Data showed in this table is continously collected from the Guide to Pharmacology database. Ref

RECEPTOR ENDOGENOUS LIGANDS pEC50 pKi REFERENCES
Class Receptor family UniProt IUPHAR Species Ligand GtP
Classification
Potency
Ranking
Type Min Mid Max Min Mid Max
A (Rhodopsin) Opioid OPRK κ Human Α-Neoendorphin 4 Peptide 8.9 9.5 10.0 Refs
A (Rhodopsin) Vasopressin and oxytocin V1BR V1B Human Vasopressin 1 Peptide 9.0 9.3 9.5 Refs
A (Rhodopsin) Relaxin family peptide RXFP2 RXFP2 Human Relaxin-1 2 Peptide 8.8 8.8 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl7 3 Peptide 8.1 8.1 Refs
C (Glutamate) Calcium-sensing CASR CaS Mouse Ca2+ None 2 Small molecule Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Pge2 None 1 Small molecule 7.3 7.7 7.7 Refs
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Human Peptide Yy 6 Peptide
A (Rhodopsin) Apelin APJ apelin Human Elabela/Toddler-32 2 Peptide
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl4 8 Peptide
A (Rhodopsin) Histamine HRH3 H3 Rat Histamine Principal 1 Small molecule 7.8 8.1 8.3 Refs
A (Rhodopsin) Class A orphan GPR35 GPR35 Human Kynurenic Acid Principal 1 Small molecule 3.9 5.0 5.0 Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Agouti-Related Protein 2 Peptide Refs
A (Rhodopsin) Melatonin MTR1A MT1 Human Melatonin Principal 1 Small molecule 9.1 9.4 9.7 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Rat Srif-14 3 Peptide 8.7 8.9 8.9 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT2C 5-HT2C Human 5-Hydroxytryptamine Principal 1 Small molecule 6.8 7.7 8.6 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Rat Srif-28 2 Peptide 8.4 9.3 10.2 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Rat Pacap-27 2 Peptide 7.6 8.5 9.4 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT6R 5-HT6 Human 5-Hydroxytryptamine Principal 1 Small molecule 6.6 7.3 7.9 Refs
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM3 M3 Rat Acetylcholine Principal 1 Small molecule 4.5 5.0 5.4 Refs
A (Rhodopsin) Chemokine CXCR1 CXCR1 Human Cxcl8 1 Peptide 8.8 9.2 9.5 Refs
A (Rhodopsin) Motilin MTLR motilin Human Motilin Principal 1 Peptide 8.4 8.6 8.7 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Rat Oxytocin 2 Peptide 6.9 6.1 6.1 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Human Udp-Glucose None 1 Small molecule 7.7 7.7 Refs
A (Rhodopsin) Bombesin NMBR BB1 Human Neuromedin B 1 Peptide 8.1 9.2 10.3 Refs
A (Rhodopsin) P2Y P2RY4 P2Y4 Rat Atp None 2 Small molecule 5.7 6.0 6.3 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Mouse Srif-14 1 Peptide 9.0 9.1 9.1 8.9 9.7 10.5 Refs
A (Rhodopsin) Adren ADA1B α1B-adren Human (-)-Noradrenaline None 2 Small molecule 6.2 6.2 Refs
B1 (Secretin) Parathyroid hormone PTH1R PTH1 Human Pth 3 Peptide
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Neuropeptide Af 3 Peptide
C (Glutamate) Calcium-sensing CASR CaS Rat Ca2+ None 2 Small molecule Refs
A (Rhodopsin) Vasopressin and oxytocin OXYR OT Human Oxytocin 1 Peptide 8.2 8.9 9.6 Refs
A (Rhodopsin) Orexin OX2R OX2 Human Orexin-A 1 Peptide 6.5 8.3 10.0 Refs
A (Rhodopsin) Relaxin family peptide RL3R2 RXFP4 Human Insl5 3 Peptide 7.0 7.7 8.9 7.3 8.1 8.8 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1B 5-HT1B Mouse 5-Hydroxytryptamine None 1 Small molecule 7.4 8.2 9.0 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR5 S1P5 Mouse Sphingosine 1-Phosphate None 1 Small molecule 7.8 7.9 7.9 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Human Srif-28 2 Peptide 8.1 9.1 9.1 Refs
A (Rhodopsin) Kisspeptin KISSR kisspeptin Human Kisspeptin-13 4 Peptide 8.4 8.4 Refs
B1 (Secretin) Calcitonin CALCR CT Human Calcitonin (Salmon) None 2 Peptide 7.6 9.4 11.1 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Human Cst-17 2 Peptide 8.8 9.1 9.3 Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Mouse Ltd4 None 2 Small molecule 8.1 9.2 9.2 Refs
A (Rhodopsin) Chemerin CML1 hemerin Human Resolvin E1 None 2 Small molecule Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT2A 5-HT2A Human 5-Hydroxytryptamine None 2 Small molecule 6.0 6.3 6.5 Refs
A (Rhodopsin) Vasopressin and oxytocin V1BR V1B Rat Vasopressin 1 Peptide 9.0 9.3 9.5 Refs
A (Rhodopsin) Angiotensin AGTR1 AT1 Human Angiotensin Iv 2 Peptide 5.9 5.9 Refs
A (Rhodopsin) Adren Q3UP63 β3-adren Mouse (&Plusmn;)-Adrenaline None 1 Small molecule 3.9 4.3 4.7 Refs
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM1 M1 Human Acetylcholine Principal 1 Small molecule 4.3 5.0 5.0 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Rat Peptide Yy 5 Peptide 6.3 7.0 8.5 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT7R 5-HT7 Rat 5-Hydroxytryptamine Principal 1 Small molecule 8.7 9.0 9.2 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1D 5-HT1D Human 5-Ht-Moduline None 2 Peptide Refs
A (Rhodopsin) Adenosine AA3R A3 Human Adenosine Principal 1 Small molecule 5.2 5.2 Refs
A (Rhodopsin) Leukotriene OXER1 OXE Human 5s-Hpete None 4 Small molecule 7.0 7.0 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Mouse Tyramine None 1 Small molecule 6.9 7.1 7.2 7.2 7.2 Refs
A (Rhodopsin) Tachykinin NK3R NK3 Mouse Neurokinin B 1 Peptide 8.4 8.4 8.6 8.7 8.7 Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Mouse Udp-Galactose None 4 Small molecule 6.0 7.5 8.9 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Cck-8 1 Peptide Refs
C (Glutamate) Metabotropic glutamate GRM3 mGlu3 Human Naag None 2 Small molecule 4.7 4.7 Refs
A (Rhodopsin) Bombesin NMBR BB1 Human Grp-(18-27) 2 Peptide
A (Rhodopsin) Class A orphan GPR63 GPR63 Human Sphingosine 1-Phosphate None 2 Small molecule 6.1 6.2 6.2 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl2 6 Peptide 7.5 7.5 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Rat Srif-14 1 Peptide 9.0 9.1 9.1 8.9 9.7 10.5 Refs
A (Rhodopsin) Leukotriene LT4R2 BLT2 Human 15s-Hete None 2 Small molecule 7.5 7.5 Refs
A (Rhodopsin) Platelet-activating factor PTAFR PAF Human Methylcarbamyl Paf None 2 Small molecule
A (Rhodopsin) Neuropeptide Y NPY2R Y2 Human Neuropeptide Y-(3-36) 5 Peptide
A (Rhodopsin) Leukotriene OXER1 OXE Human 5-Oxo-15-Hete None 3 Small molecule 7.7 7.7 Refs
A (Rhodopsin) Opioid OPRM μ Human Dynorphin A-(1-8) 3 Peptide 8.4 8.4 Refs
A (Rhodopsin) Prostanoid PI2R IP Mouse Pge1 None 2 Small molecule 6.5 6.7 6.8 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Rat Srif-14 3 Peptide 8.4 9.2 9.9 Refs
C (Glutamate) Metabotropic glutamate GRM1 mGlu1 Rat L-Glutamic Acid Principal 1 Small molecule 4.8 4.9 5.0 6.4 6.5 6.5 Refs
A (Rhodopsin) Opioid OPRK κ Mouse Dynorphin A 2 Peptide 8.3 9.6 10.8 Refs
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Desulfated Cholecystokinin-8 2 Peptide
A (Rhodopsin) P2Y P2Y12 P2Y12 Human Atp 2 Small molecule
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Human Neuropeptide Y 1 Peptide 9.1 9.1 Refs
A (Rhodopsin) Opioid OPRK κ Rat Dynorphin A 2 Peptide 8.3 9.6 10.8 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Mouse Srif-28 2 Peptide 8.4 9.3 10.2 Refs
A (Rhodopsin) Orexin OX1R OX1 Human Orexin-A 1 Peptide 6.5 8.4 10.2 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl26 5 Peptide Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT5A 5-HT5A Mouse 5-Hydroxytryptamine Principal 1 Small molecule 6.7 6.8 6.9 Refs
A (Rhodopsin) Prostanoid PD2R DP1 Human Pge2 None 4 Small molecule 6.5 6.8 7.0 Refs
A (Rhodopsin) Chemokine ACKR4 ACKR4 Human Ccl19 1 Peptide 8.5 8.8 9.1 8.4 8.4 Refs
A (Rhodopsin) Glycoprotein hormone TSHR TSH Human Tsh Principal 1 Peptide
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Pgd2 None 2 Small molecule 8.8 8.8 8.7 5.9 5.9 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Human Pge1 None 1 Small molecule 9.4 9.4 9.0 9.0 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT2C 5-HT2C Rat 5-Hydroxytryptamine Principal 1 Small molecule 6.8 7.7 8.6 Refs
C (Glutamate) Metabotropic glutamate GRM4 mGlu4 Rat L-Serine-O-Phosphate None 1 Small molecule 5.9 5.9 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Human Corticotrophin-Releasing Hormone 1 Peptide 7.8 7.8 Refs
A (Rhodopsin) Bradykinin BKRB2 B2 Human Kallidin 1 Peptide Refs
A (Rhodopsin) Histamine HRH4 H4 Human Histamine None 1 Small molecule 7.8 7.4 7.4 Refs
B2 (Adhesion) ADGRL AGRL1 ADGRL1 Human Lasso D Principal 1 Peptide
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Pge1 None 1 Small molecule 9.5 9.5 8.7 8.7 Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Prp106-126 None 8 Peptide 4.6 4.6 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Human Vasopressin 1 Peptide 8.5 8.9 9.3 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Cxcl11 5 Peptide
C (Glutamate) Metabotropic glutamate GRM3 mGlu3 Human L-Glutamic Acid None 1 Small molecule 5.3 5.4 5.4 6.4 6.4 Refs
A (Rhodopsin) Neurotensin NTR1 NTS1 Human Large Neuromedin N 3 Peptide Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl5 8 Peptide
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Qrfp43 (43rfa) 3 Peptide
A (Rhodopsin) Bradykinin BKRB1 B1 Rat Bradykinin 4 Peptide 5.1 5.2 5.3 Refs
A (Rhodopsin) Prostanoid TA2R TP Human Pgf None 1 Small molecule 5.1 5.1 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Rat Pancreatic Polypeptide 1 Peptide 10.3 10.6 10.8 Refs
A (Rhodopsin) Class A orphan P2Y10 P2RY10 Human Lpa None 2 Small molecule 6.9 6.9 Refs
A (Rhodopsin) Vasopressin and oxytocin OXYR OT Human Vasopressin 2 Peptide 7.3 8.3 9.3 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1B 5-HT1B Human 5-Hydroxytryptamine None 1 Small molecule 7.4 8.2 9.0 Refs
A (Rhodopsin) Bombesin GRPR BB2 Human Neuromedin B 2 Peptide 6.6 7.0 7.4 Refs
A (Rhodopsin) Free fatty acid FFAR2 FFA2 Human Butyric Acid None 3 Small molecule 2.9 3.8 4.6 Refs
A (Rhodopsin) Tachykinin NK2R NK2 Human Neurokinin A 1 Peptide 8.0 8.6 9.1 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT7R 5-HT7 Mouse 5-Hydroxytryptamine Principal 1 Small molecule 8.7 9.0 9.2 Refs
A (Rhodopsin) Kisspeptin KISSR kisspeptin Human Kisspeptin-10 5 Peptide
A (Rhodopsin) Urotensin UR2R UT Human Urotensin-Ii 2 Peptide 8.6 8.6 Refs
A (Rhodopsin) Opioid OPRD δ Human Β-Endorphin 7 Peptide
A (Rhodopsin) Galanin GALR1 GAL1 Rat Galanin 1 Peptide 9.8 9.8 9.3 9.8 10.3 Refs
A (Rhodopsin) Galanin GALR1 GAL1 Mouse Galanin 1 Peptide 9.8 9.8 9.3 9.8 10.3 Refs
A (Rhodopsin) Complement peptide C3AR C3a Human C3a 2 Peptide
A (Rhodopsin) Bombesin NMBR BB1 Human Gastrin-Releasing Peptide 2 Peptide
A (Rhodopsin) Histamine HRH3 H3 Mouse Histamine Principal 1 Small molecule 7.8 8.1 8.3 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR5 S1P5 Human Sphingosine 1-Phosphate None 1 Small molecule 7.8 7.9 7.9 Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Human Ltc4 None 3 Small molecule 7.8 8.7 9.5 Refs
C (Glutamate) Class C Orphan GPC6A GPRC6 Human L-Serine None 5 Small molecule 3.2 3.2 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Human Oxytocin 2 Peptide 6.9 6.1 6.1 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl3 8 Peptide
A (Rhodopsin) Chemokine CCR10 CCR10 Human Ccl28 Peptide
A (Rhodopsin) Prolactin-releasing peptide PRLHR PrRP Human Prrp-31 2 Peptide 9.0 9.1 9.2 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR5 LPA5 Human Farnesyl Diphosphate None 2 Small molecule 5.8 6.2 6.5 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Rat Pgf None 3 Small molecule 5.2 5.6 5.6 Refs
A (Rhodopsin) Tachykinin NK1R NK1 Human Neurokinin A 2 Peptide 6.2 7.8 9.3 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR5 LPA5 Human Lpa None 3 Small molecule 4.3 6.1 7.9 Refs
A (Rhodopsin) Opioid OPRK κ Human Dynorphin A 2 Peptide 8.3 9.6 10.8 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Desulfated Gastrin-71 5 Peptide
A (Rhodopsin) Somatostatin SSR5 SST5 Mouse Srif-28 1 Peptide 9.2 9.8 10.3 Refs
A (Rhodopsin) Free fatty acid FFAR3 FFA3 Human Propanoic Acid None 1 Small molecule 3.9 4.8 5.7 Refs
A (Rhodopsin) Adren ADA2C α2C-adren Human (-)-Noradrenaline None 1 Small molecule 5.7 6.3 6.8 Refs
A (Rhodopsin) Class A orphan LGR6 LGR6 Human R-Spondin-3 Peptide Refs
A (Rhodopsin) Gonadotrophin-releasing hormone GNRHR GnRH1 Human Gnrh I 1 Peptide 7.8 7.9 7.9 7.3 8.0 8.4 Refs
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Rat Pthrp-(1-34) (Human) None 4 Peptide Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Human Pge1 None 1 Small molecule 8.0 8.0 Refs
A (Rhodopsin) Hydroxycarboxylic acid HCAR3 HCA3 Human 3-Hydroxyoctanoic Acid Principal 1 Small molecule 5.1 5.1 Refs
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM3 M3 Human Acetylcholine Principal 1 Small molecule 4.5 5.0 5.4 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Pgf None 3 Small molecule 6.1 6.1 9.1 6.2 6.2 Refs
A (Rhodopsin) Prostanoid PD2R DP1 Human Pgd2 None 2 Small molecule 7.8 8.5 9.2 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Human Srif-14 3 Peptide 8.7 8.9 8.9 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl4 1 Peptide 9.4 9.5 9.6 Refs
A (Rhodopsin) Oxoglutarate OXGR1 xoglutarate Human Α-Ketoglutaric Acid Principal 1 Small molecule 3.3 3.9 4.5 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT2B 5-HT2B Rat 5-Hydroxytryptamine Principal 1 Small molecule 7.9 8.2 8.4 Refs
A (Rhodopsin) Class A orphan LGR4 LGR4 Human R-Spondin-3 2 Peptide 10.7 10.7 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Rat Pge2 None 1 Small molecule 9.4 9.4 9.1 9.1 Refs
A (Rhodopsin) Class A orphan MRGRD MRGPRD Human Β-Alanine Principal 1 Small molecule 4.8 4.8 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Rat Vip 1 Peptide 7.9 9.0 10.0 8.5 9.2 9.8 Refs
A (Rhodopsin) Class A orphan GPR12 GPR12 Human Sphingosine 1-Phosphate Principal 1 Small molecule 5.5 6.3 7.0 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl7 4 Peptide Refs
A (Rhodopsin) Opioid OPRX NOP Mouse Nociceptin/Orphanin Fq Principal 1 Peptide 8.4 9.1 9.8 9.7 9.4 9.4 Refs
A (Rhodopsin) Chemokine CXCR6 CXCR6 Human Cxcl16 Principal 1 Peptide Refs
A (Rhodopsin) Galanin GALR1 GAL1 Human Galanin 2 Peptide 9.1 9.8 10.5 Refs
A (Rhodopsin) Somatostatin SSR1 SST1 Human Srif-14 2 Peptide 8.6 9.1 9.5 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl8 3 Peptide Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Mouse Pgf None 3 Small molecule 6.2 6.4 6.4 Refs
A (Rhodopsin) Leukotriene CLTR1 CysLT1 Human Lte4 None 3 Small molecule 6.4 6.7 7.2 7.1 7.5 7.8 Refs
A (Rhodopsin) Leukotriene CLTR2 CysLT2 Human Ltc4 None 1 Small molecule 7.0 7.6 8.6 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Human Kallidin 2 Peptide 7.0 8.0 8.9 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Rat Pgd2 None 3 Small molecule 7.9 7.9 5.9 7.4 8.9 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Human Pacap-38 2 Peptide 7.5 8.9 10.3 8.4 8.6 8.8 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Rat Vip 3 Peptide 7.3 8.3 9.3 7.8 8.4 8.8 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Mouse Srif-28 2 Peptide 8.1 9.1 9.1 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Rat Pgd2 None 5 Small molecule 4.7 4.7 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Mouse Pge2 None 2 Small molecule 7.5 7.9 8.3 Refs
A (Rhodopsin) Neurotensin NTR2 NTS2 Rat Neurotensin 1 Peptide 8.8 8.8 Refs
B1 (Secretin) Calcitonin CALCR CT Human Amylin 3 Peptide 8.0 8.6 9.2 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Mouse Pge2 None 1 Small molecule 9.4 9.4 9.1 9.1 Refs
A (Rhodopsin) P2Y P2Y11 P2Y11 Human Uridine Triphosphate None 1 Small molecule 5.2 5.2 Refs
A (Rhodopsin) Bombesin GRPR BB2 Human Gastrin-Releasing Peptide 1 Peptide 6.3 7.3 8.2 Refs
A (Rhodopsin) Bombesin GRPR BB2 Mouse Neuromedin B 2 Peptide 6.6 7.0 7.4 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Pacap-27 2 Peptide 7.6 8.5 9.4 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR3 LPA3 Human Farnesyl Diphosphate None 2 Small molecule Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl2 1 Peptide Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Human Srif-14 3 Peptide 8.4 9.2 9.9 Refs
A (Rhodopsin) P2Y P2RY4 P2Y4 Human Uridine Triphosphate None 1 Small molecule 6.3 6.3 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT7R 5-HT7 Human 5-Hydroxytryptamine Principal 1 Small molecule 8.7 9.0 9.2 Refs
A (Rhodopsin) Free fatty acid FFAR4 FFA4 Rat Α-Linolenic Acid None 2 Small molecule 5.5 5.5 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Rat Pge2 None 3 Small molecule 6.1 6.1 8.1 9.0 9.0 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Mouse Pgd2 None 2 Small molecule 7.4 7.5 7.5 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Rat Srif-28 1 Peptide 9.2 9.8 10.3 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT4R 5-HT4 Mouse 5-Hydroxytryptamine Principal 1 Small molecule 6.7 7.5 8.2 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT5A 5-HT5A Rat 5-Hydroxytryptamine Principal 1 Small molecule 6.7 6.8 6.9 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Des-Br-Neuropeptide B-23 4 Peptide Refs
A (Rhodopsin) Dopamine DRD3 D3 Human Dopamine Principal 1 Small molecule 6.4 6.9 7.3 Refs
C (Glutamate) Class C Orphan GPC6A GPRC6 Human Glycine None 4 Small molecule 3.6 3.6 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR4 S1P4 Human Sphingosine 1-Phosphate None 1 Small molecule 7.2 7.7 8.1 Refs
A (Rhodopsin) Class A orphan GP139 GPR139 Human L-Tryptophan None 1 Small molecule 3.7 3.7 3.1 3.1 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1F 5-HT1F Human 5-Hydroxytryptamine Principal 1 Small molecule 7.7 7.9 8.0 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl2 5 Peptide
A (Rhodopsin) Chemokine CCR8 CCR8 Human Ccl1 1 Peptide Refs
B1 (Secretin) Parathyroid hormone PTH1R PTH1 Human Pthrp-(1-36) 2 Peptide Refs
B1 (Secretin) Glucagon receptor family SCTR secretin Rat Vip 2 Peptide Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Neuropeptide Sf 3 Peptide
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Pge2 None 3 Small molecule 6.1 6.1 8.1 9.0 9.0 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Human Neuropeptide Y 4 Peptide 6.4 8.0 8.0 Refs
C (Glutamate) Metabotropic glutamate GRM6 mGlu6 Human L-Glutamic Acid None 2 Small molecule 4.8 5.0 5.2 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR4 LPA4 Human Farnesyl Diphosphate None 2 Small molecule Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Qrfp43 (43rfa) 3 Peptide
A (Rhodopsin) 5-Hydroxytryptamine 5HT1D 5-HT1D Human 5-Hydroxytryptamine None 1 Small molecule 8.0 8.5 9.0 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Vip 1 Peptide 7.9 9.0 10.0 8.5 9.2 9.8 Refs
A (Rhodopsin) Leukotriene CLTR1 CysLT1 Human Ltd4 None 1 Small molecule 7.3 8.6 9.4 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Human Octopamine None 4 Small molecule
A (Rhodopsin) Apelin APJ apelin Human Apelin-36 2 Peptide Refs
A (Rhodopsin) Cannabinoid CNR1 CB1 Human Anandamide None 2 Small molecule 6.3 6.7 7.0 Refs
C (Glutamate) Metabotropic glutamate GRM2 mGlu2 Human L-Glutamic Acid Principal 1 Small molecule 4.7 5.1 5.4 5.4 5.7 5.9