GPCRdb contains data, diagrams and web tools for G protein-coupled receptors (GPCRs). Users can browse all GPCR structures and the largest collections of receptor mutants. Diagrams can be produced and downloaded to illustrate receptor residues (snake-plot and helix box diagrams) and relationships (phylogenetic trees). Reference (structure) structure-based sequence alignments take into account helix bulges and constrictions, display statistics of amino acid conservation and have been assigned generic residue numbering for equivalent residues in different receptors. For an overview read the GPCRdb poster, articles or documentation.

Latest release

Jan. 21, 2019

GPCRdb statistics

  • Proteins: 15,086
  • Human proteins: 417 (all non-olfactory)
  • Species: 3,547
  • Exp. structures: 310
  • Refined structures: 0
  • Ligands: 144,892
  • Mutants: 34,440
  • Ligand interactions: 15,452

Partner GPCR databases

Legacy GPCRdb database(Radboudumc Nijmegen), GuideToPharmacology (IUPHAR), tinyGRAP (Tromsø, Norway), GPCR-OKB (Weill Medical College), NaVa (Leiden Uni.) and Swiss-Prot.

Supported by GLISTEN (COST Action CM1207)

Partner GPCR servers/tools

3D-e-Chem (VU University Amsterdam), GPCRM (Uni. Warsaw), scPDB (Uni. Strasbourg), GPCR-SSFE (Leibniz-Institut, Berlin), GoMoDo (Uni. Verona), GPCR-ModSim (Uppsala Uni.).