New state-specific structure models
Models and refined structures using AlphaFold2.
New ligand resources
Endogenous ligands and tool compounds.
New structure analysis resource
Structure comparison tool and similarity trees.
Alignments and Trees
Customized sequence alignments and phylogenetic trees .
GPCRdb
G protein-coupled receptors (GPCRs) are cell-surface receptors mediating the responses of 2/3rds of human hormones1 and 1/3rd of
drugs2.
Each GPCR can bind several transducers, G proteins, GPCR kinases (GRKs) and arrestins
leading to distinct intracellular signaling networks and functional outcomes.
Data
- 423 Human proteins
- 40,422 Species orthologs
- 69,580 Genetic variants
- 968 Drugs
- 175 Drug targets
- 405 Disease indications
- 217,565 Ligands
- 527 Endogenous ligands
- 488,534 Ligand bioactivities
- 36,127 Ligand site mutations
- 45,112 Ligand interactions
- 1,102 GPCRs structures
- 844 GPCRs structure models
- 2,954 Generic residues
- 488 Refined structures
Latest release
Oct. 25, 2023- New GPCR - G protein couplings with dedicated pages describing the datasets and biosensors
- Coupling selectivity tree and Venn updated with new coupling data
- Structural superposition for all type of models (complex, non-complex)
- Structural superposition for G protein structures and complex models
- Full G protein heterotrimer AlphaFold2-Multimer complex models increased to 1121
- Minor bug and performance fixes
All releases
Publications
GPCRdb in 2023: State-specific structure models using AlphaFold2 and expansion of ligand resources.
Pándy-Szekeres, G., Caroli, J., Mamyrbekov, A., Kermani, A.A., Keserű, G.M., Kooistra, A.J. and Gloriam, D.E.
Nucleic Acids Research, 2023
GPCRdb in 2021: integrating GPCR sequence, structure and function.
Kooistra AJ, Mordalski S, Pandy-Szekeres G, Esguerra M, Mamyrbekov A, Munk C, Keseru GM, Gloriam DE
Nucleic acids research, 2021, 49:D335-D343
Structure of the class D GPCR Ste2 dimer coupled to two G proteins.
Velazhahan V, Ma N, Pandy-Szekeres G, Kooistra AJ, Lee Y, Gloriam DE, Vaidehi N, Tate CG
Nature, 2021, 589:148-153
An online GPCR structure analysis platform.
Kooistra AJ, Munk C, Hauser AS, Gloriam DE
Nature structural & molecular biology, 2021, 28:875-878
Combinatorial expression of GPCR isoforms affects signalling and drug responses.
Marti-Solano M, Crilly SE, Malinverni D, Munk C, Harris M, Pearce A, Quon T, Mackenzie AE, Wang X, Peng J, Tobin AB, Ladds G, Milligan G, Gloriam DE, Puthenveedu MA, Babu MM
Nature, 2020, 587:650-656
An online resource for GPCR structure determination and analysis.
Munk C, Mutt E, Isberg V, Nikolajsen LF, Bibbe JM, Flock T, Hanson MA, Stevens RC, Deupi X, Gloriam DE
Nature methods, 2019, 16:151-162