GPCRdb offers:

G protein-coupled receptors (GPCRs) are cell-surface receptors mediating the responses of 2/3rds of human hormones1 and 1/3rd of drugs2. Each GPCR can bind several transducers, G proteins, GPCR kinases (GRKs) and arrestins leading to distinct intracellular signaling networks and functional outcomes.


  • 423 Human proteins
  • 40,422 Species orthologs
  • 69,580 Genetic variants
  • 968 Drugs
  • 175 Drug targets
  • 405 Disease indications
  • 217,560 Ligands
  • 527 Endogenous ligands
  • 488,534 Ligand bioactivities
  • 36,127 Ligand site mutations
  • 45,112 Ligand interactions
  • 1,102 GPCRs structures
  • 844 GPCRs structure models
  • 2,954 Generic residues
  • 488 Refined structures

Latest release

Sept. 22, 2023
  • New AlphaFold2-Multimer GPCR - G protein complex models
  • Coupling data added to complex models table
  • New refined complex structures
  • New refined complex structures
  • Updated interface interaction matrix with refined structures and AlphaFold2-Multimer models
  • New visualisation modes for GPCR - G protein interactions (biflare plot, matrix, 3D view)
  • Coupling interactions between residues with no generic residue number added
  • Receptor sequences updated to latest UniProt canonical sequence
  • Gα segment names changed to include domain annotation (e.g. from H5 to G.H5)
  • API calls added for G protein data
  • New structures
  • Minor bug and performance fixes

All releases


GPCRdb in 2023: State-specific structure models using AlphaFold2 and expansion of ligand resources.
Pándy-Szekeres, G., Caroli, J., Mamyrbekov, A., Kermani, A.A., Keserű, G.M., Kooistra, A.J. and Gloriam, D.E.
Nucleic Acids Research, 2023

GPCRdb in 2021: integrating GPCR sequence, structure and function.
Kooistra AJ, Mordalski S, Pandy-Szekeres G, Esguerra M, Mamyrbekov A, Munk C, Keseru GM, Gloriam DE
Nucleic acids research, 2021, 49:D335-D343

Structure of the class D GPCR Ste2 dimer coupled to two G proteins.
Velazhahan V, Ma N, Pandy-Szekeres G, Kooistra AJ, Lee Y, Gloriam DE, Vaidehi N, Tate CG
Nature, 2021, 589:148-153

An online GPCR structure analysis platform.
Kooistra AJ, Munk C, Hauser AS, Gloriam DE
Nature structural & molecular biology, 2021, 28:875-878

Combinatorial expression of GPCR isoforms affects signalling and drug responses.
Marti-Solano M, Crilly SE, Malinverni D, Munk C, Harris M, Pearce A, Quon T, Mackenzie AE, Wang X, Peng J, Tobin AB, Ladds G, Milligan G, Gloriam DE, Puthenveedu MA, Babu MM
Nature, 2020, 587:650-656

An online resource for GPCR structure determination and analysis.
Munk C, Mutt E, Isberg V, Nikolajsen LF, Bibbe JM, Flock T, Hanson MA, Stevens RC, Deupi X, Gloriam DE
Nature methods, 2019, 16:151-162

Related resources

GPCRdb, GproteinDb, ArrestinDb and Biased Signaling Atlas cover related aspects of signal transduction while serving dedicated research communities and use cases.

External GPCR sites