EP2 receptor (pe2r2_human)
FAMILY
Class A (Rhodopsin) Lipid receptors Prostanoid receptors EP2 receptor
GENE
PTGER2
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Prostaglandin E2 receptor EP2 subtype, PGE receptor EP2 subtype, PGE2 receptor EP2 subtype, Prostanoid EP2 receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
G
|
N
|
A
|
S
|
N
|
D
|
S
|
Q
|
S
|
10 |
E
|
D
|
C
|
E
|
T
|
R
|
Q
|
W
|
L
|
P
|
20 |
TM1 | |||||||||
P
|
G
|
E
|
S
|
P
|
A
|
I
|
S
|
S
|
V
|
30 |
M
|
F
|
S
|
A
|
G
|
V
|
L
|
G
|
N
|
L
|
40 |
I
|
A
|
L
|
A
|
L
|
L
|
A
|
R
|
R
|
W
|
50 |
ICL1 | |||||||||
R
|
G
|
D
|
V
|
G
|
C
|
S
|
A
|
G
|
R
|
60 |
TM2 | |||||||||
R
|
S
|
S
|
L
|
S
|
L
|
F
|
H
|
V
|
L
|
70 |
V
|
T
|
E
|
L
|
V
|
F
|
T
|
D
|
L
|
L
|
80 |
G
|
T
|
C
|
L
|
I
|
S
|
P
|
V
|
V
|
L
|
90 |
ECL1 | |||||||||
A
|
S
|
Y
|
A
|
R
|
N
|
Q
|
T
|
L
|
V
|
100 |
TM3 | |||||||||
A
|
L
|
A
|
P
|
E
|
S
|
R
|
A
|
C
|
T
|
110 |
Y
|
F
|
A
|
F
|
A
|
M
|
T
|
F
|
F
|
S
|
120 |
L
|
A
|
T
|
M
|
L
|
M
|
L
|
F
|
A
|
M
|
130 |
A
|
L
|
E
|
R
|
Y
|
L
|
S
|
I
|
G
|
H
|
140 |
ICL2 | |||||||||
P
|
Y
|
F
|
Y
|
Q
|
R
|
R
|
V
|
S
|
R
|
150 |
TM4 | |||||||||
S
|
G
|
G
|
L
|
A
|
V
|
L
|
P
|
V
|
I
|
160 |
Y
|
A
|
V
|
S
|
L
|
L
|
F
|
C
|
S
|
L
|
170 |
ECL2 | |||||||||
P
|
L
|
L
|
D
|
Y
|
G
|
Q
|
Y
|
V
|
Q
|
180 |
Y
|
C
|
P
|
G
|
T
|
W
|
C
|
F
|
I
|
R
|
190 |
TM5 | |||||||||
H
|
G
|
R
|
T
|
A
|
Y
|
L
|
Q
|
L
|
Y
|
200 |
A
|
T
|
L
|
L
|
L
|
L
|
L
|
I
|
V
|
S
|
210 |
V
|
L
|
A
|
C
|
N
|
F
|
S
|
V
|
I
|
L
|
220 |
N
|
L
|
I
|
R
|
M
|
H
|
R
|
R
|
S
|
R
|
230 |
ICL3 | |||||||||
R
|
S
|
R
|
C
|
G
|
P
|
S
|
L
|
G
|
S
|
240 |
G
|
R
|
G
|
G
|
P
|
G
|
A
|
R
|
R
|
R
|
250 |
TM6 | |||||||||
G
|
E
|
R
|
V
|
S
|
M
|
A
|
E
|
E
|
T
|
260 |
D
|
H
|
L
|
I
|
L
|
L
|
A
|
I
|
M
|
T
|
270 |
I
|
T
|
F
|
A
|
V
|
C
|
S
|
L
|
P
|
F
|
280 |
ECL3 | |||||||||
T
|
I
|
F
|
A
|
Y
|
M
|
N
|
E
|
T
|
S
|
290 |
TM7 | |||||||||
S
|
R
|
K
|
E
|
K
|
W
|
D
|
L
|
Q
|
A
|
300 |
L
|
R
|
F
|
L
|
S
|
I
|
N
|
S
|
I
|
I
|
310 |
H8 | |||||||||
D
|
P
|
W
|
V
|
F
|
A
|
I
|
L
|
R
|
P
|
320 |
P
|
V
|
L
|
R
|
L
|
M
|
R
|
S
|
V
|
L
|
330 |
C-term | |||||||||
C
|
C
|
R
|
I
|
S
|
L
|
R
|
T
|
Q
|
D
|
340 |
A
|
T
|
Q
|
T
|
S
|
C
|
S
|
T
|
Q
|
S
|
350 |
D
|
A
|
S
|
K
|
Q
|
A
|
D
|
L
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
PGF2α, PGI2, PGD2, thromboxane A2, PGE1, PGE2
STRUCTURE MODELS
STRUCTURES
Found 3 structure(s) - view all details on the Structures page