Data showed in this table is continously collected from the Guide to Pharmacology database. Ref

Receptor Endogenous ligands pEC50 pKi References
Class Receptor family UniProt IUPHAR Species Ligand GtP
Classification
Potency
Ranking
Type Min Mid Max Min Mid Max
A (Rhodopsin) Adren ADRB1 β1-adren Human (-)-Adrenaline None 3 Small molecule 5.4 5.7 6.0 Refs
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Fmet-Leu-Phe None 2 Peptide
A (Rhodopsin) Somatostatin SSR3 SST3 Rat Srif-14 4 Peptide 8.7 8.9 8.9 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Rat Bradykinin 4 Peptide 5.1 6.7 6.7 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Mouse Srif-14 1 Peptide 9.0 9.1 9.1 8.9 9.7 10.5 Refs
A (Rhodopsin) Tachykinin NK2R NK2 Guinea pig Neurokinin A Principal 1 Peptide 8.9 8.9 8.0 8.6 9.1 Refs
C (Glutamate) Calcium-sensing CASR CaS Rat Ca2+ None 2 Small molecule Refs
A (Rhodopsin) Adren ADRB3 β3-adren Rat (-)-Adrenaline None 1 Small molecule
A (Rhodopsin) Chemerin CML1 hemerin Human 18r-Hepe 2 Small molecule
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Prp106-126 None 8 Peptide 4.6 4.6 Refs
A (Rhodopsin) Free fatty acid FFAR1 FFA1 Human Myristic Acid None 3 Small molecule 4.5 4.8 5.1 Refs
C (Glutamate) Metabotropic glutamate GRM5 mGlu5 Human L-Glutamic Acid Principal 1 Small molecule 5.0 5.3 5.5 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Desulfated Gastrin-14 6 Peptide
A (Rhodopsin) Neuropeptide Y NPY2R Y2 Human Peptide Yy Secondary 2 Peptide 9.5 9.7 9.8 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Human Vasopressin Principal 1 Peptide 8.5 8.4 8.4 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Pgf Secondary 2 Small molecule 6.2 6.3 6.3 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Human Cst-17 2 Peptide 8.8 9.1 9.3 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Mouse Pgd2 None 1 Small molecule 7.4 7.5 7.5 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Cxcl10 Secondary 2 Peptide
A (Rhodopsin) Orexin OX1R OX1 Human Orexin-A 1 Peptide 6.5 8.4 10.2 Refs
A (Rhodopsin) Apelin APJ apelin Human Apelin-17 2 Peptide Refs
A (Rhodopsin) Class A orphan GP139 GPR139 Human L-Phenylalanine None 2 Small molecule 3.5 3.5 3.1 3.1 Refs
A (Rhodopsin) Prostanoid PI2R IP Human Pge1 Secondary 2 Small molecule 6.5 7.5 7.5 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Human Pancreatic Polypeptide Secondary 2 Peptide 10.5 10.6 10.6 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1F 5-HT1F Human 5-Hydroxytryptamine Principal 1 Small molecule 7.7 7.9 8.0 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Rat Vip Principal 1 Peptide 7.9 9.0 10.0 8.5 9.2 9.8 Refs
B1 (Secretin) Glucagon receptor family SCTR secretin Rat Vip 2 Peptide Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl3 Secondary 2 Peptide
A (Rhodopsin) Vasopressin and oxytocin V1BR V1B Human Vasopressin Principal 1 Peptide 9.0 9.9 9.9 Refs
A (Rhodopsin) Opioid OPRK κ Mouse Dynorphin B 5 Peptide 8.1 9.0 9.9 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Rat Srif-28 3 Peptide 9.8 9.0 9.0 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Human Cortistatin-14 1 Peptide 9.1 9.5 9.9 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Rat [Des-Arg10]Kallidin 2 Peptide 8.7 8.8 8.8 Refs
A (Rhodopsin) Peptide P518 QRFPR QRFP Mouse Qrfp43 (43rfa) 3 Peptide 6.9 7.8 8.6 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Pge2 Principal 1 Small molecule 6.1 6.1 8.5 9.0 9.0 Refs
A (Rhodopsin) Prostanoid PI2R IP Human Pgi2 Principal 1 Small molecule 7.8 7.8 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Mouse Β-Phenylethylamine None 3 Small molecule 6.4 6.5 6.6 Refs
A (Rhodopsin) Neurotensin NTR1 NTS1 Human Neuromedin N 3 Peptide
A (Rhodopsin) Bradykinin BKRB2 B2 Human Bradykinin 1 Peptide Refs
A (Rhodopsin) Prostanoid PF2R FP Human Pge2 Secondary 2 Small molecule 6.4 7.0 7.0 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl5 Secondary 2 Peptide 8.5 8.9 9.3 Refs
A (Rhodopsin) Adren ADA1D α1D-adren Rat (-)-Adrenaline None 2 Small molecule 6.3 6.3 Refs
A (Rhodopsin) Vasopressin and oxytocin V1BR V1B Rat Vasopressin Principal 1 Peptide 9.0 9.9 9.9 Refs
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl22 Peptide
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide W-30 5 Peptide
A (Rhodopsin) Somatostatin SSR2 SST2 Mouse Srif-28 2 Peptide 8.4 9.3 10.2 Refs
A (Rhodopsin) Class A orphan LGR4 LGR4 Human R-Spondin-2 1 Peptide 12.5 12.5 Refs
A (Rhodopsin) Prostanoid PD2R DP1 Human Pgd2 Principal 1 Small molecule 7.8 7.7 7.7 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Rat Pacap-38 Principal 1 Peptide 9.5 9.8 10.0 6.9 8.2 9.0 Refs
A (Rhodopsin) Apelin APJ apelin Human Apelin-13 2 Peptide Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Pge1 Secondary 2 Small molecule 7.0 7.0 Refs
A (Rhodopsin) Galanin GALR1 GAL1 Human Galanin 2 Peptide 9.2 9.6 9.9 Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Mouse Udp-Glucose None 4 Small molecule 5.9 7.7 9.5 Refs
A (Rhodopsin) Somatostatin SSR4 SST4 Human Srif-14 2 Peptide 8.4 8.9 9.3 Refs
A (Rhodopsin) Hydroxycarboxylic acid HCAR1 HCA1 Mouse L-Lactic Acid Proposed 1 Small molecule 1.3 2.1 2.9 Refs
A (Rhodopsin) Relaxin family peptide RL3R1 RXFP3 Human Relaxin-3 1 Peptide 8.3 9.1 9.9 7.8 8.4 8.9 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Human Uridine Diphosphate None 3 Small molecule 7.1 7.1 Refs
A (Rhodopsin) Dopamine DRD2 D2 Rat Dopamine Principal 1 Small molecule 5.3 5.9 6.4 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT4R 5-HT4 Human 5-Hydroxytryptamine Principal 1 Small molecule 6.7 7.5 8.2 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR4 S1P4 Mouse Sphingosine 1-Phosphate None 1 Small molecule 7.2 7.1 7.1 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Mouse Pge1 Secondary 2 Small molecule 8.0 8.0 Refs
A (Rhodopsin) Neurotensin NTR2 NTS2 Rat Neurotensin 1 Peptide 8.8 8.8 Refs
A (Rhodopsin) P2Y P2RY4 P2Y4 Human Atp None 2 Small molecule 5.7 5.4 5.4 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT7R 5-HT7 Human 5-Hydroxytryptamine Principal 1 Small molecule 8.1 8.9 9.6 Refs
A (Rhodopsin) Vasopressin and oxytocin V2R V2 Human Vasopressin Principal 1 Peptide 7.9 8.5 9.1 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl28 Secondary 2 Peptide
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Vip Principal 1 Peptide 7.3 8.3 9.3 7.8 8.4 8.8 Refs
B1 (Secretin) Calcitonin CALCR CT Human Calcitonin Principal 1 Peptide 9.0 10.1 11.2 Refs
A (Rhodopsin) Relaxin family peptide RL3R2 RXFP4 Human Relaxin-3 1 Peptide 8.7 9.2 9.7 8.8 8.9 9.0 Refs
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Cck-4 2 Peptide
A (Rhodopsin) Somatostatin SSR5 SST5 Human Srif-28 3 Peptide 9.8 9.0 9.0 Refs
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Annexin I 2 Peptide
A (Rhodopsin) Dopamine DRD1 D1 Human (-)-Noradrenaline None 3 Small molecule
A (Rhodopsin) Prostanoid PE2R2 EP2 Human Pge1 Secondary 2 Small molecule 8.0 8.0 Refs
A (Rhodopsin) Ghrelin GHSR ghrelin Human [Des-Gln14]Ghrelin 2 Peptide
A (Rhodopsin) Free fatty acid FFAR2 FFA2 Human Acetic Acid None 2 Small molecule 3.1 3.9 4.6 Refs
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Cck-33 2 Peptide
A (Rhodopsin) Galanin GALR1 GAL1 Rat Galanin 1 Peptide 9.8 9.8 9.3 9.8 10.3 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR1 CRF1 Human Urocortin 1 1 Peptide Refs
A (Rhodopsin) Gonadotrophin-releasing hormone GNRHR GnRH1 Mouse Gnrh I 1 Peptide 7.8 7.9 7.9 7.3 8.0 8.4 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Rat Kallidin 3 Peptide 7.0 8.0 8.9 Refs
A (Rhodopsin) Ghrelin GHSR ghrelin Human Ghrelin 1 Peptide 7.2 8.1 9.5 7.8 8.0 8.1 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl26 Principal 1 Peptide Refs
A (Rhodopsin) Tachykinin NK2R NK2 Human Neurokinin A Principal 1 Peptide 8.9 8.9 8.0 8.6 9.1 Refs
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Cxcl5 Peptide
A (Rhodopsin) GPR18, GPR55 and GPR119 GPR55 GPR55 Human N-Palmitoylethanolamine None 2 Small molecule 8.4 8.4 Refs
A (Rhodopsin) Chemokine CCR6 CCR6 Human Ccl20 1 Peptide Refs
A (Rhodopsin) Vasopressin and oxytocin V2R V2 Human Oxytocin Secondary 2 Peptide 5.4 6.1 6.8 Refs
A (Rhodopsin) Chemokine CX3C1 CX3CR1 Human Cx3Cl1 Principal 1 Peptide
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl8 2 Peptide 8.8 6.4 6.4 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Mouse Pge2 Principal 1 Small molecule 6.1 6.1 8.5 9.0 9.0 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT2C 5-HT2C Human 5-Hydroxytryptamine Principal 1 Small molecule 6.7 7.3 7.9 Refs
A (Rhodopsin) Neurotensin NTR1 NTS1 Human Large Neuromedin N 3 Peptide Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Mouse Pgf Secondary 2 Small molecule 8.4 8.4 6.7 6.7 Refs
A (Rhodopsin) GPR18, GPR55 and GPR119 GPR55 GPR55 Human 2-Arachidonoylglycerolphosphoinositol None 5 Small molecule Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Mouse Pge2 Principal 1 Small molecule 9.4 9.4 9.0 9.0 Refs
A (Rhodopsin) Galanin GALR2 GAL2 Rat Galanin 1 Peptide 7.9 8.5 9.1 8.6 8.9 9.1 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Rat Pge2 Principal 1 Small molecule 9.4 9.4 9.0 9.0 Refs
A (Rhodopsin) Leukotriene OXER1 OXE Human 5-Oxo-20-Hete None 6 Small molecule 6.5 6.5 Refs
A (Rhodopsin) Somatostatin SSR4 SST4 Rat Srif-14 2 Peptide 8.4 8.9 9.3 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT5A 5-HT5A Rat 5-Hydroxytryptamine Principal 1 Small molecule 6.7 6.6 6.6 Refs
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Cathepsin G 2 Peptide
A (Rhodopsin) Leukotriene LT4R2 BLT2 Human 12-Hydroxyheptadecatrienoic Acid None 1 Small molecule 7.7 7.7 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Human Pacap-27 Principal 1 Peptide 7.4 8.9 10.6 6.9 8.0 8.5 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Des-Br-Neuropeptide B-23 4 Peptide Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide B-29 5 Peptide
A (Rhodopsin) Neurotensin NTR1 NTS1 Rat Neurotensin 1 Peptide 8.3 9.0 9.7 Refs
C (Glutamate) Metabotropic glutamate GRM1 mGlu1 Human L-Glutamic Acid Principal 1 Small molecule 4.8 4.9 5.0 6.4 6.5 6.5 Refs
A (Rhodopsin) Gonadotrophin-releasing hormone GNRHR GnRH1 Rat Gnrh I 1 Peptide 7.8 7.9 7.9 7.3 8.0 8.4 Refs
A (Rhodopsin) Tachykinin NK3R NK3 Human Substance P 3 Peptide 5.0 5.5 6.0 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Human Pacap-38 Principal 1 Peptide 9.5 9.8 10.0 6.9 8.2 9.0 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Human Tyramine None 2 Small molecule 6.2 6.7 7.1 6.4 6.4 Refs
A (Rhodopsin) Chemokine CX3C1 CX3CR1 Human Cx3Cl1 Principal 1 Peptide Refs
A (Rhodopsin) Melanocortin MSHR MC1 Mouse Agouti Secondary 2 Peptide Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Rat Udp-Galactose None 4 Small molecule 7.0 7.0 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Mouse Pge2 None 5 Small molecule 5.5 5.5 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Vip Principal 1 Peptide 7.9 9.0 10.0 8.5 9.2 9.8 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Rat Peptide Yy Principal 1 Peptide 6.3 7.0 8.5 Refs
A (Rhodopsin) Orexin OX1R OX1 Human Orexin-B 2 Peptide 5.8 7.5 9.2 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT4R 5-HT4 Rat 5-Hydroxytryptamine Principal 1 Small molecule 6.7 7.5 8.2 Refs
A (Rhodopsin) Opioid OPRK κ Mouse Β-Endorphin 7 Peptide 6.3 6.8 6.8 Refs
A (Rhodopsin) Prostanoid PI2R IP Mouse Pge1 Secondary 2 Small molecule 6.5 7.5 7.5 Refs
A (Rhodopsin) Somatostatin SSR4 SST4 Human Srif-28 4 Peptide 8.1 8.7 9.2 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Human Udp-Glucuronic Acid None 2 Small molecule 7.2 7.2 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl7 8 Peptide
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Human Oxytocin Secondary 2 Peptide 6.9 7.6 8.3 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR4 LPA4 Mouse Lpa None 1 Small molecule Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Mouse Cst-17 1 Peptide 8.8 9.3 9.8 Refs
C (Glutamate) Class C Orphan GPC6A GPRC6 Human L-Ornithine None 2 Small molecule 4.0 4.0 Refs
A (Rhodopsin) Melanin-concentrating hormon MCHR1 MCH1 Rat Melanin-Concentrating Hormone Principal 1 Peptide 9.7 10.1 10.5 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT5A 5-HT5A Mouse 5-Hydroxytryptamine Principal 1 Small molecule 6.7 6.6 6.6 Refs
A (Rhodopsin) Neurotensin NTR1 NTS1 Human Neurotensin 1 Peptide 8.3 9.0 9.7 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Rat Srif-14 1 Peptide 9.0 9.1 9.1 8.9 9.7 10.5 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Rat Β-Phenylethylamine None 3 Small molecule 6.4 6.5 6.6 Refs
A (Rhodopsin) Orexin OX2R OX2 Human Orexin-B 1 Peptide 6.5 8.3 10.0 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Human Srif-14 1 Peptide 9.0 9.1 9.1 8.9 9.7 10.5 Refs
A (Rhodopsin) P2Y P2Y11 P2Y11 Human Adp 3 Small molecule
A (Rhodopsin) Prostanoid PF2R FP Mouse Pge2 Secondary 2 Small molecule 6.4 7.0 7.0 Refs
A (Rhodopsin) Tachykinin NK1R NK1 Human Neuropeptide K 4 Peptide Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Human Corticotrophin-Releasing Hormone 1 Peptide 7.8 7.8 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Rat Galanin 2 Peptide 7.3 7.3 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl7 8 Peptide
A (Rhodopsin) 5-Hydroxytryptamine 5HT6R 5-HT6 Human 5-Hydroxytryptamine Principal 1 Small molecule 6.8 7.2 7.5 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl7 Secondary 2 Peptide
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Secretin Secondary 2 Peptide
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Rat Pyy-(3-36) Secondary 2 Peptide 6.2 6.2 Refs
B1 (Secretin) Calcitonin CALCR CT Human Α-Cgrp Secondary 2 Peptide
A (Rhodopsin) Bombesin GRPR BB2 Human Gastrin-Releasing Peptide 2 Peptide 6.3 7.3 8.2 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Rat Udp-Glucose None 1 Small molecule 7.7 7.7 Refs
A (Rhodopsin) Adren ADRB3 β3-adren Rat (-)-Noradrenaline None 2 Small molecule 4.7 4.2 4.2 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Human Vip Secondary 2 Peptide 6.0 7.0 8.7 6.0 6.9 8.4 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR2 LPA2 Mouse Lpa None 1 Small molecule 8.0 8.1 8.2 Refs
C (Glutamate) Calcium-sensing CASR CaS Rat Mg2+ None 3 Small molecule Refs
A (Rhodopsin) Adren ADRB3 β3-adren Human (-)-Noradrenaline None 2 Small molecule 4.7 4.2 4.2 Refs
A (Rhodopsin) Adenosine AA3R A3 Rat Adenosine Principal 1 Small molecule 6.5 6.5 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Mouse Srif-28 3 Peptide 8.1 9.0 9.9 Refs
A (Rhodopsin) Bombesin GRPR BB2 Mouse Gastrin-Releasing Peptide 2 Peptide 6.3 7.3 8.2 Refs
A (Rhodopsin) Angiotensin AGTR1 AT1 Human Angiotensin A 1 Peptide 8.2 8.2 8.8 8.8 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Mouse Urocortin 3 2 Peptide Refs
A (Rhodopsin) Free fatty acid FFAR2 FFA2 Human Butyric Acid None 4 Small molecule 2.9 3.8 4.6 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1B 5-HT1B Human 5-Hydroxytryptamine None 1 Small molecule 7.4 8.2 9.0 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Rat Urocortin 1 2 Peptide Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl11 Secondary 2 Peptide Refs
A (Rhodopsin) Complement peptide C3AR C3a Human C5a 2 Peptide
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Rat Pancreatic Polypeptide Secondary 2 Peptide 10.5 10.6 10.6 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide W-30 1 Peptide Refs
A (Rhodopsin) Prolactin-releasing peptide PRLHR PrRP Human Prrp-20 1 Peptide 9.0 9.3 9.6 Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Aspirin-Triggered Resolvin D1 None 3 Small molecule 11.1 11.1 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Rat Pge1 Secondary 2 Small molecule 7.0 7.0 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Mouse Pge1 Secondary 2 Small molecule 9.5 9.5 8.7 8.7 Refs
A (Rhodopsin) Histamine HRH4 H4 Human Histamine None 1 Small molecule 7.8 7.4 7.4 Refs
C (Glutamate) Calcium-sensing CASR CaS Human Spermine None 1 Small molecule Refs
A (Rhodopsin) Angiotensin AGTR1 AT1 Human Angiotensin Iv 2 Peptide 5.9 5.9 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Human Kallidin 3 Peptide 7.0 8.0 8.9 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Human Phm Secondary 2 Peptide
A (Rhodopsin) Neuromedin U NMUR1 NMU1 Human Neuromedin U-23 3 Peptide
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Rat Vip Principal 1 Peptide 7.3 8.3 9.3 7.8 8.4 8.8 Refs
A (Rhodopsin) Prostanoid PF2R FP Human Pgi2 Secondary 2 Small molecule
A (Rhodopsin) Adren ADRB2 β2-adren Human Zn2+ None 4 Small molecule 3.3 4.3 5.3 Refs
C (Glutamate) Metabotropic glutamate GRM6 mGlu6 Human L-Glutamic Acid None 2 Small molecule 4.8 4.4 4.4 Refs
A (Rhodopsin) P2Y P2RY1 P2Y1 Human Atp None 1 Small molecule 4.8 4.8 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Mouse Srif-14 4 Peptide 8.7 8.9 8.9 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide W-30 5 Peptide
A (Rhodopsin) Lysophospholipid (LPA) LPAR2 LPA2 Human Lpa None 1 Small molecule 8.0 8.1 8.2 Refs
A (Rhodopsin) P2Y P2Y11 P2Y11 Human Atp None 2 Small molecule 4.2 4.9 5.6 Refs
A (Rhodopsin) Relaxin family peptide RL3R2 RXFP4 Human Insl5 3 Peptide 7.0 7.7 8.9 7.3 8.1 8.8 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl13 Secondary 2 Peptide Refs
A (Rhodopsin) Cannabinoid CNR2 CB2 Human Anandamide None 2 Small molecule 5.7 6.1 6.4 Refs
A (Rhodopsin) Leukotriene CLTR1 CysLT1 Human Ltc4 None 2 Small molecule 7.4 7.6 7.7 7.0 7.6 8.1 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Desulfated Cholecystokinin-8 None 3 Peptide Refs
C (Glutamate) Metabotropic glutamate GRM2 mGlu2 Human L-Glutamic Acid Principal 1 Small molecule 4.7 5.1 5.4 5.4 5.7 5.9 Refs
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl13 Peptide
A (Rhodopsin) Class A orphan GP183 GPR183 Human 7Α,27-Dihydroxycholesterol None 2 Small molecule 8.9 8.9 Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Human Ltd4 None 3 Small molecule 8.1 8.3 8.4 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR6 LPA6 Mouse Lpa Principal 1 Small molecule 6.0 6.0 Refs
A (Rhodopsin) Neuropeptide S NPSR1 NPS Human Neuropeptide S Principal 1 Peptide 7.3 7.7 8.0 Refs
A (Rhodopsin) Galanin GALR2 GAL2 Human Spexin-1 3 Peptide 6.8 6.8 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT2C 5-HT2C Rat 5-Hydroxytryptamine Principal 1 Small molecule 6.7 7.3 7.9 Refs
A (Rhodopsin) Adenosine AA2AR A2A Human Adenosine Principal 1 Small molecule 6.5 6.5 Refs
A (Rhodopsin) Free fatty acid FFAR4 FFA4 Human Oleic Acid None 4 Small molecule 4.7 4.7 Refs
B1 (Secretin) Glucagon receptor family GIPR GIP Rat Gastric Inhibitory Polypeptide Principal 1 Peptide 9.1 9.1 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl3 Secondary 2 Peptide 7.8 9.0 10.2 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Mouse Srif-28 3 Peptide 9.8 9.0 9.0 Refs
A (Rhodopsin) Galanin GALR2 GAL2 Human Galanin 1 Peptide 7.9 8.5 9.1 8.6 8.9 9.1 Refs
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Cck-8 2 Peptide Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl7 Secondary 2 Peptide
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl5 Secondary 2 Peptide 6.8 7.5 8.2 Refs
A (Rhodopsin) Opioid OPRX NOP Human Nociceptin/Orphanin Fq Principal 1 Peptide 8.4 9.1 9.8 9.7 9.4 9.4 Refs
A (Rhodopsin) Chemokine CXCR5 CXCR5 Human Cxcl13 Principal 1 Peptide
A (Rhodopsin) Chemerin CML1 hemerin Human Resolvin E1 None 2 Small molecule Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Rat Vip Secondary 2 Peptide 6.0 7.0 8.7 6.0 6.9 8.4 Refs
A (Rhodopsin) Somatostatin SSR1 SST1 Human Srif-28 3 Peptide 8.6 9.0 9.4 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Rat Pgd2 Secondary 2 Small molecule 5.3 5.3 Refs
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Cathepsin G 2 Peptide
A (Rhodopsin) Lysophospholipid (LPA) LPAR5 LPA5 Human N-Arachidonoylglycine None 4 Small molecule 4.3 4.3 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT4R 5-HT4 Mouse 5-Hydroxytryptamine Principal 1 Small molecule 6.7 7.5 8.2 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR2 LPA2 Human Farnesyl Diphosphate None 2 Small molecule Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Human Srif-14 4 Peptide 7.7 8.4 9.1 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Human Neuropeptide Y Secondary 2 Peptide 6.4 7.2 8.8 Refs
A (Rhodopsin) Orexin OX2R OX2 Human Orexin-A 1 Peptide 6.5 8.3 10.0 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl7 Secondary 2 Peptide Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Pge1 Secondary 2 Small molecule 9.5 9.5 8.7 8.7 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Human Galanin 2 Peptide 8.1 8.5 8.8 Refs
C (Glutamate) Metabotropic glutamate GRM4 mGlu4 Human L-Serine-O-Phosphate None 1 Small molecule 5.9 5.9 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Mouse Pancreatic Polypeptide Secondary 2 Peptide 10.3 10.7 10.7 Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Humanin 6 Peptide 6.0 6.5 7.0 Refs
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Rat Pthrp-(1-34) (Human) None 2 Peptide Refs
A (Rhodopsin) Urotensin UR2R UT Mouse Urotensin-Ii 2 Peptide 8.2 8.6 9.0 Refs
A (Rhodopsin) Opioid OPRK κ Rat Dynorphin A-(1-13) 2 Peptide 9.3 10.0 10.7 Refs
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM3 M3 Human Acetylcholine Principal 1 Small molecule 4.5 5.0 5.4 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1B 5-HT1B Mouse 5-Hydroxytryptamine None 1 Small molecule 7.4 8.2 9.0 Refs
A (Rhodopsin) Neuromedin U NMUR2 NMU2 Human Neuromedin U-25 2 Peptide 8.4 8.9 9.4 9.6 9.6 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Rat Vasopressin Principal 1 Peptide 8.5 8.4 8.4 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Pgd2 Secondary 2 Small molecule 5.2 5.2 Refs
A (Rhodopsin) Melanocortin MC4R MC4 Human Α-Msh Secondary 2 Peptide 7.4 7.7 8.0