New state-specific structure models
Models and refined structures using AlphaFold2.
New ligand resources
Endogenous ligands and tool compounds.
New structure analysis resource
Structure comparison tool and similarity trees.
Alignments and Trees
Customized sequence alignments and phylogenetic trees .
GPCRdb
G protein-coupled receptors (GPCRs) are cell-surface receptors mediating the responses of 2/3rds of human hormones1 and 1/3rd of
drugs2.
Each GPCR can bind several transducers, G proteins, GPCR kinases (GRKs) and arrestins
leading to distinct intracellular signaling networks and functional outcomes.
Data
- 425 Human proteins
- 40,425 Species orthologs
- 69,580 Genetic variants
- 968 Drugs
- 175 Drug targets
- 405 Disease indications
- 219,278 Ligands
- 527 Endogenous ligands
- 494,325 Ligand bioactivities
- 36,127 Ligand site mutations
- 52,636 Ligand interactions
- 1,296 GPCRs structures
- 842 GPCRs structure models
- 2,927 Generic residues
- 743 Refined structures
Publications
GPCRdb in 2023: State-specific structure models using AlphaFold2 and expansion of ligand resources.
Pándy-Szekeres, G., Caroli, J., Mamyrbekov, A., Kermani, A.A., Keserű, G.M., Kooistra, A.J. and Gloriam, D.E.
Nucleic Acids Research, 2023
GPCRdb in 2021: integrating GPCR sequence, structure and function.
Kooistra AJ, Mordalski S, Pandy-Szekeres G, Esguerra M, Mamyrbekov A, Munk C, Keseru GM, Gloriam DE
Nucleic acids research, 2021, 49:D335-D343
Structure of the class D GPCR Ste2 dimer coupled to two G proteins.
Velazhahan V, Ma N, Pandy-Szekeres G, Kooistra AJ, Lee Y, Gloriam DE, Vaidehi N, Tate CG
Nature, 2021, 589:148-153
An online GPCR structure analysis platform.
Kooistra AJ, Munk C, Hauser AS, Gloriam DE
Nature structural & molecular biology, 2021, 28:875-878
Combinatorial expression of GPCR isoforms affects signalling and drug responses.
Marti-Solano M, Crilly SE, Malinverni D, Munk C, Harris M, Pearce A, Quon T, Mackenzie AE, Wang X, Peng J, Tobin AB, Ladds G, Milligan G, Gloriam DE, Puthenveedu MA, Babu MM
Nature, 2020, 587:650-656
An online resource for GPCR structure determination and analysis.
Munk C, Mutt E, Isberg V, Nikolajsen LF, Bibbe JM, Flock T, Hanson MA, Stevens RC, Deupi X, Gloriam DE
Nature methods, 2019, 16:151-162