H1 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7DFL

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41467-021-22427-2

PUBLICATION DATE

March 31, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

15 interactions (Click to see)

LIGANDS

histamine - Agonist pubchem gtoplig chembl_ligand drug_central drugbank gtoplig

PHYSIOLOGICAL LIGANDS

histamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic ICL2 R 139 - G.H5 E 355 G.H5.22
Polar ICL2 R 139 - G.H5 E 355 G.H5.22
Hydrophobic ICL3 L 405 - G.H5 V 359 G.H5.26
Van-der-waals ICL3 L 405 - G.H5 V 359 G.H5.26
Aromatic TM3 R 125 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 125 3x50 G.H5 Y 356 G.H5.23
Polar TM6 A 413 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 413 6x33 G.H5 L 358 G.H5.25
Polar TM6 K 412 6x32 G.H5 V 359 G.H5.26
Hydrophobic ICL2 L 133 - G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 133 - G.H5 I 348 G.H5.15
Polar ICL4 N 474 - G.H5 N 357 G.H5.24
Van-der-waals ICL2 K 137 - G.hns1 R 38 G.hns1.03
Polar TM3 S 128 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 S 128 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 S 128 3x53 G.H5 N 352 G.H5.19
Polar ICL3 Q 219 - G.H5 D 346 G.H5.13
Hydrophobic TM6 Q 416 6x36 G.H5 L 358 G.H5.25
Hydrophobic TM6 K 412 6x32 G.H5 L 358 G.H5.25
Polar TM3 D 124 3x49 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 L 136 - G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 L 136 - G.hns1 R 38 G.hns1.03
Van-der-waals ICL4 N 472 - G.H5 Y 356 G.H5.23
Hydrophobic ICL2 K 137 - G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 K 137 - G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 P 132 - G.H5 F 341 G.H5.08
Hydrophobic ICL2 Y 135 - G.S3 V 199 G.S3.01
Polar ICL4 N 472 - G.H5 N 357 G.H5.24
Van-der-waals ICL4 N 472 - G.H5 N 357 G.H5.24
Van-der-waals ICL4 N 472 - G.H5 E 355 G.H5.22
Hydrophobic TM5 V 217 5x65 G.H5 L 353 G.H5.20
Van-der-waals TM5 V 217 5x65 G.H5 L 353 G.H5.20
Hydrophobic ICL2 L 133 - G.S1 L 40 G.S1.02
Hydrophobic TM3 V 129 3x54 G.H5 L 349 G.H5.16
Hydrophobic ICL2 Y 135 - G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 Y 135 - G.s2s3 S 198 G.s2s3.02
Polar TM3 S 128 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 S 128 3x53 G.H5 Y 356 G.H5.23
Ionic ICL2 K 137 - G.HN E 28 G.HN.52
Polar ICL2 K 137 - G.HN E 28 G.HN.52
Hydrophobic ICL2 K 137 - G.HN E 28 G.HN.52
Van-der-waals ICL2 K 137 - G.HN E 28 G.HN.52
Polar TM6 K 412 6x32 G.H5 N 357 G.H5.24
Van-der-waals TM6 K 412 6x32 G.H5 N 357 G.H5.24
Hydrophobic ICL3 Q 219 - G.H5 L 349 G.H5.16
Van-der-waals ICL3 Q 219 - G.H5 L 349 G.H5.16
Polar ICL2 Y 135 - G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 Y 135 - G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 P 132 - G.H5 K 345 G.H5.12
Van-der-waals ICL2 P 132 - G.H5 K 345 G.H5.12
Hydrophobic TM3 V 129 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 V 129 3x54 G.H5 L 353 G.H5.20
Hydrophobic TM6 L 417 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM7 C 471 7x56 G.H5 N 357 G.H5.24
Van-der-waals TM7 C 471 7x56 G.H5 N 357 G.H5.24