GPCRdb

NPFF1 receptor - G_i1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9VIF

RESOLUTION

3.2 Å

REFERENCE

10.1093/PROCEL/PWAF090

PUBLICATION DATE

Dec. 3, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

43 interactions (Click to see)

LIGANDS

neuropeptide FF (Human) - Agonist pubchem gtoplig chembl_ligand uniprot uniprot uniprot

PHYSIOLOGICAL LIGANDS

QRFP43 (43RFa) (Human), neuropeptide AF (Rat), neuropeptide AF (Human), neuropeptide SF (Mouse), RFRP-3 (Human), neuropeptide SF (Human), PrRP-31 (Human), neuropeptide AF (Mouse), neuropeptide FF (Human), RFRP-1 (Human), neuropeptide SF (Rat)

GPCR - G protein interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)