Data showed in this table is continously collected from the Guide to Pharmacology database. Ref
| Receptor | Endogenous ligands | pEC50 | pKi | References | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Class | Receptor family | UniProt | IUPHAR | Species | Ligand | GtP Classification |
Potency Ranking |
Type | Min | Mid | Max | Min | Mid | Max | |
| A (Rhodopsin) | Adren | ADRB1 | β1-adren | Human | (-)-Adrenaline | None | 3 | Small molecule | 5.4 | 5.7 | 6.0 | Refs | |||
| A (Rhodopsin) | Formylpeptide | FPR1 | FPR1 | Human | Fmet-Leu-Phe | None | 2 | Peptide | |||||||
| A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Rat | Srif-14 | 4 | Peptide | 8.7 | 8.9 | 8.9 | Refs | ||||
| A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Rat | Bradykinin | 4 | Peptide | 5.1 | 6.7 | 6.7 | Refs | ||||
| A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Mouse | Srif-14 | 1 | Peptide | 9.0 | 9.1 | 9.1 | 8.9 | 9.7 | 10.5 | Refs | |
| A (Rhodopsin) | Tachykinin | NK2R | NK2 | Guinea pig | Neurokinin A | Principal | 1 | Peptide | 8.9 | 8.9 | 8.0 | 8.6 | 9.1 | Refs | |
| C (Glutamate) | Calcium-sensing | CASR | CaS | Rat | Ca2+ | None | 2 | Small molecule | Refs | ||||||
| A (Rhodopsin) | Adren | ADRB3 | β3-adren | Rat | (-)-Adrenaline | None | 1 | Small molecule | |||||||
| A (Rhodopsin) | Chemerin | CML1 | hemerin | Human | 18r-Hepe | 2 | Small molecule | ||||||||
| A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Prp106-126 | None | 8 | Peptide | 4.6 | 4.6 | Refs | ||||
| A (Rhodopsin) | Free fatty acid | FFAR1 | FFA1 | Human | Myristic Acid | None | 3 | Small molecule | 4.5 | 4.8 | 5.1 | Refs | |||
| C (Glutamate) | Metabotropic glutamate | GRM5 | mGlu5 | Human | L-Glutamic Acid | Principal | 1 | Small molecule | 5.0 | 5.3 | 5.5 | Refs | |||
| A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Desulfated Gastrin-14 | 6 | Peptide | ||||||||
| A (Rhodopsin) | Neuropeptide Y | NPY2R | Y2 | Human | Peptide Yy | Secondary | 2 | Peptide | 9.5 | 9.7 | 9.8 | Refs | |||
| A (Rhodopsin) | Vasopressin and oxytocin | V1AR | V1A | Human | Vasopressin | Principal | 1 | Peptide | 8.5 | 8.4 | 8.4 | Refs | |||
| A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Human | Pgf2Α | Secondary | 2 | Small molecule | 6.2 | 6.3 | 6.3 | Refs | |||
| A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Human | Cst-17 | 2 | Peptide | 8.8 | 9.1 | 9.3 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Mouse | Pgd2 | None | 1 | Small molecule | 7.4 | 7.5 | 7.5 | Refs | |||
| A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Cxcl10 | Secondary | 2 | Peptide | |||||||
| A (Rhodopsin) | Orexin | OX1R | OX1 | Human | Orexin-A | 1 | Peptide | 6.5 | 8.4 | 10.2 | Refs | ||||
| A (Rhodopsin) | Apelin | APJ | apelin | Human | Apelin-17 | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | Class A orphan | GP139 | GPR139 | Human | L-Phenylalanine | None | 2 | Small molecule | 3.5 | 3.5 | 3.1 | 3.1 | Refs | ||
| A (Rhodopsin) | Prostanoid | PI2R | IP | Human | Pge1 | Secondary | 2 | Small molecule | 6.5 | 7.5 | 7.5 | Refs | |||
| A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Human | Pancreatic Polypeptide | Secondary | 2 | Peptide | 10.5 | 10.6 | 10.6 | Refs | |||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1F | 5-HT1F | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 7.7 | 7.9 | 8.0 | Refs | |||
| B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Rat | Vip | Principal | 1 | Peptide | 7.9 | 9.0 | 10.0 | 8.5 | 9.2 | 9.8 | Refs |
| B1 (Secretin) | Glucagon receptor family | SCTR | secretin | Rat | Vip | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl3 | Secondary | 2 | Peptide | |||||||
| A (Rhodopsin) | Vasopressin and oxytocin | V1BR | V1B | Human | Vasopressin | Principal | 1 | Peptide | 9.0 | 9.9 | 9.9 | Refs | |||
| A (Rhodopsin) | Opioid | OPRK | κ | Mouse | Dynorphin B | 5 | Peptide | 8.1 | 9.0 | 9.9 | Refs | ||||
| A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Rat | Srif-28 | 3 | Peptide | 9.8 | 9.0 | 9.0 | Refs | ||||
| A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Human | Cortistatin-14 | 1 | Peptide | 9.1 | 9.5 | 9.9 | Refs | ||||
| A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Rat | [Des-Arg10]Kallidin | 2 | Peptide | 8.7 | 8.8 | 8.8 | Refs | ||||
| A (Rhodopsin) | Peptide P518 | QRFPR | QRFP | Mouse | Qrfp43 (43rfa) | 3 | Peptide | 6.9 | 7.8 | 8.6 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Human | Pge2 | Principal | 1 | Small molecule | 6.1 | 6.1 | 8.5 | 9.0 | 9.0 | Refs | |
| A (Rhodopsin) | Prostanoid | PI2R | IP | Human | Pgi2 | Principal | 1 | Small molecule | 7.8 | 7.8 | Refs | ||||
| A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Mouse | Β-Phenylethylamine | None | 3 | Small molecule | 6.4 | 6.5 | 6.6 | Refs | |||
| A (Rhodopsin) | Neurotensin | NTR1 | NTS1 | Human | Neuromedin N | 3 | Peptide | ||||||||
| A (Rhodopsin) | Bradykinin | BKRB2 | B2 | Human | Bradykinin | 1 | Peptide | Refs | |||||||
| A (Rhodopsin) | Prostanoid | PF2R | FP | Human | Pge2 | Secondary | 2 | Small molecule | 6.4 | 7.0 | 7.0 | Refs | |||
| A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl5 | Secondary | 2 | Peptide | 8.5 | 8.9 | 9.3 | Refs | |||
| A (Rhodopsin) | Adren | ADA1D | α1D-adren | Rat | (-)-Adrenaline | None | 2 | Small molecule | 6.3 | 6.3 | Refs | ||||
| A (Rhodopsin) | Vasopressin and oxytocin | V1BR | V1B | Rat | Vasopressin | Principal | 1 | Peptide | 9.0 | 9.9 | 9.9 | Refs | |||
| A (Rhodopsin) | Chemokine | ACKR2 | ACKR2 | Human | Ccl22 | Peptide | |||||||||
| A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Neuropeptide W-30 | 5 | Peptide | ||||||||
| A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Mouse | Srif-28 | 2 | Peptide | 8.4 | 9.3 | 10.2 | Refs | ||||
| A (Rhodopsin) | Class A orphan | LGR4 | LGR4 | Human | R-Spondin-2 | 1 | Peptide | 12.5 | 12.5 | Refs | |||||
| A (Rhodopsin) | Prostanoid | PD2R | DP1 | Human | Pgd2 | Principal | 1 | Small molecule | 7.8 | 7.7 | 7.7 | Refs | |||
| B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Rat | Pacap-38 | Principal | 1 | Peptide | 9.5 | 9.8 | 10.0 | 6.9 | 8.2 | 9.0 | Refs |
| A (Rhodopsin) | Apelin | APJ | apelin | Human | Apelin-13 | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Human | Pge1 | Secondary | 2 | Small molecule | 7.0 | 7.0 | Refs | ||||
| A (Rhodopsin) | Galanin | GALR1 | GAL1 | Human | Galanin | 2 | Peptide | 9.2 | 9.6 | 9.9 | Refs | ||||
| A (Rhodopsin) | Class A orphan | GPR17 | GPR17 | Mouse | Udp-Glucose | None | 4 | Small molecule | 5.9 | 7.7 | 9.5 | Refs | |||
| A (Rhodopsin) | Somatostatin | SSR4 | SST4 | Human | Srif-14 | 2 | Peptide | 8.4 | 8.9 | 9.3 | Refs | ||||
| A (Rhodopsin) | Hydroxycarboxylic acid | HCAR1 | HCA1 | Mouse | L-Lactic Acid | Proposed | 1 | Small molecule | 1.3 | 2.1 | 2.9 | Refs | |||
| A (Rhodopsin) | Relaxin family peptide | RL3R1 | RXFP3 | Human | Relaxin-3 | 1 | Peptide | 8.3 | 9.1 | 9.9 | 7.8 | 8.4 | 8.9 | Refs | |
| A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Human | Uridine Diphosphate | None | 3 | Small molecule | 7.1 | 7.1 | Refs | ||||
| A (Rhodopsin) | Dopamine | DRD2 | D2 | Rat | Dopamine | Principal | 1 | Small molecule | 5.3 | 5.9 | 6.4 | Refs | |||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT4R | 5-HT4 | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.7 | 7.5 | 8.2 | Refs | |||
| A (Rhodopsin) | Lysophospholipid (S1P) | S1PR4 | S1P4 | Mouse | Sphingosine 1-Phosphate | None | 1 | Small molecule | 7.2 | 7.1 | 7.1 | Refs | |||
| A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Mouse | Pge1 | Secondary | 2 | Small molecule | 8.0 | 8.0 | Refs | ||||
| A (Rhodopsin) | Neurotensin | NTR2 | NTS2 | Rat | Neurotensin | 1 | Peptide | 8.8 | 8.8 | Refs | |||||
| A (Rhodopsin) | P2Y | P2RY4 | P2Y4 | Human | Atp | None | 2 | Small molecule | 5.7 | 5.4 | 5.4 | Refs | |||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT7R | 5-HT7 | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 8.1 | 8.9 | 9.6 | Refs | |||
| A (Rhodopsin) | Vasopressin and oxytocin | V2R | V2 | Human | Vasopressin | Principal | 1 | Peptide | 7.9 | 8.5 | 9.1 | Refs | |||
| A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl28 | Secondary | 2 | Peptide | |||||||
| B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Human | Vip | Principal | 1 | Peptide | 7.3 | 8.3 | 9.3 | 7.8 | 8.4 | 8.8 | Refs |
| B1 (Secretin) | Calcitonin | CALCR | CT | Human | Calcitonin | Principal | 1 | Peptide | 9.0 | 10.1 | 11.2 | Refs | |||
| A (Rhodopsin) | Relaxin family peptide | RL3R2 | RXFP4 | Human | Relaxin-3 | 1 | Peptide | 8.7 | 9.2 | 9.7 | 8.8 | 8.9 | 9.0 | Refs | |
| A (Rhodopsin) | Cholecystokinin | CCKAR | CCK1 | Human | Cck-4 | 2 | Peptide | ||||||||
| A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Human | Srif-28 | 3 | Peptide | 9.8 | 9.0 | 9.0 | Refs | ||||
| A (Rhodopsin) | Formylpeptide | FPR1 | FPR1 | Human | Annexin I | 2 | Peptide | ||||||||
| A (Rhodopsin) | Dopamine | DRD1 | D1 | Human | (-)-Noradrenaline | None | 3 | Small molecule | |||||||
| A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Human | Pge1 | Secondary | 2 | Small molecule | 8.0 | 8.0 | Refs | ||||
| A (Rhodopsin) | Ghrelin | GHSR | ghrelin | Human | [Des-Gln14]Ghrelin | 2 | Peptide | ||||||||
| A (Rhodopsin) | Free fatty acid | FFAR2 | FFA2 | Human | Acetic Acid | None | 2 | Small molecule | 3.1 | 3.9 | 4.6 | Refs | |||
| A (Rhodopsin) | Cholecystokinin | CCKAR | CCK1 | Human | Cck-33 | 2 | Peptide | ||||||||
| A (Rhodopsin) | Galanin | GALR1 | GAL1 | Rat | Galanin | 1 | Peptide | 9.8 | 9.8 | 9.3 | 9.8 | 10.3 | Refs | ||
| B1 (Secretin) | Corticotropin-releasing factor | CRFR1 | CRF1 | Human | Urocortin 1 | 1 | Peptide | Refs | |||||||
| A (Rhodopsin) | Gonadotrophin-releasing hormone | GNRHR | GnRH1 | Mouse | Gnrh I | 1 | Peptide | 7.8 | 7.9 | 7.9 | 7.3 | 8.0 | 8.4 | Refs | |
| A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Rat | Kallidin | 3 | Peptide | 7.0 | 8.0 | 8.9 | Refs | ||||
| A (Rhodopsin) | Ghrelin | GHSR | ghrelin | Human | Ghrelin | 1 | Peptide | 7.2 | 8.1 | 9.5 | 7.8 | 8.0 | 8.1 | Refs | |
| A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl26 | Principal | 1 | Peptide | Refs | ||||||
| A (Rhodopsin) | Tachykinin | NK2R | NK2 | Human | Neurokinin A | Principal | 1 | Peptide | 8.9 | 8.9 | 8.0 | 8.6 | 9.1 | Refs | |
| A (Rhodopsin) | Chemokine | ACKR1 | ACKR1 | Human | Cxcl5 | Peptide | |||||||||
| A (Rhodopsin) | GPR18, GPR55 and GPR119 | GPR55 | GPR55 | Human | N-Palmitoylethanolamine | None | 2 | Small molecule | 8.4 | 8.4 | Refs | ||||
| A (Rhodopsin) | Chemokine | CCR6 | CCR6 | Human | Ccl20 | 1 | Peptide | Refs | |||||||
| A (Rhodopsin) | Vasopressin and oxytocin | V2R | V2 | Human | Oxytocin | Secondary | 2 | Peptide | 5.4 | 6.1 | 6.8 | Refs | |||
| A (Rhodopsin) | Chemokine | CX3C1 | CX3CR1 | Human | Cx3Cl1 | Principal | 1 | Peptide | |||||||
| A (Rhodopsin) | Chemokine | CXCR2 | CXCR2 | Human | Cxcl8 | 2 | Peptide | 8.8 | 6.4 | 6.4 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Mouse | Pge2 | Principal | 1 | Small molecule | 6.1 | 6.1 | 8.5 | 9.0 | 9.0 | Refs | |
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT2C | 5-HT2C | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.7 | 7.3 | 7.9 | Refs | |||
| A (Rhodopsin) | Neurotensin | NTR1 | NTS1 | Human | Large Neuromedin N | 3 | Peptide | Refs | |||||||
| A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Mouse | Pgf2Α | Secondary | 2 | Small molecule | 8.4 | 8.4 | 6.7 | 6.7 | Refs | ||
| A (Rhodopsin) | GPR18, GPR55 and GPR119 | GPR55 | GPR55 | Human | 2-Arachidonoylglycerolphosphoinositol | None | 5 | Small molecule | Refs | ||||||
| A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Mouse | Pge2 | Principal | 1 | Small molecule | 9.4 | 9.4 | 9.0 | 9.0 | Refs | ||
| A (Rhodopsin) | Galanin | GALR2 | GAL2 | Rat | Galanin | 1 | Peptide | 7.9 | 8.5 | 9.1 | 8.6 | 8.9 | 9.1 | Refs | |
| A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Rat | Pge2 | Principal | 1 | Small molecule | 9.4 | 9.4 | 9.0 | 9.0 | Refs | ||
| A (Rhodopsin) | Leukotriene | OXER1 | OXE | Human | 5-Oxo-20-Hete | None | 6 | Small molecule | 6.5 | 6.5 | Refs | ||||
| A (Rhodopsin) | Somatostatin | SSR4 | SST4 | Rat | Srif-14 | 2 | Peptide | 8.4 | 8.9 | 9.3 | Refs | ||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT5A | 5-HT5A | Rat | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.7 | 6.6 | 6.6 | Refs | |||
| A (Rhodopsin) | Formylpeptide | FPR1 | FPR1 | Human | Cathepsin G | 2 | Peptide | ||||||||
| A (Rhodopsin) | Leukotriene | LT4R2 | BLT2 | Human | 12-Hydroxyheptadecatrienoic Acid | None | 1 | Small molecule | 7.7 | 7.7 | Refs | ||||
| B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Human | Pacap-27 | Principal | 1 | Peptide | 7.4 | 8.9 | 10.6 | 6.9 | 8.0 | 8.5 | Refs |
| A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Des-Br-Neuropeptide B-23 | 4 | Peptide | Refs | |||||||
| A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Neuropeptide B-29 | 5 | Peptide | ||||||||
| A (Rhodopsin) | Neurotensin | NTR1 | NTS1 | Rat | Neurotensin | 1 | Peptide | 8.3 | 9.0 | 9.7 | Refs | ||||
| C (Glutamate) | Metabotropic glutamate | GRM1 | mGlu1 | Human | L-Glutamic Acid | Principal | 1 | Small molecule | 4.8 | 4.9 | 5.0 | 6.4 | 6.5 | 6.5 | Refs |
| A (Rhodopsin) | Gonadotrophin-releasing hormone | GNRHR | GnRH1 | Rat | Gnrh I | 1 | Peptide | 7.8 | 7.9 | 7.9 | 7.3 | 8.0 | 8.4 | Refs | |
| A (Rhodopsin) | Tachykinin | NK3R | NK3 | Human | Substance P | 3 | Peptide | 5.0 | 5.5 | 6.0 | Refs | ||||
| B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Human | Pacap-38 | Principal | 1 | Peptide | 9.5 | 9.8 | 10.0 | 6.9 | 8.2 | 9.0 | Refs |
| A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Human | Tyramine | None | 2 | Small molecule | 6.2 | 6.7 | 7.1 | 6.4 | 6.4 | Refs | |
| A (Rhodopsin) | Chemokine | CX3C1 | CX3CR1 | Human | Cx3Cl1 | Principal | 1 | Peptide | Refs | ||||||
| A (Rhodopsin) | Melanocortin | MSHR | MC1 | Mouse | Agouti | Secondary | 2 | Peptide | Refs | ||||||
| A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Rat | Udp-Galactose | None | 4 | Small molecule | 7.0 | 7.0 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Mouse | Pge2 | None | 5 | Small molecule | 5.5 | 5.5 | Refs | ||||
| B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Human | Vip | Principal | 1 | Peptide | 7.9 | 9.0 | 10.0 | 8.5 | 9.2 | 9.8 | Refs |
| A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Rat | Peptide Yy | Principal | 1 | Peptide | 6.3 | 7.0 | 8.5 | Refs | |||
| A (Rhodopsin) | Orexin | OX1R | OX1 | Human | Orexin-B | 2 | Peptide | 5.8 | 7.5 | 9.2 | Refs | ||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT4R | 5-HT4 | Rat | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.7 | 7.5 | 8.2 | Refs | |||
| A (Rhodopsin) | Opioid | OPRK | κ | Mouse | Β-Endorphin | 7 | Peptide | 6.3 | 6.8 | 6.8 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PI2R | IP | Mouse | Pge1 | Secondary | 2 | Small molecule | 6.5 | 7.5 | 7.5 | Refs | |||
| A (Rhodopsin) | Somatostatin | SSR4 | SST4 | Human | Srif-28 | 4 | Peptide | 8.1 | 8.7 | 9.2 | Refs | ||||
| A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Human | Udp-Glucuronic Acid | None | 2 | Small molecule | 7.2 | 7.2 | Refs | ||||
| A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl7 | 8 | Peptide | ||||||||
| A (Rhodopsin) | Vasopressin and oxytocin | V1AR | V1A | Human | Oxytocin | Secondary | 2 | Peptide | 6.9 | 7.6 | 8.3 | Refs | |||
| A (Rhodopsin) | Lysophospholipid (LPA) | LPAR4 | LPA4 | Mouse | Lpa | None | 1 | Small molecule | Refs | ||||||
| A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Mouse | Cst-17 | 1 | Peptide | 8.8 | 9.3 | 9.8 | Refs | ||||
| C (Glutamate) | Class C Orphan | GPC6A | GPRC6 | Human | L-Ornithine | None | 2 | Small molecule | 4.0 | 4.0 | Refs | ||||
| A (Rhodopsin) | Melanin-concentrating hormon | MCHR1 | MCH1 | Rat | Melanin-Concentrating Hormone | Principal | 1 | Peptide | 9.7 | 10.1 | 10.5 | Refs | |||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT5A | 5-HT5A | Mouse | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.7 | 6.6 | 6.6 | Refs | |||
| A (Rhodopsin) | Neurotensin | NTR1 | NTS1 | Human | Neurotensin | 1 | Peptide | 8.3 | 9.0 | 9.7 | Refs | ||||
| A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Rat | Srif-14 | 1 | Peptide | 9.0 | 9.1 | 9.1 | 8.9 | 9.7 | 10.5 | Refs | |
| A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Rat | Β-Phenylethylamine | None | 3 | Small molecule | 6.4 | 6.5 | 6.6 | Refs | |||
| A (Rhodopsin) | Orexin | OX2R | OX2 | Human | Orexin-B | 1 | Peptide | 6.5 | 8.3 | 10.0 | Refs | ||||
| A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Human | Srif-14 | 1 | Peptide | 9.0 | 9.1 | 9.1 | 8.9 | 9.7 | 10.5 | Refs | |
| A (Rhodopsin) | P2Y | P2Y11 | P2Y11 | Human | Adp | 3 | Small molecule | ||||||||
| A (Rhodopsin) | Prostanoid | PF2R | FP | Mouse | Pge2 | Secondary | 2 | Small molecule | 6.4 | 7.0 | 7.0 | Refs | |||
| A (Rhodopsin) | Tachykinin | NK1R | NK1 | Human | Neuropeptide K | 4 | Peptide | Refs | |||||||
| B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Human | Corticotrophin-Releasing Hormone | 1 | Peptide | 7.8 | 7.8 | Refs | |||||
| A (Rhodopsin) | Galanin | GALR3 | GAL3 | Rat | Galanin | 2 | Peptide | 7.3 | 7.3 | Refs | |||||
| A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl7 | 8 | Peptide | ||||||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT6R | 5-HT6 | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.8 | 7.2 | 7.5 | Refs | |||
| A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl7 | Secondary | 2 | Peptide | |||||||
| B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Human | Secretin | Secondary | 2 | Peptide | |||||||
| A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Rat | Pyy-(3-36) | Secondary | 2 | Peptide | 6.2 | 6.2 | Refs | ||||
| B1 (Secretin) | Calcitonin | CALCR | CT | Human | Α-Cgrp | Secondary | 2 | Peptide | |||||||
| A (Rhodopsin) | Bombesin | GRPR | BB2 | Human | Gastrin-Releasing Peptide | 2 | Peptide | 6.3 | 7.3 | 8.2 | Refs | ||||
| A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Rat | Udp-Glucose | None | 1 | Small molecule | 7.7 | 7.7 | Refs | ||||
| A (Rhodopsin) | Adren | ADRB3 | β3-adren | Rat | (-)-Noradrenaline | None | 2 | Small molecule | 4.7 | 4.2 | 4.2 | Refs | |||
| B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Human | Vip | Secondary | 2 | Peptide | 6.0 | 7.0 | 8.7 | 6.0 | 6.9 | 8.4 | Refs |
| A (Rhodopsin) | Lysophospholipid (LPA) | LPAR2 | LPA2 | Mouse | Lpa | None | 1 | Small molecule | 8.0 | 8.1 | 8.2 | Refs | |||
| C (Glutamate) | Calcium-sensing | CASR | CaS | Rat | Mg2+ | None | 3 | Small molecule | Refs | ||||||
| A (Rhodopsin) | Adren | ADRB3 | β3-adren | Human | (-)-Noradrenaline | None | 2 | Small molecule | 4.7 | 4.2 | 4.2 | Refs | |||
| A (Rhodopsin) | Adenosine | AA3R | A3 | Rat | Adenosine | Principal | 1 | Small molecule | 6.5 | 6.5 | Refs | ||||
| A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Mouse | Srif-28 | 3 | Peptide | 8.1 | 9.0 | 9.9 | Refs | ||||
| A (Rhodopsin) | Bombesin | GRPR | BB2 | Mouse | Gastrin-Releasing Peptide | 2 | Peptide | 6.3 | 7.3 | 8.2 | Refs | ||||
| A (Rhodopsin) | Angiotensin | AGTR1 | AT1 | Human | Angiotensin A | 1 | Peptide | 8.2 | 8.2 | 8.8 | 8.8 | Refs | |||
| B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Mouse | Urocortin 3 | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | Free fatty acid | FFAR2 | FFA2 | Human | Butyric Acid | None | 4 | Small molecule | 2.9 | 3.8 | 4.6 | Refs | |||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1B | 5-HT1B | Human | 5-Hydroxytryptamine | None | 1 | Small molecule | 7.4 | 8.2 | 9.0 | Refs | |||
| B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Rat | Urocortin 1 | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl11 | Secondary | 2 | Peptide | Refs | ||||||
| A (Rhodopsin) | Complement peptide | C3AR | C3a | Human | C5a | 2 | Peptide | ||||||||
| A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Rat | Pancreatic Polypeptide | Secondary | 2 | Peptide | 10.5 | 10.6 | 10.6 | Refs | |||
| A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Neuropeptide W-30 | 1 | Peptide | Refs | |||||||
| A (Rhodopsin) | Prolactin-releasing peptide | PRLHR | PrRP | Human | Prrp-20 | 1 | Peptide | 9.0 | 9.3 | 9.6 | Refs | ||||
| A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Aspirin-Triggered Resolvin D1 | None | 3 | Small molecule | 11.1 | 11.1 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Rat | Pge1 | Secondary | 2 | Small molecule | 7.0 | 7.0 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Mouse | Pge1 | Secondary | 2 | Small molecule | 9.5 | 9.5 | 8.7 | 8.7 | Refs | ||
| A (Rhodopsin) | Histamine | HRH4 | H4 | Human | Histamine | None | 1 | Small molecule | 7.8 | 7.4 | 7.4 | Refs | |||
| C (Glutamate) | Calcium-sensing | CASR | CaS | Human | Spermine | None | 1 | Small molecule | Refs | ||||||
| A (Rhodopsin) | Angiotensin | AGTR1 | AT1 | Human | Angiotensin Iv | 2 | Peptide | 5.9 | 5.9 | Refs | |||||
| A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Human | Kallidin | 3 | Peptide | 7.0 | 8.0 | 8.9 | Refs | ||||
| B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Human | Phm | Secondary | 2 | Peptide | |||||||
| A (Rhodopsin) | Neuromedin U | NMUR1 | NMU1 | Human | Neuromedin U-23 | 3 | Peptide | ||||||||
| B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Rat | Vip | Principal | 1 | Peptide | 7.3 | 8.3 | 9.3 | 7.8 | 8.4 | 8.8 | Refs |
| A (Rhodopsin) | Prostanoid | PF2R | FP | Human | Pgi2 | Secondary | 2 | Small molecule | |||||||
| A (Rhodopsin) | Adren | ADRB2 | β2-adren | Human | Zn2+ | None | 4 | Small molecule | 3.3 | 4.3 | 5.3 | Refs | |||
| C (Glutamate) | Metabotropic glutamate | GRM6 | mGlu6 | Human | L-Glutamic Acid | None | 2 | Small molecule | 4.8 | 4.4 | 4.4 | Refs | |||
| A (Rhodopsin) | P2Y | P2RY1 | P2Y1 | Human | Atp | None | 1 | Small molecule | 4.8 | 4.8 | Refs | ||||
| A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Mouse | Srif-14 | 4 | Peptide | 8.7 | 8.9 | 8.9 | Refs | ||||
| A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Neuropeptide W-30 | 5 | Peptide | ||||||||
| A (Rhodopsin) | Lysophospholipid (LPA) | LPAR2 | LPA2 | Human | Lpa | None | 1 | Small molecule | 8.0 | 8.1 | 8.2 | Refs | |||
| A (Rhodopsin) | P2Y | P2Y11 | P2Y11 | Human | Atp | None | 2 | Small molecule | 4.2 | 4.9 | 5.6 | Refs | |||
| A (Rhodopsin) | Relaxin family peptide | RL3R2 | RXFP4 | Human | Insl5 | 3 | Peptide | 7.0 | 7.7 | 8.9 | 7.3 | 8.1 | 8.8 | Refs | |
| A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl13 | Secondary | 2 | Peptide | Refs | ||||||
| A (Rhodopsin) | Cannabinoid | CNR2 | CB2 | Human | Anandamide | None | 2 | Small molecule | 5.7 | 6.1 | 6.4 | Refs | |||
| A (Rhodopsin) | Leukotriene | CLTR1 | CysLT1 | Human | Ltc4 | None | 2 | Small molecule | 7.4 | 7.6 | 7.7 | 7.0 | 7.6 | 8.1 | Refs |
| A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Desulfated Cholecystokinin-8 | None | 3 | Peptide | Refs | ||||||
| C (Glutamate) | Metabotropic glutamate | GRM2 | mGlu2 | Human | L-Glutamic Acid | Principal | 1 | Small molecule | 4.7 | 5.1 | 5.4 | 5.4 | 5.7 | 5.9 | Refs |
| A (Rhodopsin) | Chemokine | ACKR2 | ACKR2 | Human | Ccl13 | Peptide | |||||||||
| A (Rhodopsin) | Class A orphan | GP183 | GPR183 | Human | 7Α,27-Dihydroxycholesterol | None | 2 | Small molecule | 8.9 | 8.9 | Refs | ||||
| A (Rhodopsin) | Class A orphan | GPR17 | GPR17 | Human | Ltd4 | None | 3 | Small molecule | 8.1 | 8.3 | 8.4 | Refs | |||
| A (Rhodopsin) | Lysophospholipid (LPA) | LPAR6 | LPA6 | Mouse | Lpa | Principal | 1 | Small molecule | 6.0 | 6.0 | Refs | ||||
| A (Rhodopsin) | Neuropeptide S | NPSR1 | NPS | Human | Neuropeptide S | Principal | 1 | Peptide | 7.3 | 7.7 | 8.0 | Refs | |||
| A (Rhodopsin) | Galanin | GALR2 | GAL2 | Human | Spexin-1 | 3 | Peptide | 6.8 | 6.8 | Refs | |||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT2C | 5-HT2C | Rat | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.7 | 7.3 | 7.9 | Refs | |||
| A (Rhodopsin) | Adenosine | AA2AR | A2A | Human | Adenosine | Principal | 1 | Small molecule | 6.5 | 6.5 | Refs | ||||
| A (Rhodopsin) | Free fatty acid | FFAR4 | FFA4 | Human | Oleic Acid | None | 4 | Small molecule | 4.7 | 4.7 | Refs | ||||
| B1 (Secretin) | Glucagon receptor family | GIPR | GIP | Rat | Gastric Inhibitory Polypeptide | Principal | 1 | Peptide | 9.1 | 9.1 | Refs | ||||
| A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl3 | Secondary | 2 | Peptide | 7.8 | 9.0 | 10.2 | Refs | |||
| A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Mouse | Srif-28 | 3 | Peptide | 9.8 | 9.0 | 9.0 | Refs | ||||
| A (Rhodopsin) | Galanin | GALR2 | GAL2 | Human | Galanin | 1 | Peptide | 7.9 | 8.5 | 9.1 | 8.6 | 8.9 | 9.1 | Refs | |
| A (Rhodopsin) | Cholecystokinin | CCKAR | CCK1 | Human | Cck-8 | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl7 | Secondary | 2 | Peptide | |||||||
| A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl5 | Secondary | 2 | Peptide | 6.8 | 7.5 | 8.2 | Refs | |||
| A (Rhodopsin) | Opioid | OPRX | NOP | Human | Nociceptin/Orphanin Fq | Principal | 1 | Peptide | 8.4 | 9.1 | 9.8 | 9.7 | 9.4 | 9.4 | Refs |
| A (Rhodopsin) | Chemokine | CXCR5 | CXCR5 | Human | Cxcl13 | Principal | 1 | Peptide | |||||||
| A (Rhodopsin) | Chemerin | CML1 | hemerin | Human | Resolvin E1 | None | 2 | Small molecule | Refs | ||||||
| B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Rat | Vip | Secondary | 2 | Peptide | 6.0 | 7.0 | 8.7 | 6.0 | 6.9 | 8.4 | Refs |
| A (Rhodopsin) | Somatostatin | SSR1 | SST1 | Human | Srif-28 | 3 | Peptide | 8.6 | 9.0 | 9.4 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Rat | Pgd2 | Secondary | 2 | Small molecule | 5.3 | 5.3 | Refs | ||||
| A (Rhodopsin) | Formylpeptide | FPR1 | FPR1 | Human | Cathepsin G | 2 | Peptide | ||||||||
| A (Rhodopsin) | Lysophospholipid (LPA) | LPAR5 | LPA5 | Human | N-Arachidonoylglycine | None | 4 | Small molecule | 4.3 | 4.3 | Refs | ||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT4R | 5-HT4 | Mouse | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.7 | 7.5 | 8.2 | Refs | |||
| A (Rhodopsin) | Lysophospholipid (LPA) | LPAR2 | LPA2 | Human | Farnesyl Diphosphate | None | 2 | Small molecule | Refs | ||||||
| A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Human | Srif-14 | 4 | Peptide | 7.7 | 8.4 | 9.1 | Refs | ||||
| A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Human | Neuropeptide Y | Secondary | 2 | Peptide | 6.4 | 7.2 | 8.8 | Refs | |||
| A (Rhodopsin) | Orexin | OX2R | OX2 | Human | Orexin-A | 1 | Peptide | 6.5 | 8.3 | 10.0 | Refs | ||||
| A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl7 | Secondary | 2 | Peptide | Refs | ||||||
| A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Human | Pge1 | Secondary | 2 | Small molecule | 9.5 | 9.5 | 8.7 | 8.7 | Refs | ||
| A (Rhodopsin) | Galanin | GALR3 | GAL3 | Human | Galanin | 2 | Peptide | 8.1 | 8.5 | 8.8 | Refs | ||||
| C (Glutamate) | Metabotropic glutamate | GRM4 | mGlu4 | Human | L-Serine-O-Phosphate | None | 1 | Small molecule | 5.9 | 5.9 | Refs | ||||
| A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Mouse | Pancreatic Polypeptide | Secondary | 2 | Peptide | 10.3 | 10.7 | 10.7 | Refs | |||
| A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Humanin | 6 | Peptide | 6.0 | 6.5 | 7.0 | Refs | ||||
| B1 (Secretin) | Parathyroid hormone | PTH2R | PTH2 | Rat | Pthrp-(1-34) (Human) | None | 2 | Peptide | Refs | ||||||
| A (Rhodopsin) | Urotensin | UR2R | UT | Mouse | Urotensin-Ii | 2 | Peptide | 8.2 | 8.6 | 9.0 | Refs | ||||
| A (Rhodopsin) | Opioid | OPRK | κ | Rat | Dynorphin A-(1-13) | 2 | Peptide | 9.3 | 10.0 | 10.7 | Refs | ||||
| A (Rhodopsin) | Acetylcholine receptors (muscarinic) | ACM3 | M3 | Human | Acetylcholine | Principal | 1 | Small molecule | 4.5 | 5.0 | 5.4 | Refs | |||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1B | 5-HT1B | Mouse | 5-Hydroxytryptamine | None | 1 | Small molecule | 7.4 | 8.2 | 9.0 | Refs | |||
| A (Rhodopsin) | Neuromedin U | NMUR2 | NMU2 | Human | Neuromedin U-25 | 2 | Peptide | 8.4 | 8.9 | 9.4 | 9.6 | 9.6 | Refs | ||
| A (Rhodopsin) | Vasopressin and oxytocin | V1AR | V1A | Rat | Vasopressin | Principal | 1 | Peptide | 8.5 | 8.4 | 8.4 | Refs | |||
| A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Human | Pgd2 | Secondary | 2 | Small molecule | 5.2 | 5.2 | Refs | ||||
| A (Rhodopsin) | Melanocortin | MC4R | MC4 | Human | Α-Msh | Secondary | 2 | Peptide | 7.4 | 7.7 | 8.0 | ||||