Alignments and Trees
Segment and residue customized sequence alignments and phylogenetic trees.
Structure Determination Resource
Construct design tool and suggested thermostabilizing mutations.
Homology Models
Multiple template homology models for the whole GPCRome.
Residue Plots
Customizable helix and snake plots for GPCR's, G-proteins and B-arrestins.
GPCRdb contains reference data, interactive visualisation and experiment design tools for G protein-coupled receptors (GPCRs). GPCRdb curates sequence alignments, structures and receptor mutations from literature. Interactive diagrams visualise receptor residues (e.g. snakeplot and helix box plot) and relationships (e.g phylogenetic trees). See the GPCRdb graphical overview, video, articles or documentation.
GproteinDb and ArrestinDb will be published as separate web resources.
GPCRdb is developed by the David Gloriam group, integrates data from the large GPCR community and maintains an active collaboration with the Guide To Pharmacology (IUPHAR), GPCRmd and ERNEST. If you use the GPCRdb, please remember to cite us.
GPCRdb statistics
- 424 Human proteins
- 43,093 Species orthologs
- 69,605 Genetic variants
- 1,789 Drugs
- 199,331 Ligands
- 34,598 Ligand site mutations
- 29,908 Ligand interactions
- Experimental structures
- 597 GPCRs
- 261 G proteins
- Structure models
- 1,002 GPCRs
- 3,069 GPCR-G protein complexes
- 530 Refined GPCR structures
Latest release
Sept. 10, 2021- Official release of the research hub: GPCRdb, GproteinDb, and ArrestinDb.
- Extension of the G protein and Arrestin couplings with new data and new functionalities.
- Updated documentation.
- Updated GPCR and G protein structures.
- Updated GPCR homology and refined structure models.
- Minor bug and performance fixes.