GPCRdb contains reference data, interactive visualisation and experiment design tools for G protein-coupled receptors (GPCRs). GPCRdb curates sequence alignments, structures and receptor mutations from literature. Interactive diagrams visualise receptor residues (e.g. snakeplot and helix box plot) and relationships (e.g phylogenetic trees). See the GPCRdb graphical overview, video, articles or documentation.

GPCRdb is developed by the David Gloriam group, integrates data from the large GPCR community and maintains an active collaboration with the Guide To Pharmacology (IUPHAR), GPCRmd and ERNEST. If you use the GPCRdb, please remember to cite us.

GPCRdb statistics

  • Human proteins: 424
  • Species orthologs: 43,090
  • Structures: GPCRs: 512, G proteins: 201
  • Structure models: GPCRs: 962, GPCR-G protein complexes: 2163
  • Refined GPCR structures: 436
  • Genetic variants: 69,605
  • Drugs: 1,789
  • Ligands: 198,616
  • Ligand site mutations: 34,662
  • Ligand interactions: 26,276
GPCRdb had 38,558 different users since this date last year and 5,042 users in the last 30 days (Google Analytics).

Latest release

Feb. 11, 2021
  • Improved structure download and superpositioning workflow.
  • Updated GPCR structures.
  • Updated GPCR homology and refined structure models.
  • Minor bug and performance fixes.