GPCRdb contains reference data, interactive visualisation and experiment design tools for G protein-coupled receptors (GPCRs). GPCRdb curates sequence alignments, structures and receptor mutations from literature. Interactive diagrams visualise receptor residues (e.g. snakeplot and helix box plot) and relationships (e.g phylogenetic trees). See the GPCRdb graphical overview, video, articles or documentation.

GproteinDb has been, and ArrestinDb will be, published as separate web resources.

GPCRdb is developed by the David Gloriam group, integrates data from the large GPCR community and maintains an active collaboration with the Guide To Pharmacology (IUPHAR), GPCRmd and ERNEST. If you use the GPCRdb, please remember to cite us.

GPCRdb statistics

  • 424 Human proteins
  • 43,107 Species orthologs
  • 69,605 Genetic variants
  • 1,789 Drugs
  • 199,382 Ligands
  • 34,717 Ligand site mutations
  • 31,474 Ligand interactions
  • Experimental structures
  • 637 GPCRs
  • 306 G proteins
  • Structure models
  • 991 GPCRs
  • 3,069 GPCR-G protein complexes
  • 554 Refined GPCR structures
GPCRdb, GproteinDb, and ArrestinDb had 50,440 different users since this date last year and 5,269 users in the last 30 days (Google Analytics).

Latest release

Dec. 23, 2021
  • Updated GPCR and G protein structures.
  • Minor bug and performance fixes.