Data showed in this table is continously collected from the Guide to Pharmacology database. Ref

Receptor Endogenous ligands pEC50 pKi References
Class Receptor family UniProt IUPHAR Species Ligand GtP
Classification
Potency
Ranking
Type Min Mid Max Min Mid Max
A (Rhodopsin) Class A orphan GPR17 GPR17 Mouse Ltd4 None 3 Small molecule 8.1 8.3 8.4 Refs
A (Rhodopsin) Urotensin UR2R UT Human Urotensin-Ii 2 Peptide 8.2 8.6 9.0 Refs
A (Rhodopsin) Neurotensin NTR1 NTS1 Rat Neurotensin 1 Peptide 8.3 9.0 9.7 Refs
A (Rhodopsin) Opioid OPRD δ Human Dynorphin A-(1-13) 4 Peptide 7.8 7.8 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT4R 5-HT4 Rat 5-Hydroxytryptamine None Small molecule 6.7 7.5 8.2 Refs
A (Rhodopsin) Histamine HRH4 H4 Rat Histamine None 1 Small molecule 7.8 7.4 7.4 Refs
A (Rhodopsin) Chemerin CML1 hemerin Human 18r-Hepe 2 Small molecule
C (Glutamate) Metabotropic glutamate GRM4 mGlu4 Human L-Glutamic Acid None 2 Small molecule 4.7 5.1 5.5 4.9 5.2 5.5 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR1 S1P1 Mouse Sphingosine 1-Phosphate None 1 Small molecule 7.1 8.7 9.5 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR1 LPA1 Mouse Lpa None Small molecule 7.9 8.1 8.3 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Human Srif-14 4 Peptide 7.7 8.4 9.1 Refs
A (Rhodopsin) Opioid OPRK κ Mouse Α-Neoendorphin 3 Peptide 8.3 9.3 10.2 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Rat Pgf Secondary Small molecule 6.2 6.3 6.3 Refs
A (Rhodopsin) Neurotensin NTR2 NTS2 Rat Neurotensin 1 Peptide 8.8 8.8 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Rat Pgd2 Secondary Small molecule 8.8 8.8 8.7 5.9 5.9 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Human Pgf Secondary Small molecule 5.2 5.6 5.6 Refs
A (Rhodopsin) Melanocortin MC4R MC4 Human Α-Msh Secondary Peptide 7.4 7.7 8.0 Refs
A (Rhodopsin) Chemokine CCR7 CCR7 Mouse Ccl19 Peptide Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT7R 5-HT7 Human 5-Hydroxytryptamine None Small molecule 8.1 8.9 9.6 Refs
A (Rhodopsin) Neuromedin U NMUR1 NMU1 Human Neuromedin U-25 2 Peptide 8.4 8.9 9.4 9.5 9.5 Refs
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Tip39 Peptide
A (Rhodopsin) Opioid OPRK κ Human Α-Neoendorphin 3 Peptide 8.3 9.3 10.2 Refs
A (Rhodopsin) GPR18, GPR55 and GPR119 GP119 GPR119 Human N-Oleoylethanolamide None 1 Small molecule 5.4 5.9 6.3 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Rat Vip Principal Peptide 7.9 9.0 10.0 8.5 9.2 9.8 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Rat Pge1 Secondary Small molecule 9.5 9.5 8.7 8.7 Refs
A (Rhodopsin) Galanin GALR1 GAL1 Mouse Galanin 1 Peptide 9.8 9.8 9.3 9.8 10.3 Refs
A (Rhodopsin) Galanin GALR1 GAL1 Human Galanin 2 Peptide 9.2 9.6 9.9 Refs
A (Rhodopsin) Succinate SUCR1 succinate Human Succinic Acid None 2 Small molecule 3.1 3.9 4.7 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Neuropeptide Sf 3 Peptide
A (Rhodopsin) Trace amine TAAR1 TA1 Rat Tyramine None 2 Small molecule 6.2 6.7 7.1 6.4 6.4 Refs
A (Rhodopsin) Peptide P518 QRFPR QRFP Human Qrfp26 (26rfa) 2 Peptide 8.1 8.1 Refs
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl11 Peptide
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Vip Principal Peptide 7.9 9.0 10.0 8.5 9.2 9.8 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Rat Srif-28 3 Peptide 8.1 9.0 9.9 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Human Srif-28 2 Peptide 8.4 9.3 10.2 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl11 Principal Peptide 9.7 9.9 10.0 Refs
C (Glutamate) Calcium-sensing CASR CaS Rat Ca2+ None Small molecule Refs
A (Rhodopsin) Apelin APJ apelin Human [Pyr1]Apelin-13 Peptide Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Pgf Secondary Small molecule 6.2 6.3 6.3 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Mouse Cxcl8 2 Peptide 8.8 6.4 6.4 Refs
A (Rhodopsin) Vasopressin and oxytocin V2R V2 Human Vasopressin Principal Peptide 7.9 8.5 9.1 Refs
A (Rhodopsin) Hydroxycarboxylic acid HCAR2 HCA2 Human Butyric Acid None 2 Small molecule 2.8 2.8
A (Rhodopsin) Opioid OPRK κ Rat Β-Neoendorphin 4 Peptide 9.1 9.1 Refs
A (Rhodopsin) Somatostatin SSR1 SST1 Rat Srif-14 2 Peptide 8.6 9.1 9.5 Refs
A (Rhodopsin) Bombesin GRPR BB2 Rat Gastrin-Releasing Peptide 2 Peptide 6.3 7.3 8.2 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Mouse Srif-28 3 Peptide 8.1 9.0 9.9 Refs
A (Rhodopsin) Bombesin GRPR BB2 Human Gastrin-Releasing Peptide 2 Peptide 6.3 7.3 8.2 Refs
A (Rhodopsin) Prostanoid PF2R FP Human Pge2 Secondary Small molecule 6.4 7.0 7.0 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl7 Secondary Peptide 8.6 8.9 9.2 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Rat Pgd2 None 1 Small molecule 7.4 7.5 7.5 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Rat Urocortin 3 2 Peptide Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Human Kallidin 3 Peptide 7.0 8.0 8.9 Refs
A (Rhodopsin) Opioid OPRM μ Human Β-Endorphin 6 Peptide
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl1 1 Peptide 8.4 8.1 8.1 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl16 Secondary Peptide
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl4 8 Peptide
A (Rhodopsin) Tachykinin NK2R NK2 Human Substance P Secondary Peptide 5.9 6.4 6.9 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR5 LPA5 Human Lpa None 3 Small molecule 4.3 6.1 7.9 Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Cxcl11 9 Peptide
A (Rhodopsin) Somatostatin SSR4 SST4 Human Cortistatin-14 3 Peptide 8.6 8.7 8.8 Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Γ-Msh Secondary Peptide
A (Rhodopsin) 5-Hydroxytryptamine 5HT2B 5-HT2B Rat 5-Hydroxytryptamine None Small molecule 7.9 8.0 8.0 Refs
A (Rhodopsin) Peptide P518 QRFPR QRFP Mouse Qrfp43 4 Peptide 6.7 7.0 7.2 Refs
A (Rhodopsin) Adren ADRB3 β3-adren Human (&Plusmn;)-Adrenaline None 1 Small molecule 3.9 5.3 5.3 Refs
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C3a 2 Peptide
A (Rhodopsin) Opioid OPRK κ Mouse Dynorphin A 1 Peptide 10.0 10.2 10.3 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Human Uridine Diphosphate None 3 Small molecule 7.1 7.1 Refs
A (Rhodopsin) Urotensin UR2R UT Mouse Urotensin-Ii 2 Peptide 8.2 8.6 9.0 Refs
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl2 Peptide
A (Rhodopsin) Lysophospholipid (S1P) S1PR2 S1P2 Human Sphingosine 1-Phosphate None 1 Small molecule 8.1 8.3 8.5 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Rat [Des-Arg10]Kallidin 2 Peptide 8.7 8.8 8.8 Refs
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C5a 1 Peptide 8.0 8.5 9.0 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Rat Kallidin 3 Peptide 7.0 8.0 8.9 Refs
A (Rhodopsin) Galanin GALR1 GAL1 Rat Galanin 1 Peptide 9.8 9.8 9.3 9.8 10.3 Refs
A (Rhodopsin) Formylpeptide FPR3 FPR3 Human F2l 4 Peptide
A (Rhodopsin) Neuromedin U NMUR2 NMU2 Human Neuromedin S-33 1 Peptide 10.0 10.0 Refs
A (Rhodopsin) Free fatty acid FFAR4 FFA4 Rat Α-Linolenic Acid None 2 Small molecule 5.5 5.5 Refs
A (Rhodopsin) Bombesin NMBR BB1 Human Neuromedin B 1 Peptide 8.1 9.2 10.3 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide W-30 Peptide Refs
A (Rhodopsin) Adren ADA1B α1B-adren Human (-)-Adrenaline None 1 Small molecule 6.5 6.5 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR1 S1P1 Human Sphingosine 1-Phosphate None 1 Small molecule 7.1 8.7 9.5 Refs
C (Glutamate) Metabotropic glutamate GRM8 mGlu8 Human L-Serine-O-Phosphate None 2 Small molecule Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Prrp-31 2 Peptide
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Gastrin-17 Peptide
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Mouse Pancreatic Polypeptide Secondary Peptide 10.5 10.6 10.6 Refs
A (Rhodopsin) Chemokine ACKR4 ACKR4 Human Ccl25 3 Peptide 7.9 8.1 8.3 7.6 7.6 Refs
A (Rhodopsin) Somatostatin SSR4 SST4 Human Srif-14 2 Peptide 8.4 8.9 9.3 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Human Pacap-27 Principal Peptide 7.4 8.9 10.6 6.9 8.0 8.5 Refs
A (Rhodopsin) Histamine HRH1 H1 Human Histamine None Small molecule 4.7 5.3 5.9 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Mouse Pgj2 None 3 Small molecule 7.3 7.3 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Rat Pacap-27 Principal Peptide 7.4 8.9 10.6 6.9 8.0 8.5 Refs
A (Rhodopsin) Vasopressin and oxytocin V1BR V1B Rat Vasopressin Principal Peptide 9.0 9.9 9.9 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR5 S1P5 Human Sphingosine 1-Phosphate None 1 Small molecule 7.4 8.2 8.9 Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Mouse Humanin 6 Peptide 6.0 6.5 7.0 Refs
A (Rhodopsin) Melatonin MTR1B MT2 Human Melatonin None Small molecule 9.4 9.6 9.8 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT7R 5-HT7 Mouse 5-Hydroxytryptamine None Small molecule 8.1 8.9 9.6 Refs
A (Rhodopsin) Proteinase-activated PAR3 PAR3 Human Thrombin Peptide
A (Rhodopsin) GPR18, GPR55 and GPR119 GPR55 GPR55 Human 2-Arachidonoylglycerolphosphoinositol None 5 Small molecule Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Human Udp-Glucose None 4 Small molecule 5.9 7.7 9.5 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Rat Pge2 Principal Small molecule 9.4 9.4 9.0 9.0 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR2 LPA2 Human Lpa None 1 Small molecule 8.0 8.1 8.2 Refs
A (Rhodopsin) Neuropeptide S NPSR1 NPS Human Neuropeptide S Peptide 8.5 8.5 Refs
A (Rhodopsin) Free fatty acid FFAR2 FFA2 Human Butyric Acid None 4 Small molecule 2.9 3.8 4.6 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Rat Uridine Diphosphate None 3 Small molecule 7.1 7.1 Refs
A (Rhodopsin) Class A orphan LGR6 LGR6 Human R-Spondin-4 Peptide Refs
A (Rhodopsin) Opioid OPRK κ Rat Dynorphin A-(1-13) 2 Peptide 9.3 10.0 10.7 Refs
A (Rhodopsin) Class A orphan LGR5 LGR5 Human R-Spondin-3 3 Peptide 11.0 11.0 Refs
A (Rhodopsin) Complement peptide C5AR2 C5a2 Human C5a 1 Peptide 8.9 8.9 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl23 Principal Peptide 8.9 8.9 Refs
A (Rhodopsin) Melanocortin MSHR MC1 Mouse Agouti Secondary Peptide Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Human Udp N-Acetyl-Glucosamine None 5 Small molecule 6.0 6.0 Refs
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C3a 2 Peptide
A (Rhodopsin) Prostanoid PE2R3 EP3 Rat Pge1 Secondary Small molecule 9.4 9.4 9.0 9.0 Refs
A (Rhodopsin) Leukotriene LT4R2 BLT2 Human 12-Hydroxyheptadecatrienoic Acid None 1 Small molecule 7.7 7.7 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Mouse Pge2 Principal Small molecule 6.1 6.1 8.5 9.0 9.0 Refs
A (Rhodopsin) Adenosine AA3R A3 Rat Adenosine None Small molecule 6.5 6.5 Refs
A (Rhodopsin) Galanin GALR1 GAL1 Human Galanin-Like Peptide 2 Peptide
A (Rhodopsin) Trace amine TAAR1 TA1 Rat Β-Phenylethylamine None 3 Small molecule 6.4 6.5 6.6 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Human Vasopressin Principal Peptide 8.5 8.4 8.4 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Mouse Urocortin 2 2 Peptide Refs
A (Rhodopsin) Chemerin CML1 hemerin Human Chemerin 1 Peptide 7.6 8.0 8.5 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl7 Secondary Peptide
A (Rhodopsin) Galanin GALR2 GAL2 Rat Galanin 2 Peptide 8.3 8.3 8.3 8.8 9.3 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Mouse Cortistatin-14 2 Peptide 8.7 9.1 9.4 Refs
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C5a Des-Arg 2 Peptide Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Mouse Pge2 Principal Small molecule 7.3 7.7 8.0 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Human Pacap-38 Principal Peptide 9.5 9.8 10.0 6.9 8.2 9.0 Refs
A (Rhodopsin) Somatostatin SSR4 SST4 Rat Srif-14 2 Peptide 8.4 8.9 9.3 Refs
A (Rhodopsin) Melanocortin MC3R MC3 Human Γ-Msh Principal Peptide Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Human Srif-28 3 Peptide 8.1 9.0 9.9 Refs
A (Rhodopsin) Dopamine DRD3 D3 Human Dopamine None Small molecule 6.4 6.9 7.3 Refs
A (Rhodopsin) Class A orphan TAAR3 TAAR3 Mouse Isoamylamine None Small molecule 5.0 5.0 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Neuropeptide Af 2 Peptide
A (Rhodopsin) Prostanoid PE2R3 EP3 Mouse Pge2 Principal Small molecule 9.4 9.4 9.0 9.0 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Pge2 Principal Small molecule 6.1 6.1 8.5 9.0 9.0 Refs
C (Glutamate) Metabotropic glutamate GRM5 mGlu5 Rat L-Glutamic Acid None Small molecule 5.0 5.3 5.5 Refs
A (Rhodopsin) Adenosine AA3R A3 Human Adenosine None Small molecule 6.5 6.5 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Cck-8 Peptide Refs
A (Rhodopsin) Leukotriene CLTR2 CysLT2 Human Ltd4 None 2 Small molecule 6.8 7.6 8.6 7.3 7.7 8.1 Refs
A (Rhodopsin) Ghrelin GHSR ghrelin Human Ghrelin 1 Peptide 7.2 8.1 9.5 7.8 8.0 8.1 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Mouse [Des-Arg10]Kallidin 2 Peptide 8.7 8.8 8.8 Refs
A (Rhodopsin) Chemokine CX3C1 CX3CR1 Human Cx3Cl1 Peptide
A (Rhodopsin) Bombesin GRPR BB2 Mouse Neuromedin B 3 Peptide 6.6 7.0 7.4 Refs
A (Rhodopsin) Leukotriene CLTR1 CysLT1 Human Ltd4 None 1 Small molecule 7.3 8.6 9.4 Refs
A (Rhodopsin) Chemokine CCR7 CCR7 Human Ccl21b Peptide Refs
A (Rhodopsin) Vasopressin and oxytocin OXYR OT Human Oxytocin Principal Peptide 8.2 8.7 8.7 Refs
A (Rhodopsin) Prokineticin PKR2 PKR2 Human Prokineticin-1 Peptide Refs
A (Rhodopsin) Bombesin GRPR BB2 Rat Neuromedin B 3 Peptide 6.6 7.0 7.4 Refs
A (Rhodopsin) Opioid OPRK κ Rat Β-Endorphin 7 Peptide 6.3 6.8 6.8 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT4R 5-HT4 Mouse 5-Hydroxytryptamine None Small molecule 6.7 7.5 8.2 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl3 5 Peptide 8.0 8.5 8.9 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Rat Pge2 Principal Small molecule 7.5 7.9 8.3 Refs
A (Rhodopsin) P2Y P2RY4 P2Y4 Human Atp None 2 Small molecule 5.7 5.4 5.4 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Vip Principal Peptide 7.3 8.3 9.3 7.8 8.4 8.8 Refs
A (Rhodopsin) Adren ADRB1 β1-adren Human (-)-Noradrenaline None 2 Small molecule 5.5 5.8 6.0 Refs
F (Frizzled) Frizzled FZD6 FZD6 Human Wnt-3a Peptide Refs
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Rat Pancreatic Polypeptide Secondary Peptide 8.4 8.9 9.3 Refs
A (Rhodopsin) Proteinase-activated PAR3 PAR3 Human Thrombin Peptide
A (Rhodopsin) Trace amine TAAR1 TA1 Mouse 3-Iodothyronamine None 1 Small molecule 6.5 6.8 7.0 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Human [Des-Arg9]Bradykinin 1 Peptide 5.7 9.2 9.2 Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Acth Secondary Peptide
A (Rhodopsin) Chemokine CCR8 CCR8 Human Ccl1 Principal Peptide Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Rat Pge2 Principal Small molecule 6.1 6.1 8.5 9.0 9.0 Refs
A (Rhodopsin) Orexin OX2R OX2 Human Orexin-A 1 Peptide 6.5 8.3 10.0 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Rat Vasopressin Principal Peptide 8.5 8.4 8.4 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Human Oxytocin Secondary Peptide 6.9 7.6 8.3 Refs
A (Rhodopsin) Histamine HRH3 H3 Mouse Histamine None Small molecule 7.2 7.6 7.9 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1D 5-HT1D Human 5-Hydroxytryptamine None 1 Small molecule 8.0 8.5 9.0 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Human Srif-14 1 Peptide 9.0 9.1 9.1 8.9 9.7 10.5 Refs
A (Rhodopsin) Kisspeptin KISSR kisspeptin Human Kisspeptin-54 2 Peptide 8.8 9.2 9.5 Refs
A (Rhodopsin) Vasopressin and oxytocin OXYR OT Human Vasopressin Secondary Peptide 7.3 8.3 9.3 Refs
A (Rhodopsin) Melanocortin MSHR MC1 Human Acth Secondary Peptide
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Cck-33 Peptide Refs
A (Rhodopsin) Gonadotrophin-releasing hormone GNRHR GnRH1 Mouse Gnrh I 1 Peptide 7.8 7.9 7.9 7.3 8.0 8.4 Refs
A (Rhodopsin) Adren ADA2B α2B-adren Human (-)-Noradrenaline None 1 Small molecule 5.4 5.7 6.0 Refs
A (Rhodopsin) Tachykinin NK2R NK2 Human Neurokinin A Principal Peptide 8.9 8.9 8.0 8.6 9.1 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl26 Secondary Peptide Refs
A (Rhodopsin) Angiotensin AGTR1 AT1 Human Angiotensin A 1 Peptide 8.2 8.2 8.8 8.8 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR1 S1P1 Human Sphingosylphosphorylcholine 2 Small molecule
A (Rhodopsin) Peptide P518 QRFPR QRFP Rat Qrfp43 (43rfa) 3 Peptide 6.9 7.8 8.6 Refs
A (Rhodopsin) Hydroxycarboxylic acid HCAR2 HCA2 Human Β-D-Hydroxybutyric Acid None 1 Small molecule 3.5 3.5 Refs
A (Rhodopsin) Class A orphan GPR32 GPR32 Human Resolvin D1 None 1 Small molecule 11.1 11.1 Refs
A (Rhodopsin) P2Y P2RY1 P2Y1 Human Adp None 2 Small molecule Refs
A (Rhodopsin) Vasopressin and oxytocin V2R V2 Human Oxytocin Secondary Peptide 5.4 6.1 6.8 Refs
A (Rhodopsin) Orexin OX1R OX1 Human Orexin-A 1 Peptide 6.5 8.4 10.2 Refs
A (Rhodopsin) Adren ADA1A α1A-adren Human (-)-Noradrenaline None 2 Small molecule 5.8 6.1 6.4 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Phi Secondary Peptide
A (Rhodopsin) P2Y P2Y14 P2Y14 Mouse Udp-Glucuronic Acid None 2 Small molecule 7.2 7.2 Refs
A (Rhodopsin) Peptide P518 QRFPR QRFP Mouse Qrfp26 1 Peptide 8.2 8.2 Refs
A (Rhodopsin) Bombesin GRPR BB2 Mouse Gastrin-Releasing Peptide 2 Peptide 6.3 7.3 8.2 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Rat Pgd2 Secondary Small molecule 5.3 5.3 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Human Pgd2 Secondary Small molecule 5.3 5.3 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl2 Principal Peptide
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Rat Cck-33 Peptide Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Human Urocortin 1 2 Peptide Refs
A (Rhodopsin) Prostanoid PF2R FP Human Pgi2 Secondary Small molecule
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Gastrin-34 Peptide
A (Rhodopsin) Somatostatin SSR5 SST5 Human Cst-17 1 Peptide 8.8 9.3 9.8 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Rat Galanin 2 Peptide 8.1 8.5 8.8 Refs
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM3 M3 Human Acetylcholine None Small molecule 4.5 5.0 5.4 Refs
A (Rhodopsin) Vasopressin and oxytocin OXYR OT Rat Oxytocin Principal Peptide 8.2 8.7 8.7 Refs
A (Rhodopsin) Neuromedin U NMUR1 NMU1 Human Neuromedin S-36 3 Peptide
A (Rhodopsin) Apelin APJ apelin Human Apelin Receptor Early Endogenous Ligand Peptide
A (Rhodopsin) Bradykinin BKRB1 B1 Mouse [Des-Arg9]Bradykinin 1 Peptide 5.7 9.2 9.2 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Human Pge2 Principal Small molecule 9.4 9.4 9.0 9.0 Refs
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM4 M4 Human Acetylcholine None Small molecule 4.5 5.1 5.6 Refs
A (Rhodopsin) Histamine HRH3 H3 Human Histamine None Small molecule 7.2 7.6 7.9 Refs
A (Rhodopsin) Opioid OPRK κ Human Dynorphin A-(1-8) 6 Peptide 8.0 9.0 9.9 Refs
A (Rhodopsin) Kisspeptin KISSR kisspeptin Human Kisspeptin-52 5 Peptide
A (Rhodopsin) Neurotensin NTR2 NTS2 Rat Neuromedin N 2 Peptide Refs
B1 (Secretin) Calcitonin CALCR CT Human Calcitonin Principal Peptide 9.0 10.1 11.2 Refs
A (Rhodopsin) Free fatty acid FFAR2 FFA2 Human Acetic Acid None 2 Small molecule 3.1 3.9 4.6 Refs
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Pth Peptide
A (Rhodopsin) P2Y P2Y14 P2Y14 Human Udp-Glucose None 1 Small molecule 7.7 7.7 Refs
A (Rhodopsin) Adren ADRB2 β2-adren Human Zn2+ None 4 Small molecule 3.3 4.3 5.3 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Rat Srif-14 4 Peptide 7.7 8.4 9.1 Refs
B1 (Secretin) Glucagon receptor family GLP2R GLP-2 Rat Glucagon-Like Peptide 2 2 Peptide 8.8 8.8 Refs
A (Rhodopsin) Leukotriene OXER1 OXE Human 5-Oxo-C20:3 None 2 Small molecule 8.0 8.0 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR2 LPA2 Mouse Lpa None 1 Small molecule 8.0 8.1 8.2 Refs
A (Rhodopsin) Opioid OPRX NOP Mouse Nociceptin/Orphanin Fq Peptide 8.4 9.1 9.8 9.7 9.4 9.4 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Mouse Pancreatic Polypeptide Secondary Peptide 10.3 10.7 10.7 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Mouse Srif-14 4 Peptide 8.7 8.9 8.9 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Rat Oxytocin Secondary Peptide 6.9 7.6 8.3 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Mouse Srif-14 1 Peptide 9.0 9.1 9.1 8.9 9.7 10.5 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Human Srif-14 4 Peptide 8.7 8.9 8.9 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT2C 5-HT2C Human 5-Hydroxytryptamine None Small molecule 6.7 7.3 7.9 Refs
A (Rhodopsin) Apelin APJ apelin Human Apelin-13 Peptide Refs
A (Rhodopsin) Prostanoid TA2R TP Human Pgd2 Secondary Small molecule
A (Rhodopsin) Somatostatin SSR2 SST2 Rat Srif-28 2 Peptide 8.4 9.3 10.2 Refs
A (Rhodopsin) Tachykinin NK3R NK3 Mouse Neurokinin A 2 Peptide 7.4 7.4 5.5 6.1 6.1 Refs
A (Rhodopsin) Chemokine ACKR3 ACKR3 Human Cxcl12Α 1 Peptide 7.5 7.7 7.9 Refs
A (Rhodopsin) Orexin OX2R OX2 Human Orexin-B 1 Peptide 6.5 8.3 10.0 Refs
A (Rhodopsin) Adenosine AA2AR A2A Human Adenosine None