CXCR3 (cxcr3_human)
FAMILY
Class A (Rhodopsin) Protein receptors Chemokine receptors CXCR3
GENE
CXCR3 (GPR9)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
C-X-C chemokine receptor type 3, CXC-R3, CXCR-3, CKR-L2, G protein-coupled receptor 9, Interferon-inducible protein 10 receptor, IP-10 receptor, CD183
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
V
|
L
|
E
|
V
|
S
|
D
|
H
|
Q
|
V
|
10 |
L
|
N
|
D
|
A
|
E
|
V
|
A
|
A
|
L
|
L
|
20 |
E
|
N
|
F
|
S
|
S
|
S
|
Y
|
D
|
Y
|
G
|
30 |
E
|
N
|
E
|
S
|
D
|
S
|
C
|
C
|
T
|
S
|
40 |
TM1 | |||||||||
P
|
P
|
C
|
P
|
Q
|
D
|
F
|
S
|
L
|
N
|
50 |
F
|
D
|
R
|
A
|
F
|
L
|
P
|
A
|
L
|
Y
|
60 |
S
|
L
|
L
|
F
|
L
|
L
|
G
|
L
|
L
|
G
|
70 |
N
|
G
|
A
|
V
|
A
|
A
|
V
|
L
|
L
|
S
|
80 |
ICL1 | TM2 | ||||||||
R
|
R
|
T
|
A
|
L
|
S
|
S
|
T
|
D
|
T
|
90 |
F
|
L
|
L
|
H
|
L
|
A
|
V
|
A
|
D
|
T
|
100 |
L
|
L
|
V
|
L
|
T
|
L
|
P
|
L
|
W
|
A
|
110 |
ECL1 | |||||||||
V
|
D
|
A
|
A
|
V
|
Q
|
W
|
V
|
F
|
G
|
120 |
TM3 | |||||||||
S
|
G
|
L
|
C
|
K
|
V
|
A
|
G
|
A
|
L
|
130 |
F
|
N
|
I
|
N
|
F
|
Y
|
A
|
G
|
A
|
L
|
140 |
L
|
L
|
A
|
C
|
I
|
S
|
F
|
D
|
R
|
Y
|
150 |
ICL2 | |||||||||
L
|
N
|
I
|
V
|
H
|
A
|
T
|
Q
|
L
|
Y
|
160 |
TM4 | |||||||||
R
|
R
|
G
|
P
|
P
|
A
|
R
|
V
|
T
|
L
|
170 |
T
|
C
|
L
|
A
|
V
|
W
|
G
|
L
|
C
|
L
|
180 |
L
|
F
|
A
|
L
|
P
|
D
|
F
|
I
|
F
|
L
|
190 |
ECL2 | |||||||||
S
|
A
|
H
|
H
|
D
|
E
|
R
|
L
|
N
|
A
|
200 |
TM5 | |||||||||
T
|
H
|
C
|
Q
|
Y
|
N
|
F
|
P
|
Q
|
V
|
210 |
G
|
R
|
T
|
A
|
L
|
R
|
V
|
L
|
Q
|
L
|
220 |
V
|
A
|
G
|
F
|
L
|
L
|
P
|
L
|
L
|
V
|
230 |
M
|
A
|
Y
|
C
|
Y
|
A
|
H
|
I
|
L
|
A
|
240 |
ICL3 | |||||||||
V
|
L
|
L
|
V
|
S
|
R
|
G
|
Q
|
R
|
R
|
250 |
TM6 | |||||||||
L
|
R
|
A
|
M
|
R
|
L
|
V
|
V
|
V
|
V
|
260 |
V
|
V
|
A
|
F
|
A
|
L
|
C
|
W
|
T
|
P
|
270 |
Y
|
H
|
L
|
V
|
V
|
L
|
V
|
D
|
I
|
L
|
280 |
ECL3 | |||||||||
M
|
D
|
L
|
G
|
A
|
L
|
A
|
R
|
N
|
C
|
290 |
TM7 | |||||||||
G
|
R
|
E
|
S
|
R
|
V
|
D
|
V
|
A
|
K
|
300 |
S
|
V
|
T
|
S
|
G
|
L
|
G
|
Y
|
M
|
H
|
310 |
C
|
C
|
L
|
N
|
P
|
L
|
L
|
Y
|
A
|
F
|
320 |
H8 | |||||||||
V
|
G
|
V
|
K
|
F
|
R
|
E
|
R
|
M
|
W
|
330 |
M
|
L
|
L
|
L
|
R
|
L
|
G
|
C
|
P
|
N
|
340 |
C-term | |||||||||
Q
|
R
|
G
|
L
|
Q
|
R
|
Q
|
P
|
S
|
S
|
350 |
S
|
R
|
R
|
D
|
S
|
S
|
W
|
S
|
E
|
T
|
360 |
S
|
E
|
A
|
S
|
Y
|
S
|
G
|
L
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
CCL11, CXCL10, CXCL12α, CXCL11, CCL5, CCL19, CCL20, CCL13, CXCL9, CCL7