80 -1.99
Class A V2R V2 primary primary primary No coupling No coupling No coupling 0.0 -0.08 -2.00 -2.00 -2.00 -1.88 -2.00 -2.00 -2.00 -1.91 -2.00
Class A OXYR OT secondary secondary primary secondary primary secondary secondary primary No coupling -0.65 -0.71 -0.75 -0.75 -1.87 -1.83 0.0 -0.88 -2.00 -1.93 -2.00
Class A CML1 chemerin primary primary
Class A CCR1 CCR1 primary primary
Class A CCR2 CCR2 primary primary
Class A CCR3 CCR3 primary primary
Class A CCR4 CCR4 primary primary
Class A CCR5 CCR5 primary primary
Class A CCR6 CCR6 primary primary
Class A CCR7 CCR7 primary primary
Class A CCR8 CCR8 primary primary
Class A CCR9 CCR9 primary primary
Class A CCR10 CCR10 primary primary
Class A CXCR3 CXCR3 primary primary
Class A CXCR4 CXCR4 primary primary
Class A CXCR5 CXCR5 primary primary
Class A CXCR6 CXCR6 primary primary
Class A CX3C1 CX3C primary primary
Class A XCR1 XCR1 primary primary
Class A ACKR1 ACKR1
Class A ACKR2 ACKR2
Class A ACKR3 ACKR3
Class A ACKR4 ACKR4
Class A CCRL2 CCRL2
Class A FSHR FSH primary primary primary primary primary primary
Class A LSHR LH primary secondary primary secondary
Class A TSHR TSH primary secondary primary secondary
Class A PKR1 PKR1 secondary primary secondary primary
Class A PKR2 PKR2 secondary secondary primary secondary secondary primary
Class A FFAR1 FFA1 secondary secondary primary secondary secondary secondary primary secondary secondary primary secondary -0.34 -0.32 -0.41 -2.00 -0.35 -1.04 0.0 -2.00 -1.25 -0.91 -1.15
Class A FFAR2 FFA2 secondary secondary primary primary secondary primary secondary secondary primary primary -0.57 -0.63 -2.00 -1.34 -0.62 -1.63 -0.07 -2.00 -0.15 0.0 -0.06
Class A FFAR3 FFA3 primary secondary primary No coupling primary No coupling secondary -2.00 -2.00 0.0 -0.16 -1.05 -1.11 -2.00 -1.92 -1.93 -0.42 -1.04
Class A FFAR4 FFA4 secondary primary primary secondary primary secondary primary secondary secondary -0.47 -0.64 0.0 -0.08 -0.35 -0.38 -0.53 -0.39 -1.49 -0.66 -0.77
Class A GPR42 GPR42
Class A LT4R1 BLT1 primary primary primary primary No coupling primary secondary No coupling -1.04 -1.15 -0.44 0.0 -0.93 -1.25 -1.17 -0.74 -1.23 -1.00 -1.14
Class A LT4R2 BLT2 primary secondary primary secondary No coupling primary No coupling No coupling -2.00 -2.00 -0.49 0.0 -1.94 -2.00 -1.55 -1.73 -2.00 -1.52 -2.00
Class A CLTR1 CysLT1 secondary primary secondary primary No coupling secondary primary No coupling -1.29 -1.42 -0.94 -0.54 -1.36 -1.76 0.0 -0.20 -0.69 -1.94 -2.00
Class A CLTR2 CysLT2 secondary primary secondary primary No coupling secondary primary No coupling -2.00 -2.00 -1.46 -0.75 -1.63 -0.63 0.0 -0.12 -1.81 -1.95 -2.00
Class A OXER1 OXE primary primary
Class A LPAR1 LPA1 primary primary primary primary primary primary No coupling secondary primary primary -1.90 -2.00 -0.18 -0.12 -0.48 -2.00 -0.36 -0.02 0.0 -0.28 -0.09
Class A LPAR2 LPA2 secondary primary primary primary primary primary primary secondary secondary primary primary -0.43 -0.51 -0.37 -0.37 -0.35 -0.54 -0.01 -0.41 -0.09 0.0 -0.21
Class A LPAR3 LPA3 secondary primary primary secondary primary primary secondary primary secondary secondary -1.03 -0.90 -0.23 -0.07 -0.09 0.0 -0.46 -0.38 -0.59 -0.73 -0.46
Class A LPAR4 LPA4 primary primary primary primary primary primary primary primary primary secondary secondary secondary 0.0 -0.08 -0.19 -0.29 -0.16 -0.32 -0.67 -0.33 -0.27 -0.51 -0.22
Class A LPAR5 LPA5 primary primary primary primary primary No coupling primary No coupling secondary -2.00 -2.00 -0.06 -0.16 0.0 -0.11 -1.52 -1.34 -1.60 -0.64 -0.71
Class A LPAR6 LPA6 primary primary secondary primary primary primary primary No coupling secondary secondary primary -1.18 -1.54 -0.32 -0.12 -0.21 -0.69 -1.14 -0.72 -1.16 0.0 -0.01
Class A S1PR1 S1P1 primary primary No coupling primary No coupling No coupling -1.69 -1.99 -0.48 0.0 -0.89 -0.49 -1.75 -1.77 -1.86 -1.19 -1.59
Class A S1PR2 S1P2 primary secondary primary primary primary primary primary No coupling secondary secondary primary -1.77 -1.84 -0.63 -0.20 -0.41 -0.16 -0.85 -0.40 -1.09 0.0 -0.28
Class A S1PR3 S1P3 secondary primary primary primary primary primary primary secondary primary primary primary -0.94 -0.98 -0.09 0.0 -0.05 -0.24 -0.32 -0.24 -0.06 -0.01 -0.18
Class A S1PR4 S1P4 primary primary primary primary
Class A S1PR5 S1P5 primary primary primary primary No coupling primary No coupling No coupling -2.00 -2.00 -0.39 0.0 -1.95 -1.60 -1.99 -1.80 -1.66 -1.91 -1.39
Class A CNR1 CB1 secondary primary secondary primary secondary primary No coupling primary secondary primary -2.00 -2.00 -0.03 -0.12 0.0 -0.32 -1.68 -0.74 -1.68 -0.05 -0.24
Class A CNR2 CB2 secondary primary secondary primary No coupling primary No coupling No coupling -2.00 -2.00 0.0 -0.02 -0.25 -0.63 -2.00 -1.34 -2.00 -1.92 -2.00
Class A GPR18 GPR18 primary primary primary primary
Class A GPR55 GPR55 primary primary primary primary No coupling No coupling No coupling primary -2.00 -2.00 -2.00 -1.45 -1.94 -2.00 -1.98 -1.95 -1.99 -2.00 0.0
Class A GP119 GPR119 primary primary primary primary primary primary primary No coupling 0.0 -0.15 -1.00 -0.74 -0.53 -0.08 -0.21 -0.03 -1.77 -1.50 -1.41
Class A PTAFR PAF primary primary primary secondary primary primary primary primary primary secondary -0.08 -0.09 -0.14 -0.34 -0.02 -0.12 0.0 -0.38 -0.06 -0.46 -0.23
Class A PD2R DP1 primary primary primary No coupling No coupling No coupling 0.0 -0.16 -2.00 -2.00 -2.00 -2.00 -1.33 -1.88 -2.00 -1.98 -1.96
Class A PD2R2 DP2 primary primary
Class A PE2R1 EP1 secondary secondary primary secondary secondary primary secondary No coupling primary secondary -0.56 -0.67 -1.10 -1.66 -1.70 -1.88 0.0 -0.40 -1.69 -0.56 -1.04
Class A PE2R2 EP2 primary primary primary No coupling No coupling No coupling 0.0 -0.53 -2.00 -2.00 -2.00 -2.00 -1.49 -1.77 -2.00 -2.00 -2.00
Class A PE2R3 EP3 primary secondary primary primary secondary No coupling secondary No coupling primary -1.82 -1.92 -0.49 -0.76 -0.58 -0.86 -2.00 -1.36 -2.00 0.0 -1.23
Class A P2Y14 P2Y14 primary secondary primary No coupling primary secondary No coupling -2.00 -2.00 0.0 -0.30 -0.05 -0.14 -1.65 -0.78 -2.00 -2.00 -2.00
Class A PE2R4 EP4 primary secondary primary secondary primary secondary No coupling No coupling 0.0 -0.10 -0.32 -2.00 -2.00 -2.00 -1.71 -1.78 -2.00 -1.98 -1.82
Class A PF2R FP primary primary secondary primary primary No coupling primary No coupling -0.04 -0.16 -1.88 -1.45 -1.98 -1.96 0.0 -0.34 -1.46 -1.68 -1.02
Class A PI2R IP primary secondary secondary primary secondary secondary primary No coupling secondary No coupling 0.0 -0.25 -2.00 -2.00 -2.00 -2.00 -0.85 -1.94 -2.00 -1.98 -2.00
Class A TA2R TP secondary primary secondary primary No coupling secondary primary secondary -1.10 -1.26 -0.93 -1.72 -2.00 -2.00 0.0 -0.06 -2.00 -1.09 -0.44
Class A MTR1A MT1 primary secondary primary secondary No coupling primary No coupling No coupling -2.00 -2.00 -0.12 0.0 -0.41 -0.04 -2.00 -2.00 -2.00 -2.00 -2.00
Class A MTR1B MT2 primary primary No coupling primary No coupling No coupling -2.00 -2.00 0.0 0.0 -0.89 -0.29 -2.00 -2.00 -2.00 -2.00 -2.00
Class A AA1R A1 secondary primary secondary secondary primary secondary No coupling primary No coupling No coupling -1.99 -2.00 -0.48 -0.22 0.0 -0.09 -1.73 -1.33 -1.12 -1.68 -2.00
Class A AA2AR A2A primary primary primary primary secondary primary primary primary No coupling 0.0 -0.04 -0.26 -0.20 -0.01 -0.15 -0.22 -0.07 -2.00 -1.52 -1.77
Class A AA2BR A2B primary primary secondary primary secondary secondary primary secondary No coupling -0.13 -0.41 -0.24 -0.01 0.0 -0.48 -0.74 -0.14 -1.91 -1.45 -1.10
Class A AA3R A3 primary primary No coupling primary No coupling No coupling -2.00 -2.00 -0.16 0.0 -1.51 -1.99 -2.00 -2.00 -2.00 -2.00 -2.00
Class A P2RY1 P2Y1 primary primary primary secondary secondary primary primary primary secondary secondary -0.01 0.0 -0.21 -1.51 -0.04 -0.13 -2.00 -2.00 -0.17 -0.14 -0.29
Class A P2RY2 P2Y2 secondary secondary primary primary secondary primary secondary secondary No coupling primary primary -0.45 -0.26 -2.00 -2.00 -2.00 -1.13 -2.00 -1.84 0.0 -0.12 -0.09
Class A P2RY4 P2Y4 primary primary secondary primary No coupling primary secondary secondary -1.34 -1.62 0.0 -0.22 -0.11 -0.69 -2.00 -2.00 -0.89 -1.50 -0.45
Class A P2RY6 P2Y6 primary secondary primary primary primary secondary primary secondary secondary primary 0.0 -0.09 -1.23 -2.00 -0.90 -0.16 -2.00 -2.00 -0.15 -0.01 -0.18
Class A P2Y11 P2Y11 secondary primary primary primary secondary primary secondary primary secondary primary -0.27 -0.33 -0.07 0.0 -0.20 -0.55 -0.17 -0.35 -0.82 -0.11 -0.06
Class A P2Y12 P2Y12 primary No coupling primary No coupling No coupling -1.93 -1.94 -0.16 0.0 -0.10 -0.75 -1.39 -1.06 -2.00 -1.08 -1.23
Class A P2Y13 P2Y13 primary primary secondary primary No coupling secondary primary secondary -1.99 -2.00 -1.27 -1.38 -0.80 -1.49 -0.04 0.0 -0.71 -0.42 -0.45
Class A GPBAR GPBA primary primary
Class A GPER1 GPER secondary primary secondary primary
Class A HCAR1 HCA1 primary primary
Class A HCAR2 HCA2 primary primary
Class A HCAR3 HCA3 primary primary
Class A OXGR1 oxoglutarate secondary secondary primary secondary primary secondary secondary primary secondary -0.66 -0.82 -0.44 -0.34 -0.48 -0.45 0.0 -0.19 -2.00 -0.92 -1.53
Class A SUCR1 succinate primary secondary primary secondary
Class A OPSD Rhodopsin
Class A OPN4 Melanopsin primary primary primary primary
Class A OPN3 Opsin-3
Class A OPN5 Opsin-5 primary primary
Class A OPSB Short-wave-sens
Class A OPSG Medium-wave-sen
Class A OPSR Long-wave-sensi
Class A GPR1 GPR1
Class A GPR3 GPR3 primary primary
Class A GPR4 GPR4 primary primary primary primary primary primary primary primary
Class A GPR6 GPR6 primary primary primary primary
Class A GPR12 GPR12 primary primary primary primary
Class A GPR15 GPR15
Class A GPR17 GPR17 primary secondary primary secondary No coupling primary secondary No coupling -2.00 -2.00 0.0 -0.09 -0.92 -1.89 -0.23 -1.37 -2.00 -1.61 -1.80
Class A GPR19 GPR19
Class A GPR20 GPR20 primary primary
Class A GPR21 GPR21
Class A GPR22 GPR22 primary primary
Class A GPR25 GPR25
Class A GPR26 GPR26 primary primary
Class A GPR27 GPR27 primary primary
Class A GPR31 GPR31 primary primary
Class A GPR32 GPR32
Class A GPR33 GPR33 primary primary
Class A GPR34 GPR34 primary primary No coupling primary No coupling No coupling -1.32 -2.00 0.0 -0.33 -0.17 -1.31 -2.00 -2.00 -1.83 -1.52 -2.00
Class A GPR35 GPR35 primary secondary No coupling primary No coupling secondary -2.00 -2.00 -0.22 -0.17 0.0 -0.85 -2.00 -2.00 -2.00 -0.13 -0.34
Class A GPR37 GPR37 primary primary
Class A ETBR2 GPR37L1 primary primary
Class A GPR39 GPR39 secondary primary secondary secondary primary secondary
Class A GPR45 GPR45
Class A MTR1L GPR50
Class A GPR52 GPR52
Class A GPR61 GPR61
Class A GPR62 GPR62
Class A GPR63 GPR63
Class A PSYR GPR65 primary primary
Class A OGR1 GPR68 primary primary primary primary
Class A GPR75 GPR75 primary primary
Class A GPR78 GPR78 primary primary
Class A GPR82 GPR82
Class A GPR83 GPR83
Class A GPR84 GPR84 primary primary No coupling primary No coupling No coupling -2.00 -1.81 -0.52 0.0 -0.31 -0.88 -1.84 -1.69 -1.47 -1.46 -1.81
Class A GPR85 GPR85
Class A GPR87 GPR87
Class A GPR88 GPR88
Class A GP101 GPR101 primary primary
Class A GP132 GPR132 primary secondary primary secondary primary secondary primary secondary -0.01 -0.21 -1.83 -0.81 -0.68 -0.55 0.0 -0.13 -0.38 -0.73 -0.71
Class A GP135 GPR135
Class A GP139 GPR139 primary primary
Class A GP141 GPR141
Class A GP142 GPR142
Class A GP146 GPR146
Class A GP148 GPR148
Class A GP149 GPR149
Class A GP150 GPR150
Class A GP151 GPR151
Class A GP152 GPR152
Class A GP153 GPR153
Class A GP160 GPR160
Class A GP161 GPR161
Class A GP162 GPR162
Class A GP171 GPR171
Class A GP173 GPR173
Class A GP174 GPR174 primary secondary primary No coupling No coupling secondary 0.0 -0.48 -1.84 -1.69 -1.92 -1.87 -1.74 -2.00 -2.00 -2.00 -0.63
Class A GP176 GPR176
Class A GP182 GPR182
Class A GP183 GPR183 primary secondary primary No coupling primary No coupling secondary -2.00 -2.00 -0.14 0.0 -0.16 -0.87 -1.26 -1.24 -1.12 -0.91 -2.00
Class A LGR4 LGR4
Class A LGR5 LGR5
Class A TAAR8 TAAR8
Class A LGR6 LGR6
Class A MAS MAS1 primary primary primary primary
Class A MAS1L MAS1L
Class A MRGRD MRGPRD primary primary primary primary
Class A MRGRE MRGPRE
Class A MRGRF MRGPRF
Class A MRGRG MRGPRG
Class A MRGX1 MRGPRX1 primary secondary primary primary primary primary secondary secondary primary -0.02 0.0 -0.53 -0.47 -0.19 -0.36 -0.20 -0.49 -0.18 -0.07 -0.16
Class A MRGX2 MRGPRX2 secondary primary primary secondary primary primary secondary primary primary secondary -0.24 -0.22 0.0 -0.06 -0.13 -0.47 -0.10 -0.07 -0.59 -0.36 -0.67
Class A MRGX3 MRGPRX3 primary primary
Class A MRGX4 MRGPRX4 primary primary
Class A P2RY8 P2RY8
Class A P2Y10 P2RY10 secondary secondary primary No coupling secondary secondary primary -2.00 -2.00 -0.53 -0.38 -0.91 -0.68 -1.17 -0.53 -2.00 -0.28 0.0
Class A TAAR2 TAAR2
Class A TAAR3 TAAR3
Class A TAAR5 TAAR5
Class A TAAR6 TAAR6
Class A TAAR9 TAAR9
Class B1 CALCR CT primary secondary primary secondary
Class B1 CALRL calcitonin-like
Class B1 CRFR1 CRF1 primary secondary primary secondary
Class B1 CRFR2 CRF2 primary secondary primary secondary
Class B1 GHRHR GHRH primary primary
Class B1 GIPR GIP primary primary primary No coupling No coupling No coupling 0.0 -0.11 -1.70 -1.57 -1.95 -1.84 -1.49 -1.09 -2.00 -1.66 -1.92
Class B1 GLP1R GLP-1 primary primary
Class B1 GLP2R GLP-2
Class B1 GLR glucagon primary primary
Class B1 SCTR secretin
Class B1 PTH1R PTH1 primary secondary primary secondary primary No coupling secondary No coupling 0.0 -0.20 -1.87 -1.89 -2.00 -1.74 -0.93 -1.02 -1.83 -1.72 -2.00
Class B1 PTH2R PTH2 primary secondary secondary secondary primary secondary secondary secondary 0.0 -0.14 -0.76 -0.73 -1.05 -0.91 -0.19 -0.16 -0.22 -0.68 -0.89
Class B1 PACR PAC1 primary primary primary primary primary No coupling primary No coupling -0.05 -0.07 -1.43 -1.39 -1.43 -1.66 0.0 -0.53 -1.96 -1.99 -1.77
Class B1 VIPR1 VPAC1 primary secondary secondary primary secondary secondary
Class B1 VIPR2 VPAC2 primary primary
Class B2 AGRL1 ADGRL1 primary primary
Class B2 AGRL2 ADGRL2
Class B2 AGRL3 ADGRL3
Class B2 AGRL4 ADGRL4
Class B2 AGRE1 ADGRE1
Taste 2 TA2R9 TAS2R9
Class B2 AGRE2 ADGRE2 primary primary
Class B2 AGRE3 ADGRE3
Class B2 AGRE4 ADGRE4P
Class B2 CD97 ADGRE5 primary primary
Class B2 AGRA1 ADGRA1
Class B2 AGRA2 ADGRA2
Class B2 AGRA3 ADGRA3
Class B2 CELR1 CELSR1
Class B2 CELR2 CELSR2
Class B2 CELR3 CELSR3
Class B2 AGRD1 ADGRD1 primary primary
Class B2 AGRD2 ADGRD2
Class B2 AGRF1 ADGRF1
Class B2 AGRF2 ADGRF2
Class B2 AGRF3 ADGRF3
Class B2 AGRF4 ADGRF4
Class B2 AGRF5 ADGRF5
Class B2 BAI1 ADGRB1
Class B2 AGRB2 ADGRB2
Class B2 AGRB3 ADGRB3
Class B2 AGRG1 ADGRG1 primary primary primary primary
Class B2 AGRG2 ADGRG2 secondary secondary
Class B2 AGRG3 ADGRG3 primary primary
Class B2 AGRG4 ADGRG4
Class B2 AGRG5 ADGRG5
Class B2 AGRG6 ADGRG6
Class B2 AGRG7 ADGRG7
Class B2 GPR98 ADGRV1
Class C CASR CaS primary primary primary primary primary primary
Class C GABR1 GABAB1
Class C GABR2 GABAB2
Class C GRM1 mGlu1 secondary secondary primary secondary secondary primary
Class C GRM2 mGlu2 primary primary
Class C GRM3 mGlu3 primary primary
Taste 2 T2R10 TAS2R10
Class C GRM4 mGlu4 primary primary
Class C GRM5 mGlu5 secondary secondary primary secondary secondary primary
Class C GRM6 mGlu6 primary primary
Class C GRM7 mGlu7 primary primary
Class C GRM8 mGlu8 primary primary
Class C TS1R1 TAS1R1
Class C TS1R2 TAS1R2
Class F FZD3 FZD3 primary primary
Class C TS1R3 TAS1R3
Class C GP156 GPR156
Class C GP158 GPR158
Class C GP179 GPR179
Class C RAI3 GPRC5A
Class C GPC5B GPRC5B
Class C GPC5C GPRC5C
Class C GPC5D GPRC5D
Class C GPC6A GPRC6 primary primary
Class F FZD1 FZD1 secondary secondary secondary secondary
Class F FZD2 FZD2 primary primary
Taste 2 TA2R8 TAS2R8
Class F FZD4 FZD4 primary primary
Class F FZD5 FZD5
Class F FZD6 FZD6 primary primary primary primary
Class F FZD7 FZD7 primary primary primary primary
Class F FZD8 FZD8
Class F FZD9 FZD9 primary primary
Class F FZD10 FZD10 secondary secondary
Class F SMO SMO primary primary primary primary
Taste 2 TA2R1 TAS2R1
Taste 2 TA2R3 TAS2R3
Taste 2 TA2R4 TAS2R4
Taste 2 TA2R5 TAS2R5
Taste 2 TA2R7 TAS2R7
Taste 2 T2R13 TAS2R13
Taste 2 T2R14 TAS2R14
Taste 2 T2R16 TAS2R16
Taste 2 T2R19 TAS2R19
Taste 2 T2R20 TAS2R20
Taste 2 T2R30 TAS2R30
Taste 2 T2R31 TAS2R31
Taste 2 T2R38 TAS2R38
Taste 2 T2R39 TAS2R39
Taste 2 T2R40 TAS2R40
Taste 2 T2R41 TAS2R41
Taste 2 T2R42 TAS2R42
Taste 2 T2R43 TAS2R43
Taste 2 T2R45 TAS2R45
Taste 2 T2R46 TAS2R46
Taste 2 T2R50 TAS2R50
Taste 2 T2R60 TAS2R60
Other GPCRs GP107 GPR107
Other GPCRs G137A GPR137
Other GPCRs O51E1 OR51E1
Other GPCRs TPRA1 TPRA1
Other GPCRs GP143 GPR143
Other GPCRs GP157 GPR157