LPA2 receptor (lpar2_human)
FAMILY
Class A (Rhodopsin) Lipid receptors Lysophospholipid (LPA) receptors LPA2 receptor
GENE
LPAR2 (EDG4, LPA2)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Lysophosphatidic acid receptor 2, LPA receptor 2, LPA-2, Lysophosphatidic acid receptor Edg-4
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
G
|
Q
|
C
|
Y
|
Y
|
N
|
E
|
T
|
I
|
10 |
G
|
F
|
F
|
Y
|
N
|
N
|
S
|
G
|
K
|
E
|
20 |
TM1 | |||||||||
L
|
S
|
S
|
H
|
W
|
R
|
P
|
K
|
D
|
V
|
30 |
V
|
V
|
V
|
A
|
L
|
G
|
L
|
T
|
V
|
S
|
40 |
V
|
L
|
V
|
L
|
L
|
T
|
N
|
L
|
L
|
V
|
50 |
I
|
A
|
A
|
I
|
A
|
S
|
N
|
R
|
R
|
F
|
60 |
ICL1 | TM2 | ||||||||
H
|
Q
|
P
|
I
|
Y
|
Y
|
L
|
L
|
G
|
N
|
70 |
L
|
A
|
A
|
A
|
D
|
L
|
F
|
A
|
G
|
V
|
80 |
A
|
Y
|
L
|
F
|
L
|
M
|
F
|
H
|
T
|
G
|
90 |
ECL1 | TM3 | ||||||||
P
|
R
|
T
|
A
|
R
|
L
|
S
|
L
|
E
|
G
|
100 |
W
|
F
|
L
|
R
|
Q
|
G
|
L
|
L
|
D
|
T
|
110 |
S
|
L
|
T
|
A
|
S
|
V
|
A
|
T
|
L
|
L
|
120 |
A
|
I
|
A
|
V
|
E
|
R
|
H
|
R
|
S
|
V
|
130 |
ICL2 | |||||||||
M
|
A
|
V
|
Q
|
L
|
H
|
S
|
R
|
L
|
P
|
140 |
TM4 | |||||||||
R
|
G
|
R
|
V
|
V
|
M
|
L
|
I
|
V
|
G
|
150 |
V
|
W
|
V
|
A
|
A
|
L
|
G
|
L
|
G
|
L
|
160 |
ECL2 | |||||||||
L
|
P
|
A
|
H
|
S
|
W
|
H
|
C
|
L
|
C
|
170 |
A
|
L
|
D
|
R
|
C
|
S
|
R
|
M
|
A
|
P
|
180 |
TM5 | |||||||||
L
|
L
|
S
|
R
|
S
|
Y
|
L
|
A
|
V
|
W
|
190 |
A
|
L
|
S
|
S
|
L
|
L
|
V
|
F
|
L
|
L
|
200 |
M
|
V
|
A
|
V
|
Y
|
T
|
R
|
I
|
F
|
F
|
210 |
Y
|
V
|
R
|
R
|
R
|
V
|
Q
|
R
|
M
|
A
|
220 |
ICL3 | TM6 | ||||||||
E
|
H
|
V
|
S
|
C
|
H
|
P
|
R
|
Y
|
R
|
230 |
E
|
T
|
T
|
L
|
S
|
L
|
V
|
K
|
T
|
V
|
240 |
V
|
I
|
I
|
L
|
G
|
A
|
F
|
V
|
V
|
C
|
250 |
W
|
T
|
P
|
G
|
Q
|
V
|
V
|
L
|
L
|
L
|
260 |
ECL3 | |||||||||
D
|
G
|
L
|
G
|
C
|
E
|
S
|
C
|
N
|
V
|
270 |
TM7 | |||||||||
L
|
A
|
V
|
E
|
K
|
Y
|
F
|
L
|
L
|
L
|
280 |
A
|
E
|
A
|
N
|
S
|
L
|
V
|
N
|
A
|
A
|
290 |
H8 | |||||||||
V
|
Y
|
S
|
C
|
R
|
D
|
A
|
E
|
M
|
R
|
300 |
R
|
T
|
F
|
R
|
R
|
L
|
L
|
C
|
C
|
A
|
310 |
C-term | |||||||||
C
|
L
|
R
|
Q
|
S
|
T
|
R
|
E
|
S
|
V
|
320 |
H
|
Y
|
T
|
S
|
S
|
A
|
Q
|
G
|
G
|
A
|
330 |
S
|
T
|
R
|
I
|
M
|
L
|
P
|
E
|
N
|
G
|
340 |
H
|
P
|
L
|
M
|
D
|
S
|
T
|
L
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
LPA, LYSOPHOSPHATIDIC ACID, 1-O-Oleoyl-D-glycerol 3-phosphoric acid, farnesyl diphosphate, farnesyl monophosphate
STRUCTURE MODELS
STRUCTURES
No structures available