GPCRdb contains reference data, interactive visualisation and experiment design tools for G protein-coupled receptors (GPCRs). GPCRdb curates sequence alignments, structures and receptor mutations from literature. Interactive diagrams visualise receptor residues (e.g. snakeplot and helix box plot) and relationships (e.g phylogenetic trees). See the GPCRdb graphical overview, video, articles or documentation.

GPCRdb is developed by the David Gloriam group, integrates data from the large GPCR community and maintains an active collaboration with the Guide To Pharmacology (IUPHAR), GPCRmd and ERNEST. If you use the GPCRdb, please remember to cite us.

GPCRdb statistics

  • 424 Human proteins
  • 43,092 Species orthologs
  • 69,605 Genetic variants
  • 1,789 Drugs
  • 199,309 Ligands
  • 34,696 Ligand site mutations
  • 28,301 Ligand interactions
  • Experimental structures
  • 557 GPCRs
  • 237 G proteins
  • Structure models
  • 1,006 GPCRs
  • 3,069 GPCR-G protein complexes
  • 490 Refined GPCR structures
GPCRdb had 38,152 different users since this date last year and 3,835 users in the last 30 days (Google Analytics).

Latest release

June 14, 2021