Data showed in this table is continously collected from the Guide to Pharmacology database. Ref
| RECEPTOR | ENDOGENOUS LIGANDS | pEC50 | pKi | REFERENCES | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Class | Receptor family | UniProt | IUPHAR | Species | Ligand | GtP Classification |
Potency Ranking |
Type | Min | Mid | Max | Min | Mid | Max | |
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1F | 5-HT1F | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 7.7 | 7.9 | 8.0 | Refs | |||
| A (Rhodopsin) | Chemokine | CCR10 | CCR10 | Human | Ccl27 | Peptide | |||||||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT2C | 5-HT2C | Rat | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.8 | 7.7 | 8.6 | Refs | |||
| A (Rhodopsin) | Free fatty acid | FFAR3 | FFA3 | Human | Butyric Acid | None | 2 | Small molecule | 3.8 | 4.4 | 4.9 | Refs | |||
| A (Rhodopsin) | Somatostatin | SSR1 | SST1 | Human | Srif-14 | 2 | Peptide | 8.6 | 9.1 | 9.5 | Refs | ||||
| A (Rhodopsin) | Adren | ADRB3 | β3-adren | Human | (-)-Noradrenaline | None | 2 | Small molecule | 4.7 | 4.2 | 4.2 | Refs | |||
| A (Rhodopsin) | Leukotriene | OXER1 | OXE | Human | 5-Oxo-20-Hete | None | 6 | Small molecule | 6.5 | 6.5 | Refs | ||||
| B1 (Secretin) | Glucagon receptor family | GHRHR | GHRH | Human | Ghrh | Principal | 1 | Peptide | |||||||
| A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Mouse | Srif-28 | 1 | Peptide | 9.2 | 9.8 | 10.3 | Refs | ||||
| B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Rat | Corticotrophin-Releasing Hormone | 1 | Peptide | 7.8 | 7.8 | Refs | |||||
| A (Rhodopsin) | Prostanoid | PF2R | FP | Human | Pgf2Α | None | 1 | Small molecule | 7.9 | 8.5 | 8.5 | Refs | |||
| A (Rhodopsin) | Lysophospholipid (S1P) | S1PR5 | S1P5 | Rat | Sphingosine 1-Phosphate | None | 1 | Small molecule | 7.4 | 8.2 | 8.9 | Refs | |||
| A (Rhodopsin) | P2Y | P2RY4 | P2Y4 | Human | Atp | None | 2 | Small molecule | 5.7 | 5.4 | 5.4 | Refs | |||
| A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Human | Thromboxane A2 | 6 | Small molecule | ||||||||
| A (Rhodopsin) | Histamine | HRH4 | H4 | Mouse | Histamine | None | 1 | Small molecule | 7.8 | 8.1 | 8.3 | Refs | |||
| A (Rhodopsin) | Prostanoid | PD2R | DP1 | Rat | Pgd2 | None | 2 | Small molecule | 7.8 | 7.7 | 7.7 | Refs | |||
| A (Rhodopsin) | Chemokine | ACKR1 | ACKR1 | Human | Cxcl6 | Peptide | |||||||||
| A (Rhodopsin) | Proteinase-activated | PAR4 | PAR4 | Human | Cathepsin G | Peptide | |||||||||
| A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Mouse | Srif-28 | 2 | Peptide | 8.1 | 9.0 | 9.9 | Refs | ||||
| A (Rhodopsin) | Chemokine | CXCR3 | CXCR3 | Human | Cxcl10 | 2 | Peptide | 7.8 | 8.8 | 9.8 | Refs | ||||
| A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Rat | Pancreatic Polypeptide | 1 | Peptide | 10.3 | 10.6 | 10.8 | Refs | ||||
| A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Mouse | Srif-14 | 3 | Peptide | 8.7 | 8.9 | 8.9 | Refs | ||||
| A (Rhodopsin) | Prokineticin | PKR2 | PKR2 | Human | Prokineticin-2Β | 3 | Peptide | Refs | |||||||
| A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Rat | Srif-14 | 1 | Peptide | 9.0 | 9.1 | 9.1 | 8.8 | 9.2 | 9.6 | Refs | |
| A (Rhodopsin) | Opioid | OPRM | μ | Human | [Leu]Enkephalin | 5 | Peptide | 8.1 | 8.1 | Refs | |||||
| A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl28 | 5 | Peptide | ||||||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT2A | 5-HT2A | Rat | 5-Hydroxytryptamine | None | 2 | Small molecule | 6.0 | 6.3 | 6.5 | Refs | |||
| B1 (Secretin) | Calcitonin | CALCR | CT | Human | Adrenomedullin | 5 | Peptide | 6.7 | 7.2 | 7.7 | Refs | ||||
| A (Rhodopsin) | Chemokine | CXCR4 | CXCR4 | Human | Cxcl12Β | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Rat | Pgd2 | None | 2 | Small molecule | 8.8 | 8.8 | 8.7 | 5.9 | 5.9 | Refs | |
| A (Rhodopsin) | Galanin | GALR2 | GAL2 | Human | Galanin-Like Peptide | 4 | Peptide | ||||||||
| A (Rhodopsin) | Chemokine | CXCR3 | CXCR3 | Human | Cxcl12Α | 7 | Peptide | 6.4 | 6.4 | Refs | |||||
| A (Rhodopsin) | Bombesin | GRPR | BB2 | Human | Neuromedin B | 1 | Peptide | 6.4 | 7.3 | 8.1 | Refs | ||||
| A (Rhodopsin) | Neuropeptide Y | NPY2R | Y2 | Human | Pancreatic Polypeptide | 5 | Peptide | ||||||||
| A (Rhodopsin) | Bombesin | NMBR | BB1 | Human | Grp-(18-27) | 2 | Peptide | ||||||||
| A (Rhodopsin) | Histamine | HRH3 | H3 | Rat | Histamine | Principal | 1 | Small molecule | 7.1 | 7.5 | 7.8 | Refs | |||
| A (Rhodopsin) | Galanin | GALR2 | GAL2 | Mouse | Galanin | 2 | Peptide | 8.3 | 8.3 | 8.3 | 8.8 | 9.3 | Refs | ||
| A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Human | Pge2 | None | 1 | Small molecule | 7.3 | 7.7 | 7.7 | Refs | |||
| A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Rat | Pgf2Α | None | 3 | Small molecule | 6.1 | 6.1 | 9.1 | 9.3 | 9.5 | Refs | |
| A (Rhodopsin) | Vasopressin and oxytocin | V1BR | V1B | Rat | Vasopressin | 1 | Peptide | 9.0 | 9.9 | 9.9 | Refs | ||||
| A (Rhodopsin) | Chemerin | CML1 | hemerin | Human | 18r-Hepe | 2 | Small molecule | ||||||||
| A (Rhodopsin) | Lysophospholipid (LPA) | LPAR6 | LPA6 | Mouse | Lpa | Principal | 1 | Small molecule | 6.0 | 6.0 | Refs | ||||
| A (Rhodopsin) | Orexin | OX1R | OX1 | Human | Orexin-A | 1 | Peptide | 6.5 | 8.4 | 10.2 | Refs | ||||
| A (Rhodopsin) | Opioid | OPRD | δ | Human | Β-Endorphin | 7 | Peptide | ||||||||
| A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Human | Pge2 | None | 1 | Small molecule | 9.4 | 9.4 | 9.0 | 9.0 | Refs | ||
| A (Rhodopsin) | Tachykinin | NK2R | NK2 | Human | Neurokinin B | 3 | Peptide | 5.0 | 6.4 | 7.7 | Refs | ||||
| C (Glutamate) | Metabotropic glutamate | GRM6 | mGlu6 | Human | L-Glutamic Acid | None | 2 | Small molecule | 4.8 | 5.0 | 5.2 | Refs | |||
| A (Rhodopsin) | Lysophospholipid (S1P) | S1PR1 | S1P1 | Human | Sphingosine 1-Phosphate | None | 1 | Small molecule | 7.1 | 8.7 | 9.5 | Refs | |||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1E | 5-HT1E | Human | 5-Hydroxytryptamine | None | 1 | Small molecule | 8.0 | 8.1 | 8.2 | Refs | |||
| A (Rhodopsin) | Neuromedin U | NMUR2 | NMU2 | Human | Neuromedin U-25 | 2 | Peptide | 8.4 | 8.9 | 9.4 | 9.6 | 9.6 | Refs | ||
| B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Human | Vip | 3 | Peptide | 7.3 | 8.3 | 9.3 | 7.8 | 8.4 | 8.8 | Refs | |
| A (Rhodopsin) | Proteinase-activated | PAR1 | PAR1 | Human | Thrombin | Principal | 1 | Peptide | |||||||
| A (Rhodopsin) | Gonadotrophin-releasing hormone | GNRHR | GnRH1 | Human | Gnrh I | 1 | Peptide | 7.8 | 7.9 | 7.9 | 7.3 | 8.0 | 8.4 | Refs | |
| A (Rhodopsin) | Chemokine | XCR1 | XCR1 | Human | Xcl1 | 2 | Peptide | ||||||||
| A (Rhodopsin) | Adren | ADA2B | α2B-adren | Human | (-)-Adrenaline | None | 2 | Small molecule | 5.2 | 5.2 | Refs | ||||
| A (Rhodopsin) | Somatostatin | SSR4 | SST4 | Human | Srif-28 | 3 | Peptide | 8.1 | 8.7 | 9.2 | Refs | ||||
| B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Human | Phi | 4 | Peptide | ||||||||
| F (Frizzled) | Frizzled | FZD1 | FZD1 | Human | Wnt-1 | Peptide | |||||||||
| A (Rhodopsin) | Dopamine | DRD2 | D2 | Rat | Dopamine | Principal | 1 | Small molecule | 5.3 | 5.9 | 6.4 | Refs | |||
| A (Rhodopsin) | Leukotriene | CLTR2 | CysLT2 | Human | Lte4 | None | 3 | Small molecule | 5.6 | 6.3 | 7.1 | 6.5 | 6.5 | Refs | |
| A (Rhodopsin) | Prostanoid | PF2R | FP | Mouse | Pgf2Α | None | 1 | Small molecule | 7.9 | 8.5 | 8.5 | Refs | |||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1F | 5-HT1F | Rat | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 7.7 | 7.9 | 8.0 | Refs | |||
| A (Rhodopsin) | Prolactin-releasing peptide | PRLHR | PrRP | Human | Prrp-20 | 4 | Peptide | ||||||||
| A (Rhodopsin) | Tachykinin | NK1R | NK1 | Human | Neurokinin A | 2 | Peptide | 6.2 | 7.8 | 9.3 | Refs | ||||
| C (Glutamate) | Metabotropic glutamate | GRM4 | mGlu4 | Rat | L-Glutamic Acid | None | 2 | Small molecule | 4.7 | 5.1 | 5.5 | 4.9 | 5.2 | 5.5 | Refs |
| A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl26 | 5 | Peptide | Refs | |||||||
| A (Rhodopsin) | Galanin | GALR1 | GAL1 | Mouse | Galanin | 1 | Peptide | 9.8 | 9.8 | 9.0 | 9.6 | 10.1 | Refs | ||
| A (Rhodopsin) | Class A orphan | GPR35 | GPR35 | Mouse | Kynurenic Acid | None | 2 | Small molecule | 3.9 | 5.0 | 5.0 | Refs | |||
| A (Rhodopsin) | Lysophospholipid (LPA) | LPAR4 | LPA4 | Mouse | Lpa | None | 1 | Small molecule | Refs | ||||||
| A (Rhodopsin) | Prolactin-releasing peptide | PRLHR | PrRP | Human | Pthrp | 4 | Peptide | ||||||||
| A (Rhodopsin) | Opioid | OPRM | μ | Human | Dynorphin B | 2 | Peptide | 8.5 | 8.5 | Refs | |||||
| A (Rhodopsin) | Class A orphan | LGR5 | LGR5 | Human | R-Spondin-4 | 4 | Peptide | 9.4 | 9.4 | Refs | |||||
| B1 (Secretin) | Glucagon receptor family | GLP1R | GLP-1 | Human | Glucagon | 2 | Peptide | 6.9 | 7.0 | 7.0 | Refs | ||||
| A (Rhodopsin) | Adenosine | AA3R | A3 | Human | Adenosine | Principal | 1 | Small molecule | 5.2 | 5.2 | Refs | ||||
| A (Rhodopsin) | Relaxin family peptide | RL3R2 | RXFP4 | Human | Insl5 | 3 | Peptide | 7.0 | 7.7 | 8.9 | 7.3 | 8.1 | 8.8 | Refs | |
| B1 (Secretin) | Glucagon receptor family | GIPR | GIP | Human | Gastric Inhibitory Polypeptide | Principal | 1 | Peptide | |||||||
| A (Rhodopsin) | Lysophospholipid (LPA) | LPAR5 | LPA5 | Human | Farnesyl Monophosphate | None | 1 | Small molecule | 7.3 | 7.3 | Refs | ||||
| A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Rat | Pyy-(3-36) | 6 | Peptide | 6.2 | 6.2 | Refs | |||||
| A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl2 | 8 | Peptide | ||||||||
| B2 (Adhesion) | ADGRB | AGRB1 | ADGRB1 | Human | Phosphatidylserine | Principal | 1 | Small molecule | Refs | ||||||
| A (Rhodopsin) | Chemokine | CCR7 | CCR7 | Human | Ccl19 | 1 | Peptide | Refs | |||||||
| A (Rhodopsin) | Opioid | OPRK | κ | Human | Dynorphin A-(1-8) | 5 | Peptide | 8.0 | 9.0 | 9.9 | Refs | ||||
| A (Rhodopsin) | Leukotriene | CLTR1 | CysLT1 | Human | Ltc4 | None | 2 | Small molecule | 7.4 | 7.6 | 7.7 | 7.0 | 7.6 | 8.1 | Refs |
| A (Rhodopsin) | Lysophospholipid (S1P) | S1PR5 | S1P5 | Mouse | Sphingosine 1-Phosphate | None | 1 | Small molecule | 7.4 | 8.2 | 8.9 | Refs | |||
| A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Rat | Srif-14 | 3 | Peptide | 8.4 | 9.2 | 9.9 | Refs | ||||
| A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Rat | Udp-Glucose | None | 1 | Small molecule | 7.6 | 7.6 | Refs | ||||
| A (Rhodopsin) | Acetylcholine receptors (muscarinic) | ACM1 | M1 | Human | Acetylcholine | Principal | 1 | Small molecule | 4.3 | 5.0 | 5.0 | Refs | |||
| B1 (Secretin) | Glucagon receptor family | SCTR | secretin | Rat | Secretin | 2 | Peptide | 8.0 | 8.5 | 9.0 | Refs | ||||
| A (Rhodopsin) | Adren | ADRB2 | β2-adren | Human | Noradrenaline | None | 2 | Small molecule | 5.4 | 5.4 | Refs | ||||
| B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Human | Ghrh | 4 | Peptide | ||||||||
| B1 (Secretin) | Parathyroid hormone | PTH2R | PTH2 | Human | Pthrp | 5 | Peptide | ||||||||
| A (Rhodopsin) | Opioid | OPRK | κ | Rat | Dynorphin A-(1-13) | 1 | Peptide | 9.3 | 10.0 | 10.7 | Refs | ||||
| A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Rat | Tyramine | None | 3 | Small molecule | 6.2 | 6.7 | 7.1 | 6.4 | 6.4 | Refs | |
| A (Rhodopsin) | Adren | ADA2C | α2C-adren | Human | (-)-Adrenaline | None | 2 | Small molecule | 5.8 | 5.8 | Refs | ||||
| A (Rhodopsin) | Bradykinin | BKRB2 | B2 | Human | Lys-[Hyp3]-Bradykinin | 4 | Peptide | ||||||||
| A (Rhodopsin) | Adren | ADA1D | α1D-adren | Human | (-)-Adrenaline | None | 1 | Small molecule | 7.2 | 7.2 | Refs | ||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT4R | 5-HT4 | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 5.9 | 6.5 | 7.0 | Refs | |||
| A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Human | Pge1 | None | 1 | Small molecule | 8.0 | 8.0 | Refs | ||||
| A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Annexin I | 9 | Peptide | Refs | |||||||
| A (Rhodopsin) | Chemokine | CCR4 | CCR4 | Human | Ccl22 | 1 | Peptide | Refs | |||||||
| A (Rhodopsin) | Free fatty acid | FFAR2 | FFA2 | Human | Acetic Acid | None | 2 | Small molecule | 3.1 | 3.9 | 4.6 | Refs | |||
| A (Rhodopsin) | Endothelin | EDNRB | ETB | Human | Endothelin-2 | 2 | Peptide | ||||||||
| A (Rhodopsin) | Histamine | HRH3 | H3 | Human | Histamine | Principal | 1 | Small molecule | 7.1 | 7.5 | 7.8 | Refs | |||
| A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Mouse | Pge1 | None | 1 | Small molecule | 9.5 | 9.5 | 8.7 | 8.7 | Refs | ||
| A (Rhodopsin) | Vasopressin and oxytocin | V1BR | V1B | Human | Vasopressin | 1 | Peptide | 9.0 | 9.9 | 9.9 | Refs | ||||
| A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl3 | 5 | Peptide | 8.0 | 8.5 | 8.9 | Refs | ||||
| A (Rhodopsin) | Bradykinin | BKRB2 | B2 | Human | Bradykinin | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Rat | Srif-14 | 3 | Peptide | 8.7 | 8.9 | 8.9 | Refs | ||||
| A (Rhodopsin) | Endothelin | EDNRA | ETA | Human | Endothelin-3 | 3 | Peptide | ||||||||
| A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Human | Srif-14 | 3 | Peptide | 8.7 | 8.9 | 8.9 | Refs | ||||
| A (Rhodopsin) | Melatonin | MTR1B | MT2 | Human | Melatonin | Principal | 1 | Small molecule | 9.4 | 9.6 | 9.8 | Refs | |||
| A (Rhodopsin) | Galanin | GALR3 | GAL3 | Rat | Galanin | 2 | Peptide | 8.1 | 8.5 | 8.8 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PD2R | DP1 | Human | Pgj2 | None | 1 | Small molecule | 9.0 | 9.0 | Refs | ||||
| A (Rhodopsin) | Free fatty acid | FFAR4 | FFA4 | Human | Α-Linolenic Acid | None | 3 | Small molecule | 5.1 | 5.1 | Refs | ||||
| A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF2 | NPFF2 | Human | Rfrp-3 | 2 | Peptide | 7.8 | 7.8 | Refs | |||||
| A (Rhodopsin) | Opioid | OPRK | κ | Mouse | Dynorphin A | 2 | Peptide | 8.3 | 9.6 | 10.8 | Refs | ||||
| A (Rhodopsin) | Orexin | OX1R | OX1 | Human | Orexin-B | 3 | Peptide | ||||||||
| A (Rhodopsin) | Neurotensin | NTR1 | NTS1 | Rat | Neurotensin | 1 | Peptide | 8.3 | 9.0 | 9.7 | Refs | ||||
| B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Human | Secretin | 4 | Peptide | ||||||||
| A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF1 | NPFF1 | Human | Neuropeptide Ff | 2 | Peptide | 8.5 | 9.2 | 9.9 | Refs | ||||
| A (Rhodopsin) | Lysophospholipid (LPA) | LPAR3 | LPA3 | Mouse | Lpa | None | 1 | Small molecule | 6.6 | 6.6 | Refs | ||||
| A (Rhodopsin) | Chemokine | CXCR2 | CXCR2 | Human | Cxcl5 | 3 | Peptide | ||||||||
| A (Rhodopsin) | Lysophospholipid (S1P) | S1PR3 | S1P3 | Mouse | Sphingosine 1-Phosphate | None | 1 | Small molecule | 8.4 | 9.1 | 9.8 | Refs | |||
| A (Rhodopsin) | Neuromedin U | NMUR2 | NMU2 | Human | Neuromedin S-33 | 1 | Peptide | 10.0 | 10.0 | Refs | |||||
| A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Human | Pgf2Α | None | 3 | Small molecule | 5.2 | 5.6 | 6.0 | Refs | |||
| B1 (Secretin) | Parathyroid hormone | PTH2R | PTH2 | Human | Tip39 | 1 | Peptide | Refs | |||||||
| A (Rhodopsin) | Galanin | GALR1 | GAL1 | Rat | Galanin | 1 | Peptide | 9.8 | 9.8 | 9.0 | 9.6 | 10.1 | Refs | ||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1D | 5-HT1D | Human | 5-Hydroxytryptamine | None | 1 | Small molecule | 8.0 | 8.5 | 9.0 | Refs | |||
| A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl13 | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | Class A orphan | GPR37 | GPR37 | Human | Prosaptide | Principal | 1 | Peptide | 8.1 | 8.1 | Refs | ||||
| A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Human | Srif-14 | 3 | Peptide | 8.4 | 9.2 | 9.9 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Human | Pgj2 | None | 3 | Small molecule | 7.3 | 7.3 | Refs | ||||
| B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Human | Urocortin 1 | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | Melanocortin | MC5R | MC5 | Human | Agouti-Related Protein | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | Neuropeptide Y | Q9ERC0 | Y2 | Rat | Peptide Yy | 1 | Peptide | 10.0 | 10.0 | Refs | |||||
| A (Rhodopsin) | Formylpeptide | FPR1 | FPR1 | Human | Cathepsin G | 2 | Peptide | ||||||||
| A (Rhodopsin) | Melanin-concentrating hormon | MCHR1 | MCH1 | Human | Melanin-Concentrating Hormone | Principal | 1 | Peptide | 9.8 | 9.9 | 10.0 | Refs | |||
| A (Rhodopsin) | Opioid | OPRK | κ | Human | Β-Endorphin | 9 | Peptide | ||||||||
| A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Mouse | Udp-Glucose | None | 1 | Small molecule | 7.6 | 7.6 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Human | Pgf2Α | None | 3 | Small molecule | 6.2 | 6.4 | 6.4 | Refs | |||
| A (Rhodopsin) | Complement peptide | C5AR1 | C5a1 | Human | C3a | 2 | Peptide | ||||||||
| A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl8 | 5 | Peptide | ||||||||
| A (Rhodopsin) | Vasopressin and oxytocin | V1AR | V1A | Rat | Oxytocin | 2 | Peptide | 6.9 | 7.6 | 8.3 | Refs | ||||
| A (Rhodopsin) | Neuromedin U | NMUR1 | NMU1 | Human | Neuromedin U-23 | 3 | Peptide | ||||||||
| A (Rhodopsin) | Galanin | GALR1 | GAL1 | Human | Galanin | 2 | Peptide | 9.1 | 9.8 | 10.5 | Refs | ||||
| B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Rat | Vip | 3 | Peptide | 7.3 | 8.3 | 9.3 | 7.8 | 8.4 | 8.8 | Refs | |
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT4R | 5-HT4 | Mouse | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 5.9 | 6.5 | 7.0 | Refs | |||
| A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl3 | 1 | Peptide | 7.8 | 9.0 | 10.2 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Mouse | Pgd2 | None | 1 | Small molecule | 7.6 | 8.1 | 8.6 | Refs | |||
| A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Neuropeptide W-30 | 5 | Peptide | ||||||||
| A (Rhodopsin) | Class A orphan | GPR34 | GPR34 | Mouse | Lysophosphatidylserine | Principal | 1 | Small molecule | 6.6 | 7.3 | 7.3 | Refs | |||
| A (Rhodopsin) | Histamine | HRH1 | H1 | Human | Histamine | Principal | 1 | Small molecule | 4.7 | 5.3 | 5.9 | Refs | |||
| A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Humanin | 4 | Peptide | 8.5 | 8.5 | Refs | |||||
| A (Rhodopsin) | Somatostatin | SSR1 | SST1 | Human | Cortistatin-14 | 4 | Peptide | ||||||||
| A (Rhodopsin) | Adren | ADRB1 | β1-adren | Human | (-)-Adrenaline | None | 3 | Small molecule | 5.4 | 5.7 | 6.0 | Refs | |||
| B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Human | Secretin | 4 | Peptide | ||||||||
| A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Human | Cst-17 | 2 | Peptide | 8.8 | 9.1 | 9.3 | Refs | ||||
| B1 (Secretin) | Calcitonin | CALCR | CT | Human | Calcitonin | 1 | Peptide | 9.0 | 10.1 | 11.2 | Refs | ||||
| A (Rhodopsin) | Vasopressin and oxytocin | V2R | V2 | Human | Vasopressin | 1 | Peptide | 7.9 | 8.5 | 9.1 | Refs | ||||
| A (Rhodopsin) | Melanocortin | MC5R | MC5 | Human | Γ-Msh | 2 | Peptide | ||||||||
| A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Human | Peptide Yy | 5 | Peptide | 6.3 | 7.0 | 8.5 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Mouse | Pgd2 | None | 3 | Small molecule | 7.9 | 7.9 | 5.9 | 7.4 | 8.9 | Refs | |
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT5A | 5-HT5A | Rat | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.0 | 6.3 | 6.6 | Refs | |||
| A (Rhodopsin) | Somatostatin | SSR4 | SST4 | Human | Srif-14 | 2 | Peptide | 8.4 | 8.9 | 9.3 | Refs | ||||
| A (Rhodopsin) | Opioid | OPRK | κ | Rat | Dynorphin A | 2 | Peptide | 8.3 | 9.6 | 10.8 | Refs | ||||
| A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Human | Srif-28 | 2 | Peptide | 8.1 | 9.0 | 9.9 | Refs | ||||
| A (Rhodopsin) | Lysophospholipid (S1P) | S1PR3 | S1P3 | Human | Sphingosine 1-Phosphate | None | 1 | Small molecule | 8.4 | 9.1 | 9.8 | Refs | |||
| A (Rhodopsin) | Bile acid | GPBAR | GPBA | Human | Deoxycholic Acid | None | 2 | Small molecule | 6.2 | 6.2 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Mouse | Pge1 | None | 1 | Small molecule | 9.4 | 9.4 | 9.0 | 9.0 | Refs | ||
| A (Rhodopsin) | Lysophospholipid (LPA) | LPAR2 | LPA2 | Human | Lpa | None | 1 | Small molecule | 6.7 | 7.5 | 8.2 | Refs | |||
| A (Rhodopsin) | Adren | ADA1D | α1D-adren | Human | (-)-Noradrenaline | None | 2 | Small molecule | 6.3 | 6.3 | Refs | ||||
| A (Rhodopsin) | Dopamine | DRD1 | D1 | Human | 5-Hydroxytryptamine | None | 1 | Small molecule | 5.0 | 5.0 | Refs | ||||
| B1 (Secretin) | Parathyroid hormone | PTH1R | PTH1 | Human | Pth | 3 | Peptide | ||||||||
| A (Rhodopsin) | Chemokine | ACKR3 | ACKR3 | Human | Cxcl12Α | 1 | Peptide | 7.5 | 7.7 | 7.9 | Refs | ||||
| A (Rhodopsin) | Chemokine | CCR8 | CCR8 | Mouse | Ccl8 | 2 | Peptide | ||||||||
| A (Rhodopsin) | Lysophospholipid (S1P) | S1PR4 | S1P4 | Human | Sphingosine 1-Phosphate | None | 1 | Small molecule | 7.2 | 7.1 | 7.1 | Refs | |||
| A (Rhodopsin) | Neurotensin | NTR2 | NTS2 | Human | Neurotensin | 1 | Peptide | 8.8 | 8.8 | Refs | |||||
| A (Rhodopsin) | Galanin | GALR3 | GAL3 | Human | Galanin | 2 | Peptide | 8.1 | 8.5 | 8.8 | Refs | ||||
| A (Rhodopsin) | Chemokine | CCR4 | CCR4 | Human | Ccl22 | 3 | Peptide | ||||||||
| B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Human | Phm | 4 | Peptide | ||||||||
| A (Rhodopsin) | Adren | ADRB3 | β3-adren | Mouse | (&Plusmn;)-Adrenaline | None | 1 | Small molecule | 3.9 | 5.3 | 5.3 | Refs | |||
| A (Rhodopsin) | Proteinase-activated | PAR4 | PAR4 | Human | Thrombin | Peptide | |||||||||
| A (Rhodopsin) | Adren | ADA1A | α1A-adren | Human | (-)-Adrenaline | None | 1 | Small molecule | 6.3 | 6.4 | 6.5 | Refs | |||
| A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Mouse | Pgf2Α | None | 3 | Small molecule | 6.2 | 6.4 | 6.4 | Refs | |||
| A (Rhodopsin) | Histamine | HRH4 | H4 | Rat | Histamine | None | 1 | Small molecule | 7.8 | 8.1 | 8.3 | Refs | |||
| A (Rhodopsin) | Neurotensin | NTR2 | NTS2 | Mouse | Xenin | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | Chemokine | ACKR1 | ACKR1 | Human | Ccl5 | Peptide | |||||||||
| A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Rat | Pgf2Α | None | 3 | Small molecule | 6.2 | 6.4 | 6.4 | Refs | |||
| A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Mouse | Srif-14 | 3 | Peptide | 8.4 | 9.2 | 9.9 | Refs | ||||
| A (Rhodopsin) | Dopamine | DRD3 | D3 | Human | Dopamine | Principal | 1 | Small molecule | 6.4 | 6.9 | 7.3 | Refs | |||
| A (Rhodopsin) | Acetylcholine receptors (muscarinic) | ACM2 | M2 | Human | Acetylcholine | Principal | 1 | Small molecule | 4.3 | 5.4 | 6.5 | Refs | |||
| A (Rhodopsin) | Glycoprotein hormone | TSHR | TSH | Human | Tsh | Principal | 1 | Peptide | |||||||
| A (Rhodopsin) | Bombesin | NMBR | BB1 | Human | Neuromedin B | 1 | Peptide | 8.1 | 9.2 | 10.3 | Refs | ||||
| A (Rhodopsin) | Galanin | GALR3 | GAL3 | Rat | Galanin-Like Peptide | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT5A | 5-HT5A | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.0 | 6.3 | 6.6 | Refs | |||
| A (Rhodopsin) | Endothelin | EDNRB | ETB | Human | Endothelin-3 | 1 | Peptide | Refs | |||||||
| A (Rhodopsin) | Free fatty acid | FFAR4 | FFA4 | Human | Myristic Acid | None | 2 | Small molecule | 5.2 | 5.2 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Human | Pgf2Α | None | 3 | Small molecule | 6.1 | 6.1 | 9.1 | 9.3 | 9.5 | Refs | |
| C (Glutamate) | Metabotropic glutamate | GRM4 | mGlu4 | Rat | L-Serine-O-Phosphate | None | 1 | Small molecule | 5.9 | 5.9 | Refs | ||||
| C (Glutamate) | Metabotropic glutamate | GRM2 | mGlu2 | Rat | L-Glutamic Acid | Principal | 1 | Small molecule | 4.7 | 5.1 | 5.4 | 5.4 | 5.7 | 5.9 | Refs |
| A (Rhodopsin) | Leukotriene | LT4R1 | BLT1 | Human | 12r-Hete | None | 3 | Small molecule | 7.5 | 7.5 | Refs | ||||
| A (Rhodopsin) | Melanocortin | MC5R | MC5 | Human | Β-Msh | 2 | Peptide | ||||||||
| B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Human | Corticotrophin-Releasing Hormone | 1 | Peptide | 7.8 | 7.8 | Refs | |||||
| A (Rhodopsin) | Orexin | OX1R | OX1 | Human | Orexin-B | 2 | Peptide | 5.8 | 7.5 | 9.2 | Refs | ||||
| B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Human | Pacap-27 | 2 | Peptide | 7.6 | 8.6 | 9.9 | 8.9 | 8.9 | Refs | ||
| A (Rhodopsin) | Adren | ADA1A | α1A-adren | Human | (-)-Noradrenaline | None | 2 | Small molecule | 5.8 | 6.1 | 6.4 | Refs | |||
| C (Glutamate) | Metabotropic glutamate | GRM7 | mGlu7 | Human | L-Serine-O-Phosphate | None | 1 | Small molecule | 4.5 | 4.5 | 4.4 | 4.4 | Refs | ||
| A (Rhodopsin) | Tachykinin | NK3R | NK3 | Mouse | Neurokinin A | 2 | Peptide | 7.4 | 7.4 | 5.5 | 5.9 | 6.3 | Refs | ||
| A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl13 | 4 | Peptide | 9.1 | 9.1 | Refs | |||||
| A (Rhodopsin) | Vasopressin and oxytocin | V1BR | V1B | Human | Oxytocin | 2 | Peptide | 5.7 | 6.4 | 7.0 | Refs | ||||
| A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Human | Tyramine | None | 3 | Small molecule | 6.2 | 6.7 | 7.1 | 6.4 | 6.4 | Refs | |
| B1 (Secretin) | Calcitonin | CALCR | CT | Human | Amylin | 3 | Peptide | 8.0 | 8.6 | 9.2 | Refs | ||||
| C (Glutamate) | Metabotropic glutamate | GRM1 | mGlu1 | Human | L-Glutamic Acid | Principal | 1 | Small molecule | 4.8 | 4.9 | 5.0 | 6.4 | 6.5 | 6.5 | Refs |
| A (Rhodopsin) | Tachykinin | NK3R | NK3 | Mouse | Neurokinin B | 1 | Peptide | 8.4 | 8.4 | 7.7 | 8.5 | 9.2 | Refs | ||
| A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Mouse | Β-Phenylethylamine | None | 2 | Small molecule | 6.3 | 6.9 | 7.4 | Refs | |||
| B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Human | Vip | 3 | Peptide | 6.0 | 7.0 | 8.7 | 5.5 | 5.7 | 5.8 | Refs | |
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT4R | 5-HT4 | Rat | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 5.9 | 6.5 | 7.0 | ||||