CXCR1 (cxcr1_human)
FAMILY
Class A (Rhodopsin) Protein receptors Chemokine receptors CXCR1
GENE
CXCR1 (CMKAR1, IL8RA)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
C-X-C chemokine receptor type 1, CXC-R1, CXCR-1, CDw128a, High affinity interleukin-8 receptor A, IL-8R A, IL-8 receptor type 1, CD181
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
S
|
N
|
I
|
T
|
D
|
P
|
Q
|
M
|
W
|
10 |
D
|
F
|
D
|
D
|
L
|
N
|
F
|
T
|
G
|
M
|
20 |
P
|
P
|
A
|
D
|
E
|
D
|
Y
|
S
|
P
|
C
|
30 |
TM1 | |||||||||
M
|
L
|
E
|
T
|
E
|
T
|
L
|
N
|
K
|
Y
|
40 |
V
|
V
|
I
|
I
|
A
|
Y
|
A
|
L
|
V
|
F
|
50 |
L
|
L
|
S
|
L
|
L
|
G
|
N
|
S
|
L
|
V
|
60 |
M
|
L
|
V
|
I
|
L
|
Y
|
S
|
R
|
V
|
G
|
70 |
ICL1 | TM2 | ||||||||
R
|
S
|
V
|
T
|
D
|
V
|
Y
|
L
|
L
|
N
|
80 |
L
|
A
|
L
|
A
|
D
|
L
|
L
|
F
|
A
|
L
|
90 |
T
|
L
|
P
|
I
|
W
|
A
|
A
|
S
|
K
|
V
|
100 |
ECL1 | TM3 | ||||||||
N
|
G
|
W
|
I
|
F
|
G
|
T
|
F
|
L
|
C
|
110 |
K
|
V
|
V
|
S
|
L
|
L
|
K
|
E
|
V
|
N
|
120 |
F
|
Y
|
S
|
G
|
I
|
L
|
L
|
L
|
A
|
C
|
130 |
I
|
S
|
V
|
D
|
R
|
Y
|
L
|
A
|
I
|
V
|
140 |
ICL2 | |||||||||
H
|
A
|
T
|
R
|
T
|
L
|
T
|
Q
|
K
|
R
|
150 |
TM4 | |||||||||
H
|
L
|
V
|
K
|
F
|
V
|
C
|
L
|
G
|
C
|
160 |
W
|
G
|
L
|
S
|
M
|
N
|
L
|
S
|
L
|
P
|
170 |
ECL2 | |||||||||
F
|
F
|
L
|
F
|
R
|
Q
|
A
|
Y
|
H
|
P
|
180 |
N
|
N
|
S
|
S
|
P
|
V
|
C
|
Y
|
E
|
V
|
190 |
TM5 | |||||||||
L
|
G
|
N
|
D
|
T
|
A
|
K
|
W
|
R
|
M
|
200 |
V
|
L
|
R
|
I
|
L
|
P
|
H
|
T
|
F
|
G
|
210 |
F
|
I
|
V
|
P
|
L
|
F
|
V
|
M
|
L
|
F
|
220 |
C
|
Y
|
G
|
F
|
T
|
L
|
R
|
T
|
L
|
F
|
230 |
ICL3 | TM6 | ||||||||
K
|
A
|
H
|
M
|
G
|
Q
|
K
|
H
|
R
|
A
|
240 |
M
|
R
|
V
|
I
|
F
|
A
|
V
|
V
|
L
|
I
|
250 |
F
|
L
|
L
|
C
|
W
|
L
|
P
|
Y
|
N
|
L
|
260 |
V
|
L
|
L
|
A
|
D
|
T
|
L
|
M
|
R
|
T
|
270 |
ECL3 | TM7 | ||||||||
Q
|
V
|
I
|
Q
|
E
|
S
|
C
|
E
|
R
|
R
|
280 |
N
|
N
|
I
|
G
|
R
|
A
|
L
|
D
|
A
|
T
|
290 |
E
|
I
|
L
|
G
|
F
|
L
|
H
|
S
|
C
|
L
|
300 |
H8 | |||||||||
N
|
P
|
I
|
I
|
Y
|
A
|
F
|
I
|
G
|
Q
|
310 |
N
|
F
|
R
|
H
|
G
|
F
|
L
|
K
|
I
|
L
|
320 |
C-term | |||||||||
A
|
M
|
H
|
G
|
L
|
V
|
S
|
K
|
E
|
F
|
330 |
L
|
A
|
R
|
H
|
R
|
V
|
T
|
S
|
Y
|
T
|
340 |
S
|
S
|
S
|
V
|
N
|
V
|
S
|
S
|
N
|
L
|
350 |
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
CXCL8, cytokine domain of tyrosyl tRNA synthetase, CXCL6
STRUCTURE MODELS
STRUCTURES
Found 1 structure(s) - view all details on the Structures page
PDBs: 8IC0