PAR4 (par4_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Proteinase-activated receptors PAR4
GENE
F2RL3 (PAR4)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Proteinase-activated receptor 4, PAR-4, Coagulation factor II receptor-like 3, Thrombin receptor-like 3
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
W
|
G
|
R
|
L
|
L
|
L
|
W
|
P
|
L
|
10 |
V
|
L
|
G
|
F
|
S
|
L
|
S
|
G
|
G
|
T
|
20 |
Q
|
T
|
P
|
S
|
V
|
Y
|
D
|
E
|
S
|
G
|
30 |
S
|
T
|
G
|
G
|
G
|
D
|
D
|
S
|
T
|
P
|
40 |
S
|
I
|
L
|
P
|
A
|
P
|
R
|
G
|
Y
|
P
|
50 |
G
|
Q
|
V
|
C
|
A
|
N
|
D
|
S
|
D
|
T
|
60 |
L
|
E
|
L
|
P
|
D
|
S
|
S
|
R
|
A
|
L
|
70 |
TM1 | |||||||||
L
|
L
|
G
|
W
|
V
|
P
|
T
|
R
|
L
|
V
|
80 |
P
|
A
|
L
|
Y
|
G
|
L
|
V
|
L
|
V
|
V
|
90 |
G
|
L
|
P
|
A
|
N
|
G
|
L
|
A
|
L
|
W
|
100 |
ICL1 | |||||||||
V
|
L
|
A
|
T
|
Q
|
A
|
P
|
R
|
L
|
P
|
110 |
TM2 | |||||||||
S
|
T
|
M
|
L
|
L
|
M
|
N
|
L
|
A
|
A
|
120 |
A
|
D
|
L
|
L
|
L
|
A
|
L
|
A
|
L
|
P
|
130 |
P
|
R
|
I
|
A
|
Y
|
H
|
L
|
R
|
G
|
Q
|
140 |
ECL1 | TM3 | ||||||||
R
|
W
|
P
|
F
|
G
|
E
|
A
|
A
|
C
|
R
|
150 |
L
|
A
|
T
|
A
|
A
|
L
|
Y
|
G
|
H
|
M
|
160 |
Y
|
G
|
S
|
V
|
L
|
L
|
L
|
A
|
A
|
V
|
170 |
S
|
L
|
D
|
R
|
Y
|
L
|
A
|
L
|
V
|
H
|
180 |
ICL2 | |||||||||
P
|
L
|
R
|
A
|
R
|
A
|
L
|
R
|
G
|
R
|
190 |
TM4 | |||||||||
R
|
L
|
A
|
L
|
G
|
L
|
C
|
M
|
A
|
A
|
200 |
W
|
L
|
M
|
A
|
A
|
A
|
L
|
A
|
L
|
P
|
210 |
ECL2 | |||||||||
L
|
T
|
L
|
Q
|
R
|
Q
|
T
|
F
|
R
|
L
|
220 |
A
|
R
|
S
|
D
|
R
|
V
|
L
|
C
|
H
|
D
|
230 |
TM5 | |||||||||
A
|
L
|
P
|
L
|
D
|
A
|
Q
|
A
|
S
|
H
|
240 |
W
|
Q
|
P
|
A
|
F
|
T
|
C
|
L
|
A
|
L
|
250 |
L
|
G
|
C
|
F
|
L
|
P
|
L
|
L
|
A
|
M
|
260 |
L
|
L
|
C
|
Y
|
G
|
A
|
T
|
L
|
H
|
T
|
270 |
ICL3 | TM6 | |||||||||
L
|
A
|
A
|
S
|
G
|
R
|
R
|
Y
|
G
|
H
|
|
280 |
A
|
L
|
R
|
L
|
T
|
A
|
V
|
V
|
L
|
A
|
290 |
S
|
A
|
V
|
A
|
F
|
F
|
V
|
P
|
S
|
N
|
300 |
L
|
L
|
L
|
L
|
L
|
H
|
Y
|
S
|
D
|
P
|
310 |
ECL3 | TM7 | ||||||||
S
|
P
|
S
|
A
|
W
|
G
|
N
|
L
|
Y
|
G
|
320 |
A
|
Y
|
V
|
P
|
S
|
L
|
A
|
L
|
S
|
T
|
330 |
L
|
N
|
S
|
C
|
V
|
D
|
P
|
F
|
I
|
Y
|
340 |
H8 | |||||||||
Y
|
Y
|
V
|
S
|
A
|
E
|
F
|
R
|
D
|
K
|
350 |
V
|
R
|
A
|
G
|
L
|
F
|
Q
|
R
|
S
|
P
|
360 |
C-term | |||||||||
G
|
D
|
T
|
V
|
A
|
S
|
K
|
A
|
S
|
A
|
370 |
E
|
G
|
G
|
S
|
R
|
G
|
M
|
G
|
T
|
H
|
380 |
S
|
S
|
L
|
L
|
Q
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
cathepsin G, thrombin
STRUCTURE MODELS
STRUCTURES
No structures available