Data showed in this table is continously collected from the Guide to Pharmacology database. Ref
| RECEPTOR | ENDOGENOUS LIGANDS | pEC50 | pKi | REFERENCES | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Class | Receptor family | UniProt | IUPHAR | Species | Ligand | GtP Classification |
Potency Ranking |
Type | Min | Mid | Max | Min | Mid | Max | |
| A (Rhodopsin) | Opioid | OPRK | κ | Human | Α-Neoendorphin | 4 | Peptide | 8.9 | 9.5 | 10.0 | Refs | ||||
| A (Rhodopsin) | Vasopressin and oxytocin | V1BR | V1B | Human | Vasopressin | 1 | Peptide | 9.0 | 9.3 | 9.5 | Refs | ||||
| A (Rhodopsin) | Relaxin family peptide | RXFP2 | RXFP2 | Human | Relaxin-1 | 2 | Peptide | 8.8 | 8.8 | Refs | |||||
| A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl7 | 3 | Peptide | 8.1 | 8.1 | Refs | |||||
| C (Glutamate) | Calcium-sensing | CASR | CaS | Mouse | Ca2+ | None | 2 | Small molecule | Refs | ||||||
| A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Human | Pge2 | None | 1 | Small molecule | 7.3 | 7.7 | 7.7 | Refs | |||
| A (Rhodopsin) | Neuropeptide Y | NPY5R | Y5 | Human | Peptide Yy | 6 | Peptide | ||||||||
| A (Rhodopsin) | Apelin | APJ | apelin | Human | Elabela/Toddler-32 | 2 | Peptide | ||||||||
| A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl4 | 8 | Peptide | ||||||||
| A (Rhodopsin) | Histamine | HRH3 | H3 | Rat | Histamine | Principal | 1 | Small molecule | 7.8 | 8.1 | 8.3 | Refs | |||
| A (Rhodopsin) | Class A orphan | GPR35 | GPR35 | Human | Kynurenic Acid | Principal | 1 | Small molecule | 3.9 | 5.0 | 5.0 | Refs | |||
| A (Rhodopsin) | Melanocortin | MC5R | MC5 | Human | Agouti-Related Protein | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | Melatonin | MTR1A | MT1 | Human | Melatonin | Principal | 1 | Small molecule | 9.1 | 9.4 | 9.7 | Refs | |||
| A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Rat | Srif-14 | 3 | Peptide | 8.7 | 8.9 | 8.9 | Refs | ||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT2C | 5-HT2C | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.8 | 7.7 | 8.6 | Refs | |||
| A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Rat | Srif-28 | 2 | Peptide | 8.4 | 9.3 | 10.2 | Refs | ||||
| B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Rat | Pacap-27 | 2 | Peptide | 7.6 | 8.5 | 9.4 | Refs | ||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT6R | 5-HT6 | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.6 | 7.3 | 7.9 | Refs | |||
| A (Rhodopsin) | Acetylcholine receptors (muscarinic) | ACM3 | M3 | Rat | Acetylcholine | Principal | 1 | Small molecule | 4.5 | 5.0 | 5.4 | Refs | |||
| A (Rhodopsin) | Chemokine | CXCR1 | CXCR1 | Human | Cxcl8 | 1 | Peptide | 8.8 | 9.2 | 9.5 | Refs | ||||
| A (Rhodopsin) | Motilin | MTLR | motilin | Human | Motilin | Principal | 1 | Peptide | 8.4 | 8.6 | 8.7 | Refs | |||
| A (Rhodopsin) | Vasopressin and oxytocin | V1AR | V1A | Rat | Oxytocin | 2 | Peptide | 6.9 | 6.1 | 6.1 | Refs | ||||
| A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Human | Udp-Glucose | None | 1 | Small molecule | 7.7 | 7.7 | Refs | ||||
| A (Rhodopsin) | Bombesin | NMBR | BB1 | Human | Neuromedin B | 1 | Peptide | 8.1 | 9.2 | 10.3 | Refs | ||||
| A (Rhodopsin) | P2Y | P2RY4 | P2Y4 | Rat | Atp | None | 2 | Small molecule | 5.7 | 6.0 | 6.3 | Refs | |||
| A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Mouse | Srif-14 | 1 | Peptide | 9.0 | 9.1 | 9.1 | 8.9 | 9.7 | 10.5 | Refs | |
| A (Rhodopsin) | Adren | ADA1B | α1B-adren | Human | (-)-Noradrenaline | None | 2 | Small molecule | 6.2 | 6.2 | Refs | ||||
| B1 (Secretin) | Parathyroid hormone | PTH1R | PTH1 | Human | Pth | 3 | Peptide | ||||||||
| A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF1 | NPFF1 | Human | Neuropeptide Af | 3 | Peptide | ||||||||
| C (Glutamate) | Calcium-sensing | CASR | CaS | Rat | Ca2+ | None | 2 | Small molecule | Refs | ||||||
| A (Rhodopsin) | Vasopressin and oxytocin | OXYR | OT | Human | Oxytocin | 1 | Peptide | 8.2 | 8.9 | 9.6 | Refs | ||||
| A (Rhodopsin) | Orexin | OX2R | OX2 | Human | Orexin-A | 1 | Peptide | 6.5 | 8.3 | 10.0 | Refs | ||||
| A (Rhodopsin) | Relaxin family peptide | RL3R2 | RXFP4 | Human | Insl5 | 3 | Peptide | 7.0 | 7.7 | 8.9 | 7.3 | 8.1 | 8.8 | Refs | |
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1B | 5-HT1B | Mouse | 5-Hydroxytryptamine | None | 1 | Small molecule | 7.4 | 8.2 | 9.0 | Refs | |||
| A (Rhodopsin) | Lysophospholipid (S1P) | S1PR5 | S1P5 | Mouse | Sphingosine 1-Phosphate | None | 1 | Small molecule | 7.8 | 7.9 | 7.9 | Refs | |||
| A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Human | Srif-28 | 2 | Peptide | 8.1 | 9.1 | 9.1 | Refs | ||||
| A (Rhodopsin) | Kisspeptin | KISSR | kisspeptin | Human | Kisspeptin-13 | 4 | Peptide | 8.4 | 8.4 | Refs | |||||
| B1 (Secretin) | Calcitonin | CALCR | CT | Human | Calcitonin (Salmon) | None | 2 | Peptide | 7.6 | 9.4 | 11.1 | Refs | |||
| A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Human | Cst-17 | 2 | Peptide | 8.8 | 9.1 | 9.3 | Refs | ||||
| A (Rhodopsin) | Class A orphan | GPR17 | GPR17 | Mouse | Ltd4 | None | 2 | Small molecule | 8.1 | 9.2 | 9.2 | Refs | |||
| A (Rhodopsin) | Chemerin | CML1 | hemerin | Human | Resolvin E1 | None | 2 | Small molecule | Refs | ||||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT2A | 5-HT2A | Human | 5-Hydroxytryptamine | None | 2 | Small molecule | 6.0 | 6.3 | 6.5 | Refs | |||
| A (Rhodopsin) | Vasopressin and oxytocin | V1BR | V1B | Rat | Vasopressin | 1 | Peptide | 9.0 | 9.3 | 9.5 | Refs | ||||
| A (Rhodopsin) | Angiotensin | AGTR1 | AT1 | Human | Angiotensin Iv | 2 | Peptide | 5.9 | 5.9 | Refs | |||||
| A (Rhodopsin) | Adren | Q3UP63 | β3-adren | Mouse | (&Plusmn;)-Adrenaline | None | 1 | Small molecule | 3.9 | 4.3 | 4.7 | Refs | |||
| A (Rhodopsin) | Acetylcholine receptors (muscarinic) | ACM1 | M1 | Human | Acetylcholine | Principal | 1 | Small molecule | 4.3 | 5.0 | 5.0 | Refs | |||
| A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Rat | Peptide Yy | 5 | Peptide | 6.3 | 7.0 | 8.5 | Refs | ||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT7R | 5-HT7 | Rat | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 8.7 | 9.0 | 9.2 | Refs | |||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1D | 5-HT1D | Human | 5-Ht-Moduline | None | 2 | Peptide | Refs | ||||||
| A (Rhodopsin) | Adenosine | AA3R | A3 | Human | Adenosine | Principal | 1 | Small molecule | 5.2 | 5.2 | Refs | ||||
| A (Rhodopsin) | Leukotriene | OXER1 | OXE | Human | 5s-Hpete | None | 4 | Small molecule | 7.0 | 7.0 | Refs | ||||
| A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Mouse | Tyramine | None | 1 | Small molecule | 6.9 | 7.1 | 7.2 | 7.2 | 7.2 | Refs | |
| A (Rhodopsin) | Tachykinin | NK3R | NK3 | Mouse | Neurokinin B | 1 | Peptide | 8.4 | 8.4 | 8.6 | 8.7 | 8.7 | Refs | ||
| A (Rhodopsin) | Class A orphan | GPR17 | GPR17 | Mouse | Udp-Galactose | None | 4 | Small molecule | 6.0 | 7.5 | 8.9 | Refs | |||
| A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Cck-8 | 1 | Peptide | Refs | |||||||
| C (Glutamate) | Metabotropic glutamate | GRM3 | mGlu3 | Human | Naag | None | 2 | Small molecule | 4.7 | 4.7 | Refs | ||||
| A (Rhodopsin) | Bombesin | NMBR | BB1 | Human | Grp-(18-27) | 2 | Peptide | ||||||||
| A (Rhodopsin) | Class A orphan | GPR63 | GPR63 | Human | Sphingosine 1-Phosphate | None | 2 | Small molecule | 6.1 | 6.2 | 6.2 | Refs | |||
| A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl2 | 6 | Peptide | 7.5 | 7.5 | Refs | |||||
| A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Rat | Srif-14 | 1 | Peptide | 9.0 | 9.1 | 9.1 | 8.9 | 9.7 | 10.5 | Refs | |
| A (Rhodopsin) | Leukotriene | LT4R2 | BLT2 | Human | 15s-Hete | None | 2 | Small molecule | 7.5 | 7.5 | Refs | ||||
| A (Rhodopsin) | Platelet-activating factor | PTAFR | PAF | Human | Methylcarbamyl Paf | None | 2 | Small molecule | |||||||
| A (Rhodopsin) | Neuropeptide Y | NPY2R | Y2 | Human | Neuropeptide Y-(3-36) | 5 | Peptide | ||||||||
| A (Rhodopsin) | Leukotriene | OXER1 | OXE | Human | 5-Oxo-15-Hete | None | 3 | Small molecule | 7.7 | 7.7 | Refs | ||||
| A (Rhodopsin) | Opioid | OPRM | μ | Human | Dynorphin A-(1-8) | 3 | Peptide | 8.4 | 8.4 | Refs | |||||
| A (Rhodopsin) | Prostanoid | PI2R | IP | Mouse | Pge1 | None | 2 | Small molecule | 6.5 | 6.7 | 6.8 | Refs | |||
| A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Rat | Srif-14 | 3 | Peptide | 8.4 | 9.2 | 9.9 | Refs | ||||
| C (Glutamate) | Metabotropic glutamate | GRM1 | mGlu1 | Rat | L-Glutamic Acid | Principal | 1 | Small molecule | 4.8 | 4.9 | 5.0 | 6.4 | 6.5 | 6.5 | Refs |
| A (Rhodopsin) | Opioid | OPRK | κ | Mouse | Dynorphin A | 2 | Peptide | 8.3 | 9.6 | 10.8 | Refs | ||||
| A (Rhodopsin) | Cholecystokinin | CCKAR | CCK1 | Human | Desulfated Cholecystokinin-8 | 2 | Peptide | ||||||||
| A (Rhodopsin) | P2Y | P2Y12 | P2Y12 | Human | Atp | 2 | Small molecule | ||||||||
| A (Rhodopsin) | Neuropeptide Y | NPY5R | Y5 | Human | Neuropeptide Y | 1 | Peptide | 9.1 | 9.1 | Refs | |||||
| A (Rhodopsin) | Opioid | OPRK | κ | Rat | Dynorphin A | 2 | Peptide | 8.3 | 9.6 | 10.8 | Refs | ||||
| A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Mouse | Srif-28 | 2 | Peptide | 8.4 | 9.3 | 10.2 | Refs | ||||
| A (Rhodopsin) | Orexin | OX1R | OX1 | Human | Orexin-A | 1 | Peptide | 6.5 | 8.4 | 10.2 | Refs | ||||
| A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl26 | 5 | Peptide | Refs | |||||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT5A | 5-HT5A | Mouse | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.7 | 6.8 | 6.9 | Refs | |||
| A (Rhodopsin) | Prostanoid | PD2R | DP1 | Human | Pge2 | None | 4 | Small molecule | 6.5 | 6.8 | 7.0 | Refs | |||
| A (Rhodopsin) | Chemokine | ACKR4 | ACKR4 | Human | Ccl19 | 1 | Peptide | 8.5 | 8.8 | 9.1 | 8.4 | 8.4 | Refs | ||
| A (Rhodopsin) | Glycoprotein hormone | TSHR | TSH | Human | Tsh | Principal | 1 | Peptide | |||||||
| A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Human | Pgd2 | None | 2 | Small molecule | 8.8 | 8.8 | 8.7 | 5.9 | 5.9 | Refs | |
| A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Human | Pge1 | None | 1 | Small molecule | 9.4 | 9.4 | 9.0 | 9.0 | Refs | ||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT2C | 5-HT2C | Rat | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.8 | 7.7 | 8.6 | Refs | |||
| C (Glutamate) | Metabotropic glutamate | GRM4 | mGlu4 | Rat | L-Serine-O-Phosphate | None | 1 | Small molecule | 5.9 | 5.9 | Refs | ||||
| B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Human | Corticotrophin-Releasing Hormone | 1 | Peptide | 7.8 | 7.8 | Refs | |||||
| A (Rhodopsin) | Bradykinin | BKRB2 | B2 | Human | Kallidin | 1 | Peptide | Refs | |||||||
| A (Rhodopsin) | Histamine | HRH4 | H4 | Human | Histamine | None | 1 | Small molecule | 7.8 | 7.4 | 7.4 | Refs | |||
| B2 (Adhesion) | ADGRL | AGRL1 | ADGRL1 | Human | Lasso D | Principal | 1 | Peptide | |||||||
| A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Human | Pge1 | None | 1 | Small molecule | 9.5 | 9.5 | 8.7 | 8.7 | Refs | ||
| A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Prp106-126 | None | 8 | Peptide | 4.6 | 4.6 | Refs | ||||
| A (Rhodopsin) | Vasopressin and oxytocin | V1AR | V1A | Human | Vasopressin | 1 | Peptide | 8.5 | 8.9 | 9.3 | Refs | ||||
| A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Cxcl11 | 5 | Peptide | ||||||||
| C (Glutamate) | Metabotropic glutamate | GRM3 | mGlu3 | Human | L-Glutamic Acid | None | 1 | Small molecule | 5.3 | 5.4 | 5.4 | 6.4 | 6.4 | Refs | |
| A (Rhodopsin) | Neurotensin | NTR1 | NTS1 | Human | Large Neuromedin N | 3 | Peptide | Refs | |||||||
| A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl5 | 8 | Peptide | ||||||||
| A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF1 | NPFF1 | Human | Qrfp43 (43rfa) | 3 | Peptide | ||||||||
| A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Rat | Bradykinin | 4 | Peptide | 5.1 | 5.2 | 5.3 | Refs | ||||
| A (Rhodopsin) | Prostanoid | TA2R | TP | Human | Pgf2Α | None | 1 | Small molecule | 5.1 | 5.1 | Refs | ||||
| A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Rat | Pancreatic Polypeptide | 1 | Peptide | 10.3 | 10.6 | 10.8 | Refs | ||||
| A (Rhodopsin) | Class A orphan | P2Y10 | P2RY10 | Human | Lpa | None | 2 | Small molecule | 6.9 | 6.9 | Refs | ||||
| A (Rhodopsin) | Vasopressin and oxytocin | OXYR | OT | Human | Vasopressin | 2 | Peptide | 7.3 | 8.3 | 9.3 | Refs | ||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1B | 5-HT1B | Human | 5-Hydroxytryptamine | None | 1 | Small molecule | 7.4 | 8.2 | 9.0 | Refs | |||
| A (Rhodopsin) | Bombesin | GRPR | BB2 | Human | Neuromedin B | 2 | Peptide | 6.6 | 7.0 | 7.4 | Refs | ||||
| A (Rhodopsin) | Free fatty acid | FFAR2 | FFA2 | Human | Butyric Acid | None | 3 | Small molecule | 2.9 | 3.8 | 4.6 | Refs | |||
| A (Rhodopsin) | Tachykinin | NK2R | NK2 | Human | Neurokinin A | 1 | Peptide | 8.0 | 8.6 | 9.1 | Refs | ||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT7R | 5-HT7 | Mouse | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 8.7 | 9.0 | 9.2 | Refs | |||
| A (Rhodopsin) | Kisspeptin | KISSR | kisspeptin | Human | Kisspeptin-10 | 5 | Peptide | ||||||||
| A (Rhodopsin) | Urotensin | UR2R | UT | Human | Urotensin-Ii | 2 | Peptide | 8.6 | 8.6 | Refs | |||||
| A (Rhodopsin) | Opioid | OPRD | δ | Human | Β-Endorphin | 7 | Peptide | ||||||||
| A (Rhodopsin) | Galanin | GALR1 | GAL1 | Rat | Galanin | 1 | Peptide | 9.8 | 9.8 | 9.3 | 9.8 | 10.3 | Refs | ||
| A (Rhodopsin) | Galanin | GALR1 | GAL1 | Mouse | Galanin | 1 | Peptide | 9.8 | 9.8 | 9.3 | 9.8 | 10.3 | Refs | ||
| A (Rhodopsin) | Complement peptide | C3AR | C3a | Human | C3a | 2 | Peptide | ||||||||
| A (Rhodopsin) | Bombesin | NMBR | BB1 | Human | Gastrin-Releasing Peptide | 2 | Peptide | ||||||||
| A (Rhodopsin) | Histamine | HRH3 | H3 | Mouse | Histamine | Principal | 1 | Small molecule | 7.8 | 8.1 | 8.3 | Refs | |||
| A (Rhodopsin) | Lysophospholipid (S1P) | S1PR5 | S1P5 | Human | Sphingosine 1-Phosphate | None | 1 | Small molecule | 7.8 | 7.9 | 7.9 | Refs | |||
| A (Rhodopsin) | Class A orphan | GPR17 | GPR17 | Human | Ltc4 | None | 3 | Small molecule | 7.8 | 8.7 | 9.5 | Refs | |||
| C (Glutamate) | Class C Orphan | GPC6A | GPRC6 | Human | L-Serine | None | 5 | Small molecule | 3.2 | 3.2 | Refs | ||||
| A (Rhodopsin) | Vasopressin and oxytocin | V1AR | V1A | Human | Oxytocin | 2 | Peptide | 6.9 | 6.1 | 6.1 | Refs | ||||
| A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl3 | 8 | Peptide | ||||||||
| A (Rhodopsin) | Chemokine | CCR10 | CCR10 | Human | Ccl28 | Peptide | |||||||||
| A (Rhodopsin) | Prolactin-releasing peptide | PRLHR | PrRP | Human | Prrp-31 | 2 | Peptide | 9.0 | 9.1 | 9.2 | Refs | ||||
| A (Rhodopsin) | Lysophospholipid (LPA) | LPAR5 | LPA5 | Human | Farnesyl Diphosphate | None | 2 | Small molecule | 5.8 | 6.2 | 6.5 | Refs | |||
| A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Rat | Pgf2Α | None | 3 | Small molecule | 5.2 | 5.6 | 5.6 | Refs | |||
| A (Rhodopsin) | Tachykinin | NK1R | NK1 | Human | Neurokinin A | 2 | Peptide | 6.2 | 7.8 | 9.3 | Refs | ||||
| A (Rhodopsin) | Lysophospholipid (LPA) | LPAR5 | LPA5 | Human | Lpa | None | 3 | Small molecule | 4.3 | 6.1 | 7.9 | Refs | |||
| A (Rhodopsin) | Opioid | OPRK | κ | Human | Dynorphin A | 2 | Peptide | 8.3 | 9.6 | 10.8 | Refs | ||||
| A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Desulfated Gastrin-71 | 5 | Peptide | ||||||||
| A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Mouse | Srif-28 | 1 | Peptide | 9.2 | 9.8 | 10.3 | Refs | ||||
| A (Rhodopsin) | Free fatty acid | FFAR3 | FFA3 | Human | Propanoic Acid | None | 1 | Small molecule | 3.9 | 4.8 | 5.7 | Refs | |||
| A (Rhodopsin) | Adren | ADA2C | α2C-adren | Human | (-)-Noradrenaline | None | 1 | Small molecule | 5.7 | 6.3 | 6.8 | Refs | |||
| A (Rhodopsin) | Class A orphan | LGR6 | LGR6 | Human | R-Spondin-3 | Peptide | Refs | ||||||||
| A (Rhodopsin) | Gonadotrophin-releasing hormone | GNRHR | GnRH1 | Human | Gnrh I | 1 | Peptide | 7.8 | 7.9 | 7.9 | 7.3 | 8.0 | 8.4 | Refs | |
| B1 (Secretin) | Parathyroid hormone | PTH2R | PTH2 | Rat | Pthrp-(1-34) (Human) | None | 4 | Peptide | Refs | ||||||
| A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Human | Pge1 | None | 1 | Small molecule | 8.0 | 8.0 | Refs | ||||
| A (Rhodopsin) | Hydroxycarboxylic acid | HCAR3 | HCA3 | Human | 3-Hydroxyoctanoic Acid | Principal | 1 | Small molecule | 5.1 | 5.1 | Refs | ||||
| A (Rhodopsin) | Acetylcholine receptors (muscarinic) | ACM3 | M3 | Human | Acetylcholine | Principal | 1 | Small molecule | 4.5 | 5.0 | 5.4 | Refs | |||
| A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Human | Pgf2Α | None | 3 | Small molecule | 6.1 | 6.1 | 9.1 | 6.2 | 6.2 | Refs | |
| A (Rhodopsin) | Prostanoid | PD2R | DP1 | Human | Pgd2 | None | 2 | Small molecule | 7.8 | 8.5 | 9.2 | Refs | |||
| A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Human | Srif-14 | 3 | Peptide | 8.7 | 8.9 | 8.9 | Refs | ||||
| A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl4 | 1 | Peptide | 9.4 | 9.5 | 9.6 | Refs | ||||
| A (Rhodopsin) | Oxoglutarate | OXGR1 | xoglutarate | Human | Α-Ketoglutaric Acid | Principal | 1 | Small molecule | 3.3 | 3.9 | 4.5 | Refs | |||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT2B | 5-HT2B | Rat | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 7.9 | 8.2 | 8.4 | Refs | |||
| A (Rhodopsin) | Class A orphan | LGR4 | LGR4 | Human | R-Spondin-3 | 2 | Peptide | 10.7 | 10.7 | Refs | |||||
| A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Rat | Pge2 | None | 1 | Small molecule | 9.4 | 9.4 | 9.1 | 9.1 | Refs | ||
| A (Rhodopsin) | Class A orphan | MRGRD | MRGPRD | Human | Β-Alanine | Principal | 1 | Small molecule | 4.8 | 4.8 | Refs | ||||
| B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Rat | Vip | 1 | Peptide | 7.9 | 9.0 | 10.0 | 8.5 | 9.2 | 9.8 | Refs | |
| A (Rhodopsin) | Class A orphan | GPR12 | GPR12 | Human | Sphingosine 1-Phosphate | Principal | 1 | Small molecule | 5.5 | 6.3 | 7.0 | Refs | |||
| A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl7 | 4 | Peptide | Refs | |||||||
| A (Rhodopsin) | Opioid | OPRX | NOP | Mouse | Nociceptin/Orphanin Fq | Principal | 1 | Peptide | 8.4 | 9.1 | 9.8 | 9.7 | 9.4 | 9.4 | Refs |
| A (Rhodopsin) | Chemokine | CXCR6 | CXCR6 | Human | Cxcl16 | Principal | 1 | Peptide | Refs | ||||||
| A (Rhodopsin) | Galanin | GALR1 | GAL1 | Human | Galanin | 2 | Peptide | 9.1 | 9.8 | 10.5 | Refs | ||||
| A (Rhodopsin) | Somatostatin | SSR1 | SST1 | Human | Srif-14 | 2 | Peptide | 8.6 | 9.1 | 9.5 | Refs | ||||
| A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl8 | 3 | Peptide | Refs | |||||||
| A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Mouse | Pgf2Α | None | 3 | Small molecule | 6.2 | 6.4 | 6.4 | Refs | |||
| A (Rhodopsin) | Leukotriene | CLTR1 | CysLT1 | Human | Lte4 | None | 3 | Small molecule | 6.4 | 6.7 | 7.2 | 7.1 | 7.5 | 7.8 | Refs |
| A (Rhodopsin) | Leukotriene | CLTR2 | CysLT2 | Human | Ltc4 | None | 1 | Small molecule | 7.0 | 7.6 | 8.6 | Refs | |||
| A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Human | Kallidin | 2 | Peptide | 7.0 | 8.0 | 8.9 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Rat | Pgd2 | None | 3 | Small molecule | 7.9 | 7.9 | 5.9 | 7.4 | 8.9 | Refs | |
| B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Human | Pacap-38 | 2 | Peptide | 7.5 | 8.9 | 10.3 | 8.4 | 8.6 | 8.8 | Refs | |
| B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Rat | Vip | 3 | Peptide | 7.3 | 8.3 | 9.3 | 7.8 | 8.4 | 8.8 | Refs | |
| A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Mouse | Srif-28 | 2 | Peptide | 8.1 | 9.1 | 9.1 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Rat | Pgd2 | None | 5 | Small molecule | 4.7 | 4.7 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Mouse | Pge2 | None | 2 | Small molecule | 7.5 | 7.9 | 8.3 | Refs | |||
| A (Rhodopsin) | Neurotensin | NTR2 | NTS2 | Rat | Neurotensin | 1 | Peptide | 8.8 | 8.8 | Refs | |||||
| B1 (Secretin) | Calcitonin | CALCR | CT | Human | Amylin | 3 | Peptide | 8.0 | 8.6 | 9.2 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Mouse | Pge2 | None | 1 | Small molecule | 9.4 | 9.4 | 9.1 | 9.1 | Refs | ||
| A (Rhodopsin) | P2Y | P2Y11 | P2Y11 | Human | Uridine Triphosphate | None | 1 | Small molecule | 5.2 | 5.2 | Refs | ||||
| A (Rhodopsin) | Bombesin | GRPR | BB2 | Human | Gastrin-Releasing Peptide | 1 | Peptide | 6.3 | 7.3 | 8.2 | Refs | ||||
| A (Rhodopsin) | Bombesin | GRPR | BB2 | Mouse | Neuromedin B | 2 | Peptide | 6.6 | 7.0 | 7.4 | Refs | ||||
| B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Human | Pacap-27 | 2 | Peptide | 7.6 | 8.5 | 9.4 | Refs | ||||
| A (Rhodopsin) | Lysophospholipid (LPA) | LPAR3 | LPA3 | Human | Farnesyl Diphosphate | None | 2 | Small molecule | Refs | ||||||
| A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl2 | 1 | Peptide | Refs | |||||||
| A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Human | Srif-14 | 3 | Peptide | 8.4 | 9.2 | 9.9 | Refs | ||||
| A (Rhodopsin) | P2Y | P2RY4 | P2Y4 | Human | Uridine Triphosphate | None | 1 | Small molecule | 6.3 | 6.3 | Refs | ||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT7R | 5-HT7 | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 8.7 | 9.0 | 9.2 | Refs | |||
| A (Rhodopsin) | Free fatty acid | FFAR4 | FFA4 | Rat | Α-Linolenic Acid | None | 2 | Small molecule | 5.5 | 5.5 | Refs | ||||
| A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Rat | Pge2 | None | 3 | Small molecule | 6.1 | 6.1 | 8.1 | 9.0 | 9.0 | Refs | |
| A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Mouse | Pgd2 | None | 2 | Small molecule | 7.4 | 7.5 | 7.5 | Refs | |||
| A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Rat | Srif-28 | 1 | Peptide | 9.2 | 9.8 | 10.3 | Refs | ||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT4R | 5-HT4 | Mouse | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.7 | 7.5 | 8.2 | Refs | |||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT5A | 5-HT5A | Rat | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.7 | 6.8 | 6.9 | Refs | |||
| A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Des-Br-Neuropeptide B-23 | 4 | Peptide | Refs | |||||||
| A (Rhodopsin) | Dopamine | DRD3 | D3 | Human | Dopamine | Principal | 1 | Small molecule | 6.4 | 6.9 | 7.3 | Refs | |||
| C (Glutamate) | Class C Orphan | GPC6A | GPRC6 | Human | Glycine | None | 4 | Small molecule | 3.6 | 3.6 | Refs | ||||
| A (Rhodopsin) | Lysophospholipid (S1P) | S1PR4 | S1P4 | Human | Sphingosine 1-Phosphate | None | 1 | Small molecule | 7.2 | 7.7 | 8.1 | Refs | |||
| A (Rhodopsin) | Class A orphan | GP139 | GPR139 | Human | L-Tryptophan | None | 1 | Small molecule | 3.7 | 3.7 | 3.1 | 3.1 | Refs | ||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1F | 5-HT1F | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 7.7 | 7.9 | 8.0 | Refs | |||
| A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl2 | 5 | Peptide | ||||||||
| A (Rhodopsin) | Chemokine | CCR8 | CCR8 | Human | Ccl1 | 1 | Peptide | Refs | |||||||
| B1 (Secretin) | Parathyroid hormone | PTH1R | PTH1 | Human | Pthrp-(1-36) | 2 | Peptide | Refs | |||||||
| B1 (Secretin) | Glucagon receptor family | SCTR | secretin | Rat | Vip | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF1 | NPFF1 | Human | Neuropeptide Sf | 3 | Peptide | ||||||||
| A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Human | Pge2 | None | 3 | Small molecule | 6.1 | 6.1 | 8.1 | 9.0 | 9.0 | Refs | |
| A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Human | Neuropeptide Y | 4 | Peptide | 6.4 | 8.0 | 8.0 | Refs | ||||
| C (Glutamate) | Metabotropic glutamate | GRM6 | mGlu6 | Human | L-Glutamic Acid | None | 2 | Small molecule | 4.8 | 5.0 | 5.2 | Refs | |||
| A (Rhodopsin) | Lysophospholipid (LPA) | LPAR4 | LPA4 | Human | Farnesyl Diphosphate | None | 2 | Small molecule | Refs | ||||||
| A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF2 | NPFF2 | Human | Qrfp43 (43rfa) | 3 | Peptide | ||||||||
| A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1D | 5-HT1D | Human | 5-Hydroxytryptamine | None | 1 | Small molecule | 8.0 | 8.5 | 9.0 | Refs | |||
| B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Human | Vip | 1 | Peptide | 7.9 | 9.0 | 10.0 | 8.5 | 9.2 | 9.8 | Refs | |
| A (Rhodopsin) | Leukotriene | CLTR1 | CysLT1 | Human | Ltd4 | None | 1 | Small molecule | 7.3 | 8.6 | 9.4 | Refs | |||
| A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Human | Octopamine | None | 4 | Small molecule | |||||||
| A (Rhodopsin) | Apelin | APJ | apelin | Human | Apelin-36 | 2 | Peptide | Refs | |||||||
| A (Rhodopsin) | Cannabinoid | CNR1 | CB1 | Human | Anandamide | None | 2 | Small molecule | 6.3 | 6.7 | 7.0 | Refs | |||
| C (Glutamate) | Metabotropic glutamate | GRM2 | mGlu2 | Human | L-Glutamic Acid | Principal | 1 | Small molecule | 4.7 | 5.1 | 5.4 | 5.4 | 5.7 | 5.9 | |