GPCRdb contains reference data, interactive visualisation and experiment design tools for G protein-coupled receptors (GPCRs). GPCRdb curates sequence alignments, structures and receptor mutations from literature. Interactive diagrams visualise receptor residues (e.g. snakeplot and helix box plot) and relationships (e.g phylogenetic trees). See the GPCRdb graphical overview, video, articles or documentation.

GproteinDb has been, and ArrestinDb will be, published as separate web resources.

GPCRdb is developed by the David Gloriam group, integrates data from the large GPCR community and maintains an active collaboration with the Guide To Pharmacology (IUPHAR), GPCRmd and ERNEST. If you use the GPCRdb, please remember to cite us.

GPCRdb statistics

  • 424 Human proteins
  • 43,132 Species orthologs
  • 69,605 Genetic variants
  • 1,789 Drugs
  • 209,520 Ligands
  • 432,715 Ligand bioactivities
  • 35,189 Ligand site mutations
  • 24,919 Ligand interactions
  • Experimental structures
  • 757 GPCRs
  • 399 G proteins
  • Structure models
  • 967 GPCRs
  • 3,091 GPCR-G protein complexes
  • 672 Refined GPCR structures
GPCRdb, GproteinDb, and ArrestinDb had 53,336 different users since this date last year and 5,515 users in the last 30 days (Google Analytics).

Latest release

April 30, 2022
  • Updated GPCR and G protein structures.
  • Updated GPCR ligand and bioactivity data to ChEMBL v30.
  • Updated GPCR homology and refined structure models.
  • Minor bug and performance fixes.