GPCRdb
G protein-coupled receptors (GPCRs) are cell-surface receptors mediating the responses of 2/3rds of human hormones1 and 1/3rd of
drugs2.
Each GPCR can bind several transducers, G proteins, GPCR kinases (GRKs) and arrestins
leading to distinct intracellular signaling networks and functional outcomes.
Data
- 805 Human proteins
- 42,026 Species orthologs
- 3,013 Generic residues
- 1,610 GPCR structures
- 857 Refined structures
- 1,601 GPCR structure models
- 625 Physiological ligand-GPCR structure models
- 968 Drugs
- 175 Drug targets
- 405 Disease indications
- 219,361 Ligands
- 527 Physiological ligands
- 494,390 Ligand bioactivities
- 36,138 Ligand site mutations
- 63,300 Ligand interactions
Publications
GPCRdb in 2025: adding odorant receptors, data mapper, structure similarity search and models of physiological ligand complexes.
Nucleic Acids Research, 2024
An online GPCR structure analysis platform.
Nature Structural & Molecular Biology, 2021
Trends in GPCR drug discovery: new agents, targets and indications.
Nature Reviews Drug Discovery, 2017
Generic GPCR residue numbers - aligning topology maps while minding the gaps.
Trends in pharmacological sciences, 2015