The GPCR database (GPCRdb) contains data, diagrams and web tools to help researchers understand G protein-coupled receptors (GPCRs). Users can browse up to date curated GPCR structures and the largest collections of receptor mutants. Diagrams can be produced and downloaded to illustrate receptor residues (snake-plot and helix box diagrams) and relationships (phylogenetic trees). Reference (structure) structure-based sequence alignments take into account helix bulges and constrictions, display statistics of amino acid conservation and have been assigned generic residue numbering for equivalent residues in different receptors. For an overview read the GPCRdb poster, articles or documentation.

Latest release

Oct. 25, 2019 Recent additions (not reported here earlier)

GPCRdb statistics

  • Proteins: 28,008
  • Human proteins: 423 (all non-olfactory)
  • Species: 4,621
  • Exp. structures: 421
  • Refined structures: 305
  • GPCR structure models: 883
  • GPCR-G protein structure models: 2,163
  • Ligands: 145,568
  • Mutants: 35,024
  • Ligand interactions: 21,483
GPCRdb had 37,752 users since this date last year and 4,115 users in the last 30 days (Google Analytics).

Partner GPCR databases

GuideToPharmacology (IUPHAR), GPCR-OKB (Weill Medical College), NaVa (Leiden Uni.), and Swiss-Prot

Supported by ERNEST (COST Action CA18133)

Partner GPCR servers/tools

3D-e-Chem (VU University Amsterdam), GPCRM (Uni. Warsaw), scPDB (Uni. Strasbourg), GPCR-SSFE (Leibniz-Institut, Berlin), GoMoDo (Uni. Verona), GPCR-ModSim (Uppsala Uni.).