
GPCRdb contains data, diagrams and web tools for G protein-coupled receptors (GPCRs). Users can browse all GPCR structures and the largest collections of receptor mutants. Diagrams can be produced and downloaded to illustrate receptor residues (snake-plot and helix box diagrams) and relationships (phylogenetic trees). Reference (structure) structure-based sequence alignments take into account helix bulges and constrictions, display statistics of amino acid conservation and have been assigned generic residue numbering for equivalent residues in different receptors. For an overview read the GPCRdb poster, articles or documentation.
Latest release
Oct. 25, 2019- Updated GPCR structures and statistics
- Updated homology and refined models
- GPCR-G protein complex structure models
- New G protein browser
GPCRdb statistics
- Proteins: 15,149
- Human proteins: 420 (all non-olfactory)
- Species: 3,547
- Exp. structures: 346
- Refined structures: 263
- GPCR structure models: 1,007
- GPCR-G protein structure models: 2,100
- Ligands: 144,917
- Mutants: 34,248
- Ligand interactions: 16,781
Partner GPCR databases
Legacy GPCRdb database(Radboudumc Nijmegen), GuideToPharmacology (IUPHAR), tinyGRAP (Tromsø, Norway), GPCR-OKB (Weill Medical College), NaVa (Leiden Uni.) and Swiss-Prot.
Supported by ERNEST (COST Action CA18133)
Partner GPCR servers/tools
3D-e-Chem (VU University Amsterdam), GPCRM (Uni. Warsaw), scPDB (Uni. Strasbourg), GPCR-SSFE (Leibniz-Institut, Berlin), GoMoDo (Uni. Verona), GPCR-ModSim (Uppsala Uni.).