ETB receptor (ednrb_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Endothelin receptors ETB receptor
GENE
EDNRB (ETRB)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Endothelin receptor type B, ET-B, ET-BR, Endothelin receptor non-selective type
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
Q
|
P
|
P
|
P
|
S
|
L
|
C
|
G
|
R
|
10 |
A
|
L
|
V
|
A
|
L
|
V
|
L
|
A
|
C
|
G
|
20 |
L
|
S
|
R
|
I
|
W
|
G
|
E
|
E
|
R
|
G
|
30 |
F
|
P
|
P
|
D
|
R
|
A
|
T
|
P
|
L
|
L
|
40 |
Q
|
T
|
A
|
E
|
I
|
M
|
T
|
P
|
P
|
T
|
50 |
K
|
T
|
L
|
W
|
P
|
K
|
G
|
S
|
N
|
A
|
60 |
S
|
L
|
A
|
R
|
S
|
L
|
A
|
P
|
A
|
E
|
70 |
V
|
P
|
K
|
G
|
D
|
R
|
T
|
A
|
G
|
S
|
80 |
P
|
P
|
R
|
T
|
I
|
S
|
P
|
P
|
P
|
C
|
90 |
TM1 | |||||||||
Q
|
G
|
P
|
I
|
E
|
I
|
K
|
E
|
T
|
F
|
100 |
K
|
Y
|
I
|
N
|
T
|
V
|
V
|
S
|
C
|
L
|
110 |
V
|
F
|
V
|
L
|
G
|
I
|
I
|
G
|
N
|
S
|
120 |
T
|
L
|
L
|
R
|
I
|
I
|
Y
|
K
|
N
|
K
|
130 |
ICL1 | TM2 | ||||||||
C
|
M
|
R
|
N
|
G
|
P
|
N
|
I
|
L
|
I
|
140 |
A
|
S
|
L
|
A
|
L
|
G
|
D
|
L
|
L
|
H
|
150 |
I
|
V
|
I
|
D
|
I
|
P
|
I
|
N
|
V
|
Y
|
160 |
ECL1 | |||||||||
K
|
L
|
L
|
A
|
E
|
D
|
W
|
P
|
F
|
G
|
170 |
TM3 | |||||||||
A
|
E
|
M
|
C
|
K
|
L
|
V
|
P
|
F
|
I
|
180 |
Q
|
K
|
A
|
S
|
V
|
G
|
I
|
T
|
V
|
L
|
190 |
S
|
L
|
C
|
A
|
L
|
S
|
I
|
D
|
R
|
Y
|
200 |
ICL2 | |||||||||
R
|
A
|
V
|
A
|
S
|
W
|
S
|
R
|
I
|
K
|
210 |
TM4 | |||||||||
G
|
I
|
G
|
V
|
P
|
K
|
W
|
T
|
A
|
V
|
220 |
E
|
I
|
V
|
L
|
I
|
W
|
V
|
V
|
S
|
V
|
230 |
V
|
L
|
A
|
V
|
P
|
E
|
A
|
I
|
G
|
F
|
240 |
ECL2 | |||||||||
D
|
I
|
I
|
T
|
M
|
D
|
Y
|
K
|
G
|
S
|
250 |
Y
|
L
|
R
|
I
|
C
|
L
|
L
|
H
|
P
|
V
|
260 |
TM5 | |||||||||
Q
|
K
|
T
|
A
|
F
|
M
|
Q
|
F
|
Y
|
K
|
270 |
T
|
A
|
K
|
D
|
W
|
W
|
L
|
F
|
S
|
F
|
280 |
Y
|
F
|
C
|
L
|
P
|
L
|
A
|
I
|
T
|
A
|
290 |
F
|
F
|
Y
|
T
|
L
|
M
|
T
|
C
|
E
|
M
|
300 |
L
|
R
|
K
|
K
|
S
|
G
|
M
|
Q
|
I
|
A
|
310 |
ICL3 | TM6 | ||||||||
L
|
N
|
D
|
H
|
L
|
K
|
Q
|
R
|
R
|
E
|
320 |
V
|
A
|
K
|
T
|
V
|
F
|
C
|
L
|
V
|
L
|
330 |
V
|
F
|
A
|
L
|
C
|
W
|
L
|
P
|
L
|
H
|
340 |
L
|
S
|
R
|
I
|
L
|
K
|
L
|
T
|
L
|
Y
|
350 |
ECL3 | TM7 | ||||||||
N
|
Q
|
N
|
D
|
P
|
N
|
R
|
C
|
E
|
L
|
360 |
L
|
S
|
F
|
L
|
L
|
V
|
L
|
D
|
Y
|
I
|
370 |
G
|
I
|
N
|
M
|
A
|
S
|
L
|
N
|
S
|
C
|
380 |
I
|
N
|
P
|
I
|
A
|
L
|
Y
|
L
|
V
|
S
|
390 |
H8 | |||||||||
K
|
R
|
F
|
K
|
N
|
C
|
F
|
K
|
S
|
C
|
400 |
C-term | |||||||||
L
|
C
|
C
|
W
|
C
|
Q
|
S
|
F
|
E
|
E
|
410 |
K
|
Q
|
S
|
L
|
E
|
E
|
K
|
Q
|
S
|
C
|
420 |
L
|
K
|
F
|
K
|
A
|
N
|
D
|
H
|
G
|
Y
|
430 |
D
|
N
|
F
|
R
|
S
|
S
|
N
|
K
|
Y
|
S
|
440 |
S
|
S
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
endothelin-2, endothelin-3, endothelin-1