Data showed in this table is continously collected from the Guide to Pharmacology database. Ref

RECEPTOR ENDOGENOUS LIGANDS pEC50 pKi REFERENCES
Class Receptor family UniProt IUPHAR Species Ligand GtP
Classification
Potency
Ranking
Type Min Mid Max Min Mid Max
A (Rhodopsin) 5-Hydroxytryptamine 5HT1F 5-HT1F Human 5-Hydroxytryptamine Principal 1 Small molecule 7.7 7.9 8.0 Refs
A (Rhodopsin) Chemokine CCR10 CCR10 Human Ccl27 Peptide
A (Rhodopsin) 5-Hydroxytryptamine 5HT2C 5-HT2C Rat 5-Hydroxytryptamine Principal 1 Small molecule 6.8 7.7 8.6 Refs
A (Rhodopsin) Free fatty acid FFAR3 FFA3 Human Butyric Acid None 2 Small molecule 3.8 4.4 4.9 Refs
A (Rhodopsin) Somatostatin SSR1 SST1 Human Srif-14 2 Peptide 8.6 9.1 9.5 Refs
A (Rhodopsin) Adren ADRB3 β3-adren Human (-)-Noradrenaline None 2 Small molecule 4.7 4.2 4.2 Refs
A (Rhodopsin) Leukotriene OXER1 OXE Human 5-Oxo-20-Hete None 6 Small molecule 6.5 6.5 Refs
B1 (Secretin) Glucagon receptor family GHRHR GHRH Human Ghrh Principal 1 Peptide
A (Rhodopsin) Somatostatin SSR5 SST5 Mouse Srif-28 1 Peptide 9.2 9.8 10.3 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Rat Corticotrophin-Releasing Hormone 1 Peptide 7.8 7.8 Refs
A (Rhodopsin) Prostanoid PF2R FP Human Pgf None 1 Small molecule 7.9 8.5 8.5 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR5 S1P5 Rat Sphingosine 1-Phosphate None 1 Small molecule 7.4 8.2 8.9 Refs
A (Rhodopsin) P2Y P2RY4 P2Y4 Human Atp None 2 Small molecule 5.7 5.4 5.4 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Thromboxane A2 6 Small molecule
A (Rhodopsin) Histamine HRH4 H4 Mouse Histamine None 1 Small molecule 7.8 8.1 8.3 Refs
A (Rhodopsin) Prostanoid PD2R DP1 Rat Pgd2 None 2 Small molecule 7.8 7.7 7.7 Refs
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Cxcl6 Peptide
A (Rhodopsin) Proteinase-activated PAR4 PAR4 Human Cathepsin G Peptide
A (Rhodopsin) Somatostatin SSR3 SST3 Mouse Srif-28 2 Peptide 8.1 9.0 9.9 Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Cxcl10 2 Peptide 7.8 8.8 9.8 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Rat Pancreatic Polypeptide 1 Peptide 10.3 10.6 10.8 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Mouse Srif-14 3 Peptide 8.7 8.9 8.9 Refs
A (Rhodopsin) Prokineticin PKR2 PKR2 Human Prokineticin-2Β 3 Peptide Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Rat Srif-14 1 Peptide 9.0 9.1 9.1 8.8 9.2 9.6 Refs
A (Rhodopsin) Opioid OPRM μ Human [Leu]Enkephalin 5 Peptide 8.1 8.1 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl28 5 Peptide
A (Rhodopsin) 5-Hydroxytryptamine 5HT2A 5-HT2A Rat 5-Hydroxytryptamine None 2 Small molecule 6.0 6.3 6.5 Refs
B1 (Secretin) Calcitonin CALCR CT Human Adrenomedullin 5 Peptide 6.7 7.2 7.7 Refs
A (Rhodopsin) Chemokine CXCR4 CXCR4 Human Cxcl12Β 2 Peptide Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Rat Pgd2 None 2 Small molecule 8.8 8.8 8.7 5.9 5.9 Refs
A (Rhodopsin) Galanin GALR2 GAL2 Human Galanin-Like Peptide 4 Peptide
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Cxcl12Α 7 Peptide 6.4 6.4 Refs
A (Rhodopsin) Bombesin GRPR BB2 Human Neuromedin B 1 Peptide 6.4 7.3 8.1 Refs
A (Rhodopsin) Neuropeptide Y NPY2R Y2 Human Pancreatic Polypeptide 5 Peptide
A (Rhodopsin) Bombesin NMBR BB1 Human Grp-(18-27) 2 Peptide
A (Rhodopsin) Histamine HRH3 H3 Rat Histamine Principal 1 Small molecule 7.1 7.5 7.8 Refs
A (Rhodopsin) Galanin GALR2 GAL2 Mouse Galanin 2 Peptide 8.3 8.3 8.3 8.8 9.3 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Pge2 None 1 Small molecule 7.3 7.7 7.7 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Rat Pgf None 3 Small molecule 6.1 6.1 9.1 9.3 9.5 Refs
A (Rhodopsin) Vasopressin and oxytocin V1BR V1B Rat Vasopressin 1 Peptide 9.0 9.9 9.9 Refs
A (Rhodopsin) Chemerin CML1 hemerin Human 18r-Hepe 2 Small molecule
A (Rhodopsin) Lysophospholipid (LPA) LPAR6 LPA6 Mouse Lpa Principal 1 Small molecule 6.0 6.0 Refs
A (Rhodopsin) Orexin OX1R OX1 Human Orexin-A 1 Peptide 6.5 8.4 10.2 Refs
A (Rhodopsin) Opioid OPRD δ Human Β-Endorphin 7 Peptide
A (Rhodopsin) Prostanoid PE2R3 EP3 Human Pge2 None 1 Small molecule 9.4 9.4 9.0 9.0 Refs
A (Rhodopsin) Tachykinin NK2R NK2 Human Neurokinin B 3 Peptide 5.0 6.4 7.7 Refs
C (Glutamate) Metabotropic glutamate GRM6 mGlu6 Human L-Glutamic Acid None 2 Small molecule 4.8 5.0 5.2 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR1 S1P1 Human Sphingosine 1-Phosphate None 1 Small molecule 7.1 8.7 9.5 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1E 5-HT1E Human 5-Hydroxytryptamine None 1 Small molecule 8.0 8.1 8.2 Refs
A (Rhodopsin) Neuromedin U NMUR2 NMU2 Human Neuromedin U-25 2 Peptide 8.4 8.9 9.4 9.6 9.6 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Vip 3 Peptide 7.3 8.3 9.3 7.8 8.4 8.8 Refs
A (Rhodopsin) Proteinase-activated PAR1 PAR1 Human Thrombin Principal 1 Peptide
A (Rhodopsin) Gonadotrophin-releasing hormone GNRHR GnRH1 Human Gnrh I 1 Peptide 7.8 7.9 7.9 7.3 8.0 8.4 Refs
A (Rhodopsin) Chemokine XCR1 XCR1 Human Xcl1 2 Peptide
A (Rhodopsin) Adren ADA2B α2B-adren Human (-)-Adrenaline None 2 Small molecule 5.2 5.2 Refs
A (Rhodopsin) Somatostatin SSR4 SST4 Human Srif-28 3 Peptide 8.1 8.7 9.2 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Human Phi 4 Peptide
F (Frizzled) Frizzled FZD1 FZD1 Human Wnt-1 Peptide
A (Rhodopsin) Dopamine DRD2 D2 Rat Dopamine Principal 1 Small molecule 5.3 5.9 6.4 Refs
A (Rhodopsin) Leukotriene CLTR2 CysLT2 Human Lte4 None 3 Small molecule 5.6 6.3 7.1 6.5 6.5 Refs
A (Rhodopsin) Prostanoid PF2R FP Mouse Pgf None 1 Small molecule 7.9 8.5 8.5 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1F 5-HT1F Rat 5-Hydroxytryptamine Principal 1 Small molecule 7.7 7.9 8.0 Refs
A (Rhodopsin) Prolactin-releasing peptide PRLHR PrRP Human Prrp-20 4 Peptide
A (Rhodopsin) Tachykinin NK1R NK1 Human Neurokinin A 2 Peptide 6.2 7.8 9.3 Refs
C (Glutamate) Metabotropic glutamate GRM4 mGlu4 Rat L-Glutamic Acid None 2 Small molecule 4.7 5.1 5.5 4.9 5.2 5.5 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl26 5 Peptide Refs
A (Rhodopsin) Galanin GALR1 GAL1 Mouse Galanin 1 Peptide 9.8 9.8 9.0 9.6 10.1 Refs
A (Rhodopsin) Class A orphan GPR35 GPR35 Mouse Kynurenic Acid None 2 Small molecule 3.9 5.0 5.0 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR4 LPA4 Mouse Lpa None 1 Small molecule Refs
A (Rhodopsin) Prolactin-releasing peptide PRLHR PrRP Human Pthrp 4 Peptide
A (Rhodopsin) Opioid OPRM μ Human Dynorphin B 2 Peptide 8.5 8.5 Refs
A (Rhodopsin) Class A orphan LGR5 LGR5 Human R-Spondin-4 4 Peptide 9.4 9.4 Refs
B1 (Secretin) Glucagon receptor family GLP1R GLP-1 Human Glucagon 2 Peptide 6.9 7.0 7.0 Refs
A (Rhodopsin) Adenosine AA3R A3 Human Adenosine Principal 1 Small molecule 5.2 5.2 Refs
A (Rhodopsin) Relaxin family peptide RL3R2 RXFP4 Human Insl5 3 Peptide 7.0 7.7 8.9 7.3 8.1 8.8 Refs
B1 (Secretin) Glucagon receptor family GIPR GIP Human Gastric Inhibitory Polypeptide Principal 1 Peptide
A (Rhodopsin) Lysophospholipid (LPA) LPAR5 LPA5 Human Farnesyl Monophosphate None 1 Small molecule 7.3 7.3 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Rat Pyy-(3-36) 6 Peptide 6.2 6.2 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl2 8 Peptide
B2 (Adhesion) ADGRB AGRB1 ADGRB1 Human Phosphatidylserine Principal 1 Small molecule Refs
A (Rhodopsin) Chemokine CCR7 CCR7 Human Ccl19 1 Peptide Refs
A (Rhodopsin) Opioid OPRK κ Human Dynorphin A-(1-8) 5 Peptide 8.0 9.0 9.9 Refs
A (Rhodopsin) Leukotriene CLTR1 CysLT1 Human Ltc4 None 2 Small molecule 7.4 7.6 7.7 7.0 7.6 8.1 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR5 S1P5 Mouse Sphingosine 1-Phosphate None 1 Small molecule 7.4 8.2 8.9 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Rat Srif-14 3 Peptide 8.4 9.2 9.9 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Rat Udp-Glucose None 1 Small molecule 7.6 7.6 Refs
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM1 M1 Human Acetylcholine Principal 1 Small molecule 4.3 5.0 5.0 Refs
B1 (Secretin) Glucagon receptor family SCTR secretin Rat Secretin 2 Peptide 8.0 8.5 9.0 Refs
A (Rhodopsin) Adren ADRB2 β2-adren Human Noradrenaline None 2 Small molecule 5.4 5.4 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Ghrh 4 Peptide
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Pthrp 5 Peptide
A (Rhodopsin) Opioid OPRK κ Rat Dynorphin A-(1-13) 1 Peptide 9.3 10.0 10.7 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Rat Tyramine None 3 Small molecule 6.2 6.7 7.1 6.4 6.4 Refs
A (Rhodopsin) Adren ADA2C α2C-adren Human (-)-Adrenaline None 2 Small molecule 5.8 5.8 Refs
A (Rhodopsin) Bradykinin BKRB2 B2 Human Lys-[Hyp3]-Bradykinin 4 Peptide
A (Rhodopsin) Adren ADA1D α1D-adren Human (-)-Adrenaline None 1 Small molecule 7.2 7.2 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT4R 5-HT4 Human 5-Hydroxytryptamine Principal 1 Small molecule 5.9 6.5 7.0 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Human Pge1 None 1 Small molecule 8.0 8.0 Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Annexin I 9 Peptide Refs
A (Rhodopsin) Chemokine CCR4 CCR4 Human Ccl22 1 Peptide Refs
A (Rhodopsin) Free fatty acid FFAR2 FFA2 Human Acetic Acid None 2 Small molecule 3.1 3.9 4.6 Refs
A (Rhodopsin) Endothelin EDNRB ETB Human Endothelin-2 2 Peptide
A (Rhodopsin) Histamine HRH3 H3 Human Histamine Principal 1 Small molecule 7.1 7.5 7.8 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Mouse Pge1 None 1 Small molecule 9.5 9.5 8.7 8.7 Refs
A (Rhodopsin) Vasopressin and oxytocin V1BR V1B Human Vasopressin 1 Peptide 9.0 9.9 9.9 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl3 5 Peptide 8.0 8.5 8.9 Refs
A (Rhodopsin) Bradykinin BKRB2 B2 Human Bradykinin 2 Peptide Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Rat Srif-14 3 Peptide 8.7 8.9 8.9 Refs
A (Rhodopsin) Endothelin EDNRA ETA Human Endothelin-3 3 Peptide
A (Rhodopsin) Somatostatin SSR3 SST3 Human Srif-14 3 Peptide 8.7 8.9 8.9 Refs
A (Rhodopsin) Melatonin MTR1B MT2 Human Melatonin Principal 1 Small molecule 9.4 9.6 9.8 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Rat Galanin 2 Peptide 8.1 8.5 8.8 Refs
A (Rhodopsin) Prostanoid PD2R DP1 Human Pgj2 None 1 Small molecule 9.0 9.0 Refs
A (Rhodopsin) Free fatty acid FFAR4 FFA4 Human Α-Linolenic Acid None 3 Small molecule 5.1 5.1 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Rfrp-3 2 Peptide 7.8 7.8 Refs
A (Rhodopsin) Opioid OPRK κ Mouse Dynorphin A 2 Peptide 8.3 9.6 10.8 Refs
A (Rhodopsin) Orexin OX1R OX1 Human Orexin-B 3 Peptide
A (Rhodopsin) Neurotensin NTR1 NTS1 Rat Neurotensin 1 Peptide 8.3 9.0 9.7 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Secretin 4 Peptide
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Neuropeptide Ff 2 Peptide 8.5 9.2 9.9 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR3 LPA3 Mouse Lpa None 1 Small molecule 6.6 6.6 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl5 3 Peptide
A (Rhodopsin) Lysophospholipid (S1P) S1PR3 S1P3 Mouse Sphingosine 1-Phosphate None 1 Small molecule 8.4 9.1 9.8 Refs
A (Rhodopsin) Neuromedin U NMUR2 NMU2 Human Neuromedin S-33 1 Peptide 10.0 10.0 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Human Pgf None 3 Small molecule 5.2 5.6 6.0 Refs
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Tip39 1 Peptide Refs
A (Rhodopsin) Galanin GALR1 GAL1 Rat Galanin 1 Peptide 9.8 9.8 9.0 9.6 10.1 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1D 5-HT1D Human 5-Hydroxytryptamine None 1 Small molecule 8.0 8.5 9.0 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl13 2 Peptide Refs
A (Rhodopsin) Class A orphan GPR37 GPR37 Human Prosaptide Principal 1 Peptide 8.1 8.1 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Human Srif-14 3 Peptide 8.4 9.2 9.9 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Human Pgj2 None 3 Small molecule 7.3 7.3 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Human Urocortin 1 2 Peptide Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Agouti-Related Protein 2 Peptide Refs
A (Rhodopsin) Neuropeptide Y Q9ERC0 Y2 Rat Peptide Yy 1 Peptide 10.0 10.0 Refs
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Cathepsin G 2 Peptide
A (Rhodopsin) Melanin-concentrating hormon MCHR1 MCH1 Human Melanin-Concentrating Hormone Principal 1 Peptide 9.8 9.9 10.0 Refs
A (Rhodopsin) Opioid OPRK κ Human Β-Endorphin 9 Peptide
A (Rhodopsin) P2Y P2Y14 P2Y14 Mouse Udp-Glucose None 1 Small molecule 7.6 7.6 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Pgf None 3 Small molecule 6.2 6.4 6.4 Refs
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C3a 2 Peptide
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl8 5 Peptide
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Rat Oxytocin 2 Peptide 6.9 7.6 8.3 Refs
A (Rhodopsin) Neuromedin U NMUR1 NMU1 Human Neuromedin U-23 3 Peptide
A (Rhodopsin) Galanin GALR1 GAL1 Human Galanin 2 Peptide 9.1 9.8 10.5 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Rat Vip 3 Peptide 7.3 8.3 9.3 7.8 8.4 8.8 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT4R 5-HT4 Mouse 5-Hydroxytryptamine Principal 1 Small molecule 5.9 6.5 7.0 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl3 1 Peptide 7.8 9.0 10.2 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Mouse Pgd2 None 1 Small molecule 7.6 8.1 8.6 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide W-30 5 Peptide
A (Rhodopsin) Class A orphan GPR34 GPR34 Mouse Lysophosphatidylserine Principal 1 Small molecule 6.6 7.3 7.3 Refs
A (Rhodopsin) Histamine HRH1 H1 Human Histamine Principal 1 Small molecule 4.7 5.3 5.9 Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Humanin 4 Peptide 8.5 8.5 Refs
A (Rhodopsin) Somatostatin SSR1 SST1 Human Cortistatin-14 4 Peptide
A (Rhodopsin) Adren ADRB1 β1-adren Human (-)-Adrenaline None 3 Small molecule 5.4 5.7 6.0 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Secretin 4 Peptide
A (Rhodopsin) Somatostatin SSR2 SST2 Human Cst-17 2 Peptide 8.8 9.1 9.3 Refs
B1 (Secretin) Calcitonin CALCR CT Human Calcitonin 1 Peptide 9.0 10.1 11.2 Refs
A (Rhodopsin) Vasopressin and oxytocin V2R V2 Human Vasopressin 1 Peptide 7.9 8.5 9.1 Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Γ-Msh 2 Peptide
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Human Peptide Yy 5 Peptide 6.3 7.0 8.5 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Mouse Pgd2 None 3 Small molecule 7.9 7.9 5.9 7.4 8.9 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT5A 5-HT5A Rat 5-Hydroxytryptamine Principal 1 Small molecule 6.0 6.3 6.6 Refs
A (Rhodopsin) Somatostatin SSR4 SST4 Human Srif-14 2 Peptide 8.4 8.9 9.3 Refs
A (Rhodopsin) Opioid OPRK κ Rat Dynorphin A 2 Peptide 8.3 9.6 10.8 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Human Srif-28 2 Peptide 8.1 9.0 9.9 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR3 S1P3 Human Sphingosine 1-Phosphate None 1 Small molecule 8.4 9.1 9.8 Refs
A (Rhodopsin) Bile acid GPBAR GPBA Human Deoxycholic Acid None 2 Small molecule 6.2 6.2 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Mouse Pge1 None 1 Small molecule 9.4 9.4 9.0 9.0 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR2 LPA2 Human Lpa None 1 Small molecule 6.7 7.5 8.2 Refs
A (Rhodopsin) Adren ADA1D α1D-adren Human (-)-Noradrenaline None 2 Small molecule 6.3 6.3 Refs
A (Rhodopsin) Dopamine DRD1 D1 Human 5-Hydroxytryptamine None 1 Small molecule 5.0 5.0 Refs
B1 (Secretin) Parathyroid hormone PTH1R PTH1 Human Pth 3 Peptide
A (Rhodopsin) Chemokine ACKR3 ACKR3 Human Cxcl12Α 1 Peptide 7.5 7.7 7.9 Refs
A (Rhodopsin) Chemokine CCR8 CCR8 Mouse Ccl8 2 Peptide
A (Rhodopsin) Lysophospholipid (S1P) S1PR4 S1P4 Human Sphingosine 1-Phosphate None 1 Small molecule 7.2 7.1 7.1 Refs
A (Rhodopsin) Neurotensin NTR2 NTS2 Human Neurotensin 1 Peptide 8.8 8.8 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Human Galanin 2 Peptide 8.1 8.5 8.8 Refs
A (Rhodopsin) Chemokine CCR4 CCR4 Human Ccl22 3 Peptide
B1 (Secretin) VIP and PACAP PACR PAC1 Human Phm 4 Peptide
A (Rhodopsin) Adren ADRB3 β3-adren Mouse (&Plusmn;)-Adrenaline None 1 Small molecule 3.9 5.3 5.3 Refs
A (Rhodopsin) Proteinase-activated PAR4 PAR4 Human Thrombin Peptide
A (Rhodopsin) Adren ADA1A α1A-adren Human (-)-Adrenaline None 1 Small molecule 6.3 6.4 6.5 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Mouse Pgf None 3 Small molecule 6.2 6.4 6.4 Refs
A (Rhodopsin) Histamine HRH4 H4 Rat Histamine None 1 Small molecule 7.8 8.1 8.3 Refs
A (Rhodopsin) Neurotensin NTR2 NTS2 Mouse Xenin 2 Peptide Refs
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Ccl5 Peptide
A (Rhodopsin) Prostanoid PE2R1 EP1 Rat Pgf None 3 Small molecule 6.2 6.4 6.4 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Mouse Srif-14 3 Peptide 8.4 9.2 9.9 Refs
A (Rhodopsin) Dopamine DRD3 D3 Human Dopamine Principal 1 Small molecule 6.4 6.9 7.3 Refs
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM2 M2 Human Acetylcholine Principal 1 Small molecule 4.3 5.4 6.5 Refs
A (Rhodopsin) Glycoprotein hormone TSHR TSH Human Tsh Principal 1 Peptide
A (Rhodopsin) Bombesin NMBR BB1 Human Neuromedin B 1 Peptide 8.1 9.2 10.3 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Rat Galanin-Like Peptide 2 Peptide Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT5A 5-HT5A Human 5-Hydroxytryptamine Principal 1 Small molecule 6.0 6.3 6.6 Refs
A (Rhodopsin) Endothelin EDNRB ETB Human Endothelin-3 1 Peptide Refs
A (Rhodopsin) Free fatty acid FFAR4 FFA4 Human Myristic Acid None 2 Small molecule 5.2 5.2 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Pgf None 3 Small molecule 6.1 6.1 9.1 9.3 9.5 Refs
C (Glutamate) Metabotropic glutamate GRM4 mGlu4 Rat L-Serine-O-Phosphate None 1 Small molecule 5.9 5.9 Refs
C (Glutamate) Metabotropic glutamate GRM2 mGlu2 Rat L-Glutamic Acid Principal 1 Small molecule 4.7 5.1 5.4 5.4 5.7 5.9 Refs
A (Rhodopsin) Leukotriene LT4R1 BLT1 Human 12r-Hete None 3 Small molecule 7.5 7.5 Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Β-Msh 2 Peptide
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Human Corticotrophin-Releasing Hormone 1 Peptide 7.8 7.8 Refs
A (Rhodopsin) Orexin OX1R OX1 Human Orexin-B 2 Peptide 5.8 7.5 9.2 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Pacap-27 2 Peptide 7.6 8.6 9.9 8.9 8.9 Refs
A (Rhodopsin) Adren ADA1A α1A-adren Human (-)-Noradrenaline None 2 Small molecule 5.8 6.1 6.4 Refs
C (Glutamate) Metabotropic glutamate GRM7 mGlu7 Human L-Serine-O-Phosphate None 1 Small molecule 4.5 4.5 4.4 4.4 Refs
A (Rhodopsin) Tachykinin NK3R NK3 Mouse Neurokinin A 2 Peptide 7.4 7.4 5.5 5.9 6.3 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl13 4 Peptide 9.1 9.1 Refs
A (Rhodopsin) Vasopressin and oxytocin V1BR V1B Human Oxytocin 2 Peptide 5.7 6.4 7.0 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Human Tyramine None 3 Small molecule 6.2 6.7 7.1 6.4 6.4 Refs
B1 (Secretin) Calcitonin CALCR CT Human Amylin 3 Peptide 8.0 8.6 9.2 Refs
C (Glutamate) Metabotropic glutamate GRM1 mGlu1 Human L-Glutamic Acid Principal 1 Small molecule 4.8 4.9 5.0 6.4 6.5 6.5 Refs
A (Rhodopsin) Tachykinin NK3R NK3 Mouse Neurokinin B 1 Peptide 8.4 8.4 7.7 8.5 9.2 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Mouse Β-Phenylethylamine None 2 Small molecule 6.3 6.9 7.4 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Human Vip 3 Peptide 6.0 7.0 8.7 5.5 5.7 5.8 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT4R 5-HT4 Rat 5-Hydroxytryptamine Principal 1 Small molecule 5.9 6.5 7.0