Data showed in this table is continously collected from the Guide to Pharmacology database. Ref

RECEPTOR ENDOGENOUS LIGANDS pEC50 pKi REFERENCES
Class Receptor family UniProt IUPHAR Species Ligand GtP
Classification
Potency
Ranking
Type Min Mid Max Min Mid Max
A (Rhodopsin) 5-Hydroxytryptamine 5HT1F 5-HT1F Human 5-Hydroxytryptamine Principal 1 Small molecule 7.7 7.9 8.0 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT4R 5-HT4 Rat 5-Hydroxytryptamine Principal 1 Small molecule 6.7 7.5 8.2 Refs
A (Rhodopsin) Thyrotropin-releasing hormone TRFR TRH1 Human Trh Principal 1 Peptide 7.4 7.4 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR3 LPA3 Human Farnesyl Monophosphate None 2 Small molecule Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl2 1 Peptide Refs
A (Rhodopsin) Dopamine DRD3 D3 Human Dopamine Principal 1 Small molecule 6.4 6.9 7.3 Refs
A (Rhodopsin) Galanin GALR2 GAL2 Rat Galanin 2 Peptide 8.3 8.3 8.3 8.4 8.4 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl3 5 Peptide 8.0 8.5 8.9 Refs
C (Glutamate) Metabotropic glutamate GRM8 mGlu8 Human L-Glutamic Acid None 1 Small molecule 4.9 5.3 5.6 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR3 S1P3 Human Sphingosylphosphorylcholine 2 Small molecule
A (Rhodopsin) Leukotriene OXER1 OXE Human 5-Oxo-20-Hete None 6 Small molecule 6.5 6.5 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl16 7 Peptide
C (Glutamate) Metabotropic glutamate GRM4 mGlu4 Rat L-Glutamic Acid None 2 Small molecule 4.7 5.1 5.5 4.9 5.2 5.5 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Prrp-31 3 Peptide
A (Rhodopsin) Class A orphan GPR35 GPR35 Human Kynurenic Acid None 2 Small molecule 3.9 5.0 5.0 Refs
A (Rhodopsin) Leukotriene CLTR1 CysLT1 Human Ltc4 None 2 Small molecule 7.4 7.6 7.7 7.0 7.6 8.1 Refs
A (Rhodopsin) Melatonin MTR1B MT2 Human Melatonin Principal 1 Small molecule 9.4 9.6 9.8 Refs
A (Rhodopsin) P2Y P2RY4 P2Y4 Human Atp None 2 Small molecule 5.7 5.4 5.4 Refs
A (Rhodopsin) Prostanoid PD2R DP1 Mouse Pgd2 None 2 Small molecule 7.8 8.5 9.2 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Human Srif-14 1 Peptide 8.7 9.4 10.0 Refs
A (Rhodopsin) Proteinase-activated PAR4 PAR4 Human Cathepsin G Peptide
A (Rhodopsin) Vasopressin and oxytocin OXYR OT Human Vasopressin 2 Peptide 7.3 8.3 9.3 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Rat Srif-14 1 Peptide 9.0 9.1 9.1 8.9 9.7 10.5 Refs
A (Rhodopsin) Chemokine CX3C1 CX3CR1 Human Cx3Cl1 Principal 1 Peptide
A (Rhodopsin) Class A orphan LGR5 LGR5 Human R-Spondin-3 3 Peptide 11.0 11.0 Refs
A (Rhodopsin) Proteinase-activated PAR4 PAR4 Human Cathepsin G Peptide
A (Rhodopsin) Prolactin-releasing peptide PRLHR PrRP Human Prrp-31 4 Peptide
A (Rhodopsin) Class A orphan LGR5 LGR5 Human R-Spondin-2 1 Peptide 12.0 12.0 Refs
A (Rhodopsin) Proteinase-activated PAR4 PAR4 Human Thrombin Peptide
A (Rhodopsin) Adren ADRB3 β3-adren Rat (&Plusmn;)-Adrenaline None 1 Small molecule 3.9 5.3 5.3 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Rat Pge1 None 2 Small molecule 7.0 7.0 Refs
A (Rhodopsin) Somatostatin SSR4 SST4 Human Srif-14 2 Peptide 8.4 8.9 9.3 Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Mouse Ltd4 None 3 Small molecule 8.1 8.3 8.4 Refs
A (Rhodopsin) Opioid OPRD δ Human Dynorphin A 5 Peptide 7.4 7.4 Refs
A (Rhodopsin) Class A orphan GPR39 GPR39 Human Zn2+ None Small molecule Refs
A (Rhodopsin) Chemokine CXCR4 CXCR4 Human Cxcl12Γ 3 Peptide Refs
A (Rhodopsin) Orexin OX2R OX2 Human Orexin-B 1 Peptide 6.5 8.3 10.0 Refs
A (Rhodopsin) Neuromedin U NMUR1 NMU1 Human Neuromedin S-36 3 Peptide
A (Rhodopsin) Prostanoid PE2R4 EP4 Rat Pge2 None 3 Small molecule 6.1 6.1 8.5 8.6 8.7 Refs
A (Rhodopsin) Chemerin CML1 hemerin Human 18r-Hepe 2 Small molecule
A (Rhodopsin) Class A orphan GPR17 GPR17 Mouse Udp-Glucose None 6 Small molecule 7.1 7.2 7.3 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Rat Pgf None 2 Small molecule 8.4 8.4 7.4 7.4 Refs
A (Rhodopsin) Opioid OPRD δ Human Β-Endorphin 7 Peptide
A (Rhodopsin) Opioid OPRK κ Mouse Dynorphin B 5 Peptide 8.1 9.0 9.9 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1E 5-HT1E Human 5-Hydroxytryptamine None 1 Small molecule 8.0 8.1 8.2 Refs
A (Rhodopsin) GPR18, GPR55 and GPR119 GPR55 GPR55 Human Lysophosphatidylinositol None 4 Small molecule 5.5 6.4 7.3 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT2B 5-HT2B Human 5-Hydroxytryptamine Principal 1 Small molecule 7.9 8.2 8.4 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Rat Galanin-Like Peptide 2 Peptide Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR5 LPA5 Human Lpa None 3 Small molecule 4.3 6.1 7.9 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Rat Vip 3 Peptide 6.0 7.0 8.7 6.0 6.9 8.4 Refs
A (Rhodopsin) Tachykinin NK1R NK1 Human Neuropeptide-Γ None 4 Peptide Refs
A (Rhodopsin) Adren ADA2B α2B-adren Human (-)-Adrenaline None 2 Small molecule 5.2 5.2 Refs
A (Rhodopsin) Peptide P518 QRFPR QRFP Human Qrfp26 (26rfa) 2 Peptide 8.1 8.1 Refs
A (Rhodopsin) Leukotriene CLTR1 CysLT1 Human Lte4 None 3 Small molecule 6.4 6.7 7.2 7.1 7.5 7.8 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Vip 1 Peptide 7.9 9.0 10.0 8.5 9.2 9.8 Refs
A (Rhodopsin) Galanin GALR1 GAL1 Rat Galanin 1 Peptide 9.8 9.8 9.3 9.8 10.3 Refs
A (Rhodopsin) Class A orphan LGR6 LGR6 Human R-Spondin-1 Peptide Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Rat Pacap-27 2 Peptide 7.6 8.6 9.9 8.9 8.9 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Rat Pge2 None 2 Small molecule 7.5 7.9 8.3 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl7 4 Peptide Refs
A (Rhodopsin) Free fatty acid FFAR2 FFA2 Human Butyric Acid None 4 Small molecule 2.9 3.8 4.6 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Mouse Srif-28 2 Peptide 8.4 9.3 10.2 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Human Vasopressin 1 Peptide 8.5 8.9 9.3 Refs
A (Rhodopsin) Prolactin-releasing peptide PRLHR PrRP Human Prrp-20 1 Peptide 9.0 9.3 9.6 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Human Vip 3 Peptide 6.0 7.0 8.7 6.0 6.9 8.4 Refs
A (Rhodopsin) Relaxin family peptide RL3R1 RXFP3 Human Insl5 3 Peptide 7.0 7.0 Refs
B1 (Secretin) Glucagon receptor family GIPR GIP Human Gastric Inhibitory Polypeptide Principal 1 Peptide 9.1 9.1 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Rat Vip 1 Peptide 7.9 9.0 10.0 8.5 9.2 9.8 Refs
A (Rhodopsin) Galanin GALR1 GAL1 Human Galanin 2 Peptide 9.1 9.8 10.5 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR5 S1P5 Rat Sphingosine 1-Phosphate None 1 Small molecule 7.4 8.2 8.9 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR4 S1P4 Human Dihydrosphingosine 1-Phosphate None 2 Small molecule
A (Rhodopsin) Vasopressin and oxytocin V1BR V1B Rat Vasopressin 1 Peptide 9.0 9.3 9.5 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR3 S1P3 Mouse Sphingosine 1-Phosphate None 1 Small molecule 8.4 8.6 8.6 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Human Thromboxane A2 6 Small molecule
C (Glutamate) Metabotropic glutamate GRM4 mGlu4 Rat L-Serine-O-Phosphate None 1 Small molecule 5.9 5.9 Refs
A (Rhodopsin) Chemokine CCR10 CCR10 Human Ccl28 Peptide
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl7 8 Peptide
B1 (Secretin) Glucagon receptor family GIPR GIP Human Gastric Inhibitory Polypeptide Principal 1 Peptide
A (Rhodopsin) Histamine HRH3 H3 Mouse Histamine Principal 1 Small molecule 7.1 7.5 7.8 Refs
A (Rhodopsin) Orexin OX2R OX2 Human Orexin-A 1 Peptide 6.5 8.3 10.0 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Mouse Pge2 None 1 Small molecule 7.3 7.7 7.7 Refs
A (Rhodopsin) Chemokine XCR1 XCR1 Human Xcl1 1 Peptide 7.3 7.3 Refs
A (Rhodopsin) Galanin GALR1 GAL1 Mouse Galanin 1 Peptide 9.8 9.8 9.3 9.8 10.3 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Mouse Peptide Yy 5 Peptide 6.3 7.0 8.5 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1B 5-HT1B Human 5-Hydroxytryptamine None 1 Small molecule 7.4 8.1 8.1 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT7R 5-HT7 Rat 5-Hydroxytryptamine Principal 1 Small molecule 8.1 8.9 9.6 Refs
A (Rhodopsin) P2Y P2RY2 P2Y2 Human Utp None 1 Small molecule 8.1 8.1 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Human Galanin 2 Peptide 8.1 8.5 8.8 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR2 LPA2 Human Farnesyl Diphosphate None 2 Small molecule Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR4 LPA4 Mouse Lpa None 1 Small molecule Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Human Srif-28 2 Peptide 8.4 9.3 10.2 Refs
A (Rhodopsin) Opioid OPRM μ Human Dynorphin A-(1-8) 3 Peptide 8.4 8.4 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Pacap-27 2 Peptide 7.6 8.5 9.4 Refs
A (Rhodopsin) Orexin OX1R OX1 Human Orexin-A 1 Peptide 6.5 8.4 10.2 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT4R 5-HT4 Mouse 5-Hydroxytryptamine Principal 1 Small molecule 6.7 7.5 8.2 Refs
A (Rhodopsin) Vasopressin and oxytocin V2R V2 Human Vasopressin 1 Peptide 7.9 8.5 9.1 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR1 CRF1 Human Corticotrophin-Releasing Hormone 2 Peptide Refs
A (Rhodopsin) Adren ADA2C α2C-adren Human (-)-Adrenaline None 2 Small molecule 5.8 5.8 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Rat Oxytocin 2 Peptide 6.9 6.1 6.1 Refs
A (Rhodopsin) Vasopressin and oxytocin V1BR V1B Human Vasopressin 1 Peptide 9.0 9.3 9.5 Refs
C (Glutamate) Metabotropic glutamate GRM3 mGlu3 Human L-Glutamic Acid None 1 Small molecule 5.3 5.4 5.4 6.4 6.4 Refs
A (Rhodopsin) Adren ADA1D α1D-adren Human (-)-Adrenaline None 1 Small molecule 7.2 7.2 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Rat Pgf None 3 Small molecule 6.1 6.1 9.1 9.3 9.5 Refs
A (Rhodopsin) Chemokine CXCR6 CXCR6 Human Cxcl16 Principal 1 Peptide
A (Rhodopsin) 5-Hydroxytryptamine 5HT5A 5-HT5A Rat 5-Hydroxytryptamine Principal 1 Small molecule 6.0 6.3 6.6 Refs
A (Rhodopsin) Free fatty acid FFAR4 FFA4 Human Linoleic Acid None 1 Small molecule 5.9 5.9 Refs
A (Rhodopsin) Tachykinin NK1R NK1 Human Neurokinin A 2 Peptide 6.2 7.8 9.3 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Mouse Tyramine None 2 Small molecule 6.9 7.1 7.2 6.4 6.4 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Rat Pge2 None 1 Small molecule 7.3 7.7 7.7 Refs
A (Rhodopsin) Somatostatin SSR1 SST1 Human Srif-14 2 Peptide 8.6 9.1 9.5 Refs
A (Rhodopsin) Free fatty acid FFAR2 FFA2 Human Acetic Acid None 2 Small molecule 3.1 3.9 4.6 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR4 S1P4 Human Sphingosine 1-Phosphate None 1 Small molecule 7.2 7.1 7.1 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Pge2 None 1 Small molecule 7.3 7.7 7.7 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT4R 5-HT4 Human 5-Hydroxytryptamine Principal 1 Small molecule 6.7 7.5 8.2 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Human Cst-17 2 Peptide 8.5 9.4 10.2 Refs
A (Rhodopsin) Class A orphan GPR34 GPR34 Human Lysophosphatidylserine Principal 1 Small molecule 6.6 7.3 7.3 Refs
A (Rhodopsin) Dopamine DRD1 D1 Human Noradrenaline None 3 Small molecule 4.3 4.3 Refs
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl14 Peptide
B1 (Secretin) VIP and PACAP PACR PAC1 Human Pacap-27 1 Peptide 10.0 10.1 10.1 8.5 8.7 8.8 Refs
A (Rhodopsin) Prostanoid PD2R DP1 Human Thromboxane A2 6 Small molecule
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl8 3 Peptide Refs
A (Rhodopsin) Chemokine CXCR1 CXCR1 Human Cxcl8 1 Peptide 8.8 9.2 9.5 Refs
A (Rhodopsin) Prostanoid PF2R FP Mouse Pgf None 1 Small molecule 7.9 8.2 8.5 Refs
A (Rhodopsin) Galanin GALR2 GAL2 Human Spexin-1 3 Peptide 6.8 6.8 Refs
A (Rhodopsin) Opioid OPRK κ Human Dynorphin A-(1-8) 6 Peptide 8.0 9.0 9.9 Refs
A (Rhodopsin) Histamine HRH3 H3 Rat Histamine Principal 1 Small molecule 7.1 7.5 7.8 Refs
A (Rhodopsin) Free fatty acid FFAR4 FFA4 Human Α-Linolenic Acid None 3 Small molecule 5.1 5.1 Refs
A (Rhodopsin) P2Y P2RY4 P2Y4 Rat Atp None 2 Small molecule 5.7 5.4 5.4 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Mouse Bradykinin 5 Peptide 5.1 5.2 5.3 Refs
B1 (Secretin) Calcitonin CALCR CT Human Calcitonin (Salmon) None 2 Peptide 7.6 9.4 11.1 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Mouse Corticotrophin-Releasing Hormone 1 Peptide 7.8 7.8 Refs
A (Rhodopsin) Chemokine CXCR6 CXCR6 Human Cxcl16 Principal 1 Peptide Refs
B1 (Secretin) Glucagon receptor family GLP2R GLP-2 Human Glucagon-Like Peptide 2 4 Peptide Refs
A (Rhodopsin) P2Y P2RY4 P2Y4 Human Utp None 1 Small molecule 5.6 5.6 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Human Udp-Glucose None 1 Small molecule 7.6 7.6 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Rfrp-3 2 Peptide 7.8 7.8 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl1 2 Peptide 8.4 9.1 9.7 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Rat Pgd2 None 2 Small molecule 8.8 8.8 8.7 8.9 9.0 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Rat Pacap-27 1 Peptide 10.0 10.1 10.1 8.5 8.7 8.8 Refs
A (Rhodopsin) Relaxin family peptide RL3R2 RXFP4 Human Insl5 3 Peptide 7.0 7.7 8.9 7.3 8.1 8.8 Refs
A (Rhodopsin) Gonadotrophin-releasing hormone GNRHR GnRH1 Rat Gnrh I 1 Peptide 7.8 10.0 10.0 7.3 8.0 8.4 Refs
A (Rhodopsin) Prostanoid PF2R FP Human Pgf None 1 Small molecule 7.9 8.2 8.5 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl3 3 Peptide Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Mouse Udp N-Acetyl-Glucosamine None 4 Small molecule 6.8 6.8 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Secretin 4 Peptide
C (Glutamate) Calcium-sensing CASR CaS Mouse Ca2+ None 2 Small molecule Refs
C (Glutamate) Calcium-sensing CASR CaS Human L-Tryptophan None 1 Small molecule Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Rat Peptide Yy 5 Peptide 6.3 7.0 8.5 Refs
A (Rhodopsin) Relaxin family peptide RL3R1 RXFP3 Human Relaxin 2 Peptide 7.1 7.8 8.4 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1D 5-HT1D Human 5-Hydroxytryptamine None 1 Small molecule 8.0 8.5 9.0 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Human Spexin-1 1 Peptide 6.2 6.2 Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Agouti-Related Protein 2 Peptide Refs
A (Rhodopsin) Opioid OPRK κ Human Β-Endorphin 9 Peptide
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C3a 2 Peptide
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide W-23 5 Peptide
A (Rhodopsin) Somatostatin SSR1 SST1 Human Srif-28 3 Peptide 8.6 9.0 9.4 Refs
A (Rhodopsin) Bombesin NMBR BB1 Human Neuromedin B 1 Peptide 8.1 9.2 10.3 Refs
A (Rhodopsin) Ghrelin GHSR ghrelin Human Ghrelin 1 Peptide 7.2 8.1 9.5 7.8 8.0 8.1 Refs
A (Rhodopsin) Melanocortin MC4R MC4 Human Γ-Msh 3 Peptide
A (Rhodopsin) Urotensin UR2R UT Human Urotensin Ii-Related Peptide 4 Peptide Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Cck-33 2 Peptide Refs
C (Glutamate) Metabotropic glutamate GRM6 mGlu6 Human L-Glutamic Acid None 2 Small molecule 4.8 5.0 5.2 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl24 5 Peptide Refs
A (Rhodopsin) Bombesin GRPR BB2 Human Grp-(18-27) 3 Peptide
B1 (Secretin) Glucagon receptor family GLR glucagon Human Glucagon Principal 1 Peptide 9.0 9.0 Refs
A (Rhodopsin) Prostanoid PD2R DP1 Rat Pgd2 None 2 Small molecule 7.8 8.5 9.2 Refs
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Cck-33 2 Peptide
A (Rhodopsin) Relaxin family peptide RXFP1 RXFP1 Human Relaxin-3 3 Peptide 7.5 7.8 8.0 Refs
A (Rhodopsin) Complement peptide C5AR2 C5a2 Human C5a Des-Arg 2 Peptide 8.6 8.6 Refs
A (Rhodopsin) Adren ADRB1 β1-adren Human (-)-Adrenaline None 3 Small molecule 5.4 5.7 6.0 Refs
A (Rhodopsin) Formylpeptide FPR3 FPR3 Human F2l 4 Peptide
A (Rhodopsin) Opioid OPRK κ Mouse Dynorphin A 1 Peptide 10.0 10.2 10.3 Refs
A (Rhodopsin) Melanin-concentrating hormon MCHR1 MCH1 Rat Melanin-Concentrating Hormone Principal 1 Peptide 9.8 9.9 10.0 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Rat Pacap-38 2 Peptide 7.5 8.9 10.3 6.9 8.2 9.0 Refs
A (Rhodopsin) Melatonin MTR1A MT1 Human Melatonin Principal 1 Small molecule 9.1 9.4 9.7 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Rat Vasopressin 1 Peptide 8.5 8.9 9.3 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Neuropeptide Af 3 Peptide
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide B-29 3 Peptide Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Rat Pge2 None 1 Small molecule 9.4 9.4 9.1 9.1 Refs
A (Rhodopsin) Bombesin GRPR BB2 Human Gastrin-Releasing Peptide 1 Peptide 6.3 7.3 8.2 Refs
B1 (Secretin) Glucagon receptor family GIPR GIP Rat Gastric Inhibitory Polypeptide Principal 1 Peptide Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Human Pge2 None 2 Small molecule 7.5 7.9 8.3 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Human Pgf None 2 Small molecule 8.4 8.4 7.4 7.4 Refs
A (Rhodopsin) Dopamine DRD1 D1 Human 5-Hydroxytryptamine None 1 Small molecule 5.0 5.0 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Pgf None 3 Small molecule 6.2 5.9 5.9 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Human Phi 4 Peptide
A (Rhodopsin) Chemokine CCR3 CCR3 Human Cxcl9 5 Peptide
A (Rhodopsin) Class A orphan GPR17 GPR17 Mouse Lte4 None 1 Small molecule 9.5 9.5 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Human Β-Phenylethylamine None 3 Small molecule 6.2 6.6 7.0 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR2 LPA2 Human Farnesyl Monophosphate None 2 Small molecule Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Human Srif-14 3 Peptide 8.4 9.2 9.9 Refs
A (Rhodopsin) Tachykinin NK2R NK2 Human Substance P 2 Peptide 5.9 6.4 6.9 Refs
A (Rhodopsin) Histamine HRH4 H4 Human Histamine None 1 Small molecule 7.8 7.2 7.2 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Vip 3 Peptide 7.3 8.3 9.3 7.8 8.4 8.8 Refs
A (Rhodopsin) Leukotriene CLTR2 CysLT2 Human Ltd4 None 2 Small molecule 6.8 7.6 8.6 7.3 7.7 8.1 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Human Oxytocin 2 Peptide 6.9 6.1 6.1 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Mouse Srif-14 1 Peptide 8.7 9.4 10.0 Refs
A (Rhodopsin) Bile acid GPBAR GPBA Human Deoxycholic Acid None 2 Small molecule 6.2 6.2 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Human Galanin-Like Peptide 2 Peptide
A (Rhodopsin) Histamine HRH3 H3 Human Histamine Principal 1 Small molecule 7.1 7.5 7.8 Refs
A (Rhodopsin) Adren ADA1A α1A-adren Human (-)-Adrenaline None 1 Small molecule 6.3 6.4 6.5 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR3 S1P3 Human Sphingosine 1-Phosphate None 1 Small molecule 8.4 8.6 8.6 Refs
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Cxcl6 Peptide
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM2 M2 Human Acetylcholine Principal 1 Small molecule 4.3 5.4 6.5