GnRH1 receptor (gnrhr_human)

FAMILY

Class A (Rhodopsin) Peptide receptors Gonadotrophin-releasing hormone receptors GnRH1 receptor

GENE

GNRHR (GRHR)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Gonadotropin-releasing hormone receptor, GnRH receptor, GnRH-R

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
A
N
S
A
S
P
E
Q
N
10
                   
Q
N
H
C
S
A
I
N
N
S
20
                   
I
P
L
M
Q
G
N
L
P
T
30
  TM1            
L
T
L
S
G
K
I
R
V
T
40
                   
V
T
F
F
L
F
L
L
S
A
50
                   
T
F
N
A
S
F
L
L
K
L
60
      ICL1      
Q
K
W
T
Q
K
K
E
K
G
70
        TM2      
K
K
L
S
R
M
K
L
L
L
80
                   
K
H
L
T
L
A
N
L
L
E
90
                   
T
L
I
V
M
P
L
D
G
M
100
    ECL1        
W
N
I
T
V
Q
W
Y
A
G
110
TM3              
E
L
L
C
K
V
L
S
Y
L
120
                   
K
L
F
S
M
Y
A
P
A
F
130
                   
M
M
V
V
I
S
L
D
R
S
140
          ICL2  
L
A
I
T
R
P
L
A
L
K
150
  TM4            
S
N
S
K
V
G
Q
S
M
V
160
                   
G
L
A
W
I
L
S
S
V
F
170
                   
A
G
P
Q
L
Y
I
F
R
M
180
ECL2            
I
H
L
A
D
S
S
G
Q
T
190
                   
K
V
F
S
Q
C
V
T
H
C
200
      TM5        
S
F
S
Q
W
W
H
Q
A
F
210
                   
Y
N
F
F
T
F
S
C
L
F
220
                   
I
I
P
L
F
I
M
L
I
C
230
                   
N
A
K
I
I
F
T
L
T
R
240
                   
V
L
H
Q
D
P
H
E
L
Q
250
ICL3 TM6      
L
N
Q
S
K
N
N
I
P
R
260
                   
A
R
L
K
T
L
K
M
T
V
270
                   
A
F
A
T
S
F
T
V
C
W
280
                   
T
P
Y
Y
V
L
G
I
W
Y
290
      ECL3      
W
F
D
P
E
M
L
N
R
L
300
TM7              
S
D
P
V
N
H
F
F
F
L
310
                   
F
A
F
L
N
P
C
F
D
P
320
               
L
I
Y
G
Y
F
S
L

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 K T Q K K E K G K L S ICL1ECL1 I T V Q W Y A ECL1ICL2 P L A L K S ICL2ECL2 R M I H L A D S S G Q T K V F S Q C V T H C S F S ECL2ICL3 E L Q L N ICL3ECL3 P E M L N R L ECL3N-term M A N S A S P E Q N Q N H C S A I N N S I P L M Q G N L P T L N-termC-term L C-term T L S G K I R V T V T F F L F L L S A T F N A S F L L K L Q K W R M K L L L K H L T L A N L L E T L I V M P L D G M W N G E L L C K V L S Y L K L F S M Y A P A F M M V V I S L D R S L A I T R N S K V G Q S M V G L A W I L S S V F A G P Q L Y I F Q W W H Q A F Y N F F T F S C L F I I P L F I M L I C N A K I I F T L T R V L H Q D P H Q S K N N I P R A R L K T L K M T V A F A T S F T V C W T P Y Y V L G I W Y W F D S D P V N H F F F L F A F L N P C F D P L I Y G Y F S
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

A N F T A S L L F L F F T V T V R I K G 1 K H L T L A N L L E T I L V M P L D G M W 2 V V M M F A P A Y M S F L K L Y S L V K 3 G Q S M V G L A W I L S S V F A G P Q 4 N C I L M I F L P I I F L C S F T F F N Y 5 V A F A T S F T V C W T P Y Y V L G I W 6 L P D F C P N L F A F L F F F H N V P 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

286 mutation data points available.

PHYSIOLOGICAL LIGANDS

GnRH II, GnRH I

STRUCTURE MODELS

gnrhr_human inactive,

gnrhr_human active

STRUCTURES

Found 1 structure(s) - view all details on the Structures page

PDBs: 7BR3