GPCRdb contains reference data, interactive visualisation and experiment design tools for G protein-coupled receptors (GPCRs). GPCRdb curates sequence alignments, structures and receptor mutations from literature. Interactive diagrams visualise receptor residues (e.g. snakeplot and helix box plot) and relationships (e.g phylogenetic trees). See the GPCRdb graphical overview, video, articles or documentation.

GPCRdb is developed by the David Gloriam group, integrates data from the large GPCR community and maintains an active collaboration with the Guide To Pharmacology (IUPHAR), GPCRmd and ERNEST. If you use the GPCRdb, please remember to cite us.

GPCRdb statistics

  • Proteins: 28,014
  • Human proteins: 423 (all non-olfactory)
  • Species: 4,621
  • Exp. structures: 486
  • Refined structures: 376
  • GPCR structure models: 974
  • GPCR-G protein structure models: 2,163
  • Ligands: 198,602
  • Mutants: 34,650
  • Ligand interactions: 24,992
GPCRdb had 37,858 different users since this date last year and 3,860 users in the last 30 days (Google Analytics).

Latest release

Oct. 8, 2020 Sept. 3, 2020
  • Updated GPCR annotated structures and it's encompassing browser and accordingly updated statistics.
  • Updated GPCR homology and refined structure models.
  • Updated GPCR-G protein complex structure models.
  • Updated ligand database.
  • New and faster phylogenetic tree tool.
  • New easy citation tool.
  • New join us tool.
  • Updated menu layout.