Build alignments
Select proteins to align individually or by family. Choose custom sequence segments to include in your alignment.
Build diagrams
Get helix box and/or snake diagrams with custom coloring for you publications.
Automatically add generic numbers to PDB files
Upload PDB files and apply GPCRdb generic numbers.
Plot experimental values onto diagrams
Highlight residues with available mutant and/or ligand interaction data.
Build phylogenetic trees
Customise the sequence segments to use for generating the trees.
The GPCR database (GPCRdb) contains data, diagrams and web tools to help researchers understand G protein-coupled receptors (GPCRs). Users can browse up to date curated GPCR structures and the largest collections of receptor mutants. Diagrams can be produced and downloaded to illustrate receptor residues (snake-plot and helix box diagrams) and relationships (phylogenetic trees). Reference (structure) structure-based sequence alignments take into account helix bulges and constrictions, display statistics of amino acid conservation and have been assigned generic residue numbering for equivalent residues in different receptors. For an overview read the GPCRdb poster, articles or documentation.
Latest release
Oct. 25, 2019- Updated GPCR structures and statistics
- Updated homology and refined models
- GPCR-G protein complex structure models
- New G protein browser
GPCRdb statistics
- Proteins: 28,008
- Human proteins: 423 (all non-olfactory)
- Species: 4,621
- Exp. structures: 421
- Refined structures: 305
- GPCR structure models: 883
- GPCR-G protein structure models: 2,163
- Ligands: 145,568
- Mutants: 35,024
- Ligand interactions: 21,483
Partner GPCR databases
GuideToPharmacology (IUPHAR), GPCR-OKB (Weill Medical College), NaVa (Leiden Uni.), and Swiss-Prot
Supported by ERNEST (COST Action CA18133)
Partner GPCR servers/tools
3D-e-Chem (VU University Amsterdam), GPCRM (Uni. Warsaw), scPDB (Uni. Strasbourg), GPCR-SSFE (Leibniz-Institut, Berlin), GoMoDo (Uni. Verona), GPCR-ModSim (Uppsala Uni.).