PAR4 - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8YRQ

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

June 10, 2026

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

No ligands

PHYSIOLOGICAL LIGANDS

cathepsin G (Rat), thrombin (Human), cathepsin G (Mouse), thrombin (Mouse), cathepsin G (Human), thrombin (Rat)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 188 - G.H5 N 347 G.H5.19
Hydrophobic TM6 L 284 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 284 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM2 S 111 2x39 G.H5 Y 351 G.H5.23
Van-der-waals TM2 S 111 2x39 G.H5 Y 351 G.H5.23
Hydrophobic ICL2 R 185 - G.S1 V 34 G.S1.02
Polar TM3 D 173 3x49 G.H5 Y 351 G.H5.23
Hydrophobic TM3 D 173 3x49 G.H5 Y 351 G.H5.23
Van-der-waals TM3 D 173 3x49 G.H5 Y 351 G.H5.23
Hydrophobic TM3 L 178 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 178 3x54 G.H5 L 348 G.H5.20
Polar ICL2 R 188 - G.H5 Y 351 G.H5.23
Hydrophobic ICL2 R 188 - G.H5 Y 351 G.H5.23
Van-der-waals ICL2 R 188 - G.H5 Y 351 G.H5.23
Hydrophobic TM3 A 177 3x53 G.H5 Y 351 G.H5.23
Van-der-waals TM3 A 177 3x53 G.H5 Y 351 G.H5.23
Hydrophobic ICL2 R 185 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 R 185 - G.H5 I 343 G.H5.15
Ionic ICL3 R 277 - G.H5 D 341 G.H5.13
Polar ICL3 R 277 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 277 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 277 - G.H5 D 341 G.H5.13
Hydrophobic TM3 R 174 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 174 3x50 G.H5 L 353 G.H5.25
Polar ICL3 Y 278 - G.H5 Q 345 G.H5.17
Hydrophobic ICL3 Y 278 - G.H5 Q 345 G.H5.17
Van-der-waals ICL3 Y 278 - G.H5 Q 345 G.H5.17
Polar TM6 H 280 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 H 280 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL4 V 343 - G.H5 N 352 G.H5.19
Hydrophobic ICL2 P 181 - G.H5 L 344 G.H5.16
Polar TM3 A 177 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 177 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 177 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM2 L 109 2x37 G.H5 E 350 G.H5.22
Van-der-waals TM2 L 109 2x37 G.H5 E 350 G.H5.22
Hydrophobic ICL2 L 182 - G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 182 - G.H5 F 336 G.H5.08
Hydrophobic TM3 L 178 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 L 178 3x54 G.H5 L 353 G.H5.25
Polar ICL2 R 185 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 L 182 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 182 - G.H5 I 343 G.H5.15
Ionic ICL2 R 188 - G.H5 E 350 G.H5.22
Polar ICL2 R 188 - G.H5 E 350 G.H5.22
Hydrophobic ICL2 R 188 - G.H5 E 350 G.H5.22
Van-der-waals ICL2 R 188 - G.H5 E 350 G.H5.22
Polar ICL3 Y 278 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 Y 278 - G.H5 D 341 G.H5.13
Van-der-waals TM3 L 178 3x54 G.H5 L 344 G.H5.16
Hydrophobic ICL2 L 182 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 L 182 - G.H5 T 340 G.H5.12
Hydrophobic TM3 R 174 3x50 G.H5 Y 351 G.H5.23
Van-der-waals TM3 R 174 3x50 G.H5 Y 351 G.H5.23
Hydrophobic ICL3 Y 278 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 Y 278 - G.H5 L 348 G.H5.20
Hydrophobic TM5 L 271 5x65 G.H5 L 344 G.H5.16
Hydrophobic TM6 A 281 6x34 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 181 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 181 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 181 - G.H5 T 340 G.H5.12
Hydrophobic TM3 L 178 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 178 3x54 G.H5 N 347 G.H5.19
Polar ICL2 R 185 - G.S1 D 33 G.S1.01
Van-der-waals ICL2 R 185 - G.S1 D 33 G.S1.01
Hydrophobic ICL3 Y 278 - G.H5 L 344 G.H5.16
Van-der-waals ICL3 Y 278 - G.H5 L 344 G.H5.16
Hydrophobic ICL2 A 186 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 A 186 - G.hns1 K 32 G.hns1.03
Hydrophobic TM5 L 271 5x65 G.H5 L 348 G.H5.20
Ionic ICL3 R 277 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 277 - G.h4s6 E 318 G.h4s6.12
Polar TM2 S 111 2x39 G.H5 E 350 G.H5.22
Hydrophobic TM2 S 111 2x39 G.H5 E 350 G.H5.22
Van-der-waals TM2 S 111 2x39 G.H5 E 350 G.H5.22
Polar ICL2 R 185 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 185 - G.hns1 A 31 G.hns1.02
Polar TM6 A 281 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 281 6x34 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 281 6x34 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 182 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 182 - G.S3 L 195 G.S3.01