GPCRdb

GPCRdb offers:

  • Reference data
  • Analysis tools
  • Visualization
  • Experiment design
  • Data deposition
  • References


G protein-coupled receptors (GPCRs) are cell-surface receptors mediating the responses of 2/3rds of human hormones1 and 1/3rd of drugs2. Each GPCR can bind several transducers, G proteins, GPCR kinases (GRKs) and arrestins leading to distinct intracellular signaling networks and functional outcomes.

Data

  • 805 Human proteins
  • 42,021 Species orthologs
  • 3,019 Generic residues
  • 1,716 GPCR structures
  • 880 Refined structures
  • 1,601 GPCR structure models
  • 634 Physiological ligand-GPCR structure models
  • 546 Drugs
  • 173 Compounds in trial
  • 121 Drug targets
  • 683 Disease indications
  • 222,036 Ligands
  • 527 Physiological ligands
  • 499,650 Ligand bioactivities
  • 35,588 Ligand site mutations
  • 66,281 Ligand interactions

Latest release

March 20, 2025
  • Complete redesign of the Drug section
  • New improved and curated Drug data (Nature Reviews Drug Discovery, 2025)
  • Dedicated sections for agents/drugs, indications and drug targets
  • Overview of the drugged GPCRome
  • New structures
  • Minor bug and performance fixes

All releases

Publications

Latest GPCRdb article

GPCRdb in 2025: adding odorant receptors, data mapper, structure similarity search and models of physiological ligand complexes.
Nucleic Acids Research, 2024

Structure analysis platform

An online GPCR structure analysis platform.
Nature Structural & Molecular Biology, 2021

Drug resource

GPCR drug discovery: new agents, targets and indications.
Nature Reviews Drug Discovery, 2025

Generic residue numbers

Generic GPCR residue numbers - aligning topology maps while minding the gaps.
Trends in pharmacological sciences, 2015

Related resources

GPCRdb, GproteinDb, ArrestinDb and Biased Signaling Atlas cover related aspects of signal transduction while serving dedicated research communities and use cases.

External GPCR sites