pirenzepine


SMILES CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2
InChIKey RMHMFHUVIITRHF-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 351.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations M1 M2 M3

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 6.48 7.13 7.46 ChEMBL
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 6.62 6.87 7.55 ChEMBL
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 4.74 6.22 6.92 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 7.54 8.14 8.28 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.9 7.18 7.45 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.98 7.43 7.86 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 6.8 7.06 7.32 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKd 4.3 4.3 4.3 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.28 6.55 6.76 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.6 7.86 8.55 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKd 7.7 7.7 7.7 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.0 6.25 6.7 PDSP Ki database
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 6.1 6.35 6.66 PDSP Ki database
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 6.33 6.9 7.46 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.48 7.92 8.2 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 5.0 6.63 7.45 PDSP Ki database
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 5.0 7.64 8.19 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.2 7.37 7.55 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.11 8.11 8.11 Drug Central
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.6 7.95 8.3 Guide to Pharmacology
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 5.3 6.35 7.4 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.17 8.17 8.17 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.0 6.35 6.7 Guide to Pharmacology
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.18 8.18 8.18 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 6.66 6.8 6.9 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 6.5 6.65 6.8 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.15 8.15 8.15 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.0 7.7 7.6 Guide to Pharmacology
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.18 8.18 8.18 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.8 6.95 7.1 Guide to Pharmacology
M1 ACM1 Fruit fly Acetylcholine (muscarinic) A pKi 8.19 8.19 8.19 Drug Central
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 8.19 8.19 8.19 Drug Central
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 7.1 7.1 7.1 Guide to Pharmacology
M4 ACM4 Mouse Acetylcholine (muscarinic) A pKi 6.4 6.4 6.4 PDSP Ki database
M4 ACM4 Chicken Acetylcholine (muscarinic) A pKi 7.6 7.6 7.6 PDSP Ki database
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 8.16 8.16 8.16 Drug Central
M5 ACM5 Rat Acetylcholine (muscarinic) A pKi 6.88 6.88 6.88 PDSP Ki database
M5 ACM5 Rat Acetylcholine (muscarinic) A pKi 7.1 7.1 7.1 Guide to Pharmacology
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 8.08 8.08 8.08 Drug Central
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 7.8 7.85 7.9 Guide to Pharmacology
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 8.12 8.12 8.12 Drug Central
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 6.14 6.61 7.09 PDSP Ki database
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 6.7 6.7 6.7 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M3 ACM3 Rat Acetylcholine (muscarinic) A pIC50 6.22 6.37 6.52 ChEMBL
M2 ACM2 Rat Acetylcholine (muscarinic) A pIC50 5.92 6.06 6.16 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pIC50 6.92 7.67 8.42 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 6.9 6.95 7.0 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pIC50 6.47 6.47 6.47 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pIC50 5.98 6.88 8.94 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pIC50 6.02 6.02 6.02 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 6.01 6.01 6.01 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 6.92 7.68 8.83 ChEMBL
A3 AA3R Human Adenosine A pIC50 8.12 8.12 8.12 Drug Central
TAS2R9 TA2R9 Human Taste 2 T pEC50 2.74 2.74 2.74 Guide to Pharmacology