Data showed in this table is continously collected from the Guide to Pharmacology database. Ref
| Receptor | Endogenous ligands | pEC50 | pKi | References | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Class | Receptor family | UniProt | IUPHAR | Species | Ligand | GtP Classification |
Potency Ranking |
Type | Min | Mid | Max | Min | Mid | Max | |
| A (Rhodopsin) | Class A orphan | GPR17 | GPR17 | Mouse | Ltd4 | None | 3 | Small molecule | 8.1 | 8.3 | 8.4 | Refs | |||
| A (Rhodopsin) | Urotensin | UR2R | UT | Human | Urotensin-Ii | 2 | Peptide | 8.2 | 8.6 | 9.0 | Refs | ||||
| A (Rhodopsin) | Neurotensin | NTR1 | NTS1 | Rat | Neurotensin | 1 | Peptide | 8.3 | 9.0 | 9.7 | Refs | ||||
| A (Rhodopsin) | Opioid | OPRD | δ | Human | Dynorphin A-(1-13) | 4 | Peptide | 7.8 | 7.8 | Refs | |||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT4R | 5-HT4 | Rat | 5-Hydroxytryptamine | None | Small molecule | 6.7 | 7.5 | 8.2 | Refs | ||||
| A (Rhodopsin) | Histamine | HRH4 | H4 | Rat | Histamine | None | 1 | Small molecule | 7.8 | 7.4 | 7.4 | Refs | |||
| A (Rhodopsin) | Chemerin | CML1 | hemerin | Human | 18r-Hepe | 2 | Small molecule | ||||||||
| C (Glutamate) | Metabotropic glutamate | GRM4 | mGlu4 | Human | L-Glutamic Acid | None | 2 | Small molecule | 4.7 | 5.1 | 5.5 | 4.9 | 5.2 | 5.5 | Refs |
| A (Rhodopsin) | Lysophospholipid (S1P) | S1PR1 | S1P1 | Mouse | Sphingosine 1-Phosphate | None | 1 | Small molecule | 7.1 | 8.7 | 9.5 | Refs | |||
| A (Rhodopsin) | Lysophospholipid (LPA) | LPAR1 | LPA1 | Mouse | Lpa | None | Small molecule | 7.9 | 8.1 | 8.3 | Refs | ||||
| A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Human | Srif-14 | 4 | Peptide | 7.7 | 8.4 | 9.1 | Refs | ||||
| A (Rhodopsin) | Opioid | OPRK | κ | Mouse | Α-Neoendorphin | 3 | Peptide | 8.3 | 9.3 | 10.2 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Rat | Pgf2Α | Secondary | Small molecule | 6.2 | 6.3 | 6.3 | Refs | ||||
| A (Rhodopsin) | Neurotensin | NTR2 | NTS2 | Rat | Neurotensin | 1 | Peptide | 8.8 | 8.8 | Refs | |||||
| A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Rat | Pgd2 | Secondary | Small molecule | 8.8 | 8.8 | 8.7 | 5.9 | 5.9 | Refs | ||
| A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Human | Pgf2Α | Secondary | Small molecule | 5.2 | 5.6 | 5.6 | Refs | ||||
| A (Rhodopsin) | Melanocortin | MC4R | MC4 | Human | Α-Msh | Secondary | Peptide | 7.4 | 7.7 | 8.0 | Refs | ||||
| A (Rhodopsin) | Chemokine | CCR7 | CCR7 | Mouse | Ccl19 | Peptide | Refs | ||||||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT7R | 5-HT7 | Human | 5-Hydroxytryptamine | None | Small molecule | 8.1 | 8.9 | 9.6 | Refs | ||||
| A (Rhodopsin) | Neuromedin U | NMUR1 | NMU1 | Human | Neuromedin U-25 | 2 | Peptide | 8.4 | 8.9 | 9.4 | 9.5 | 9.5 | Refs | ||
| B1 (Secretin) | Parathyroid hormone | PTH2R | PTH2 | Human | Tip39 | Peptide | |||||||||
| A (Rhodopsin) | Opioid | OPRK | κ | Human | Α-Neoendorphin | 3 | Peptide | 8.3 | 9.3 | 10.2 | Refs | ||||
| A (Rhodopsin) | GPR18, GPR55 and GPR119 | GP119 | GPR119 | Human | N-Oleoylethanolamide | None | 1 | Small molecule | 5.4 | 5.9 | 6.3 | Refs | |||
| B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Rat | Vip | Principal | Peptide | 7.9 | 9.0 | 10.0 | 8.5 | 9.2 | 9.8 | Refs | |
| A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Rat | Pge1 | Secondary | Small molecule | 9.5 | 9.5 | 8.7 | 8.7 | Refs | |||
| A (Rhodopsin) | Galanin | GALR1 | GAL1 | Mouse | Galanin | 1 | Peptide | 9.8 | 9.8 | 9.3 | 9.8 | 10.3 | Refs | ||
| A (Rhodopsin) | Galanin | GALR1 | GAL1 | Human | Galanin | 2 | Peptide | 9.2 | 9.6 | 9.9 | Refs | ||||
| A (Rhodopsin) | Succinate | SUCR1 | succinate | Human | Succinic Acid | None | 2 | Small molecule | 3.1 | 3.9 | 4.7 | Refs | |||
| A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF1 | NPFF1 | Human | Neuropeptide Sf | 3 | Peptide | ||||||||
| A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Rat | Tyramine | None | 2 | Small molecule | 6.2 | 6.7 | 7.1 | 6.4 | 6.4 | Refs | |
| A (Rhodopsin) | Peptide P518 | QRFPR | QRFP | Human | Qrfp26 (26rfa) | 2 | Peptide | 8.1 | 8.1 | Refs | |||||
| A (Rhodopsin) | Chemokine | ACKR2 | ACKR2 | Human | Ccl11 | Peptide | |||||||||
| B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Human | Vip | Principal | Peptide | 7.9 | 9.0 | 10.0 | 8.5 | 9.2 | 9.8 | Refs | |
| A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Rat | Srif-28 | 3 | Peptide | 8.1 | 9.0 | 9.9 | Refs | ||||
| A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Human | Srif-28 | 2 | Peptide | 8.4 | 9.3 | 10.2 | Refs | ||||
| A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl11 | Principal | Peptide | 9.7 | 9.9 | 10.0 | Refs | ||||
| C (Glutamate) | Calcium-sensing | CASR | CaS | Rat | Ca2+ | None | Small molecule | Refs | |||||||
| A (Rhodopsin) | Apelin | APJ | apelin | Human | [Pyr1]Apelin-13 | Peptide | Refs | ||||||||
| A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Human | Pgf2Α | Secondary | Small molecule | 6.2 | 6.3 | 6.3 | Refs | ||||
| A (Rhodopsin) | Chemokine | CXCR2 | CXCR2 | Mouse | Cxcl8 | 2 | Peptide | 8.8 | 6.4 | 6.4 | Refs | ||||
| A (Rhodopsin) | Vasopressin and oxytocin | V2R | V2 | Human | Vasopressin | Principal | Peptide | 7.9 | 8.5 | 9.1 | Refs | ||||
| A (Rhodopsin) | Hydroxycarboxylic acid | HCAR2 | HCA2 | Human | Butyric Acid | None | 2 | Small molecule | 2.8 | 2.8 | |||||
| A (Rhodopsin) | Opioid | OPRK | κ | Rat | Β-Neoendorphin | 4 | Peptide | 9.1 | 9.1 | Refs | |||||
| A (Rhodopsin) | Somatostatin | SSR1 | SST1 | Rat | Srif-14 | 2 | Peptide | 8.6 | 9.1 | 9.5 | Refs | ||||
| A (Rhodopsin) | Bombesin | GRPR | BB2 | Rat | Gastrin-Releasing Peptide | 2 | Peptide | 6.3 | 7.3 | 8.2 | Refs | ||||
| A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Mouse | Srif-28 | 3 | Peptide | 8.1 | 9.0 | 9.9 | Refs | ||||
| A (Rhodopsin) | Bombesin | GRPR | BB2 | Human | Gastrin-Releasing Peptide | 2 | Peptide | 6.3 | 7.3 | 8.2 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PF2R | FP | Human | Pge2 | Secondary | Small molecule | 6.4 | 7.0 | 7.0 | Refs | ||||
| A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl7 | Secondary | Peptide | 8.6 | 8.9 | 9.2 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Rat | Pgd2 | None | 1 | Small molecule | 7.4 | 7.5 | 7.5 | Refs | |||
| B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Rat | Urocortin 3 | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Human | Kallidin | 3 | Peptide | 7.0 | 8.0 | 8.9 | Refs | ||||
| A (Rhodopsin) | Opioid | OPRM | μ | Human | Β-Endorphin | 6 | Peptide | ||||||||
| A (Rhodopsin) | Chemokine | CXCR2 | CXCR2 | Human | Cxcl1 | 1 | Peptide | 8.4 | 8.1 | 8.1 | Refs | ||||
| A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl16 | Secondary | Peptide | ||||||||
| A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl4 | 8 | Peptide | ||||||||
| A (Rhodopsin) | Tachykinin | NK2R | NK2 | Human | Substance P | Secondary | Peptide | 5.9 | 6.4 | 6.9 | Refs | ||||
| A (Rhodopsin) | Lysophospholipid (LPA) | LPAR5 | LPA5 | Human | Lpa | None | 3 | Small molecule | 4.3 | 6.1 | 7.9 | Refs | |||
| A (Rhodopsin) | Chemokine | CXCR3 | CXCR3 | Human | Cxcl11 | 9 | Peptide | ||||||||
| A (Rhodopsin) | Somatostatin | SSR4 | SST4 | Human | Cortistatin-14 | 3 | Peptide | 8.6 | 8.7 | 8.8 | Refs | ||||
| A (Rhodopsin) | Melanocortin | MC5R | MC5 | Human | Γ-Msh | Secondary | Peptide | ||||||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT2B | 5-HT2B | Rat | 5-Hydroxytryptamine | None | Small molecule | 7.9 | 8.0 | 8.0 | Refs | ||||
| A (Rhodopsin) | Peptide P518 | QRFPR | QRFP | Mouse | Qrfp43 | 4 | Peptide | 6.7 | 7.0 | 7.2 | Refs | ||||
| A (Rhodopsin) | Adren | ADRB3 | β3-adren | Human | (&Plusmn;)-Adrenaline | None | 1 | Small molecule | 3.9 | 5.3 | 5.3 | Refs | |||
| A (Rhodopsin) | Complement peptide | C5AR1 | C5a1 | Human | C3a | 2 | Peptide | ||||||||
| A (Rhodopsin) | Opioid | OPRK | κ | Mouse | Dynorphin A | 1 | Peptide | 10.0 | 10.2 | 10.3 | Refs | ||||
| A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Human | Uridine Diphosphate | None | 3 | Small molecule | 7.1 | 7.1 | Refs | ||||
| A (Rhodopsin) | Urotensin | UR2R | UT | Mouse | Urotensin-Ii | 2 | Peptide | 8.2 | 8.6 | 9.0 | Refs | ||||
| A (Rhodopsin) | Chemokine | ACKR2 | ACKR2 | Human | Ccl2 | Peptide | |||||||||
| A (Rhodopsin) | Lysophospholipid (S1P) | S1PR2 | S1P2 | Human | Sphingosine 1-Phosphate | None | 1 | Small molecule | 8.1 | 8.3 | 8.5 | Refs | |||
| A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Rat | [Des-Arg10]Kallidin | 2 | Peptide | 8.7 | 8.8 | 8.8 | Refs | ||||
| A (Rhodopsin) | Complement peptide | C5AR1 | C5a1 | Human | C5a | 1 | Peptide | 8.0 | 8.5 | 9.0 | Refs | ||||
| A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Rat | Kallidin | 3 | Peptide | 7.0 | 8.0 | 8.9 | Refs | ||||
| A (Rhodopsin) | Galanin | GALR1 | GAL1 | Rat | Galanin | 1 | Peptide | 9.8 | 9.8 | 9.3 | 9.8 | 10.3 | Refs | ||
| A (Rhodopsin) | Formylpeptide | FPR3 | FPR3 | Human | F2l | 4 | Peptide | ||||||||
| A (Rhodopsin) | Neuromedin U | NMUR2 | NMU2 | Human | Neuromedin S-33 | 1 | Peptide | 10.0 | 10.0 | Refs | |||||
| A (Rhodopsin) | Free fatty acid | FFAR4 | FFA4 | Rat | Α-Linolenic Acid | None | 2 | Small molecule | 5.5 | 5.5 | Refs | ||||
| A (Rhodopsin) | Bombesin | NMBR | BB1 | Human | Neuromedin B | 1 | Peptide | 8.1 | 9.2 | 10.3 | Refs | ||||
| A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Neuropeptide W-30 | Peptide | Refs | ||||||||
| A (Rhodopsin) | Adren | ADA1B | α1B-adren | Human | (-)-Adrenaline | None | 1 | Small molecule | 6.5 | 6.5 | Refs | ||||
| A (Rhodopsin) | Lysophospholipid (S1P) | S1PR1 | S1P1 | Human | Sphingosine 1-Phosphate | None | 1 | Small molecule | 7.1 | 8.7 | 9.5 | Refs | |||
| C (Glutamate) | Metabotropic glutamate | GRM8 | mGlu8 | Human | L-Serine-O-Phosphate | None | 2 | Small molecule | Refs | ||||||
| A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF2 | NPFF2 | Human | Prrp-31 | 2 | Peptide | ||||||||
| A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Gastrin-17 | Peptide | |||||||||
| A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Mouse | Pancreatic Polypeptide | Secondary | Peptide | 10.5 | 10.6 | 10.6 | Refs | ||||
| A (Rhodopsin) | Chemokine | ACKR4 | ACKR4 | Human | Ccl25 | 3 | Peptide | 7.9 | 8.1 | 8.3 | 7.6 | 7.6 | Refs | ||
| A (Rhodopsin) | Somatostatin | SSR4 | SST4 | Human | Srif-14 | 2 | Peptide | 8.4 | 8.9 | 9.3 | Refs | ||||
| B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Human | Pacap-27 | Principal | Peptide | 7.4 | 8.9 | 10.6 | 6.9 | 8.0 | 8.5 | Refs | |
| A (Rhodopsin) | Histamine | HRH1 | H1 | Human | Histamine | None | Small molecule | 4.7 | 5.3 | 5.9 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Mouse | Pgj2 | None | 3 | Small molecule | 7.3 | 7.3 | Refs | ||||
| B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Rat | Pacap-27 | Principal | Peptide | 7.4 | 8.9 | 10.6 | 6.9 | 8.0 | 8.5 | Refs | |
| A (Rhodopsin) | Vasopressin and oxytocin | V1BR | V1B | Rat | Vasopressin | Principal | Peptide | 9.0 | 9.9 | 9.9 | Refs | ||||
| A (Rhodopsin) | Lysophospholipid (S1P) | S1PR5 | S1P5 | Human | Sphingosine 1-Phosphate | None | 1 | Small molecule | 7.4 | 8.2 | 8.9 | Refs | |||
| A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Mouse | Humanin | 6 | Peptide | 6.0 | 6.5 | 7.0 | Refs | ||||
| A (Rhodopsin) | Melatonin | MTR1B | MT2 | Human | Melatonin | None | Small molecule | 9.4 | 9.6 | 9.8 | Refs | ||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT7R | 5-HT7 | Mouse | 5-Hydroxytryptamine | None | Small molecule | 8.1 | 8.9 | 9.6 | Refs | ||||
| A (Rhodopsin) | Proteinase-activated | PAR3 | PAR3 | Human | Thrombin | Peptide | |||||||||
| A (Rhodopsin) | GPR18, GPR55 and GPR119 | GPR55 | GPR55 | Human | 2-Arachidonoylglycerolphosphoinositol | None | 5 | Small molecule | Refs | ||||||
| A (Rhodopsin) | Class A orphan | GPR17 | GPR17 | Human | Udp-Glucose | None | 4 | Small molecule | 5.9 | 7.7 | 9.5 | Refs | |||
| A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Rat | Pge2 | Principal | Small molecule | 9.4 | 9.4 | 9.0 | 9.0 | Refs | |||
| A (Rhodopsin) | Lysophospholipid (LPA) | LPAR2 | LPA2 | Human | Lpa | None | 1 | Small molecule | 8.0 | 8.1 | 8.2 | Refs | |||
| A (Rhodopsin) | Neuropeptide S | NPSR1 | NPS | Human | Neuropeptide S | Peptide | 8.5 | 8.5 | Refs | ||||||
| A (Rhodopsin) | Free fatty acid | FFAR2 | FFA2 | Human | Butyric Acid | None | 4 | Small molecule | 2.9 | 3.8 | 4.6 | Refs | |||
| A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Rat | Uridine Diphosphate | None | 3 | Small molecule | 7.1 | 7.1 | Refs | ||||
| A (Rhodopsin) | Class A orphan | LGR6 | LGR6 | Human | R-Spondin-4 | Peptide | Refs | ||||||||
| A (Rhodopsin) | Opioid | OPRK | κ | Rat | Dynorphin A-(1-13) | 2 | Peptide | 9.3 | 10.0 | 10.7 | Refs | ||||
| A (Rhodopsin) | Class A orphan | LGR5 | LGR5 | Human | R-Spondin-3 | 3 | Peptide | 11.0 | 11.0 | Refs | |||||
| A (Rhodopsin) | Complement peptide | C5AR2 | C5a2 | Human | C5a | 1 | Peptide | 8.9 | 8.9 | Refs | |||||
| A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl23 | Principal | Peptide | 8.9 | 8.9 | Refs | |||||
| A (Rhodopsin) | Melanocortin | MSHR | MC1 | Mouse | Agouti | Secondary | Peptide | Refs | |||||||
| A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Human | Udp N-Acetyl-Glucosamine | None | 5 | Small molecule | 6.0 | 6.0 | Refs | ||||
| A (Rhodopsin) | Complement peptide | C5AR1 | C5a1 | Human | C3a | 2 | Peptide | ||||||||
| A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Rat | Pge1 | Secondary | Small molecule | 9.4 | 9.4 | 9.0 | 9.0 | Refs | |||
| A (Rhodopsin) | Leukotriene | LT4R2 | BLT2 | Human | 12-Hydroxyheptadecatrienoic Acid | None | 1 | Small molecule | 7.7 | 7.7 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Mouse | Pge2 | Principal | Small molecule | 6.1 | 6.1 | 8.5 | 9.0 | 9.0 | Refs | ||
| A (Rhodopsin) | Adenosine | AA3R | A3 | Rat | Adenosine | None | Small molecule | 6.5 | 6.5 | Refs | |||||
| A (Rhodopsin) | Galanin | GALR1 | GAL1 | Human | Galanin-Like Peptide | 2 | Peptide | ||||||||
| A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Rat | Β-Phenylethylamine | None | 3 | Small molecule | 6.4 | 6.5 | 6.6 | Refs | |||
| A (Rhodopsin) | Vasopressin and oxytocin | V1AR | V1A | Human | Vasopressin | Principal | Peptide | 8.5 | 8.4 | 8.4 | Refs | ||||
| B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Mouse | Urocortin 2 | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | Chemerin | CML1 | hemerin | Human | Chemerin | 1 | Peptide | 7.6 | 8.0 | 8.5 | Refs | ||||
| A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl7 | Secondary | Peptide | ||||||||
| A (Rhodopsin) | Galanin | GALR2 | GAL2 | Rat | Galanin | 2 | Peptide | 8.3 | 8.3 | 8.3 | 8.8 | 9.3 | Refs | ||
| A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Mouse | Cortistatin-14 | 2 | Peptide | 8.7 | 9.1 | 9.4 | Refs | ||||
| A (Rhodopsin) | Complement peptide | C5AR1 | C5a1 | Human | C5a Des-Arg | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Mouse | Pge2 | Principal | Small molecule | 7.3 | 7.7 | 8.0 | Refs | ||||
| B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Human | Pacap-38 | Principal | Peptide | 9.5 | 9.8 | 10.0 | 6.9 | 8.2 | 9.0 | Refs | |
| A (Rhodopsin) | Somatostatin | SSR4 | SST4 | Rat | Srif-14 | 2 | Peptide | 8.4 | 8.9 | 9.3 | Refs | ||||
| A (Rhodopsin) | Melanocortin | MC3R | MC3 | Human | Γ-Msh | Principal | Peptide | Refs | |||||||
| A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Human | Srif-28 | 3 | Peptide | 8.1 | 9.0 | 9.9 | Refs | ||||
| A (Rhodopsin) | Dopamine | DRD3 | D3 | Human | Dopamine | None | Small molecule | 6.4 | 6.9 | 7.3 | Refs | ||||
| A (Rhodopsin) | Class A orphan | TAAR3 | TAAR3 | Mouse | Isoamylamine | None | Small molecule | 5.0 | 5.0 | Refs | |||||
| A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF2 | NPFF2 | Human | Neuropeptide Af | 2 | Peptide | ||||||||
| A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Mouse | Pge2 | Principal | Small molecule | 9.4 | 9.4 | 9.0 | 9.0 | Refs | |||
| A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Human | Pge2 | Principal | Small molecule | 6.1 | 6.1 | 8.5 | 9.0 | 9.0 | Refs | ||
| C (Glutamate) | Metabotropic glutamate | GRM5 | mGlu5 | Rat | L-Glutamic Acid | None | Small molecule | 5.0 | 5.3 | 5.5 | Refs | ||||
| A (Rhodopsin) | Adenosine | AA3R | A3 | Human | Adenosine | None | Small molecule | 6.5 | 6.5 | Refs | |||||
| A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Cck-8 | Peptide | Refs | ||||||||
| A (Rhodopsin) | Leukotriene | CLTR2 | CysLT2 | Human | Ltd4 | None | 2 | Small molecule | 6.8 | 7.6 | 8.6 | 7.3 | 7.7 | 8.1 | Refs |
| A (Rhodopsin) | Ghrelin | GHSR | ghrelin | Human | Ghrelin | 1 | Peptide | 7.2 | 8.1 | 9.5 | 7.8 | 8.0 | 8.1 | Refs | |
| A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Mouse | [Des-Arg10]Kallidin | 2 | Peptide | 8.7 | 8.8 | 8.8 | Refs | ||||
| A (Rhodopsin) | Chemokine | CX3C1 | CX3CR1 | Human | Cx3Cl1 | Peptide | |||||||||
| A (Rhodopsin) | Bombesin | GRPR | BB2 | Mouse | Neuromedin B | 3 | Peptide | 6.6 | 7.0 | 7.4 | Refs | ||||
| A (Rhodopsin) | Leukotriene | CLTR1 | CysLT1 | Human | Ltd4 | None | 1 | Small molecule | 7.3 | 8.6 | 9.4 | Refs | |||
| A (Rhodopsin) | Chemokine | CCR7 | CCR7 | Human | Ccl21b | Peptide | Refs | ||||||||
| A (Rhodopsin) | Vasopressin and oxytocin | OXYR | OT | Human | Oxytocin | Principal | Peptide | 8.2 | 8.7 | 8.7 | Refs | ||||
| A (Rhodopsin) | Prokineticin | PKR2 | PKR2 | Human | Prokineticin-1 | Peptide | Refs | ||||||||
| A (Rhodopsin) | Bombesin | GRPR | BB2 | Rat | Neuromedin B | 3 | Peptide | 6.6 | 7.0 | 7.4 | Refs | ||||
| A (Rhodopsin) | Opioid | OPRK | κ | Rat | Β-Endorphin | 7 | Peptide | 6.3 | 6.8 | 6.8 | Refs | ||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT4R | 5-HT4 | Mouse | 5-Hydroxytryptamine | None | Small molecule | 6.7 | 7.5 | 8.2 | Refs | ||||
| A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl3 | 5 | Peptide | 8.0 | 8.5 | 8.9 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Rat | Pge2 | Principal | Small molecule | 7.5 | 7.9 | 8.3 | Refs | ||||
| A (Rhodopsin) | P2Y | P2RY4 | P2Y4 | Human | Atp | None | 2 | Small molecule | 5.7 | 5.4 | 5.4 | Refs | |||
| B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Human | Vip | Principal | Peptide | 7.3 | 8.3 | 9.3 | 7.8 | 8.4 | 8.8 | Refs | |
| A (Rhodopsin) | Adren | ADRB1 | β1-adren | Human | (-)-Noradrenaline | None | 2 | Small molecule | 5.5 | 5.8 | 6.0 | Refs | |||
| F (Frizzled) | Frizzled | FZD6 | FZD6 | Human | Wnt-3a | Peptide | Refs | ||||||||
| A (Rhodopsin) | Neuropeptide Y | NPY5R | Y5 | Rat | Pancreatic Polypeptide | Secondary | Peptide | 8.4 | 8.9 | 9.3 | Refs | ||||
| A (Rhodopsin) | Proteinase-activated | PAR3 | PAR3 | Human | Thrombin | Peptide | |||||||||
| A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Mouse | 3-Iodothyronamine | None | 1 | Small molecule | 6.5 | 6.8 | 7.0 | Refs | |||
| A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Human | [Des-Arg9]Bradykinin | 1 | Peptide | 5.7 | 9.2 | 9.2 | Refs | ||||
| A (Rhodopsin) | Melanocortin | MC5R | MC5 | Human | Acth | Secondary | Peptide | ||||||||
| A (Rhodopsin) | Chemokine | CCR8 | CCR8 | Human | Ccl1 | Principal | Peptide | Refs | |||||||
| A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Rat | Pge2 | Principal | Small molecule | 6.1 | 6.1 | 8.5 | 9.0 | 9.0 | Refs | ||
| A (Rhodopsin) | Orexin | OX2R | OX2 | Human | Orexin-A | 1 | Peptide | 6.5 | 8.3 | 10.0 | Refs | ||||
| A (Rhodopsin) | Vasopressin and oxytocin | V1AR | V1A | Rat | Vasopressin | Principal | Peptide | 8.5 | 8.4 | 8.4 | Refs | ||||
| A (Rhodopsin) | Vasopressin and oxytocin | V1AR | V1A | Human | Oxytocin | Secondary | Peptide | 6.9 | 7.6 | 8.3 | Refs | ||||
| A (Rhodopsin) | Histamine | HRH3 | H3 | Mouse | Histamine | None | Small molecule | 7.2 | 7.6 | 7.9 | Refs | ||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1D | 5-HT1D | Human | 5-Hydroxytryptamine | None | 1 | Small molecule | 8.0 | 8.5 | 9.0 | Refs | |||
| A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Human | Srif-14 | 1 | Peptide | 9.0 | 9.1 | 9.1 | 8.9 | 9.7 | 10.5 | Refs | |
| A (Rhodopsin) | Kisspeptin | KISSR | kisspeptin | Human | Kisspeptin-54 | 2 | Peptide | 8.8 | 9.2 | 9.5 | Refs | ||||
| A (Rhodopsin) | Vasopressin and oxytocin | OXYR | OT | Human | Vasopressin | Secondary | Peptide | 7.3 | 8.3 | 9.3 | Refs | ||||
| A (Rhodopsin) | Melanocortin | MSHR | MC1 | Human | Acth | Secondary | Peptide | ||||||||
| A (Rhodopsin) | Cholecystokinin | CCKAR | CCK1 | Human | Cck-33 | Peptide | Refs | ||||||||
| A (Rhodopsin) | Gonadotrophin-releasing hormone | GNRHR | GnRH1 | Mouse | Gnrh I | 1 | Peptide | 7.8 | 7.9 | 7.9 | 7.3 | 8.0 | 8.4 | Refs | |
| A (Rhodopsin) | Adren | ADA2B | α2B-adren | Human | (-)-Noradrenaline | None | 1 | Small molecule | 5.4 | 5.7 | 6.0 | Refs | |||
| A (Rhodopsin) | Tachykinin | NK2R | NK2 | Human | Neurokinin A | Principal | Peptide | 8.9 | 8.9 | 8.0 | 8.6 | 9.1 | Refs | ||
| A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl26 | Secondary | Peptide | Refs | |||||||
| A (Rhodopsin) | Angiotensin | AGTR1 | AT1 | Human | Angiotensin A | 1 | Peptide | 8.2 | 8.2 | 8.8 | 8.8 | Refs | |||
| A (Rhodopsin) | Lysophospholipid (S1P) | S1PR1 | S1P1 | Human | Sphingosylphosphorylcholine | 2 | Small molecule | ||||||||
| A (Rhodopsin) | Peptide P518 | QRFPR | QRFP | Rat | Qrfp43 (43rfa) | 3 | Peptide | 6.9 | 7.8 | 8.6 | Refs | ||||
| A (Rhodopsin) | Hydroxycarboxylic acid | HCAR2 | HCA2 | Human | Β-D-Hydroxybutyric Acid | None | 1 | Small molecule | 3.5 | 3.5 | Refs | ||||
| A (Rhodopsin) | Class A orphan | GPR32 | GPR32 | Human | Resolvin D1 | None | 1 | Small molecule | 11.1 | 11.1 | Refs | ||||
| A (Rhodopsin) | P2Y | P2RY1 | P2Y1 | Human | Adp | None | 2 | Small molecule | Refs | ||||||
| A (Rhodopsin) | Vasopressin and oxytocin | V2R | V2 | Human | Oxytocin | Secondary | Peptide | 5.4 | 6.1 | 6.8 | Refs | ||||
| A (Rhodopsin) | Orexin | OX1R | OX1 | Human | Orexin-A | 1 | Peptide | 6.5 | 8.4 | 10.2 | Refs | ||||
| A (Rhodopsin) | Adren | ADA1A | α1A-adren | Human | (-)-Noradrenaline | None | 2 | Small molecule | 5.8 | 6.1 | 6.4 | Refs | |||
| B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Human | Phi | Secondary | Peptide | ||||||||
| A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Mouse | Udp-Glucuronic Acid | None | 2 | Small molecule | 7.2 | 7.2 | Refs | ||||
| A (Rhodopsin) | Peptide P518 | QRFPR | QRFP | Mouse | Qrfp26 | 1 | Peptide | 8.2 | 8.2 | Refs | |||||
| A (Rhodopsin) | Bombesin | GRPR | BB2 | Mouse | Gastrin-Releasing Peptide | 2 | Peptide | 6.3 | 7.3 | 8.2 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Rat | Pgd2 | Secondary | Small molecule | 5.3 | 5.3 | Refs | |||||
| A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Human | Pgd2 | Secondary | Small molecule | 5.3 | 5.3 | Refs | |||||
| A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl2 | Principal | Peptide | ||||||||
| A (Rhodopsin) | Cholecystokinin | CCKAR | CCK1 | Rat | Cck-33 | Peptide | Refs | ||||||||
| B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Human | Urocortin 1 | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | Prostanoid | PF2R | FP | Human | Pgi2 | Secondary | Small molecule | ||||||||
| A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Gastrin-34 | Peptide | |||||||||
| A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Human | Cst-17 | 1 | Peptide | 8.8 | 9.3 | 9.8 | Refs | ||||
| A (Rhodopsin) | Galanin | GALR3 | GAL3 | Rat | Galanin | 2 | Peptide | 8.1 | 8.5 | 8.8 | Refs | ||||
| A (Rhodopsin) | Acetylcholine receptors (muscarinic) | ACM3 | M3 | Human | Acetylcholine | None | Small molecule | 4.5 | 5.0 | 5.4 | Refs | ||||
| A (Rhodopsin) | Vasopressin and oxytocin | OXYR | OT | Rat | Oxytocin | Principal | Peptide | 8.2 | 8.7 | 8.7 | Refs | ||||
| A (Rhodopsin) | Neuromedin U | NMUR1 | NMU1 | Human | Neuromedin S-36 | 3 | Peptide | ||||||||
| A (Rhodopsin) | Apelin | APJ | apelin | Human | Apelin Receptor Early Endogenous Ligand | Peptide | |||||||||
| A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Mouse | [Des-Arg9]Bradykinin | 1 | Peptide | 5.7 | 9.2 | 9.2 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Human | Pge2 | Principal | Small molecule | 9.4 | 9.4 | 9.0 | 9.0 | Refs | |||
| A (Rhodopsin) | Acetylcholine receptors (muscarinic) | ACM4 | M4 | Human | Acetylcholine | None | Small molecule | 4.5 | 5.1 | 5.6 | Refs | ||||
| A (Rhodopsin) | Histamine | HRH3 | H3 | Human | Histamine | None | Small molecule | 7.2 | 7.6 | 7.9 | Refs | ||||
| A (Rhodopsin) | Opioid | OPRK | κ | Human | Dynorphin A-(1-8) | 6 | Peptide | 8.0 | 9.0 | 9.9 | Refs | ||||
| A (Rhodopsin) | Kisspeptin | KISSR | kisspeptin | Human | Kisspeptin-52 | 5 | Peptide | ||||||||
| A (Rhodopsin) | Neurotensin | NTR2 | NTS2 | Rat | Neuromedin N | 2 | Peptide | Refs | |||||||
| B1 (Secretin) | Calcitonin | CALCR | CT | Human | Calcitonin | Principal | Peptide | 9.0 | 10.1 | 11.2 | Refs | ||||
| A (Rhodopsin) | Free fatty acid | FFAR2 | FFA2 | Human | Acetic Acid | None | 2 | Small molecule | 3.1 | 3.9 | 4.6 | Refs | |||
| B1 (Secretin) | Parathyroid hormone | PTH2R | PTH2 | Human | Pth | Peptide | |||||||||
| A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Human | Udp-Glucose | None | 1 | Small molecule | 7.7 | 7.7 | Refs | ||||
| A (Rhodopsin) | Adren | ADRB2 | β2-adren | Human | Zn2+ | None | 4 | Small molecule | 3.3 | 4.3 | 5.3 | Refs | |||
| A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Rat | Srif-14 | 4 | Peptide | 7.7 | 8.4 | 9.1 | Refs | ||||
| B1 (Secretin) | Glucagon receptor family | GLP2R | GLP-2 | Rat | Glucagon-Like Peptide 2 | 2 | Peptide | 8.8 | 8.8 | Refs | |||||
| A (Rhodopsin) | Leukotriene | OXER1 | OXE | Human | 5-Oxo-C20:3 | None | 2 | Small molecule | 8.0 | 8.0 | Refs | ||||
| A (Rhodopsin) | Lysophospholipid (LPA) | LPAR2 | LPA2 | Mouse | Lpa | None | 1 | Small molecule | 8.0 | 8.1 | 8.2 | Refs | |||
| A (Rhodopsin) | Opioid | OPRX | NOP | Mouse | Nociceptin/Orphanin Fq | Peptide | 8.4 | 9.1 | 9.8 | 9.7 | 9.4 | 9.4 | Refs | ||
| A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Mouse | Pancreatic Polypeptide | Secondary | Peptide | 10.3 | 10.7 | 10.7 | Refs | ||||
| A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Mouse | Srif-14 | 4 | Peptide | 8.7 | 8.9 | 8.9 | Refs | ||||
| A (Rhodopsin) | Vasopressin and oxytocin | V1AR | V1A | Rat | Oxytocin | Secondary | Peptide | 6.9 | 7.6 | 8.3 | Refs | ||||
| A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Mouse | Srif-14 | 1 | Peptide | 9.0 | 9.1 | 9.1 | 8.9 | 9.7 | 10.5 | Refs | |
| A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Human | Srif-14 | 4 | Peptide | 8.7 | 8.9 | 8.9 | Refs | ||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT2C | 5-HT2C | Human | 5-Hydroxytryptamine | None | Small molecule | 6.7 | 7.3 | 7.9 | Refs | ||||
| A (Rhodopsin) | Apelin | APJ | apelin | Human | Apelin-13 | Peptide | Refs | ||||||||
| A (Rhodopsin) | Prostanoid | TA2R | TP | Human | Pgd2 | Secondary | Small molecule | ||||||||
| A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Rat | Srif-28 | 2 | Peptide | 8.4 | 9.3 | 10.2 | Refs | ||||
| A (Rhodopsin) | Tachykinin | NK3R | NK3 | Mouse | Neurokinin A | 2 | Peptide | 7.4 | 7.4 | 5.5 | 6.1 | 6.1 | Refs | ||
| A (Rhodopsin) | Chemokine | ACKR3 | ACKR3 | Human | Cxcl12Α | 1 | Peptide | 7.5 | 7.7 | 7.9 | Refs | ||||
| A (Rhodopsin) | Orexin | OX2R | OX2 | Human | Orexin-B | 1 | Peptide | 6.5 | 8.3 | 10.0 | Refs | ||||
| A (Rhodopsin) | Adenosine | AA2AR | A2A | Human | Adenosine | None | |||||||||