New state-specific structure models
Models and refined structures using AlphaFold2.
New ligand resources
Endogenous ligands and tool compounds.
New structure analysis resource
Structure comparison tool and similarity trees.
Alignments and Trees
Customized sequence alignments and phylogenetic trees .
GPCRdb
G protein-coupled receptors (GPCRs) are cell-surface receptors mediating the responses of 2/3rds of human hormones1 and 1/3rd of
drugs2.
Each GPCR can bind several transducers, G proteins, GPCR kinases (GRKs) and arrestins
leading to distinct intracellular signaling networks and functional outcomes.
Data
- 423 Human proteins
- 42,641 Species orthologs
- 69,602 Genetic variants
- 974 Drugs
- 174 Drug targets
- 411 Disease indications
- 211,408 Ligands
- 543 Endogenous ligands
- 470,789 Ligand bioactivities
- 35,131 Ligand site mutations
- 25,935 Ligand interactions
- 793 GPCRs structures
- 844 GPCRs structure models
- 2,910 Generic residues
- 663 Refined structures
Latest release
Nov. 3, 2022- New refined GPCR structures using AlphaFold
- New full-length and state-specific AlphaFold models for all human GPCRs
- New functionality for searching ligands by name, database identifier, or SMILES/InChIKey
- Updated the ligand and bioactivity pages
- Updated GPCR ligands and bioactivities with data from Guide to Pharmacology and PDSP Ki
- Updated the new Endogenous ligands browser
- Minor bug and performance fixes
All releases
Publications
GPCRdb in 2023: State-specific structure models using AlphaFold2 and expansion of ligand resources.
Pándy-Szekeres, G., Caroli, J., Mamyrbekov, A., Kermani, A.A., Keserű, G.M., Kooistra, A.J. and Gloriam, D.E.
Nucleic Acids Research, 2023
GPCRdb in 2021: integrating GPCR sequence, structure and function.
Kooistra AJ, Mordalski S, Pandy-Szekeres G, Esguerra M, Mamyrbekov A, Munk C, Keseru GM, Gloriam DE
Nucleic acids research, 2021, 49:D335-D343
Structure of the class D GPCR Ste2 dimer coupled to two G proteins.
Velazhahan V, Ma N, Pandy-Szekeres G, Kooistra AJ, Lee Y, Gloriam DE, Vaidehi N, Tate CG
Nature, 2021, 589:148-153
An online GPCR structure analysis platform.
Kooistra AJ, Munk C, Hauser AS, Gloriam DE
Nature structural & molecular biology, 2021, 28:875-878
Combinatorial expression of GPCR isoforms affects signalling and drug responses.
Marti-Solano M, Crilly SE, Malinverni D, Munk C, Harris M, Pearce A, Quon T, Mackenzie AE, Wang X, Peng J, Tobin AB, Ladds G, Milligan G, Gloriam DE, Puthenveedu MA, Babu MM
Nature, 2020, 587:650-656
An online resource for GPCR structure determination and analysis.
Munk C, Mutt E, Isberg V, Nikolajsen LF, Bibbe JM, Flock T, Hanson MA, Stevens RC, Deupi X, Gloriam DE
Nature methods, 2019, 16:151-162