Alignments and Trees
Segment and residue customized sequence alignments and phylogenetic trees.
Structure Determination Resource
Construct design tool and suggested thermostabilizing mutations.
Homology Models
Multiple template homology models for the whole GPCRome.
Residue Plots
Customizable helix and snake plots for GPCR's, G-proteins and B-arrestins.
GPCRdb contains reference data, interactive visualisation and experiment design tools for G protein-coupled receptors (GPCRs). GPCRdb curates sequence alignments, structures and receptor mutations from literature. Interactive diagrams visualise receptor residues (e.g. snakeplot and helix box plot) and relationships (e.g phylogenetic trees). See the GPCRdb graphical overview, video, articles or documentation.
GPCRdb is developed by the David Gloriam group, integrates data from the large GPCR community and maintains an active collaboration with the Guide To Pharmacology (IUPHAR), GPCRmd and ERNEST. If you use the GPCRdb, please remember to cite us.
GPCRdb statistics
- Proteins: 28,015
- Human proteins: 423 (all non-olfactory)
- Species: 4,622
- Exp. structures: 488
- Refined structures: 391
- GPCR structure models: 969
- GPCR-G protein structure models: 2,163
- Ligands: 198,602
- Mutants: 34,652
- Ligand interactions: 25,087
Latest release
Nov. 4, 2020- New Isoforms resource accompanying the publication of this Nature article.
- Updated GPCR structures.
- Updated GPCR homology and refined structure models.
- Minor bug and performance fixes.