Data showed in this table is continously collected from the Guide to Pharmacology database. Ref

RECEPTOR ENDOGENOUS LIGANDS pEC50 pKi REFERENCES
Class Receptor family UniProt IUPHAR Species Ligand GtP
Classification		 Potency
Ranking		 Type Smiles Inchikey Min Mid Max Min Mid Max
A (Rhodopsin) Trace amine TAAR1 TA1 Mouse Β-Phenylethylamine None 2 Small molecule NCCc1ccccc1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 6.2 6.6 7.0 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Human Pge1 None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O GMVPRGQOIOIIMI-DWKJAMRDSA-N 9.4 9.4 9.0 9.0 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Mouse Srif-28 2 Peptide - GGYTXJNZMFRSLX-DFTNLTQTSA-N 8.4 8.8 8.8 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Human Udp-Glucose None 1 Small molecule OC[C@H]1O[C@H](OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2ccc(=O)[nH]c2=O)O)O)[C@@H]([C@H]([C@@H]1O)O)O HSCJRCZFDFQWRP-JZMIEXBBSA-N 7.7 7.7 Refs
A (Rhodopsin) Ghrelin GHSR ghrelin Human [Des-Gln14]Ghrelin 2 Peptide - -
A (Rhodopsin) Somatostatin SSR1 SST1 Human Cst-17 1 Peptide - - 9.1 9.4 9.6 Refs
A (Rhodopsin) Proteinase-activated PAR3 PAR3 Human Thrombin Principal 1 Peptide - -
A (Rhodopsin) Opioid OPRK κ Human Β-Endorphin 9 Peptide - KSZMZNRVPCEDEO-KFHPFRHLSA-N
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Human Peptide Yy 2 Peptide - IXMRLEGHWROJAA-HDTKZREISA-N 9.0 9.0 Refs
A (Rhodopsin) Melanocortin MC3R MC3 Human Acth 3 Peptide - -
A (Rhodopsin) Melanocortin MSHR MC1 Human Α-Msh 2 Peptide - - Refs
A (Rhodopsin) Chemokine CCRL2 CCRL2 Human Chemerin C-Terminal Peptide 2 Peptide - QLVGSBXIQFERFK-NBBYSTNSSA-N
A (Rhodopsin) Somatostatin SSR3 SST3 Rat Srif-14 1 Peptide - VVEJUSYNERNRME-XGFVQVCISA-N 8.7 9.4 10.0 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Human Cortistatin-14 2 Peptide - -
A (Rhodopsin) Prostanoid PE2R3 EP3 Mouse Pgf2Α None 2 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O PXGPLTODNUVGFL-YNNPMVKQSA-N 8.4 8.4 7.1 7.1 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR3 LPA3 Human Farnesyl Monophosphate None 2 Small molecule C/C(=C/CC/C(=C\COP(=O)(O)O)/C)/CCC=C(C)C ALEWCKXBHSDCCT-FBXUGWQNSA-N Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT2B 5-HT2B Human 5-Hydroxytryptamine Principal 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 7.9 8.0 8.0 Refs
A (Rhodopsin) Galanin GALR1 GAL1 Mouse Galanin 1 Peptide - - 9.8 9.8 9.3 9.8 10.3 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl3 3 Peptide - -
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Pacap-27 2 Peptide - RZGBUJXSKLDAFE-UHFFFAOYSA-N 7.6 8.6 9.9 8.9 8.9 Refs
A (Rhodopsin) Bombesin GRPR BB2 Human Neuromedin B 2 Peptide - YPFNACALNKVZNK-UHFFFAOYSA-N 6.6 7.0 7.4 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Mouse Srif-28 1 Peptide - GGYTXJNZMFRSLX-DFTNLTQTSA-N 9.2 9.8 10.3 Refs
A (Rhodopsin) Relaxin family peptide RL3R1 RXFP3 Human Relaxin-3 1 Peptide - - 8.3 9.1 9.9 7.8 8.4 8.9 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Rat Vip 3 Peptide - VBUWHHLIZKOSMS-UHFFFAOYSA-N 6.0 7.0 8.7 6.0 6.9 8.4 Refs
A (Rhodopsin) Opioid OPRK κ Rat Dynorphin A 1 Peptide - JMNJYGMAUMANNW-FIXZTSJVSA-N 10.0 10.2 10.3 Refs
F (Frizzled) Frizzled FZD1 FZD1 Human Wnt-5a Peptide - -
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl5 Peptide - -
A (Rhodopsin) Neurotensin NTR1 NTS1 Human Neuromedin N 3 Peptide - -
A (Rhodopsin) Vasopressin and oxytocin V1BR V1B Rat Vasopressin 1 Peptide - KBZOIRJILGZLEJ-LGYYRGKSSA-N 9.0 9.9 9.9 Refs
A (Rhodopsin) Bradykinin BKRB2 B2 Human Bradykinin 1 Peptide - QXZGBUJJYSLZLT-FDISYFBBSA-N Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Mouse Srif-14 3 Peptide - VVEJUSYNERNRME-XGFVQVCISA-N 8.4 9.2 9.9 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Mouse Srif-14 1 Peptide - VVEJUSYNERNRME-XGFVQVCISA-N 8.7 9.4 10.0 Refs
A (Rhodopsin) Leukotriene OXER1 OXE Human 5-Oxo-20-Hete None 6 Small molecule OCCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O DTSRZRUIWKDHMR-DHYYJNSCSA-N 6.5 6.5 Refs
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM1 M1 Rat Acetylcholine Principal 1 Small molecule CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 4.3 4.6 4.9 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Mouse Tyramine None 3 Small molecule NCCc1ccc(cc1)O DZGWFCGJZKJUFP-UHFFFAOYSA-N 5.8 6.3 6.7 6.4 6.4 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Mouse Pge2 None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O XEYBRNLFEZDVAW-ARSRFYASSA-N 7.3 7.7 7.7 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1E 5-HT1E Human 5-Hydroxytryptamine None 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 8.0 8.1 8.2 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Human Pgd2 None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O BHMBVRSPMRCCGG-OUTUXVNYSA-N 7.4 7.5 7.5 Refs
A (Rhodopsin) Chemokine CXCR5 CXCR5 Human Cxcl13 Principal 1 Peptide - -
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl2 4 Peptide - - 7.2 7.5 7.8 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Mouse Pgd2 None 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O BHMBVRSPMRCCGG-OUTUXVNYSA-N 7.9 7.9 5.9 7.4 8.9 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Rat Vip 3 Peptide - VBUWHHLIZKOSMS-UHFFFAOYSA-N 7.3 8.3 9.3 7.8 8.4 8.8 Refs
A (Rhodopsin) Neurotensin NTR2 NTS2 Rat Neurotensin 1 Peptide - PCJGZPGTCUMMOT-ISULXFBGSA-N 8.8 8.8 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Rat Peptide Yy 5 Peptide - IXMRLEGHWROJAA-HDTKZREISA-N 6.3 7.0 8.5 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT2C 5-HT2C Rat 5-Hydroxytryptamine Principal 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 6.8 7.7 8.6 Refs
A (Rhodopsin) Opioid OPRD δ Human Dynorphin A-(1-8) 2 Peptide - WRPLGMBDXVBPEG-VGXZEHLRSA-N 8.4 8.4 Refs
A (Rhodopsin) Bombesin GRPR BB2 Mouse Neuromedin B 2 Peptide - YPFNACALNKVZNK-UHFFFAOYSA-N 6.6 7.0 7.4 Refs
A (Rhodopsin) Leukotriene LT4R2 BLT2 Human 12-Epi Ltb4 None 2 Small molecule CCCCC/C=C\C[C@@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O VNYSSYRCGWBHLG-CBBLYLIKSA-N 7.5 7.5 Refs
A (Rhodopsin) Motilin MTLR motilin Human Motilin Principal 1 Peptide - LVRVABPNVHYXRT-BQWXUCBYSA-N 8.4 8.6 8.7 Refs
A (Rhodopsin) Adren ADA1A α1A Human (-)-Adrenaline None 1 Small molecule CNC[C@@H](c1ccc(c(c1)O)O)O UCTWMZQNUQWSLP-VIFPVBQESA-N 5.6 7.4 9.1 5.1 5.8 6.5 Refs
A (Rhodopsin) GPR18, GPR55 and GPR119 GPR55 GPR55 Human Lysophosphatidylinositol None 4 Small molecule O[C@@H](COC(=O)C)COP(=O)(O[C@@H]1[C@H](O)[C@H](O)[C@H]([C@@H]([C@H]1O)O)O)O FBDBXJJQMHPGMP-IFUOQLDVSA-N 5.5 6.4 7.3 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR5 S1P5 Human Sphingosine 1-Phosphate None 1 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O DUYSYHSSBDVJSM-KRWOKUGFSA-N 7.8 7.9 7.9 Refs
A (Rhodopsin) Somatostatin SSR1 SST1 Rat Srif-14 2 Peptide - VVEJUSYNERNRME-XGFVQVCISA-N 8.6 9.1 9.5 Refs
A (Rhodopsin) Chemerin CML1 chemerin Human Resolvin E1 None 2 Small molecule CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O AOPOCGPBAIARAV-OTBJXLELSA-N Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Pgf2Α None 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O PXGPLTODNUVGFL-YNNPMVKQSA-N 6.2 6.3 6.3 Refs
A (Rhodopsin) Opioid OPRD δ Human [Met]Enkephalin 7 Peptide - YFGBQHOOROIVKG-FKBYEOEOSA-N Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Human Cst-17 2 Peptide - - 8.5 9.4 10.2 Refs
A (Rhodopsin) Galanin GALR2 GAL2 Rat Galanin 2 Peptide - - 8.3 8.3 8.3 8.8 9.3 Refs
A (Rhodopsin) Class A orphan GP183 GPR183 Human 7Α,27-Dihydroxycholesterol None 2 Small molecule OC[C@@H](CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@H](O)C=C2[C@]1(C)CC[C@@H](C2)O)C)C RXMHNAKZMGJANZ-GNENNHQYSA-N 8.9 8.9 Refs
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Cxcl5 Peptide - -
A (Rhodopsin) Somatostatin SSR2 SST2 Human Srif-28 2 Peptide - GGYTXJNZMFRSLX-DFTNLTQTSA-N 8.4 8.8 8.8 Refs
A (Rhodopsin) Tachykinin NK2R NK2 Human Neurokinin B 3 Peptide - NHXYSAFTNPANFK-HDMCBQFHSA-N 5.0 6.4 7.7 Refs
A (Rhodopsin) Neuropeptide Y Q9ERC0 Y2 Rat Neuropeptide Y 4 Peptide - XKWCTHKJQNUFOQ-HRPSIEBRSA-N 9.3 9.4 9.4 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Human Peptide Yy 3 Peptide - - 8.8 8.8 Refs
A (Rhodopsin) Urotensin UR2R UT Human Urotensin-Ii 2 Peptide - - 8.6 8.6 Refs
A (Rhodopsin) Apelin APJ apelin Human Elabela/Toddler-11 2 Peptide - XXKPNJFJXZBRMX-HDKAIKTRSA-N
C (Glutamate) Metabotropic glutamate GRM4 mGlu4 Rat L-Glutamic Acid None 2 Small molecule OC(=O)CC[C@@H](C(=O)O)N WHUUTDBJXJRKMK-VKHMYHEASA-N 4.7 5.1 5.5 4.9 5.2 5.5 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT2C 5-HT2C Human 5-Hydroxytryptamine Principal 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 6.8 7.7 8.6 Refs
A (Rhodopsin) Hydroxycarboxylic acid HCAR1 HCA1 Human L-Lactic Acid Principal 1 Small molecule OC(=O)[C@@H](O)C JVTAAEKCZFNVCJ-REOHCLBHSA-N 1.3 2.1 2.9 Refs
A (Rhodopsin) Vasopressin and oxytocin V1BR V1B Human Vasopressin 1 Peptide - KBZOIRJILGZLEJ-LGYYRGKSSA-N 9.0 9.9 9.9 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR1 S1P1 Human Sphingosine 1-Phosphate None 1 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O DUYSYHSSBDVJSM-KRWOKUGFSA-N 7.1 8.7 9.5 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Vip 3 Peptide - VBUWHHLIZKOSMS-UHFFFAOYSA-N 7.3 8.3 9.3 7.8 8.4 8.8 Refs
A (Rhodopsin) Chemokine CCR8 CCR8 Human Ccl1 2 Peptide - -
A (Rhodopsin) Adren ADA2A α2A Human (-)-Noradrenaline None 2 Small molecule NC[C@@H](c1ccc(c(c1)O)O)O SFLSHLFXELFNJZ-QMMMGPOBSA-N 5.3 6.6 7.7 3.6 5.5 7.4 Refs
A (Rhodopsin) Leukotriene CLTR2 CysLT2 Human Ltd4 None 2 Small molecule CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N YEESKJGWJFYOOK-LDDGIIIKSA-N 6.8 7.6 8.6 7.3 7.7 8.1 Refs
A (Rhodopsin) Opioid OPRD δ Human [Leu]Enkephalin 1 Peptide - URLZCHNOLZSCCA-UHFFFAOYSA-N 8.7 8.7 Refs
A (Rhodopsin) Adren ADRB3 β3 Mouse (&Plusmn;)-Adrenaline None 3 Small molecule CNCC(c1ccc(c(c1)O)O)O UCTWMZQNUQWSLP-UHFFFAOYSA-N 3.9 5.3 5.3 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Human Srif-14 1 Peptide - VVEJUSYNERNRME-XGFVQVCISA-N 9.0 9.1 9.1 8.9 8.8 8.8 Refs
A (Rhodopsin) Opioid OPRK κ Human Β-Endorphin 7 Peptide - JMHFFDIMOUKDCZ-NTXHZHDSSA-N 6.3 7.1 7.9 Refs
A (Rhodopsin) Adren ADRB1 β1 Human (-)-Noradrenaline None 1 Small molecule NC[C@@H](c1ccc(c(c1)O)O)O SFLSHLFXELFNJZ-QMMMGPOBSA-N 7.9 7.9 5.5 5.8 6.0 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Mouse Pgf2Α None 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O PXGPLTODNUVGFL-YNNPMVKQSA-N 6.2 6.3 6.3 Refs
A (Rhodopsin) Adren ADRB2 β2 Human (-)-Adrenaline None 1 Small molecule CNC[C@@H](c1ccc(c(c1)O)O)O UCTWMZQNUQWSLP-VIFPVBQESA-N 7.9 7.9 6.0 6.1 6.2 Refs
A (Rhodopsin) Estrogen (G protein-coupled) GPER1 GPER Human 17Β-Estradiol Principal 1 Small molecule Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C VOXZDWNPVJITMN-ZBRFXRBCSA-N 8.2 8.4 8.5 Refs
C (Glutamate) Class C Orphan GPC6A GPRC6 Human L-Alanine None 3 Small molecule C[C@@H](C(=O)O)N QNAYBMKLOCPYGJ-REOHCLBHSA-N 3.8 3.8 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR2 S1P2 Human Sphingosine 1-Phosphate None 1 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O DUYSYHSSBDVJSM-KRWOKUGFSA-N 8.1 8.3 8.5 Refs
A (Rhodopsin) Neuropeptide Y NPY1R Y1 Human Neuropeptide Y 1 Peptide - XKWCTHKJQNUFOQ-HRPSIEBRSA-N 10.5 10.5 Refs
B1 (Secretin) Calcitonin CALCR CT Human Calcitonin (Salmon) None 2 Peptide - AZCMZZXDDMAXIT-VJVYQDLKSA-N 7.6 9.4 11.1 Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Cxcl11 1 Peptide - - 10.4 10.5 10.5 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Mouse Pge2 None 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O XEYBRNLFEZDVAW-ARSRFYASSA-N 6.1 6.1 8.1 8.6 9.1 Refs
A (Rhodopsin) Histamine HRH3 H3 Rat Histamine Principal 1 Small molecule NCCc1cnc[nH]1 NTYJJOPFIAHURM-UHFFFAOYSA-N 7.1 7.5 7.8 Refs
A (Rhodopsin) Proteinase-activated PAR4 PAR4 Human Thrombin Peptide - -
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide B-29 5 Peptide - -
A (Rhodopsin) Chemokine ACKR3 ACKR3 Human Cxcl11 3 Peptide - -
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Fmet-Leu-Phe None 1 Peptide - PRQROPMIIGLWRP-BZSNNMDCSA-N 10.1 10.2 10.2 Refs
A (Rhodopsin) Neuromedin U NMUR1 NMU1 Human Neuromedin S-33 1 Peptide - - 10.2 10.2 Refs
A (Rhodopsin) Melanocortin ACTHR MC2 Mouse Acth Principal 1 Peptide - - Refs
A (Rhodopsin) Gonadotrophin-releasing hormone GNRHR GnRH1 Human Gnrh I 1 Peptide - NMJREATYWWNIKX-UHFFFAOYSA-N 7.8 10.0 10.0 7.3 6.8 6.8 Refs
A (Rhodopsin) Chemokine CXCR4 CXCR4 Human Cxcl12Α 1 Peptide - - Refs
A (Rhodopsin) Chemokine CXCR6 CXCR6 Human Cxcl16 Principal 1 Peptide - -
A (Rhodopsin) Class A orphan LGR6 LGR6 Human R-Spondin-4 Peptide - - Refs
A (Rhodopsin) Chemokine CXCR1 CXCR1 Human Cytokine Domain Of Tyrosyl Trna Synthetase 3 Peptide - -
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C5a 2 Peptide - -
A (Rhodopsin) Adren ADRB3 β3 Rat (+)-Adrenaline None 3 Small molecule CNC[C@H](c1ccc(c(c1)O)O)O UCTWMZQNUQWSLP-SECBINFHSA-N
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Rat Vip 1 Peptide - VBUWHHLIZKOSMS-UHFFFAOYSA-N 7.9 9.0 10.0 8.5 9.2 9.8 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Human Β-Phenylethylamine None 2 Small molecule NCCc1ccccc1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 6.2 6.6 7.0 Refs
A (Rhodopsin) Orexin OX1R OX1 Human Orexin-B 2 Peptide - OHOWSYIKESXDMN-WMQZXSDYSA-N 5.8 7.5 9.2 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl8 1 Peptide - - 8.8 9.2 9.5 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Human Pgi2 6 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O KAQKFAOMNZTLHT-OZUDYXHBSA-N
A (Rhodopsin) Bradykinin BKRB1 B1 Mouse [Des-Arg9]Bradykinin 2 Peptide - VCEHWDBVPZFHAG-UHFFFAOYSA-N 5.7 9.2 9.2 Refs
A (Rhodopsin) GPR18, GPR55 and GPR119 GPR55 GPR55 Human N-Palmitoylethanolamine None 2 Small molecule CCCCCCCCCCCCCCCC(=O)NCCO HXYVTAGFYLMHSO-UHFFFAOYSA-N 8.4 8.4 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Human Pge2 None 2 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O XEYBRNLFEZDVAW-ARSRFYASSA-N 7.5 7.9 8.3 Refs
A (Rhodopsin) P2Y P2RY6 P2Y6 Human Adp None 3 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N XTWYTFMLZFPYCI-KQYNXXCUSA-N 4.5 4.5 Refs
A (Rhodopsin) Free fatty acid FFAR3 FFA3 Human Propanoic Acid None 1 Small molecule CCC(=O)O XBDQKXXYIPTUBI-UHFFFAOYSA-N 3.9 4.8 5.7 Refs
A (Rhodopsin) Histamine HRH3 H3 Human Histamine Principal 1 Small molecule NCCc1cnc[nH]1 NTYJJOPFIAHURM-UHFFFAOYSA-N 7.1 7.5 7.8 Refs
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Cxcl11 Peptide - -
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl5 2 Peptide - - 9.2 9.5 9.7 Refs
A (Rhodopsin) Prostanoid TA2R TP Human Pgd2 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O BHMBVRSPMRCCGG-OUTUXVNYSA-N
A (Rhodopsin) Leukotriene OXER1 OXE Human 5-Oxo-Ete None 1 Small molecule CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O MEASLHGILYBXFO-XTDASVJISA-N 8.3 8.4 8.5 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Human Galanin 2 Peptide - - 8.1 8.5 8.8 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl13 5 Peptide - - Refs
A (Rhodopsin) P2Y P2Y11 P2Y11 Human Atp None 2 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N ZKHQWZAMYRWXGA-KQYNXXCUSA-N 4.2 4.9 5.6 Refs
A (Rhodopsin) Galanin GALR1 GAL1 Rat Galanin 1 Peptide - - 9.8 9.8 9.3 9.8 10.3 Refs
A (Rhodopsin) Histamine HRH4 H4 Human Histamine None 1 Small molecule NCCc1cnc[nH]1 NTYJJOPFIAHURM-UHFFFAOYSA-N 7.8 7.4 7.4 Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Ccl5 7 Peptide - - 6.4 6.4 Refs
A (Rhodopsin) Melanocortin MC3R MC3 Human Α-Msh 1 Peptide - - 8.0 8.2 8.4 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Rat Pgf2Α None 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O PXGPLTODNUVGFL-YNNPMVKQSA-N 5.2 5.6 6.0 Refs
A (Rhodopsin) Prostanoid PI2R IP Mouse Pge1 None 2 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O GMVPRGQOIOIIMI-DWKJAMRDSA-N 6.5 7.5 7.5 Refs
A (Rhodopsin) Adren ADRB3 β3 Rat (&Plusmn;)-Adrenaline None 3 Small molecule CNCC(c1ccc(c(c1)O)O)O UCTWMZQNUQWSLP-UHFFFAOYSA-N 3.9 5.3 5.3 Refs
A (Rhodopsin) Leukotriene LT4R2 BLT2 Human 12-Hydroxyheptadecatrienoic Acid None 1 Small molecule CCCCC[C@@H](/C=C/C=C/C/C=C\CCCC(=O)O)O KUKJHGXXZWHSBG-WBGSEQOASA-N 7.7 7.7 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Human Peptide Yy 5 Peptide - IXMRLEGHWROJAA-HDTKZREISA-N 6.3 7.0 8.5 Refs
A (Rhodopsin) Opioid OPRK κ Human Dynorphin A-(1-8) 6 Peptide - WRPLGMBDXVBPEG-VGXZEHLRSA-N 8.0 9.0 9.9 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Mouse Udp-Glucuronic Acid None 4 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(O[C@H]2O[C@H](C(=O)O)[C@H]([C@@H]([C@H]2O)O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O HDYANYHVCAPMJV-LXQIFKJMSA-N 7.0 7.0 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide W-23 2 Peptide - - Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl13 4 Peptide - - 9.1 9.1 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT4R 5-HT4 Rat 5-Hydroxytryptamine Principal 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 5.9 7.2 7.2 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT5B 5HT5B Mouse 5-Hydroxytryptamine Principal 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Rat Vasopressin 1 Peptide - KBZOIRJILGZLEJ-LGYYRGKSSA-N 8.5 8.9 9.3 Refs
A (Rhodopsin) Prostanoid PD2R DP1 Human Pge1 None 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O GMVPRGQOIOIIMI-DWKJAMRDSA-N 7.3 7.3 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Rat Pge1 None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O GMVPRGQOIOIIMI-DWKJAMRDSA-N 8.0 8.0 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Human [Des-Arg10]Kallidin 1 Peptide - AILVBOHFGXNHCC-TZPCGENMSA-N 9.6 9.8 10.0 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl5 3 Peptide - -
A (Rhodopsin) Adenosine AA1R A1 Rat Adenosine Principal 1 Small molecule OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N OIRDTQYFTABQOQ-KQYNXXCUSA-N 7.0 7.0 Refs
C (Glutamate) Metabotropic glutamate GRM1 mGlu1 Rat L-Glutamic Acid Principal 1 Small molecule OC(=O)CC[C@@H](C(=O)O)N WHUUTDBJXJRKMK-VKHMYHEASA-N 4.8 4.9 5.0 6.4 6.5 6.5 Refs
A (Rhodopsin) Chemerin CML1 chemerin Human 18r-Hepe 2 Small molecule CC[C@H](/C=C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O)O LRWYBGFSVUBWMO-UAAZXLHOSA-N
A (Rhodopsin) Endothelin EDNRA ETA Human Endothelin-2 1 Peptide - MLFJHYIHIKEBTQ-IYRKOGFYSA-N Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT7R 5-HT7 Rat 5-Hydroxytryptamine Principal 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 8.1 8.9 9.6 Refs
A (Rhodopsin) Free fatty acid FFAR1 FFA1 Human Myristic Acid None 3 Small molecule CCCCCCCCCCCCCC(=O)O TUNFSRHWOTWDNC-UHFFFAOYSA-N 4.5 4.8 5.1 Refs
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl13 Peptide - -
A (Rhodopsin) Somatostatin SSR4 SST4 Human Srif-14 2 Peptide - VVEJUSYNERNRME-XGFVQVCISA-N 8.4 8.9 9.3 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT5A 5-HT5A Rat 5-Hydroxytryptamine Principal 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 6.0 6.3 6.6 Refs
C (Glutamate) Metabotropic glutamate GRM6 mGlu6 Human L-Glutamic Acid None 2 Small molecule OC(=O)CC[C@@H](C(=O)O)N WHUUTDBJXJRKMK-VKHMYHEASA-N 4.8 5.0 5.2 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Pge2 None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O XEYBRNLFEZDVAW-ARSRFYASSA-N 7.3 7.7 7.7 Refs
A (Rhodopsin) Adren ADRB3 β3 Rat (-)-Adrenaline None 3 Small molecule CNC[C@@H](c1ccc(c(c1)O)O)O UCTWMZQNUQWSLP-VIFPVBQESA-N
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Cck-8 1 Peptide - IZTQOLKUZKXIRV-YRVFCXMDSA-N Refs
A (Rhodopsin) Peptide P518 QRFPR QRFP Mouse Qrfp43 4 Peptide - - 6.7 7.0 7.2 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl26 5 Peptide - - Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Human Tyramine None 3 Small molecule NCCc1ccc(cc1)O DZGWFCGJZKJUFP-UHFFFAOYSA-N 5.8 6.3 6.7 6.4 6.4 Refs
A (Rhodopsin) Free fatty acid FFAR4 FFA4 Human Myristic Acid None 3 Small molecule CCCCCCCCCCCCCC(=O)O TUNFSRHWOTWDNC-UHFFFAOYSA-N 5.2 5.2 Refs
B1 (Secretin) Glucagon receptor family SCTR secretin Rat Secretin 2 Peptide - - 8.0 8.5 9.0 Refs
A (Rhodopsin) Tachykinin NK1R NK1 Human Neuropeptide K 4 Peptide - - Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR3 S1P3 Mouse Sphingosine 1-Phosphate None 1 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O DUYSYHSSBDVJSM-KRWOKUGFSA-N 8.4 9.1 9.8 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Mouse 3-Iodothyronamine None 1 Small molecule NCCc1ccc(cc1)Oc1ccc(c(c1)I)O HCYGDNGLWSZCCA-UHFFFAOYSA-N 7.5 7.7 7.9 Refs
A (Rhodopsin) Adren ADRB3 β3 Human (&Plusmn;)-Adrenaline None 3 Small molecule CNCC(c1ccc(c(c1)O)O)O UCTWMZQNUQWSLP-UHFFFAOYSA-N 3.9 5.3 5.3 Refs
A (Rhodopsin) Dopamine DRD1 D1 Human (-)-Noradrenaline None 3 Small molecule NC[C@@H](c1ccc(c(c1)O)O)O SFLSHLFXELFNJZ-QMMMGPOBSA-N
A (Rhodopsin) Galanin GALR2 GAL2 Human Spexin-1 3 Peptide - - 6.8 6.8 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR2 S1P2 Mouse Sphingosine 1-Phosphate None 1 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O DUYSYHSSBDVJSM-KRWOKUGFSA-N 8.1 8.3 8.5 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl5 7 Peptide - -
A (Rhodopsin) P2Y P2Y14 P2Y14 Human Udp-Galactose None 2 Small molecule OC[C@H]1O[C@H](OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2ccc(=O)[nH]c2=O)O)O)[C@@H]([C@H]([C@H]1O)O)O HSCJRCZFDFQWRP-ABVWGUQPSA-N 7.6 7.6 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Rat Srif-28 1 Peptide - GGYTXJNZMFRSLX-DFTNLTQTSA-N 9.2 9.8 10.3 Refs
A (Rhodopsin) Prostanoid PF2R FP Human Pgf2Α None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O PXGPLTODNUVGFL-YNNPMVKQSA-N 7.9 8.2 8.5 Refs
A (Rhodopsin) Prokineticin PKR1 PKR1 Human Prokineticin-1 4 Peptide - -
A (Rhodopsin) Adenosine AA3R A3 Human Adenosine Principal 1 Small molecule OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N OIRDTQYFTABQOQ-KQYNXXCUSA-N 6.5 6.5 Refs
A (Rhodopsin) Melanocortin MC3R MC3 Human Β-Msh 3 Peptide - -
A (Rhodopsin) Somatostatin SSR4 SST4 Human Srif-28 3 Peptide - GGYTXJNZMFRSLX-DFTNLTQTSA-N 8.1 8.7 9.2 Refs
B1 (Secretin) Glucagon receptor family GHRHR GHRH Human Ghrh Principal 1 Peptide - -
A (Rhodopsin) Tachykinin NK2R NK2 Human Neurokinin A 1 Peptide - HEAUFJZALFKPBA-JPQUDPSNSA-N 8.0 8.6 9.1 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT6R 5-HT6 Rat 5-Hydroxytryptamine Principal 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 6.6 7.3 7.9 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Pge2 None 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O XEYBRNLFEZDVAW-ARSRFYASSA-N 6.1 6.1 8.1 8.6 9.1 Refs
A (Rhodopsin) Free fatty acid FFAR1 FFA1 Human Oleic Acid None 3 Small molecule CCCCCCCC/C=C\CCCCCCCC(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 3.9 4.8 5.7 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl3 1 Peptide - - 7.8 9.0 10.2 Refs
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl8 Peptide - -
A (Rhodopsin) Prolactin-releasing peptide PRLHR PrRP Human Prrp-20 1 Peptide - - 9.0 9.3 9.6 Refs
A (Rhodopsin) Tachykinin NK1R NK1 Human Neurokinin A 2 Peptide - HEAUFJZALFKPBA-JPQUDPSNSA-N 6.2 7.8 9.3 Refs
A (Rhodopsin) Vasopressin and oxytocin OXYR OT Human Oxytocin 1 Peptide - XNOPRXBHLZRZKH-DSZYJQQASA-N 8.2 8.9 9.6 Refs
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl2 Peptide - -
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl23 2 Peptide - - 8.9 8.9 Refs
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl11 Peptide - -
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Cck-4 2 Peptide - RGYLYUZOGHTBRF-UHFFFAOYSA-N
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Prrp-31 3 Peptide - -
A (Rhodopsin) Endothelin EDNRB ETB Human Endothelin-3 1 Peptide - - Refs
A (Rhodopsin) Kisspeptin KISSR kisspeptin Human Kisspeptin-54 2 Peptide - - 8.8 9.2 9.5 Refs
B1 (Secretin) Glucagon receptor family GLP1R GLP-1 Human Glucagon 2 Peptide - MASNOZXLGMXCHN-ZLPAWPGGSA-N 6.9 7.0 7.0 Refs
A (Rhodopsin) Adren ADRB2 β2 Human (-)-Noradrenaline None 2 Small molecule NC[C@@H](c1ccc(c(c1)O)O)O SFLSHLFXELFNJZ-QMMMGPOBSA-N 6.4 6.4 4.6 5.0 5.4 Refs
A (Rhodopsin) Prostanoid PI2R IP Human Pgi2 None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O KAQKFAOMNZTLHT-OZUDYXHBSA-N 7.8 7.8 Refs
B1 (Secretin) Glucagon receptor family GHRHR GHRH Human Ghrh Principal 1 Peptide - -
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Pacap-27 2 Peptide - RZGBUJXSKLDAFE-UHFFFAOYSA-N 7.6 8.5 9.4 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Human Pge1 None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O GMVPRGQOIOIIMI-DWKJAMRDSA-N 8.0 8.0 Refs
A (Rhodopsin) Vasopressin and oxytocin V2R V2 Human Vasopressin 1 Peptide - KBZOIRJILGZLEJ-LGYYRGKSSA-N 7.9 8.5 9.1 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl5 4 Peptide - - 6.8 7.5 8.2 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Mouse Pge2 None 5 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O XEYBRNLFEZDVAW-ARSRFYASSA-N 5.3 5.3 Refs
C (Glutamate) Metabotropic glutamate GRM2 mGlu2 Human L-Glutamic Acid Principal 1 Small molecule OC(=O)CC[C@@H](C(=O)O)N WHUUTDBJXJRKMK-VKHMYHEASA-N 4.7 5.1 5.4 5.4 5.7 5.9 Refs
A (Rhodopsin) Neurotensin NTR1 NTS1 Rat Neurotensin 1 Peptide - PCJGZPGTCUMMOT-ISULXFBGSA-N 8.2 9.1 10.0 Refs
A (Rhodopsin) Relaxin family peptide RXFP2 RXFP2 Human Insl3 2 Peptide - - 9.3 9.5 9.7 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT7R 5-HT7 Mouse 5-Hydroxytryptamine Principal 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 8.1 8.9 9.6 Refs
A (Rhodopsin) Gonadotrophin-releasing hormone GNRHR GnRH1 Rat Gnrh I 1 Peptide - NMJREATYWWNIKX-UHFFFAOYSA-N 7.8 10.0 10.0 7.3 6.8 6.8 Refs
A (Rhodopsin) Prostanoid PF2R FP Mouse Pgd2 None 2 Small molecule CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O BHMBVRSPMRCCGG-OUTUXVNYSA-N 7.3 7.3 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Pacap-38 3 Peptide - - 7.4 8.6 9.7 8.2 8.2 Refs
A (Rhodopsin) Galanin GALR2 GAL2 Mouse Galanin 2 Peptide - - 8.3 8.3 8.3 8.8 9.3 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Rat Pgf2Α None 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O PXGPLTODNUVGFL-YNNPMVKQSA-N 6.2 6.3 6.3 Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Serum Amyloid A 6 Peptide - - 6.6 6.6 Refs
A (Rhodopsin) Tachykinin NK3R NK3 Human Neurokinin B 1 Peptide - NHXYSAFTNPANFK-HDMCBQFHSA-N 8.4 8.4 7.7 8.5 9.2 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Rat Srif-14 3 Peptide - VVEJUSYNERNRME-XGFVQVCISA-N 8.4 9.2 9.9 Refs
A (Rhodopsin) Dopamine DRD5 D5 Human Dopamine None 1 Small molecule NCCc1ccc(c(c1)O)O VYFYYTLLBUKUHU-UHFFFAOYSA-N 6.6 6.6 Refs
A (Rhodopsin) Adren ADA1D α1D Human (-)-Noradrenaline None 2 Small molecule NC[C@@H](c1ccc(c(c1)O)O)O SFLSHLFXELFNJZ-QMMMGPOBSA-N 6.6 7.2 7.8 5.5 6.5 7.4 Refs
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Cck-39 2 Peptide - -
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl1 2 Peptide - - 8.4 9.1 9.7 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Rat Pge1 None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O GMVPRGQOIOIIMI-DWKJAMRDSA-N 9.5 9.5 8.7 8.7 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Rat Pgd2 None 2 Small molecule CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O BHMBVRSPMRCCGG-OUTUXVNYSA-N 8.8 8.8 8.7 8.9 9.0 Refs
A (Rhodopsin) Chemokine CCR6 CCR6 Human Beta-Defensin 4a 2 Peptide - - Refs
A (Rhodopsin) Adren ADA2B α2B Human (-)-Noradrenaline None 1 Small molecule NC[C@@H](c1ccc(c(c1)O)O)O SFLSHLFXELFNJZ-QMMMGPOBSA-N 6.9 7.4 7.8 3.5 4.8 6.0 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Rat Pge2 None 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O XEYBRNLFEZDVAW-ARSRFYASSA-N 6.1 6.1 8.1 8.6 9.1 Refs
C (Glutamate) Class C Orphan GPC6A GPRC6 Human L-Serine None 5 Small molecule OC[C@@H](C(=O)O)N MTCFGRXMJLQNBG-REOHCLBHSA-N 3.2 3.2 Refs
A (Rhodopsin) Ghrelin GHSR ghrelin Human [Des-Gln14]Ghrelin 2 Peptide - -
A (Rhodopsin) P2Y P2Y14 P2Y14 Rat Udp N-Acetyl-Glucosamine None 5 Small molecule OC[C@H]1O[C@H](OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2ccc(=O)[nH]c2=O)O)O)[C@@H]([C@H]([C@@H]1O)O)NC(=O)C LFTYTUAZOPRMMI-CFRASDGPSA-N 6.8 6.8 Refs
A (Rhodopsin) Adenosine AA2AR A2A Human Adenosine Principal 1 Small molecule OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N OIRDTQYFTABQOQ-KQYNXXCUSA-N 6.5 6.5 Refs
A (Rhodopsin) Tachykinin NK2R NK2 Human Substance P 2 Peptide - ADNPLDHMAVUMIW-CUZNLEPHSA-N 5.9 6.4 6.9 Refs
A (Rhodopsin) Free fatty acid FFAR4 FFA4 Rat Α-Linolenic Acid None 2 Small molecule CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O DTOSIQBPPRVQHS-PDBXOOCHSA-N 5.5 5.5 Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Human Udp None 6 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O XCCTYIAWTASOJW-XVFCMESISA-N 6.0 7.4 8.8 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Rat Corticotrophin-Releasing Hormone 1 Peptide - - 7.8 7.8 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR4 S1P4 Mouse Sphingosine 1-Phosphate None 1 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O DUYSYHSSBDVJSM-KRWOKUGFSA-N 7.2 7.7 8.1 Refs
A (Rhodopsin) Opioid OPRM μ Human Dynorphin A-(1-8) 3 Peptide - WRPLGMBDXVBPEG-VGXZEHLRSA-N 8.4 8.4 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Rat Pge2 None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O XEYBRNLFEZDVAW-ARSRFYASSA-N 9.4 9.4 9.0 9.0 Refs
C (Glutamate) Metabotropic glutamate GRM3 mGlu3 Human L-Glutamic Acid None 1 Small molecule OC(=O)CC[C@@H](C(=O)O)N WHUUTDBJXJRKMK-VKHMYHEASA-N 5.3 5.4 5.4 7.4 7.4 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Rat Oxytocin 2 Peptide - XNOPRXBHLZRZKH-DSZYJQQASA-N 6.9 6.1 6.1 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Human Cst-17 2 Peptide - - 8.8 9.1 9.3 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR1 CRF1 Human Urocortin 1 1 Peptide - - Refs
A (Rhodopsin) Free fatty acid FFAR2 FFA2 Human Butyric Acid None 4 Small molecule CCCC(=O)O FERIUCNNQQJTOY-UHFFFAOYSA-N 2.9 3.8 4.6 Refs
C (Glutamate) Metabotropic glutamate GRM5 mGlu5 Rat L-Glutamic Acid Principal 1 Small molecule OC(=O)CC[C@@H](C(=O)O)N WHUUTDBJXJRKMK-VKHMYHEASA-N 5.0 5.3 5.5 Refs
C (Glutamate) Class C Orphan GPC6A GPRC6 Human L-Arginine None 1 Small molecule OC(=O)[C@H](CCCN=C(N)N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 4.4 4.4 Refs
A (Rhodopsin) Bradykinin BKRB2 B2 Human [Des-Arg9]Bradykinin 2 Peptide - VCEHWDBVPZFHAG-UHFFFAOYSA-N Refs
A (Rhodopsin) Prostanoid TA2R TP Human Thromboxane A2 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1O[C@H]2C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O2)O DSNBHJFQCNUKMA-SCKDECHMSA-N
A (Rhodopsin) Histamine HRH3 H3 Mouse Histamine Principal 1 Small molecule NCCc1cnc[nH]1 NTYJJOPFIAHURM-UHFFFAOYSA-N 7.1 7.5 7.8 Refs
A (Rhodopsin) Prostanoid TA2R TP Human Pgf2Α None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O PXGPLTODNUVGFL-YNNPMVKQSA-N 5.1 5.1 Refs
A (Rhodopsin) Class A orphan GPR32 GPR32 Human Lxa4 None 2 Small molecule CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O IXAQOQZEOGMIQS-SSQFXEBMSA-N 9.7 9.7 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Human [Des-Arg9]Bradykinin 2 Peptide - VCEHWDBVPZFHAG-UHFFFAOYSA-N 5.7 9.2 9.2 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Human Pgd2 None 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O BHMBVRSPMRCCGG-OUTUXVNYSA-N 7.9 7.9 5.9 7.4 8.9 Refs
A (Rhodopsin) Tachykinin NK1R NK1 Human Substance P 1 Peptide - ADNPLDHMAVUMIW-CUZNLEPHSA-N 8.5 9.4 10.3 Refs
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM2 M2 Rat Acetylcholine Principal 1 Small molecule CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 4.3 6.4 6.4 Refs
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM1 M1 Human Acetylcholine Principal 1 Small molecule CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 4.3 4.6 4.9 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Human Kallidin 3 Peptide - FYSKZKQBTVLYEQ-FSLKYBNLSA-N 7.0 8.0 8.9 Refs
A (Rhodopsin) Opioid OPRD δ Mouse [Met]Enkephalin 7 Peptide - YFGBQHOOROIVKG-FKBYEOEOSA-N Refs
A (Rhodopsin) Prokineticin PKR1 PKR1 Human Prokineticin-2 4 Peptide - -
A (Rhodopsin) Leukotriene OXER1 OXE Human 5-Oxo-12-Hete None 7 Small molecule CCCCC/C=C\C[C@@H](/C=C/C=C\C=C\C(=O)CCCC(=O)O)O MLZJFLKEKVDNAZ-XPKTZJOPSA-N Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Ccl20 5 Peptide - - 6.8 6.8 Refs
A (Rhodopsin) Prolactin-releasing peptide PRLHR PrRP Human Neuropeptide Y 3 Peptide - XKWCTHKJQNUFOQ-HRPSIEBRSA-N 5.4 5.4 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Human Pgj2 None 3 Small molecule CCCCC[C@@H](/C=C/[C@@H]1[C@@H](C/C=C\CCCC(=O)O)C=CC1=O)O UQOQENZZLBSFKO-POPPZSFYSA-N 7.3 7.3 Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Aspirin Triggered Lipoxin A4 None 9 Small molecule CCCCC[C@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O IXAQOQZEOGMIQS-JEWNPAEBSA-N
B1 (Secretin) VIP and PACAP PACR PAC1 Rat Pacap-38 1 Peptide - - 9.5 9.8 10.0 6.9 8.2 9.0 Refs
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Cck-33 2 Peptide - QFLBZJPOIZFFJQ-UHFFFAOYSA-N
A (Rhodopsin) Class A orphan GPR39 GPR39 Human Obestatin Peptide - -
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide B-23 5 Peptide - -
A (Rhodopsin) Somatostatin SSR2 SST2 Rat Srif-14 1 Peptide - VVEJUSYNERNRME-XGFVQVCISA-N 9.0 9.1 9.1 8.9 8.8 8.8 Refs
A (Rhodopsin) Neuropeptide Y NPY1R Y1 Human Peptide Yy 4 Peptide - -
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Mouse Cramp 5 Peptide - QBSFTGGUOCPHDM-GDCSACRRSA-N 6.7 6.9 7.0 Refs
A (Rhodopsin) Class A orphan GP182 GPR182 Rat Adrenomedullin Principal 1 Peptide - - 8.1 8.1 Refs
A (Rhodopsin) Gonadotrophin-releasing hormone GNRHR GnRH1 Mouse Gnrh I 1 Peptide - NMJREATYWWNIKX-UHFFFAOYSA-N 7.8 10.0 10.0 7.3 6.8 6.8 Refs
C (Glutamate) Metabotropic glutamate GRM4 mGlu4 Human L-Serine-O-Phosphate None 1 Small molecule OC(=O)[C@H](COP(=O)(O)O)N BZQFBWGGLXLEPQ-REOHCLBHSA-N 5.9 5.9 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Cck-39 5 Peptide - -
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Aspirin-Triggered Resolvin D1 None 3 Small molecule CC/C=C\C[C@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](C/C=C\CCC(=O)O)O)O)O OIWTWACQMDFHJG-BJEBZIPWSA-N 11.1 11.1 Refs
C (Glutamate) Metabotropic glutamate GRM4 mGlu4 Human L-Glutamic Acid None 2 Small molecule OC(=O)CC[C@@H](C(=O)O)N WHUUTDBJXJRKMK-VKHMYHEASA-N 4.7 5.1 5.5 4.9 5.2 5.5 Refs
A (Rhodopsin) Relaxin family peptide RL3R2 RXFP4 Human Insl5 3 Peptide - - 7.0 7.7 8.9 7.3 8.1 8.8 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Rat Pge1 None 2 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O GMVPRGQOIOIIMI-DWKJAMRDSA-N 7.4 7.4 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR5 S1P5 Mouse Sphingosine 1-Phosphate None 1 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O DUYSYHSSBDVJSM-KRWOKUGFSA-N 7.8 7.9 7.9 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Mouse Pge1 None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O GMVPRGQOIOIIMI-DWKJAMRDSA-N 9.5 9.5 8.7 8.7 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Human Corticotrophin-Releasing Hormone 1 Peptide - - 7.8 7.8 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Human Srif-14 3 Peptide - VVEJUSYNERNRME-XGFVQVCISA-N 8.4 9.2 9.9 Refs
A (Rhodopsin) GPR18, GPR55 and GPR119 GPR55 GPR55 Human Anandamide None 3 Small molecule CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCO LGEQQWMQCRIYKG-DOFZRALJSA-N 7.7 7.7 Refs
A (Rhodopsin) Ghrelin GHSR ghrelin Human Ghrelin 1 Peptide - - 7.2 8.1 9.5 7.8 8.0 8.1 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT6R 5-HT6 Human 5-Hydroxytryptamine Principal 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 6.6 7.3 7.9 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl11 1 Peptide - - 9.7 9.9 10.0 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl8 7 Peptide - -
A (Rhodopsin) Trace amine TAAR1 TA1 Rat Β-Phenylethylamine None 2 Small molecule NCCc1ccccc1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 6.2 6.6 7.0 Refs
A (Rhodopsin) Chemokine CCR7 CCR7 Human Ccl21 2 Peptide - - Refs
A (Rhodopsin) Cannabinoid CNR2 CB2 Human Anandamide None 2 Small molecule CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCO LGEQQWMQCRIYKG-DOFZRALJSA-N 5.7 6.1 6.4 Refs
A (Rhodopsin) Vasopressin and oxytocin V2R V2 Human Oxytocin 2 Peptide - XNOPRXBHLZRZKH-DSZYJQQASA-N 5.4 6.1 6.8 Refs
A (Rhodopsin) Dopamine DRD2 D2 Human Dopamine Principal 1 Small molecule NCCc1ccc(c(c1)O)O VYFYYTLLBUKUHU-UHFFFAOYSA-N 4.7 6.0 7.2 Refs
A (Rhodopsin) Orexin OX1R OX1 Human Orexin-A 1 Peptide - - 6.5 8.4 10.2 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1B 5-HT1B Mouse 5-Hydroxytryptamine None 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 7.4 8.2 9.0 Refs
A (Rhodopsin) Prostanoid PD2R DP1 Rat Pgd2 None 2 Small molecule CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O BHMBVRSPMRCCGG-OUTUXVNYSA-N 7.8 7.6 7.6 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Mouse Srif-28 3 Peptide - GGYTXJNZMFRSLX-DFTNLTQTSA-N 8.1 9.0 9.9 Refs
A (Rhodopsin) Peptide P518 QRFPR QRFP Human Qrfp43 (43rfa) 3 Peptide - - 6.9 7.8 8.6 Refs
A (Rhodopsin) Neuropeptide Y NPY1R Y1 Rat Pancreatic Polypeptide 3 Peptide - - 7.0 7.0 Refs
A (Rhodopsin) P2Y P2RY1 P2Y1 Human Atp None 1 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N ZKHQWZAMYRWXGA-KQYNXXCUSA-N 4.8 4.8 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Neuropeptide Ff 1 Peptide - - 9.7 9.7 Refs
A (Rhodopsin) Relaxin family peptide RXFP1 RXFP1 Human Relaxin-3 3 Peptide - - 7.5 7.8 8.0 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Human Pacap-27 2 Peptide - RZGBUJXSKLDAFE-UHFFFAOYSA-N 7.4 8.9 10.6 6.9 8.0 8.5 Refs
A (Rhodopsin) Neurotensin NTR2 NTS2 Mouse Neurotensin 1 Peptide - PCJGZPGTCUMMOT-ISULXFBGSA-N 8.8 8.8 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Human Vasopressin 1 Peptide - KBZOIRJILGZLEJ-LGYYRGKSSA-N 8.5 8.9 9.3 Refs
A (Rhodopsin) Apelin APJ apelin Human Apelin-36 2 Peptide - BVTLGARMSLXAHI-VDEROMQGSA-N Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Pge1 None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O GMVPRGQOIOIIMI-DWKJAMRDSA-N 9.5 9.5 8.7 8.7 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Rat Pacap-27 2 Peptide - RZGBUJXSKLDAFE-UHFFFAOYSA-N 7.6 8.5 9.4 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT2B 5-HT2B Rat 5-Hydroxytryptamine Principal 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 7.9 8.0 8.0 Refs
A (Rhodopsin) Galanin GALR2 GAL2 Human Galanin 1 Peptide - CBSXZYWGVAQSHI-RUKUCZSXSA-N 7.9 8.5 9.1 8.6 8.9 9.1 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Neuropeptide Sf 3 Peptide - -
A (Rhodopsin) Somatostatin SSR4 SST4 Human Cst-17 1 Peptide - - 8.5 9.1 9.6 Refs
B1 (Secretin) Parathyroid hormone PTH1R PTH1 Human Tip39 1 Peptide - - Refs
A (Rhodopsin) Formylpeptide FPR3 FPR3 Human Annexin I-(2-26) 3 Peptide - - 5.0 6.0 7.0 Refs
F (Frizzled) Frizzled FZD6 FZD6 Human Wnt-3a Peptide - - Refs
A (Rhodopsin) Chemokine CCR6 CCR6 Human Ccl20 1 Peptide - - Refs
A (Rhodopsin) Adren ADA2A α2A Human (-)-Adrenaline None 1 Small molecule CNC[C@@H](c1ccc(c(c1)O)O)O UCTWMZQNUQWSLP-VIFPVBQESA-N 5.5 6.8 8.0 3.7 5.6 7.4 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT5A 5-HT5A Human 5-Hydroxytryptamine Principal 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 6.0 6.3 6.6 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Rat Pge2 None 2 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O XEYBRNLFEZDVAW-ARSRFYASSA-N 7.5 7.9 8.3 Refs
A (Rhodopsin) Class A orphan LGR5 LGR5 Human R-Spondin-2 1 Peptide - - 12.0 12.0 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl15 5 Peptide - - Refs
A (Rhodopsin) Endothelin EDNRB ETB Human Endothelin-1 2 Peptide - ZUBDGKVDJUIMQQ-ZTNLKOGPSA-N
A (Rhodopsin) Chemokine CX3C1 CX3CR1 Human Cx3Cl1 Principal 1 Peptide - - Refs
A (Rhodopsin) Vasopressin and oxytocin V1BR V1B Human Oxytocin 2 Peptide - XNOPRXBHLZRZKH-DSZYJQQASA-N 5.7 6.4 7.0 Refs
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Pthrp 5 Peptide - -
A (Rhodopsin) Chemokine ACKR4 ACKR4 Human Ccl19 1 Peptide - - 8.5 8.8 9.1 8.4 8.4 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1E 5-HT1E Human Tryptamine None 2 Small molecule NCCc1c[nH]c2c1cccc2 APJYDQYYACXCRM-UHFFFAOYSA-N 5.6 6.1 6.5 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Rat Tyramine None 3 Small molecule NCCc1ccc(cc1)O DZGWFCGJZKJUFP-UHFFFAOYSA-N 5.8 6.3 6.7 6.4 6.4 Refs
A (Rhodopsin) Chemokine CXCR1 CXCR1 Human Cxcl8 1 Peptide - - 8.8 9.2 9.5 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1B 5-HT1B Human 5-Hydroxytryptamine None 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 7.4 8.2 9.0 Refs
A (Rhodopsin) Prokineticin PKR1 PKR1 Human Prokineticin-1 3 Peptide - - Refs
A (Rhodopsin) Galanin GALR1 GAL1 Human Galanin 2 Peptide - CBSXZYWGVAQSHI-RUKUCZSXSA-N 9.1 9.8 10.5 Refs
A (Rhodopsin) Chemerin CML1 chemerin Human Chemerin 1 Peptide - - 7.6 8.0 8.5 Refs
A (Rhodopsin) Free fatty acid FFAR2 FFA2 Human Acetic Acid None 2 Small molecule CC(=O)O QTBSBXVTEAMEQO-UHFFFAOYSA-N 3.1 3.9 4.6 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Mouse Pgf2Α None 4 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O PXGPLTODNUVGFL-YNNPMVKQSA-N 6.4 6.4 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Rat Pgd2 None 4 Small molecule CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O BHMBVRSPMRCCGG-OUTUXVNYSA-N 5.3 5.3 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Thromboxane A2 6 Small molecule CCCCC[C@@H](/C=C/[C@H]1O[C@H]2C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O2)O DSNBHJFQCNUKMA-SCKDECHMSA-N
A (Rhodopsin) Free fatty acid FFAR3 FFA3 Human Butyric Acid None 2 Small molecule CCCC(=O)O FERIUCNNQQJTOY-UHFFFAOYSA-N 3.8 4.4 4.9 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1D 5-HT1D Human 5-Hydroxytryptamine None 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 8.0 8.5 9.0 Refs
A (Rhodopsin) Kisspeptin KISSR kisspeptin Human Kisspeptin-52 5 Peptide - -
A (Rhodopsin) Class A orphan GPR6 GPR6 Mouse Sphingosine 1-Phosphate Principal 1 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O DUYSYHSSBDVJSM-KRWOKUGFSA-N 7.3 7.5 7.7 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Vip 1 Peptide - VBUWHHLIZKOSMS-UHFFFAOYSA-N 7.9 9.0 10.0 8.5 9.2 9.8 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl7 3 Peptide - - 8.1 8.1 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Human Urocortin 2 2 Peptide - -
A (Rhodopsin) Kisspeptin KISSR kisspeptin Human Kisspeptin-10 1 Peptide - RITKWYDZSSQNJI-INXYWQKQSA-N 8.6 9.5 10.4 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Mouse Pge1 None 2 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O GMVPRGQOIOIIMI-DWKJAMRDSA-N 7.4 7.4 Refs
B1 (Secretin) Glucagon receptor family GLR glucagon Human Glucagon Principal 1 Peptide - MASNOZXLGMXCHN-ZLPAWPGGSA-N 9.0 9.0 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT4R 5-HT4 Mouse 5-Hydroxytryptamine Principal 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 5.9 7.2 7.2 Refs
A (Rhodopsin) Chemokine CCR10 CCR10 Human Ccl27 Peptide - -
A (Rhodopsin) Gonadotrophin-releasing hormone GNRHR GnRH1 Human Gnrh Ii 2 Peptide - - Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Human Srif-28 3 Peptide - GGYTXJNZMFRSLX-DFTNLTQTSA-N 8.1 9.0 9.9 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR2 LPA2 Human Lpa None 1 Small molecule CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O WRGQSWVCFNIUNZ-KTKRTIGZSA-N 6.7 7.5 8.2 Refs
A (Rhodopsin) Adren ADA2B α2B Human (-)-Adrenaline None 2 Small molecule CNC[C@@H](c1ccc(c(c1)O)O)O UCTWMZQNUQWSLP-VIFPVBQESA-N 6.3 6.9 7.5 3.6 4.4 5.2 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl24 5 Peptide - -
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Ccl14 Peptide - -
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Neuropeptide Sf 3 Peptide - -
A (Rhodopsin) 5-Hydroxytryptamine 5HT2A 5-HT2A Human 5-Hydroxytryptamine None 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 6.0 7.2 8.4 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Mouse Pge2 None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O XEYBRNLFEZDVAW-ARSRFYASSA-N 9.4 9.4 9.0 9.0 Refs
A (Rhodopsin) Leukotriene CLTR1 CysLT1 Human Ltd4 None 1 Small molecule CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N YEESKJGWJFYOOK-LDDGIIIKSA-N 7.3 8.6 9.4 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Human Pgf2Α None 2 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O PXGPLTODNUVGFL-YNNPMVKQSA-N 8.4 8.4 7.1 7.1 Refs
A (Rhodopsin) Neuropeptide Y NPY2R Y2 Human Pancreatic Polypeptide 5 Peptide - -
A (Rhodopsin) Chemokine CCR9 CCR9 Human Ccl25 Principal 1 Peptide - -
A (Rhodopsin) Prostanoid PE2R3 EP3 Rat Pgd2 None 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O BHMBVRSPMRCCGG-OUTUXVNYSA-N 7.9 7.9 5.9 7.4 8.9 Refs
A (Rhodopsin) Relaxin family peptide RXFP2 RXFP2 Human Relaxin-3 2 Peptide - - 7.0 7.0 Refs
A (Rhodopsin) Dopamine DRD1 D1 Human Noradrenaline None 3 Small molecule NCC(c1ccc(c(c1)O)O)O SFLSHLFXELFNJZ-UHFFFAOYSA-N 4.3 4.3 Refs
A (Rhodopsin) Bombesin NMBR BB1 Human Gastrin Releasing Peptide(14-27) (Human) None 2 Peptide - MJHJYGACUDLDMG-QEJDUTAOSA-N Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Human Udp-Glucuronic Acid None 4 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(O[C@H]2O[C@H](C(=O)O)[C@H]([C@@H]([C@H]2O)O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O HDYANYHVCAPMJV-LXQIFKJMSA-N
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Lxa4 None 1 Small molecule CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O IXAQOQZEOGMIQS-SSQFXEBMSA-N 12.0 12.0 Refs
F (Frizzled) Frizzled FZD1 FZD1 Human Wnt-7b Peptide - -
A (Rhodopsin) Chemokine CXCR4 CXCR4 Human Cxcl12Γ 3 Peptide - - Refs
C (Glutamate) Metabotropic glutamate GRM4 mGlu4 Rat L-Serine-O-Phosphate None 1 Small molecule OC(=O)[C@H](COP(=O)(O)O)N BZQFBWGGLXLEPQ-REOHCLBHSA-N 5.9 5.9 Refs
A (Rhodopsin) Adren ADRB3 β3 Human (+)-Adrenaline None 3 Small molecule CNC[C@H](c1ccc(c(c1)O)O)O UCTWMZQNUQWSLP-SECBINFHSA-N
A (Rhodopsin) Opioid OPRK κ Human Dynorphin A-(1-13) 2 Peptide - OVVIBUHLQIYUEU-IWIISZHXSA-N 9.3 10.0 10.7 Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Mouse Udp-Glucose None 4 Small molecule OC[C@H]1O[C@H](OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2ccc(=O)[nH]c2=O)O)O)[C@@H]([C@H]([C@@H]1O)O)O HSCJRCZFDFQWRP-JZMIEXBBSA-N 5.9 7.7 9.5 Refs
B1 (Secretin) Glucagon receptor family GIPR GIP Human Gastric Inhibitory Polypeptide Principal 1 Peptide - - 9.1 9.1 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR1 CRF1 Human Corticotrophin-Releasing Hormone 2 Peptide - - Refs
A (Rhodopsin) Prostanoid PD2R DP1 Human Pgf2Α None 5 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O PXGPLTODNUVGFL-YNNPMVKQSA-N 6.1 6.3 6.4 Refs
A (Rhodopsin) Dopamine DRD1 D1 Human Dopamine None 2 Small molecule NCCc1ccc(c(c1)O)O VYFYYTLLBUKUHU-UHFFFAOYSA-N 4.3 5.0 5.6 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Neuropeptide Ff 2 Peptide - - 8.5 9.2 9.9 Refs
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Ccl2 Peptide - -
A (Rhodopsin) Opioid OPRM μ Rat [Met]Enkephalin 1 Peptide - YFGBQHOOROIVKG-FKBYEOEOSA-N 9.2 9.2 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Human Neuropeptide Y 4 Peptide - XKWCTHKJQNUFOQ-HRPSIEBRSA-N 6.4 8.0 8.0 Refs
B1 (Secretin) Calcitonin CALCR CT Human Calcitonin 1 Peptide - LDVRMNJZLWXJPL-GXQFRRLTSA-N 9.0 10.1 11.2 Refs
A (Rhodopsin) Endothelin EDNRA ETA Human Endothelin-3 3 Peptide - -
A (Rhodopsin) Lysophospholipid (S1P) S1PR3 S1P3 Human Sphingosine 1-Phosphate None 1 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O DUYSYHSSBDVJSM-KRWOKUGFSA-N 8.4 9.1 9.8 Refs
A (Rhodopsin) Apelin APJ apelin Human [Pyr1]Apelin-13 2 Peptide - - Refs
A (Rhodopsin) P2Y P2RY4 P2Y4 Rat Atp None 2 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N ZKHQWZAMYRWXGA-KQYNXXCUSA-N 5.7 6.0 6.3 Refs
A (Rhodopsin) Opioid OPRD δ Mouse [Leu]Enkephalin 1 Peptide - URLZCHNOLZSCCA-UHFFFAOYSA-N 8.7 8.7 Refs
A (Rhodopsin) Melanocortin MC4R MC4 Human Α-Msh 1 Peptide - - 7.4 7.7 8.0 Refs
A (Rhodopsin) Class A orphan GP174 GPR174 Human Lysophosphatidylserine Principal 1 Small molecule CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OC[C@@H](C(=O)O)N)O)O ZPDQFUYPBVXUKS-YADHBBJMSA-N 7.1 7.1 Refs
A (Rhodopsin) Neurotensin NTR2 NTS2 Rat Neuromedin N 2 Peptide - - Refs
A (Rhodopsin) Proteinase-activated PAR3 PAR3 Human Thrombin Principal 1 Peptide - -
A (Rhodopsin) Somatostatin SSR2 SST2 Mouse Srif-14 1 Peptide - VVEJUSYNERNRME-XGFVQVCISA-N 9.0 9.1 9.1 8.9 8.8 8.8 Refs
A (Rhodopsin) Opioid OPRK κ Rat Β-Neoendorphin 4 Peptide - RTXIYIQLESPXIV-VLOLPVCOSA-N 9.1 9.1 Refs
A (Rhodopsin) Chemokine CCR7 CCR7 Human Ccl19 1 Peptide - - Refs
A (Rhodopsin) P2Y P2RY4 P2Y4 Human Atp None 2 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N ZKHQWZAMYRWXGA-KQYNXXCUSA-N 5.7 6.0 6.3 Refs
A (Rhodopsin) Leukotriene CLTR1 CysLT1 Human Lte4 None 3 Small molecule CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N OTZRAYGBFWZKMX-FRFVZSDQSA-N 6.4 6.7 7.2 7.1 7.5 7.8 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Rat Pgf2Α None 2 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O PXGPLTODNUVGFL-YNNPMVKQSA-N 8.4 8.4 7.1 7.1 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Rat Neuropeptide Y 4 Peptide - XKWCTHKJQNUFOQ-HRPSIEBRSA-N 6.4 8.0 8.0 Refs
A (Rhodopsin) P2Y P2RY1 P2Y1 Human Adp None 2 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N XTWYTFMLZFPYCI-KQYNXXCUSA-N Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl2 6 Peptide - - 7.5 7.5 Refs
C (Glutamate) Metabotropic glutamate GRM6 mGlu6 Rat L-Glutamic Acid None 2 Small molecule OC(=O)CC[C@@H](C(=O)O)N WHUUTDBJXJRKMK-VKHMYHEASA-N 4.8 5.0 5.2 Refs
A (Rhodopsin) Orexin OX2R OX2 Human Orexin-B 1 Peptide - OHOWSYIKESXDMN-WMQZXSDYSA-N 6.5 8.3 10.0 Refs
A (Rhodopsin) Adren ADRB3 β3 Mouse (+)-Adrenaline None 3 Small molecule CNC[C@H](c1ccc(c(c1)O)O)O UCTWMZQNUQWSLP-SECBINFHSA-N
A (Rhodopsin) Prostanoid PD2R DP1 Human Pge2 None 4 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O XEYBRNLFEZDVAW-ARSRFYASSA-N 6.5 6.8 7.0 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Human Pge2 None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O XEYBRNLFEZDVAW-ARSRFYASSA-N 9.4 9.4 9.0 9.0 Refs
A (Rhodopsin) Relaxin family peptide RL3R2 RXFP4 Mouse Insl5 2 Peptide - - 7.8 8.6 9.4 8.5 8.7 8.8 Refs
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Tip39 1 Peptide - - Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl24 5 Peptide - - Refs
A (Rhodopsin) Chemokine CCR6 CCR6 Human Ccl20 2 Peptide - -
A (Rhodopsin) Adren ADRB2 β2 Human Zn2+ None 3 Small molecule [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 3.3 4.3 5.3 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Human Vip 3 Peptide - VBUWHHLIZKOSMS-UHFFFAOYSA-N 6.0 7.0 8.7 6.0 6.9 8.4 Refs
C (Glutamate) Metabotropic glutamate GRM7 mGlu7 Human L-Glutamic Acid None 2 Small molecule OC(=O)CC[C@@H](C(=O)O)N WHUUTDBJXJRKMK-VKHMYHEASA-N 3.0 3.0 3.1 3.1 Refs
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Spinorphin None 2 Peptide - BXIFNVGZIMFBQB-DYDSHOKNSA-N Refs
A (Rhodopsin) Neuromedin U NMUR2 NMU2 Human Neuromedin S-36 3 Peptide - -
A (Rhodopsin) Class A orphan GP139 GPR139 Human L-Phenylalanine None 2 Small molecule N[C@H](C(=O)O)Cc1ccccc1 COLNVLDHVKWLRT-QMMMGPOBSA-N 3.5 3.5 3.1 3.1 Refs
A (Rhodopsin) Histamine HRH4 H4 Mouse Histamine None 1 Small molecule NCCc1cnc[nH]1 NTYJJOPFIAHURM-UHFFFAOYSA-N 7.8 7.4 7.4 Refs
A (Rhodopsin) Vasopressin and oxytocin OXYR OT Rat Oxytocin 1 Peptide - XNOPRXBHLZRZKH-DSZYJQQASA-N 8.2 8.9 9.6 Refs
A (Rhodopsin) Class A orphan MRGX1 MRGPRX1 Human Bovine Adrenal Medulla Peptide 8-22 Principal 1 Peptide - GOEYECACIBFJGZ-NPAGUKBMSA-N 5.3 6.6 7.8 7.7 7.7 Refs
A (Rhodopsin) Orexin OX2R OX2 Human Orexin-A 1 Peptide - - 6.5 8.3 10.0 Refs
C (Glutamate) Metabotropic glutamate GRM8 mGlu8 Human L-Serine-O-Phosphate None 2 Small molecule OC(=O)[C@H](COP(=O)(O)O)N BZQFBWGGLXLEPQ-REOHCLBHSA-N Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT4R 5-HT4 Human 5-Hydroxytryptamine Principal 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 5.9 7.2 7.2 Refs
A (Rhodopsin) Somatostatin SSR1 SST1 Human Srif-14 2 Peptide - VVEJUSYNERNRME-XGFVQVCISA-N 8.6 9.1 9.5 Refs
A (Rhodopsin) Neuropeptide Y NPY2R Y2 Human Pyy-(3-36) 3 Peptide - - 9.2 9.5 9.7 Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Ccl11 4 Peptide - - 7.2 7.2 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Gastrin-17 5 Peptide - -
A (Rhodopsin) Class A orphan GPR17 GPR17 Human Udp-Galactose None 5 Small molecule OC[C@H]1O[C@H](OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2ccc(=O)[nH]c2=O)O)O)[C@@H]([C@H]([C@H]1O)O)O HSCJRCZFDFQWRP-ABVWGUQPSA-N 6.0 7.5 8.9 Refs
A (Rhodopsin) Neuromedin U NMUR1 NMU1 Human Neuromedin U-25 2 Peptide - - 8.4 8.9 9.4 9.5 9.5 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Mouse Bradykinin 4 Peptide - QXZGBUJJYSLZLT-FDISYFBBSA-N 5.1 5.2 5.3 Refs
A (Rhodopsin) Bombesin NMBR BB1 Human Neuromedin B 1 Peptide - YPFNACALNKVZNK-UHFFFAOYSA-N 8.1 9.2 10.3 Refs
A (Rhodopsin) Endothelin EDNRA ETA Human Endothelin-1 2 Peptide - ZUBDGKVDJUIMQQ-ZTNLKOGPSA-N Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Cxcl10 9 Peptide - -
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl2 1 Peptide - - Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl5 2 Peptide - - 8.5 8.9 9.3 Refs
A (Rhodopsin) Prostanoid PI2R IP Human Pge1 None 2 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O GMVPRGQOIOIIMI-DWKJAMRDSA-N 6.5 7.5 7.5 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Human T-Kinin 5 Peptide - GKCWYHPGFSRBQV-WRBAKOPXSA-N 5.0 5.1 5.2 Refs
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Ccl17 Peptide - -
B1 (Secretin) Glucagon receptor family SCTR secretin Rat Vip 2 Peptide - VBUWHHLIZKOSMS-UHFFFAOYSA-N Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl2 5 Peptide - -
C (Glutamate) Calcium-sensing CASR CaS Rat Ca2+ None 2 Small molecule - - Refs
A (Rhodopsin) Chemokine CCR6 CCR6 Human Ccl20 2 Peptide - -
A (Rhodopsin) Opioid OPRM μ Human Dynorphin A 5 Peptide - JMNJYGMAUMANNW-FIXZTSJVSA-N 8.1 8.1 Refs
A (Rhodopsin) Opioid OPRK κ Mouse Dynorphin B 5 Peptide - AGTSSZRZBSNTGQ-ITZCFHCWSA-N 8.1 9.0 9.9 Refs
A (Rhodopsin) Opioid OPRM μ Human Β-Endorphin 6 Peptide - JMHFFDIMOUKDCZ-NTXHZHDSSA-N
A (Rhodopsin) Proteinase-activated PAR4 PAR4 Human Thrombin Peptide - -
A (Rhodopsin) Somatostatin SSR1 SST1 Human Srif-28 3 Peptide - GGYTXJNZMFRSLX-DFTNLTQTSA-N 8.6 9.0 9.4 Refs
A (Rhodopsin) Opioid OPRK κ Rat Dynorphin A-(1-13) 2 Peptide - OVVIBUHLQIYUEU-IWIISZHXSA-N 9.3 10.0 10.7 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Human Oxytocin 2 Peptide - XNOPRXBHLZRZKH-DSZYJQQASA-N 6.9 6.1 6.1 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Mouse Urocortin 3 2 Peptide - - Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl3 5 Peptide - - 8.0 8.5 8.9 Refs
C (Glutamate) Metabotropic glutamate GRM3 mGlu3 Rat L-Glutamic Acid None 1 Small molecule OC(=O)CC[C@@H](C(=O)O)N WHUUTDBJXJRKMK-VKHMYHEASA-N 5.3 5.4 5.4 7.4 7.4 Refs
A (Rhodopsin) Opioid OPRK κ Rat Α-Neoendorphin 3 Peptide - KZTDMJBCZSGHOG-XJIZABAQSA-N 8.3 9.3 10.2 Refs
A (Rhodopsin) Neuropeptide Y Q9ERC0 Y2 Rat Peptide Yy 1 Peptide - IXMRLEGHWROJAA-HDTKZREISA-N 10.0 10.0 Refs
C (Glutamate) Metabotropic glutamate GRM6 mGlu6 Human L-Serine-O-Phosphate None 1 Small molecule OC(=O)[C@H](COP(=O)(O)O)N BZQFBWGGLXLEPQ-REOHCLBHSA-N 6.4 6.4 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Mouse Pge2 None 2 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O XEYBRNLFEZDVAW-ARSRFYASSA-N 7.5 7.9 8.3 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR3 S1P3 Human Sphingosylphosphorylcholine 2 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(OCC[N+](C)(C)C)[O-])N)O JLVSPVFPBBFMBE-HXSWCURESA-N
A (Rhodopsin) Prostanoid PE2R1 EP1 Rat Pge2 None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O XEYBRNLFEZDVAW-ARSRFYASSA-N 7.3 7.7 7.7 Refs
B1 (Secretin) Glucagon receptor family SCTR secretin Human Secretin 1 Peptide - KKNIUBFRGPFELP-UHFFFAOYSA-N 9.7 9.7 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Mouse Pgd3 None 2 Small molecule CCC=CC[C@@H](C=C[C@H]1C(=O)C[C@@H]([C@@H]1CC=CCCCC(=O)O)O)O ANOICLBSJIMQTA-MLHJIOFPSA-N 7.4 7.4 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl8 5 Peptide - -
A (Rhodopsin) Trace amine TAAR1 TA1 Human Octopamine None 4 Small molecule NCC(c1ccc(cc1)O)O QHGUCRYDKWKLMG-UHFFFAOYSA-N
A (Rhodopsin) Prostanoid PE2R3 EP3 Mouse Pge1 None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O GMVPRGQOIOIIMI-DWKJAMRDSA-N 9.4 9.4 9.0 9.0 Refs
A (Rhodopsin) Neuropeptide S NPSR1 NPS Human Neuropeptide S Principal 1 Peptide - - 7.3 7.7 8.0 Refs
A (Rhodopsin) Tachykinin NK1R NK1 Human Neuropeptide-Γ None 4 Peptide - PLSDWRYNZIVQKX-BGKYVOMCSA-N Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Human Urocortin 1 2 Peptide - - Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Γ-Msh 2 Peptide - -
A (Rhodopsin) Prostanoid PF2R FP Mouse Pge2 None 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O XEYBRNLFEZDVAW-ARSRFYASSA-N 6.4 6.7 6.9 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Rat Srif-28 2 Peptide - GGYTXJNZMFRSLX-DFTNLTQTSA-N 8.4 8.8 8.8 Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Ltc4 9 Small molecule CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N GWNVDXQDILPJIG-NXOLIXFESA-N
A (Rhodopsin) Somatostatin SSR3 SST3 Human Srif-14 1 Peptide - VVEJUSYNERNRME-XGFVQVCISA-N 8.7 9.4 10.0 Refs
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl22 Peptide - -
A (Rhodopsin) Class A orphan GP132 GPR132 Human 9-Hydroxyoctadecadienoic Acid Principal 1 Small molecule CCCCC/C=C\C=C\[C@H](CCCCCCCC(=O)O)O NPDSHTNEKLQQIJ-UINYOVNOSA-N 5.7 5.7 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl11 8 Peptide - -
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl11 8 Peptide - -
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM2 M2 Human Acetylcholine Principal 1 Small molecule CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 4.3 6.4 6.4 Refs
A (Rhodopsin) Tachykinin NK3R NK3 Human Substance P 3 Peptide - ADNPLDHMAVUMIW-CUZNLEPHSA-N 5.0 5.5 6.0 Refs
A (Rhodopsin) Neuropeptide Y NPY1R Y1 Human Pancreatic Polypeptide 4 Peptide - -
A (Rhodopsin) Ghrelin GHSR ghrelin Human Ghrelin 2 Peptide - -
A (Rhodopsin) Lysophospholipid (S1P) S1PR5 S1P5 Rat Sphingosine 1-Phosphate None 1 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O DUYSYHSSBDVJSM-KRWOKUGFSA-N 7.8 7.9 7.9 Refs
A (Rhodopsin) Neuropeptide Y NPY2R Y2 Human Neuropeptide Y-(3-36) 5 Peptide - -
A (Rhodopsin) Neuropeptide Y NPY2R Y2 Human Neuropeptide Y 4 Peptide - XKWCTHKJQNUFOQ-HRPSIEBRSA-N 9.3 9.4 9.4 Refs
A (Rhodopsin) Neuropeptide Y NPY2R Y2 Human Peptide Yy 2 Peptide - - 9.5 9.7 9.8 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Rat Bradykinin 4 Peptide - QXZGBUJJYSLZLT-FDISYFBBSA-N 5.1 5.2 5.3 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT7R 5-HT7 Human 5-Hydroxytryptamine Principal 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 8.1 8.9 9.6 Refs
A (Rhodopsin) Adren ADRB1 β1 Human (-)-Adrenaline None 2 Small molecule CNC[C@@H](c1ccc(c(c1)O)O)O UCTWMZQNUQWSLP-VIFPVBQESA-N 7.6 7.6 5.2 5.6 6.0 Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Α-Msh 2 Peptide - - Refs
A (Rhodopsin) Complement peptide C3AR C3a Human C3a 2 Peptide - -
A (Rhodopsin) Bradykinin BKRB2 B2 Human T-Kinin 3 Peptide - GKCWYHPGFSRBQV-WRBAKOPXSA-N
A (Rhodopsin) Bombesin GRPR BB2 Human Grp-(18-27) 3 Peptide - -
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl7 Peptide - -
A (Rhodopsin) Leukotriene CLTR1 CysLT1 Human Ltc4 None 2 Small molecule CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N GWNVDXQDILPJIG-NXOLIXFESA-N 7.4 7.6 7.7 7.0 7.6 8.1 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide B-29 3 Peptide - - Refs
B1 (Secretin) Parathyroid hormone PTH1R PTH1 Human Pthrp 3 Peptide - -
A (Rhodopsin) P2Y P2Y14 P2Y14 Mouse Udp N-Acetyl-Glucosamine None 5 Small molecule OC[C@H]1O[C@H](OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2ccc(=O)[nH]c2=O)O)O)[C@@H]([C@H]([C@@H]1O)O)NC(=O)C LFTYTUAZOPRMMI-CFRASDGPSA-N 6.8 6.8 Refs
A (Rhodopsin) Prostanoid PF2R FP Human Thromboxane A2 4 Small molecule CCCCC[C@@H](/C=C/[C@H]1O[C@H]2C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O2)O DSNBHJFQCNUKMA-SCKDECHMSA-N
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Cxcl6 Peptide - -
A (Rhodopsin) Somatostatin SSR5 SST5 Human Srif-28 1 Peptide - GGYTXJNZMFRSLX-DFTNLTQTSA-N 9.2 9.8 10.3 Refs
A (Rhodopsin) Adren ADA1A α1A Human (-)-Noradrenaline None 2 Small molecule NC[C@@H](c1ccc(c(c1)O)O)O SFLSHLFXELFNJZ-QMMMGPOBSA-N 5.5 7.1 8.6 4.8 5.6 6.4 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Rat Udp-Galactose None 2 Small molecule OC[C@H]1O[C@H](OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2ccc(=O)[nH]c2=O)O)O)[C@@H]([C@H]([C@H]1O)O)O HSCJRCZFDFQWRP-ABVWGUQPSA-N 7.6 7.6 Refs
A (Rhodopsin) Leukotriene OXER1 OXE Human 5-Oxo-15-Hete None 3 Small molecule CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O RIUDRKHGFDAKPO-WWWYWCMOSA-N 7.7 7.7 Refs
A (Rhodopsin) Neuromedin U NMUR2 NMU2 Human Neuromedin U-25 2 Peptide - - 8.4 8.9 9.4 9.6 9.6 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Human Galanin 2 Peptide - CBSXZYWGVAQSHI-RUKUCZSXSA-N 7.2 7.2 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide B-29 5 Peptide - -
A (Rhodopsin) P2Y P2Y14 P2Y14 Rat Udp-Glucuronic Acid None 4 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(O[C@H]2O[C@H](C(=O)O)[C@H]([C@@H]([C@H]2O)O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O HDYANYHVCAPMJV-LXQIFKJMSA-N 7.0 7.0 Refs
A (Rhodopsin) Class A orphan MRGX2 MRGPRX2 Human Pamp-20 Principal 1 Peptide - - Refs
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM3 M3 Rat Acetylcholine Principal 1 Small molecule CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 4.5 5.6 5.6 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Neuropeptide Af 3 Peptide - -
A (Rhodopsin) Adren ADA1D α1D Human (-)-Adrenaline None 1 Small molecule CNC[C@@H](c1ccc(c(c1)O)O)O UCTWMZQNUQWSLP-VIFPVBQESA-N 6.7 7.2 7.7 5.3 6.3 6.3 Refs
A (Rhodopsin) GPR18, GPR55 and GPR119 GP119 GPR119 Human Sea None 2 Small molecule CCCCCCCCCCCCCCCCCC(=O)NCCO OTGQIQQTPXJQRG-UHFFFAOYSA-N
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Cxcl10 9 Peptide - -
A (Rhodopsin) 5-Hydroxytryptamine 5HT1A 5-HT1A Human 5-Hydroxytryptamine Principal 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 9.1 9.4 9.7 Refs
B1 (Secretin) Calcitonin CALCR CT Human Adrenomedullin 5 Peptide - - 6.7 7.2 7.7 Refs
F (Frizzled) Frizzled FZD6 FZD6 Human Wnt-4 Peptide - - Refs
A (Rhodopsin) Oxoglutarate OXGR1 oxoglutarate Human Α-Ketoglutaric Acid Principal 1 Small molecule OC(=O)CCC(=O)C(=O)O KPGXRSRHYNQIFN-UHFFFAOYSA-N 3.3 3.9 4.5 Refs
A (Rhodopsin) Kisspeptin KISSR kisspeptin Human Kisspeptin-14 3 Peptide - - 8.8 8.8 Refs
A (Rhodopsin) Bile acid GPBAR GPBA Human Lithocholic Acid None 1 Small molecule O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C SMEROWZSTRWXGI-HVATVPOCSA-N 7.5 7.5 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR3 LPA3 Human Farnesyl Diphosphate None 2 Small molecule C/C(=C/COP(=O)(OP(=O)(O)O)O)/CC/C=C(\CCC=C(C)C)/C VWFJDQUYCIWHTN-FBXUGWQNSA-N Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Human Ltc4 None 2 Small molecule CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N GWNVDXQDILPJIG-NXOLIXFESA-N 7.8 9.1 9.1 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1F 5-HT1F Human 5-Hydroxytryptamine Principal 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 7.7 7.9 8.0 Refs
A (Rhodopsin) Melanocortin MC3R MC3 Human Agouti-Related Protein 3 Peptide - - Refs
A (Rhodopsin) Bradykinin BKRB2 B2 Mouse Bradykinin 1 Peptide - QXZGBUJJYSLZLT-FDISYFBBSA-N Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl4 5 Peptide - - 7.1 7.5 7.8 Refs
A (Rhodopsin) Somatostatin SSR4 SST4 Rat Srif-14 2 Peptide - VVEJUSYNERNRME-XGFVQVCISA-N 8.4 8.9 9.3 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Qrfp43 (43rfa) 3 Peptide - -
C (Glutamate) Class C Orphan GPC6A GPRC6 Human Glycine None 4 Small molecule NCC(=O)O DHMQDGOQFOQNFH-UHFFFAOYSA-N 3.6 3.6 Refs
A (Rhodopsin) Histamine HRH1 H1 Human Histamine Principal 1 Small molecule NCCc1cnc[nH]1 NTYJJOPFIAHURM-UHFFFAOYSA-N 4.7 5.3 5.9 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Prrp-31 3 Peptide - -
A (Rhodopsin) Prostanoid PD2R2 DP2 Mouse Pgj2 None 3 Small molecule CCCCC[C@@H](/C=C/[C@@H]1[C@@H](C/C=C\CCCC(=O)O)C=CC1=O)O UQOQENZZLBSFKO-POPPZSFYSA-N 7.3 7.3 Refs
A (Rhodopsin) Leukotriene LT4R2 BLT2 Human 15s-Hete None 2 Small molecule CCCCC[C@@H](/C=C/C=C\C/C=C\C/C=C\CCCC(=O)O)O JSFATNQSLKRBCI-VAEKSGALSA-N 7.5 7.5 Refs
A (Rhodopsin) Adren ADRB3 β3 Rat (-)-Noradrenaline None 1 Small molecule NC[C@@H](c1ccc(c(c1)O)O)O SFLSHLFXELFNJZ-QMMMGPOBSA-N 7.2 7.2 4.7 3.8 3.8 Refs
A (Rhodopsin) Class A orphan TAAR2 TAAR2 Human Tryptamine Small molecule NCCc1c[nH]c2c1cccc2 APJYDQYYACXCRM-UHFFFAOYSA-N
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl4 Peptide - -
A (Rhodopsin) Cannabinoid CNR1 CB1 Human 2-Arachidonoylglycerol None 1 Small molecule CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)OC(CO)CO RCRCTBLIHCHWDZ-DOFZRALJSA-N
A (Rhodopsin) Bombesin GRPR BB2 Rat Neuromedin B 2 Peptide - YPFNACALNKVZNK-UHFFFAOYSA-N 6.6 7.0 7.4 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Human Udp N-Acetyl-Glucosamine None 5 Small molecule OC[C@H]1O[C@H](OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2ccc(=O)[nH]c2=O)O)O)[C@@H]([C@H]([C@@H]1O)O)NC(=O)C LFTYTUAZOPRMMI-CFRASDGPSA-N
A (Rhodopsin) Complement peptide C5AR2 C5a2 Human C5a Des-Arg 2 Peptide - - 8.6 8.6 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Gastrin-17 5 Peptide - -
C (Glutamate) Calcium-sensing CASR CaS Human Ca2+ None 2 Small molecule - - Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR5 LPA5 Human Lpa None 3 Small molecule CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O WRGQSWVCFNIUNZ-KTKRTIGZSA-N 4.3 6.1 7.9 Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Humanin 4 Peptide - DPEUWKZJZIPZKE-OFANTOPUSA-N 8.5 8.5 Refs
A (Rhodopsin) Class A orphan GPR34 GPR34 Human Lysophosphatidylserine Principal 1 Small molecule CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OC[C@@H](C(=O)O)N)O)O ZPDQFUYPBVXUKS-YADHBBJMSA-N 6.6 7.3 7.3 Refs
A (Rhodopsin) Dopamine DRD2 D2 Rat Dopamine Principal 1 Small molecule NCCc1ccc(c(c1)O)O VYFYYTLLBUKUHU-UHFFFAOYSA-N 4.7 6.0 7.2 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Rat Galanin 2 Peptide - - 8.1 8.5 8.8 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide W-23 1 Peptide - - Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Human Bradykinin 4 Peptide - QXZGBUJJYSLZLT-FDISYFBBSA-N 5.1 5.2 5.3 Refs
A (Rhodopsin) Vasopressin and oxytocin OXYR OT Human Vasopressin 2 Peptide - KBZOIRJILGZLEJ-LGYYRGKSSA-N 7.3 8.3 9.3 Refs
A (Rhodopsin) Chemokine CXCR4 CXCR4 Human Cxcl12Δ 3 Peptide - - Refs
A (Rhodopsin) Free fatty acid FFAR4 FFA4 Human Oleic Acid None 4 Small molecule CCCCCCCC/C=C\CCCCCCCC(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 4.7 4.7 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide W-23 5 Peptide - -
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Ccl19 8 Peptide - - 5.9 5.9 Refs
A (Rhodopsin) P2Y P2Y13 P2Y13 Human Atp None 2 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N ZKHQWZAMYRWXGA-KQYNXXCUSA-N Refs
A (Rhodopsin) Apelin APJ apelin Human Apelin Receptor Early Endogenous Ligand 1 Peptide - - Refs
A (Rhodopsin) Proteinase-activated PAR1 PAR1 Human Thrombin Principal 1 Peptide - -
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Fmet-Leu-Phe None 9 Peptide - PRQROPMIIGLWRP-BZSNNMDCSA-N
A (Rhodopsin) 5-Hydroxytryptamine 5HT2A 5-HT2A Human Tryptamine None 2 Small molecule NCCc1c[nH]c2c1cccc2 APJYDQYYACXCRM-UHFFFAOYSA-N 5.5 6.6 7.6 Refs
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Pth 5 Peptide - -
A (Rhodopsin) Prostanoid PE2R3 EP3 Human Pgi2 4 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O KAQKFAOMNZTLHT-OZUDYXHBSA-N
A (Rhodopsin) Chemokine CCRL2 CCRL2 Human Ccl19 1 Peptide - - Refs
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C3a 2 Peptide - -
C (Glutamate) Metabotropic glutamate GRM2 mGlu2 Rat L-Glutamic Acid Principal 1 Small molecule OC(=O)CC[C@@H](C(=O)O)N WHUUTDBJXJRKMK-VKHMYHEASA-N 4.7 5.1 5.4 5.4 5.7 5.9 Refs
A (Rhodopsin) Opioid OPRK κ Mouse Α-Neoendorphin 3 Peptide - KZTDMJBCZSGHOG-XJIZABAQSA-N 8.3 9.3 10.2 Refs
C (Glutamate) Calcium-sensing CASR CaS Mouse Ca2+ None 2 Small molecule - - Refs
A (Rhodopsin) Chemokine CXCR4 CXCR4 Human Cxcl12Φ 3 Peptide - - Refs
A (Rhodopsin) Opioid OPRK κ Human Dynorphin B 5 Peptide - AGTSSZRZBSNTGQ-ITZCFHCWSA-N 8.1 9.0 9.9 Refs
A (Rhodopsin) Class A orphan LGR4 LGR4 Human R-Spondin-3 2 Peptide - - 10.7 10.7 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Human Phm 4 Peptide - -
A (Rhodopsin) P2Y P2Y14 P2Y14 Human Udp None 3 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O XCCTYIAWTASOJW-XVFCMESISA-N 7.1 7.1 Refs
A (Rhodopsin) Free fatty acid FFAR4 FFA4 Human Α-Linolenic Acid None 2 Small molecule CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O DTOSIQBPPRVQHS-PDBXOOCHSA-N 5.5 5.5 Refs
Other GPCRs Other GPCR orphan GP107 GPR107 Human Neuronostatin Principal 1 Peptide - QMXYKUFZQPEQES-UZSBMYCGSA-N
A (Rhodopsin) Opioid OPRK κ Mouse Dynorphin A-(1-8) 6 Peptide - WRPLGMBDXVBPEG-VGXZEHLRSA-N 8.0 9.0 9.9 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl3 3 Peptide - - Refs
A (Rhodopsin) Apelin APJ apelin Human Apelin-36 2 Peptide - NRXGOOSANFUBIE-ZINMNJNTSA-N
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl3 8 Peptide - -
A (Rhodopsin) Lysophospholipid (S1P) S1PR4 S1P4 Human Dihydrosphingosine 1-Phosphate None 2 Small molecule CCCCCCCCCCCCCCC[C@H]([C@H](COP(=O)(O)O)N)O YHEDRJPUIRMZMP-ZWKOTPCHSA-N
F (Frizzled) Frizzled FZD1 FZD1 Human Wnt-2 Peptide - -
A (Rhodopsin) Leukotriene CLTR2 CysLT2 Human Ltc4 None 1 Small molecule CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N GWNVDXQDILPJIG-NXOLIXFESA-N 7.0 7.6 8.6 Refs
A (Rhodopsin) Succinate SUCR1 succinate Human Succinic Acid Principal 1 Small molecule OC(=O)CCC(=O)O KDYFGRWQOYBRFD-UHFFFAOYSA-N 3.1 3.9 4.7 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR1 CRF1 Human Urocortin 2 3 Peptide - PIXFIEBACLDPNF-SKCWXFKWSA-N Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Cxcl12Α 7 Peptide - - 6.4 6.4 Refs
A (Rhodopsin) Leukotriene LT4R2 BLT2 Human Ltb4 None 3 Small molecule CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O VNYSSYRCGWBHLG-AMOLWHMGSA-N 6.8 6.8 Refs
B1 (Secretin) Calcitonin CALCR CT Human Amylin 3 Peptide - - 8.0 8.6 9.2 Refs
A (Rhodopsin) Glycoprotein hormone FSHR FSH Human Fsh Principal 1 Peptide - -
A (Rhodopsin) Class A orphan GPR17 GPR17 Human Ltd4 None 3 Small molecule CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N YEESKJGWJFYOOK-LDDGIIIKSA-N 8.1 8.3 8.4 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Cxcl9 5 Peptide - -
A (Rhodopsin) Lysophospholipid (LPA) LPAR2 LPA2 Mouse Lpa None 1 Small molecule CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O WRGQSWVCFNIUNZ-KTKRTIGZSA-N 6.7 7.5 8.2 Refs
A (Rhodopsin) Neurotensin NTR1 NTS1 Human Large Neurotensin 3 Peptide - - Refs
A (Rhodopsin) Prokineticin PKR2 PKR2 Human Prokineticin-2 1 Peptide - - Refs
A (Rhodopsin) P2Y P2RY4 P2Y4 Human Utp None 1 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O PGAVKCOVUIYSFO-XVFCMESISA-N 6.3 6.3 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl2 8 Peptide - -
A (Rhodopsin) Chemokine CCR10 CCR10 Human Ccl28 Peptide - -
A (Rhodopsin) Prostanoid PE2R4 EP4 Rat Pgf2Α None 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O PXGPLTODNUVGFL-YNNPMVKQSA-N 6.1 6.1 9.1 9.3 9.5 Refs
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM4 M4 Human Acetylcholine Principal 1 Small molecule CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 4.5 5.1 5.6 Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human 15-Deoxy-Lxa4 9 Small molecule CCCCCC/C=C/C=C/C=C/C=C/[C@H]([C@H](CCCC(=O)O)O)O SJIRTDBAYKOBAL-COJKCNNISA-N
A (Rhodopsin) Neuropeptide Y NPY2R Y2 Human Pancreatic Polypeptide 5 Peptide - -
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl11 8 Peptide - -
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Neuropeptide Af 3 Peptide - -
A (Rhodopsin) Opioid OPRM μ Human Dynorphin A-(1-13) 4 Peptide - OVVIBUHLQIYUEU-IWIISZHXSA-N 8.3 8.3 Refs
A (Rhodopsin) Chemokine CCR8 CCR8 Human Ccl1 1 Peptide - - Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide B-29 3 Peptide - - Refs
A (Rhodopsin) Opioid OPRD δ Human Β-Endorphin 7 Peptide - HQALISCIMNBRAE-XJTHNYJFSA-N
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Ccl5 Peptide - -
A (Rhodopsin) Class A orphan GPR35 GPR35 Human Kynurenic Acid None 2 Small molecule OC(=O)c1cc(=O)c2c([nH]1)cccc2 HCZHHEIFKROPDY-UHFFFAOYSA-N 3.9 5.0 5.0 Refs
A (Rhodopsin) Melanocortin MSHR MC1 Mouse Agouti 2 Peptide - - Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide W-30 5 Peptide - -
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl7 7 Peptide - -
A (Rhodopsin) Adren ADA2C α2C Human (-)-Noradrenaline None 2 Small molecule NC[C@@H](c1ccc(c(c1)O)O)O SFLSHLFXELFNJZ-QMMMGPOBSA-N 6.0 6.8 7.7 4.5 5.7 6.8 Refs
A (Rhodopsin) Free fatty acid FFAR1 FFA1 Human Docosahexaenoic Acid None 1 Small molecule CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O MBMBGCFOFBJSGT-KUBAVDMBSA-N 5.4 5.7 6.0 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Cxcl11 5 Peptide - -
B1 (Secretin) Calcitonin CALCR CT Human Adrenomedullin 2/Intermedin 6 Peptide - - 6.5 6.5 Refs
B2 (Adhesion) ADGRL AGRL1 ADGRL1 Human Lasso D Principal 1 Peptide - -
B1 (Secretin) VIP and PACAP PACR PAC1 Human Pacap-38 1 Peptide - - 9.5 9.8 10.0 6.9 8.2 9.0 Refs
B1 (Secretin) Parathyroid hormone PTH1R PTH1 Human Pth 3 Peptide - -
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl5 5 Peptide - -
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Desulfated Gastrin-14 5 Peptide - -
A (Rhodopsin) Dopamine DRD4 D4 Human Dopamine Principal 1 Small molecule NCCc1ccc(c(c1)O)O VYFYYTLLBUKUHU-UHFFFAOYSA-N 7.6 7.6 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Rat Srif-28 3 Peptide - GGYTXJNZMFRSLX-DFTNLTQTSA-N 8.1 9.0 9.9 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl7 3 Peptide - - 8.6 8.9 9.2 Refs
A (Rhodopsin) Adren ADRB3 β3 Human (-)-Noradrenaline None 1 Small molecule NC[C@@H](c1ccc(c(c1)O)O)O SFLSHLFXELFNJZ-QMMMGPOBSA-N 7.2 7.2 4.7 3.8 3.8 Refs
A (Rhodopsin) Tachykinin NK1R NK1 Human Neurokinin B 3 Peptide - NHXYSAFTNPANFK-HDMCBQFHSA-N 6.1 6.3 6.4 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Neuropeptide Af 3 Peptide - -
A (Rhodopsin) Chemokine CXCR4 CXCR4 Human Cxcl12 3 Peptide - -
A (Rhodopsin) Melanin-concentrating hormon MCHR1 MCH1 Rat Melanin-Concentrating Hormone Principal 1 Peptide - ORRDHOMWDPJSNL-UHFFFAOYSA-N 9.8 9.9 10.0 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl8 3 Peptide - - Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Rfrp-1 3 Peptide - -
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C5a 1 Peptide - - 8.0 8.5 9.0 Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Ltd4 9 Small molecule CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N YEESKJGWJFYOOK-LDDGIIIKSA-N
A (Rhodopsin) Histamine HRH4 H4 Rat Histamine None 1 Small molecule NCCc1cnc[nH]1 NTYJJOPFIAHURM-UHFFFAOYSA-N 7.8 7.4 7.4 Refs
A (Rhodopsin) Relaxin family peptide RXFP1 RXFP1 Human Relaxin-1 2 Peptide - - 8.8 8.8 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1F 5-HT1F Rat 5-Hydroxytryptamine Principal 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 7.7 7.9 8.0 Refs
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Rat Neuropeptide Y 1 Peptide - XKWCTHKJQNUFOQ-HRPSIEBRSA-N 9.3 9.3 Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Cxcl9 9 Peptide - -
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl3 Peptide - -
A (Rhodopsin) Chemokine XCR1 XCR1 Human Xcl1 1 Peptide - - 7.3 7.3 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1B 5-HT1B Human Tryptamine None 2 Small molecule NCCc1c[nH]c2c1cccc2 APJYDQYYACXCRM-UHFFFAOYSA-N 6.3 6.3 Refs
A (Rhodopsin) Prokineticin PKR2 PKR2 Human Prokineticin-1 4 Peptide - -
A (Rhodopsin) Prokineticin PKR1 PKR1 Human Prokineticin-2Β 2 Peptide - - Refs
B1 (Secretin) Glucagon receptor family GLP2R GLP-2 Human Glucagon-Like Peptide 2-(3-33) 4 Peptide - FGSZUMQGXARWAJ-XVADTHAUSA-N
A (Rhodopsin) Melanocortin MC3R MC3 Human Β-Msh 3 Peptide - -
A (Rhodopsin) Prostanoid PD2R DP1 Human Pgd2 None 2 Small molecule CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O BHMBVRSPMRCCGG-OUTUXVNYSA-N 7.8 7.6 7.6 Refs
A (Rhodopsin) Opioid OPRK κ Rat Dynorphin B 5 Peptide - AGTSSZRZBSNTGQ-ITZCFHCWSA-N 8.1 9.0 9.9 Refs
A (Rhodopsin) Class A orphan GPR34 GPR34 Mouse Lysophosphatidylserine Principal 1 Small molecule CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OC[C@@H](C(=O)O)N)O)O ZPDQFUYPBVXUKS-YADHBBJMSA-N 6.6 7.3 7.3 Refs
A (Rhodopsin) Endothelin EDNRB ETB Rat Endothelin-3 1 Peptide - - Refs
A (Rhodopsin) P2Y P2RY2 P2Y2 Human Atp None 2 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N ZKHQWZAMYRWXGA-KQYNXXCUSA-N 6.6 6.9 7.1 Refs
A (Rhodopsin) Tachykinin NK3R NK3 Mouse Neurokinin B 1 Peptide - NHXYSAFTNPANFK-HDMCBQFHSA-N 8.4 8.4 7.7 8.5 9.2 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl5 3 Peptide - -
A (Rhodopsin) Neurotensin NTR2 NTS2 Human Neurotensin 1 Peptide - PCJGZPGTCUMMOT-ISULXFBGSA-N 8.8 8.8 Refs
A (Rhodopsin) Bombesin GRPR BB2 Human Grp-(18-27) 3 Peptide - -
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Human Pancreatic Polypeptide 2 Peptide - - 8.7 9.8 10.9 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl11 8 Peptide - -
A (Rhodopsin) Somatostatin SSR3 SST3 Human Cst-17 2 Peptide - - 8.7 9.3 9.9 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR3 LPA3 Human Lpa None 1 Small molecule CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O WRGQSWVCFNIUNZ-KTKRTIGZSA-N 6.6 6.6 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Pgi2 None 5 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O KAQKFAOMNZTLHT-OZUDYXHBSA-N 4.8 4.8 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Human Thromboxane A2 5 Small molecule CCCCC[C@@H](/C=C/[C@H]1O[C@H]2C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O2)O DSNBHJFQCNUKMA-SCKDECHMSA-N
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Pgi2 None 4 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O KAQKFAOMNZTLHT-OZUDYXHBSA-N 5.1 5.1 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Gastrin-34 5 Peptide - -
A (Rhodopsin) Bombesin NMBR BB1 Human Gastrin-Releasing Peptide 2 Peptide - BNEIPTFKHBHJBM-XKNFJVFFSA-N
A (Rhodopsin) Leukotriene LT4R2 BLT2 Human 12s-Hete None 2 Small molecule CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)O ZNHVWPKMFKADKW-LQWMCKPYSA-N 7.5 7.5 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl11 6 Peptide - - Refs
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Cxcl8 Peptide - -
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl13 7 Peptide - -
B2 (Adhesion) ADGRB AGRB1 ADGRB1 Human Phosphatidylserine Principal 1 Small molecule CCCC(=O)O[C@@H](COP(=O)(OC[C@@H](C(=O)O)N)O)COC(=O)CC UNJJBGNPUUVVFQ-ZJUUUORDSA-N Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Pgd2 None 4 Small molecule CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O BHMBVRSPMRCCGG-OUTUXVNYSA-N 5.2 5.2 Refs
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Annexin I 2 Peptide - -
A (Rhodopsin) Prokineticin PKR2 PKR2 Human Prokineticin-1 2 Peptide - - Refs
A (Rhodopsin) Chemokine CXCR6 CXCR6 Human Cxcl16 Principal 1 Peptide - -
A (Rhodopsin) Class A orphan GPR63 GPR63 Human Dioleoylphosphatidic Acid None 1 Small molecule CCCCCCCC/C=C\CCCCCCCC(=O)OCC(OC(=O)CCCCCCC/C=C\CCCCCCCC)COP(=O)(O)O MHUWZNTUIIFHAS-CLFAGFIQSA-N 6.3 6.3 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Phi 4 Peptide - -
A (Rhodopsin) Prostanoid PD2R2 DP2 Human Pge2 None 5 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O XEYBRNLFEZDVAW-ARSRFYASSA-N 5.3 5.3 Refs
A (Rhodopsin) Cannabinoid CNR2 CB2 Human 2-Arachidonoylglycerol None 1 Small molecule CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)OC(CO)CO RCRCTBLIHCHWDZ-DOFZRALJSA-N 5.8 6.3 6.8 Refs
A (Rhodopsin) Bombesin NMBR BB1 Human Grp-(18-27) 2 Peptide - -
A (Rhodopsin) Class A orphan GP183 GPR183 Human 25-Hydroxycholesterol None 6 Small molecule O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)C1)C INBGSXNNRGWLJU-ZHHJOTBYSA-N 6.9 6.9 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Desulfated Gastrin-71 5 Peptide - -
A (Rhodopsin) Leukotriene CLTR2 CysLT2 Human Lte4 None 3 Small molecule CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N OTZRAYGBFWZKMX-FRFVZSDQSA-N 5.6 6.3 7.1 6.5 6.5 Refs
A (Rhodopsin) Neurotensin NTR1 NTS1 Human Neurotensin 1 Peptide - PCJGZPGTCUMMOT-ISULXFBGSA-N 8.2 9.1 10.0 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR6 LPA6 Mouse Lpa Principal 1 Small molecule CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O WRGQSWVCFNIUNZ-KTKRTIGZSA-N 6.0 6.0 Refs
A (Rhodopsin) Chemokine ACKR3 ACKR3 Human Cxcl12Α 1 Peptide - - 7.5 7.7 7.9 Refs
B1 (Secretin) Glucagon receptor family GLP2R GLP-2 Human Glucagon-Like Peptide 2-(3-33) 4 Peptide - MYKFSDGCGNRIEA-KXTJMAPWSA-N Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Rfrp-3 2 Peptide - - 7.8 7.8 Refs
A (Rhodopsin) Galanin GALR2 GAL2 Human Galanin-Like Peptide 4 Peptide - -
A (Rhodopsin) Chemokine CXCR4 CXCR4 Human Cxcl12Ε 3 Peptide - - Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Β-Msh 2 Peptide - -
A (Rhodopsin) GPR18, GPR55 and GPR119 GP119 GPR119 Human N-Palmitoylethanolamine None 2 Small molecule CCCCCCCCCCCCCCCC(=O)NCCO HXYVTAGFYLMHSO-UHFFFAOYSA-N
A (Rhodopsin) Chemerin CML2 chemerin 2 Human Chemerin Principal 1 Peptide - - 8.8 9.2 9.6 Refs
A (Rhodopsin) Platelet-activating factor PTAFR PAF Human Paf Principal 1 Small molecule CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] HVAUUPRFYPCOCA-AREMUKBSSA-N 7.5 7.7 7.9 Refs
A (Rhodopsin) Tachykinin NK2R NK2 Human Neuropeptide K 4 Peptide - -
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Secretin 4 Peptide - -
A (Rhodopsin) Hydroxycarboxylic acid HCAR1 HCA1 Mouse L-Lactic Acid Principal 1 Small molecule OC(=O)[C@@H](O)C JVTAAEKCZFNVCJ-REOHCLBHSA-N 1.3 2.1 2.9 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Phm 4 Peptide - - 5.7 5.7 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Rat 3-Iodothyronamine None 1 Small molecule NCCc1ccc(cc1)Oc1ccc(c(c1)I)O HCYGDNGLWSZCCA-UHFFFAOYSA-N 7.5 7.7 7.9 Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Mouse Lte4 None 1 Small molecule CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N OTZRAYGBFWZKMX-FRFVZSDQSA-N 9.5 9.5 Refs
A (Rhodopsin) Adren ADRB3 β3 Mouse (-)-Noradrenaline None 1 Small molecule NC[C@@H](c1ccc(c(c1)O)O)O SFLSHLFXELFNJZ-QMMMGPOBSA-N 7.2 7.2 4.7 3.8 3.8 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Pacap-38 1 Peptide - - 7.7 8.5 9.3 Refs
A (Rhodopsin) Adenosine AA3R A3 Rat Adenosine Principal 1 Small molecule OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N OIRDTQYFTABQOQ-KQYNXXCUSA-N 6.5 6.5 Refs
A (Rhodopsin) Melatonin MTR1B MT2 Human Melatonin Principal 1 Small molecule COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 DRLFMBDRBRZALE-UHFFFAOYSA-N 9.4 9.6 9.8 Refs
A (Rhodopsin) Class A orphan GPR39 GPR39 Human Zn2+ None Small molecule [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N Refs
A (Rhodopsin) Opioid OPRX NOP Human Nociceptin/Orphanin Fq Principal 1 Peptide - PULGYDLMFSFVBL-SMFNREODSA-N 8.4 9.1 9.8 9.7 9.4 9.4 Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Mouse Udp-Galactose None 5 Small molecule OC[C@H]1O[C@H](OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2ccc(=O)[nH]c2=O)O)O)[C@@H]([C@H]([C@H]1O)O)O HSCJRCZFDFQWRP-ABVWGUQPSA-N 6.0 7.5 8.9 Refs
A (Rhodopsin) Neurotensin NTR2 NTS2 Mouse Xenin 2 Peptide - IDHVLSACPFUBDY-QCDLPZBNSA-N Refs
A (Rhodopsin) Relaxin family peptide RL3R2 RXFP4 Human Relaxin-3 (B Chain) 4 Peptide - - 7.0 7.0 Refs
A (Rhodopsin) Melatonin MTR1A MT1 Human Melatonin Principal 1 Small molecule COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 DRLFMBDRBRZALE-UHFFFAOYSA-N 9.1 9.4 9.7 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl16 8 Peptide - -
A (Rhodopsin) Opioid OPRD δ Mouse Α-Neoendorphin 7 Peptide - KZTDMJBCZSGHOG-XJIZABAQSA-N Refs
A (Rhodopsin) Class A orphan TAAR2 TAAR2 Human Β-Phenylethylamine Small molecule NCCc1ccccc1 BHHGXPLMPWCGHP-UHFFFAOYSA-N
A (Rhodopsin) Peptide P518 QRFPR QRFP Human Qrfp26 (26rfa) 2 Peptide - - 8.1 8.1 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR2 S1P2 Human Dihydrosphingosine 1-Phosphate 2 Small molecule CCCCCCCCCCCCCCC[C@H]([C@H](COP(=O)(O)O)N)O YHEDRJPUIRMZMP-ZWKOTPCHSA-N
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Cck-58 2 Peptide - -
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Mouse Peptide Yy 5 Peptide - IXMRLEGHWROJAA-HDTKZREISA-N 6.3 7.0 8.5 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Rat Udp None 3 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O XCCTYIAWTASOJW-XVFCMESISA-N 7.1 7.1 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT5A 5-HT5A Mouse 5-Hydroxytryptamine Principal 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 6.0 6.3 6.6 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide B-23 5 Peptide - -
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Ghrh 4 Peptide - -
A (Rhodopsin) Chemokine CCRL2 CCRL2 Human Ccl19 2 Peptide - -
A (Rhodopsin) Class A orphan GPR87 GPR87 Human Lpa Principal 1 Small molecule CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O WRGQSWVCFNIUNZ-KTKRTIGZSA-N 7.4 7.4 Refs
A (Rhodopsin) Apelin APJ apelin Human Elabela/Toddler-21 2 Peptide - TXSAAXFWNUKYQL-FMGZCOAKSA-N
A (Rhodopsin) Class A orphan GPR17 GPR17 Mouse Ltd4 None 3 Small molecule CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N YEESKJGWJFYOOK-LDDGIIIKSA-N 8.1 8.3 8.4 Refs
A (Rhodopsin) Relaxin family peptide RXFP2 RXFP2 Human Relaxin 1 Peptide - - 9.1 9.1 8.3 8.4 8.5 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Mouse Corticotrophin-Releasing Hormone 1 Peptide - - 7.8 7.8 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Human Galanin-Like Peptide 2 Peptide - -
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl7 5 Peptide - -
A (Rhodopsin) Complement peptide C3AR C3a Human C5a 2 Peptide - -
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Secretin 4 Peptide - -
A (Rhodopsin) Urotensin UR2R UT Mouse Urotensin-Ii 3 Peptide - - 8.4 8.5 8.6 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide W-30 1 Peptide - - Refs
A (Rhodopsin) Opioid OPRK κ Human Β-Endorphin 9 Peptide - HQALISCIMNBRAE-XJTHNYJFSA-N
B1 (Secretin) Calcitonin CALCR CT Human Α-Cgrp 4 Peptide - - 6.2 7.3 8.4 Refs
A (Rhodopsin) Angiotensin AGTR2 AT2 Human Angiotensin Iii 1 Peptide - UCRMCWFIVZYPFA-LGXQCQDRSA-N Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Cxcl10 5 Peptide - -
A (Rhodopsin) Relaxin family peptide RXFP1 RXFP1 Human Relaxin 1 Peptide - - 10.4 10.4 9.2 9.7 10.2 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Pge1 None 2 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O GMVPRGQOIOIIMI-DWKJAMRDSA-N 7.4 7.4 Refs
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Rat Tip39 2 Peptide - - Refs
A (Rhodopsin) Adenosine AA2BR A2B Human Adenosine Principal 1 Small molecule OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N OIRDTQYFTABQOQ-KQYNXXCUSA-N 4.8 4.8 Refs
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Cathepsin G 2 Peptide - -
A (Rhodopsin) Prostanoid PE2R3 EP3 Human Thromboxane A2 4 Small molecule CCCCC[C@@H](/C=C/[C@H]1O[C@H]2C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O2)O DSNBHJFQCNUKMA-SCKDECHMSA-N
A (Rhodopsin) Relaxin family peptide RL3R2 RXFP4 Human Relaxin-3 1 Peptide - - 8.7 9.2 9.7 8.8 8.9 9.0 Refs
A (Rhodopsin) Proteinase-activated PAR1 PAR1 Human Thrombin Principal 1 Peptide - -
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl2 8 Peptide - -
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide B-23 5 Peptide - -
A (Rhodopsin) Neuromedin U NMUR2 NMU2 Human Neuromedin S-36 3 Peptide - -
A (Rhodopsin) Cannabinoid CNR1 CB1 Rat 2-Arachidonoylglycerol None 1 Small molecule CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)OC(CO)CO RCRCTBLIHCHWDZ-DOFZRALJSA-N 6.3 6.8 7.2 Refs
A (Rhodopsin) Prostanoid PD2R DP1 Mouse Pgd2 None 2 Small molecule CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O BHMBVRSPMRCCGG-OUTUXVNYSA-N 7.8 7.6 7.6 Refs
A (Rhodopsin) Neuromedin U NMUR1 NMU1 Human Neuromedin S-36 3 Peptide - -
A (Rhodopsin) Bradykinin BKRB1 B1 Human [Hyp3]Bradykinin 6 Peptide - -
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Desulfated Gastrin-34 5 Peptide - DKONFPYEAKZHHO-JCVYGFDXSA-N
A (Rhodopsin) Class A orphan GPR37 GPR37 Human Prosaptide Principal 1 Peptide - KSDDQEGWVBODMD-OULINLAESA-N 8.1 8.1 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Rat Pacap-27 2 Peptide - RZGBUJXSKLDAFE-UHFFFAOYSA-N 7.6 8.6 9.9 8.9 8.9 Refs
A (Rhodopsin) Class A orphan LGR6 LGR6 Human R-Spondin-1 Peptide - - Refs
A (Rhodopsin) Class A orphan TAAR3 TAAR3 Human Isoamylamine Principal 1 Small molecule NCCC(C)C BMFVGAAISNGQNM-UHFFFAOYSA-N
A (Rhodopsin) Chemokine CCR3 CCR3 Human Cxcl10 5 Peptide - -
B1 (Secretin) Calcitonin CALCR CT Human Β-Cgrp 7 Peptide - -
A (Rhodopsin) Bradykinin BKRB2 B2 Human Lys-[Hyp3]-Bradykinin 3 Peptide - -
A (Rhodopsin) GPR18, GPR55 and GPR119 GPR55 GPR55 Human 2-Arachidonoylglycerolphosphoinositol None 5 Small molecule CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)OC(COP(=O)(OC1C(O)C(O)C(C(C1O)O)O)[O-])CO OKEQUIXTUXJQNT-DOFZRALJSA-M Refs
A (Rhodopsin) Class A orphan GPR63 GPR63 Human Dihydrosphingosine 1-Phosphate None 2 Small molecule CCCCCCCCCCCCCCC[C@H]([C@H](COP(=O)(O)O)N)O YHEDRJPUIRMZMP-ZWKOTPCHSA-N 6.2 6.2 Refs
A (Rhodopsin) Relaxin family peptide RL3R1 RXFP3 Human Insl5 3 Peptide - - 7.0 7.0 Refs
A (Rhodopsin) Melanocortin ACTHR MC2 Human Acth Principal 1 Peptide - IDLFZVILOHSSID-OVLDLUHVSA-N
A (Rhodopsin) P2Y P2Y12 P2Y12 Human Atp 2 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N ZKHQWZAMYRWXGA-KQYNXXCUSA-N
A (Rhodopsin) Adren ADRB3 β3 Mouse (-)-Adrenaline None 3 Small molecule CNC[C@@H](c1ccc(c(c1)O)O)O UCTWMZQNUQWSLP-VIFPVBQESA-N
C (Glutamate) Calcium-sensing CASR CaS Human L-Tryptophan None 1 Small molecule OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N QIVBCDIJIAJPQS-VIFPVBQESA-N Refs
A (Rhodopsin) Chemokine CCR4 CCR4 Human Ccl22 3 Peptide - -
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C3a 2 Peptide - -
A (Rhodopsin) Opioid OPRM μ Human Dynorphin B 2 Peptide - AGTSSZRZBSNTGQ-ITZCFHCWSA-N 8.5 8.5 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl1 3 Peptide - -
A (Rhodopsin) P2Y P2RY2 P2Y2 Human Utp None 1 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O PGAVKCOVUIYSFO-XVFCMESISA-N 8.1 8.1 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Human Cortistatin-14 4 Peptide - -
A (Rhodopsin) Bombesin GRPR BB2 Human Neuromedin C None 3 Peptide - - Refs
A (Rhodopsin) Bombesin GRPR BB2 Human Gastrin Releasing Peptide(14-27) (Human) None 3 Peptide - MJHJYGACUDLDMG-QEJDUTAOSA-N Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Acth 1 Peptide - IDLFZVILOHSSID-OVLDLUHVSA-N 5.0 5.0 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl4 1 Peptide - - 9.4 9.5 9.6 Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Ccl7 6 Peptide - - 6.6 6.6 Refs
A (Rhodopsin) Proteinase-activated PAR4 PAR4 Human Cathepsin G Peptide - -
A (Rhodopsin) 5-Hydroxytryptamine 5HT2A 5-HT2A Rat 5-Hydroxytryptamine None 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 6.0 7.2 8.4 Refs
A (Rhodopsin) Adren ADRB3 β3 Human (-)-Adrenaline None 2 Small molecule CNC[C@@H](c1ccc(c(c1)O)O)O UCTWMZQNUQWSLP-VIFPVBQESA-N 6.5 6.5 3.9 4.3 4.7 Refs
C (Glutamate) Metabotropic glutamate GRM1 mGlu1 Human L-Glutamic Acid Principal 1 Small molecule OC(=O)CC[C@@H](C(=O)O)N WHUUTDBJXJRKMK-VKHMYHEASA-N 4.8 4.9 5.0 6.4 6.5 6.5 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Mouse Pgd2 None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O BHMBVRSPMRCCGG-OUTUXVNYSA-N 7.4 7.5 7.5 Refs
A (Rhodopsin) Melanin-concentrating hormon MCHR1 MCH1 Human Melanin-Concentrating Hormone Principal 1 Peptide - ORRDHOMWDPJSNL-UHFFFAOYSA-N 9.8 9.9 10.0 Refs
A (Rhodopsin) Prostanoid PF2R FP Human Pgi2 4 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O KAQKFAOMNZTLHT-OZUDYXHBSA-N
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Annexin I 2 Peptide - -
A (Rhodopsin) Urotensin UR2R UT Human Urotensin Ii-Related Peptide 4 Peptide - BKBNRUZZGBUWOM-KOOAXUMWSA-N Refs
A (Rhodopsin) Leukotriene LT4R1 BLT1 Human Ltb4 None 1 Small molecule CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O VNYSSYRCGWBHLG-AMOLWHMGSA-N 9.4 9.4
A (Rhodopsin) Somatostatin SSR4 SST4 Human Cortistatin-14 4 Peptide - -
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Pth 5 Peptide - -
A (Rhodopsin) Complement peptide C3AR C3a Human C5a 2 Peptide - -
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Des-Br-Neuropeptide B-29 3 Peptide - - Refs
A (Rhodopsin) Opioid OPRM μ Human Β-Endorphin 6 Peptide - KSZMZNRVPCEDEO-KFHPFRHLSA-N
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Rat Phv 4 Peptide - - Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Mouse Udp-Glucose None 1 Small molecule OC[C@H]1O[C@H](OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2ccc(=O)[nH]c2=O)O)O)[C@@H]([C@H]([C@@H]1O)O)O HSCJRCZFDFQWRP-JZMIEXBBSA-N 7.7 7.7 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Rfrp-3 1 Peptide - - 9.2 9.3 9.3 Refs
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM3 M3 Human Acetylcholine Principal 1 Small molecule CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 4.5 5.6 5.6 Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Annexin I 9 Peptide - - Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1B 5-HT1B Human 5-Ht-Moduline None 3 Peptide - IMIVWAUMTAIVPJ-XUXIUFHCSA-N Refs
A (Rhodopsin) Angiotensin AGTR2 AT2 Human Angiotensin Ii 2 Peptide - CZGUSIXMZVURDU-JZXHSEFVSA-N
B1 (Secretin) Parathyroid hormone PTH1R PTH1 Human Pth 3 Peptide - -
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl2 3 Peptide - -
A (Rhodopsin) Formylpeptide FPR3 FPR3 Human F2l 2 Peptide - - 8.0 8.1 8.2 Refs
A (Rhodopsin) Histamine HRH4 H4 Human Ccl16 2 Peptide - - Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl24 7 Peptide - - Refs
A (Rhodopsin) Free fatty acid FFAR4 FFA4 Human Linoleic Acid None 1 Small molecule CCCCC/C=C\C/C=C\CCCCCCCC(=O)O OYHQOLUKZRVURQ-HZJYTTRNSA-N 5.9 5.9 Refs
A (Rhodopsin) Endothelin EDNRA ETA Human Endothelin-2 3 Peptide - -
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Gastrin-17 2 Peptide - -
A (Rhodopsin) Glycoprotein hormone LSHR LH Human Hcg 1 Peptide - - Refs
A (Rhodopsin) Class A orphan Q33BM1 GPR35 Rat Kynurenic Acid None 2 Small molecule OC(=O)c1cc(=O)c2c([nH]1)cccc2 HCZHHEIFKROPDY-UHFFFAOYSA-N 3.9 5.0 5.0 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Human Pgf2Α None 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O PXGPLTODNUVGFL-YNNPMVKQSA-N 5.2 5.6 6.0 Refs
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Human Pancreatic Polypeptide 6 Peptide - -
A (Rhodopsin) Bombesin NMBR BB1 Human Gastrin-Releasing Peptide 2 Peptide - -
A (Rhodopsin) Class A orphan GP183 GPR183 Human 27-Hydroxycholesterol None 8 Small molecule OC[C@@H](CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC=C2[C@]1(C)CC[C@@H](C2)O)C)C FYHRJWMENCALJY-YSQMORBQSA-N 5.5 5.5 Refs
A (Rhodopsin) Prostanoid TA2R TP Human Pge2 None 2 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O XEYBRNLFEZDVAW-ARSRFYASSA-N 4.5 4.5 Refs
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl14 Peptide - -
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Mouse Urocortin 2 2 Peptide - - Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Thromboxane A2 4 Small molecule CCCCC[C@@H](/C=C/[C@H]1O[C@H]2C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O2)O DSNBHJFQCNUKMA-SCKDECHMSA-N
A (Rhodopsin) Opioid OPRX NOP Mouse Nociceptin/Orphanin Fq Principal 1 Peptide - PULGYDLMFSFVBL-SMFNREODSA-N 8.4 9.1 9.8 9.7 9.4 9.4 Refs
A (Rhodopsin) Prokineticin PKR1 PKR1 Human Prokineticin-2 1 Peptide - - Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl2 8 Peptide - -
A (Rhodopsin) Neurotensin NTR2 NTS2 Human Neuromedin N 2 Peptide - -
A (Rhodopsin) Dopamine DRD4 D4 Rat Dopamine Principal 1 Small molecule NCCc1ccc(c(c1)O)O VYFYYTLLBUKUHU-UHFFFAOYSA-N 7.6 7.6 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Rat Pancreatic Polypeptide 1 Peptide - - 10.3 10.6 10.8 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl14 7 Peptide - - 7.2 7.2 Refs
A (Rhodopsin) Melanocortin MSHR MC1 Human Β-Msh 2 Peptide - -
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Rat Urocortin 3 2 Peptide - - Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Mouse Urocortin 1 2 Peptide - - Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Human Urocortin 3 2 Peptide - - Refs
A (Rhodopsin) Complement peptide C3AR C3a Human C3a 2 Peptide - -
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Cck-33 2 Peptide - QFLBZJPOIZFFJQ-UHFFFAOYSA-N Refs
B1 (Secretin) Glucagon receptor family SCTR secretin Human Secretin 2 Peptide - -
A (Rhodopsin) Galanin GALR3 GAL3 Human Galanin-Like Peptide 2 Peptide - - Refs
A (Rhodopsin) Free fatty acid FFAR2 FFA2 Human Propanoic Acid None 1 Small molecule CCC(=O)O XBDQKXXYIPTUBI-UHFFFAOYSA-N 3.0 4.0 4.9 Refs
A (Rhodopsin) Opioid OPRK κ Human Α-Neoendorphin 3 Peptide - KZTDMJBCZSGHOG-XJIZABAQSA-N 8.3 9.3 10.2 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR1 LPA1 Mouse Lpa Principal 1 Small molecule CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O WRGQSWVCFNIUNZ-KTKRTIGZSA-N 7.9 8.1 8.3 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR4 S1P4 Human Sphingosine 1-Phosphate None 1 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O DUYSYHSSBDVJSM-KRWOKUGFSA-N 7.2 7.7 8.1 Refs
A (Rhodopsin) Class A orphan GPR35 GPR35 Mouse Kynurenic Acid None 2 Small molecule OC(=O)c1cc(=O)c2c([nH]1)cccc2 HCZHHEIFKROPDY-UHFFFAOYSA-N 3.9 5.0 5.0 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Gastrin-17 5 Peptide - -
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl17 Peptide - -
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl4 7 Peptide - -
A (Rhodopsin) Adenosine AA2BR A2B Rat Adenosine Principal 1 Small molecule OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N OIRDTQYFTABQOQ-KQYNXXCUSA-N 4.8 4.8 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Rat Pacap-27 2 Peptide - RZGBUJXSKLDAFE-UHFFFAOYSA-N 7.4 8.9 10.6 6.9 8.0 8.5 Refs
C (Glutamate) Calcium-sensing CASR CaS Human Mg2+ None 3 Small molecule [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N
A (Rhodopsin) Apelin APJ apelin Human Apelin-13 2 Peptide - XXCCRHIAIBQDPX-PEWBXTNBSA-N Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Annexin I 9 Peptide - -
A (Rhodopsin) Prokineticin PKR2 PKR2 Human Prokineticin-1 4 Peptide - -
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl26 5 Peptide - - Refs
A (Rhodopsin) Melanocortin MC3R MC3 Human Γ-Msh 3 Peptide - - Refs
A (Rhodopsin) Dopamine DRD3 D3 Human Dopamine Principal 1 Small molecule NCCc1ccc(c(c1)O)O VYFYYTLLBUKUHU-UHFFFAOYSA-N 6.4 6.9 7.3 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl2 5 Peptide - -
A (Rhodopsin) P2Y P2Y14 P2Y14 Mouse Udp-Galactose None 2 Small molecule OC[C@H]1O[C@H](OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2ccc(=O)[nH]c2=O)O)O)[C@@H]([C@H]([C@H]1O)O)O HSCJRCZFDFQWRP-ABVWGUQPSA-N 7.6 7.6 Refs
A (Rhodopsin) GPR18, GPR55 and GPR119 GP119 GPR119 Human N-Oleoylethanolamide None 1 Small molecule CCCCCCCC/C=C\CCCCCCCC(=O)NCCO BOWVQLFMWHZBEF-KTKRTIGZSA-N 5.4 5.9 6.3 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Pgf2Α None 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O PXGPLTODNUVGFL-YNNPMVKQSA-N 6.1 6.1 9.1 9.3 9.5 Refs
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Rat Pancreatic Polypeptide 5 Peptide - - 6.5 6.5 Refs
A (Rhodopsin) Hydroxycarboxylic acid HCAR3 HCA3 Human 3-Hydroxyoctanoic Acid Principal 1 Small molecule CCCCC[C@@H](CC(=O)O)O NDPLAKGOSZHTPH-ZETCQYMHSA-N 5.1 5.1 Refs
A (Rhodopsin) Galanin GALR1 GAL1 Rat Galanin-Like Peptide 2 Peptide - - Refs
C (Glutamate) Class C Orphan GPC6A GPRC6 Human L-Ornithine None 2 Small molecule N[C@H](C(=O)O)CCCN AHLPHDHHMVZTML-BYPYZUCNSA-N 4.0 4.0 Refs
A (Rhodopsin) Bile acid GPBAR GPBA Human Deoxycholic Acid None 2 Small molecule O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C KXGVEGMKQFWNSR-LLQZFEROSA-N 6.2 6.2 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1D 5-HT1D Human 5-Ht-Moduline None 2 Peptide - IMIVWAUMTAIVPJ-XUXIUFHCSA-N Refs
A (Rhodopsin) Opioid OPRM μ Human [Leu]Enkephalin 5 Peptide - URLZCHNOLZSCCA-UHFFFAOYSA-N 8.1 8.1 Refs
A (Rhodopsin) Adren ADA1D α1D Rat (-)-Noradrenaline None 2 Small molecule NC[C@@H](c1ccc(c(c1)O)O)O SFLSHLFXELFNJZ-QMMMGPOBSA-N 6.6 7.2 7.8 5.5 6.5 7.4 Refs
A (Rhodopsin) Relaxin family peptide Q5Y986 RXFP3 Rat Relaxin-3 3 Peptide - - Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl1 3 Peptide - -
B1 (Secretin) Glucagon receptor family GLP1R GLP-1 Human Glucagon-Like Peptide 1-(7-37) 3 Peptide - GCYXWQUSHADNBF-AAEALURTSA-N Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl14 6 Peptide - - 7.4 7.4 Refs
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Cathepsin G 2 Peptide - -
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl7 4 Peptide - - Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR5 S1P5 Human Sphingosylphosphorylcholine 2 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(OCC[N+](C)(C)C)[O-])N)O JLVSPVFPBBFMBE-HXSWCURESA-N
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl13 2 Peptide - - Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Secretin 4 Peptide - KKNIUBFRGPFELP-UHFFFAOYSA-N
C (Glutamate) Metabotropic glutamate GRM8 mGlu8 Human L-Glutamic Acid None 1 Small molecule OC(=O)CC[C@@H](C(=O)O)N WHUUTDBJXJRKMK-VKHMYHEASA-N 4.9 5.3 5.6 Refs
A (Rhodopsin) Neuropeptide Y NPY1R Y1 Human Pancreatic Polypeptide 4 Peptide - -
A (Rhodopsin) P2Y P2RY4 P2Y4 Rat Utp None 1 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O PGAVKCOVUIYSFO-XVFCMESISA-N 6.3 6.3 Refs
A (Rhodopsin) Galanin GALR2 GAL2 Human Galanin-Like Peptide 4 Peptide - - Refs
A (Rhodopsin) Relaxin family peptide RL3R1 RXFP3 Human Relaxin 2 Peptide - - 7.1 7.8 8.4 Refs
A (Rhodopsin) Tachykinin NK3R NK3 Mouse Substance P 3 Peptide - ADNPLDHMAVUMIW-CUZNLEPHSA-N 5.0 5.5 6.0 Refs
A (Rhodopsin) Chemokine ACKR4 ACKR4 Human Ccl25 3 Peptide - - 7.9 8.1 8.3 7.6 7.6 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl6 3 Peptide - - Refs
A (Rhodopsin) Neurotensin NTR1 NTS1 Rat Neuromedin N 2 Peptide - - 8.7 8.7 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl5 8 Peptide - -
A (Rhodopsin) Melanocortin ACTHR MC2 Human Acth Principal 1 Peptide - - Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Resolvin D1 None 2 Small molecule CC/C=C\C[C@@H](/C=C/C=C\C=C\C=C\[C@@H]([C@H](C/C=C\CCC(=O)O)O)O)O OIWTWACQMDFHJG-LDOXQWQISA-N 11.9 11.9 Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Agouti-Related Protein 2 Peptide - - Refs
A (Rhodopsin) Adren ADA1B α1B Human (-)-Adrenaline None 2 Small molecule CNC[C@@H](c1ccc(c(c1)O)O)O UCTWMZQNUQWSLP-VIFPVBQESA-N 5.4 7.4 9.4 3.9 5.2 6.5 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Rat Pge1 None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O GMVPRGQOIOIIMI-DWKJAMRDSA-N 9.4 9.4 9.0 9.0 Refs
A (Rhodopsin) Neuropeptide Y NPY1R Y1 Human Peptide Yy 2 Peptide - IXMRLEGHWROJAA-HDTKZREISA-N 10.2 10.2 Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Ll-37 7 Peptide - POIUWJQBRNEFGX-XAMSXPGMSA-N 6.0 6.0 Refs
A (Rhodopsin) Neuropeptide Y NPY1R Y1 Rat Neuropeptide Y 1 Peptide - XKWCTHKJQNUFOQ-HRPSIEBRSA-N 10.5 10.5 Refs
A (Rhodopsin) P2Y P2Y11 P2Y11 Human Adp None 3 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N XTWYTFMLZFPYCI-KQYNXXCUSA-N Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Human Lys-[Hyp3]-Bradykinin 6 Peptide - -
A (Rhodopsin) Histamine HRH2 H2 Rat Histamine Principal 1 Small molecule NCCc1cnc[nH]1 NTYJJOPFIAHURM-UHFFFAOYSA-N 3.8 3.8 Refs
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Human Neuropeptide Y 1 Peptide - XKWCTHKJQNUFOQ-HRPSIEBRSA-N 9.3 9.3 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl16 8 Peptide - -
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Annexin I 2 Peptide - -
A (Rhodopsin) Chemokine CCR9 CCR9 Human Ccl25 Principal 1 Peptide - -
A (Rhodopsin) Neurotensin NTR1 NTS1 Human Large Neuromedin N 3 Peptide - -
A (Rhodopsin) P2Y P2Y12 P2Y12 Human Adp None 1 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N XTWYTFMLZFPYCI-KQYNXXCUSA-N 5.9 5.9 Refs
A (Rhodopsin) Bile acid GPBAR GPBA Human Chenodeoxycholic Acid None 3 Small molecule O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C RUDATBOHQWOJDD-BSWAIDMHSA-N 5.4 5.4 Refs
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Tip39 2 Peptide - - Refs
A (Rhodopsin) Neuromedin U NMUR1 NMU1 Human Neuromedin U-23 3 Peptide - -
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide B-29 5 Peptide - -
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Human Pancreatic Polypeptide 4 Peptide - - 8.0 8.0 Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Human Atp None 6 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N ZKHQWZAMYRWXGA-KQYNXXCUSA-N 7.4 7.4 Refs
C (Glutamate) Calcium-sensing CASR CaS Rat Mg2+ None 3 Small molecule [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N Refs
B2 (Adhesion) ADGRL AGRL1 ADGRL1 Rat Lasso D Principal 1 Peptide - - Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR5 LPA5 Human Farnesyl Monophosphate None 1 Small molecule C/C(=C/CC/C(=C\COP(=O)(O)O)/C)/CCC=C(C)C ALEWCKXBHSDCCT-FBXUGWQNSA-N 7.3 7.3 Refs
A (Rhodopsin) Somatostatin SSR1 SST1 Human Cortistatin-14 4 Peptide - -
A (Rhodopsin) GPR18, GPR55 and GPR119 GPR55 GPR55 Human 2-Arachidonoylglycerol None 1 Small molecule CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)OC(CO)CO RCRCTBLIHCHWDZ-DOFZRALJSA-N 8.5 8.5 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Human Phi 4 Peptide - -
A (Rhodopsin) Class A orphan GPR17 GPR17 Human Udp-Glucose None 4 Small molecule OC[C@H]1O[C@H](OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2ccc(=O)[nH]c2=O)O)O)[C@@H]([C@H]([C@@H]1O)O)O HSCJRCZFDFQWRP-JZMIEXBBSA-N 5.9 7.7 9.5 Refs
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Pthrp-(1-34) (Human) None 4 Peptide - ZOWOHMFPXMYFKJ-WBTWNKCNSA-N Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Human Cortistatin-14 4 Peptide - - 8.7 9.1 9.4 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide B-23 4 Peptide - - Refs
A (Rhodopsin) Leukotriene LT4R1 BLT1 Human 20-Hydroxy-Ltb4 None 2 Small molecule OCCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O PTJFJXLGRSTECQ-PSPARDEHSA-N 8.1 8.1 Refs
A (Rhodopsin) Chemokine CCR8 CCR8 Mouse Ccl8 2 Peptide - -
A (Rhodopsin) Prostanoid PD2R2 DP2 Rat Pgd2 None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O BHMBVRSPMRCCGG-OUTUXVNYSA-N 7.4 7.5 7.5 Refs
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Cathepsin G 2 Peptide - -
A (Rhodopsin) Class A orphan GPR75 GPR75 Human Ccl5 Principal 1 Peptide - - 9.6 9.6 Refs
A (Rhodopsin) Prostanoid PF2R FP Mouse Pgf2Α None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O PXGPLTODNUVGFL-YNNPMVKQSA-N 7.9 8.2 8.5 Refs
A (Rhodopsin) Class A orphan MRGRD MRGPRD Human Β-Alanine Principal 1 Small molecule NCCC(=O)O UCMIRNVEIXFBKS-UHFFFAOYSA-N 4.8 4.8 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR1 CRF1 Human Urocortin 1 4 Peptide - -
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl2 3 Peptide - -
C (Glutamate) GABAB GABR1 GABAB1 Rat Gaba Principal 1 Small molecule NCCCC(=O)O BTCSSZJGUNDROE-UHFFFAOYSA-N Refs
A (Rhodopsin) Neurotensin NTR1 NTS1 Human Large Neuromedin N 3 Peptide - -
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide W-30 2 Peptide - - Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl7 8 Peptide - -
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Gastrin-71 5 Peptide - -
A (Rhodopsin) Class A orphan LGR5 LGR5 Human R-Spondin-1 2 Peptide - - 11.1 11.1 Refs
A (Rhodopsin) Chemokine CXCR1 CXCR1 Human Cxcl6 2 Peptide - - 7.0 7.0 Refs
A (Rhodopsin) Chemerin CML1 chemerin Human Chemerin C-Terminal Peptide None 2 Peptide - QLVGSBXIQFERFK-NBBYSTNSSA-N
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Cck-33 5 Peptide - -
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Pgd2 None 2 Small molecule CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O BHMBVRSPMRCCGG-OUTUXVNYSA-N 8.8 8.8 8.7 8.9 9.0 Refs
A (Rhodopsin) Thyrotropin-releasing hormone TRHR TRH1 Rat Trh Principal 1 Peptide - XNSAINXGIQZQOO-SRVKXCTJSA-N 7.4 7.4 Refs
A (Rhodopsin) Leukotriene OXER1 OXE Human 5-Oxo-C20:3 None 2 Small molecule CCCCCCCC/C=C\C/C=C\C=C/C(=O)CCCC(=O)O ULMVEQWNDGUUBR-IEQFDQMRSA-N 8.0 8.0 Refs
A (Rhodopsin) Adren ADA1B α1B Human (-)-Noradrenaline None 1 Small molecule NC[C@@H](c1ccc(c(c1)O)O)O SFLSHLFXELFNJZ-QMMMGPOBSA-N 5.9 7.6 9.2 3.8 5.0 6.2 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Gastrin-14 5 Peptide - SSBRJDBGIVUNDK-QOGDCIHTSA-N
A (Rhodopsin) Trace amine TAAR1 TA1 Human Dopamine 4 Small molecule NCCc1ccc(c(c1)O)O VYFYYTLLBUKUHU-UHFFFAOYSA-N
A (Rhodopsin) Prostanoid PE2R2 EP2 Mouse Pge1 None 1 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O GMVPRGQOIOIIMI-DWKJAMRDSA-N 8.0 8.0 Refs
A (Rhodopsin) Tachykinin NK3R NK3 Mouse Neurokinin A 2 Peptide - HEAUFJZALFKPBA-JPQUDPSNSA-N 7.4 7.4 5.5 6.1 6.1 Refs
A (Rhodopsin) Hydroxycarboxylic acid HCAR2 HCA2 Mouse Β-D-Hydroxybutyric Acid None 1 Small molecule C[C@H](CC(=O)O)O WHBMMWSBFZVSSR-GSVOUGTGSA-N 3.5 3.5 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Cck-33 5 Peptide - -
A (Rhodopsin) Neurotensin NTR1 NTS1 Human Neuromedin N 2 Peptide - - 8.7 8.7 Refs
A (Rhodopsin) Opioid OPRM μ Human Endomorphin-1 4 Peptide - ZEXLJFNSKAHNFH-SYKYGTKKSA-N 8.3 8.3 Refs
A (Rhodopsin) Tachykinin NK3R NK3 Human Neurokinin A 2 Peptide - HEAUFJZALFKPBA-JPQUDPSNSA-N 7.4 7.4 5.5 6.1 6.1 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl7 6 Peptide - - 7.5 7.5 Refs
A (Rhodopsin) Opioid OPRK κ Human Β-Neoendorphin 4 Peptide - RTXIYIQLESPXIV-VLOLPVCOSA-N 9.1 9.1 Refs
A (Rhodopsin) Chemokine ACKR4 ACKR4 Human Ccl21 2 Peptide - - 7.9 8.2 8.5 6.9 6.9 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR6 LPA6 Human Lpa Principal 1 Small molecule CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O WRGQSWVCFNIUNZ-KTKRTIGZSA-N 6.0 6.0 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide B-29 5 Peptide - -
A (Rhodopsin) Melanocortin MSHR MC1 Human Acth 2 Peptide - -
A (Rhodopsin) Lysophospholipid (S1P) S1PR5 S1P5 Human Dihydrosphingosine 1-Phosphate 2 Small molecule CCCCCCCCCCCCCCC[C@H]([C@H](COP(=O)(O)O)N)O YHEDRJPUIRMZMP-ZWKOTPCHSA-N
A (Rhodopsin) Bradykinin BKRB2 B2 Human Kallidin 1 Peptide - FYSKZKQBTVLYEQ-FSLKYBNLSA-N Refs
A (Rhodopsin) Opioid OPRD δ Human Dynorphin A 5 Peptide - JMNJYGMAUMANNW-FIXZTSJVSA-N 7.4 7.4 Refs
A (Rhodopsin) Complement peptide C3AR C3a Human C3a 1 Peptide - - 7.3 8.5 9.6 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Ghrh 4 Peptide - -
A (Rhodopsin) Dopamine DRD5 D5 Human Noradrenaline None 3 Small molecule NCC(c1ccc(c(c1)O)O)O SFLSHLFXELFNJZ-UHFFFAOYSA-N 4.9 4.9 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR2 LPA2 Human Farnesyl Diphosphate None 2 Small molecule C/C(=C/COP(=O)(OP(=O)(O)O)O)/CC/C=C(\CCC=C(C)C)/C VWFJDQUYCIWHTN-FBXUGWQNSA-N Refs
B2 (Adhesion) ADGRL AGRL3 ADGRL3 Rat Flrt3 Principal 1 Peptide - - Refs
A (Rhodopsin) Chemokine CCR10 CCR10 Human Ccl27 Peptide - - Refs
A (Rhodopsin) Melanocortin MC4R MC4 Human Β-Msh 3 Peptide - -
A (Rhodopsin) Melanocortin MC4R MC4 Human Acth 2 Peptide - IDLFZVILOHSSID-OVLDLUHVSA-N 6.2 6.2 Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Cxcl10 2 Peptide - - 7.8 8.8 9.8 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide W-30 5 Peptide - -
A (Rhodopsin) Neurotensin NTR2 NTS2 Mouse Neuromedin N 2 Peptide - - Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Human Pgf2Α None 4 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O PXGPLTODNUVGFL-YNNPMVKQSA-N 6.4 6.4 Refs
A (Rhodopsin) Class A orphan GPR35 GPR35 Human 2-Oleoyl-Lpa None 1 Small molecule CCCCCCCC/C=C\CCCCCCCC(=O)OC(COP(=O)(O)O)CO ZOOLJLSXNRZLDH-KTKRTIGZSA-N 7.3 7.4 7.5 Refs
A (Rhodopsin) Prostanoid PF2R FP Human Pge2 None 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O XEYBRNLFEZDVAW-ARSRFYASSA-N 6.4 6.7 6.9 Refs
C (Glutamate) Calcium-sensing CASR CaS Human Spermine None 1 Small molecule NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N Refs
A (Rhodopsin) Cannabinoid CNR1 CB1 Human Anandamide None 2 Small molecule CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCO LGEQQWMQCRIYKG-DOFZRALJSA-N 6.3 6.7 7.0 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Ghrh 4 Peptide - -
A (Rhodopsin) Chemerin CML1 chemerin Human Epa 2 Small molecule CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O JAZBEHYOTPTENJ-JLNKQSITSA-N
A (Rhodopsin) Peptide P518 QRFPR QRFP Human Qrfp43 5 Peptide - -
A (Rhodopsin) Chemokine CCR7 CCR7 Mouse Ccl21b 2 Peptide - - Refs
A (Rhodopsin) Apelin APJ apelin Human Apelin Receptor Early Endogenous Ligand 2 Peptide - -
A (Rhodopsin) Glycoprotein hormone TSHR TSH Human Tsh Principal 1 Peptide - -
A (Rhodopsin) Angiotensin AGTR1 AT1 Human Angiotensin Iv 2 Peptide - QSBGWDDCOJYQGY-KOQODJNWSA-N 5.9 5.9 Refs
A (Rhodopsin) Free fatty acid FFAR1 FFA1 Human Α-Linolenic Acid None 2 Small molecule CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O DTOSIQBPPRVQHS-PDBXOOCHSA-N 4.6 5.2 5.7 Refs
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Ccl11 Peptide - -
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl11 5 Peptide - -
C (Glutamate) Metabotropic glutamate GRM5 mGlu5 Human L-Glutamic Acid Principal 1 Small molecule OC(=O)CC[C@@H](C(=O)O)N WHUUTDBJXJRKMK-VKHMYHEASA-N 5.0 5.3 5.5 Refs
A (Rhodopsin) Opioid OPRK κ Human [Leu]Enkephalin 8 Peptide - URLZCHNOLZSCCA-UHFFFAOYSA-N 6.0 6.0 Refs
A (Rhodopsin) Class A orphan LGR4 LGR4 Human R-Spondin-4 3 Peptide - - 10.1 10.1 Refs
A (Rhodopsin) Adren ADRB1 β1 Human Noradrenaline None 3 Small molecule NCC(c1ccc(c(c1)O)O)O SFLSHLFXELFNJZ-UHFFFAOYSA-N 6.0 6.0 Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Mouse Ltc4 None 2 Small molecule CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N GWNVDXQDILPJIG-NXOLIXFESA-N 7.8 9.1 9.1 Refs
A (Rhodopsin) Complement peptide C5AR2 C5a2 Human C5a 1 Peptide - - 8.9 8.9 Refs
A (Rhodopsin) Chemokine ACKR3 ACKR3 Rat Adrenomedullin 2 Peptide - - 7.0 7.0 Refs
A (Rhodopsin) Class A orphan GPR32 GPR32 Human Resolvin D1 None 1 Small molecule CC/C=C\C[C@@H](/C=C/C=C\C=C\C=C\[C@@H]([C@H](C/C=C\CCC(=O)O)O)O)O OIWTWACQMDFHJG-LDOXQWQISA-N 11.1 11.1 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR1 S1P1 Human Sphingosylphosphorylcholine 2 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(OCC[N+](C)(C)C)[O-])N)O JLVSPVFPBBFMBE-HXSWCURESA-N
A (Rhodopsin) Neuropeptide Y NPY1R Y1 Rat Peptide Yy 2 Peptide - IXMRLEGHWROJAA-HDTKZREISA-N 10.2 10.2 Refs
A (Rhodopsin) Proteinase-activated PAR4 PAR4 Human Cathepsin G Peptide - -
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Neuropeptide Af 3 Peptide - YPBGORNZMUQFSF-KWFINLGMSA-N
A (Rhodopsin) Melanocortin MSHR MC1 Human Acth 1 Peptide - IDLFZVILOHSSID-OVLDLUHVSA-N 8.6 8.6 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl16 7 Peptide - -
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Des-Br-Neuropeptide B-23 4 Peptide - - Refs
A (Rhodopsin) Angiotensin AGTR2 AT2 Human Angiotensin-(1-7) 3 Peptide - PVHLMTREZMEJCG-GDTLVBQBSA-N Refs
A (Rhodopsin) Dopamine DRD5 D5 Human (-)-Noradrenaline None 3 Small molecule NC[C@@H](c1ccc(c(c1)O)O)O SFLSHLFXELFNJZ-QMMMGPOBSA-N
A (Rhodopsin) Class A orphan LGR6 LGR6 Human R-Spondin-3 Peptide - - Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR5 LPA5 Human Farnesyl Diphosphate None 2 Small molecule C/C(=C/COP(=O)(OP(=O)(O)O)O)/CC/C=C(\CCC=C(C)C)/C VWFJDQUYCIWHTN-FBXUGWQNSA-N 5.8 6.2 6.5 Refs
A (Rhodopsin) Prostanoid PF2R FP Human Pgd2 None 2 Small molecule CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O BHMBVRSPMRCCGG-OUTUXVNYSA-N 7.3 7.3 Refs
A (Rhodopsin) Endothelin EDNRB ETB Human Endothelin-2 2 Peptide - -
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Phi 4 Peptide - -
A (Rhodopsin) Melanocortin MC4R MC4 Human Acth 3 Peptide - -
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Cck-33 2 Peptide - -
A (Rhodopsin) P2Y P2RY6 P2Y6 Human Utp None 2 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O PGAVKCOVUIYSFO-XVFCMESISA-N 5.2 5.2 Refs
A (Rhodopsin) Melanocortin MSHR MC1 Human Γ-Msh 2 Peptide - -
A (Rhodopsin) Kisspeptin KISSR kisspeptin Human Kisspeptin-52 5 Peptide - -
A (Rhodopsin) Class A orphan P2Y10 P2RY10 Human Lpa None 2 Small molecule CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O WRGQSWVCFNIUNZ-KTKRTIGZSA-N 6.9 6.9 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR3 LPA3 Mouse Lpa None 1 Small molecule CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O WRGQSWVCFNIUNZ-KTKRTIGZSA-N 6.6 6.6 Refs
A (Rhodopsin) Class A orphan GPR3 GPR3 Human Sphingosine 1-Phosphate Principal 1 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O DUYSYHSSBDVJSM-KRWOKUGFSA-N 7.1 7.4 7.7 Refs
A (Rhodopsin) Proteinase-activated PAR1 PAR1 Human Thrombin Principal 1 Peptide - -
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Human Urocortin 1 2 Peptide - - Refs
A (Rhodopsin) Class A orphan P2Y10 P2RY10 Human Sphingosine 1-Phosphate None 1 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O DUYSYHSSBDVJSM-KRWOKUGFSA-N 7.3 7.3 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR1 S1P1 Human Dihydrosphingosine 1-Phosphate 2 Small molecule CCCCCCCCCCCCCCC[C@H]([C@H](COP(=O)(O)O)N)O YHEDRJPUIRMZMP-ZWKOTPCHSA-N
A (Rhodopsin) Melanocortin MC4R MC4 Human Β-Msh 3 Peptide - -
B1 (Secretin) Glucagon receptor family GLP2R GLP-2 Human Glucagon-Like Peptide 2 4 Peptide - VSJTUHNYLFMYOE-HUADCCRNSA-N
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Neuropeptide Af 3 Peptide - -
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Cck-33 2 Peptide - -
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl8 8 Peptide - -
A (Rhodopsin) Bradykinin BKRB2 B2 Mouse [Des-Arg9]Bradykinin 2 Peptide - VCEHWDBVPZFHAG-UHFFFAOYSA-N Refs
A (Rhodopsin) Class A orphan GP183 GPR183 Human 7Β, 25-Dihydroxycholesterol None 3 Small molecule O[C@H]1CC[C@]2(C(=C[C@@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C BQMSKLCEWBSPPY-CGSQRZAOSA-N 8.7 8.7 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT2A 5-HT2A Rat Tryptamine None 2 Small molecule NCCc1c[nH]c2c1cccc2 APJYDQYYACXCRM-UHFFFAOYSA-N 5.5 6.6 7.6 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl3 3 Peptide - -
A (Rhodopsin) Opioid OPRD δ Human Β-Endorphin 3 Peptide - JMHFFDIMOUKDCZ-NTXHZHDSSA-N 8.3 8.3 Refs
A (Rhodopsin) Formylpeptide FPR3 FPR3 Human Humanin 1 Peptide - DPEUWKZJZIPZKE-OFANTOPUSA-N 8.9 8.9 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Rat Pyy-(3-36) 6 Peptide - - 6.2 6.2 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Human Urocortin 2 2 Peptide - PIXFIEBACLDPNF-SKCWXFKWSA-N Refs
A (Rhodopsin) GPR18, GPR55 and GPR119 GPR18 GPR18 Human N-Arachidonoylglycine Principal 1 Small molecule CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCC(=O)O YLEARPUNMCCKMP-DOFZRALJSA-N 7.3 7.5 7.7 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Cck-8 1 Peptide - IZTQOLKUZKXIRV-YRVFCXMDSA-N Refs
A (Rhodopsin) Glycoprotein hormone FSHR FSH Human Fsh Principal 1 Peptide - -
A (Rhodopsin) Melanocortin MC3R MC3 Human Acth 2 Peptide - IDLFZVILOHSSID-OVLDLUHVSA-N 7.1 7.1 Refs
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Human Pyy-(3-36) 3 Peptide - - 8.4 8.4 Refs
A (Rhodopsin) Prostanoid TA2R TP Human Pgi2 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O KAQKFAOMNZTLHT-OZUDYXHBSA-N
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Secretin 4 Peptide - -
B1 (Secretin) Parathyroid hormone PTH1R PTH1 Human Pthrp-(1-36) 2 Peptide - NNRMZXDHMCWWRV-RHBZDGMUSA-N Refs
C (Glutamate) Class C Orphan GPC6A GPRC6 Human L-Citrulline None 4 Small molecule NC(=O)NCCC[C@@H](C(=O)O)N RHGKLRLOHDJJDR-BYPYZUCNSA-N 3.6 3.6 Refs
A (Rhodopsin) Neurotensin NTR2 NTS2 Human Xenin 2 Peptide - IDHVLSACPFUBDY-QCDLPZBNSA-N Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide W-30 5 Peptide - -
A (Rhodopsin) Opioid OPRD δ Human Dynorphin B 4 Peptide - AGTSSZRZBSNTGQ-ITZCFHCWSA-N 7.8 7.8 Refs
B1 (Secretin) Calcitonin CALCR CT Human Α-Cgrp 7 Peptide - -
A (Rhodopsin) Galanin GALR3 GAL3 Human Spexin-1 1 Peptide - - 6.2 6.2 Refs
A (Rhodopsin) Orexin OX1R OX1 Human Orexin-B 3 Peptide - WGMOJBHHMACBCG-GWQFQBPDSA-N
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl8 3 Peptide - - 9.3 9.3 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR2 LPA2 Human Farnesyl Monophosphate None 2 Small molecule C/C(=C/CC/C(=C\COP(=O)(O)O)/C)/CCC=C(C)C ALEWCKXBHSDCCT-FBXUGWQNSA-N Refs
A (Rhodopsin) Chemokine XCR1 XCR1 Human Xcl1 2 Peptide - -
A (Rhodopsin) Leukotriene LT4R2 BLT2 Human 20-Hydroxy-Ltb4 4 Small molecule OCCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O PTJFJXLGRSTECQ-PSPARDEHSA-N
A (Rhodopsin) Neuropeptide S NPSR1 NPS Human Neuropeptide S Principal 1 Peptide - XBNIXBCJICZFRR-GYDKITGDSA-N
A (Rhodopsin) Leukotriene LT4R2 BLT2 Human 12r-Hete 4 Small molecule CCCCC/C=C\C[C@H](/C=C/C=C\C/C=C\CCCC(=O)O)O ZNHVWPKMFKADKW-ZYBDYUKJSA-N
B1 (Secretin) Glucagon receptor family GLP2R GLP-2 Human Glucagon-Like Peptide 2 4 Peptide - TWSALRJGPBVBQU-PKQQPRCHSA-N Refs
A (Rhodopsin) Chemokine XCR1 XCR1 Human Xcl1 2 Peptide - -
B1 (Secretin) VIP and PACAP PACR PAC1 Human Phv 4 Peptide - -
A (Rhodopsin) Prokineticin PKR2 PKR2 Human Prokineticin-2 4 Peptide - -
A (Rhodopsin) Lysophospholipid (LPA) LPAR4 LPA4 Human Lpa None 1 Small molecule CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O WRGQSWVCFNIUNZ-KTKRTIGZSA-N Refs
Other GPCRs Other GPCR orphan GP143 GPR143 Human Levodopa Principal 1 Small molecule OC(=O)[C@H](Cc1ccc(c(c1)O)O)N WTDRDQBEARUVNC-LURJTMIESA-N Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Rat Pgd2 None 4 Small molecule CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O BHMBVRSPMRCCGG-OUTUXVNYSA-N 5.2 5.2 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR2 S1P2 Human Sphingosylphosphorylcholine 2 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(OCC[N+](C)(C)C)[O-])N)O JLVSPVFPBBFMBE-HXSWCURESA-N
B1 (Secretin) Glucagon receptor family GIPR GIP Human Gastric Inhibitory Polypeptide Principal 1 Peptide - -
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide B-23 5 Peptide - -
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl8 7 Peptide - -
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl15 7 Peptide - - Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Human Pgd2 None 4 Small molecule CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O BHMBVRSPMRCCGG-OUTUXVNYSA-N 5.3 5.3 Refs
A (Rhodopsin) Endothelin EDNRB ETB Human Endothelin-2 2 Peptide - MLFJHYIHIKEBTQ-IYRKOGFYSA-N
A (Rhodopsin) Opioid OPRM μ Human Endomorphin-2 6 Peptide - XIJHWXXXIMEHKW-LJWNLINESA-N
A (Rhodopsin) Prokineticin PKR2 PKR2 Human Prokineticin-2Β 3 Peptide - - Refs
A (Rhodopsin) Glycoprotein hormone FSHR FSH Human Fsh Principal 1 Peptide - -
C (Glutamate) Class C Orphan GPC6A GPRC6 Human L-Glutamine None 5 Small molecule NC(=O)CC[C@@H](C(=O)O)N ZDXPYRJPNDTMRX-VKHMYHEASA-N 3.2 3.2 Refs
A (Rhodopsin) Relaxin family peptide RXFP2 RXFP2 Human Relaxin-1 2 Peptide - - 8.8 8.8 Refs
A (Rhodopsin) Opioid OPRK κ Human [Met]Enkephalin 8 Peptide - YFGBQHOOROIVKG-FKBYEOEOSA-N 6.0 6.0 Refs
A (Rhodopsin) Angiotensin AGTR1 AT1 Human Angiotensin Ii 3 Peptide - CZGUSIXMZVURDU-JZXHSEFVSA-N
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl7 8 Peptide - -
A (Rhodopsin) Opioid OPRD δ Human Α-Neoendorphin 7 Peptide - KZTDMJBCZSGHOG-XJIZABAQSA-N Refs
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Gastrin-17 2 Peptide - -
A (Rhodopsin) Chemokine CX3C1 CX3CR1 Human Cx3Cl1 Principal 1 Peptide - -
A (Rhodopsin) Opioid OPRM μ Human Β-Endorphin 6 Peptide - HQALISCIMNBRAE-XJTHNYJFSA-N
A (Rhodopsin) Chemokine CCR4 CCR4 Human Ccl22 1 Peptide - - Refs
A (Rhodopsin) Proteinase-activated PAR4 PAR4 Human Cathepsin G Peptide - -
A (Rhodopsin) Chemokine CCR10 CCR10 Human Ccl28 Peptide - -
A (Rhodopsin) Prostanoid PI2R IP Human Pge2 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O XEYBRNLFEZDVAW-ARSRFYASSA-N
A (Rhodopsin) Opioid OPRD δ Human Β-Endorphin 7 Peptide - KSZMZNRVPCEDEO-KFHPFRHLSA-N
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Secretin 4 Peptide - -
A (Rhodopsin) P2Y P2Y14 P2Y14 Rat Udp-Glucose None 1 Small molecule OC[C@H]1O[C@H](OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2ccc(=O)[nH]c2=O)O)O)[C@@H]([C@H]([C@@H]1O)O)O HSCJRCZFDFQWRP-JZMIEXBBSA-N 7.7 7.7 Refs
A (Rhodopsin) Class A orphan GP183 GPR183 Human 7Α,25-Dihydroxycholesterol None 1 Small molecule O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)O)C1)C BQMSKLCEWBSPPY-IKVTXIKFSA-N 8.1 9.0 9.9 Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Cxcl9 3 Peptide - - 7.3 7.8 8.3 Refs
A (Rhodopsin) Neuropeptide S NPSR1 NPS Human Neuropeptide S Principal 1 Peptide - -
A (Rhodopsin) Peptide P518 QRFPR QRFP Mouse Qrfp26 1 Peptide - - 8.2 8.2 Refs
A (Rhodopsin) Class A orphan LGR5 LGR5 Human R-Spondin-3 3 Peptide - - 11.0 11.0 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Human Thromboxane A2 6 Small molecule CCCCC[C@@H](/C=C/[C@H]1O[C@H]2C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O2)O DSNBHJFQCNUKMA-SCKDECHMSA-N
A (Rhodopsin) Angiotensin AGTR1 AT1 Human Angiotensin Iii 3 Peptide - UCRMCWFIVZYPFA-LGXQCQDRSA-N
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide W-23 5 Peptide - -
A (Rhodopsin) Class A orphan LGR6 LGR6 Human R-Spondin-2 Peptide - - Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Human Pyy-(3-36) 6 Peptide - - 6.2 6.2 Refs
A (Rhodopsin) Thyrotropin-releasing hormone TRFR TRH1 Human Trh Principal 1 Peptide - XNSAINXGIQZQOO-SRVKXCTJSA-N 7.4 7.4 Refs
A (Rhodopsin) Proteinase-activated PAR3 PAR3 Human Thrombin Principal 1 Peptide - -
A (Rhodopsin) Histamine HRH2 H2 Human Histamine Principal 1 Small molecule NCCc1cnc[nH]1 NTYJJOPFIAHURM-UHFFFAOYSA-N
A (Rhodopsin) Class A orphan LGR4 LGR4 Human R-Spondin-2 1 Peptide - - 12.5 12.5 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Neuropeptide Sf 3 Peptide - -
A (Rhodopsin) Prolactin-releasing peptide PRLHR PrRP Human Prrp-31 2 Peptide - - 9.0 9.1 9.2 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Rat Galanin-Like Peptide 2 Peptide - - Refs
A (Rhodopsin) Kisspeptin KISSR kisspeptin Human Kisspeptin-13 4 Peptide - AURRBCSZKDKGPU-WOUDKVOTSA-N 8.4 8.4 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Human 3-Iodothyronamine None 1 Small molecule NCCc1ccc(cc1)Oc1ccc(c(c1)I)O HCYGDNGLWSZCCA-UHFFFAOYSA-N
A (Rhodopsin) Chemokine CXCR6 CXCR6 Human Cxcl16 Principal 1 Peptide - - Refs
A (Rhodopsin) Neuromedin U NMUR1 NMU1 Human Neuromedin U-23 3 Peptide - -
A (Rhodopsin) Melanocortin MC5R MC5 Human Β-Msh 2 Peptide - -
A (Rhodopsin) Lysophospholipid (S1P) S1PR4 S1P4 Human Sphingosylphosphorylcholine 2 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(OCC[N+](C)(C)C)[O-])N)O JLVSPVFPBBFMBE-HXSWCURESA-N
A (Rhodopsin) Leukotriene OXER1 OXE Human 5s-Hete None 5 Small molecule CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O KGIJOOYOSFUGPC-JGKLHWIESA-N 6.5 6.9 7.2 Refs
A (Rhodopsin) P2Y P2RY6 P2Y6 Human Udp None 1 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O XCCTYIAWTASOJW-XVFCMESISA-N 6.5 6.5 Refs
A (Rhodopsin) Adren ADA2C α2C Human (-)-Adrenaline None 1 Small molecule CNC[C@@H](c1ccc(c(c1)O)O)O UCTWMZQNUQWSLP-VIFPVBQESA-N 7.6 7.6 4.9 5.4 5.8 Refs
A (Rhodopsin) Chemokine CCR7 CCR7 Mouse Ccl21a 2 Peptide - - Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Human Lte4 None 1 Small molecule CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N OTZRAYGBFWZKMX-FRFVZSDQSA-N
A (Rhodopsin) Class A orphan GPR12 GPR12 Human Sphingosine 1-Phosphate Principal 1 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O DUYSYHSSBDVJSM-KRWOKUGFSA-N 5.5 6.3 7.0 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Rat Phv 4 Peptide - - Refs
A (Rhodopsin) Opioid OPRK κ Human Dynorphin A 1 Peptide - JMNJYGMAUMANNW-FIXZTSJVSA-N 10.0 10.2 10.3 Refs
A (Rhodopsin) Class A orphan GPR39 GPR39 Human Obestatin Peptide - -
A (Rhodopsin) Neuromedin U NMUR2 NMU2 Human Neuromedin S-33 1 Peptide - - 10.0 10.0 Refs
A (Rhodopsin) Opioid OPRK κ Rat [Met]Enkephalin 8 Peptide - YFGBQHOOROIVKG-FKBYEOEOSA-N 6.0 6.0 Refs
A (Rhodopsin) Bombesin NMBR BB1 Human Grp-(18-27) 2 Peptide - -
A (Rhodopsin) Apelin APJ apelin Human Apelin-17 2 Peptide - SVWSKJCJNAIKNH-MJZUAXFLSA-N Refs
A (Rhodopsin) Complement peptide C3AR C3a Human C5a 2 Peptide - -
A (Rhodopsin) Leukotriene LT4R2 BLT2 Human 12s-Hpete 4 Small molecule CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)OO ZIOZYRSDNLNNNJ-LQWMCKPYSA-N
A (Rhodopsin) Bradykinin BKRB2 B2 Human [Des-Arg10]Kallidin 3 Peptide - AILVBOHFGXNHCC-TZPCGENMSA-N
A (Rhodopsin) Opioid OPRM μ Human [Met]Enkephalin 1 Peptide - YFGBQHOOROIVKG-FKBYEOEOSA-N 9.2 9.2 Refs
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Rat Cck-8 1 Peptide - IZTQOLKUZKXIRV-YRVFCXMDSA-N Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl5 3 Peptide - - Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl2 3 Peptide - - Refs
A (Rhodopsin) Bombesin GRPR BB2 Human Gastrin-Releasing Peptide 1 Peptide - BNEIPTFKHBHJBM-XKNFJVFFSA-N 6.3 7.3 8.2 Refs
A (Rhodopsin) Proteinase-activated PAR4 PAR4 Human Thrombin Peptide - -
A (Rhodopsin) Melanocortin MC5R MC5 Mouse Agouti 2 Peptide - - Refs
A (Rhodopsin) Glycoprotein hormone LSHR LH Human Lh 2 Peptide - - Refs
A (Rhodopsin) Class A orphan GPR31 GPR31 Human 12s-Hete Principal 1 Small molecule CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)O ZNHVWPKMFKADKW-LQWMCKPYSA-N
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide W-30 5 Peptide - -
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl7 3 Peptide - - Refs
A (Rhodopsin) Chemokine CXCR4 CXCR4 Human Cxcl12Β 2 Peptide - - Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Cxcl11 9 Peptide - -
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Rat Peptide Yy 2 Peptide - IXMRLEGHWROJAA-HDTKZREISA-N 9.0 9.0 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Human Pgd3 None 2 Small molecule CCC=CC[C@@H](C=C[C@H]1C(=O)C[C@@H]([C@@H]1CC=CCCCC(=O)O)O)O ANOICLBSJIMQTA-MLHJIOFPSA-N
A (Rhodopsin) Dopamine DRD5 D5 Human 5-Hydroxytryptamine None 2 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 5.5 5.5 Refs
A (Rhodopsin) Apelin APJ apelin Human Elabela/Toddler-32 2 Peptide - AXGBCVTUKUUUPN-PXWSXZDTSA-N
A (Rhodopsin) Melanocortin MC4R MC4 Mouse Agouti 3 Peptide - - Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Prp106-126 None 8 Peptide - XPZWWTIIKSODDO-MBNDGZRNSA-N 4.6 4.6 Refs
A (Rhodopsin) Prostanoid PD2R DP1 Human Thromboxane A2 6 Small molecule CCCCC[C@@H](/C=C/[C@H]1O[C@H]2C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O2)O DSNBHJFQCNUKMA-SCKDECHMSA-N
A (Rhodopsin) Dopamine DRD1 D1 Human 5-Hydroxytryptamine None 1 Small molecule NCCc1c[nH]c2c1cc(O)cc2 QZAYGJVTTNCVMB-UHFFFAOYSA-N 5.0 5.0 Refs
F (Frizzled) Frizzled FZD6 FZD6 Human Wnt-5a Peptide - - Refs
A (Rhodopsin) Neuropeptide Y NPY2R Y2 Human Pancreatic Polypeptide 5 Peptide - -
A (Rhodopsin) Chemokine CCR3 CCR3 Human Cxcl10 5 Peptide - -
A (Rhodopsin) Galanin GALR1 GAL1 Human Galanin-Like Peptide 2 Peptide - - Refs
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Pth 5 Peptide - -
A (Rhodopsin) Opioid OPRK κ Rat [Leu]Enkephalin 8 Peptide - URLZCHNOLZSCCA-UHFFFAOYSA-N 6.0 6.0 Refs
B1 (Secretin) Glucagon receptor family GLP1R GLP-1 Human Glucagon-Like Peptide 1-(7-36) Amide 1 Peptide - - 9.2 9.2 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Ghrh 4 Peptide - -
A (Rhodopsin) Neuropeptide Y NPY2R Y2 Human Peptide Yy 1 Peptide - IXMRLEGHWROJAA-HDTKZREISA-N 10.0 10.0 Refs
A (Rhodopsin) Bradykinin BKRB2 B2 Human [Hyp3]Bradykinin 3 Peptide - -
B1 (Secretin) VIP and PACAP PACR PAC1 Human Phv 4 Peptide - -
A (Rhodopsin) Melanocortin MC4R MC4 Human Γ-Msh 3 Peptide - -
A (Rhodopsin) Prostanoid PD2R DP1 Human Pgi2 6 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O KAQKFAOMNZTLHT-OZUDYXHBSA-N
A (Rhodopsin) Opioid OPRD δ Human Dynorphin A-(1-13) 4 Peptide - OVVIBUHLQIYUEU-IWIISZHXSA-N 7.8 7.8 Refs
A (Rhodopsin) Peptide P518 QRFPR QRFP Rat Qrfp26 5 Peptide - - Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl4 8 Peptide - -
A (Rhodopsin) Opioid OPRD δ Human Endomorphin-1 6 Peptide - ZEXLJFNSKAHNFH-SYKYGTKKSA-N 6.1 6.1 Refs
A (Rhodopsin) Angiotensin AGTR1 AT1 Human Angiotensin A 1 Peptide - CHCOFDZSJYMQMX-NOQNJSOHSA-N 8.2 8.2 8.8 8.8 Refs
A (Rhodopsin) Formylpeptide FPR3 FPR3 Human F2l 4 Peptide - -
A (Rhodopsin) Free fatty acid FFAR2 FFA2 Human Trans-2-Methylcrotonic Acid None 3 Small molecule C/C(=C\C)/C(=O)O UIERETOOQGIECD-ONEGZZNKSA-N 3.8 3.8 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl7 5 Peptide - -
A (Rhodopsin) Class A orphan GPR31 GPR31 Mouse 12s-Hete Principal 1 Small molecule CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)O ZNHVWPKMFKADKW-LQWMCKPYSA-N 9.6 9.6 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Cxcl9 5 Peptide - -
F (Frizzled) Frizzled FZD4 FZD4 Mouse Norrin Principal 1 Peptide - - Refs
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Rat Pthrp-(1-34) (Human) None 4 Peptide - ZOWOHMFPXMYFKJ-WBTWNKCNSA-N Refs
A (Rhodopsin) Class A orphan GPR63 GPR63 Human Sphingosine 1-Phosphate None 3 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O DUYSYHSSBDVJSM-KRWOKUGFSA-N 6.1 6.2 6.2 Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Acth 2 Peptide - -
A (Rhodopsin) Prolactin-releasing peptide PRLHR PrRP Human Prrp-20 4 Peptide - -
B1 (Secretin) Glucagon receptor family GHRHR GHRH Human Ghrh Principal 1 Peptide - -
A (Rhodopsin) Prostanoid PI2R IP Human Thromboxane A2 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1O[C@H]2C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O2)O DSNBHJFQCNUKMA-SCKDECHMSA-N
A (Rhodopsin) Class A orphan GP183 GPR183 Human 7Β-Hydroxycholesterol None 7 Small molecule CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@@H](O)C=C2[C@]1(C)CC[C@@H](C2)O)C)C OYXZMSRRJOYLLO-KGZHIOMZSA-N 5.8 5.8 Refs
A (Rhodopsin) Chemokine CXCR5 CXCR5 Human Cxcl13 Principal 1 Peptide - - Refs
A (Rhodopsin) Prostanoid PI2R IP Human Pgf2Α 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O PXGPLTODNUVGFL-YNNPMVKQSA-N
A (Rhodopsin) Class A orphan LGR4 LGR4 Human R-Spondin-1 2 Peptide - - 10.7 10.7 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl4 8 Peptide - -
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl11 8 Peptide - - Refs
A (Rhodopsin) Hydroxycarboxylic acid HCAR2 HCA2 Human Butyric Acid None 2 Small molecule CCCC(=O)O FERIUCNNQQJTOY-UHFFFAOYSA-N 2.8 2.8
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Annexin I 9 Peptide - -
B1 (Secretin) Glucagon receptor family GIPR GIP Rat Gastric Inhibitory Polypeptide Principal 1 Peptide - - Refs
F (Frizzled) Frizzled FZD1 FZD1 Human Wnt-3a Peptide - -
A (Rhodopsin) Chemokine XCR1 XCR1 Human Xcl2 1 Peptide - - 7.3 7.3 Refs
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Gastrin-17 2 Peptide - -
A (Rhodopsin) Melanocortin MSHR MC1 Human Β-Msh 2 Peptide - -
B1 (Secretin) Calcitonin CALCR CT Human Calcitonin 7 Peptide - -
A (Rhodopsin) Class A orphan G37L1 GPR37L1 Human Prosaptide Principal 1 Peptide - KSDDQEGWVBODMD-OULINLAESA-N 8.3 8.3 Refs
A (Rhodopsin) Class A orphan GP139 GPR139 Human L-Tryptophan None 1 Small molecule OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N QIVBCDIJIAJPQS-VIFPVBQESA-N 3.7 3.7 3.1 3.1 Refs
A (Rhodopsin) Class A orphan GP183 GPR183 Human 7Β, 27-Dihydroxycholesterol None 4 Small molecule OC[C@@H](CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@@H](O)C=C2[C@]1(C)CC[C@@H](C2)O)C)C RXMHNAKZMGJANZ-BMOLSTJGSA-N 7.3 7.3 Refs
A (Rhodopsin) Melanocortin MC4R MC4 Human Β-Msh 3 Peptide - -
B1 (Secretin) Glucagon receptor family GLP2R GLP-2 Rat Glucagon-Like Peptide 2-(2-33) 3 Peptide - OQGQYLSDVZWIPO-QSSAVJFTSA-N 6.1 6.1 Refs
A (Rhodopsin) Adren ADA1D α1D Rat (-)-Adrenaline None 1 Small molecule CNC[C@@H](c1ccc(c(c1)O)O)O UCTWMZQNUQWSLP-VIFPVBQESA-N 6.7 7.2 7.7 5.3 6.3 6.3 Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Ccl13 4 Peptide - - 7.2 7.2 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl11 5 Peptide - -
A (Rhodopsin) Lysophospholipid (S1P) S1PR3 S1P3 Human Dihydrosphingosine 1-Phosphate 2 Small molecule CCCCCCCCCCCCCCC[C@H]([C@H](COP(=O)(O)O)N)O YHEDRJPUIRMZMP-ZWKOTPCHSA-N
C (Glutamate) Metabotropic glutamate GRM7 mGlu7 Human L-Serine-O-Phosphate None 1 Small molecule OC(=O)[C@H](COP(=O)(O)O)N BZQFBWGGLXLEPQ-REOHCLBHSA-N 4.5 4.5 4.4 4.4 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Cxcl11 5 Peptide - -
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl2 8 Peptide - -
A (Rhodopsin) Tachykinin NK1R NK1 Human Hemokinin 1 4 Peptide - -
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl28 5 Peptide - -
A (Rhodopsin) Melanocortin MC4R MC4 Human Agouti-Related Protein 3 Peptide - - Refs
A (Rhodopsin) Neuromedin U NMUR1 NMU1 Human Neuromedin S-36 3 Peptide - -
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human Ribosomal Protein S19 2 Peptide - - Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR4 LPA4 Mouse Lpa None 1 Small molecule CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)(O)O)O WRGQSWVCFNIUNZ-KTKRTIGZSA-N Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl3 8 Peptide - -
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Qrfp43 (43rfa) 3 Peptide - -
A (Rhodopsin) Lysophospholipid (LPA) LPAR4 LPA4 Human Farnesyl Diphosphate None 2 Small molecule C/C(=C/COP(=O)(OP(=O)(O)O)O)/CC/C=C(\CCC=C(C)C)/C VWFJDQUYCIWHTN-FBXUGWQNSA-N Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Desulfated Gastrin-17 5 Peptide - GKDWRERMBNGKCZ-RNXBIMIWSA-N
C (Glutamate) Class C Orphan GPC6A GPRC6 Human L-Lysine None 3 Small molecule NCCCC[C@@H](C(=O)O)N KDXKERNSBIXSRK-YFKPBYRVSA-N 3.8 3.8 Refs
A (Rhodopsin) Leukotriene OXER1 OXE Human 5-Oxo-Ode None 2 Small molecule CCCCCCCCC/C=C\C=C\C(=O)CCCC(=O)O YVWMHFYOIJMUMN-HSINTONASA-N 8.0 8.0 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Human Pancreatic Polypeptide 7 Peptide - -
A (Rhodopsin) Galanin GALR1 GAL1 Human Galanin-Like Peptide 2 Peptide - -
A (Rhodopsin) Class A orphan GPR6 GPR6 Human Sphingosine 1-Phosphate Principal 1 Small molecule CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O DUYSYHSSBDVJSM-KRWOKUGFSA-N
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl28 5 Peptide - -
A (Rhodopsin) Hydroxycarboxylic acid HCAR2 HCA2 Human Β-D-Hydroxybutyric Acid None 1 Small molecule C[C@H](CC(=O)O)O WHBMMWSBFZVSSR-GSVOUGTGSA-N 3.5 3.5 Refs
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C5a 2 Peptide - -
A (Rhodopsin) Class A orphan TAAR3 TAAR3 Mouse Isoamylamine Principal 1 Small molecule NCCC(C)C BMFVGAAISNGQNM-UHFFFAOYSA-N 5.0 5.0 Refs
C (Glutamate) GABAB GABR1 GABAB1 Human Gaba Principal 1 Small molecule NCCCC(=O)O BTCSSZJGUNDROE-UHFFFAOYSA-N
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Neuropeptide Af 3 Peptide - YPBGORNZMUQFSF-KWFINLGMSA-N
A (Rhodopsin) Opioid OPRK κ Human Big Dynorphin 9 Peptide - VPZXNPNLCOYTOT-MBGMINRZSA-N
A (Rhodopsin) GPR18, GPR55 and GPR119 GP119 GPR119 Human Anandamide 2 Small molecule CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCO LGEQQWMQCRIYKG-DOFZRALJSA-N
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Secretin 4 Peptide - KKNIUBFRGPFELP-UHFFFAOYSA-N
A (Rhodopsin) P2Y P2Y13 P2Y13 Human Adp None 1 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N XTWYTFMLZFPYCI-KQYNXXCUSA-N Refs
A (Rhodopsin) Prostanoid PD2R DP1 Human Pgj2 None 1 Small molecule CCCCC[C@@H](/C=C/[C@@H]1[C@@H](C/C=C\CCCC(=O)O)C=CC1=O)O UQOQENZZLBSFKO-POPPZSFYSA-N 9.0 9.0 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Mouse Cortistatin-14 4 Peptide - - 8.7 9.1 9.4 Refs
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Desulfated Cholecystokinin-8 2 Peptide - ZBTPHEHKAHBSMT-YRVFCXMDSA-N
A (Rhodopsin) Neurotensin NTR1 NTS1 Human Large Neuromedin N 3 Peptide - - Refs
A (Rhodopsin) Tachykinin NK2R NK2 Human Neuropeptide Γ 4 Peptide - -
A (Rhodopsin) Lysophospholipid (LPA) LPAR5 LPA5 Human N-Arachidonoylglycine None 4 Small molecule CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCC(=O)O YLEARPUNMCCKMP-DOFZRALJSA-N 4.3 4.3 Refs
A (Rhodopsin) Kisspeptin KISSR kisspeptin Human Kisspeptin-10 5 Peptide - -
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl3 7 Peptide - -
A (Rhodopsin) Melanin-concentrating hormon MCHR2 MCH2 Human Melanin-Concentrating Hormone Principal 1 Peptide - ORRDHOMWDPJSNL-UHFFFAOYSA-N Refs
A (Rhodopsin) Leukotriene LT4R1 BLT1 Human 12r-Hete None 3 Small molecule CCCCC/C=C\C[C@H](/C=C/C=C\C/C=C\CCCC(=O)O)O ZNHVWPKMFKADKW-ZYBDYUKJSA-N 7.5 7.5 Refs
B1 (Secretin) Calcitonin CALCR CT Human Amylin 7 Peptide - -
A (Rhodopsin) Opioid OPRK κ Mouse Dynorphin A 1 Peptide - JMNJYGMAUMANNW-FIXZTSJVSA-N 10.0 10.2 10.3 Refs
B1 (Secretin) Calcitonin CALCR CT Human Β-Cgrp 5 Peptide - - 7.2 7.2 Refs
C (Glutamate) Metabotropic glutamate GRM3 mGlu3 Human Naag None 2 Small molecule OC(=O)CC[C@@H](C(=O)O)NC(=O)[C@@H](NC(=O)C)CC(=O)O OPVPGKGADVGKTG-BQBZGAKWSA-N 4.7 4.7 Refs
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C3a 2 Peptide - -
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl8 5 Peptide - -
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Cck-4 4 Peptide - RGYLYUZOGHTBRF-UHFFFAOYSA-N Refs
A (Rhodopsin) Adren ADRB2 β2 Human Noradrenaline None 3 Small molecule NCC(c1ccc(c(c1)O)O)O SFLSHLFXELFNJZ-UHFFFAOYSA-N 5.4 5.4 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Human Pgi2 5 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O KAQKFAOMNZTLHT-OZUDYXHBSA-N
A (Rhodopsin) Orexin OX2R OX2 Human Orexin-B 2 Peptide - WGMOJBHHMACBCG-GWQFQBPDSA-N
A (Rhodopsin) Prolactin-releasing peptide PRLHR PrRP Human Prrp-31 4 Peptide - -
A (Rhodopsin) Urotensin UR2R UT Rat Urotensin-Ii 1 Peptide - - 8.8 8.8 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Rfrp-1 3 Peptide - -
A (Rhodopsin) Bradykinin BKRB1 B1 Rat T-Kinin 5 Peptide - GKCWYHPGFSRBQV-WRBAKOPXSA-N 5.0 5.1 5.2 Refs
A (Rhodopsin) Class A orphan GP183 GPR183 Human 7Α-Hydroxycholesterol None 5 Small molecule CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@H](O)C=C2[C@]1(C)CC[C@@H](C2)O)C)C OYXZMSRRJOYLLO-RVOWOUOISA-N 7.1 7.1 Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Β-Msh 2 Peptide - -
B1 (Secretin) Calcitonin CALCR CT Human Β-Cgrp 7 Peptide - -
A (Rhodopsin) Bombesin NMBR BB1 Human Gastrin-Releasing Peptide 2 Peptide - -
A (Rhodopsin) Chemokine CCR7 CCR7 Mouse Ccl19 2 Peptide - - Refs
A (Rhodopsin) Prostanoid PI2R IP Human Pgd2 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O BHMBVRSPMRCCGG-OUTUXVNYSA-N
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide B-23 5 Peptide - -
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Neuropeptide Sf 3 Peptide - -
A (Rhodopsin) Chemokine CX3C1 CX3CR1 Human Cx3Cl1 Principal 1 Peptide - -
A (Rhodopsin) Bile acid GPBAR GPBA Human Cholic Acid None 4 Small molecule O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C BHQCQFFYRZLCQQ-OELDTZBJSA-N 5.0 5.0 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Cck-58 5 Peptide - -
A (Rhodopsin) Chemokine CCR4 CCR4 Human Ccl17 2 Peptide - - Refs
A (Rhodopsin) Melanocortin MC3R MC3 Mouse Agouti 3 Peptide - - Refs
F (Frizzled) Frizzled FZD2 FZD2 Human Wnt-5a Principal 1 Peptide - -
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Ccl7 Peptide - -
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Desulfated Cholecystokinin-8 None 3 Peptide - ZBTPHEHKAHBSMT-YRVFCXMDSA-N Refs
A (Rhodopsin) Galanin GALR2 GAL2 Human Galanin-Like Peptide 4 Peptide - -
A (Rhodopsin) Adenosine AA1R A1 Human Adenosine Principal 1 Small molecule OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N OIRDTQYFTABQOQ-KQYNXXCUSA-N 7.0 7.0 Refs
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM5 M5 Human Acetylcholine Principal 1 Small molecule CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 6.1 6.1 Refs
A (Rhodopsin) Melanocortin MC3R MC3 Human Β-Msh 3 Peptide - -
A (Rhodopsin) Leukotriene OXER1 OXE Human 5s-Hpete None 4 Small molecule CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)OO JNUUNUQHXIOFDA-JGKLHWIESA-N 7.0 7.0 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl4 7 Peptide - -
A (Rhodopsin) Melanocortin MSHR MC1 Human Β-Msh 2 Peptide - -
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C5a Des-Arg 2 Peptide - - Refs
A (Rhodopsin) Prolactin-releasing peptide PRLHR PrRP Human Pthrp 4 Peptide - -
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl7 8 Peptide - -
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl7 7 Peptide - -
A (Rhodopsin) P2Y P2Y11 P2Y11 Human Utp None 1 Small molecule O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O PGAVKCOVUIYSFO-XVFCMESISA-N 5.2 5.2 Refs
A (Rhodopsin) Relaxin family peptide RL3R1 RXFP3 Human Relaxin-3 (B Chain) 3 Peptide - - Refs
A (Rhodopsin) Tachykinin NK2R NK2 Human Hemokinin 1 4 Peptide - -
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Ghrh 4 Peptide - -
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl8 8 Peptide - -
B1 (Secretin) Parathyroid hormone PTH1R PTH1 Human Pth 3 Peptide - -
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl3 7 Peptide - -
B1 (Secretin) Glucagon receptor family GLP2R GLP-2 Rat Glucagon-Like Peptide 2 1 Peptide - JPRUMPQGPCFDGW-CWHSZFSPSA-N 10.2 10.2 Refs
A (Rhodopsin) Neuromedin U NMUR2 NMU2 Human Neuromedin U-23 3 Peptide - -
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Pthrp-(1-36) 3 Peptide - NNRMZXDHMCWWRV-RHBZDGMUSA-N Refs
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Rat Pyy-(3-36) 3 Peptide - - 8.4 8.4 Refs
B1 (Secretin) Glucagon receptor family SCTR secretin Human Vip 2 Peptide - VBUWHHLIZKOSMS-UHFFFAOYSA-N Refs
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Human Peptide Yy 6 Peptide - -
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Ghrh 4 Peptide - - 6.2 6.2 Refs
F (Frizzled) Frizzled FZD1 FZD1 Human Wnt-1 Peptide - -
A (Rhodopsin) Tachykinin NK3R NK3 Mouse Hemokinin 1 3 Peptide - - 9.2 9.3 9.3 Refs
A (Rhodopsin) Prokineticin PKR1 PKR1 Human Prokineticin-1 4 Peptide - -
A (Rhodopsin) Class A orphan LGR5 LGR5 Human R-Spondin-4 4 Peptide - - 9.4 9.4 Refs
B1 (Secretin) Glucagon receptor family GLP2R GLP-2 Rat Glucagon-Like Peptide 2-(3-33) 2 Peptide - JHPPUNFVXZAAKU-YNDCLQMTSA-N 6.6 6.6 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl7 8 Peptide - -
A (Rhodopsin) Prostanoid TA2R TP Human Pgh2 3 Small molecule CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OO[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O YIBNHAJFJUQSRA-YNNPMVKQSA-N